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| Product | Description | |
|---|---|---|
| ML 133 hydrochloride | ML 133 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1222781-70-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| ML133 hydrochloride | ML133 hydrochloride is a selective K ir 2 family channels inhibitor, with an IC 50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100230A. |  |
| ML141 | ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM. Synonyms: Ro111163; Ro-111163; Ro 111163; ML-141; ML 141; ML141; CID2950007; CID-2950007; CID 2950007. Grades: >98%. CAS No. 71203-35-5. Molecular formula: C22H21N3O3S. Mole weight: 407.49. |  |
| ML 141 | ML 141. Group: Biochemicals. Grades: Purified. CAS No. 71203-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145 is a GPR35 orphan receptor antagonist with IC50 value of 20.1 nM. It can be used in the treatment of disorders affecting the stomach as well as the immune system. Synonyms: ML 145; ML145; ML-145; 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1164500-72-4. Molecular formula: C24H22N2O5S2. Mole weight: 482.57. | |
| ML-148 | ML-148 is a potent and selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Synonyms: ML 148; ML148; [1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone. Grades: ≥98%. CAS No. 451496-96-1. Molecular formula: C20H21N3O. Mole weight: 319.4. | |
| ML 154 | ML 154 is a neuropeptide S receptor antagonist. It has the potential to be used in the treatment of sleep, anxiety and addiction disorders. Synonyms: NCGC 84; NCGC84; NCGC-84; ML 154; ML154; ML-154; NCGC00185684. 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide. Grades: ≥99% by HPLC. CAS No. 1345964-89-7. Molecular formula: C29H26N2PS.Br. Mole weight: 545.47. | |
| ML 154 | ML 154. Group: Biochemicals. Grades: Purified. CAS No. 1345964-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 161 | Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 muM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. Synonyms: ML-161; ML161; Parmodulin 2; 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide. CAS No. 423735-93-7. Molecular formula: C17H17BrN2O2. Mole weight: 361.24. | |
| ML 161 | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML162 | ML162 Inhibitor. Uses: Scientific use. Product Category: T8970. CAS No. 1035072-16-2. |  |
| ML-162 | ML-162 is a GPX4 inhibitor that selectively kills cells induced to express mutant RAS. GPX4 is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death). Synonyms: ML 162; ML162; 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide. Grades: ≥95%. CAS No. 1035072-16-2. Molecular formula: C23H22Cl2N2O3S. Mole weight: 477.4. | |
| ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. Synonyms: CID44968231; NCGC00188654; [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol; 2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-. Grades: >98%. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. | |
| ML167 | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (Clk 's) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk 's) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. Purity: >98%. IUPACName: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol. Canonical SMILES: OCC1=CC=C(C2=CC3=C(NCC4=CC=C(C)O4)N=CN=C3C=C2)O1. Product ID: ACM1285702206. Alfa Chemistry ISO 9001:2015 Certified. Categories: M167 VADS. |  |
| ML 171 | ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| ML-178 | ML-178 is a selective S1P4 activator with EC50 value of 46.3 nM without effect against S1P1, S1P2, S1P3, and S1P5. Synonyms: ML 178; ML178; CID 44620892; CYM 50179; SID 87544119; 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine. Grades: ≥95%. CAS No. 1355026-47-9. Molecular formula: C13H9Br2Cl2NO2. Mole weight: 441.9. | |
| ML 179 | ML 179 is a liver receptor homolog 1 inverse agonist with IC50 value of 320 nM. Synonyms: ML 179; ML179; ML-179; 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione. Grades: ≥99% by HPLC. CAS No. 1883548-87-5. Molecular formula: C21H25F3N4O2. Mole weight: 422.44. | |
| ML 179 | ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 18 | ML 18 is a bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM) and binds GRPR (IC50 = 16 μM) with potential in combating lung cancer cells. Synonyms: ML-18; ML 18; ML18. 1H-Indole-3-propanamide, N-[[1- (4-methoxyphenyl) ?cyclohexyl]?methyl]?-α -[[[ (4-nitrophenyl) ?amino]?carbonyl]?amino]?-, (αS)?-; (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl]-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide. CAS No. 1422269-30-4. Molecular formula: C32H35N5O5. Mole weight: 569.65. | |
| ML-180 | ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1) that inhibits cell proliferation. Synonyms: ML 180; ML180; CID-3238389; SR1848; 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione. Grades: ≥98%. CAS No. 863588-32-3. Molecular formula: C20H25ClN4O2. Mole weight: 388.9. | |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2 ) inverse agonist with an IC 50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1 ; IC 50 >10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML188 | ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide. Product Category: Inhibitors. Appearance: White to off-white solid. CAS No. 1417700-13-0. Molecular formula: C26H31N3O3. Mole weight: 433.55. Purity: 0.98. IUPACName: N-[(1R)-2-(tert-butylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide. Canonical SMILES: CC(C)(C)C1=CC=C(C=C1)N([C@H](C2=CN=CC=C2)C(=O)NC(C)(C)C)C(=O)C3=CC=CO3. Product ID: ACM1417700130. Alfa Chemistry ISO 9001:2015 Certified. Categories: M1885 Remington-Lee. | |
| ML 190 | ML 190 is a κ opioid receptor antagonist with IC50 value of 120 nM. Synonyms: ML 190; ML190; ML-190; N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide. Grades: ≥98% by HPLC. CAS No. 1355244-02-8. Molecular formula: C27H32N6O3. Mole weight: 488.58. | |
| ML 190 | ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-191 | ML-191 is a GPR55 antagonist inhibiting LPI-induced phosphorylation of ERK1/2 and blocking receptor-dependent translocation of PKCβII. Synonyms: ML 191; ML191; CCG-152883; CID-23612552; 3-[1-[[1-(4-Methylphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one. Grades: ≥98%. CAS No. 931695-79-3. Molecular formula: C24H25N3O3. Mole weight: 403.5. | |
| ML192 | ML192 is a selective ligands for GPR55 with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2. Uses: Potent and selective antagonist for gpr55. Synonyms: ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. furan-2-yl(4-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl)methanone. Grades: ≥98%. CAS No. 460331-61-7. Molecular formula: C20H22N4O2S. Mole weight: 382.48. | |
| ML 193 | ML 193 is a GPR55 antagonist with IC50 value of 221 nM. Synonyms: ML-193; ML 193; ML193; CID 1261822; CID-1261822; CID1261822; N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 713121-80-3. Molecular formula: C28H25N5O4S. Mole weight: 527.59. | |
| ML 202 | ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML204 | ML204 is a novel and potential TRPC4 Channel inhibitor. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. Synonyms: 4-Methyl-2-piperidin-1-ylquinoline; ML204; ML 204; ML-204. Grades: > 98%. CAS No. 5465-86-1. Molecular formula: C15H18N2. Mole weight: 226.323. | |
| ML 204 | ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML204 hydrochloride | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A. | |
| ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline ) | Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Group: Biochemicals. Grades: Highly Purified. CAS No. 5465-86-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 210 | ML 210 is a selective RAS inhibitor that kills cells induced to express mutant RAS. ML210 exhibits nanomolar potency against two HRASG12V expressing cell lines and 4-fold selectivity against two control cell lines not expressing HRASG12V. Synonyms: CID 49766530; CID-49766530; CID49766530; ML-210; ML 210; ML210. [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone. Grades: 99%. CAS No. 1360705-96-9. Molecular formula: C22H20Cl2N4O4. Mole weight: 475.32. | |
| ML-211 | ML-211 is a dual inhibitor of LYPLA1 and the related LYPLA2 with IC50 of 17 and 30 nm. ML-211 could inhibit the serine hydrolase ABHD11 with IC50 of 10 nM but was over 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases. Synonyms: Methanone, [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-; [4-(1,1-Dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]methanone; {4-[Hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}[4-(2-methyl-2-propanyl)-1-piperidinyl]methanone; (4-(tert-butyl)piperidin-1-yl)(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)methanone. Grades: >98%. CAS No. 2205032-89-7. Molecular formula: C25H30N4O2. Mole weight: 418.53. | |
| ML213 | ML213 is a selective activator of KCNQ2 (Kv7.2) and KCNQ4 (Kv7.4) with > 80-fold selectivity against other related K+ channels, and enhances Kv7.2 and Kv7.4 channels with EC50s of 230 and 510 nM, respectively. Synonyms: N-(2, 4, 6-trimethylphenyl)bicyclo[2. 2. 1]heptane-3-carboxamide; N-mesitylbicyclo[2.2.1]heptane-2-carboxamide; ML213; ML 213; ML-213; CID-3111211; CID 3111211; CID3111211; AK174864; N-(2,4,6-Trimethylphenyl)-bicyclo[2.2.1]heptane-2-carboxamide. CAS No. 489402-47-3. Molecular formula: C17H23NO. Mole weight: 257.37. | |
| ML 213 | ML 213. Group: Biochemicals. Grades: Purified. CAS No. 489402-47-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML216 | Bloom (BLM) helicase is a DNA unwinding enzyme important for DNA repair in the homologous recombination pathway. Mutations of the BLM gene result in reduced BLM helicase activity that is associated with the rare genetic disorder, Bloom's Syndrome, and a predisposition to developing cancer. ML-216 is the first identified small molecule inhibitor of BLM helicase (IC50 = 1.8 μM) that is 28-fold selective against the related helicases RECQ1, RECQ5, and E. coli UvrD (IC50s ≥ 50 μM). At 25-50 μM, ML-216 has been shown to dose-dependently inhibit the proliferation of BLM-expressing PSNF5 fibroblast cells but not BLM-deficient PSNG13 fibroblast cells. Synonyms: ML 216; ML-216; CID-49852229; CID49852229; CID 49852229. Grades: >98%. CAS No. 1430213-30-1. Molecular formula: C15H9F4N5OS. Mole weight: 383.32. | |
| ML 218 hydrochloride | ML 218 hydrochloride is a T-type calcium channel inhibitor with IC50 values of 270 nM for Cav3.3 and 310 nM for Cav3.2. It has potential applications for the treatment of pain. Synonyms: ML218; ML 218; ML-218. 3,5-Dichloro-N-[[(1α,5α,6-exo,6α)-3-(3,3-dimethylbutyl)-3-azabicyclo[3.1.0]hex-6-yl]methyl]-benzamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 1346233-68-8. Molecular formula: C19H26Cl2N2O.HCl. Mole weight: 405.79. | |
| ML 218 hydrochloride | ML 218 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1346233-68-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 221 | ML 221. Group: Biochemicals. Grades: Purified. CAS No. 877636-42-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 221 | ML 221 is an apelin receptor antagonist with IC50 values of 0.70μM in a cAMP assay and 1.75 μM in β-arrestin assay. It has the potential to be used to treat or mediate the homeostasis of the cardiovascular system. Synonyms: ML221; ML 221; ML-221. 5-[(4-Nitrobenzoyl)oxy]-2-[(2-pyrimidinylthio)methyl]-4H-pyran-4-one. Grades: ≥99% by HPLC. CAS No. 877636-42-5. Molecular formula: C17H11N3O6S. Mole weight: 385.35. | |
| ML224 | ML224, a TSHR inverse agonist, has been found to reduce serum free T4 and thyroperoxidase in mice in in vivo study. IC50: 2.3 uM. Uses: Ml224 is a tshr inverse agonist that has been found to reduce serum free t4 and thyroperoxidase in mice in in vivo study. Synonyms: ML224; ML-224; ML 224; NCGC00242364; NCGC-00242364; NCGC 00242364; ANTAG3; ANTAG-3; ANTAG 3; MLS003370609; SCHEMBL14151304; CS-3824; NCGC00242364-01. Grades: 98%. CAS No. 1338824-21-7. Molecular formula: C31H31N3O5. Mole weight: 525.59. | |
| ML-226 | ML-226 is an inhibitor of α/β hydrolase domain-containing protein 11 (ABHD11) with 100-fold greater selectivity for ABHD11 over approximately 20 other serine hydrolases. It can be used as an anti-probe for ML-211. Synonyms: ML 226; ML226; (2-Ethylpiperidin-1-yl)-[4-[hydroxy(diphenyl)methyl]triazol-2-yl]methanone. Grades: ≥98%. CAS No. 2055172-43-3. Molecular formula: C23H26N4O2. Mole weight: 390.48. | |
| ML228 | HIF pathway activator (EC50 values are 1.23 and 1.4 μM for HRE gene reporter assay and HIF-1α nuclear translocation assay respectively); acts via chelation of iron, independently of PHD. Also exhibits > 80% inhibition of the human A3 receptor, dopamine transporter, μ receptor, hERG and 5-HT2B receptor, and rat sodium channel site 2, at a concentration of 10 μM. Synonyms: ML-228; ML 228; ML228; CID-46742353; CID 46742353; CID46742353. Grades: >98%. CAS No. 1357171-62-0. Molecular formula: C27H21N5. Mole weight: 415.49. | |
| ML 228 | ML 228. Group: Biochemicals. Grades: Purified. CAS No. 1357171-62-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-23 | ML-23 is a melatonin analogue. It is a potential clinical candidate for the treatment of Parkinson's disease. It produced a significant remission from MPTP-induced Parkinsonism and this effect did not abate when the treatment was withdrawn on all parameters. Uses: Ml-23 is a potential clinical candidate for the treatment of parkinson's disease. Synonyms: ML-23; ML23; ML 23; N-(3,5-Dinitrophenyl)-5-methoxy-1H-indole-3-ethanamine;N-(2,4-Dinitrophenyl)-5-methoxytryptamine;1H-Indole-3-ethanamine,N-(2,4-dinitrophenyl)-5-methoxy-;ML23;N-(2-(5-methoxy-1H-indol-3-yl)ethyl)-3,5-dinitroaniline. Grades: >98%. CAS No. 108929-03-9. Molecular formula: C17H16N4O5. Mole weight: 356.34. | |
| ML230 | ML230 (CID44640177; SID 88095709) is a selective inhibitor of ATP-binding cassette (ABC) transporter ABCG2 , and 36-fold selective for ABCG2 over ABCB1 with EC 50 s values of 0.13 μM and 4.65 μM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID44640177; SID 88095709. CAS No. 1776055-05-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111678. | |
| ML 233 | ML-233 is a novel apelin receptor agonist with EC50 value of 3.7 μM. Synonyms: ML 233; ML233; ML-233; (E)-4-Methyl-5-(((phenylsulfonyl)oxy)imino)-[1,1'-bi(cyclohexane)]-3,6-dien-2-one. Grades: ≥98% by HPLC. CAS No. 2080311-92-6. Molecular formula: C19H21NO4S. Mole weight: 359.44. | |
| ML 236A | It has the activity of inhibiting HMG-CoA reductase, and it is produced by the strain of Penicillum citrinum SANK. Synonyms: Compactin diol lactone; ML-236A; 6-(2-(1,2,6,7,8,8a-Hexahydro-8-hydroxy-2-methyl-1-naphthalenyl)ethyl)tetrahydro-4-hydroxy-2H-pyran-2-one; desmethylmonacolin J; Antibiotic ML 236A. CAS No. 58889-19-3. Molecular formula: C18H26O4. Mole weight: 306.40. | |
| ML240 | ML240 is a potent p97 inhibitor, inhibiting p97 ATPase with IC 50 value of 100 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346527-98-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19795. | |
| ML240 | ML240, a quinazoline derivative, has been found to be a p97 ATPase inhibitor and probably be effective against colon cancer and show antiproliferative activity in NCI-60 cancer cell lines. IC50: 100 nM. Uses: Ml240 has been found to be a p97 atpase inhibitor and probably be effective against colon cancer and show antiproliferative activity in nci-60 cancer cell lines. Synonyms: ML240; ML-240; ML 240. MLS003568129; KUC107871N; SMR002239184; 2-(2-amino-1H-benzo[d]imidazol-1-yl)-N-benzyl-8-methoxyquinazolin-4-amine; 2nd batch of KSC-16-270. Grades: 95%. CAS No. 1346527-98-7. Molecular formula: C23H20N6O. Mole weight: 396.44. | |
| ML 240 | ML 240. Group: Biochemicals. Grades: Purified. CAS No. 1346527-98-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML241 | ML241 is a selective p97 ATPase inhibitor and IC50 value is 100 nM. It can inhibit degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 may be a novel agent for the treatment of cancer. Uses: Anticancer. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine; ML241; ML-241; ML 241. Grades: 98%. CAS No. 1346528-06-0. Molecular formula: C23H24N4O. Mole weight: 372.46. | |
| ML241 HCl | ML241 is identified as a potent and selective inhibitors of p97 ATPase (IC(50)= 100 nM). ML241 inhibits degradation of a p97-dependent but not a p97-independent proteasome substrate in a dual-reporter cell line. ML241 could impair the endoplasmic-reticulum-associated degradation (ERAD) pathway. Synonyms: 2-(2H-benzo[b][1,4]oxazin-4(3H)-yl)-N-benzyl-5,6,7,8-tetrahydroquinazolin-4-amine hydrochloride; ML241; ML-241; ML 241; ML241 HCl; ML241 hydrochloride. CAS No. 2070015-13-1. Molecular formula: C23H25ClN4O. Mole weight: 408.93. | |
| ML243 (Cancer Stem Cell Inhibitor, ML243, (E) -N- (4, 5-Dihydrothiazol-2-yl) -3- (4-ethylphenyl) acrylamide, (2E)-N-(4,5-Dihydro-1,3-thiazol-2-yl)-3-(4-ethylphenyl)prop-2-enamide) | A cell-permeable, biologically stable, 4-ethyl substituted cinnamide analog that selectively exerts an inhibitory effect on breast cancer stem-like cells (EC50 = 2uM for epithelial-to-mesenchymal transition; HMLE_shEcad). Exhibits ~32-fold greater selectivity over isogenic control cells (EC50 = 64uM; HMLE cell line expressing shRNA against eGFPcells; HMLE_sh_eGFP). Displays desirable aqueous solubility (~11.5uM in PBS, pH 7.4) and excellent stability in human plasma and in glutathione solution. Shown to block the binding to a radio-labeled ligand to the Adenosine A2A Receptor (IC50 = 10uM), but does not affect 68 other targets studied. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| ML252 | ML252 is a selective and brain penetrant KCNQ2 inhibitor (Kv7.2; IC50 value 69 nM) used in vivo to study KCNQ2 pharmocology. Synonyms: AOB1824; ML252; AOB 1824; ML 252; AOB-1824; ML-252; (2S)-2-phenyl-N-(2-pyrrolidin-1-ylphenyl)butanamide hydrochloride. Grades: 99%. CAS No. 1392494-64-2. Molecular formula: C20H24N2O.HCl. Mole weight: 344.88. | |
| ML254 | ML254 is a potent mGlu 5 potentiator, with EC 50 and pEC 50 of 9.3 nM and 8.03 nM for rat mGlu 5 , respectively. ML254 can be used for researching schizophrenia [1]. ML254 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1428630-86-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-16654. | |
| ML264 | ML264 is a Krüppel-like factor 5 (KLF5) inhibitor with the potential to inhibits growth of colorectal cancer. It reduces EGR1 and KLF5 levels so that ML264 inhibits the MAPK pathway. in a cell-based assay for proliferation of DLD-1 cells: IC50 = 29 nM, in. Synonyms: (E)-3-(3-chlorophenyl)-N-[2-[(1,1-dioxothian-4-yl)-methylamino]-2-oxoethyl]prop-2-enamideML264; ML264; ML 264; MLS003874889SCHEMBL15605936SCHE MBL17045845CS-5628; CS 5628; CS5628HY-19994; HY 19994; HY19994SMR002531696SR-03000002171SR-03000002171-1(E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-. CAS No. 1550008-55-3. Molecular formula: C17H21ClN2O4S. Mole weight: 384.88. | |
| ML264 | ML264 is an antitumor agent that potently and selectively inhibits Krüppel-like factor five ( KLF5 ) expression. Uses: Scientific research. Group: Signaling pathways. CAS No. 1550008-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19994. | |
| ML277 | ML277, a sulfonylpiperidine compound, has been found to be a KCNQ1 K+ channel activator and could be used in the study of the activity of K+ channel in human cardiomyocytes. IC50: 270 nM (EC50). Uses: Ml277 has been found to be a kcnq1 k+ channel activator and could be used in the study of the activity of k+ channel in human cardiomyocytes. Synonyms: ML277; ML 277; ML-277; CHEMBL2070953; (2R)-N-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-1-(4-methylphenyl)sulfonylpiperidine-2-carboxamide; ML 277; 1401242-74-7; MLS003875054. Grades: 98%. CAS No. 1401242-74-7. Molecular formula: C23H25N3O4S2. Mole weight: 471.59. | |
| ML 277 | ML 277. Group: Biochemicals. Grades: Purified. CAS No. 1401242-74-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML281 | ML281, a quinoxalin derivative, has been found to be a STK33 inhibitor and could have probable effect against KRAS-dependent cancers. IC50: 14 nM. Uses: Ml281 has been found to be a stk33 inhibitor and could have probable effect against kras-dependent cancers. Synonyms: ML-281; ML-281; ML281. CHEMBL2204239; Bg-stk33-59; MLS003876599; BRD8942; BRD-8942. Grades: 98%. CAS No. 1404437-62-2. Molecular formula: C22H19N3O2S. Mole weight: 389.47. | |
| ML 281 | ML 281. Group: Biochemicals. Grades: Purified. CAS No. 1404437-62-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 289 | ML 289. Group: Biochemicals. Grades: Purified. CAS No. 1382481-79-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 289 | ML-289 is a negative allosteric modulator of mGlu3 with IC50 value of 0.66 μM. It displays 15-fold selectivity over mGlu2 and inactivity against mGlu5.1. Synonyms: VU0463597, VU 0463597, VU-0463597, ML-289, ML 289; ML289; [ (3R) -3- (Hydroxymethyl) -1-pipridinyl][4-[2- (4-methoxyphenyl) ethynyl]phenyl]methanone. Grades: ≥98% by HPLC. CAS No. 1382481-79-9. Molecular formula: C22H23NO3. Mole weight: 349.42. | |
| ML-290 | ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1). It increases cAMP accumulation and VEGF expression in cells that endogenously express human RXFP1. ML290 exhibits antifibrotic effects in liver fibrosis. Synonyms: ML 290; ML290; RXFP1 Agonist 8??; 2-[ (2-propan-2-yloxybenzoyl) amino]-N-[3- (trifluoromethylsulfonyl) phenyl]benzamide. Grades: ≥95%. CAS No. 1482500-76-4. Molecular formula: C24H21F3N2O5S. Mole weight: 506.5. | |
| ML-291 | ML-291 is a novel activator of the apoptotic arm of the unfolded protein response (UPR), but not the adaptive arm. It induces apoptosis in mouse embryonic fibroblasts overexpressing CHOP, but not in wild-type or CHOP knockout cells. Synonyms: ML 291; ML291; N-(4-((4-chloropiperidin-1-yl)sulfonyl)phenyl)-5-nitrofuran-2-carboxamide. Grades: ≥98%. CAS No. 1523437-16-2. Molecular formula: C16H16ClN3O6S. Mole weight: 413.8. | |
| ML 297 | ML 297 (VU 0456810) is a potent and selective GIRK 1/2 activator, with an EC 50 of 0.16 μM. ML 297 is potential for the treatment of epilepsy [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VU 0456810; CID 56642816. CAS No. 1443246-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110192. | |
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