A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Search for products or services, then visit the suppliers website for prices or more information.
| Product | Description | |
|---|---|---|
| MRS 1845 | MRS 1845 is a potent SOCE inhibitor that can block Ca2+ capacitative entry resulting in an antiinflammatory effect. MRS 1845 inhibits capacitative Ca2+ influx in HL-60 cells (IC50 = 1.7 mM). Synonyms: MRS 1845; MRS1845; MRS-1845; N-PROPARGYLNITRENDIPENE; MRS 1845; 1,4-DIHYDRO-2,6-DIMETHYL-4-(3-NITROPHENYL)-1-(2-PROPYNYL)-3,5-PYRIDINEDICARBOXYLIC ACID ETHYL, METHYL ESTER; 1, 4-Dihydro-2, 6-di methyl -4- (3-nitrophenyl) -1- (2-propynyl) -3, 5-pyridinedicarboxylicacidethyl methyl ester. Grades: ≥98% by HPLC. CAS No. 544478-19-5. Molecular formula: C21H22N2O6. Mole weight: 398.41. |  |
| MRS 1845 | MRS 1845. Group: Biochemicals. Grades: Purified. CAS No. 544478-19-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MRS 2159 | DBO-83 is an agonist of nicotinic acetylcholine receptors (nAChRs), which has anti-injury and anti-forgetting effects. DBO-83 dose-dependently increased the incubation period of paw licking in hot plate mice and decreased the number of abdominal coarctation in acetic acid mice, which was reduced by the nAChR antagonist mecamylamine. Grades: ≥98%. CAS No. 195211-53-1. Molecular formula: C15H11N3O8PNa3. Mole weight: 461.21. | |
| MRS2179 ammonium salt | MRS2179 is a competitive P2Y1 receptor antagonist that inhibits platelet aggregation. Grades: ≥98%. CAS No. 228264-19-5. Molecular formula: C11H17N5O9P2·xNH3. Mole weight: 425.23. | |
| MRS 2179 tetrasodium salt | MRS 2179 tetrasodium salt is a competitive antagonist at P2Y1 receptors (KB = 100 nM), which is selective over P2X1 (IC50 = 1.15 μM), P2X3 (IC50 = 12.9 μM), P2X2, P2X4, P2Y2, P2Y4 and P2Y6 receptors. It inhibits ADP-induced platelet shape change and aggregation (pA2 = 6.55) in vitro and prolongs bleeding time in rats and mice compared to controls. Synonyms: MRS 2179 tetrasodium salt; MRS2179 tetrasodium salt; MRS-2179 tetrasodium salt; 2'-Deoxy-N6-methyladenosine 3',5'-bisphosphate tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 1454889-37-2. Molecular formula: C11H13N5O9P2Na4. Mole weight: 513.16. | |
| MRS 2211 | MRS 2211 is a competitive P2Y13 receptor antagonist (pIC50 = 5.97), with > 20-fold selectivity over P2Y1 and P2Y12 receptors. It is known that MRS 2211 inhibits ADP-induced inositol trisphosphate (IP3) formation. Research suggests that MRS 2211 inhibits phospholipase C (PLC) response to 2-methylthio-ADP in 1321N1 astrocytoma cells. Synonyms: 2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde disodium salt; MRS2211; MRS-2211. Grades: ≥96% by HPLC. Molecular formula: C14H10N4O8Na2PCl. Mole weight: 474.66. | |
| MRS 2211 | MRS 2211. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2211 (2-[(2-Chloro-5-nitrophenyl)azo]-5-hydroxy-6-methyl-3-[(phosphonooxy)methyl]-4-pyridinecarboxaldehyde Sodium Salt, P2Y13 Purinergic Receptor Antagonist, MRS2211, MRS 2211, MRS-2211) | A highly selective and competitive antagonist of P2Y13 purinergic receptor (pIC50 = 5.97). Exhibits about 20-fold greater selectivity over P2Y1 and P2Y12 receptors. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MRS 2219 | MRS 2219. Group: Biochemicals. Grades: Purified. CAS No. 14141-47-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2219 | MRS 2219, a cyclic pyridoxine-alpha4, 5-monophosphate compound, is a selective potentiator of ATP-evoked responses at rat P2X1 receptors (EC50 = 5.9 μM). Synonyms: 1,5-Dihydro-3-hydroxy-8-methyl[1,3,2]dioxaphosphepino[5,6-c]pyridin-9-ol-3-oxide; MRS 2219; MRS-2219; MRS2219. Grades: ≥99% by HPLC. CAS No. 14141-47-0. Molecular formula: C8H10NO5P. Mole weight: 231.14. | |
| MRS 2279 | MRS 2279 is the first broadly applicable, selective and high affinity competitive antagonist radioligand for a P2Y receptor (Ki = 2.5 nM; IC50 = 51.6 nM). Synonyms: MRS2279; MRS-2279; MRS 2279. (1R*,2S*)-4-[2-Chloro-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester diammonium salt. Grades: ≥98% by HPLC. CAS No. 367909-40-8. Molecular formula: C13H18ClN5O8P2.2NH3. Mole weight: 503.78. | |
| MRS 2365 | MRS 2365 is a highly potent, selective P2Y1 receptor agonist (EC50 = 0.4 nM), with no activity at P2Y12 receptors and only very low agonist activity at P2Y13 receptors (at concentrations up to 1 μM). Synonyms: [[(1R,2R,3S,4R,5S)-4-[6-Amino-2-(methylthio)-9H-purin-9-yl]-2,3-dihydroxybicyclo[3.1.0]hex-1-yl]methyl] diphosphoric acid mono ester trisodium salt; MRS2365; MRS 2365; MRS-2365. Grades: ≥98% by HPLC. CAS No. 436847-09-5. Molecular formula: C13H16N5O9P2SNa3. Mole weight: 549.28. | |
| MRS 2500 tetraammonium salt | MRS 2500 tetraammonium salt is a highly potent and selective antagonist of the platelet P2Y1 receptor (Ki = 0.78 nM). It inhibits ADP-induced aggregation of human platelets. Synonyms: (1R*,2S*)-4-[2-Iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt; Bicyclo[3.1.0]hexane-1-methanol, 4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)-, dihydrogen phosphate (ester), tetraammonium salt, (1R,2S,4S,5S)-; MRS-2500 tetraammonium; (1R, 2S, 4S, 5S)-4-(2-iodo-6-(methylamino)-9H-purin-9-yl)-1-((phosphonooxy)methyl)bicyclo[3. 1. 0]hexan-2-yl dihydrogen phosphate, tetraammonia salt. Grades: ≥96% by HPLC. CAS No. 630103-23-0. Molecular formula: C13H18N5O8P2I.4NH3. Mole weight: 629.29. | |
| MRS 2500 tetraammonium salt | MRS 2500 tetraammonium salt. Group: Biochemicals. Alternative Names: (1R, 2S) -4-[2-[2-Iodo-6- (methylamino) -9H-purin-9-yl]-2- (phosphonooxy) bicyclo[3. 1. 0]hexane-1-methanol dihydrogen phosphate ester tetraammonium salt. Grades: Highly Purified. CAS No. 779323-43-2,630103-23-0. Pack Sizes: 1mg, 2mg, 5mg. Molecular Formula: C13H18N5O8P2I·4NH3. US Biological Life Sciences. | Worldwide |
| MRS 2578 | MRS 2578. Group: Biochemicals. Grades: Purified. CAS No. 711019-86-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRS 2578 | MRS2578 is a potent P2Y6 receptor antagonist with IC50 of 37 nM, exhibits insignificant activity at P2Y1, P2Y2, P2Y4,and P2Y11 receptors. Synonyms: MRS-2578; MRS2578; MRS 2578. Grades: >98%. CAS No. 711019-86-2. Molecular formula: C20H20N6S4. Mole weight: 472.67. | |
| MRS 2690 | MRS 2690 is a potent P2Y14 receptor agonist (EC50 = 49 nM), with 7-fold higher potency than UDP-glucose. Synonyms: Diphosphoric acid 1-α-D-glucopyranosyl ester 2-[(4'-methylthio)uridin-5''-yl] ester disodium salt; MRS2690; MRS-2690; MRS 2690. Grades: ≥98% by HPLC. CAS No. 15039-58-4. Molecular formula: C15H22N2Na2O16P2S. Mole weight: 626.33. | |
| MRS 2690 | MRS 2690. Group: Biochemicals. Grades: Purified. CAS No. 15039-58-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 2693 trisodium salt | MRS 2693 trisodium salt. Group: Biochemicals. Grades: Purified. CAS No. 1448858-83-0. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 2693 trisodium salt | MRS 2693 trisodium salt is a selective P2Y6 agonist (EC50 = 0.015 μM at the hP2Y6 receptor), with no activity at other P2Y subtypes. Synonyms: Uridine 5'-(trihydrogen diphosphate), 5-iodo-, sodium salt (1:3); MRS 2693; 5-Iodo-UDP Trisodium Salt; 5-Iodouridine 5'-(trihydrogen diphosphate) sodium salt; 5-Iodouridine-5'-O-diphosphate trisodium salt; MRS2693; MRS-2693. Grades: ≥95% by HPLC. CAS No. 1448858-83-0. Molecular formula: C9H10IN2Na3O12P2. Mole weight: 596.00. | |
| Mrs 2768 tetrasodium salt | Heterocyclic Organic Compound. CAS No. 1047980-83-5. Molecular formula: C15H16N2O18P4Na4. Mole weight: C15H16N2O18P4Na4. Purity: >98 %. Catalog: ACM1047980835. |  |
| MRS 2768 tetrasodium salt | MRS 2768 tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 1047980-83-5. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 2768 tetrasodium salt | MRS 2768 tetrasodium salt is a selective P2Y2 agonist (EC50 = 1.89 μM), with no affinity for human P2Y4 or P2Y6 receptors. Synonyms: Uridine-5'-tetraphosphate δ-phenyl ester tetrasodium salt; MRS 2768 tetrasodium salt; MRS2768 tetrasodium salt; MRS-2768 tetrasodium salt. Grades: ≥98% by HPLC. CAS No. 1047980-83-5. Molecular formula: C15H16N2O18P4Na4. Mole weight: 728.14. | |
| MRS 2905 | MRS 2905 is a potent and selective P2Y14 receptor agonist (EC50 = 0.92 nM), with >2000-fold selectivity over P2Y6. Synonyms: MRS 2905; MRS-2905; MRS2905; 2-Thiouridine-5'-O-(α, β-methylene)diphosphate trisodium salt. Grades: ≥98% by HPLC. Molecular formula: C10H13N2Na3O10P2S. Mole weight: 484.2. | |
| MRS 2957 triethylammonium salt | MRS 2957 triethylammonium salt 7 is a selective P2Y6 receptor agonists (EC50 = 12 nM) for the treatment of muscle wasting and neurodegeneration. It exhibits 14- and 66-fold selectivity against P2Y2 and P2Y4 receptors respectively. Synonyms: MRS 2957 triethylammonium salt; MRS2957 triethylammonium salt; MRS-2957 triethylammonium salt; P1-[5'(N4-Methoxycytidyl)]-P3-(5'-uridyl)-triphosphate tri(triethylammonium) salt. Grades: ≥99% by HPLC. CAS No. 1228271-30-4. Molecular formula: C19H28N5O20P3.3(C2H5)3N. Mole weight: 1042.94. | |
| MRS 2957 triethylammonium salt | MRS 2957 triethylammonium salt. Group: Biochemicals. Grades: Purified. CAS No. 1228271-30-4. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 3777 hemioxalate | MRS 3777 hemioxalate. Group: Biochemicals. Grades: Purified. CAS No. 1186195-57-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MRS 3777 hemioxalate | MRS 3777 hemioxalate is a high affinity adenosine A3 receptor antagonist (Ki = 47 nM), with > 200-fold selectivity versus A1, A2A and A2B receptors. It may be used in the modulation of blood platelet aggregation. Synonyms: MRS 3777 hemioxalate; MRS3777 hemioxalate; MRS-3777 hemioxalate; 2-Phenoxy-6-(cyclohexylamino)purine hemioxalate. Grades: ≥98% by HPLC. CAS No. 1186195-57-2. Molecular formula: C17H19N5O.½C2H2O4. Mole weight: 354.39. | |
| MRS 4062 triethylammonium salt | MRS 4062 is a hP2Y4 agonist with EC50 value of 23 nM, EC50 value of 640 nM to P2Y2 receptor and EC50 value of 740 nM to P2Y6 receptor. Synonyms: N4-Phenylpropoxycytidine-5'-O-triphosphate tetra(triethylammonium) salt; MRS4062; MRS 4062; MRS-4062; MRS 4062 triethylammonium salt. Grades: ≥99% by HPLC. CAS No. 1309871-50-8. Molecular formula: C18H26N3O15P3.4(C2H5)3N. Mole weight: 1022.09. | |
| MRS 4062 triethylammonium salt | MRS 4062 triethylammonium salt. Group: Biochemicals. Grades: Purified. CAS No. 1309871-50-8. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MRS 5698 | MRS 5698 is a high affinity and selective A3 adenosine receptor agonist (Ki ~ 3 nM), with >1000-fold selectivity over A1 and A2A adenosine receptors. It is becoming an important pharmacological tool for defining A3AR effects and is orally active in a chronic neuropathic pain model. Synonyms: (1S,2R,3S,4R,5S)-4-[6-[[(3-Chlorophenyl)methyl]amino]-2-[2-(3,4-difluorophenyl)ethynyl]-9H-purin-9-yl]-2,3-dihydroxy-N-methylbicyclo[3.1.0]hexane-1-carboxamide; MRS5698; MRS 5698; MRS-5698. Grades: ≥96% by HPLC. CAS No. 1377273-00-1. Molecular formula: C28H23ClF2N6O3. Mole weight: 564.97. | |
| MRT 10 | MRT 10 is a smoothened (Smo) receptor antagonist (IC50 = 0.5 μM in HEK293 cells transiently expressing mouse Smo). It also inhibits bodipy-cyclopamine binding to the murine Smo receptor (IC50 = 0.5 μM) when expressed in HEK293 cells. Synonyms: MRT 10; MRT10; MRT-10; N-[[[3-Benzoylamino) phenyl]amino]thioxomethyl]-3, 4, 5-trimethoxybenzamide. Grades: ≥98%. CAS No. 330829-30-6. Molecular formula: C24H23N3O5S. Mole weight: 465.52. | |
| MRT 10 | MRT 10. Group: Biochemicals. Grades: Purified. CAS No. 330829-30-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRT67307 | This active molecular is a potent ULK1/2 inhibitor and the IC50 value is 2.9 nM and 1.1 nM. MRT68921 is also a SIK inhibitor. Synonyms: MRT67307; MRT 67307; MRT-67307; N- [3- [ [5-cyclopropyl-2- [3- (morpholin-4-ylmethyl) anilino] pyrimidin-4-yl] amino] propyl] cyclobutanecarboxamide, 1190379-70-4 (HCl). Grades: 98%. CAS No. 1190378-57-4. Molecular formula: C26H36N6O2. Mole weight: 464.61. | |
| MRT67307 | MRT67307 is a dual inhibitor of the IKKε and TBK-1 with IC 50 s of 160 and 19 nM, respectively [1]. MRT67307 also inhibits ULK1 and ULK2 with IC 50 s of 45 and 38 nM, respectively. MRT67307 also blocks autophagy in cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1190378-57-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13018. |  |
| MRT 67307 dihydrochloride | MRT 67307 is a salt inducible kinase (SIK) inhibitor (IC50 values are 67, 250 and 430 nM for SIK2, SIK1 and SIK3 respectively). MRT67307 potently inhibits ULK1 and ULK2 in vitro and block autophagy in cells. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 dihydrochloride; MRT67307 dihydrochloride; MRT-67307 dihydrochloride; N- [3- [ [5-Cyclopropyl-2- [ [3- (4-morpholinylmethyl) phenyl] amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C26H36N6O2.2HCl. Mole weight: 537.52. | |
| MRT 67307 dihydrochloride | MRT 67307 dihydrochloride. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MRT67307 HCl | MRT67307 is a potent and dual IKK? and TBK1 inhibitor with IC50 of 160 and 19 nM, respectively. It is an inhibitor for ULK1 and ULK2 with IC50 value of 45 and 38nM, respectively. ULK1 inhibition results in accumulation of stalled early autophagosomal structures, indicating a role for ULK1 in the maturation of autophagosomes as well as initiation. Synonyms: MRT 67307 HCl; MRT-67307 HCl; MRT67307 HCl. Grades: 99.80 %. Molecular formula: C26H36N6O2· xHCl. Mole weight: 464.6 (free-base). | |
| MRT 68601 hydrochloride | MRT 68601 hydrochloride is a potent TBK1 (TANK-binding kinase-1) inhibitor (IC50 = 6 nM). Synonyms: N- [3- [ [5-Cyclopropyl-2- [ [4- (4-morpholinyl) phenyl] amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide hydrochloride; MRT-68601 HCl; MRT 68601 HCl; MRT68601 HCl. Grades: ≥98% by HPLC. Molecular formula: C25H34N6O2.HCl. Mole weight: 487.04. | |
| MRT68921 | MRT68921 is an inhibitor of ULK1 and ULK2 with IC50 values of 2.9 and 1.1 nM, respectively. It inhibits ULK and blocks autophagy in cells. Synonyms: N- (3- ( (5-Cyclopropyl-2- ( (2-methyl-1, 2, 3, 4-tetrahydroisoquinolin-6-yl) amino) pyrimidin-4-yl) amino) propyl) cyclobutanecarboxamide; Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-. Grades: ≥98%. CAS No. 1190379-70-4. Molecular formula: C25H34N6O. Mole weight: 434.58. | |
| MRT 68921 dihydrochloride | MRT 68921 is a potent and dual autophagy kinase ULK1/2 inhibitor with IC50 of 2.9 nM and 1.1 nM, respectively. It also inhibits autophagy in mouse embryonic fibroblasts. Synonyms: N- [3- [ [5-Cyclopropyl-2- [ (1, 2, 3, 4-tetrahydro-2-methyl-6-isoquinolinyl) amino] -4-pyrimidinyl] amino] propyl] cyclobutanecarboxamide dihydrochloride; Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[(1,2,3,4-tetrahydro-2-methyl-6-isoquinolinyl)amino]-4-pyrimidinyl]amino]propyl]-, hydrochloride (1:1). Grades: ≥98% by HPLC. CAS No. 2080306-21-2. Molecular formula: C25H34N6O.2HCl. Mole weight: 507.50. | |
| MRT-83 | MRT-83 is a potent antagonist of Smo , with an IC 50 in the nanomolar range. MRT-83 also blocks Hedgehog (Hh) signaling. Uses: Scientific research. Group: Signaling pathways. CAS No. 1263131-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287. | |
| MRT-83 | This active molecular is a novel potent Smoothened antagonist. MRT-83 blocks Hedgehog (Hh) signaling in various assays and IC50 can be in nmol range, showing greater potency than cyclopamine, another Smoothened antagonist. MRT-83 efficiently antagonizes Hh signaling in vivo. MRT-83 will be useful for manipulating Hh signaling and may help develop new treatment for Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83; MRT 83; MRT83; N-[5-[[imino[ (3, 4, 5-trimethoxybenzoyl) amino]methyl]amino]-2-methylphenyl]-[1, 1'-Biphenyl]-4-carboxamide; 1359944-60-7 (HCl salt). Grades: 98%. CAS No. 1263131-92-5. Molecular formula: C31H30N4O5. Mole weight: 538.59. | |
| MRT-83 hydrochloride | MRT-83 is a Smoothened (Smo) antagonist. It can block Hedgehog (Hh) signaling in various assays. MRT-83 can also inhibit Bodipy-cyclopamine binding to human and mouse Smo. MRT-83 can efficiently antagonize Hh signaling in vivo. MRT-83 may help develop new therapies for the treatment of Hh-pathway related diseases. Uses: Hh-pathway related diseases. Synonyms: MRT-83 hydrochloride; MRT 83 hydrochloride; MRT83 hydrochloride; N-(2-methyl-5-(3-(3,4,5-trimethoxybenzoyl)guanidino)phenyl)-[1,1'-biphenyl]-4-carboxamide hydrochloride;1263131-92-5 (free base). Grades: 98%. CAS No. 1359944-60-7. Molecular formula: C31H31ClN4O5. Mole weight: 575.06. | |
| MRT-83 hydrochloride | MRT-83 (hydrochloride) is the potent antagonist of Smoothened ( Smo ) receptor. MRT-83 (hydrochloride) inhibits the Hedgehog (Hh) signaling pathway and BODIPY-cyclopamine binding to human Smo. MRT-83 (hydrochloride) has the potential for researching cancer disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1359944-60-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18287A. | |
| MRT-92 | MRT-92 is a potent and selective Smoothened (Smo) receptor inhibitor. MRT-92 displays subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (half maximal inhibitory concentration [IC50] = 0.4 nM) or genetic manipulation. Synonyms: MRT-92; MRT 92; MRT92. CAS No. 1428315-82-5. Molecular formula: C33H34N4O5. Mole weight: 566.657. | |
| MRT-92 HCl salt | MRT-92 is a selective Smoothened (Smo) receptor inhibitor. It shows subnanomolar antagonist activity against Smo in various Hh cell-based assays. MRT-92 inhibits rodent cerebellar granule cell proliferation induced by Hh pathway activation through pharmacologic (IC50 value is 0.4 nM) or genetic manipulation. Smo is the target of anticancer drugs, so MRT-92 may be become a drug candidate for treatment of cancer. Uses: Cancer. Synonyms: MRT-92 HCl salt; MRT 92 HCl salt; MRT92 HCl salt; 3, 4, 5-trimethoxy-N- (N- (4-methyl-3- (4-phenethylbenzamido) phenyl) carbamimidoyl) benzamide hydrochloride. Grades: 98%. CAS No. 1428307-52-1. Molecular formula: C33H35ClN4O5. Mole weight: 603.13. | |
| MRTX0902 | MRTX0902 is a Potent, Selective, Brain-Penetrant, and Orally Bioavailable Inhibitor of the SOS1:KRAS Protein-Protein Interaction. Oral administration of MRTX0902 in combination with MRTX849 results in a significant increase in antitumor activity relative to that of either single agent, including tumor regressions in a subset of animals in the MIA PaCa-2 tumor mouse xenograft model. Alternative Names: MRTX0902; MRTX-0902; MRTX 0902. CAS No. 2654743-22-1. Molecular formula: C22H24N6O. Mole weight: 388.48. Appearance: Solid powder. Purity: >98%. IUPACName: (R)-2-Methyl-3-(1-((4-methyl-7-morpholinopyrido-[3,4-d]pyridazin-1-yl)amino)ethyl)benzonitrile. Canonical SMILES: N#CC1=CC=CC ([C@H] (NC2=NN=C (C)C3=CN=C (N4CCOCC4)C=C32)C)=C1C. Catalog: ACM2654743221. | |
| MRTX0902 | MRTX0902 is an orally active and potent SOS1 inhibitor with an IC 50 of 46 nM (WO2021127429A1; Example 12-10) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2654743-22-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145926. | |
| MRTX1133 | MRTX1133 is a potent and selective KRAS G12D inhibitor. MRTX1133 targets the KRAS G12D protein in both active and inactive states. In preclinical studies, MRTX1133 exhibited a long half-life, an ability to bind the KRAS G12D protein in both active and inactive states, and selective inhibition of KRAS G12D mutant cancer cells. In G12D mutant tumor models, MRTX1133 showed dose-dependent selective inhibition of the KRAS pathway and tumor regression. Group: Inhibitors. Alternative Names: MRTX1133; MRTX-1133; MRTX 1133. CAS No. 2621928-55-8. Molecular formula: C33H31F3N6O2. Mole weight: 600.65. Appearance: Solid powder. Purity: >98%. IUPACName: 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-. Canonical SMILES: OC1=CC (C2=C (F)C3=NC (OC[C@@]45CCCN4C[C@H] (F)C5)=NC (N6CC (N7)CCC7C6)=C3C=N2)=C8C (C#C)=C (F)C=CC8=C1. Catalog: ACM2621928558. | |
| MRTX1133 | MRTX1133 Inhibitor. Uses: Scientific use. Product Category: T9303. CAS No. 2621928-55-8. |  |
| MRTX1257 | MRTX1257 is a KRAS G12C inhibitor. MRTX1257 inhibits KRAS-dependent ERK phosphorylation in the H358 cell assay with IC50 of 900 pM. Synonyms: MRTX-1257; 2206736-04-9; MRTX1257; CHEMBL4632935; 2-[(2S)-4-[7-(8-methylnaphthalen-1-yl)-2-[[(2S)-1-methylpyrrolidin-2-yl]methoxy]-6,8-dihydro-5H-pyrido[3,4-d]pyrimidin-4-yl]-1-prop-2-enoylpiperazin-2-yl]acetonitrile. CAS No. 2206736-04-9. Molecular formula: C33H39N7O2. Mole weight: 565.7. | |
| MRTX849 | MRTX849 Inhibitor. Uses: Scientific use. Product Category: T8369. CAS No. 2326521-71-3. | |
| MRTX849 | MRTX849 is a potent and mutation-selective covalent inhibitor of KRAS G12C. It maximizes inhibition by irreversibly locking the KRAS molecule in its inactive state, thereby preventing tumor cell growth which results in tumor cell death. Uses: Antineoplastic agents. Synonyms: MRTX-849; MRTX 849; Adagrasib; 2-((S)-4-(7-(8-Chloronaphthalen-1-yl)-2-(((S)-1-methylpyrrolidin-2-yl)methoxy)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidin-4-yl)-1-(2-fluoroacryloyl)piperazin-2-yl)acetonitrile. CAS No. 2326521-71-3. Molecular formula: C32H35ClFN7O2. Mole weight: 604.12. | |
| MRX-1024 | MRX-1024 is a proprietary oral formulation of D-methionine with antioxidant and antimucositis activities. D-methionine formulation MRX-1024 may selectively protect the oral mucosa from the toxic effects of chemotherapy and radiation therapy without compromising antitumor activity. D-methionine may be converted into the L- isomer in vivo, particlualry in instances of L-methionine deprivation, both isomers have antioxidant activity which may be due, in part, to their sulfur moieties and chelating properties. L-methionine, an essential amino acid, also may help to maintain the ratio of reduced glutathione to oxidized glutathione in cells undergoing oxidative stress and may provide a source of L-cysteine for glutathione synthesis. Synonyms: Methionine; D-Methionine; (R)-Methionine; NSC 45689; S-Methyl-D-homocysteine; H-D-Met-OH; (R)-2-amino-4-(methylthio)butanoic acid; D-2-Amino-4-(methylthio)butyric acid. Grades: ≥97%. CAS No. 348-67-4. Molecular formula: C5H11NO2S. Mole weight: 149.21. | |
| MRX-2843 | MRX-2843 is a dual inhibitor of MerTK and FLT3 with IC50 values of 1.3 and 1 nM, respectively. It induces apoptosis and inhibits colony formation in AML cell lines and other tumor cells expressing MERTK and/or FLT3-ITD. Treatment with MRX-2843 significantly prolonged survival of AML mouse models. Synonyms: 4-[2-(2-cyclopropylethylamino)-5-[4-[(4-methylpiperazin-1-yl)methyl]phenyl]pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexan-1-ol. Grades: ≥95%. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. | |
| MRX-2843 | MRX-2843, also known as UNC2371, is a potent and orally active MERTK and FLT3 inhibitor. MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia. MRX-2843 in combination with an irreversible EGFR TKI as a novel strategy for treatment of patients with wtEGFR NSCLC. MRX-2843 treatment induces apoptosis and inhibits colony formation in AML cell lines and primary patient samples expressing MERTK and/or FLT3-ITD, with a wide therapeutic window compared with that of normal human cord blood cells. Group: Inhibitors. Alternative Names: MRX-2843; MRX 2843; MRX2843; UNC2371; UNC-2371; UNC 2371; UNC2371A; UNC-2371A; UNC 2371A. CAS No. 1429882-07-4. Molecular formula: C29H40N6O. Mole weight: 488.68. Appearance: Solid powder. Purity: >95%. IUPACName: (1r,4r)-4-(2-((2-cyclopropylethyl)amino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol. Canonical SMILES: O[C@H]1CC[C@H] (N2C=C (C3=CC=C (CN4CCN (C)CC4)C=C3)C5=CN=C (NCCC6CC6)N=C52)CC1. Catalog: ACM1429882074. | |
| MS0022 | MS0022 is a SMO antagonist. It showed effective Hh signaling pathway inhibition at the level of SMO in the low nM range, and Hh pathway inhibition downstream of Suppressor of fused (SUFU) in the low μM range. It reduced growth in the tumor cell lines PANC-1, SUIT-2, PC-3 and FEMX in vitro. It is a treatment led to a transient delay of tumor growth that correlated with a reduction of stromal Gli1 levels in SUIT-2 xenografts in vivo. Uses: Ms0022 is a treatment led to a transient delay of tumor growth. Synonyms: MS-0022; MS 0022; MS0022. 2-Bromo-N-(4-(8-methylimidazo[1,2-a]pyridin-2-yl)phenyl)benzamide. Grades: 98%. CAS No. 691392-89-9. Molecular formula: C21H16BrN3O. Mole weight: 406.28. | |
| MS023 | MS023 is a Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. MS023 displayed high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but was completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Synonyms: MS023; MS-023; MS 023. Grades: 98%. CAS No. 1831110-54-3. Molecular formula: C17H25N3O. Mole weight: 287.41. | |
| MS 023 dihydrochloride | MS 023 is a potent and selective type I PRMT inhibitor (IC50= 8, 8, 30, 83 and 119 nM for PRMT6, PRMT8, PRMT1, PRMT4 and PRMT3, respectively). Importantly, MS023 does not inhibit any type II PRMTs (PRMT5 and 9) and type III PRMT (PRMT7) at concentrations up to 10 μM. MS023 displays high potency for type I PRMTs including PRMT1, -3, -4, -6, and -8 but is completely inactive against type II and type III PRMTs, protein lysine methyltransferases and DNA methyltransferases. Synonyms: MS 023 dihydrochloride; MS023 dihydrochloride; MS-023 dihydrochloride; N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride. Grades: ≥98% by HPLC. Molecular formula: C17H25N3O.2HCl. Mole weight: 360.32. | |
| MS023 dihydrochloride | MS023 dihydrochloride is a potent, selective and cell-active human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6 and PRMT8, respectively. Synonyms: N1-Methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-1,2-ethanediamine dihydrochloride; N-{[4-(4-Isopropoxyphenyl)-1H-pyrrol-3-yl]methyl}-N-methyl-1,2-ethanediamine dihydrochloride; 1,2-Ethanediamine, N1-methyl-N1-[[4-[4-(1-methylethoxy)phenyl]-1H-pyrrol-3-yl]methyl]-, hydrochloride (1:2). Grades: ≥95%. CAS No. 1992047-64-9. Molecular formula: C17H27Cl2N3O. Mole weight: 360.32. | |
| MS023 hydrochloride | Cas No. 2108631-19-0. | |
| MS049 | MS049 is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 μM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. Synonyms: MS-049; MS 049; N-Methyl-2-(4-phenylmethoxypiperidin-1-yl)ethanamine. CAS No. 1502816-23-0. Molecular formula: C15H24N2O. Mole weight: 248.36. | |
| MS049 hydrochloride | MS049 is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 μM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. Synonyms: MS049 HCl; MS049 Dihydrochloride; MS-049 hydrochloride; MS 049 hydrochloride; N-methyl-2-(4-phenylmethoxypiperidin-1-yl)ethanamine dihydrochloride. Grades: ≥98%. CAS No. 2095432-59-8. Molecular formula: C15H24N2O·2HCl. Mole weight: 321.3. | |
| MS049 oxalate salt | MS049 oxalate salt is a potent and selective PRMT4 and PRMT6 inhibitor. MS049 has been shown to reduce the H3R2me2a mark in HEK293 cells with an IC50 value of 0.97 μM and also, unexpectedly, to reduce H4R3me2a in HEK293 cells. Synonyms: MS049 oxalate salt; MS 049 oxalate salt; MS-049 oxalate salt; N-Methyl-4-(phenylmethoxy)-1-piperidineethanamine oxalate salt. Grades: ≥98% by HPLC. Molecular formula: C15H24N2O.C2H2O4. Mole weight: 338.4. | |
| MS-073 | MS-073 is a Type II DNA topoisomerase inhibitor under the development of Nihon Schering. MS-073 can overcome MDR in vitro and in vivo compare to verapamil. MS-073 at 0.1 mM can almost completely reverse in vitro resistance to vincristine in vincristine-resistant P388 cells. MS-073 can also reverse in vitro vincristine, adriamycin, etoposide, and actinomycin D resistance in adriamycin-resistant human myelogenous leukemia K562 cells. MS-073 reverses MDR through competitively inhibiting drug binding to P-glycoprotein. Treatment for cancer was discontinued. Uses: Cancer. Synonyms: MS-073; MS073; MS 073; CP-162398; CP-162398; CP 162398; CP162398; 1-(Quinolin-5-yloxy)-3-[4-[(10,11-dihydro-5H-dibenzo[a,d]cyclohepten)-5-yl]piperazin-1-yl]-2-propanol. Grades: 98%. CAS No. 129716-45-6. Molecular formula: C31H33N3O2. Mole weight: 479.62. | |
| MS-1020 | MS-1020 is a selective, cell-permeable inhibitor of Janus kinase 3 (JAK3). It potently inhibited persistently-active STAT3 in a cell type-specific manner, and consistently suppressed interleukin-2-induced JAK3/STAT5 signalling. Synonyms: MS 1020; MS1020; 1-Hydroxy-N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]naphthalene-2-carboxamide. Grades: ≥95%. CAS No. 1255516-86-9. Molecular formula: C21H18N2O3. Mole weight: 346.4. | |
| MS-1020 | Selective JAK3 inhibitor. Blocks STAT signaling. Inducer of apoptosis via down-regulation of anti-apoptotic gene expression. Group: Biochemicals. Alternative Names: 1-Hydroxy-N-(2-(5-hydroxy-1H-indol-3-yl)ethyl)-2-naphthamide. Grades: Highly Purified. CAS No. 1255516-86-9. Pack Sizes: 1mg. Molecular Formula: C21H18N2O3. US Biological Life Sciences. | Worldwide |
| MS15 | MS15 is a potent and selective AKT PROTAC degrader. MS15 inhibits the AKT1, -2, and -3 activities, with IC 50 values of 798 nM, 90 nM, and 544 nM, respectively [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3035638-40-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-151613. | |
| MS 15203 | MS 15203 is a potent and selective GPR171 partial agonist (EC50 = 90 nM; 28% inhibition of forskolin activated adenylyl cyclase activity in rat hypothalamic memebranes). It has also been shown to increases neuronal activity in the paraventricular nucleus, and to ncrease food intake and body weight in mice. Synonyms: MS0015203; MS-0015203; MS 0015203; 5-[(2-Methyl-1-oxo-2-propen-1-yl)amino]-1,3-benzenedicarboxylic acid. Grades: ≥98% by HPLC. CAS No. 73912-52-4. Molecular formula: C12H11NO5. Mole weight: 249.22. | |
Our database is helping our users find suppliers everyday.
