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| Product | Description | |
|---|---|---|
| ML318 | ML318 is a novel inhibitor of Pseudomonas aeruginosa PvdQ acylase, an enzyme involved in siderophore pyoverdine synthesis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1610516-67-0. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H8F4N2, Molecular Weight: 280.22. US Biological Life Sciences. |  Worldwide |
| ML318 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| ML323 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML-323 | ML323 is a reversible and potent USP1-UAF1 inhibitor with IC50 vallue of 76 nM in a Ub-Rho assay and 174 nM and 820 nM in orthogonal gel-based assays using K63-linked diubiquitin (di-Ub) and monoubiquitinated PCNA (Ub-PCNA) as substrates, respectively. Synonyms: ML-323; ML 323; ML323. CAS No. 1572414-83-5. Molecular formula: C23H24N6. Mole weight: 384.487. |  |
| ML-323 | ML-323 is a reversible, potent USP1-UAF1 inhibitor with IC50 of 76 nM in a Ub-Rho assay. The measured inhibition constants of ML-323 for the free enzyme (Ki) is 68 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1572414-83-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17543. |  |
| ML324 | ML324 exhibits good Caco-2 cell permeability, and possesses excellent microsomal stability in the presence of both mouse and rat liver microsomes. Synonyms: ML-324; ML 324; ML324; CID-44143209; CID 44143209; CID44143209. Grades: >98%. CAS No. 1222800-79-4. Molecular formula: C21H23N3O2. Mole weight: 349.43. | |
| ML324 | ML324 is a potent JMJD2 demethylase inhibitor with antiviral activity. ML324 also exhibits inhibition for the histone demethylase KDM4B, with an IC50 of 4.9 ?M. ML324 has potent anti-viral activity against both herpes simplex virus (HSV) and human cytomegalovirus (hCMV) infection via inhibition viral IE gene expression[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1222800-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12725. | |
| ML324 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 324 dihydrochloride | ML 324 dihydrochloride is an inhibitor of Jumonji domain-containing protein 2 (JMJD2) histone demethylase. It potently suppresses herpes simplex virus (HSV) IE gene expression and viral reactivation from latency. Synonyms: ML 324 dihydrochloride; ML324 dihydrochloride; ML-324 dihydrochloride; N-[3-(dimethylamino)propyl]-4-(8-hydroxy-6-quinolinyl)-benzamide dihydrochloride. Grades: 99%. Molecular formula: C21H23N3O2.2HCl. Mole weight: 422.35. | |
| ML329 | ML329 is a small molecule MITF inhibitor that inhibits the expression of numerous micropthalmia-associated transcription factor (MITF) target genes and blocks the proliferation of numerous cell lines that require MITF for proliferation. ML329 inhibits TRPM-1 promoter activity (IC50 = 1.2 μM). Synonyms: 4-[(1,4-dioxonaphthalen-2-yl)amino]benzenesulfonamide; ML329; ML 329; ML-329. CAS No. 19992-50-8. Molecular formula: C16H12N2O4S. Mole weight: 328.34. | |
| ML329 | ML329 is a micropthalmia-associated transcription factor (MITF) inhibitor, which inhibits TRPM-1 promoter activity with an IC50 of 1.2 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 19992-50-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101464. | |
| ML334 | ML334 is a potent, cell permeable activator of NRF2 by inhibition of Keap1-NRF2 protein-protein interaction. ML334 binds to Keap1 Kelch domain with a Kd of 1 ?M. ML334 stimulates NRF2 expression and nuclear translocation and induces antioxidant response elements (ARE) activity[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LH601A. CAS No. 1432500-66-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110258. | |
| ML 334 | ML 334 is an inhibitor of Keap1-Nrf2 interaction. It can affect the cytoprotective responses to oxidative and electrophilic stress. Synonyms: ML 334; ML334; ML-334; (1S, 2R) -2- [ [ (1S) -1- [ (1, 3-Dihydro-1, 3-dioxo-2H-isoindol-2-yl) methyl] -3, 4-dihydro-2 (1H) -isoquinolinyl] carbonyl] cyclohexanecarboxylic acid. Grades: ≥98% by HPLC. CAS No. 1432500-66-7. Molecular formula: C26H26N2O5. Mole weight: 446.5. | |
| ML-335 | ML-335 is a potent and selective TREK-1/2 activator with EC50 values of 14.3 μM and 5.2 μM, respectively. Synonyms: ML 335; ML335; N-[(2,4-Dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]benzamide. Grades: ≥98% by HPLC. CAS No. 825658-06-8. Molecular formula: C15H14Cl2N2O3S. Mole weight: 373.25. | |
| ML336 | ML336 is quinazolinone-based inhibitor against venezuelan equine encephalitis virus (VEEV), with IC50s of 32, 20, and 42 nM for VEEV TC-83 CPE , VEEV V3526 CPE, VEEV Wild Type CPE, respectively. ML336 potently inhibits a VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and wild type Trinidad donkey) in the low nanomolar range[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613465-33-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-12928. | |
| ML-336 | ML-336 is a quinazolinone-based inhibitor of Venezuelan Equine Encephalitis Virus (VEEV). It inhibits VEEV-induced cytopathic effect in three strains of the virus (TC-83, V3526, and Trinidad donkey). Synonyms: ML 336; ML336; (E)-2-((1,4-dimethylpiperazin-2-ylidene)-amino)-5-nitro-n-phenylbenzamide. Grades: ≥95%. CAS No. 1613465-33-0. Molecular formula: C19H21N5O3. Mole weight: 367.4. | |
| ML337 | ML337 is a Selective negative allosteric modulator of mGlu3 with IC50 value of 593 nM. It shows no activity at mGlu1, mGlu2 or mGlu4-8 at concentrations up to 30 μM. ML337 is a best-in-class probe for studying non-competitive antagonism of mGlu3. Uses: In vitro and in vivo probe for studying non-competitive antagonism of mglu3. Synonyms: CHEMBL2385886; ML337; ML 337; ML-337; MLS004580699; GTPL8765;(R)-(2-fluoro-4-((4-methoxyphenyl)ethynyl)phenyl)(3-hydroxypiperidin-1-yl)methanone. Grades: 98%. CAS No. 1443118-44-2. Molecular formula: C21H20FNO3. Mole weight: 353.39. | |
| ML 337 | ML 337. Group: Biochemicals. Grades: Purified. CAS No. 1443118-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML338 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML339 | ML339 is a potent and selective CXCR6 antagonist (IC50 = 140 nM) that is selective (IC50 >79 μM) against CXCR5, CXCR4, CCR6 and Apelin receptor (APJ). It has the potential to advance the field of prostate cancer research. Synonyms: N-[(1R,5S)-9-{2-[(2-Chlorophenyl)amino]-2-oxoethyl}-9-azabicyclo[3.3.1]non-3-yl]-3,4,5-trimethoxybenzamide; 9-Azabicyclo[3.3.1]nonane-9-acetamide, N-(2-chlorophenyl)-3-[(3,4,5-trimethoxybenzoyl)amino]-, (3-exo)-. Grades: ≥95%. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.00. | |
| ML339 | ML339 is a selective CXCR6 antagonist with an IC50 of 140 nM. ML339 antagonizes ?-arrestin recruitment and cAMP signaling pathway of human CXCR6 receptor induced by CXCL16, with IC50 of 0.3 ?M and 1.4 ?M, respectively. ML339 shows weaker activity against the recruitment of ?-arrestin in mouse CXCR6 receptors, with an IC50 of 18 ?M. ML339 has no inhibitory effect on CXCR5?CXCR4?CXCR6 and apelin receptor (APJ), with IC50 >79 ?M. ML339 has the potential to promote the development of prostate cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2579689-83-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122197. | |
| ML-339 | ML-339 is a potent and selective hCXCR6 antagonist (IC50 = 140 nM). Uses: Designed for use in research and industrial production. Additional or Alternative Names: ML-339; ML 339; ML339. Product Category: Antagonists. Appearance: Solid powder. CAS No. 2579689-83-9. Molecular formula: C26H32ClN3O5. Mole weight: 502.01. Purity: >98%. IUPACName: N-((1R,3s,5S)-9-(2-((2-chlorophenyl)amino)-2-oxoethyl)-9-azabicyclo[3.3.1]nonan-3-yl)-3,4,5-trimethoxybenzamide. Canonical SMILES: O=C(N[C@@H]1C[C@H](N2CC(NC3=CC=CC=C3Cl)=O)CCC[C@H]2C1)C4=CC(OC)=C(OC)C(OC)=C4. Product ID: ACM2579689839. Alfa Chemistry ISO 9001:2015 Certified. Categories: MD 339. |  |
| ML3403 | ML 3403 is a potent and selective p38 mitogen-activated protein kinase (MAPK) inhibitor. MAPK is a key mediator in cytokine-induced signaling events and plays an integral role in disease states including oncogenesis, autoimmune diseases, and inflammatory processes. Therefore, MAPK inhibitors such as ML 3403 provides an attractive strategy for therapeutic intervention. Synonyms: ML 3403; ML-3403; p38 MAP Kinase Inhibitor III; 4-(4-(4-fluorophenyl)-2-(methylthio)-1H-imidazol-5-yl)-N-(1-phenylethyl)pyridin-2-amine. Grades: 98%. CAS No. 549505-65-9. Molecular formula: C23H21FN4S. Mole weight: 404.51. | |
| ML 3403 | ML 3403. Group: Biochemicals. Grades: Purified. CAS No. 549505-65-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML-345 | ML-345 is a small-molecule inhibitor of insulin-degrading enzyme (IDE) that selectively targets Cys819 in IDE. ML-345 is potentially utilized as a pharmacophore for drug development in diabetes and Alzheimer's disease research. Synonyms: ML 345; ML345; 5-Fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one. Grades: ≥95%. CAS No. 1632125-79-1. Molecular formula: C21H22FN3O5S2. Mole weight: 479.5. | |
| ML346 | ML346, a barbituric acid skeleton compound, is a novel activator of Hsp70 which could induce HSF-1-dependent chaperone expression and repair protein folding in both cellular and animal models. It has no obvious cytotoxicity and shows some extent of specif. Uses: Ml346 is a novel activator of hsp70 which could induce hsf-1-dependent chaperone expression and repair protein folding in both cellular and animal models. Synonyms: ML346; ML-346; ML 346; ZINC00244844; AC1LG9A8; Ambcb5772104; MLS004711999; SCHEMBL13317556. Grades: 95%. CAS No. 100872-83-1. Molecular formula: C14H12N2O4. Mole weight: 272.26. | |
| ML346 | ML346 is an activator of Hsp70 expression and HSF-1 activity, with an EC50 of 4.6 ?M for Hsp70. ML346 restores protein folding in conformational disease models, without significant cytotoxicity or lack of specificity. ML346 induces specific increases in genes and protein effectors of the heat shock response (HSR), including chaperones such as Hsp70, Hsp40, and Hsp27[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 100872-83-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-18669. | |
| ML347 | ML347 (LDN193719) is a highly selective ALK1/ALK2 inhibitor. ML347 has IC50 values of 46 and 32 nM against ALK1 and ALK2, respectively, >300-fold selective over ALK3. ML347 block the phosphorylation of Smad1/5 by TGF-?1[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDN 193719. CAS No. 1062368-49-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12274. | |
| ML347 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML347 | ML347 is a selective BMP receptor inhibitor with IC50 value of 32 nM for ALK2, >300-fold selectivity over ALK3. It also inhibits ALK1 activity with IC50 value of 46 nM. Synonyms: ML-347; 5-[6-(4-methoxyphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline. Grades: >98%. CAS No. 1062368-49-3. Molecular formula: C22H16N4O. Mole weight: 352.39. | |
| ML 347 | ML 347. Group: Biochemicals. Grades: Purified. CAS No. 1062368-49-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML348 | ML348, also known as CID 3238952 or SID 160654487, is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM). It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000). Synonyms: N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide; ML348; ML-348; ML 348; CID 3238952; SID 160654487. CAS No. 899713-86-1. Molecular formula: C18H17ClF3N3O3. Mole weight: 415.79. | |
| ML348 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML348 | ML348 (GNF-Pf-1127) is a selective and reversible acyl-protein thioesterase 1 (APT1)/lysophospholipase 1 (LYPLA1) inhibitor with an IC50 of 210 nM, and barely inhibits LYPLA2[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GNF-Pf-1127. CAS No. 899713-86-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100736. | |
| ML 348 | ML 348. Group: Biochemicals. Grades: Purified. CAS No. 899713-86-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML349 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML349 | ML349 is a potent and specific acyl protein thioesterase 2(APT2)/lysophospholipase 2 (LYPLA2) inhibitor with a Ki of 120 nM. ML349 is also an inhibitor of LYPLA2 with an IC50 of 144 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 890819-86-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100737. | |
| ML 349 | ML 349 is a lysophospholipase 2 inhibitor with IC50 value of 144 nM. Synonyms: ML349; ML-349; ML 349. (5,5-Dioxido-4H-thieno[3,2-c][1]benzothiopyran-2-yl)[4-(4-methoxyphenyl)-1-piperazinyl]methanone. Grades: ≥98% by HPLC. CAS No. 890819-86-0. Molecular formula: C23H22N2O4S2. Mole weight: 454.56. | |
| ML 349 | ML 349. Group: Biochemicals. Grades: Purified. CAS No. 890819-86-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML351 | ML351 is a potent and highly specific 15-LOX-1 inhibitor with an IC 50 of 200 nM. ML351 shows excellent selectivity (>250-fold) versus the related isozymes, 5-LOX, platelet 12-LOX, 15-LOX-2, ovine COX-1, and human COX-2 [1]. ML351 prevents dysglycemia and reduces β-cell oxidative stress in nonobese diabetic mouse model of T1D [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 847163-28-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111310. | |
| ML351 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 351 | ML 351 is a potent and selective inhibitor of 12/15-lipoxygenase (IC50 value 200 nM against human 12/15-LOX), which catalyzes the oxidation of polyunsaturated fatty acids to produce unsaturated fatty acid hydroperoxides. Studies indicate that ML351 is protective against oxidative glutamate toxicity in mouse neuronal HT22 cells, and reduces infarct size following permanent focal ischemia in a mouse model of ischemic stroke. Synonyms: ML 351; ML-351; ML351; CID 664510; CID664510; CID-664510; 5-(methylamino)-2-naphthalen-1-yl-1,3-oxazole-4-carbonitrile. Grades: 98%. CAS No. 847163-28-4. Molecular formula: C15H11N3O. Mole weight: 249.27. | |
| ML352 | ML352 is a potent and non-competitive inhibitor of the presynaptic choline transporter (CHT; Ki value 92 nM). Synonyms: ML352; ML-352; ML 352; VU0476201; VU-0476201; VU 0476201; VU0476328; VU-0476328; VU 0476328; N-((3-Isopropylisoxazol-5-yl)methyl)-4-methoxy-3-((1-methylpiperidin-4-yl)oxy)benzamide; 4-methoxy-3-(1-methylpiperidin-4-yl)oxy-N-[(3-propan-2-yl-1,2-oxazol-5-yl)methyl]benzamide. Grades: 98%. CAS No. 1649450-12-3. Molecular formula: C21H29N3O4. Mole weight: 387.47. | |
| ML 352 hydrochloride | ML 352 hydrochloride is a selective presynaptic choline transporter inhibitor. Synonyms: ML 352 hydrochloride; ML352 hydrochloride; ML-352 hydrochloride; 4-Methoxy-N-[[3-(1-methylethyl)-5-isoxazolyl]methyl]-3-[(1-methyl-4-piperidinyl)oxy]benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1962928-20-6. Molecular formula: C21H29N3O4.HCl. Mole weight: 423.93. | |
| ML354 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML 354 | ML 354 is a selective PAR4 antagonist with IC50 value of 140 nM. Synonyms: ML354; ML-354; ML 354; VU0099704; VU-0099704; VU 0099704; 1-Methyl-5-nitro-3-phenyl-1H-indole-2-methanol. Grades: ≥98% by HPLC. CAS No. 89159-60-4. Molecular formula: C16H14N2O3. Mole weight: 282.29. | |
| ML 354 | ML 354. Group: Biochemicals. Grades: Purified. CAS No. 89159-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| ML355 | ML355 inhibits PAR-4 induced aggregation and calcium mobilization in human platelets and reduce 12-HETE in β-cells. Synonyms: ML 355; ML-355. Grades: >98%. CAS No. 1532593-30-8. Molecular formula: C21H19N3O4S2. Mole weight: 441.52. | |
| ML355 | ML355 is a potent and selective inhibitor of 12-Lipoxygenase (12-LOX) with an IC50 of 0.34 ?M, shows excellent selectivity over related lipoxygenases and cyclooxygenases, and possesses favorable ADME properties. Uses: Scientific research. Group: Signaling pathways. CAS No. 1532593-30-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12341. | |
| ML-356 | ML-356 is a potent and selective inhibitor of the thioesterase domain of fatty acid synthase (FASN-TE). It blocks the biosynthesis of palmitate, the end product of FASN. Synonyms: ML 356; ML356; 2-Ethyl-N-[4-(4-morpholin-4-ylsulfonylphenyl)-1,3-thiazol-2-yl]butanamide. Grades: ≥98%. CAS No. 1808260-45-8. Molecular formula: C19H25N3O4S2. Mole weight: 423.5. | |
| ML364 | ML364 is a selective ubiquitin specific peptidase 2 (USP2) inhibitor (IC50=1.1 ?M) with anti-proliferative activity, which direct binds to USP2 (Kd=5.2 ?M), induces an increase in cellular cyclin D1 degradation and causes cell cycle arrest. ML364 increases the levels of mitochondrial ROS and decreases in the intracellular content of ATP[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1991986-30-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-100900. | |
| ML364 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML364 | ML364 is a small molecule, reversible inhibitor of the deubiquitinase USP2, that has an IC50 value of 1.1 μM in a fluorescence-based assay using di-ubiquitin substrates. Consistent with the role of cyclin D1 in DNA damage response, ML364 also caused a decrease in homologous recombination-mediated DNA repair. Synonyms: 2-[(4-Methylphenyl)sulfonylamino]-N-(4-phenyl-1,3-thiazol-2-yl)-4-(trifluoromethyl)benzamide; ML364; ML 364; ML-364. CAS No. 1991986-30-1. Molecular formula: C24H18F3N3O3S2. Mole weight: 517.54. | |
| ML-365 | ML-365 is a potent and novel selective small molecule inhibitor of TASK1 with IC50 of 4 nM(thallium influx fluorescent assay) and 16 nM(automated electrophysiology assay). It possesses more than 60-fold selectivity for inhibition of TASK1 over TASK3. It displays little or no inhibition at 30 μM of more distantly related Kir2.1, voltage-gated potassium channel, KQT-like subfamily, member 2 (KCNQ2) and human ether-a go-go-related gene (hERG). It is a useful pharmacological probe for in vitro studies of TASK1 function. It mainly aimed at developing therapeutic intervention in further studies. Uses: Ml365 is a useful pharmacological probe for in vitro studies of task1 function. it mainly aimed at developing therapeutic intervention in further studies. Synonyms: 2-Methoxy-N-(3-(3-methylbenzamido)phenyl)benzamide; ML365; ML-365; ML 365. Grades: >98 %. CAS No. 947914-18-3. Molecular formula: C22H20N2O3. Mole weight: 360.41. | |
| ML367 | ML367 is an effective inhibitor for the stabilization of micromolar ATPase family AAA domain containing protein 5 (ATAD5), and can be used as a probe molecule with low micromolar inhibitory activity. Synonyms: NCGC00262816-01; CBMicro_009721; ChemDiv1_005670; Oprea1_377205; MLS000591778. Grades: 98%. CAS No. 381168-77-0. Molecular formula: C19H12F2N4. Mole weight: 334.3. | |
| ML 382 | ML 382 is an allosteric modulator of MrgX1 with EC50 value of 190 nM. Synonyms: ML382; ML-382; ML 382; 2-[(Cyclopropylsulfonyl)amino]-N-(2-ethoxyphenyl)benzamide. Grades: ≥98% by HPLC. CAS No. 1646499-97-9. Molecular formula: C18H20N2O4S. Mole weight: 360.43. | |
| ML385 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML385 | ML385 Inhibitor. Uses: Scientific use. Product Category: T4360. CAS No. 846557-71-9. |  |
| ML385 | ML385 is a specific nuclear factor erythroid 2-related factor 2 (NRF2) inhibitor with an IC50 of 1.9 ?M. Uses: Scientific research. Group: Signaling pathways. CAS No. 846557-71-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-100523. | |
| ML 385 | ML 385 is a novel and specific inhibitor of nuclear factor erythroid 2-related factor 2 (Nrf2; IC50 = 1.9 μM). ML 385 blocks NRF2 transcriptional activity, and enhances the efficacy of carboplatin as well as other chemotherapeutic drugs in lung cancer cells (NSCLC). Synonyms: ML-385; ML 385; ML385; 2-(1,3-benzodioxol-5-yl)-N-[5-methyl-4-[1-(2-methylbenzoyl)-2,3-dihydroindol-5-yl]-1,3-thiazol-2-yl]acetamide. CAS No. 846557-71-9. Molecular formula: C29H25N3O4S. Mole weight: 511.596. | |
| ML390 | ML-390 is an inhibitor of human DHODH, which induces differentiation in acute myeloid leukemia cell lines U937 (murine) and THP-1 (human) cell lines with an EC50 value of approximately 2 μM. Synonyms: ML390; ML 390; ML-390. Grades: 99%. CAS No. 2029049-79-2. Molecular formula: C21H21F3N2O3. Mole weight: 406.4. | |
| ML390 | ML390 is a potent dihydroorotate dehydrogenase (DHODH) inhibitor. ML390 is an inducer of myeloid differentiation and causes myeloid differentiation in murine (ER-HoxA9) and human (U937 and THP1) acute myeloid leukemia (AML) models[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2029049-79-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100688. | |
| ML396 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML398 hydrochloride | ML398 is potent dopamine 4 receptor antagonist with IC50 value of 130 nM and Ki of 36 nM. It exhibits no activity against the other dopamine receptors tested (>20 μM against D1, D2S, D2L, D3, and D5) ML398 shows >100-fold selectivity for the other dopamine receptors. Synonyms: ML398 hydrochloride; ML 398 hydrochloride; ML-398 hydrochloride; (R)-4-((1H-benzo[d]imidazol-2-yl)methyl)-2-phenethylmorpholine hydrochloride. Grades: 98%. CAS No. 1379510-21-0. Molecular formula: C20H24ClN3O. Mole weight: 357.88. | |
| ML401 | ML401 is a selective EBI2 (GPR183) receptor antagonist (IC50 of 1.03 nM). Grades: 98%. CAS No. 1597489-14-9. Molecular formula: C20H20BrClN2O. Mole weight: 419.7. | |
| ML402 | ML402, a thiophene-carboxamide, is a selective K2P2.1(TREK-1) and K2P10.1(TREK-2) activator. ML402 is inactive against K2P4.1(TRAAK)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 298684-44-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-104027. | |
| ML406 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| ML-60218 | ML-60218 is a broad-spectrum RNA pol III inhibitor, with IC50s of 32 and 27 ?M for Saccharomyces cerevisiae and human. ML-60218 disrupts already assembled viroplasms and to hamper the formation of new ones without the need for de novo transcription of cellular RNAs[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 577784-91-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122122. | |
| ML 67-33 | ML 67-33 is a K2P potassium channel activator that increases channel currents by activating core gating apparatus of channels. Synonyms: 2,7-Dichloro-9,10-dihydro-9,9-dimethyl-10-[2-(2H-tetrazol-5-yl)ethyl]acridine. Grades: 97%. CAS No. 1443290-89-8. Molecular formula: C18H17Cl2N5. Mole weight: 374.27. | |
| ML-7 | powder. Group: Fluorescence/luminescence spectroscopy. | |
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