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| Product | Description | |
|---|---|---|
| ML213 | ML213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) with > 80-fold selectivity against other related K+ channels, and enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Synonyms: N-(2, 4, 6-trimethylphenyl)bicyclo[2. 2. 1]heptane-3-carboxamide; N-mesitylbicyclo[2.2.1]heptane-2-carboxamide; ML213; ML 213; ML-213; CID-3111211; CID 3111211; CID3111211; AK174864; N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide. CAS No. 489402-47-3. Molecular formula: C17H23NO. Mole weight: 257.37. |  |
| ML 213 | ML 213. Group: Biochemicals. Grades: Purified. CAS No. 489402-47-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| ML216 | Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells. Synonyms: ML 216; ML-216; CID-49852229; CID49852229; CID 49852229. Grades: >98%. CAS No. 1430213-30-1. Molecular formula: C15H9F4N5OS. Mole weight: 383.32. | |
| ML 218 hydrochloride | ML 218 hydrochloride is a T-type calcium channel inhibitor with IC50 values of 270 nM for Cav3.3 and 310 nM for Cav3.2. It has potential applications for the treatment of pain. Synonyms: ML218; ML 218; ML-218. 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1346233-68-8. Molecular formula: C19H26Cl2N2O.HCl. Mole weight: 405.79. | |
| ML 218 hydrochloride | ML 218 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1346233-68-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 221 | ML 221 is an apelin receptor antagonist with IC50 values of 0.70μM in a cAMP assay and 1.75 μM in β-arrestin assay. It has the potential to be used to treat or mediate the homeostasis of the cardiovascular system. Synonyms: ML221; ML 221; ML-221. 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one. Grades: ≥99% by HPLC. CAS No. 877636-42-5. Molecular formula: C17H11N3O6S. Mole weight: 385.35. | |
| ML 221 | ML 221. Group: Biochemicals. Grades: Purified. CAS No. 877636-42-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML224 | ML224, a TSHR inverse agonist, has been found to reduce serum free T4 and thyroperoxidase in mice in in vivo study. IC50: 2.3 uM. Uses: Ml224 is a tshr inverse agonist that has been found to reduce serum free t4 and thyroperoxidase in mice in in vivo study. Synonyms: ML224; ML-224; ML 224; NCGC00242364; NCGC-00242364; NCGC 00242364; ANTAG3; ANTAG-3; ANTAG 3; MLS003370609; SCHEMBL14151304; CS-3824; NCGC00242364-01. Grades: 98%. CAS No. 1338824-21-7. Molecular formula: C31H31N3O5. Mole weight: 525.59. | |
| ML-226 | ML-226 is an inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with 100-fold greater selectivity for ABHD11 over approximately 20 other serine hydrolases. It can be used as an anti-probe for ML-211. Synonyms: ML 226; ML226; (2-Ethylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanone. Grades: ≥98%. CAS No. 2055172-43-3. Molecular formula: C23H26N4O2. Mole weight: 390.48. | |
| ML228 | HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM. Synonyms: ML-228; ML 228; ML228; CID-46742353; CID 46742353; CID46742353. Grades: >98%. CAS No. 1357171-62-0. Molecular formula: C27H21N5. Mole weight: 415.49. | |
| ML 228 | ML 228. Group: Biochemicals. Grades: Purified. CAS No. 1357171-62-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-23 | ML-23 is a melatonin analogue. It is a potential clinical candidate for the treatment of Parkinson's disease. It produced a significant remission from MPTP-induced Parkinsonism and this effect did not abate when the treatment was withdrawn on all parameters. Uses: Ml-23 is a potential clinical candidate for the treatment of parkinson's disease. Synonyms: ML-23; ML23; ML 23; N-(3,5-Dinitrophenyl)-5-methoxy-1H-indole-3-ethanamine;N-(2,4-Dinitrophenyl)-5-methoxytryptamine;1H-Indole-3-ethanamine,N-(2,4-dinitrophenyl)-5-methoxy-;ML23;N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-3,5-dinitroaniline. Grades: >98%. CAS No. 108929-03-9. Molecular formula: C17H16N4O5. Mole weight: 356.34. | |
| ML230 | ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID44640177; SID 88095709. CAS No. 1776055-05-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111678. |  |
| ML 233 | ML-233 is a novel apelin receptor agonist with EC50 value of 3.7 μM. Synonyms: ML 233; ML233; ML-233; (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one. Grades: ≥98% by HPLC. CAS No. 2080311-92-6. Molecular formula: C19H21NO4S. Mole weight: 359.44. | |
| ML 236A | It has the activity of inhibiting HMG-CoA reductase, and it is produced by the strain of Penicillum citrinum SANK. Synonyms: Compactin diol lactone; ML-236A; 6-(2-(1,2,6,7,8,8a-Hexahydro-8-hydroxy-2-methyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one; desmethylmonacolin J; Antibiotic ML 236A. CAS No. 58889-19-3. Molecular formula: C18H26O4. Mole weight: 306.40. | |
| ML240 | ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 value of 100 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346527-98-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19795. | |
| ML240 | ML240, a quinazoline derivative, has been found to be a p97 ATPase inhibitor and probably be effective against colon cancer and show antiproliferative activity in NCI-60 cancer cell lines. IC50: 100 nM. Uses: Ml240 has been found to be a p97 atpase inhibitor and probably be effective against colon cancer and show antiproliferative activity in nci-60 cancer cell lines. Synonyms: ML240; ML-240; ML 240. MLS003568129; KUC107871N; SMR002239184; 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine; 2nd batch of KSC-16-270. Grades: 95%. CAS No. 1346527-98-7. Molecular formula: C23H20N6O. Mole weight: 396.44. | |
| ML 240 | ML 240. Group: Biochemicals. Grades: Purified. CAS No. 1346527-98-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML241 | ML241 is a selective p97 ATPase inhibitor and IC50 value is 100 nM. It can inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the treatment of cancer. Uses: Anticancer. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine; ML241; ML-241; ML 241. Grades: 98%. CAS No. 1346528-06-0. Molecular formula: C23H24N4O. Mole weight: 372.46. | |
| ML241 HCl | ML241 is identified as a potent and selective inhibitors of p97 ATPase (IC(50)= 100 nM). ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 could impair the endoplasmic-reticulum-associated degradation (ERAD) pathway. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine hydrochloride; ML241; ML-241; ML 241; ML241 HCl; ML241 hydrochloride. CAS No. 2070015-13-1. Molecular formula: C23H25ClN4O. Mole weight: 408.93. | |
| ML243 (Cancer Stem Cell Inhibitor, ML243, (E) -N- (4, 5-Dihydrothiazol-2-yl) -3- (4-ethylphenyl) acrylamide, (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)prop-2-enamide) | A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2uM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64uM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5uM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10uM), but does not affect 68 other targets studied. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| ML252 | ML252 is a selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM) used in vivo to study KCNQ2 pharmocology. Synonyms: AOB1824; ML252; AOB 1824; ML 252; AOB-1824; ML-252; (2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide hydrochloride. Grades: 99%. CAS No. 1392494-64-2. Molecular formula: C20H24N2O.HCl. Mole weight: 344.88. | |
| ML254 | ML254 is a potent mGlu 5 potentiator, with EC 50 and pEC 50 of 9.3 nM and 8.03 nM for rat mGlu 5 , respectively. ML254 can be used for researching schizophrenia [1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1428630-86-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16654. | |
| ML264 | ML264 is an antitumor agent that potently and selectively inhibits Krüppel-like factor five ( KLF5 ) expression. Uses: Scientific research. Group: Signaling pathways. CAS No. 1550008-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19994. | |
| ML264 | ML264 is a Krüppel-like factor 5 (KLF5) inhibitor with the potential to inhibits growth of colorectal cancer. It reduces EGR1 and KLF5 levels so that ML264 inhibits the MAPK pathway. in a cell-based assay for proliferation of DLD-1 cells: IC50 = 29 nM, in. Synonyms: (E)-3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-methylamino]-2-oxoethyl]prop-2-enamideML264; ML264; ML 264; MLS003874889SCHEMBL15605936SCHE MBL17045845CS-5628; CS 5628; CS5628HY-19994; HY 19994; HY19994SMR002531696SR-03000002171SR-03000002171-1(E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-. CAS No. 1550008-55-3. Molecular formula: C17H21ClN2O4S. Mole weight: 384.88. | |
| ML277 | ML277, a sulfonylpiperidine compound, has been found to be a KCNQ1 K+ channel activator and could be used in the study of the activity of K+ channel in human cardiomyocytes. IC50: 270 nM (EC50). Uses: Ml277 has been found to be a kcnq1 k+ channel activator and could be used in the study of the activity of k+ channel in human cardiomyocytes. Synonyms: ML277; ML 277; ML-277; CHEMBL2070953; (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide; ML 277; 1401242-74-7; MLS003875054. Grades: 98%. CAS No. 1401242-74-7. Molecular formula: C23H25N3O4S2. Mole weight: 471.59. | |
| ML 277 | ML 277. Group: Biochemicals. Grades: Purified. CAS No. 1401242-74-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML281 | ML281, a quinoxalin derivative, has been found to be a STK33 inhibitor and could have probable effect against KRAS-dependent cancers. IC50: 14 nM. Uses: Ml281 has been found to be a stk33 inhibitor and could have probable effect against kras-dependent cancers. Synonyms: ML-281; ML-281; ML281. CHEMBL2204239; Bg-stk33-59; MLS003876599; BRD8942; BRD-8942. Grades: 98%. CAS No. 1404437-62-2. Molecular formula: C22H19N3O2S. Mole weight: 389.47. | |
| ML 281 | ML 281. Group: Biochemicals. Grades: Purified. CAS No. 1404437-62-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 289 | ML 289. Group: Biochemicals. Grades: Purified. CAS No. 1382481-79-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 289 | ML-289 is a negative allosteric modulator of mGlu3 with IC50 value of 0.66 μM. It displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1. Synonyms: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289; [ (3R) -3- (Hydroxymethyl) -1-pipridinyl][4-[2- (4-methoxyphenyl) ethynyl]phenyl]methanone. Grades: ≥98% by HPLC. CAS No. 1382481-79-9. Molecular formula: C22H23NO3. Mole weight: 349.42. | |
| ML-290 | ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1). It increases cAMP accumulation and VEGF expression in cells that endogenously express human RXFP1. ML290 exhibits antifibrotic effects in liver fibrosis. Synonyms: ML 290; ML290; RXFP1 Agonist 8??; 2-[ (2-propan-2-yloxybenzoyl) amino]-N-[3- (trifluoromethylsulfonyl) phenyl]benzamide. Grades: ≥95%. CAS No. 1482500-76-4. Molecular formula: C24H21F3N2O5S. Mole weight: 506.5. | |
| ML-291 | ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm. It induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP, but not in wild-type or CHOP knockout cells. Synonyms: ML 291; ML291; N-(4-((4-chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide. Grades: ≥98%. CAS No. 1523437-16-2. Molecular formula: C16H16ClN3O6S. Mole weight: 413.8. | |
| ML 297 | ML 297. Group: Biochemicals. Grades: Highly Purified. CAS No. 1443246-62-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 297 | ML 297 is a Kir3.1/3.2 (GIRK1/2) channel activator with IC50 values of 160, 887 and 914 nM for GIRK1/2, GIRK1/4 and GIRK1/3. Synonyms: ML297; ML 297; ML-297; N-(3,4-Difluorophenyl)-N'-(3-methyl-1-phenyl-1H-pyrazol-5-yl)urea. Grades: ≥99% by HPLC. CAS No. 1443246-62-5. Molecular formula: C17H14F2N4O. Mole weight: 328.32. | |
| ML 297 | ML 297 (VU 0456810) is a potent and selective GIRK 1/2 activator, with an EC 50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VU 0456810; CID 56642816. CAS No. 1443246-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110192. | |
| ML-298 | ML-298 is a potent inhibitor of phospholipase D2 (PLD2) displaying selectivity for PLD2 over PLD1 with IC50 values of 355 and 20000 nM, respectively. Synonyms: ML 298; ML298; 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl]benzamide. Grades: ≥98%. CAS No. 1426916-02-0. Molecular formula: C22H23F3N4O2. Mole weight: 432.4. | |
| ML 298 hydrochloride | ML 298 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 298 hydrochloride | ML 298 hydrochloride is a phospholipase D2 inhibitor with IC50 values are 355 for PLD2 and >20,000 nM for PLD1. It can decrease invasive migration in U87-MG glioblastoma cells. Synonyms: ML 298 hydrochloride; ML298 hydrochloride; ML-298 hydrochloride; 3,4-Difluoro-N-[2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]benzamide hydrochloride. Grades: ≥98% by HPLC. Molecular formula: C22H23F3N4O2.HCl. Mole weight: 468.9. | |
| ML-299 | ML-299 is an allosteric, dual inhibitor of PLD1/PLD2 with IC50 values of 6 and 20 nM, respectively. It can be used as a probe for detecting PLD1 and PLD2 function in vitro and in vivo. Synonyms: ML 299; ML299; CID 56593087; 4-Bromo-N-[(2S)-1-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]propan-2-yl]benzamide. Grades: ≥95%. CAS No. 1426916-00-8. Molecular formula: C23H26BrFN4O2. Mole weight: 489.4. | |
| ML309 | ML309 is a potent inhibitor of R132H mutant IDH1 capable of reducing 2-hydroxyglutarate production in U87 MG glioblastoma cells. ML309 is capable of potent and selective inhibition of mutant IDH1 and effectively lowers cell-based production of 2-HG in a U87MG mutant glioblastoma cell line. Synonyms: ML-309; ML 309. Grades: 98%. CAS No. 1355446-05-7. Molecular formula: C29H29FN4O2. Mole weight: 484.56. | |
| ML-309 hydrochloride | ML-309 is a potent and selective inhibitor of mutant isocitrate dehydrogenase 1 (IDH1). It reduces 2-hydroxyglutarate production in U87 MG glioblastoma cells. Synonyms: ML 309 hydrochloride; ML309 hydrochloride; ML-309 HCl; 2-(N-[2-(benzimidazol-1-yl)acetyl]-3-fluoroanilino)-N-cyclopentyl-2-(2-methylphenyl)acetamide hydrochloride. Grades: ≥98%. CAS No. 1355327-02-4. Molecular formula: C29H29FN4O2·HCl. Mole weight: 521. | |
| ML311 | ML311, also known as EU-5346, is a potent and selective inhibitor of the Protein-Protein Interaction of Mcl-1 and Bim. EU-5346 inhibits proliferation of Her2-positive BC cells in a dose-dependent manner. ML311 is a useful tool for studying lymphoid tumorigenesis and to demonstrate the potential for using this strategy in therapies intended to bypass apoptosis resistance pathways that are activated in drug-resistant tumors. Synonyms: 7-[ (4-Ethylpiperazin-1-yl) -[4- (trifluoromethyl) phenyl]methyl]quinolin-8-ol; ML311; ML-311; ML 311; EU-5346; EU 5346; EU5346. CAS No. 315698-17-0. Molecular formula: C23H24F3N3O. Mole weight: 415.46. | |
| ML-314 | Medicinal chemistry optimization of MLS-0233108 led to ML314, the most potent molecule in this second series that exhibited full agonist behavior (100 %) on NTR1 (EC50 = 1.9 μM). ML314 showed good selectivity against NTR2 and GPR35, but did not stimulate Ca2+ mobilization. ML314 is potentially a biased agonist operating via the β-arrestin pathway rather than the traditional Gq coupled pathway. Signaling mediated by β-arrestin has distinct biochemical and functional consequences that may lead to physiological advantages as described below. This probe report describes the discovery and properties of ML301 and summarizes the HTS and follow-up campaign, which identified ML314. Synonyms: ML 314; ML-314; ML314. Grades: 0.98. CAS No. 1448895-09-7. Molecular formula: C24H28N4O3. Mole weight: 420.513. | |
| ML 315 hydrochloride | ML 315 is a selective dual inhibitor of CDK and DYRK with IC 50 s of 68 nM and 282 nM, respectively. ML 315 is used in cancer and neurological disease research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2172559-91-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117608A. | |
| ML 315 hydrochloride | ML 315 hydrochloride is a cdc2-like kinase and DYRK kinase inhibitor with IC50 values of 68, 68 and 231 nM for Clk1, Clk4 and Clk2 and 282 and 1156 nM for Dyrk1A and Dyrk1B. Synonyms: ML 315 hydrochloride; ML315 hydrochloride; ML-315 hydrochloride; 5-(1,3-Benzodioxol-5-yl)-N-[(3,5-dichlorophenyl)methyl]-4-pyrimidinamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 1440251-53-5. Molecular formula: C18H13Cl2N3O2.HCl. Mole weight: 410.68. | |
| ML318 | ML318 is a novel inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1610516-67-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H8F4N2, Molecular Weight: 280.22. US Biological Life Sciences. | Worldwide |
| ML-323 | ML323 is a reversible and potent USP1-UAF1 inhibitor with IC50 vallue of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. Synonyms: ML-323; ML 323; ML323. CAS No. 1572414-83-5. Molecular formula: C23H24N6. Mole weight: 384.487. | |
| ML324 | ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. Synonyms: ML-324; ML 324; ML324; CID-44143209; CID 44143209; CID44143209. Grades: >98%. CAS No. 1222800-79-4. Molecular formula: C21H23N3O2. Mole weight: 349.43. | |
| ML 324 dihydrochloride | ML 324 dihydrochloride is an inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase. It potently suppresses herpes simplex virus (HSV) IE gene expression and viral reactivation from latency. Synonyms: ML 324 dihydrochloride; ML324 dihydrochloride; ML-324 dihydrochloride; N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide dihydrochloride. Grades: 99%. Molecular formula: C21H23N3O2.2HCl. Mole weight: 422.35. | |
| ML329 | ML329 is a small molecule MITF inhibitor that inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 inhibits TRPM-1 promoter activity (IC50 = 1.2 μM). Synonyms: 4-[(1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide; ML329; ML 329; ML-329. CAS No. 19992-50-8. Molecular formula: C16H12N2O4S. Mole weight: 328.34. | |
| ML 334 | ML 334 is an inhibitor of Keap1-Nrf2 interaction. It can affect the cytoprotective responses to oxidative and electrophilic stress. Synonyms: ML 334; ML334; ML-334; (1S, 2R) -2- [ [ (1S) -1- [ (1, 3-Dihydro-1, 3-dioxo-2H-isoindol-2-yl) methyl] -3, 4-dihydro-2 (1H) -isoquinolinyl] carbonyl] cyclohexanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1432500-66-7. Molecular formula: C26H26N2O5. Mole weight: 446.5. | |
| ML-335 | ML-335 is a potent and selective TREK-1/2 activator with EC50 values of 14.3 μM and 5.2 μM, respectively. Synonyms: ML 335; ML335; N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide. Grades: ≥98% by HPLC. CAS No. 825658-06-8. Molecular formula: C15H14Cl2N2O3S. Mole weight: 373.25. | |
| ML-336 | ML-336 is a quinazolinone-based inhibitor of Venezuelan Equine Encephalitis Virus (VEEV). It inhibits VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and Trinidad donkey). Synonyms: ML 336; ML336; (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-n-phenylbenzamide. Grades: ≥95%. CAS No. 1613465-33-0. Molecular formula: C19H21N5O3. Mole weight: 367.4. | |
| ML337 | ML337 is a Selective negative allosteric modulator of mGlu3 with IC50 value of 593 nM. It shows no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. ML337 is a best-in-class probe for studying non-competitive antagonism of mGlu3. Uses: In vitro and in vivo probe for studying non-competitive antagonism of mglu3. Synonyms: CHEMBL2385886; ML337; ML 337; ML-337; MLS004580699; GTPL8765;(R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone. Grades: 98%. CAS No. 1443118-44-2. Molecular formula: C21H20FNO3. Mole weight: 353.39. | |
| ML 337 | ML 337. Group: Biochemicals. Grades: Purified. CAS No. 1443118-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML339 | ML339 is a potent and selective CXCR6 antagonist (IC50 = 140 nM) that is selective (IC50 >79 μM) against CXCR5, CXCR4, CCR6 and Apelin receptor (APJ). It has the potential to advance the field of prostate cancer research. Synonyms: N-[(1R,5S)-9-{2-[(2-Chlorophenyl)amino]-2-oxoethyl}-9-azabicyclo[3.3.1]non-3-yl]-3,4,5-trimethoxybenzamide; 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)-. Grades: ≥95%. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.00. | |
| ML-339 | ML-339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM). Group: Antagonists. Alternative Names: ML-339; ML 339; ML339. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.01. Appearance: Solid powder. Purity: >98%. IUPACName: N-((1R,3s,5S)-9-(2-((2-chlorophenyl)amino)-2-oxoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide. Canonical SMILES: O=C (N[C@@H]1C[C@H] (N2CC (NC3=CC=CC=C3Cl)=O)CCC[C@H]2C1)C4=CC (OC)=C (OC)C (OC)=C4. Catalog: ACM2579689839. |  |
| ML3403 | ML 3403 is a potent and selective p38 mitogen-activated protein kinase (MAPK) inhibitor. MAPK is a key mediator in cytokine-induced signaling events and plays an integral role in disease states including oncogenesis, autoimmune diseases, and inflammatory processes. Therefore, MAPK inhibitors such as ML 3403 provides an attractive strategy for therapeutic intervention. Synonyms: ML 3403; ML-3403; p38 MAP Kinase Inhibitor III; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine. Grades: 98%. CAS No. 549505-65-9. Molecular formula: C23H21FN4S. Mole weight: 404.51. | |
| ML 3403 | ML 3403. Group: Biochemicals. Grades: Purified. CAS No. 549505-65-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-345 | ML-345 is a small-molecule inhibitor of insulin-degrading enzyme (IDE) that selectively targets Cys819 in IDE. ML-345 is potentially utilized as a pharmacophore for drug development in diabetes and Alzheimer's disease research. Synonyms: ML 345; ML345; 5-Fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one. Grades: ≥95%. CAS No. 1632125-79-1. Molecular formula: C21H22FN3O5S2. Mole weight: 479.5. | |
| ML346 | ML346, a barbituric acid skeleton compound, is a novel activator of Hsp70 which could induce HSF-1-dependent chaperone expression and repair protein folding in both cellular and animal models. It has no obvious cytotoxicity and shows some extent of specif. Uses: Ml346 is a novel activator of hsp70 which could induce hsf-1-dependent chaperone expression and repair protein folding in both cellular and animal models. Synonyms: ML346; ML-346; ML 346; ZINC00244844; AC1LG9A8; Ambcb5772104; MLS004711999; SCHEMBL13317556. Grades: 95%. CAS No. 100872-83-1. Molecular formula: C14H12N2O4. Mole weight: 272.26. | |
| ML347 | ML347 is a selective BMP receptor inhibitor with IC50 value of 32 nM for ALK2, >300-fold selectivity over ALK3. It also inhibits ALK1 activity with IC50 value of 46 nM. Synonyms: ML-347; 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1062368-49-3. Molecular formula: C22H16N4O. Mole weight: 352.39. | |
| ML 347 | ML 347. Group: Biochemicals. Grades: Purified. CAS No. 1062368-49-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML348 | ML348, also known as CID 3238952 or SID 160654487, is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000). Synonyms: N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide; ML348; ML-348; ML 348; CID 3238952; SID 160654487. CAS No. 899713-86-1. Molecular formula: C18H17ClF3N3O3. Mole weight: 415.79. | |
| ML 348 | ML 348. Group: Biochemicals. Grades: Purified. CAS No. 899713-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 349 | ML 349 is a lysophospholipase 2 inhibitor with IC50 value of 144 nM. Synonyms: ML349; ML-349; ML 349. (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone. Grades: ≥98% by HPLC. CAS No. 890819-86-0. Molecular formula: C23H22N2O4S2. Mole weight: 454.56. | |
| ML 349 | ML 349. Group: Biochemicals. Grades: Purified. CAS No. 890819-86-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML351 | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC 50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 [1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310. | |
| ML 351 | ML 351 is a potent and selective inhibitor of 12/15-lipoxygenase (IC50 value 200 nM against human 12/15-LOX), which catalyzes the oxidation of polyunsaturated fatty acids to produce unsaturated fatty acid hydroperoxides. Studies indicate that ML351 is protective against oxidative glutamate toxicity in mouse neuronal HT22 cells, and reduces infarct size following permanent focal ischemia in a mouse model of ischemic stroke. Synonyms: ML 351; ML-351; ML351; CID 664510; CID664510; CID-664510; 5-(methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile. Grades: 98%. CAS No. 847163-28-4. Molecular formula: C15H11N3O. Mole weight: 249.27. | |
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