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| Product | Description | |
|---|---|---|
| MK 996 | MK-996, an imidazopyridine derivative, has been found to be an angiotensin receptor antagonist that was once developed in the treatment of hypertension by Merck. Synonyms: MK996; MK 996; MK-996; L-159282; L 159282; L159282. CHEMBL293511; 3-((2'-(Benzoylaminosulfonyl)biphenyl-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo(4,5-b)pyridine; 3-((2'-(BENZOYLAMINOSULFONYL)BIPHENYL-4-YL)METHYL)-2-ETHYL-5,7-DIMETHYL-3H-IMIDAZO[4,5-B]PYRIDINE. Grades: 98%. CAS No. 157263-00-8. Molecular formula: C30H28N4O3S. Mole weight: 524.64. |  |
| MK-B 251 | MK-B 251 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: MKB251; MKB 251; MK-B251; MK B 251;MKB-251; MK-B-251; MK-B 251; 2-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]propan-2-amine;hydrochloride. Grades: ≥98%. CAS No. 40396-69-8. Molecular formula: C17H18ClF4N. Mole weight: 347.78. | |
| MKC-1 | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro-31-7453. CAS No. 125313-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13691. |  |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. Group: Inhibitors. Alternative Names: MKC1; MKC 1; MKC-1; R 440; R-440; R440; Ro 317453; Ro-317453; Ro317453. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. Appearance: Solid powder. Purity: >98%. IUPACName: 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Canonical SMILES: O=C (C (C1=CN (C)C2=C1C=CC=C2)=C3C4=CN (C)C5=C4C=CC ([N+] ([O-])=O)=C5)NC3=O. Catalog: ACM125313920. |  |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus. Synonyms: MKC1; MKC 1; R 440; Ro 317453; Ro-317453; Ro317453; 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. | |
| MKC-3946 | MKC3946 is a potent and soluble IRE1α inhibitor. MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. Group: Inhibitors. Alternative Names: MKC-3946; MKC 3946; MKC3946. CAS No. 1093119-54-0. Molecular formula: C21H20N2O3S. Mole weight: 380.46. Appearance: Solid powder. Purity: >98%. IUPACName: 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde. Canonical SMILES: O=CC1=C (C=CC2=C1C=CC (C3=CC=C (S3)C (N4CCN (CC4)C)=O)=C2)O. Catalog: ACM1093119540. | |
| MKC-3946 | MKC-3946 is a potent inhibitor of inositol-requiring enzyme 1α (IRE1α). It inhibits XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. MKC-3946 leads to modest growth inhibition in MM cells but has no effect on normal mononuclear cells in vitro. Synonyms: MKC-3946; MKC 3946; MKC3946; 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde. Grades: >98%. CAS No. 1093119-54-0. Molecular formula: C21H20N2O3S. Mole weight: 380.462. | |
| MKC8866 | MKC8866 Inhibitor. Uses: Scientific use. Product Category: T15594. CAS No. 1338934-59-0. |  |
| MKC-8866 | MKC-8866, also known as IRE1-IN-8866, is an inhibitor of IRE1 RNase activity. MKC8866 strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic analysis reveal that IRE1α-XBP1s pathway activity is required for c-MYC signaling, one of the most highly activated oncogenic pathways in PCa. Group: Inhibitors. Alternative Names: MKC-8866; MKC 8866; MKC8866; IRE1-IN-8866; IRE1IN8866; IRE1 IN 8866; IRE1-IN8866; IRE1-IN 8866; IRE1IN-8866; IRE1IN 8866. CAS No. 1338934-59-0. Molecular formula: C18H19NO7. Mole weight: 361.35. Appearance: Solid powder. Purity: >98%. IUPACName: 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde. Canonical SMILES: O=CC1=C (O)C (OC)=CC2=C1OC (C (CC (N3CCOCC3)=O)=C2C)=O. Catalog: ACM1338934590. | |
| MKI-833 | MKI 833 is a small molecule inhibitor of the MEK/MAPK pathway. Synonyms: Balamapimod; MKI 833; MKI833; 3-Quinolinecarbonitrile, 4-[[3-chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl]amino]-6-methoxy-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-. CAS No. 863029-99-6. Molecular formula: C30H32ClN7OS. Mole weight: 574.14. | |
| MKT 077 | MKT-077 is a cationic rhodacyanine dye. It shows antiproliferative activity against cancer cell lines with EC50s value of 1.4-2.2 μM in vitro through its ability to inhibit members of the heat shock protein 70 family of molecular chaperones. Synonyms: MKT-077; MKT 077; MKT077; FJ-776; FJ 776; FJ776; 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride. Grades: ≥98% by HPLC. CAS No. 147366-41-4. Molecular formula: C21H22ClN3OS2. Mole weight: 432. | |
| MKT 077 | MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells.Biological Activity:Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Group: Biochemicals. Alternative Names: 1-Ethyl-2- [ [3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene] methyl] -pyridinium Chloride; FJ 776. Grades: Highly Purified. CAS No. 147366-41-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?OS??; Ci, Molecular Weight: 441.01. US Biological Life Sciences. |  Worldwide |
| ML00253764 | ML00253764 is a selective melanocortin receptor 4 ( MC4R ) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681847-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124740. | |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride is a MC4 receptor antagonist with IC50 value of 320nM. It may be used to counteract the effects of cachexia in cancer patients. Synonyms: ML 00253764 hydrochloride; ML00253764 hydrochloride; ML-00253764 hydrochloride; 2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 1706524-94-8. Molecular formula: C18H18BrFN2O.HCl. Mole weight: 413.71. | |
| ML-030 | ML-030, a triazolothiadiazine, is a potent PDE4 inhibitor in a cell-based cyclic nucleotide-gated cation channel biosensor assay (EC50 = 18.7 nM), with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively. Synonyms: ML-030; ML 030; ML030; CID-11757146; CID 11757146; CID11757146. 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine. CAS No. 1013750-77-0. Molecular formula: C20H20N4O4S. Mole weight: 412.46. | |
| ML-031 | ML-031 is a S1P2 agonist with EC50 value of 1 μM in a S1P reporter assay. Synonyms: ML 031; ML031; CID-2113511; 1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione. Grades: ≥95%. CAS No. 852230-33-2. Molecular formula: C19H20N2O3. Mole weight: 324.4. | |
| ML095 | ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-25067483. CAS No. 1135318-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128000. | |
| ML-095 hydrochloride | ML-095 is an inhibitor of placental alkaline phosphatase (PLAP) with IC50 value of 3.7 μM. Synonyms: ML-095 HCl; ML 095 hydrochloride; ML095 hydrochloride; CID-25067483; 1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone hydrochloride. Grades: ≥98%. CAS No. 1135318-57-8. Molecular formula: C13H14N2O3·HCl. Mole weight: 282.7. | |
| ML-097 | ML-097 is a pan activator of Ras-related GTPases. Synonyms: ML 097; ML097; CID-2160985; 2-[(2-bromophenyl)methoxy]benzoic acid; 2-[(2-bromobenzyl)oxy]benzoic acid. Grades: ≥95%. CAS No. 743456-83-9. Molecular formula: C14H11BrO3. Mole weight: 307.1. | |
| ML-098 | ML-098, also called as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) with selectivity without disrupting related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). Synonyms: 1-[2-(2,5-dimethylphenoxy)ethyl]indole-3-carboxylic acid; ML 098; ML098; CID-7345532; CID 7345532; CID7345532. CAS No. 878978-76-8. Molecular formula: C19H19NO3. Mole weight: 309.36. | |
| ML-099 | ML-099 is a pan activator of Ras-related GTPases. Synonyms: ML 099; ML099; CID-888706; 2-[(2-Phenylethyl)thio]nicotinic acid. Grades: ≥98%. CAS No. 496775-95-2. Molecular formula: C14H13NO2S. Mole weight: 259.3. | |
| ML-10 | ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18 F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216897-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76573. | |
| ML 10302 | ML 10302 is a potent agonist 5-HT4 receptor with K i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148868-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14441. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride is a 5-HT4 agonist with EC50 value of 4 nM. It can increase sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibit progastrokinetic effects in vivo. Synonyms: ML-10302 HCl; ML-10302; ML 10302; ML10302. 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride. Grades: ≥99% by HPLC. CAS No. 186826-17-5. Molecular formula: C15H21ClN2O3.HCl. Mole weight: 349.25. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 186826-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML115 | ML115 is a molecular probe of the signal transducer and activator of transcription ( STAT3 ). ML115 is a STAT3 agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111152. | |
| ML-115 | ML-115 is a potent, cell-permeable STAT3 activator with EC50 value of 2 nM. It is inactive against the related STAT1 and NFκB anti-targets. ML-115 exhibits no cytotoxicity in the parental cell lines in the STAT3 assay (HT-1080) and STAT1 assay (NIH-3T3). Synonyms: ML115; ML 115; 3-Isoxazolecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-; N-(4-Chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide. Grades: ≥98%. CAS No. 912798-42-6. Molecular formula: C15H15ClN2O4. Mole weight: 322.74. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride is an ATP-competitive IKK2-selective inhibitor with IC50 value of 60 nM at 50 μM ATP. It can inhibit paw swelling, bone and cartilage degradation. Synonyms: ML 120B dihydrochloride; ML120B dihydrochloride; ML-120B dihydrochlorideN-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782573-78-7. Molecular formula: C19H15ClN4O2.2HCl. Mole weight: 439.72. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML130 | ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. Synonyms: ML 130; ML-130; Nodinitib-1; Noditinib-1; 1-Tosyl-1H-benzo[d]imidazol-2-amine. Grades: >98%. CAS No. 799264-47-4. Molecular formula: C14H13N3O2S. Mole weight: 287.34. | |
| ML 130 | ML 130. Group: Biochemicals. Grades: Purified. CAS No. 799264-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-132 | ML132, also known as CID-4462093 or NCGC-00183434, is the most potent caspase 1 inhibitor reported to date. It also possesses a unique selectivity pattern relative to other reported caspase inhibitors. Synonyms: NCGC 00185682; ML132; ML 132; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-L-prolinamide; L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-. Grades: ≥98%. CAS No. 1230628-71-3. Molecular formula: C22H28ClN5O5. Mole weight: 477.94. | |
| ML133 HCl | ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. Synonyms: ML133 hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride. Grades: >98%. CAS No. 1222781-70-5. Molecular formula: C19H19NO.HCl. Mole weight: 313.82. | |
| ML 133 hydrochloride | ML 133 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1222781-70-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML133 hydrochloride | ML133 hydrochloride is a selective K ir 2 family channels inhibitor, with an IC 50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222781-70-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100230A. | |
| ML141 | ML141 is a potent, selective and reversible non-competitive inhibitor of Rho family GTPase cdc42 with IC50 of 200 nM. Synonyms: Ro111163; Ro-111163; Ro 111163; ML-141; ML 141; ML141; CID2950007; CID-2950007; CID 2950007. Grades: >98%. CAS No. 71203-35-5. Molecular formula: C22H21N3O3S. Mole weight: 407.49. | |
| ML 141 | ML 141. Group: Biochemicals. Grades: Purified. CAS No. 71203-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 145 | ML 145 is a GPR35 orphan receptor antagonist with IC50 value of 20.1 nM. It can be used in the treatment of disorders affecting the stomach as well as the immune system. Synonyms: ML 145; ML145; ML-145; 2-Hydroxy-4-[4-(5Z)-5-[(E)-2-methyl-3-phenylprop-2-enylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoylamino]benzoic acid. Grades: ≥98% by HPLC. CAS No. 1164500-72-4. Molecular formula: C24H22N2O5S2. Mole weight: 482.57. | |
| ML 145 | ML 145. Group: Biochemicals. Grades: Purified. CAS No. 1164500-72-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-148 | ML-148 is a potent and selective inhibitor of 15-hydroxy prostaglandin dehydrogenase (15-PGDH). Synonyms: ML 148; ML148; [1-(3-methylphenyl)benzimidazol-5-yl]-piperidin-1-ylmethanone. Grades: ≥98%. CAS No. 451496-96-1. Molecular formula: C20H21N3O. Mole weight: 319.4. | |
| ML 154 | ML 154 is a neuropeptide S receptor antagonist. It has the potential to be used in the treatment of sleep, anxiety and addiction disorders. Synonyms: NCGC 84; NCGC84; NCGC-84; ML 154; ML154; ML-154; NCGC00185684. 3-(Diphenylphosphinothioyl)-2-methyl-1-[(2E)-3-phenyl-2-propen-1-yl]imidazo[1,2-a]pyridinium bromide. Grades: ≥99% by HPLC. CAS No. 1345964-89-7. Molecular formula: C29H26N2PS.Br. Mole weight: 545.47. | |
| ML 154 | ML 154. Group: Biochemicals. Grades: Purified. CAS No. 1345964-89-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 161 | Inhibitor of protease-activated receptor 1 (PAR1)-mediated platelet activation (IC50 = 0.26 muM for the inhibition of platelet P-selectin expression on human platelets). Thought to act allosterically. Also inhibits thrombin-induced platelet activation. Synonyms: ML-161; ML161; Parmodulin 2; 2-Bromo-N-[3-[(1-oxobutyl)amino]phenyl]benzamide. CAS No. 423735-93-7. Molecular formula: C17H17BrN2O2. Mole weight: 361.24. | |
| ML 161 | ML 161 is a diaminobenzene derivative that acts as a selective inhibitor of platelet activation at protease-activated receptor 1 (PAR1). ML 161 has also been shown to inhibit thrombin-induced platelet activation. Group: Biochemicals. Alternative Names: ML161; 2-Bromo-N- [3- [ (1-oxobutyl) amino] phenyl] benzamide. Grades: Highly Purified. CAS No. 423735-93-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML162 | ML162 Inhibitor. Uses: Scientific use. Product Category: T8970. CAS No. 1035072-16-2. | |
| ML-162 | ML-162 is a GPX4 inhibitor that selectively kills cells induced to express mutant RAS. GPX4 is a regulator of ferroptosis (iron-dependent, non-apoptotic cell death). Synonyms: ML 162; ML162; 2-[(Chloroacetyl)(3-chloro-4-methoxyphenyl)amino]-N-(2-phenylethyl)-2-thien-2-ylacetamide. Grades: ≥95%. CAS No. 1035072-16-2. Molecular formula: C23H22Cl2N2O3S. Mole weight: 477.4. | |
| ML167 | ML167 is a highly selective Cdc2-like kinase 4 (Clk4) inhibitor with IC50 of 136 nM, >10-fold selectivity for closely related kinases Clk1-3 and Dyrk1A/1B. Synonyms: CID44968231; NCGC00188654; [5-[4-[(5-methyl-2-furanyl)methylamino]-6-quinazolinyl]-2-furanyl]methanol; 2-Furanmethanol, 5-[4-[[(5-methyl-2-furanyl)methyl]amino]-6-quinazolinyl]-. Grades: >98%. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. | |
| ML167 | ML167 is the first highly selective inhibitor of of Cdc2-like kinase 4 (Clk4) with an IC50 of 136 nM for Clk4. The Cdc2-like kinases (Clk 's) and the dual-specificity tyrosine phosphorylation-regulated kinases (Dyrk 's) have specified roles in gene splicing. Specifically, the Clk class of enzymes has been shown to phosphorylate the serine- and arginine-rich (SR) proteins, which are a major component of the spliceosome. Group: Inhibitors. Alternative Names: ML167; ML-167; ML 167; CID 44968231; CID44968231; CID-44968231; NCGC00188654; NCGC-00188654; NCGC 00188654. CAS No. 1285702-20-6. Molecular formula: C19H17N3O3. Mole weight: 335.36. Appearance: Solid powder. Purity: >98%. IUPACName: (5-(4-(((5-methylfuran-2-yl)methyl)amino)quinazolin-6-yl)furan-2-yl)methanol. Canonical SMILES: OCC1=CC=C (C2=CC3=C (NCC4=CC=C (C)O4)N=CN=C3C=C2)O1. Catalog: ACM1285702206. | |
| ML 171 | ML 171. Group: Biochemicals. Grades: Purified. CAS No. 6631-94-3. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| ML-178 | ML-178 is a selective S1P4 activator with EC50 value of 46.3 nM without effect against S1P1, S1P2, S1P3, and S1P5. Synonyms: ML 178; ML178; CID 44620892; CYM 50179; SID 87544119; 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]pyridine. Grades: ≥95%. CAS No. 1355026-47-9. Molecular formula: C13H9Br2Cl2NO2. Mole weight: 441.9. | |
| ML 179 | ML 179 is a liver receptor homolog 1 inverse agonist with IC50 value of 320 nM. Synonyms: ML 179; ML179; ML-179; 3-Cyclohexyl-6-[4-[3-(trifluoromethyl)phenyl]piperazin-1-yl]-1H-pyrimidine-2,4-dione. Grades: ≥99% by HPLC. CAS No. 1883548-87-5. Molecular formula: C21H25F3N4O2. Mole weight: 422.44. | |
| ML 179 | ML 179. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 18 | ML 18 is a bombesin receptor subtype 3 (BRS-3) antagonist (IC50 = 4.8 μM) and binds GRPR (IC50 = 16 μM) with potential in combating lung cancer cells. Synonyms: ML-18; ML 18; ML18. 1H-Indole-3-propanamide, N-[[1- (4-methoxyphenyl) ?cyclohexyl]?methyl]?-α -[[[ (4-nitrophenyl) ?amino]?carbonyl]?amino]?-, (αS)?-; (αS)-N-[[1-(4-Methoxyphenyl)cyclohexyl]methyl]-α-[[[(4-nitrophenyl)amino]carbonyl]amino]-1H-indole-3-propanamide. CAS No. 1422269-30-4. Molecular formula: C32H35N5O5. Mole weight: 569.65. | |
| ML-180 | ML-180 is an inverse agonist of liver receptor homolog-1 (LRH-1) that inhibits cell proliferation. Synonyms: ML 180; ML180; CID-3238389; SR1848; 6-[4-(3-Chlorophenyl)-1-piperazinyl]-3-cyclohexyl-1H-pyrimidine-2,4-dione. Grades: ≥98%. CAS No. 863588-32-3. Molecular formula: C20H25ClN4O2. Mole weight: 388.9. | |
| ML-180 | ML-180 (SR1848) is a potent orphan nuclear receptor liver receptor homolog 1 (LRH-1; NR5A2 ) inverse agonist with an IC 50 of 3.7 μM. ML-180 is inactive for steroidogenic factor-1 (SF-1; NR5A1 ; IC 50 >10 μM). ML-180 has the potential for LRH-1-dependent cancers [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SR1848. CAS No. 863588-32-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-115613. | |
| ML188 | ML188, a first in class probe, is a selective non-covalent SARS-CoV 3CLpro inhibitor with an IC50 of 1.5 μM. Antiviral activity. Group: Inhibitors. Alternative Names: (R)-N-(4-(tert-Butyl)phenyl)-N-(2-(tert-butylamino)-2-oxo-1-(pyridin-3-yl)ethyl)furan-2-carboxamide. CAS No. 1417700-13-0. Molecular formula: C26H31N3O3. Mole weight: 433.55. Appearance: White to off-white solid. Purity: 0.98. IUPACName: N-[(1R)-2-(tert-butylamino)-2-oxo-1-pyridin-3-ylethyl]-N-(4-tert-butylphenyl)furan-2-carboxamide. Canonical SMILES: CC (C) (C)C1=CC=C (C=C1)N ([C@H] (C2=CN=CC=C2)C (=O)NC (C) (C)C)C (=O)C3=CC=CO3. Catalog: ACM1417700130. | |
| ML 190 | ML 190 is a κ opioid receptor antagonist with IC50 value of 120 nM. Synonyms: ML 190; ML190; ML-190; N-[3-[4-(4-Methoxyphenyl)-1-piperazinyl]propyl]-1-methyl-6-oxopyrido[2,3-e]pyrrolo[1,2-a]pyrazine-5(6H)-acetamide. Grades: ≥98% by HPLC. CAS No. 1355244-02-8. Molecular formula: C27H32N6O3. Mole weight: 488.58. | |
| ML 190 | ML 190. Group: Biochemicals. Grades: Purified. CAS No. 1355244-02-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-191 | ML-191 is a GPR55 antagonist inhibiting LPI-induced phosphorylation of ERK1/2 and blocking receptor-dependent translocation of PKCβII. Synonyms: ML 191; ML191; CCG-152883; CID-23612552; 3-[1-[[1-(4-Methylphenyl)cyclopropyl]-oxomethyl]-4-piperidinyl]-5-phenyl-1,3,4-oxadiazol-2-one. Grades: ≥98%. CAS No. 931695-79-3. Molecular formula: C24H25N3O3. Mole weight: 403.5. | |
| ML192 | ML192 is a selective ligands for GPR55 with 1080 nM potency for GPR55 and >45-fold antagonist and agonist selectivity against GPR35, CB1 and CB2. Uses: Potent and selective antagonist for gpr55. Synonyms: ML192; ML 192; ML-192; CID1434953; CID-1434953; CID 1434953; MLS000526305. furan-2-yl(4-(2-methyl-5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4-yl)piperazin-1-yl)methanone. Grades: ≥98%. CAS No. 460331-61-7. Molecular formula: C20H22N4O2S. Mole weight: 382.48. | |
| ML 193 | ML 193 is a GPR55 antagonist with IC50 value of 221 nM. Synonyms: ML-193; ML 193; ML193; CID 1261822; CID-1261822; CID1261822; N-[4-[[(3,4-Dimethyl-5-isoxazolyl)amino]sulfonyl]phenyl]-6,8-dimethyl-2-(2-pyridinyl)-4-quinolinecarboxamide. Grades: ≥98% by HPLC. CAS No. 713121-80-3. Molecular formula: C28H25N5O4S. Mole weight: 527.59. | |
| ML 202 | ML 202. Group: Biochemicals. Grades: Purified. CAS No. 1221186-52-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML204 | ML204 is a novel and potential TRPC4 Channel inhibitor. ML204 inhibited TRPC4β-mediated intracellular Ca(2+) rise with an IC(50) value of 0.96 μm and exhibited 19-fold selectivity against muscarinic receptor-coupled TRPC6 channel activation. Synonyms: 4-Methyl-2-piperidin-1-ylquinoline; ML204; ML 204; ML-204. Grades: > 98%. CAS No. 5465-86-1. Molecular formula: C15H18N2. Mole weight: 226.323. | |
| ML204 | ML204 is a potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 5465-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949. | |
| ML 204 | ML 204. Group: Biochemicals. Grades: Purified. CAS No. 5465-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML204 hydrochloride | ML204 hydrochloride is a novel, potent, selective TRPC4/TRPC5 channel inhibitor, with at least 19-fold selectivity against TRPC6 and no appreciable effect on all other TRP channels, nor on voltage-gated sodium, potassium, or Ca 2+ channels [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-10-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12949A. | |
| ML 204 (Selective TRPC4 Blocker, 4-Methyl-2-(1-piperidinyl)quinoline ) | Blocker of TRPC4 channels (IC50 values are 0.96 and 2.6um in fluorescent and electrophysiological assays, respectively). Exhibits 19-fold selectivity against TRPC6 and 9-fold selectivity against TRPC5; displays no significant activity at TRPV1, TRPV3, TRPA1 and TRPM8 channels at concentrations up to 22um. Group: Biochemicals. Grades: Highly Purified. CAS No. 5465-86-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| ML 210 | ML 210 is a selective RAS inhibitor that kills cells induced to express mutant RAS. ML210 exhibits nanomolar potency against two HRASG12V expressing cell lines and 4-fold selectivity against two control cell lines not expressing HRASG12V. Synonyms: CID 49766530; CID-49766530; CID49766530; ML-210; ML 210; ML210. [4-[bis(4-chlorophenyl)methyl]-1-piperazinyl](5-methyl-4-nitro-3-isoxazolyl)-methanone. Grades: 99%. CAS No. 1360705-96-9. Molecular formula: C22H20Cl2N4O4. Mole weight: 475.32. | |
| ML-211 | ML-211 is a dual inhibitor of LYPLA1 and the related LYPLA2 with IC50 of 17 and 30 nm. ML-211 could inhibit the serine hydrolase ABHD11 with IC50 of 10 nM but was over 50-fold selective for LYPLA in a panel of 20 additional serine hydrolases. Synonyms: Methanone, [4-(1,1-dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]-; [4-(1,1-Dimethylethyl)-1-piperidinyl][4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl]methanone; {4-[Hydroxy(diphenyl)methyl]-2H-1,2,3-triazol-2-yl}[4-(2-methyl-2-propanyl)-1-piperidinyl]methanone; (4-(tert-butyl)piperidin-1-yl)(4-(hydroxydiphenylmethyl)-2H-1,2,3-triazol-2-yl)methanone. Grades: >98%. CAS No. 2205032-89-7. Molecular formula: C25H30N4O2. Mole weight: 418.53. | |
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