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| Product | Description | |
|---|---|---|
| MRT67307 | This active molecular is a potent ULK1/2 inhibitor and the IC50 value is 2.9 nM and 1.1 nM. MRT68921 is also a SIK inhibitor. Synonyms: MRT67307; MRT 67307; MRT-67307; N- [3- [ [5-cyclopropyl-2- [3- (morpholin-4-ylmethyl) anilino] pyrimidin-4-yl] amino] propyl] cyclobutanecarboxamide, 1190379-70-4 (HCl). Grades: 98%. CAS No. 1190378-57-4. Molecular formula: C26H36N6O2. Mole weight: 464.61. |  |
| MRT67307 | MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC 50 s of 160 and 19 nM, respectively [1]. MRT67307 also inhibits ULK1 and ULK2 with IC 50 s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190378-57-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13018. |  |
| MRT 67307 dihydrochloride | MRT 67307 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MRT 67307 dihydrochloride | MRT 67307 is a salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively). MRT67307 potently inhibits ULK1 and ULK2 in vitro and block autophagy in cells. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 dihydrochloride; MRT67307 dihydrochloride; MRT-67307 dihydrochloride; N- [3- [ [5-Cyclopropyl-2- [ [3- (4-morpholinylmethyl) phenyl] amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C26H36N6O2.2HCl. Mole weight: 537.52. | |
| MRT67307 HCl | MRT67307 is a potent and dual IKK? and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. It is an inhibitor for ULK1 and ULK2 with IC50 value of 45 and 38nM, respectively. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 HCl; MRT-67307 HCl; MRT67307 HCl. Grades: 99.80 %. Molecular formula: C26H36N6O2· xHCl. Mole weight: 464.6 (free-base). | |
| MRT 68601 hydrochloride | MRT 68601 hydrochloride is a potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Synonyms: N- [3- [ [5-Cyclopropyl-2- [ [4- (4-morpholinyl) phenyl] amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide hydrochloride; MRT-68601 HCl; MRT 68601 HCl; MRT68601 HCl. Grades: ≥98% by HPLC. Molecular formula: C25H34N6O2.HCl. Mole weight: 487.04. | |
| MRT68921 | MRT68921 is an inhibitor of ULK1 and ULK2 with IC50 values of 2.9 and 1.1 nM, respectively. It inhibits ULK and blocks autophagy in cells. Synonyms: N- (3- ( (5-Cyclopropyl-2- ( (2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-6-yl) amino) pyrimidin-4-yl) amino) propyl) cyclobutanecarboxamide; Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-. Grades: ≥98%. CAS No. 1190379-70-4. Molecular formula: C25H34N6O. Mole weight: 434.58. | |
| MRT 68921 dihydrochloride | MRT 68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. It also inhibits autophagy in mouse embryonic fibroblasts. Synonyms: N- [3- [ [5-Cyclopropyl-2- [ (1, 2, 3, 4-tetrahydro-2-methyl-6-isoquinolinyl) amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide dihydrochloride; Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:1). Grades: ≥98% by HPLC. CAS No. 2080306-21-2. Molecular formula: C25H34N6O.2HCl. Mole weight: 507.50. | |
| MRT-83 | MRT-83 is a potent antagonist of Smo , with an IC 50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. Uses: Scientific research. Group: Signaling pathways. CAS No. 1263131-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287. | |
| MRT-83 | This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing greater potency than cyclopamine, another Smoothened antagonist. MRT-83 efficiently antagonizes Hh signaling in vivo. MRT-83 will be useful for manipulating Hh signaling and may help develop new treatment for Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83; MRT 83; MRT83; N-[5-[[imino[ (3, 4, 5-trimethoxybenzoyl) amino]methyl]amino]-2-methylphenyl]-[1, 1'-Biphenyl]-4-carboxamide; 1359944-60-7 (HCl salt). Grades: 98%. CAS No. 1263131-92-5. Molecular formula: C31H30N4O5. Mole weight: 538.59. | |
| MRT-83 hydrochloride | MRT-83 is a Smoothened (Smo) antagonist. It can block Hedgehog (Hh) signaling in various assays. MRT-83 can also inhibit Bodipy-cyclopamine binding to human and mouse Smo. MRT-83 can efficiently antagonize Hh signaling in vivo. MRT-83 may help develop new therapies for the treatment of Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83 hydrochloride; MRT 83 hydrochloride; MRT83 hydrochloride; N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;1263131-92-5 (free base). Grades: 98%. CAS No. 1359944-60-7. Molecular formula: C31H31ClN4O5. Mole weight: 575.06. | |
| MRT-83 hydrochloride | MRT-83 (hydrochloride) is the potent antagonist of Smoothened ( Smo ) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359944-60-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287A. | |
| MRT-92 | MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Synonyms: MRT-92; MRT 92; MRT92. CAS No. 1428315-82-5. Molecular formula: C33H34N4O5. Mole weight: 566.657. | |
| MRT-92 HCl salt | MRT-92 is a selective Smoothened (Smo) receptor inhibitor. It shows subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (IC50 value is 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs, so MRT-92 may be become a drug candidate for treatment of cancer. Uses: Cancer. Synonyms: MRT-92 HCl salt; MRT 92 HCl salt; MRT92 HCl salt; 3, 4, 5-trimethoxy-N- (N- (4-methyl-3- (4-phenethylbenzamido) phenyl) carbamimidoyl) benzamide hydrochloride. Grades: 98%. CAS No. 1428307-52-1. Molecular formula: C33H35ClN4O5. Mole weight: 603.13. | |
| MRTX0902 | MRTX0902 is a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. Oral administration of MRTX0902 in combination with MRTX849 results in a significant increase in antitumor activity relative to that of either single agent, including tumor regressions in a subset of animals in the MIA PaCa-2 tumor mouse xenograft model. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRTX0902; MRTX-0902; MRTX 0902. Appearance: Solid powder. CAS No. 2654743-22-1. Molecular formula: C22H24N6O. Mole weight: 388.48. Purity: >98%. IUPACName: (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido-[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile. Canonical SMILES: N#CC1=CC=CC([C@H](NC2=NN=C(C)C3=CN=C(N4CCOCC4)C=C32)C)=C1C. Product ID: ACM2654743221. Alfa Chemistry ISO 9001:2015 Certified. |  |
| MRTX0902 | MRTX0902 is an orally active and potent SOS1 inhibitor with an IC 50 of 46 nM (WO2021127429A1; Example 12-10) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2654743-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145926. | |
| MRTX1133 | MRTX1133 Inhibitor. Uses: Scientific use. Product Category: T9303. CAS No. 2621928-55-8. |  |
| MRTX1133 | MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRTX1133; MRTX-1133; MRTX 1133. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2621928-55-8. Molecular formula: C33H31F3N6O2. Mole weight: 600.65. Purity: >98%. IUPACName: 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-. Canonical SMILES: OC1=CC(C2=C(F)C3=NC(OC[C@@]45CCCN4C[C@H](F)C5)=NC(N6CC(N7)CCC7C6)=C3C=N2)=C8C(C#C)=C(F)C=CC8=C1. Product ID: ACM2621928558. Alfa Chemistry ISO 9001:2015 Certified. | |
| MRTX1257 | MRTX1257 is a KRAS G12C inhibitor. MRTX1257 inhibits KRAS-dependent ERK phosphorylation in the H358 cell assay with IC50 of 900 pM. Synonyms: MRTX-1257; 2206736-04-9; MRTX1257; CHEMBL4632935; 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile. CAS No. 2206736-04-9. Molecular formula: C33H39N7O2. Mole weight: 565.7. | |
| MRTX849 | MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. Uses: Antineoplastic agents. Synonyms: MRTX-849; MRTX 849; Adagrasib; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile. CAS No. 2326521-71-3. Molecular formula: C32H35ClFN7O2. Mole weight: 604.12. | |
| MRTX849 | MRTX849 Inhibitor. Uses: Scientific use. Product Category: T8369. CAS No. 2326521-71-3. | |
| MRX-1024 | MRX-1024 is a proprietary oral formulation of D-methionine with antioxidant and antimucositis activities. D-methionine formulation MRX-1024 may selectively protect the oral mucosa from the toxic effects of chemotherapy and radiation therapy without compromising antitumor activity. D-methionine may be converted into the L- isomer in vivo, particlualry in instances of L-methionine deprivation, both isomers have antioxidant activity which may be due, in part, to their sulfur moieties and chelating properties. L-methionine, an essential amino acid, also may help to maintain the ratio of reduced glutathione to oxidized glutathione in cells undergoing oxidative stress and may provide a source of L-cysteine for glutathione synthesis. Synonyms: Methionine; D-Methionine; (R)-Methionine; NSC 45689; S-Methyl-D-homocysteine; H-D-Met-OH; (R)-2-amino-4-(methylthio)butanoic acid; D-2-Amino-4-(methylthio)butyric acid. Grades: ≥97%. CAS No. 348-67-4. Molecular formula: C5H11NO2S. Mole weight: 149.21. | |
| MRX-2843 | MRX-2843 is a dual inhibitor of MerTK and FLT3 with IC50 values of 1.3 and 1 nM, respectively. It induces apoptosis and inhibits colony formation in AML cell lines and other tumor cells expressing MERTK and/or FLT3-ITD. Treatment with MRX-2843 significantly prolonged survival of AML mouse models. Synonyms: 4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol. Grades: ≥95%. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. | |
| MRX-2843 | MRX-2843, also known as UNC2371, is a potent and orally active MERTK and FLT3 inhibitor. MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. MRX-2843 in combination with an irreversible EGFR TKI as a novel strategy for treatment of patients with wtEGFR NSCLC. MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: MRX-2843; MRX 2843; MRX2843; UNC2371; UNC-2371; UNC 2371; UNC2371A; UNC-2371A; UNC 2371A. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. Purity: >95%. IUPACName: (1r,4r)-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol. Canonical SMILES: O[C@H]1CC[C@H](N2C=C(C3=CC=C(CN4CCN(C)CC4)C=C3)C5=CN=C(NCCC6CC6)N=C52)CC1. Product ID: ACM1429882074. Alfa Chemistry ISO 9001:2015 Certified. | |
| MS0022 | MS0022 is a SMO antagonist. It showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low μM range. It reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. It is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo. Uses: Ms0022 is a treatment led to a transient delay of tumor growth. Synonyms: MS-0022; MS 0022; MS0022. 2-Bromo-N-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide. Grades: 98%. CAS No. 691392-89-9. Molecular formula: C21H16BrN3O. Mole weight: 406.28. | |
| MS023 | MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but was completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Synonyms: MS023; MS-023; MS 023. Grades: 98%. CAS No. 1831110-54-3. Molecular formula: C17H25N3O. Mole weight: 287.41. | |
| MS 023 dihydrochloride | MS 023 is a potent and selective type I PRMT inhibitor (IC50= 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 μM. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Synonyms: MS 023 dihydrochloride; MS023 dihydrochloride; MS-023 dihydrochloride; N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C17H25N3O.2HCl. Mole weight: 360.32. | |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective and cell-active human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. Synonyms: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride; N-{[4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl]methyl}-N-methyl-1,2-ethanediamine dihydrochloride; 1,2-Ethanediamine, N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-, hydrochloride (1:2). Grades: ≥95%. CAS No. 1992047-64-9. Molecular formula: C17H27Cl2N3O. Mole weight: 360.32. | |
| MS023 hydrochloride | Cas No. 2108631-19-0. | |
| MS049 | MS049 is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 μM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. Synonyms: MS-049; MS 049; N-Methyl-2-(4-phenylmethoxypiperidin-1-yl)ethanamine. CAS No. 1502816-23-0. Molecular formula: C15H24N2O. Mole weight: 248.36. | |
| MS049 hydrochloride | MS049 is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 μM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. Synonyms: MS049 HCl; MS049 Dihydrochloride; MS-049 hydrochloride; MS 049 hydrochloride; N-methyl-2-(4-phenylmethoxypiperidin-1-yl)ethanamine dihydrochloride. Grades: ≥98%. CAS No. 2095432-59-8. Molecular formula: C15H24N2O·2HCl. Mole weight: 321.3. | |
| MS049 oxalate salt | MS049 oxalate salt is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 μM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. Synonyms: MS049 oxalate salt; MS 049 oxalate salt; MS-049 oxalate salt; N-Methyl-4-(phenylmethoxy)-1-piperidineethanamine oxalate salt. Grades: ≥98% by HPLC. Molecular formula: C15H24N2O.C2H2O4. Mole weight: 338.4. | |
| MS-073 | MS-073 is a Type II DNA topoisomerase inhibitor under the development of Nihon Schering. MS-073 can overcome MDR in vitro and in vivo compare to verapamil. MS-073 at 0.1 mM can almost completely reverse in vitro resistance to vincristine in vincristine-resistant P388 cells. MS-073 can also reverse in vitro vincristine, adriamycin, etoposide, and actinomycin D resistance in adriamycin-resistant human myelogenous leukemia K562 cells. MS-073 reverses MDR through competitively inhibiting drug binding to P-glycoprotein. Treatment for cancer was discontinued. Uses: Cancer. Synonyms: MS-073; MS073; MS 073; CP-162398; CP-162398; CP 162398; CP162398; 1-(Quinolin-5-yloxy)-3-[4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten)-5-yl]piperazin-1-yl]-2-propanol. Grades: 98%. CAS No. 129716-45-6. Molecular formula: C31H33N3O2. Mole weight: 479.62. | |
| MS-1020 | Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression. Group: Biochemicals. Alternative Names: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphthamide. Grades: Highly Purified. CAS No. 1255516-86-9. Pack Sizes: 1mg. Molecular Formula: C21H18N2O3. US Biological Life Sciences. | Worldwide |
| MS-1020 | MS-1020 is a selective, cell-permeable inhibitor of Janus kinase 3 (JAK3). It potently inhibited persistently-active STAT3 in a cell type-specific manner, and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling. Synonyms: MS 1020; MS1020; 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide. Grades: ≥95%. CAS No. 1255516-86-9. Molecular formula: C21H18N2O3. Mole weight: 346.4. | |
| MS15 | MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC 50 values of 798 nM, 90 nM, and 544 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3035638-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-151613. | |
| MS 15203 | MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). It has also been shown to increases neuronal activity in the paraventricular nucleus, and to ncrease food intake and body weight in mice. Synonyms: MS0015203; MS-0015203; MS 0015203; 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 73912-52-4. Molecular formula: C12H11NO5. Mole weight: 249.22. | |
| MS170 | MS170 is a potent and selective PROTAC AKT degrader. MS170 depletes cellular total AKT (T-AKT) with the DC 50 value of 32 nM. MS170 binds to AKT1, AKT2, and AKT3 with K d s of 1.3 nM, 77 nM, and 6.5 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376136-61-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-145282. | |
| MS21 | MS21, a novel degrader of AKT , selectively inhibits the growth of PI3K/PTEN pathway-mutant cancers with wild-type KRAS and BRAF. Uses: Scientific research. Group: Signaling pathways. CAS No. 2376137-05-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-141807. | |
| MS 21570 | MS 21570, a GPR171 antagonist (IC50 = 220 nM), inhibits BigLEN mediated increases in [35S]GTPγS binding in hypothalamic membranes and hyperpolarization of basolateral amygdala pyramidal neurons. Synonyms: N-Methyl-5-[(phenylmethyl)thio]-1,3,4-thiazadiazol-2-amine; MS21570; MS-21570; MS 21570. Grades: ≥98% by HPLC. CAS No. 65373-29-7. Molecular formula: C10H11N3S2. Mole weight: 237.34. | |
| MS 245 oxalate | MS 245 oxalate. Group: Biochemicals. Grades: Purified. CAS No. 275363-58-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MS 245 Oxalate | MS 245 oxalate is a 5-HT6 antagonist with high affinity (Ki = 2.1 nM). It potentiates the hypolocomotor actions of (-)-nicotine in mice. Synonyms: MS 245 oxalate; MS245 oxalate; MS-245 oxalate; 5-Methoxy-N,N-dimethyl-1-(phenylsulfonyl)-1H-indole-3-ethanamine oxalate. Grades: ≥99% by HPLC. CAS No. 275363-58-1. Molecular formula: C21H24N2O7S. Mole weight: 448.49. | |
| MS-275 | HDAC 1 inhibitor. Antitumor compound. Antiproliferative. TGF-beta type II receptor inducer. Apoptosis inducer. Anti-inflammatory. Angiogenesis inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 209783-80-2. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C21H20N4O3. US Biological Life Sciences. | Worldwide |
| MS-275 (Entinostat, SNDX-275) | Preferentially inhibits HDAC1 (IC50=300 nM) over HDAC3 (IC50=8uM). Has no inhibitory activity towards HDAC8 (IC50>100uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 209783-80-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MS-282a | MS-282a is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 3.8 μmol/L. It has anti-gram-positive bacteria activity. Synonyms: MS-282-A. CAS No. 152158-04-8. Molecular formula: C37H65NO7. Mole weight: 635.91. | |
| MS-282b | MS-282b is produced by the strain of Streptomyces tauricus. It inhibits calmodulin-dependent MLCK with an IC50 of 5.2 μmol/L. It has anti-gram-positive bacteria activity. Synonyms: MS-282-B. CAS No. 152759-50-7. Molecular formula: C37H65NO7. Mole weight: 635.91. | |
| MS351 | MS351 is an antagonist of chromobox 7 (CBX7) that acts by binding the CBX7 chromodomain (CBX7ChD). It inhibits H3K27me3 binding to promote the binding of long noncoding RNA to the CBX7ChD. It effectively induces transcriptional derepression of CBX7 target genes. Synonyms: MS-351; MS 351; 1-(3,4-dichlorophenyl)-2-[2-imino-3-[(2-methylphenyl)methyl]benzimidazol-1-yl]ethanol hydrochloride. Grades: ≥98%. CAS No. 472984-79-5. Molecular formula: C23H21Cl2N3O·HCl. Mole weight: 462.8. | |
| MS37452 | MS37452 is a competitive inhibitor of CBX7 chromodomain (CBX7ChD) binding to H3K27me3 (Ki = 43 μM). It inhibits CBX7ChD binding to H3K27me3 at the INK4A/ARF locus, inducing transcriptional de-repression of p16/CDKN2A in PC3 prostate cancer cells. Synonyms: MS-37452; MS 37452; 1-[4-(2,3-Dimethoxybenzoyl)piperazin-1-yl]-2-(3-methylphenoxy)ethanone; 1-(2,3-dimethoxybenzoyl)-4-[(3-methylphenoxy)acetyl]piperazine. Grades: ≥98%. CAS No. 423748-02-1. Molecular formula: C22H26N2O5. Mole weight: 398.5. | |
| MS39 | MS39 (compound 6) is a PROTAC targeting EGFR. MS39 is composed of PROTAC target protein ligand N-(3-Chloro-4-fluorophenyl)-7-methoxy-6-(3-(piperazin-1-yl)propoxy)quinazolin-4-amine (HY-W109039) (red part), E3 ligase ligand (S,R,S)-AHPC (HY-125845) (blue part) and PROTAC Linker Undecanedioic acid (HY-W014125) (black part), among which the conjugate of E3 ubiquitin ligase ligand + Linker is (S,R,S)-AHPC-CO-C9-acid (HY-139345). MS39 reduces the expression of EGFR and downstream signaling in HCC-827 and H3255 cells. MS39 inhibits the proliferation of H3255 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2675490-92-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-157581. | |
| MS41 | MS41 is a selective eleven-nineteen leukemia (ENL) PROTAC degrader, with DC 50 s of 3.50 nM (MV4;11), 2.84 nM (SEMK2), 3.03 nM (Jurkat), and 26.58 nM (KASUMI1), respectively. MS41 effectively inhibits the growth of ENL-dependent leukemia cells, induces G1 cell cycle arrest and increases apoptosis. MS41 reduces the chromatin occupancy of ENL-associated transcription elongation machinery, and suppresses oncogenic gene expression and leukemia progression. Red: ENL ligand (HY-169094). Black: linker (HY-W105744). Blue: VHL ligand (HY-112078) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2768610-97-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-169093. | |
| MS436 | MS436 is a BRD4 bromodomain inhibitor, which exhibits 10-fold selectivity for BRD4(1) over BRD4(2). Synonyms: MS-436; MS 436. Grades: >98%. CAS No. 1395084-25-9. Molecular formula: C18H17N5O3S. Mole weight: 383.42. | |
| MS438 | MS438 is a potent thyrotropin receptor ( TSHR ) agonist with an EC 50 of 53 nM. MS438 binds to the serpentine portion of the TSHR. MS438 induces T4 secretion in mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 512840-45-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-114918. | |
| MS-444 | MS-444, originally isolated from Micromonospora sp. KY7123, is a myosin light chain kinase (MLCK) inhibitor. Synonyms: 5,8-Dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone; MS 444; 5,8-dihydroxy-3-methyl-9H-benzo[f][2]benzofuran-4-one. CAS No. 150045-18-4. Molecular formula: C13H10O4. Mole weight: 230.22. | |
| MS-681a | MS-681a, originally isolated from Myrothecium sp. KY6568, is a myosin light chain kinase (MLCK) inhibitor (IC50=0.11 μmol/L). CAS No. 173485-72-8. Molecular formula: C61H91N13O9. Mole weight: 1150.45. | |
| MSA-2 | An orally available non-nucleotide STING agonist, with EC50s of 8.3 and 24 μM for human STING isoforms WT and HAQ, respectively. Grades: >98%. CAS No. 294425-81-6. Molecular formula: C14H14O5S. Mole weight: 294.32. | |
| MSA-2 | MSA-2 Inhibitor. Uses: Scientific use. Product Category: T8798. CAS No. 129425-81-6. | |
| MSAB | MSAB is a Wnt/β-catenin signaling inhibitor. It has selective and potent anti-tumor effects on Wnt-dependent cancer cells. MSAB binds to β-catenin, promotes its degradation, and specifically down-regulates Wnt/β-catenin target genes. Grades: 98%. CAS No. 173436-66-3. Molecular formula: C15H15NO4S. Mole weight: 305.4. | |
| MSAB | MSAB is a potent and selective inhibitor of Wnt/β-catenin signaling. MSAB binds to β-catenin and promotes its degradation, and specifically downregulates Wnt/β-catenin target genes. MSAB exhibits potent anti-tumor effects selectively on Wnt-dependent cancer cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 173436-66-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-120697. | |
| m-Salicylic Acid | m-Salicylic Acid is widely used in organic synthesis. It is also an important active metabolite of aspirin (A187780). Group: Biochemicals. Alternative Names: 3-Hydroxybenzoic Acid; 3-Carboxyphenol; NSC 55746; m-Carboxyphenol; m-Hydroxybenzoic Acid. Grades: Highly Purified. CAS No. 99-06-9. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| MSB-2311 | MSB-2311 is a second-generation programmed cell death 1 ligand 1 (PD-L1) antibody with pH-dependent antigen binding property. The pH-dependent antigen binding property allows recycle of MSB-2311 in tumor cells and much longer residence time. Studies show that MSB-2311 is active in multiple tumor models. Uses: Pd-l1 antibody. Synonyms: Betifisolimab; MSB-2311; MSB 2311; MSB2311. CAS No. 2460539-60-8. | |
| MSBN | MSBN is a highly selective fluorogenic probe for thiols. MSBN can be used to image thiols in live cells selectively and specifically label protein thiols with a signal to determine various reversible protein thiol modifications [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 135980-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-119493. | |
| MSC-2032964A | MSC-2032964A acts as a selective apoptosis signal-regulating kinase 1(ASK1) inhibitor suppressing neuroinflammation with IC50 value of 93 nM in mice. It blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. It suppresses neuroinflammation in a mouse EAE model. It is orally bioavailable and brain penetrant. Synonyms: MSC2032964A; MSC 2032964A; N-[5-(Cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-3-pyridinecarboxamide; N-(5-(cyclopropylamino)-7-(trifluoromethyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl)nicotinamide; 3-Pyridinecarboxamide, N-[5-(cyclopropylamino)-7-(trifluoromethyl)[1,2,4]triazolo[1,5-a]pyridin-2-yl]-. Grades: >98%. CAS No. 1124381-43-6. Molecular formula: C16H13F3N6O. Mole weight: 362.32. | |
| MSC2530818 | MSC2530818 is a specific and orally available CDK8 inhibitor with an IC50 of 2.6 nM for CDK8. Synonyms: MSC2530818; MSC-2530818; MSC 2530818. [(2S)-2-(4-chlorophenyl)pyrrolidin-1-yl]-(3-methyl-2H-pyrazolo[3,4-b]pyridin-5-yl)methanone; SCHEMBL17514257; s8387; AKOS032946259. CAS No. 1883423-59-3. Molecular formula: C18H17ClN4O. Mole weight: 340.81. | |
| MSC-4381 | MSC-4381 (MCT4-IN-1) is an orally active and selective monocarboxylate transporter 4 (MCT4/SLC16A3) inhibitor with an IC 50 of 77 nM and a K i of 11 nM. MSC-4381 targets to the cytosolic domain of MCT4. MSC-4381 results in lactate efflux inhibition and reduction of cellular viability in MCT4 high expressing cells. MSC-4381 has the potential for MCT4 transporter inhibition research [1]. MSC-4381 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MCT4-IN-1. CAS No. 2445185-57-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132301. | |
| m-Scrobiculin | Synonyms: Scrobiculin. CAS No. 15081-04-6. Molecular formula: C22H26O8. Mole weight: 418.44. | |
| MSD-819 | MSD-819 is extracted from Streptomycess ambofaciens. It has anti-gram-positive and anti-gram-negative bacteria activity. Synonyms: 2-Quinoxalinecarboxylicacid, 6-chloro-, 1,4-dioxide; 3-Carboxy-7-chloro-1-oxoquinoxalin-1-ium-4(1H)-olate. CAS No. 22587-15-1. Molecular formula: C9H5ClN2O4. Mole weight: 240.60. | |
| MSD-92 | It is originally isolated from Actinomyces sp. MSD-92 has anti-gram-positive and anti-gram-negative activity, and the MIC of it against Escherichia coli was 2 μg/mL. Synonyms: 2-Methylfervenulone; BRN 0540815; 2,8-Dihydro-2,6,8-trimethylpyrimido(5,4-e)-as-triazine-3,5,7-trione. CAS No. 22712-32-9. Molecular formula: C8H9N5O3. Mole weight: 223.19. | |
| MSDC 0160 | MSDC 0160 (Mitoglitazone) is a mitochondrial target of thiazolidinediones (mTOT)-modulating insulin sensitizer and a modulator of mitochondrial pyruvate carrier (MPC). MSDC 0160 is a thiazolidinedione (TZD) with antidiabetic and neuroprotective activities. MSDC 0160 has the potential for Alzheimers disease [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mitoglitazone; CAY10415. CAS No. 146062-49-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100550. | |
| MSDC-0160 | MSDC-0160 reduces resistance in the insulin/IGF-1 signaling pathway and restores IGF-1-induced Akt and GSK-3 phosphorylation. Synonyms: Mitoglitazone; CAY10415; 5-[[4-[2-(5-Ethyl-2-pyridinyl)-2-oxoethoxy]phenyl]methyl]-2,4-thiazolidinedione; Pioglitazone Ketone; 5-(4-(2-(5-ethylpyridin-2-yl)-2-oxoethoxy)benzyl)thiazolidine-2,4-dione; 5-{4-[2-(5-ethylpyridin-2-yl)-2-oxoethoxy]benzyl}-1,3-thiazolidine-2,4-dione. Grades: >98%. CAS No. 146062-49-9. Molecular formula: C19H18N2O4S. Mole weight: 370.42. | |
| MSDC-0602 | MSDC-0602 is an insulin sensitizer that has the potential to treat diabetes and other inflammatory diseases. It exhibits low affinity for binding and activation of PPAR&gamma. Synonyms: MSDC-0602; MSDC0602; MSDC 0602; 5-{4-[2-(3-Methoxyphenyl)-2-oxoethoxy]benzyl}-1,3-thiazolidine-2,4-dione; 2,4-Thiazolidinedione, 5-[[4-[2-(3-methoxyphenyl)-2-oxoethoxy]phenyl]methyl]-. CAS No. 1133819-87-0. Molecular formula: C19H17NO5S. Mole weight: 371.407. | |
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