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| Product | Description | |
|---|---|---|
| m-PEG4-DBCO | SPAAC & SPANC Click Reaction. Group: Dbco. Alternative Names: m-PEG4-NH-DBCO. CAS No. 2228857-36-9. Molecular formula: C28H34N2O6. Mole weight: 494.59. IUPACName: 4-(2-Azatricyclo[10.4.0.04,9]hexadeca-1(16),4,6,8,12,14-hexaen-10-yn-2-yl)-N-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethyl]-4-oxobutanamide. Canonical SMILES: COCCOCCOCCOCCNC (=O)CCC (=O)N1CC2=CC=CC=C2C#CC3=CC=CC=C31. Density: 1.21±0.1 g/cm3(Predicted). Catalog: CCR2228857369. |  |
| m-PEG4-NHS ester | m-PEG4-NHS ester is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Uses: Scientific research. Group: Signaling pathways. CAS No. 622405-78-1. Pack Sizes: 100 mg; 250 mg; 500 mg. Product ID: HY-124323. |  |
| mPEG5-Acrylate | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). |  |
| m-PEG5-azide | CuAAC & SPAAC Click Reactions. Group: Azides. CAS No. 1202681-04-6. Molecular formula: C11H23N3O5. Mole weight: 277.32. Catalog: CCR1202681046. | |
| mPEG5-Azide | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 5000. | |
| mPEG5K-Alkyne | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: mPEG-Alkyne, Methoxy-PEG-Alkyne. Molecular formula: average Mn 5000. | |
| mPEG5K-Hydrazide | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: Methoxy-PEG-HZ, mPEG-Hydrazide. Molecular formula: average Mn 5000. | |
| mPEG5K-Isocyanate | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: mPEG-Isocyanate. Molecular formula: average Mn 5000. | |
| mPEG5K-Phosphate | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 5000. | |
| mPEG5K-Propionaldehyde | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: mPEG-Propionaldehyde, mPEG-ALD, Methoxy-PEG-Propionaldehyde. Molecular formula: average Mn 5000. | |
| mPEG5K-Silane | Methoxy PEG silanes are used for surface modification and deactivation of glass or silica. Uses: Bioconjugation, drug delivery, peg hydrogels, crosslinkers, and surface functionalization. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: mPEG-Silane. Molecular formula: average Mn 5,000. | |
| mPEG5-NH2 | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2-[2-[2-[2- (2-methoxyethoxy) ethoxy]ethoxy]ethoxy]ethanamine. Molecular formula: 251.32g/mol. Mole weight: C11H25NO5. COCCOCCOCCOCCOCCN. InChI= 1S / C11H25NO5 / c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3 -2-12 / h2-12H2, 1H3. WGQYVGMCDPUCEJ-UHFFFAOYSA-N. | |
| mPEG5-OH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2-[2-[2-[2- (2-methoxyethoxy) ethoxy]ethoxy]ethoxy]ethanol. Molecular formula: 252.3g/mol. Mole weight: C11H24O6. COCCOCCOCCOCCOCCO. InChI= 1S / C11H24O6 / c1-13-4-5-15-8-9-17-11-10-16-7-6-14-3 -2-12 / h12H, 2-11H2, 1H3. SLNYBUIEAMRFSZ-UHFFFAOYSA-N. | |
| m-PEG5-propyne | CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction. Group: Terminal alkynes. Alternative Names: m-PEG6-propargyl. CAS No. 1101668-41-0. Molecular formula: C14H26O6. Mole weight: 290.35. IUPACName: 3-[2-[2-[2-[2- (2-Methoxyethoxy) ethoxy]ethoxy]ethoxy]ethoxy]prop-1-yne. Canonical SMILES: COCCOCCOCCOCCOCCOCC#C. Catalog: CCR1101668410. | |
| mPEG5-SH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2-[2-[2-[2- (2-methoxyethoxy) ethoxy]ethoxy]ethoxy]ethanethiol. Molecular formula: 268.37g/mol. Mole weight: C11H24O5S. COCCOCCOCCOCCOCCS. InChI= 1S / C11H24O5S / c1-12-2-3-13-4-5-14-6-7-15-8-9-16-10- 11-17 / h17H, 2-11H2, 1H3. PNMCHSOJDWEEKK-UHFFFAOYSA-N. | |
| mPEG6-Acrylate | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). | |
| mPEG6-Azide | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: imino- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethylimino] azanium. Molecular formula: average Mn 6000. Mole weight: C13H28N3O6+. COCCOCCOCCOCCOCCOCCN=[N+]=N. InChI= 1S / C13H28N3O6 / c1-17-4-5-19-8-9-21-12-13-22-11-10-20 -7-6-18-3-2-15-16-14 / h14H, 2-13H2, 1H3 / q + 1. KZFRTKCDHGYEIH-UHFFFAOYSA-N. | |
| mPEG6-NH2 | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethanamine. Molecular formula: 295.37g/mol. Mole weight: C13H29NO6. COCCOCCOCCOCCOCCOCCN. InChI= 1S / C13H29NO6 / c1-15-4-5-17-8-9-19-12-13-20-11-10-18 -7-6-16-3-2-14 / h2-14H2, 1H3. JDTWBXXBTWYNAT-UHFFFAOYSA-N. | |
| mPEG6-OH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: Methoxy-PEG6-Hydroxyl. Product ID: 2-[2-[2-[2-[2- (2-methoxyethoxy) ethoxy]ethoxy]ethoxy]ethoxy]ethanol. Molecular formula: 296.36g/mol. Mole weight: C13H28O7. [H]OCCOC. 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3. XNWFRZJHXBZDAG-UHFFFAOYSA-N. | |
| mPEG6-Propionic acid | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 3- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] propanoic acid. Molecular formula: 368.42g/mol. Mole weight: C16H32O9. COCCOCCOCCOCCOCCOCCOCCC(=O)O. InChI= 1S / C16H32O9 / c1-19-4-5-21-8-9-23-12-13-25-15-14-24 -11-10-22-7-6-20-3-2-16 (17) 18 / h2-15H2, 1H3, (H, 17, 18). NOPQIPMESCUIHH-UHFFFAOYSA-N. | |
| mPEG6-SH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethanethiol. Molecular formula: 312.42g/mol. Mole weight: C13H28O6S. COCCOCCOCCOCCOCCOCCS. InChI= 1S / C13H28O6S / c1-14-2-3-15-4-5-16-6-7-17-8-9-18-10- 11-19-12-13-20 / h20H, 2-13H2, 1H3. FCNSUDTWFXNQBG-UHFFFAOYSA-N. | |
| mPEG7-Acrylate | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). | |
| M-PEG7-aldehyde | Alkyl PEG Linkers. CAS No. 1058691-77-2. Molecular formula: C16H32O8. Mole weight: 352.42. Purity: 95%+. Catalog: ACM1058691772. | |
| mPEG7-Azide | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and reduced antigenicity. in addition to pegylation, activated peg derivatives can also be used to form networks for tissue engineering or drug delivery applications, depending on the architecture and reactivity. Group: Poly(ethylene glycol) and poly(ethylene oxide). Molecular formula: average Mn 7000. | |
| mPEG7-NH2 | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethanamine. Molecular formula: 339.42g/mol. Mole weight: C15H33NO7. COCCOCCOCCOCCOCCOCCOCCN. InChI= 1S / C15H33NO7 / c1-17-4-5-19-8-9-21-12-13-23-15-14-22 -11-10-20-7-6-18-3-2-16 / h2-16H2, 1H3. IQQSLHPGFFGOJW-UHFFFAOYSA-N. | |
| mPEG7-OH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: Methoxy-PEG7-Hydroxyl. Product ID: 2- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethanol. Molecular formula: 340.41g/mol. Mole weight: C15H32O8. [H]OCCOC. 1S/C3H8O2/c1-5-3-2-4/h4H,2-3H2,1H3. XNWFRZJHXBZDAG-UHFFFAOYSA-N. | |
| mPEG7-Propionic acid | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 3- [2- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] propanoic acid. Molecular formula: 412.5g/mol. Mole weight: C18H36O10. COCCOCCOCCOCCOCCOCCOCCOCCC(=O)O. InChI= 1S / C18H36O10 / c1-21-4-5-23-8-9-25-12-13-27-16-17-28 -15-14-26-11-10-24-7-6-22-3-2-18 (19) 20 / h2-17H2, 1H3, (H, 19, 20). JHUSQXBQANBSDC-UHFFFAOYSA-N. | |
| mPEG7-SH | Polyethylene glycol (PEG) compounds contain a polyether unit, commonly expressed as R1-(O-CH2-CH2)n-O-R2. They are generally biocompatible, non-toxic and stable in both organic and aqueous solutions, and so are extensively used in biological applications, as well as nanotechnology and materials research. Proteins with PEG chain modifications and compounds encapsulated in PEG liposomes exhibit a longer half-life in vivo than their non-PEGylated counterparts, a phenomenon known as PEG shielding. Functionalised PEG lipids and phospholipids can be used for protein-PEG conjugation. Uses: Activated peg derivatives can be used to modify peptides, proteins, or in other bioconjugation applications. pegylated materials have found broad use in drug delivery systems, virology, and immunology, as the incorporation of peg improves pharmacological properties such as increased water solubility, enhanced resistance to degradation (protein hydrolysis), increased circulation half-life, and redu. Group: Poly(ethylene glycol) and poly(ethylene oxide). Product ID: 2- [2- [2- [2- [2- [2- (2-methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethanethiol. Molecular formula: 356.5g/mol. Mole weight: C15H32O7S. COCCOCCOCCOCCOCCOCCOCCS. InChI= 1S / C15H32O7S / c1-16-2-3-17-4-5-18-6-7-19-8-9-20-10- 11-21-12-13-22-14-15-23 / h23H, 2-15H2, 1H3. PVSKDHZQTUFAEZ-UHFFFAOYSA-N. | |
| m-PEG8-O-alkyne | CuAAC & Thiol-Yne & Spontaneous Amino-Yne Click Reaction. Group: Terminal alkynes. Alternative Names: 2,5,8,11,14,17,20,23,26-Nonaoxanonacos-28-yne. CAS No. 880081-81-2. Molecular formula: C20H38O9. Mole weight: 422.51. IUPACName: 3- [2- [2- [2- [2- [2- [2- [2- (2-Methoxyethoxy) ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] ethoxy] prop-1-yne. Canonical SMILES: COCCOCCOCCOCCOCCOCCOCCOCCOCC#C. Catalog: CCR880081812. | |
| m-PEG9-azide | CuAAC & SPAAC Click Reactions. Group: Azides. CAS No. 1354521-95-1. Molecular formula: C19H39N3O9. Mole weight: 453.53. Catalog: CCR1354521951. | |
| mPEG-AA | According to public information, mPEG-AA (mPEG-CM) is one of the excipients of Pfizer's and Moderna's COVID-19 vaccine. Product ID: PE-0343. Category: Excipients. Product Keywords: Pharmaceutical Excipients; Excipients; mPEG-AA; PE-0343. Sample Provided: Yes. Standard: In-house standard. Grade: Pharmaceutical grade. |  |
| mPEG-alginate | mPEG-alginate,methoxypolyethylene glycol-alginate is an AB block copolymer,Chitosan is a Natural polysaccharide can be used for drug delivery systems. Synonyms: methoxy polyethylene glycol-alginate. Product ID: MSMN-054. Category: Raw Materials. | |
| mPEG-amine (MW 2000) | mPEG-amine (mPEG-NH2) (MW 2000) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs [1]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: mPEG-NH2 (MW 2000). CAS No. 80506-64-5. Pack Sizes: 50 mg; 100 mg. Product ID: HY-140676. | |
| mPEG-amine (MW 5000) | mPEG-amine (mPEG-NH2) (MW 5000) is a modifier that can replace the sulfonic acid portion of the dye molecule to increase the water solubility of long-wavelength voltage-sensitive dyes (VSD) or Pittsburgh (PGH) dyes. mPEG-amine can also form amide bonds with carboxyl groups on the surface of microspheres under the mediation of EDC and Sulfo-NHS to form a PEG coating on the surface of fluorescent microspheres for large-scale rotational cytoplasmic flow studies [1] [2]. Uses: Scientific research. Group: Biochemical assay reagents. Alternative Names: mPEG-NH2 (MW 5000). CAS No. 80506-64-5. Pack Sizes: 100 mg; 250 mg. Product ID: HY-140677. | |
| mPEG-b-PLA (2k-5k) | mPEG-b-PLA is a biodegradable diblock copolymer. Synonyms: Methoxy poly(ethylene glycol)-b-poly(D,L-lactide). Product ID: MSMN-087. Category: Raw Materials. | |
| mPEG-b-PLA (2k-5k) | mPEG-b-PLA is a biodegradable diblock copolymer. Uses: Msmn-087. Synonyms: Methoxy poly(ethylene glycol)-b-poly(D,L-lactide). Grades: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 2,000, PLGA Mn 10,000) | mPEG-b-PLGA (PEG Mn 2,000, PLGA Mn 10,000). Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-039. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 2,000, PLGA Mn 11,500) | Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-036. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 2,000, PLGA Mn 3,000) | mPEG-b-PLGA (PEG Mn 2,000, PLGA Mn 3,000). Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-040. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 2,000; PLGA Mn 4,500) | Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-034. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 5,000, PLGA Mn 10,000) | Contains ≤500 ppm impurities by GC, including trace monomer and residual organics. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-042. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 5,000, PLGA Mn 15,000) | Contains ≤500 ppm impurities by GC, including trace monomer and residual organics. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-041. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 5,000, PLGA Mn 20,000) | Contains ≤500 ppm impurities by GC, including trace monomer and residual organics. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-035. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 5,000, PLGA Mn 5,000) | Contains ≤500 ppm impurities by GC, including trace monomer and residual organics. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-038. Category: Raw Materials. | |
| mPEG-b-PLGA (PEG Mn 5,000, PLGA Mn 7,000) | Amphiphilic block copolymers (AmBC) are made up of two chemically different homopolymer blocks. One of the block is hydrophilic and the other one is hydrophobic. These macromolecules have the properties to self-assemble when dissolved in an aqueous media. PEG-PLGA is one the most commonly used biodegradable amphiphilic block copolymers for drug delivery applications. PEG is the hydrophilic part and PLGA is the hydrophobic part. Synonyms: Poly(ethylene glycol) methyl ether-block-poly(lactide-co-glycolide). Product ID: MSMN-037. Category: Raw Materials. | |
| Mpeg bromoisobutyrate | Mpeg bromoisobutyrate. Group: Poly(ethylene glycol) and poly(ethylene oxide). Alternative Names: ATRP initiator; mPEG bromoisobutyrate; PEG methyl ether bromoisobutyrate; Poly(ethylene glycol) methyl ether 2-bromoisobutyrate; mPEG bromoisobutyrate 1000; PEG methyl ether bromoisobutyrate 1000; methoxyPolyethylene glycol bromoisobutyryl; mPEG ATRP. CAS No. 245070-97-7. | |
| mPEG-Chitosan | mPEG-Chitosan,methoxypolyethylene glycol-Chitosan is an AB block copolymer,Chitosan is a Medicinal polysaccharide polymer can be used for drug delivery systems. Synonyms: methoxy polyethylene glycol-Chitosan. Product ID: MSMN-053. Category: Raw Materials. | |
| mPEG-DMG | mPEG-DMG. Product ID: PE-0344. Category: Excipients. Product Keywords: Pharmaceutical Excipients; Excipients; mPEG-DMG; PE-0344. Sample Provided: Yes. Standard: In-house standard. Grade: Pharmaceutical grade. | |
| m-PEG-DMG (MW 2000) | m-PEG-DMG (MW 2000) is a PEG lipid for the preparation of liposomes and can be used in drug delivery studies [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 1019000-64-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W440821. | |
| Mpeg-dspe | Phosphatidylglycerol Series. Alternative Names: 1,2-Distearoyl-sn-glycero-3-phosphorylglycerol sodium salt. CAS No. 124011-52-5. Molecular formula: C42H82NaO10P. Mole weight: 801.1. Purity: 98%+. IUPACName: Sodium;2,3-dihydroxypropyl 2,3-di(octadecanoyloxy)propyl phosphate. Canonical SMILES: CCCCCCCCCCCCCCCCCC (=O)OCC (COP (=O) ([O-])OCC (CO)O)OC (=O)CCCCCCCCCCCCCCCCC. [Na+]. Catalog: ACM124011525. | |
| MPEG-maleimide | MPEG-maleimide. Group: Polyethylene (pe). CAS No. 99126-64-4. Molecular formula: ~5000. Mole weight: CH3O(C2H4O)n+1-CH2CH2 -C4H2NO2. | |
| mPEG-PCL-PPEEA | PCL has good compatibility and good solvent solubility,especially in aromatic compounds,ketones and polar solvents.It is widely used in controlled release drug carrier,cell and tissue culture medium. Synonyms: methoxy polyethylene glycol-Poly(ε-caprolactone)-PPEEA. Product ID: MSMN-063. Category: Raw Materials. | |
| mPEG-PLA-PPEEA | Polylactic acid (PLA) is a kind of non-toxic,non irritating synthetic polymer material with excellent biodegradability,compatibility and absorbability.It can be used as drug transport material and tissue engineering scaffold material. Synonyms: methoxy polyethylene glycol-Poly(D,L-lactide)-PPEEA. Product ID: MSMN-064. Category: Raw Materials. | |
| mPEG-PLGA | mPEG-PLGA is a mucus-penetrating polymer. mPEG-PLGA is a raw material to prepare nanomedicine [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 743423-15-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-164077. | |
| MPEP | MPEP is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC 50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP has anxiolytic-or antidepressant-like effects [1] [2]. MPEP is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 96206-92-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14609A. | |
| MPEP | MPEP is a selective mGlu5 receptor antagonist with IC50 of 36 nM, exhibiting no appreciable activity at mGlu1b/2/3/4a/7b/8a/6 receptors. Grades: >98%. CAS No. 96206-92-7. Molecular formula: C14H11N. Mole weight: 193.24. |  |
| MPEP hydrochloride | MPEP hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 219911-35-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MPEP Hydrochloride | MPEP Hydrochloride is a potent, selective, noncompetitive, orally active and systemically active mGlu5 receptor antagonist, with an IC 50 of 36 nM for completely inhibiting quisqualate-stimulated phosphoinositide (PI) hydrolysis. MPEP Hydrochloride has anxiolytic-or antidepressant-like effects [1] [2]. MPEP (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 219911-35-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14609. | |
| MPEP Hydrochloride | Potent and selective antagonist for metabotropic glutamate receptor subtype 5 (mGluR5); Systemically active in vivo. Synonyms: 2-Methyl-6-(phenylethynyl)pyridine Hydrochloride. Grades: >98%. CAS No. 219911-35-0. Molecular formula: C14H12ClN. Mole weight: 229.7. | |
| MPEP Hydrochloride (6-Methyl-2- (phenylethynyl) pyridine Hydrochloride) | A non-competitive, highly potent antagonist selective for mGlu5 receptors (IC50 = 36nM). Also a positive allosteric modulator of mGlu4 and weak anatagonist of nMDA receptors. Biologically active admitted systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as learning and memory, sleep, neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease. Group: Biochemicals. Grades: Highly Purified. CAS No. 96206-92-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MPGΔNLS, HIV related | It is a 27-residue peptide derived from the hydrophobic fusion peptide of HIV-1 gp41 (for efficient crossing of the cell membrane) and the hydrophilic nuclear localization sequence of SV40 large T antigen (for the nuclear addressing of the peptide). It contains a single mutation in which the second lysine in NLS has mutated to serine. Synonyms: H-Gly-Ala-Leu-Phe-Leu-Gly-Phe-Leu-Gly-Ala-Ala-Gly-Ser-Thr-Met-Gly-Ala-Trp-Ser-Gln-Pro-Lys-Ser-Lys-Arg-Lys-Val-OH. Grades: 97%. Molecular formula: C126H201N35O33S. Mole weight: 2766.27. | |
| MPH | MPH. Pack Sizes: Milligram Quantities: 50 mg. Order Number: CL230. |  www.prochemonline.com |
| m-Phenoxytoluene | m-Phenoxytoluene. Group: Biochemicals. Alternative Names: 1-Methyl-3-phenoxybenzene; 3-Methyldiphenyl ether; 3-Methylphenyl Phenyl Ether; 3-Phenoxytoluene; Phenyl m-Tolyl Ether; m-Methylphenyl Phenyl Ether. Grades: Highly Purified. CAS No. 3586-14-9. Pack Sizes: 10g. Molecular Formula: C13H12O, Molecular Weight: 184.23. US Biological Life Sciences. | Worldwide |
| m-Phenylene di(acetate) | Heterocyclic Organic Compound. CAS No. 108-58-7. Molecular formula: C10H10O4. Mole weight: 194.18. Catalog: ACM108587. | |
| m-Phenylenediamine | 1kg Pack Size. Group: Amines, Building Blocks, Organics. Formula: C6H8N2. CAS No. 108-45-2. Prepack ID 13219509-1kg. Molecular Weight 108.14. See USA prepack pricing. |  |
| m-Phenylenediamine | 1,3-phenylenediamine appears as colorless or white colored needles that turn red or purple in air. Melting point 64-66 C. Density 1.14 g / cm³. Flash point 280 F. May irritate skin and eyes. Toxic by skin absorption, inhalation or ingestion. Used in aramid fiber manufacture, as a polymer additive, dye manufacturing, as a laboratory reagent, and in photography.;DryPowder; OtherSolid; PelletsLargeCrystals, Liquid;WHITE CRYSTALS. TURNS RED ON EXPOSURE TO AIR.;Colorless or white colored needles that turn red or purple in air. Group: Polymers. Product ID: benzene-1,3-diamine. Molecular formula: 108.14g/mol. Mole weight: C6H8N2;C6H4(NH2)2;C6H8N2. C1=CC(=CC(=C1)N)N. InChI=1S/C6H8N2/c7-5-2-1-3-6 (8)4-5/h1-4H, 7-8H2. WZCQRUWWHSTZEM-UHFFFAOYSA-N. | |
| m-Phenylenediamine | 1,3-phenylenediamine appears as colorless or white colored needles that turn red or purple in air. Melting point 64-66 C. Density 1.14 g / cm³. Flash point 280 F. May irritate skin and eyes. Toxic by skin absorption, inhalation or ingestion. Used in aramid fiber manufacture, as a polymer additive, dye manufacturing, as a laboratory reagent, and in photography.;DryPowder; OtherSolid; PelletsLargeCrystals, Liquid;WHITE CRYSTALS. TURNS RED ON EXPOSURE TO AIR.;Colorless or white colored needles that turn red or purple in air. Group: Polymers. CAS No. 108-45-2. Product ID: benzene-1,3-diamine. Molecular formula: 108.14g/mol. Mole weight: C6H8N2;C6H4(NH2)2;C6H8N2. C1=CC(=CC(=C1)N)N. InChI=1S/C6H8N2/c7-5-2-1-3-6 (8)4-5/h1-4H, 7-8H2. WZCQRUWWHSTZEM-UHFFFAOYSA-N. | |
| m-Phenylenediamine | m-Phenylenediamine. Group: Biochemicals. Alternative Names: 1,3-Diaminobenzene. Grades: Highly Purified. CAS No. 108-45-2. Pack Sizes: 5kg. US Biological Life Sciences. | Worldwide |
| m-Phenylenediamine 99+.9% | m-Phenylenediamine 99+.9%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 108-45-2. Pack Sizes: 25Kg, 100Kg. US Biological Life Sciences. | Worldwide |
| MPI-0479605 | MPI-0479605 is a potent and selective ATP competitive inhibitor of Mps1. Cells treated with MPI-0479605 undergo aberrant mitosis, resulting in aneuploidy and formation of micronuclei. In cells with wild-type p53, this promotes the induction of a postmitotic checkpoint characterized by the ATM- and RAD3-related-dependent activation of the p53-p21 pathway. In both wild-type and p53 mutant cells lines, there is a growth arrest and inhibition of DNA synthesis. Subsequently, cells undergo mitotic catastrophe and/or an apoptotic response. In xenograft models, MPI-0479605 inhibits tumor growth, suggesting that drugs targeting Mps1 may have utility as novel cancer therapeutics. Synonyms: MPI-0479605; MPI 0479605; MPI0479605. Grades: 0.98. CAS No. 1246529-32-7. Molecular formula: C22H29N7O. Mole weight: 407.522. | |
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