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| Product | Description | |
|---|---|---|
| MK-7145 dihydrochloride | MK-7145 is a potent, selective and orally active ROMK inhibitor for the treatment of hypertension and heart failure. MK-7145 is selective against other cardiac ion channels such as Cav1.2 and Nav1.5 (IC50 > 30 μM). Synonyms: MK-7145 dihydrochloride; MK 7145 dihydrochloride; MK7145 dihydrochloride. Grades: 98%. CAS No. 1255204-85-3. Molecular formula: C26H30N2O6.2HCl. Mole weight: 544.534. |  |
| MK-7246 | This active molecular is a selective chemoattractant receptor-homologous molecule expressed on T-helper type 2 cells (CRTH2) antagonist and is used for the treatment of respiratory tract disorders originated by Merck & Co. CRTH2 is a G protein-coupled receptor that has been reported to modulate inflammatory responses in animal models of asthma, allergic rhinitis and atopic dermatitis. No recent reports of development identified for phase-I development in Respiratory-tract-disorders in USA were published yet. Uses: Respiratory tract disorders. Synonyms: MK-7246; MK 7246; MK7246; (7R)-7-[[(4-Fluorophenyl)sulfonyl]methylamino]-6,7,8,9-tetrahydro-pyrido[1,2-a]indole-10-acetic Acid. Grades: 98%. CAS No. 1218918-62-7. Molecular formula: C21H21FN2O4S. Mole weight: 416.47. | |
| MK-761 | MK-761 has beta adrenoceptor antagonist and vasodilating properties in a single molecule. It has beta adrenoceptor blocking activity in the isolated cat heart papillary muscle and isolated rat atria in vitro. Uses: Mk-761 has beta adrenoceptor antagonist and vasodilating properties. Synonyms: MK-761; MK 761; MK761;(S)-2-(3-(tert-butylamino)-2-hydroxypropoxy)nicotinonitrile;2-[3-(Tert-butylamino)-2-hydroxypropoxy]pyridine-3-carbonitrile. Grades: 98%. CAS No. 65321-41-7. Molecular formula: C13H19N3O2. Mole weight: 249.31. | |
| MK-761 free base | MK-761 free base is a potent and orally active β2-adrenergic blocker. MK-761 free base shows antihypertensive and positive inotropic effects. MK-761 free base shows vasodilating properties [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 65321-41-7. Pack Sizes: 1 mg. Product ID: HY-123449. |  |
| MK-7622 | MK-7622 is a cholinesterase inhibitor under evaluation for the treatment of Alzheimer's disease. No studies have been published on this compound in the peer-reviewed literature or other publicly available documents. I. Synonyms: MK7622; MK 7622; MK-7622. Grades: 98%. CAS No. 1227923-29-6. Molecular formula: C25H25N3O2. Mole weight: 399.49. | |
| MK-771 | MK-771 is an analog of the Thyrotropin Releasing Hormone (TRH). It is a therapeutic agent. It may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Uses: Mk-771 is a therapeutic agent. it may be useful in combating some of the withdrawal symptoms in opiate-dependent subjects. Synonyms: MK771; MK 771; (S)-3-((S)-3-(1H-imidazol-4-yl)-2-((S)-6-oxopiperidine-2-carboxamido)propanoyl)thiazolidine-4-carboxamide. Grades: 98%. CAS No. 66537-55-1. Molecular formula: C16H22N6O4S. Mole weight: 394.45. | |
| MK7725 | MK7725 is a potent, selective bombesin receptor subtype-3 agonist. It is used for the treatment of obesity. Uses: Mk7725 is used for the treatment of obesity. Synonyms: MK7725; MK 7725; MK-7725; 2-[3-[6-[4-(trifluoromethoxy)phenyl]sulfonyl-2-(trifluoromethyl)-5,11-dihydropyrido[3,2-c][1,5]benzodiazepin-7-yl]-1,2,4-oxadiazol-5-yl]propan-2-ol. Grades: >98 %. CAS No. 1034152-95-8. Molecular formula: C25H19F6N5O5S. Mole weight: 615.50. | |
| MK785 | MK785, an imidazol derivative, has been found to inhibit the formation of aortic histamine through influencing the aortic histidine decarboxylase at some extent. Synonyms: 2-hydrazinyl-3-(1h-imidazol-5-yl)propanoic acid; MK-785; MK 785; MK785; AC1Q5SMC; 2-Hydrazino-3-(4(5)-imidazole)propionic acid. Grades: 98%. CAS No. 14760-71-5. Molecular formula: C6H10N4O2. Mole weight: 170.17. | |
| MK789 | MK-789 is a dehydropeptidase I inhibitor. Synonyms: MK789; MK 789; MK-789; (E)-2-(2,2-dimethylcyclopropanecarboxamido)oct-2-enoic acid. Grades: 98%. CAS No. 85394-14-5. Molecular formula: C14H23NO3. Mole weight: 253.34. | |
| MK-7924 | MK-7924, isolated from Coronophora gregaria, is an antibiotic with nematocidal effect. And the reproductive growth tests showed that the effective concentration against Caenorhabditis elegane was 100 μg/mL. Molecular formula: C34H58O13. Mole weight: 674.81. | |
| MK800-62F1 | MK800-62F1 is produced by the strain of Streptomyces diastochromogenes MK 800-62F1. It is used to inhibit H2O2-induced apoptosis in MS-1 cells (NCI-H) and Jurkat cells (TCL-H), and camptothecin-induced apoptosis in Jurkat cells. Molecular formula: C35H58O8. Mole weight: 606.83. | |
| MK-8033 | MK8033 is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer. Synonyms: MK-8033; MK 8033; MK8033. Grades: >98%. CAS No. 1001917-37-8. Molecular formula: C25H21N5O3S. Mole weight: 471.53. | |
| MK-8033 hydrochloride | MK-8033 binds 3-fold more tightly to phosphorylated c-Met kinase domain (Kd= 3.2 nM) than to its unphosphorylated counterpart (Kd = 10.4 nM). Signigicantly, MK-8033 potently inhibits kinase activity of three oncogenic c-Met activation loop mutants, Y1230C, Y1230H, and Y1235D (IC50s ranging from 0.6 to 1 nM at 50 uM ATP) in addition to other c-Met activating mutants N1100Y and M1250T. MK-8033 potently inhibited GTL-16 proliferation with an IC50 of 582 ± 30 nM. By contrast the HCT116 cell line, which does not harbor basal c-Met activation, was not inhibited by MK-8033 (IC50 > 10000 nM) [1]. MK-8033 radiosensitized the high-c-Met-expressing EBC-1 and H1993 cells but not the low-c-Met...anized 1 h after dosing and tested for p-Met (Y1349) in tumors and MK-8033 concentrations in plasma. At 100 mg/kg,essentially complete inhibition of p-Met (Y1349) was achieved. An in vivo IC50 of 1.3 uM was deduced from the relationship between plasma MK-8033 level and Met pY1349. Treatment with escalating dosed of MK-8033 for 21 days lead to antitumor efficacies in a dose-dependent manner. Dosing at 3, 10, 30, and 100 mg/kg resulted in 22, 18, 57, and 86% tumor growth inhibition, respectively, relative to tumor from vehicle-treated mice. Synonyms: MK8033 hydrochloride; MK 8033 hydrochloride. Grades: >98%. CAS No. 1283000-43-0. Molecular formula: C25H22ClN5O3S. Mole weight: 507.99. | |
| MK-8189 | MK-8189 is a potent, orally active and selective PDE10A inhibitor with a K i value of 29 pM. MK-8189 can be used in research of schizophrenia [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1424371-93-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153093. | |
| MK-8245 | MK-8245 is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Synonyms: 4-(2-Bromo-5-fluorophenoxy)-1-[5-(2H-tetrazol-5-yl)-3-isoxazolyl]piperidine; MK-8245; MK8245; MK8245. Grades: 0.98. CAS No. 1030612-90-8. Molecular formula: C17H16BrFN6O4. Mole weight: 467.25. | |
| MK-8245 | MK-8245. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1030612-90-8. Molecular Formula: C17H16BrFN6O4. Mole Weight: 467.254. Catalog: APB1030612908. |  |
| MK-8245 | MK-8245 is a potent, liver-targeted stearoyl-CoA desaturase (SCD) inhibitor, with IC 50 s of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with antidiabetic and antidyslipidemic efficacy [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1030612-90-8. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13070. | |
| MK-8245 Trifluoroacetate | MK-8245 trifluoroacetate is a liver-targeting inhibitor of stearoyl-CoA desaturase (SCD) with IC50 of 1 nM for human SCD1 and 3 nM for both rat SCD1 and mouse SCD1, with anti-diabetic and anti-dyslipidemic efficacy. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415559-41-9. Pack Sizes: 1 mg. Product ID: HY-13077. | |
| MK-8245 Trifluoroacetate | MK-8245 Trifluoroacetate, a phenoxy piperidine isoxazole derivative, is a liver-targeted stearoyl-CoA desaturase (SCD) inhibitor that has the potential for treatment of dyslipidemia and diabetes. IC50: human SCD1= 1 nM; rat SCD1 and mouse SCD1= 3 nM. Uses: Antidiabetic; antidyslipidemic. Synonyms: MK-8245 Trifluoroacetate; MK 8245 Trifluoroacetate; MK8245 Trifluoroacetate; 2-[5-[3-[4-(2-bromo-5-fluorophenoxy)piperidin-1-yl]-1,2-oxazol-5-yl]tetrazol-2-yl]acetic acid;2,2,2-trifluoroacetic acid; MK-8245 (Trifluoroacetate); 1415559-41-9; 2,2,2-Trifluoroacetic acid compound with 2-(5-(3-(4-(2-bromo-5-fluorophenoxy)piperidin-1-Yl. CAS No. 1415559-41-9. Molecular formula: C19H17BrF4N6O6. Mole weight: 581.28. | |
| MK-8353 | MK-8353 is an orally available ERK1/2 inhibitor. It exhibited antitumor activity in patients with BRAFV600-mutant melanoma. Synonyms: (3S)-3-(methylthio)-1-[2-[4-[4-(1-methyl-1,2,4-triazol-3-yl)phenyl]-3,6-dihydro-2H-pyridin-1-yl]-2-oxoethyl]-N-[3-(6-propan-2-yloxy-3-pyridinyl)-1H-indazol-5-yl]-3-pyrrolidinecarboxamide. CAS No. 1184173-73-6. Molecular formula: C37H41N9O3S. Mole weight: 691.84. | |
| MK-8527 | MK-8527 is an orally active HIV inhibitor and nucleoside reverse transcriptase translocation inhibitor ( NRTTI ) with antiviral activity. MK-8527 has a similar inhibitory mechanism to ISL (HY-104012) [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1810869-23-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-158128. | |
| MK-8617 | MK-8617 is a potent and selective pan-inhibitor of Hypoxia-inducible factor prolyl hydroxylase 1-3 (HIF PHD1-3) (PHD1: IC50 = 1.0 nM; PHD2: IC50 =1.0nM; PHD3: IC50 = 14nM) commonly used for the treatment of Anemia, a disease caused by inadequate red blood cells (RBCs) or hemoglobin (Hb). Synonyms: MK-8617; MK 8617; MK8617; UNII-39RRC0G27V; 39RRC0G27V; SCHEMBL3407165; AKOS030622836; N-[bis(4-methoxyphenyl)methyl]-6-oxo-2-pyridazin-3-yl-1H-pyrimidine-5-carboxamide. Grades: 99.39 %. CAS No. 1187990-87-9. Molecular formula: C24H21N5O4. Mole weight: 443.45. | |
| MK-8718 | MK-8718 has been found to be a HIV protease inhibitor and could be studied in HIV research. Synonyms: MK-8718; MK 8718; MK8718; ((3S,6R)-6-(2-(3-((2S,3S)-2-amino-3-(4-chlorophenyl)-3-(3,5-difluorophenyl)propanamido)-5-fluoropyridin-4-yl)ethyl)morpholin-3-yl)methyl (2,2,2-trifluoroethyl)carbamate. Grades: 98%. CAS No. 1582729-24-5. Molecular formula: C30H30ClF6N5O4. Mole weight: 674.04. | |
| MK-8718 HCl | The hydrochloride salt form of MK-8718 which has been found to be a HIV protease inhibitor and could be studied in HIV research. Synonyms: MK-8718 HCl; MK 8718 HCl; MK8718 HCl. Grades: 98%. CAS No. 1582732-29-3. Molecular formula: C30H31Cl2F6N5O4. Mole weight: 710.54. | |
| MK-8722 | MK-8722 is a potent pan-AMPK activator that improves glucose homeostasis but induces cardiac hypertrophy. AMPK has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. Synonyms: MK 8722; MK8722. CAS No. 1394371-71-1. Molecular formula: C24H20ClN3O4. Mole weight: 449.9. | |
| MK-8722 | MK-8722 is a potent pan-AMPK activator. MK-8722 improves glucose homeostasis but induces cardiac hypertrophy. In rodents and rhesus monkeys, MK-8722-mediated AMPK activation in skeletal muscle induced robust, durable, insulin-independent glucose uptake and glycogen synthesis, with resultant improvements in glycemia and no evidence of hypoglycemia. These effects translated across species, including diabetic rhesus monkeys, but manifested with concomitant cardiac hypertrophy and increased cardiac glycogen without apparent functional sequelae. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MK-8722; MK 8722; MK8722. Product Category: Activators. Appearance: Solid powder. CAS No. 1394371-71-1. Molecular formula: C24H20ClN3O4. Mole weight: 449.89. Purity: >98%. IUPACName: (3R,3aR,6R,6aR)-6-((6-([1,1'-biphenyl]-4-yl)-7-chloro-3H-imidazo[4,5-b]pyridin-2-yl)oxy)hexahydrofuro[3,2-b]furan-3-ol. Canonical SMILES: ClC1=C2C(NC(O[C@@H]3CO[C@@]4([H])[C@]3([H])OC[C@H]4O)=N2)=NC=C1C5=CC=C(C6=CC=CC=C6)C=C5. Product ID: ACM1394371711. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MK-8745 | MK-8745 is a novel Aurora-A specific inhibitor. MK8745 induced apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. Exposure of p53 wild-type cells to MK8745 resulted in the induction of p53 phosphorylation (ser15) and an increase in p53 protein expression. p53-dependent apoptosis by MK8745 was further confirmed in HCT 116 p53(-/-) cells transfected with wild-type p53. Synonyms: MK-8745; MK 8745; MK8745. Grades: 0.98. CAS No. 885325-71-3. Molecular formula: C20H19ClFN5OS. Mole weight: 431.91416. | |
| MK 886 | MK 886. Group: Biochemicals. Grades: Purified. CAS No. 118414-82-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MK-886 | MK-886 (L 663536) is a potent, cell-permeable and orally active FLAP ( IC 50 of 30 nM) and leukotriene biosynthesis ( IC 50 s of 3 nM and 1.1 μM in intact leukocytes and human whole blood, respectively) inhibitor. MK-886 is also a non-competitive PPARα antagonist and can induce apoptosis [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L 663536. CAS No. 118414-82-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14166. | |
| MK-886 | This active molecular is a leukotriene antagonist with the IC50 of 3 nM in human polymorphonuclear leukocytes. MK-886 also inhibits PPARα activation. Inhibition of 5-lipoxygenase-activating protein (FLAP) leads to inhibited 5-lipoxygenase (5-LOX), and this may help in treating atherosclerosis. MK-886 and Celecoxib have an inhibitory effect on the growth of pancreatic cancer cell line SW1990 and angiogenesis. In Mar 1996, an animal study had been added to the Ischaemic Heart Disease pharmacodynamics section. Uses: Ischaemic heart disease. Synonyms: MK-886; MK886; MK 886; L-663,536; L663,536; L 663,536; L-663536; L663536; L 663536; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoic acid,L-663,536,118427-55-7( MK-886 Sodium Salt). Grades: 98%. CAS No. 118414-82-7. Molecular formula: C27H34ClNO2S. Mole weight: 472.08. | |
| MK-886 (3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt) | Binds to 5-lipoxygenase-activating protein with high affinity and prevents the activation of 5-lipoxygenase, thus inhibiting the biosynthesis of leukotrienes. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic Acid, Sodium Salt. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MK-886 sodium salt | MK-886 is a leukotriene inhibitor that works by blocking 5-lipoxygenase activating protein (FLAP). MK886 also inhibits PPAR alpha by a non-competitive mechanism. Uses: Lipoxygenase inhibitors. Synonyms: MK-886 sodium; MK 886 sodium; MK886 sodium; 3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate sodium salt. Grades: ≥99%. CAS No. 118427-55-7. Molecular formula: C27H33ClNO2S·Na. Mole weight: 494.1. | |
| MK-886 sodium salt | MK-886 sodium salt. Group: Biochemicals. Alternative Names: 3-[tert-Butylthio-1-(4-chlorobenzyl)-5-isopropyl-1H-indol-2-yl]-2,2-dimethylpropionic acid, sodium salt. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C27H33ClNNaO2S. US Biological Life Sciences. | Worldwide |
| MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886) | MK 886 Sodium Salt (3-(1-(4-chlorobenzyl)-3-t-butylthio-5-isopropylindol-2-yl)-2,2-dimethylpropanoic acid, L 663536, L-663536, MK-886). Group: Biochemicals. Alternative Names: Sodium;3-[3-tert-butylsulfanyl-1-[(4-chlorophenyl)methyl]-5-propan-2-ylindol-2-yl]-2,2-dimethylpropanoate. Grades: Highly Purified. CAS No. 118427-55-7. Pack Sizes: 25mg. Molecular Formula: C27 H33 ClNO 2 , Molecular Weight: 494.1. US Biological Life Sciences. | Worldwide |
| MK-912 hydrochloride | MK-912 is a potent new selective alpha 2-adrenergic receptor antagonist that is originated by Merck & Co for the treatment of Major depressive disorder. In Dec 1999, Phase-II clinical trials for Depression in USA was on going, but now it is discontinued. Uses: Major depressive disorder. Synonyms: MK912; MK 912; MK-912. 1',3'-dimethylspiro[1,3,4,6,7,12b-hexahydro-[1]benzofuro[2,3-a]quinolizine-2,4'-1,3-diazinane]-2'-one;hydrochloride. Grades: 98%. CAS No. 119942-70-0. Molecular formula: C20H26ClN3O2. Mole weight: 375.90. | |
| MK940 | MK940 is a potential central nervous system agent. It is used as an anti-depressant. Uses: Mk940 is used as an anti-depressant. Synonyms: MK-940; MK 940; 5-[3-(Methylamino)propyl]-10,11-dihydro-5H-5,10-epoxydibenzo[a,d][7]annulen-11-ol; trans-10,11-Dihydro-5,10-epoxy-5-(3-(methylamino)propyl)-5H-dibenzo(a,d)cyclohepten-11-ol hydrogen maleate. Grades: 98%. CAS No. 5154-92-7. Molecular formula: C19H21NO2. Mole weight: 295.38. | |
| MK 996 | MK-996, an imidazopyridine derivative, has been found to be an angiotensin receptor antagonist that was once developed in the treatment of hypertension by Merck. Synonyms: MK996; MK 996; MK-996; L-159282; L 159282; L159282. CHEMBL293511; 3-((2'-(Benzoylaminosulfonyl)biphenyl-4-yl)methyl)-2-ethyl-5,7-dimethyl-3H-imidazo(4,5-b)pyridine; 3-((2'-(BENZOYLAMINOSULFONYL)BIPHENYL-4-YL)METHYL)-2-ETHYL-5,7-DIMETHYL-3H-IMIDAZO[4,5-B]PYRIDINE. Grades: 98%. CAS No. 157263-00-8. Molecular formula: C30H28N4O3S. Mole weight: 524.64. | |
| MK-B 251 | MK-B 251 is a synthetic bio-active chemical. Uses: A synthetic bio-active chemical. Synonyms: MKB251; MKB 251; MK-B251; MK B 251;MKB-251; MK-B-251; MK-B 251; 2-[4-(1,1,2,2-tetrafluoro-2-phenylethyl)phenyl]propan-2-amine;hydrochloride. Grades: ≥98%. CAS No. 40396-69-8. Molecular formula: C17H18ClF4N. Mole weight: 347.78. | |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. In addition, this agent has been shown to inhibit the activities of the oncogenic kinase Akt, the mTOR pathway, and importin-beta, a protein essential to the transport of other proteins from the cytosol into the nucleus. Synonyms: MKC1; MKC 1; R 440; Ro 317453; Ro-317453; Ro317453; 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. | |
| MKC-1 | MKC-1 (Ro-31-7453) is an orally active and potent cell cycle inhibitor with broad antitumor activity. MKC-1 inhibits the Akt/mTOR pathway. MKC-1 arrests cellular mitosis and induces cell apoptosis by binding to a number of different cellular proteins including tubulin and members of the importin β family [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ro-31-7453. CAS No. 125313-92-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13691. | |
| MKC-1 | MKC-1 is an orally bioavailable, small-molecule, bisindolylmaleimide cell cycle inhibitor with potential antineoplastic activity. MKC-1 and its metabolites inhibit tubulin polymerization, blocking the formation of the mitotic spindle, which may result in cell cycle arrest at the G2/M phase and apoptosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC1; MKC 1; MKC-1; R 440; R-440; R440; Ro 317453; Ro-317453; Ro317453. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 125313-92-0. Molecular formula: C22H16N4O4. Mole weight: 400.39. Purity: >98%. IUPACName: 3-(1-methyl-1H-indol-3-yl)-4-(1-methyl-6-nitro-1H-indol-3-yl)-1H-pyrrole-2,5-dione. Canonical SMILES: O=C(C(C1=CN(C)C2=C1C=CC=C2)=C3C4=CN(C)C5=C4C=CC([N+]([O-])=O)=C5)NC3=O. Product ID: ACM125313920. Alfa Chemistry ISO 9001:2015 Certified. Categories: Mk 153 Shoulder-Launched Multipurpose Assault Weapon. | |
| MKC-3946 | MKC3946 is a potent and soluble IRE1α inhibitor. MKC-3946 blocks XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC-3946; MKC 3946; MKC3946. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1093119-54-0. Molecular formula: C21H20N2O3S. Mole weight: 380.46. Purity: >98%. IUPACName: 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde. Canonical SMILES: O=CC1=C(C=CC2=C1C=CC(C3=CC=C(S3)C(N4CCN(CC4)C)=O)=C2)O. Product ID: ACM1093119540. Alfa Chemistry ISO 9001:2015 Certified. | |
| MKC-3946 | MKC-3946 is a potent inhibitor of inositol-requiring enzyme 1α (IRE1α). It inhibits XBP1 mRNA splicing and exhibits cytotoxicity against AML cells. MKC-3946 leads to modest growth inhibition in MM cells but has no effect on normal mononuclear cells in vitro. Synonyms: MKC-3946; MKC 3946; MKC3946; 2-hydroxy-6-(5-(4-methylpiperazine-1-carbonyl)thiophen-2-yl)-1-naphthaldehyde. Grades: >98%. CAS No. 1093119-54-0. Molecular formula: C21H20N2O3S. Mole weight: 380.462. | |
| MKC8866 | MKC8866 Inhibitor. Uses: Scientific use. Product Category: T15594. CAS No. 1338934-59-0. |  |
| MKC-8866 | MKC-8866, also known as IRE1-IN-8866, is an inhibitor of IRE1 RNase activity. MKC8866 strongly inhibits prostate cancer (PCa) tumor growth as monotherapy in multiple preclinical models in mice and shows synergistic antitumor effects with current PCa drugs. Interestingly, global transcriptomic analysis reveal that IRE1α-XBP1s pathway activity is required for c-MYC signaling, one of the most highly activated oncogenic pathways in PCa. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MKC-8866; MKC 8866; MKC8866; IRE1-IN-8866; IRE1IN8866; IRE1 IN 8866; IRE1-IN8866; IRE1-IN 8866; IRE1IN-8866; IRE1IN 8866. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1338934-59-0. Molecular formula: C18H19NO7. Mole weight: 361.35. Purity: >98%. IUPACName: 7-Hydroxy-6-methoxy-4-methyl-3-(2-morpholino-2-oxoethyl)-2-oxo-2H-chromene-8-carbaldehyde. Canonical SMILES: O=CC1=C(O)C(OC)=CC2=C1OC(C(CC(N3CCOCC3)=O)=C2C)=O. Product ID: ACM1338934590. Alfa Chemistry ISO 9001:2015 Certified. | |
| MKI-833 | MKI 833 is a small molecule inhibitor of the MEK/MAPK pathway. Synonyms: Balamapimod; MKI 833; MKI833; 3-Quinolinecarbonitrile, 4-[[3-chloro-4-[(1-methyl-1H-imidazol-2-yl)thio]phenyl]amino]-6-methoxy-7-[4-(1-pyrrolidinyl)-1-piperidinyl]-. CAS No. 863029-99-6. Molecular formula: C30H32ClN7OS. Mole weight: 574.14. | |
| MKT 077 | MKT-077 is a cationic rhodacyanine dye. It shows antiproliferative activity against cancer cell lines with EC50s value of 1.4-2.2 μM in vitro through its ability to inhibit members of the heat shock protein 70 family of molecular chaperones. Synonyms: MKT-077; MKT 077; MKT077; FJ-776; FJ 776; FJ776; 1-Ethyl-2-[[3-ethyl-5-(3-methyl-2(3H)-benzothiazolylidene)-4-oxo-2-thiazolidinylidene]methyl]-pyridinium chloride. Grades: ≥98% by HPLC. CAS No. 147366-41-4. Molecular formula: C21H22ClN3OS2. Mole weight: 432. | |
| MKT 077 | MKT-077 is used in the treatment of Alzheimers diseases and other tauopathies. Also, is a rhodacyanine derivative that selectively targets cancer cells and overcomes tamoxifen resistance. Binds mot-2; selectively cytotoxic in cancer cells.Biological Activity:Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. Group: Biochemicals. Alternative Names: 1-Ethyl-2- [ [3-ethyl-5- (3-methyl-2 (3H) -benzothiazolylidene) -4-oxo-2-thiazolidinylidene] methyl] -pyridinium Chloride; FJ 776. Grades: Highly Purified. CAS No. 147366-41-4. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C??H??N?OS??; Ci, Molecular Weight: 441.01. US Biological Life Sciences. | Worldwide |
| ML00253764 | ML00253764 is a selective melanocortin receptor 4 ( MC4R ) antagonist, can induce apoptosis by inhibiting ERK1/2 and Akt phosphorylation, and has anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 681847-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124740. | |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML 00253764 hydrochloride | ML 00253764 hydrochloride is a MC4 receptor antagonist with IC50 value of 320nM. It may be used to counteract the effects of cachexia in cancer patients. Synonyms: ML 00253764 hydrochloride; ML00253764 hydrochloride; ML-00253764 hydrochloride; 2-[2-[2-(5-Bromo-2-methoxyphenyl)ethyl]-3-fluorophenyl]-4,5-dihydro-2-1H-imidazole hydrochloride. Grades: ≥98% by HPLC. CAS No. 1706524-94-8. Molecular formula: C18H18BrFN2O.HCl. Mole weight: 413.71. | |
| ML-030 | ML-030, a triazolothiadiazine, is a potent PDE4 inhibitor in a cell-based cyclic nucleotide-gated cation channel biosensor assay (EC50 = 18.7 nM), with IC50 of 6.7 nM, 12.9 nM, 48.2 nM, 37.2 nM, 452 nM and 49.2 nM for PDE4A, PDE4A1, PDE4B1, PDE4B2, PDE4C1,and PDE4D2, respectively. Synonyms: ML-030; ML 030; ML030; CID-11757146; CID 11757146; CID11757146. 3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine. CAS No. 1013750-77-0. Molecular formula: C20H20N4O4S. Mole weight: 412.46. | |
| ML-031 | ML-031 is a S1P2 agonist with EC50 value of 1 μM in a S1P reporter assay. Synonyms: ML 031; ML031; CID-2113511; 1-[2-(1-benzyl-2,5-dimethylpyrrol-3-yl)-2-oxoethyl]pyrrolidine-2,5-dione. Grades: ≥95%. CAS No. 852230-33-2. Molecular formula: C19H20N2O3. Mole weight: 324.4. | |
| ML095 | ML095 is a biochemical inhibitor of PLAP. ML095 is useful to elucidate the key biological functions and natural substrates of human PLAP [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CID-25067483. CAS No. 1135318-57-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-128000. | |
| ML-095 hydrochloride | ML-095 is an inhibitor of placental alkaline phosphatase (PLAP) with IC50 value of 3.7 μM. Synonyms: ML-095 HCl; ML 095 hydrochloride; ML095 hydrochloride; CID-25067483; 1-(3,4-dihydroxyphenyl)-2-(2-ethylimidazol-1-yl)ethanone hydrochloride. Grades: ≥98%. CAS No. 1135318-57-8. Molecular formula: C13H14N2O3·HCl. Mole weight: 282.7. | |
| ML-097 | ML-097 is a pan activator of Ras-related GTPases. Synonyms: ML 097; ML097; CID-2160985; 2-[(2-bromophenyl)methoxy]benzoic acid; 2-[(2-bromobenzyl)oxy]benzoic acid. Grades: ≥95%. CAS No. 743456-83-9. Molecular formula: C14H11BrO3. Mole weight: 307.1. | |
| ML-098 | ML-098, also called as CID-7345532, is an activator of the GTP-binding protein Rab7 (EC50 = 77.6 nM) with selectivity without disrupting related GTPases cdc42, Ras, Rab-2A, and Rac1 (EC50s = 588.8, 346.7, 158.5, and 794.3 nM, respectively). Synonyms: 1-[2-(2,5-dimethylphenoxy)ethyl]indole-3-carboxylic acid; ML 098; ML098; CID-7345532; CID 7345532; CID7345532. CAS No. 878978-76-8. Molecular formula: C19H19NO3. Mole weight: 309.36. | |
| ML-099 | ML-099 is a pan activator of Ras-related GTPases. Synonyms: ML 099; ML099; CID-888706; 2-[(2-Phenylethyl)thio]nicotinic acid. Grades: ≥98%. CAS No. 496775-95-2. Molecular formula: C14H13NO2S. Mole weight: 259.3. | |
| ML-10 | ML-10 is a small molecule apoptosis probe. Due to the presence of fluorine atoms, ML-10 can be radiolabeled with 18 F isotopes and can be used for apoptosis positron emission tomography imaging studies. ML-10 is selectively taken up and accumulated in apoptotic cells, while being excluded from live or necrotic cells. In addition, the uptake of ML-10 is associated with apoptotic features such as caspase activation, Annexin-V binding, and disruption of mitochondrial membrane potential [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1216897-16-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-76573. | |
| ML 10302 | ML 10302 is a potent agonist 5-HT4 receptor with K i of 1.07 nM. 5-Hydroxytryptamine (5-HT4) receptor agonists stimulate gut motility through cholinergic pathways. ML10302 induces significant prokinesia both in the small bowel and colon through activation of cholinergic pathways. ML 10302 also has the potential for the research of neurology diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 148868-55-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14441. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride is a 5-HT4 agonist with EC50 value of 4 nM. It can increase sAPPα levels in the cortex in an animal model of Alzheimer's disease and exhibit progastrokinetic effects in vivo. Synonyms: ML-10302 HCl; ML-10302; ML 10302; ML10302. 4-Amino-5-chloro-2-methoxybenzoic acid 2-(1-piperidinyl)ethyl ester hydrochloride. Grades: ≥99% by HPLC. CAS No. 186826-17-5. Molecular formula: C15H21ClN2O3.HCl. Mole weight: 349.25. | |
| ML 10302 hydrochloride | ML 10302 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 186826-17-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML115 | ML115 is a molecular probe of the signal transducer and activator of transcription ( STAT3 ). ML115 is a STAT3 agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 912798-42-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-111152. | |
| ML-115 | ML-115 is a potent, cell-permeable STAT3 activator with EC50 value of 2 nM. It is inactive against the related STAT1 and NFκB anti-targets. ML-115 exhibits no cytotoxicity in the parental cell lines in the STAT3 assay (HT-1080) and STAT1 assay (NIH-3T3). Synonyms: ML115; ML 115; 3-Isoxazolecarboxamide, N-(4-chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-; N-(4-Chloro-2,5-dimethoxyphenyl)-5-cyclopropyl-3-isoxazolecarboxamide. Grades: ≥98%. CAS No. 912798-42-6. Molecular formula: C15H15ClN2O4. Mole weight: 322.74. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride is an ATP-competitive IKK2-selective inhibitor with IC50 value of 60 nM at 50 μM ATP. It can inhibit paw swelling, bone and cartilage degradation. Synonyms: ML 120B dihydrochloride; ML120B dihydrochloride; ML-120B dihydrochlorideN-(6-Chloro-7-methoxy-9H-pyrido[3,4-b]indol-8-yl)-2-methyl-3-pyridinecarboxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1782573-78-7. Molecular formula: C19H15ClN4O2.2HCl. Mole weight: 439.72. | |
| ML 120B dihydrochloride | ML 120B dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML130 | ML130 (Nodinitib-1) is a potent and selective inhibitor of NOD1 with IC50 of 0.56 μM, inhibits NF-κB activation, exhibits 36-fold selectivity over NOD2. Synonyms: ML 130; ML-130; Nodinitib-1; Noditinib-1; 1-Tosyl-1H-benzo[d]imidazol-2-amine. Grades: >98%. CAS No. 799264-47-4. Molecular formula: C14H13N3O2S. Mole weight: 287.34. | |
| ML 130 | ML 130. Group: Biochemicals. Grades: Purified. CAS No. 799264-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-132 | ML132, also known as CID-4462093 or NCGC-00183434, is the most potent caspase 1 inhibitor reported to date. It also possesses a unique selectivity pattern relative to other reported caspase inhibitors. Synonyms: NCGC 00185682; ML132; ML 132; N-(4-Amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-L-prolinamide; L-Prolinamide, N-(4-amino-3-chlorobenzoyl)-3-methyl-L-valyl-N-[(1S)-2-carboxy-1-cyanoethyl]-. Grades: ≥98%. CAS No. 1230628-71-3. Molecular formula: C22H28ClN5O5. Mole weight: 477.94. | |
| ML133 HCl | ML133 HCl is a selective potassium channel inhibitor for Kir2.1 with IC50 of 1.8 μM (pH 7.4) and 290 nM (pH 8.5), has no effect on Kir1.1 and weak activity for Kir4.1 and Kir7.1. Synonyms: ML133 hydrochloride; (4-Methoxybenzyl)(1-naphthylmethyl)amine Hydrochloride; N-(4-methoxybenzyl)-1-(naphthalen-1-yl)methanamine hydrochloride. Grades: >98%. CAS No. 1222781-70-5. Molecular formula: C19H19NO.HCl. Mole weight: 313.82. | |
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