A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
PD 312237. Group: Biochemicals. Alternative Names: 1-Deoxy-4-O- β-D-galactopyranosyl-1-[(4R)-4-(2-methylpropyl)-2-oxo-1-pyrrolidinyl]- β-D-fructofuranose. Grades: Highly Purified. CAS No. 501666-23-5. Pack Sizes: 1mg. Molecular Formula: C20H35NO11, Molecular Weight: 465.49. US Biological Life Sciences.
Worldwide
PD318088
PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088 can be used for cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 391210-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12062.
PD318088
PD318088. Uses: Designed for use in research and industrial production. Product Category: Bromine Series. CAS No. 391210-00-7. Product ID: ACM391210007. Alfa Chemistry ISO 9001:2015 Certified.
PD-325901, Free Base (PD 0325901, MEK1/2 Inhibitor III)
A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells. PD 325901 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). The potency, solubility and effectiveness of PD 325901 are greatly improved compared to PD 184352 (CI-1040). Group: Biochemicals. Alternative Names: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide; PD 0325901, MEK1/2 Inhibitor III. Grades: Highly Purified. CAS No. 391210-10-9. Pack Sizes: 10mg, 25mg. US Biological Life Sciences.
Worldwide
PD 334581
PD 334581. Group: Biochemicals. Grades: Purified. CAS No. 548756-68-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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PD 404182
PD 404182. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,4-Dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Appearance: Solid. CAS No. 72596-74-8. Molecular formula: C11H11N3S. Mole weight: 217.29. IUPACName: 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Canonical SMILES: C1CN=C2C3=CC=CC=C3SC(=N)N2C1. Product ID: ACM72596748-1. Alfa Chemistry ISO 9001:2015 Certified.
PD 407824
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 622864-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18961.
PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments. Group: Biochemicals. Alternative Names: 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione; PD 0407824. Grades: Highly Purified. CAS No. 622864-54-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PD 81723
PD 81723. Group: Biochemicals. Grades: Purified. CAS No. 132861-87-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PD 90780
PD 90780. Group: Biochemicals. Grades: Purified. CAS No. 77422-99-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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PD98059
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 ?M) and AHR transformation (IC50 of 1 ?M). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 167869-21-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12028.
PD 98059
PD 98059. Group: Biochemicals. Grades: Purified. CAS No. 167869-21-8. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences.
Highly selective, reversible and cell permeable MEK (MAP kinase kinase) inhibitor. Blocks the phosphorylation and activation of the MAP kinase pathway. T cell activation inhibitor. Inhibits cell growth and cell proliferation of several cancer cells. Group: Biochemicals. Alternative Names: 2- (2-Amino-3-methoxyphenyl) -4H-1-benzopyran-4-one; 2- (2-amino-3-methoxyphenyl) oxanaphthalen-4-one; NSC 679828; PD 098059. Grades: Highly Purified. CAS No. 167869-21-8. Pack Sizes: 1mg, 5mg, 10mg, 50mg. Molecular Formula: C??H??NO?, Molecular Weight: 267.3. US Biological Life Sciences.
Worldwide
PD 98059 - CAS 167869-21-8
PD 98059, CAS 167869-21-8, is a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK). Inhibits MAP Kinase activation and subsequent phosphorylation of MAP Kinase substrates. Group: Fluorescence/luminescence spectroscopy.
PDAT
PDAT is a noncompetitive indolethylamine-N-methyltransferase (INMT) inhibitor with a K i of 84 μM for rabbit lung INMT (rabINMT) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1226213-83-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124101.
pdBD-2
pdBD-2 is an antimicrobial peptide found in Chinese loach, Paramisgurnus dabryanus. It has anti-gram-positive bacteria and gram-negative bacteria activity. Synonyms: Paramisgurnus dabryanus beta defensin 2. Grade: >98%.
PDBT-co-TT
PDBT-co-TT. Uses: Designed for use in research and industrial production. Product Category: Flexible Printed Electronics. CAS No. 1260685-65-1. Product ID: ACM1260685651. Alfa Chemistry ISO 9001:2015 Certified.
PDBT-T1
Band gap: 1.93 eV. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. Alternative Names: Poly[[5,10-bis(5-octyl-2-thienyl)dithieno[2,3-d:2',3'-d']benzo[1,2-b:4,5-b']dithiophene-2,7-diyl]-2,5-thiophenediyl[5,7-bis(2-ethylhexyl)-4,8-dioxo-4H,8H-benzo[1,2-c:4,5-c']dithiophene-1,3-diyl]-2,5-thiophenediyl]. CAS No. 1701403-91-9. Mole weight: (C72H78O2S10)n.
PDCD4-IN-1
PDCD4-IN-1(compound 20031600) is a PDCD4 inhibitor with a K d value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 494763-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153383.
PdCl2(Amphos)2 is a catalyst that is more suitable for use in water than organic solvents [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 887919-35-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W010686.
PDD00017272
PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (EC50=4.8 nM) and an activator of PARP1/2. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC50 of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133531.
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-21-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108360.
PDDC
PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models. Uses: Scientific research. Group: Signaling pathways. CAS No. 2232878-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156800.
A cell-permeable pyrazoloquinoline compound that acts as a potent phosphodiesterase 10A inhibitor (Ki≤5nM against human PDE10A), while exhibiting >500-fold selectivity over other human PDEs 1-11 and little activity against CYP3A4 (IC50 >20uM) or a panel of 23 kinases (IC50 >30uM). Reported to be orally available in monkey and rat species and be efficacious in reversing nMDAR antagonist (+)-MK-801-induced hyperactivity in a ratsl (MED = 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences.
A cell permeable, potent, and selective oxime PDE4D inhibitor (IC50=0.67uM) which displays much reduced activities toward other PDE4 isoforms. It is shown to cause a significant 40% increase in extracellular cAMP in the hippocampus of freely moving rats in vivo at 100uM, but has no effect on Ab levels. This compound elicits cognitive enhancement in vivo at the optimum dose of 0.003mg/kg in both mice and rat models, and unlike rolipram, does not cause emesis-like behavior in rodents. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
PDE5A1 active from Mouse, Recombinant
Mouse PDE5A (GenBank Accession No. NM_153422) full length with N-terminal GST-tag, MW=124 kDa, expressed in a Baculovirus infected Sf9 cell expression system. Mouse pde5a (genbank accession no. nm_153422) full length with n-terminal gst-tag, mw=124 kda, expressed in a baculovirus infected sf9 cell expression system. Applications: Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Group: Enzymes. Synonyms: CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A. Purity: > 70% (SDS-PAGE). Phosphodiesterase. Mole weight: mol wt 124 kDa. Storage: -70°C. Form: aqueous solution. Source: Baculovirus infected Sf9 cells. Species: Mouse. CN5N; phosphodiesterase 5A, cGMP-specific; PDE5A1; PDE5A. Cat No: NATE-0528.