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| Product | Description | |
|---|---|---|
| MD2-IN-1 | MD2-IN-1 is an inhibitor of myeloid differentiation protein 2 (MD2) with a KD of 189 μM for recombinant human MD2 (rhMD2). Synonyms: (2E)-1-(3,4-Dimethoxyphenyl)-3-(3,4,5-Trimethoxyphenyl)Prop-2-En-1-One; MDK7229. Grades: 98%. CAS No. 111797-22-9. Molecular formula: C20H22O6. Mole weight: 358.4. |  |
| MDA 19 | MDA 19 is a potent and selective agonist of human cannabinoid receptor 2 (CB2) , with a K i of 43.3 nM. MDA 19 has antiallodynic effects in a rat model of neuropathic pain and does not affect rat locomotor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1048973-47-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15451. |  |
| MDA-MB Transfection Reagent | Transfection Reagent for MDA-MB Breast Adenocarcinoma Cells. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 1794. |  Nevada, Texas, USA |
| MDBN, p97 Inhibitor (3,4-Methylenedioxy-b-nitrostyrene) | Cell-permeable. An irreversible inhibitor of p97 (IC50 <10uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 1485-00-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| MDC (67 aa) (CCL22) human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. |  |
| mDCBPy | mDCBPy. Group: Organic light-emitting diode (oled) materials. CAS No. 1867199-59-4. Product ID: [3,5-di(carbazol-9-yl)phenyl]-pyridin-4-ylmethanone. Molecular formula: 513.6g/mol. Mole weight: C36H23N3O. C1=CC=C2C (=C1) C3=CC=CC=C3N2C4=CC (=CC (=C4) C (=O) C5=CC=NC=C5) N6C7=CC=CC=C7C8=CC=CC=C86. InChI=1S/C36H23N3O/c40-36 (24-17-19-37-20-18-24)25-21-26 (38-32-13-5-1-9-28 (32)29-10-2-6-14-33 (29)38)23-27 (22-25)39-34-15-7-3-11-30 (34)31-12-4-8-16-35 (31)39/h1-23H. NPPBNNHLNOHWOA-UHFFFAOYSA-N. |  |
| MDC (CCL22) from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| MDCK Transfection Reagent | Transfection Reagent for MDCK Kidney Cells. Optimized transfection protocol provided for transfection of siRNA, DNA, mRNA, and microRNA. Transfection Reagents. Transfection Enhancer. Complex Condenser. Uses: Transfection of DNA, RNA, protein and small molecules. Product ID: 6846. | Nevada, Texas, USA |
| MDH1-IN-1 | MDH1-IN-1 (Compound 5i) is a potent inhibitor of MDH1 with an IC50 of 6.79 ?M. MDH1-IN-1 has the potential for the research of cancer diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2143463-31-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147790. | |
| MDH1-IN-2 | MDH1-IN-2 (Compound 7c) is a selective MDH1 inhibitor, with IC50 values of 2.27 and 27.47 ?M for MDH1 and MDH2, respectively. MDH1-IN-2 can reduce the generation of ROS by inhibiting the conversion of 2-Ketoglutaric acid (HY-W013636) to ?-Hydroxyglutaric acid (HY-113038B) mediated by MDH1, thereby suppressing 2-Ketoglutaric acid (HY-W013636)-induced ferroptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2143463-35-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147791. | |
| MDI-2268 | MDI-2268 is an inhibitor of plasma kallikrein inhibitor 1 (PAI-1). MDI-2268 has good antithrombotic properties and regulates blood coagulation and fibrinolysis process by enhancing fibrinolysis. MDI-2268 can be used in research areas such as deep vein thrombosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1609176-50-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124577. | |
| m-DIC-TRZ-2Ph | m-DIC-TRZ-2Ph. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 11-(4,6-Di(biphenyl-3-yl)-1,3,5-triazin-2-yl)-12-phenyl-11,12-dihydroindolo[2,3-a]carbazole. Product Category: Organic Light Emitting Diode (OLED). CAS No. 2133038-36-3. Molecular formula: C51H33N5. Mole weight: 715.84 g/mol. Product ID: ACM2133038363. Alfa Chemistry ISO 9001:2015 Certified. |  |
| m-Di-tert-pentylbenzene | m-Di-tert-pentylbenzene. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Benzene, 1,3-bis(1,1-dimethylpropyl)-, 1,3-bis(2-methylbutan-2-yl)benzene, 3370-27-2, EINECS 222-145-0, m-Di-tert-amylbenzene, m-Di-tert-pentylbenzene, AC1L2RWL, AC1Q1HHZ, CTK4H1096, AR-1H8257, AG-J-78999, Benzene,m-di-tert-pentyl- (7CI,8CI), Benzene,1,3-bis(1,1-dimethylpropyl)-. Product Category: Heterocyclic Organic Compound. CAS No. 3370-27-2. Molecular formula: C16H26. Mole weight: 218.378 g/mol. Purity: 0.96. IUPACName: 1,3-bis(2-methylbutan-2-yl)benzene. Canonical SMILES: CCC(C)(C)C1=CC(=CC=C1)C(C)(C)CC. ECNumber: 222-145-0. Product ID: ACM3370272. Alfa Chemistry ISO 9001:2015 Certified. | |
| Mdivi 1 | Mdivi 1. Group: Biochemicals. Grades: Purified. CAS No. 338967-87-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Mdivi-1 | Mdivi-1 is a selective dynamin-related protein 1 ( Drp1 ) inhibitor. Mdivi-1 is a mitochondrial division/ mitophagy inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Mitochondrial division inhibitor 1. CAS No. 338967-87-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15886. | |
| Mdivi-1 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| Mdivi-1 | Mdivi-1 Inhibitor. Uses: Scientific use. Product Category: T1907. CAS No. 338967-87-6. |  |
| Mdivi-1 | Mdivi-1 is a selective cell-permeable inhibitor of mitochondrial division DRP1 (dynamin-related GTPase) and mitochondrial division Dynamin I (Dnm1) with IC50 of 1-10 μM. Synonyms: Mdivi-1; Mdivi 1; Mdivi1; Mitochondrial Division Inhibitor 1. Grades: >98%. CAS No. 338967-87-6. Molecular formula: C15H10Cl2N2O2S. Mole weight: 353.22. | |
| MDK19922 | MDK19922, also known as NOD-IN-1 or Compound 4, is a potent mixed inhibitor of nucleotide-binding oligomerization domain (NOD)-like receptors, NOD1 (IC50= 5.74 μM) and NOD2(IC50= 6.45 μM). Synonyms: ethyl 1-tosyl-1H-indole-2-carboxylate; NOD-IN-1, compound 4; MDK19922; MDK 19922; MDK-19922. CAS No. 132819-92-2. Molecular formula: C18H17NO4S. Mole weight: 343.39. | |
| MDK30165 | MDK30165, also known as K-Ras(G12C) Inhibitor 6, is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. This compound has potential therapeutic application for diseases related to Ras signaling. Synonyms: N-(1-(2-(2,4-dichlorophenoxy)acetyl)piperidin-4-yl)-4-mercaptobutanamide; K-Ras(G12C) Inhibitor 6; MDK30165; MDK-30165; MDK 30165. CAS No. 2060530-16-5. Molecular formula: C17H22Cl2N2O3S. Mole weight: 405.33. | |
| MDK34597 | MDK34597 is a PI3K inhibitor. Synonyms: MDK34597; MDK-34597; MDK 34597. PI3K inhibitor. PIK-inhibitors; 3-(8-Morpholin-4-yl-9-oxa-1,5,7-triaza-fluoren-6-yl)-phenylamine; 3-(4-morpholin-4-ylpyrido[2,3]furo[2,4-b]pyrimidin-2-yl)aniline. CAS No. 371934-59-7. Molecular formula: C19H17N5O2. Mole weight: 347.378. | |
| MDK35833 | MDK35833, also called as Oct3/4-inducer-1, is a potent Oct3/4-inducer, which enhances its transcriptional activity in diverse human somatic cells, implying the possible benefit from using this class of compounds in regenerative medicine. Oct3/4 is suggested to promotes neuronal differentiation of ES cells under neurogenesis-inducing conditions. Synonyms: 4-[(4-Fluorophenyl)methoxy]-benzeneacetonitrile; Oct3/4-inducer-1, MDK35833; MDK-35833; MDK 35833. CAS No. 1016535-83-3. Molecular formula: C15H12FNO. Mole weight: 241.26. | |
| MDK74978 | MDK74978 is a multi-kinase inhibitor. Synonyms: N- (2-Hydroxyethyl) -4- (6- (4- (trifluoromethoxy) phenylamino) pyrimidin-4-yl) benzamide; MDK74978; MDK-74978; MDK 74978. Multi-kinase inhibitor I. CAS No. 778274-97-8. Molecular formula: C20H17F3N4O3. Mole weight: 418.376. | |
| MDK-7553 | MDK-7553, also known as CD38 inhibitor 78c and Compound-78c, is a potent CD38 inhibitor. MDK-7553 has CAS#1700637-55-3, which was reported in J Med Chem. 2015 Apr 23;58(8):3548-71. For the convenience of scientific communication, we name it as MDK-7553. The last four digits of CAS# were used for its name. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CD38 inhibitor 78c; Compound-78c; CD38i_78c; 78c; Cluster of Differentiation 38 Inhibitor; MDK-7553; MDK 7553; MDK7553; CD38-IN-78c; CD38 IN-78c; CD38IN-78c; CD38 inhibitor 78c. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1700637-55-3. Molecular formula: C22H27N3O3S. Mole weight: 413.54. Purity: >98%. IUPACName: 4-(((1r,4r)-4-(2-methoxyethoxy)cyclohexyl)amino)-1-methyl-6-(thiazol-5-yl)quinolin-2(1H)-one. Canonical SMILES: O=C1N(C)C2=C(C=C(C3=CN=CS3)C=C2)C(N[C@H]4CC[C@H](OCCOC)CC4)=C1. Product ID: ACM1700637553. Alfa Chemistry ISO 9001:2015 Certified. | |
| MDL 100009 | MDL 100009 is the S-enantiomer of MDL 100151, which is a selective 5-HT2A antagonist. Synonyms: MDL 100009; MDL100009; MDL-100009; (S)-(2,3-Dimethoxyphenyl){1-[2-(4-fluorophenyl)ethyl]-4-piperidinyl}methanol. Grades: 99%. CAS No. 175673-57-1. Molecular formula: C22H28FNO3. Mole weight: 373.46. | |
| MDL 100151 | MDL 100151 is the racemic MDL 100907 and a selective 5-HT2A antagonist. Synonyms: MDL 100151; MDL-100151; MDL100151; (2,3-dimethoxyphenyl)-[1-[2-(4-fluorophenyl)ethyl]piperidin-4-yl]methanol. Grades: 99%. CAS No. 139290-69-0. Molecular formula: C22H28FNO3. Mole weight: 373.46. | |
| MDL 100907 | MDL 100907 is a selective 5-HT2A receptor antagonist with Ki value of 0.36 nM. It shows antipsychotic activity, attenuates impulsivity, and augments antidepressant effects in vivo. Synonyms: Volinanserin; MDL-100907; MDL 100907; MDL100907; (R)-(+)-α-(2,3-Dimethoxyphenyl)-1-[2-(4-fluorophenyl)ethyl]-4-piperinemethanol; Volinanserin. Grades: ≥98% by HPLC. CAS No. 139290-65-6. Molecular formula: C22H28FNO3. Mole weight: 373.46. | |
| MDL 100907 | MDL 100907. Group: Biochemicals. Grades: Purified. CAS No. 139290-65-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL 105519 | MDL 105519 is a potent and selective antagonist of glycine binding to the NMDA receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 161230-88-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15085. | |
| MDL 105519 | MDL 105519, a ligand selective for the glycine binding site of NMDA receptor, was shown that completely inhibited the binding of [3H]glycine to rat brain membranes with a Ki= 10.9±1.4 nM (n= 6). Inhibits [3H]glycine binding to the NMDA receptor with Kd= 3. Synonyms: MDL-105519; MDL 105519; MDL105519; MDL105,519; MDL-105,519; MDL 105,519; 3-[(E)-2-carboxy-2-phenylethenyl]-4,6-dichloro-1H-indole-2-carboxylic acidMDL 105,519Mdl 105519CHEMBL180427(E)-4,6-Dichloro-3-(2-phenyl-2-carboxyethenyl)indole-2-carboxylic acid161230-88-2MDL-105519Lopac-M-216AC1O7G4OM216_SIGMALopac0_000805C1 8H. CAS No. 161230-88-2. Molecular formula: C18H11Cl2NO4. Mole weight: 376.19. | |
| MDL 105,519 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| MDL 11939 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MDL 11939 | MDL 11939 is a selective 5-HT2A receptor antagonist. MDL 11939 has anti-arrhythmic activity in anesthetized dogs following myocardial infarction. Synonyms: Glemanserin; MDL 11,939; Mdl 11939; α-Phenyl-1-(2-phenylethyl)-4-piperidinemethanol. Grades: ≥99% by HPLC. CAS No. 107703-78-6. Molecular formula: C20H25NO. Mole weight: 295.42. | |
| MDL 11,939 | MDL 11,939. Group: Biochemicals. Grades: Purified. CAS No. 107703-78-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL12330A | MDL12330A (RMI12330A) is an adenyl cyclase inhibitor. MDL12330A inhibits the vasopressin action on the short-circuit current (SCC). MDL12330A is also an inhibitor of cAMP phosphodiesterase [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RMI12330A. CAS No. 40297-09-4. Pack Sizes: 5 mg. Product ID: HY-103192. | |
| MDL 12330A hydrochloride | MDL 12330A hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 40297-09-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL 12330A hydrochloride | MDL 12330A is an adenylyl cyclase inhibitor. It can also inhibit cAMP and cGMP phosphodiesterases, and block slow extracellular and store-operated Ca2+ entry into cells. MDL 12330A can be used to investigate the role of the adenylyl cyclase/cAMP signaling pathway. Synonyms: MDL-12330A; MDL 12330A; MDL12330A; MDL-12330-A; MDL 12330 A; (±)-N-[(1R*,2R*)-2-Phenylcyclopentyl]-azacyclotridec-1-en-2-amine hydrochloride. Grades: ≥98% by HPLC. CAS No. 40297-09-4. Molecular formula: C23H36N2.HCl. Mole weight: 377.01. | |
| MDL-12,330A hydrochloride | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| MDL-12,330A, Hydrochloride - CAS 40297-09-4 | Cell-permeable and irreversible inhibitor of adenylate cyclase (IC?? = 250 μM). Group: Fluorescence/luminescence spectroscopy. | |
| MDL 201012 | MDL 201012 is a selective M3 muscarinic receptor antagonist used as an antimuscarinic agent. Uses: Antimuscarinic agent. Synonyms: MDL 201012; MDL201012; MDL-201012; 1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenylhept-5-yn-2-one; 5-Heptyn-2-one,1-cyclobutyl-7-(dimethylamino)-1-hydroxy-1-phenyl-, hydrochloride, (-)-. Grades: 98%. CAS No. 136722-45-7. Molecular formula: C19H25NO2. Mole weight: 299.41. | |
| MDL 28170 | MDL 28170 is a calpain and cathepsin B inhibitor with Ki values of 10 and 25 nM respectively. It shows neuroprotective effects in vivo. MDL 28170 can attenuate depression in myocardial contractile performance which occurs during reperfusion following cardiac ischemia. Synonyms: benzyl N-[(2S)-3-methyl-1-oxo-1-[(1-oxo-3-phenylpropan-2-yl)amino]butan-2-yl]carbamate. Grades: ≥ 95 % by HPLC. CAS No. 88191-84-8. Molecular formula: C22H26N2O4. Mole weight: 382.45. | |
| MDL 28170 | MDL 28170. Group: Biochemicals. Alternative Names: [ (1S) -1-[[ (1-Formyl-2-phenylethyl) amino]carbonyl]-2-methylpropyl]carbamic Acid Phenylmethyl Ester; Calp III; Calpain Inhibitor III. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 25mg. Molecular Formula: C22H26N2O4, Molecular Weight: 382.45. US Biological Life Sciences. | Worldwide |
| MDL 28170 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MDL-28170 | MDL-28170 (Calpain Inhibitor III) is a potent, selective and membrane-permeable cysteine protease inhibitor of calpain that rapidly penetrates the blood-brain barrier following systemic administration [1] [2]. MDL-28170 also block γ-secretase [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Calpain Inhibitor III. CAS No. 88191-84-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18236. | |
| MDL 28170, Z-Val-Phe-CHO, (Carbobenzoxy-valinyl-phenylalaninal, Calpain Inhibitor III) | A potent, cell-permeable, and selective inhibitor of calpain and cathepsin B (Ki values are 10 and 25nm respectively). MDL 28170 does not inhibit trypsin-like serine proteases. Rapidly penetrates the blood-brain barrier following systemic administration and displays neuroprotective effects in vivo. Modulates the formation of Ab formation by inhibiting the formation of intermediate Ab46 and protecting Ab from degradation. Group: Biochemicals. Grades: Highly Purified. CAS No. 88191-84-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL 29913 | MDL 29913 is a selective NK2 tachykinin receptor antagonist which can be used in the treatment of IBS. Synonyms: MDL 29913; MDL29913; MDL-29913; 1,4,7,10,13,16-Hexaazacyclooctadecane, Cyclic Peptide Deriv.; N-(2-Amino-4-methylpentyl)?-N-methyl-L-leucyl-L-glutaminyl-L-tryptophyl-L-phenylalanylglycine (5?1)?-Lactam. Grades: >97%. CAS No. 135721-56-1. Molecular formula: C40H56N8O6. Mole weight: 744.92. | |
| MDL 29,913 | MDL 29,913. Group: Biochemicals. Grades: Purified. CAS No. 135721-56-1. Pack Sizes: 200ug. US Biological Life Sciences. | Worldwide |
| MDL 29951 | MDL 29951. Group: Biochemicals. Alternative Names: 2-Carboxy-4,6-dichloro-1H-Indole-3-propanoic Acid. Grades: Highly Purified. CAS No. 130798-51-5. Pack Sizes: 250mg. Molecular Formula: C12H9Cl2NO4, Molecular Weight: 302.11. US Biological Life Sciences. | Worldwide |
| MDL 29951 | MDL-29951 is a novel glycine antagonist of NMDA receptor activation, with Ki of 0.14 μM for [3H]glycine binding in vitro and in vivo. Synonyms: MDL 29951; MDL-29951; MDL29951; MDL 29,951; MDL-29,951; MDL29,951. CAS No. 130798-51-5. Molecular formula: C12H9Cl2NO4. Mole weight: 302.107. | |
| MDL 72222 | MDL 72222 is a 5-HT3 receptor antagonist. Synonyms: MDL72222; MDL 72222; MDL-72222; Tropanyl 3,5-dichlorobenzoate; Bemesetron; endo-3,5-Dichloro-benzoic Acid 8-Methyl-8-azabicyclo[3.2.1]oct-3-yl Ester. Grades: ≥99% by HPLC. CAS No. 40796-97-2. Molecular formula: C15H17Cl2NO2. Mole weight: 314.21. | |
| MDL 72222 | MDL 72222. Group: Biochemicals. Grades: Purified. CAS No. 40796-97-2. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| MDL-72274 HCl | MDL-72274 is a selective SSAO inhibitor. It is a potent (IC50 = 10(-9) M) inhibitor of both MAO-B and SSAO, with 190-fold lower affinity for MAO-A. MDL-72974 can be used for the treatment of Parkinson diseases. Uses: Parkinson diseases. Synonyms: MDL72274; MDL-72274; MDL 72274; MDL72274A; MDL-72274A; MDL 72274A; MDL72274 HCl; (E)-3-chloro-2-phenylprop-2-en-1-amine hydrochloride. Grades: 98%. CAS No. 85278-24-6. Molecular formula: C9H11Cl2N. Mole weight: 204.09. | |
| MDL 72527 | MDL 72527. Group: Biochemicals. Grades: Purified. CAS No. 93565-01-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL 72527 | MDL 72527 is a polyamine oxidase inhibitor. It can block the production of H2O2 and increase the cells survival. MDL 72527 shows anticancer and neuroprotective activity in vivo. Synonyms: MDL 72527; MDL72527; MDL-72527; N1,N4-Di-2,3-butadienyl-1,4-butanediamine dihydrochloride. Grades: ≥95% by HPLC. CAS No. 93565-01-6. Molecular formula: C12H20N2.2HCl. Mole weight: 265.23. | |
| MDL 72527 | MDL 72527 is a potent polyamine oxidase (PAO) inhibitor. MDL 72527 shows a lysosomotropic effect. MDL 72527 shows neuroprotective effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 93565-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100621. | |
| MDL 72527 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MDL 72832 hydrochloride | MDL 72832 hydrochloride is a potent ligand at 5-HT1A receptors, with mixed agonist and antagonist properties. Synonyms: MDL 72832 hydrochloride; MDL72832 hydrochloride; MDL-72832 hydrochloride; 8-[4-(1,4-Benzodioxan-2-ylmethylamino)butyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride. Grades: ≥99% by HPLC. CAS No. 113777-40-5. Molecular formula: C22H30N2O4.HCl. Mole weight: 422.95. | |
| MDL 72832 hydrochloride | MDL 72832 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 113777-40-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL 73005EF hydrochloride | MDL 73005EF hydrochloride is a 5-HT1A receptor antagonist. Synonyms: MDL 73005EF hydrochloride; MDL73005EF hydrochloride; MDL-73005EF hydrochloride; 8-[2-(1,4-Benzodioxan-2-ylmethylamino)ethyl]-8-azaspiro[4.5]decane-7,9-dione hydrochloride. Grades: ≥98% by HPLC. CAS No. 102908-60-1. Molecular formula: C20H26N2O4.HCl. Mole weight: 394.9. | |
| MDL 73005EF hydrochloride | MDL 73005EF hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 102908-60-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| MDL-860 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| MDM2 Antagonist IV, Nutlin-3a ((-)-4-(4,5-bis-(4-Chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydroimidazole-1-carbonyl)piperazine-2-one) | A cell-permeable and highly potent active enantiomer of Nutlin-3 that binds to the p53-binding pocket and blocks the interaction of p53 and MDM2 (IC50=90nM). Exhibits over 150-fold greater affinity for MDM2 than its less active enantiomer, Nutlin-3b. Induces p53 mediated apoptosis by both transcription-dependent and independent mechanisms. Shown to greatly potentiate the cytotoxic effects of chemotherapeutic agents and reduce tumor burden in vivo. Also shown to overcome ATM-mediated resistance to fludarabine in chronic lymphocyte leukemia. Cells treated with Nutlin-3a permanently lose their ability to proliferate and enter into a pattern of permanent senescence. Mouse embryonic fibroblasts with p53+/+ MEFs show significantly reduced reprogramming capabilities following Nutlin-3a treatment. Group: Biochemicals. Grades: Highly Purified. CAS No. 675576-98-4. Pack Sizes: 5mg. Molecular Formula: C??H??Cl?N?O?. US Biological Life Sciences. | Worldwide |
| MDM2, HIS tagged human | recombinant, expressed in E. coli, ?80% (SDS-PAGE), buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| MDM2 Inhibitor VII, MEL23 | The MDM2 Inhibitor VII controls the biological activity of MDM2. This small molecule/inhibitor is primarily used for Protease Inhibitors applications. Group: Fluorescence/luminescence spectroscopy. | |
| MDM2 Inhibitor VII, MEL23 (3-Butyl-6-hydroxy-5-(2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indol-1-yl)pyrimidine-2,4(1H,3H)-dione, MDM2-MDMX E3 Ligase Inhibitor) | A cell-permeable tetrahydro-b-carbolinylbarbiturate compound that selectively inhibits the E3 ligase activity of Mdm2-MdmX hetero-complex over that of Mdm2-Mdm2 homo-complex (70.6% vs. 17.6% inhibition, respectively, at 100uM), without affecting Mdm2-MdmX complex formation or the activity of two other UbcH5C-utilizing ligase complexes Roc1-Cul1 and BRCA1-BARD1. Effectively inhibits ubiquitination and proteasomal degradation of cellular Mdm2 and p53 (effective conc.=14uM in U2OS, RKO, and HCT116 cultures) and induce RKO and MEF cell death in a p53- and Mdm2-dependent manner. Unlike Nutlin-3, MEL23 does not interfere with Mdm2-p53 interaction. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MDM2/MDMX Dual Inhibitor, RO-5963 ((Z)-2-(4-((6-Chloro-7-methyl-1H-indol-3-yl)methylene)-2,5-dioxoimidazolidin-1-yl)-2-(3,4-difluorophenyl)-N-(1,3-dihydroxypropan-2-yl)acetamide, MDM2 Inhibitor VII, MDMX Inhibitor III) | A cell-permeable indolyl-hydantoin compound that simultaneously inhibits the interaction of both, MDM2 and MDMX with p53 (IC50 = 17.3 and 24.7nM, respectively, in vitro). Releases p53 from MDMX inhibition, stabilizes it, and fully restores its function. Shown to be far more superior to Nutlin-3a in blocking p53 interaction with MDMX. Binds to Phe, Trp, and Leu sub-pockets on the surface of MDMX and MDM2, and promotes MDMX and MDM2 dimer formation. Shown to induce cell cycle arrest in G1 and G2 phases. Also reported to induce apoptosis in several tumor cell lines expressing wild-type p53/MDMX (~10-20uM). Its actions are not believed to be due to any genotoxic stress. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| MDMA (Methylenedioxy-N-methylamphetamine (MDMA) (Ecstacy) (BSA) | Methylenedioxy-N-methylamphetamine (MDMA). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| MDMO-PPV | light-emitting polymer. Group: Oled and pled materials. | |
| MDMO-PPV | MDMO-PPV is a dialkoxy substituted poly(p-phenylenevinylene) (PPV) based conjugating polymer which has long side chains that form flexible films for organic electronics. It is a piezoresistant polymer with HOMO and LUMO orbital positions at 5.4 and 3.4 eV, respectively. MDMO-PPV forms an active layer that can be used in photoconductive and electroluminescent applications. Uses: Mdmo-ppv can also be used in the fabrication of bulk heterojunction solar cells(bhj). Group: Organic field effect transistor (ofet) materials organic light-emitting diode (oled) materials organic solar cell (opv) materials. Alternative Names: Poly[2-methoxy-5-(3',7'-dimethyloctyloxy)-1,4-phenylenevinylene]. CAS No. 177716-59-5. Pack Sizes: 1 g in glass bottle. Product ID: 4-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-1-(4-fluorophenyl)butan-1-one. Molecular formula: Mn ~120,000. Mole weight: C21H23ClFNO2. COc1ccc(OCCC(C)CCCC(C)C)cc1C=C. InChI=1S/C21H23ClFNO2/c22-18-7-5-17 (6-8-18)21 (26)11-14-24 (15-12-21)13-1-2-20 (25)16-3-9-19 (23)10-4-16/h3-10, 26H, 1-2, 11-15H2. LNEPOXFFQSENCJ-UHFFFAOYSA-N. | |
| MDP3FL | MDP3FL. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2,7-Bis{2-[phenyl(m-tolyl)amino]-9,9-dimethyl-fluorene-7-yl}-9,9-dimethyl-fluorene. Product Category: Organic Light Emitting Diode (OLED). CAS No. 239476-24-5. Molecular formula: C71H60N2. Mole weight: 941.25 g/mol. Product ID: ACM239476245. Alfa Chemistry ISO 9001:2015 Certified. | |
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