A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
PD166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. PD166866 has clear antiproliferative effects. Uses: Protein kinase inhibitors. Synonyms: PD166866; PD-166866; PD 166866. Grades: 98%. CAS No. 192705-79-6. Molecular formula: C20H24N6O3. Mole weight: 396.45.
PD 166866
PD 166866. Group: Biochemicals. Alternative Names: N-[2-Amino-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) . Grades: Highly Purified. CAS No. 192705-79-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C20H24N6O3. US Biological Life Sciences.
Worldwide
PD-166866
A novel potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. An inhibitor of the basic fibroplast growth factor (bFGF). Group: Biochemicals. Alternative Names: N-[2-Amino-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) . Grades: Highly Purified. CAS No. 192705-79-6. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
PD-166866
PD166866 is a selective FGFR1 tyrosine kinase inhibitor with an IC 50 of 52.4 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 192705-79-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101296.
PD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. It is suitable for central and peripheral delivery, and used in studies of penile erection, learning and memory. Synonyms: PD 168077 maleate; PD168077 maleate; PD-168077 maleate; N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate. Grades: ≥99% by HPLC. CAS No. 630117-19-0. Molecular formula: C20H22N4O.C4H4O4. Mole weight: 450.49.
PD 168077 maleate
PD 168077 maleate. Group: Biochemicals. Grades: Purified. CAS No. 630117-19-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PD-168077 maleate
PD-168077 maleate is a selective dopamine D 4 receptor agonist, with a K i of 9 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 630117-19-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-21098A.
A selective D4 dopamine receptor agonist (Ki = 8.7nM, EC50 = 8.3nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D2 and D3 Receptors (Ki = 2.8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 630117-19-0. Pack Sizes: 10mg. US Biological Life Sciences.
PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors. It blocks the elevation of intracellular calcium and release of inositol phosphate induced by NMB in cells expressing NMB receptors. Synonyms: (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide. Grades: ≥95%. CAS No. 204066-82-0. Molecular formula: C31H34N6O4. Mole weight: 554.6.
PD168393
PD168393 is a potent, selective and cell-permeable inhibitor of EGFR tyrosine kinase and ErbB2. PD168393 irreversiblely inactivates EGF receptor ( IC50=0.7 nM) and is inactive against insulin receptor, PDGFR, FGFR and PKC[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 194423-15-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13896.
PD 168393. Group: Biochemicals. Alternative Names: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide. Grades: Highly Purified. CAS No. 194423-15-9. Pack Sizes: 1mg. Molecular Formula: C17H13BrN4O, Molecular Weight: 369.22. US Biological Life Sciences.
Worldwide
PD-168393
PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice. Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; PD168393; PD 168393; PD-168393. CAS No. 194423-15-9. Molecular formula: C17H13BrN4O. Mole weight: 369.222.
PD 168393 - CAS 194423-15-9
A potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC?? = 700 pM). Group: Fluorescence/luminescence spectroscopy.
PD 168568 dihydrochloride
PD 168568 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 210688-56-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PD 168568 dihydrochloride
PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki= 8.8 and 1842 nM at D4 and D2 receptors respectively). Synonyms: PD 168568 dihydrochloride; PD168568 dihydrochloride; PD-168568 dihydrochloride; 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride. Grades: ≥98% by HPLC. CAS No. 210688-56-5. Molecular formula: C22H27N3O.2HCl. Mole weight: 422.39.
PD 169316
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. PD169316 selectively inhibits the kinase activity of the phosphorylated p38 without hindering upstream kinases to phosphorylate p38. PD169316 shows antiviral activity against Enterovirus71. PD169316 shows antiviral activity against Enterovirus71. Uses: Scientific research. Group: Signaling pathways. CAS No. 152121-53-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-10578.
PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. Synonyms: PD-169316; PD 169316; PD169316. Grades: 98.0%. CAS No. 152121-53-4. Molecular formula: C20H13FN4O2. Mole weight: 360.348.
PD 169316 - CAS 152121-53-4
A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC?? = 89 nM). Group: Fluorescence/luminescence spectroscopy.
PD173074
PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. Uses: Differentiation, self-renewal. Synonyms: PD173074; PD 173074; PD-173074. Grades: 0.98. CAS No. 219580-11-7. Molecular formula: C28H41N7O3. Mole weight: 523.682.
PD173074
PD173074 is a potent FGFR1 inhibitor with an IC50 of 25 nM and also inhibits VEGFR2 with an IC50 of 100-200 nM, showing 1000-fold selectivity for FGFR1 over PDGFR and c-Src. Uses: Scientific research. Group: Signaling pathways. CAS No. 219580-11-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10321.
A potent and selective FGFR1 tyrosine kinase inhibitor (IC50 = 21.5nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential. Group: Biochemicals. Alternative Names: PD173074, N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N- (1, 1-dimethylethyl) urea. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 2mg. US Biological Life Sciences.
PD 173212 is a potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM), with selectivity over K+, Na+ and L-type Ca2+ channels. Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. Synonyms: PD-173212; PD 173212; PD173212; N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide. Grades: ≥98% by HPLC. CAS No. 217171-01-2. Molecular formula: C38H53N3O3. Mole weight: 599.85.
PD 173212
PD 173212. Group: Biochemicals. Grades: Purified. CAS No. 217171-01-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PD173952
PD173952 is a tyrosine kinases inhibitor with IC50s of 0.3, 1.7 and 6.6 nM against Lyn, Abl and Csk, respectively. PD173952 is also a potent Myt1 kinase inhibitor with a Ki of 8.1 nM. PD173952 induces apoptosis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 305820-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122113.
PD 173952. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C24H21Cl2N5O2. US Biological Life Sciences.
Worldwide
PD-173952
A Bcr-Abl tyrosine kinase inhibitor used in treatment research for chronic myelegenous leukemia (CML). Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PD173955
PD173955 is an orally active inhibitor of Src (IC50= 22 nM), Yes, Abl, ATP and MAP kinases. PD173955 can effectively prevent the mitotic process and has anticancer activity[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 260415-63-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10395.
PD-173955
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PD173955; PD 173955; PD173955. Product Category: Inhibitors. Appearance: White solid powder. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35. Purity: >98%. IUPACName: 6-(2,6-dichlorophenyl)-8-methyl-2-((3-(methylthio)phenyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one. Canonical SMILES: O=C1C(C2=C(Cl)C=CC=C2Cl)=CC3=CN=C(NC4=CC=CC(SC)=C4)N=C3N1C. Product ID: ACM260415632. Alfa Chemistry ISO 9001:2015 Certified.
PD-173955
PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Synonyms: PD173955; PD 173955; PD-173955. Grades: 0.98. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35.
Pd 174265
Pd 174265. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PD 174265;4-[(3-BROMOPHENYL)AMINO]-6-PROPIONYLAMIDOQUINAZOLINE. Product Category: Heterocyclic Organic Compound. Appearance: Yellow solid. CAS No. 216163-53-0. Molecular formula: C17H15BrN4O. Mole weight: 371.23. Purity: ≥97%. Product ID: ACM216163530. Alfa Chemistry ISO 9001:2015 Certified.
PD 174265
PD 174265 is a cell-permeable, reversible inhibitor of EGFR tyrosine kinase activity with IC50 value of 0.45 nM. Synonyms: 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline; N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide. Grades: ≥98%. CAS No. 216163-53-0. Molecular formula: C17H15BrN4O. Mole weight: 371.2.
PD 174265
PD 174265 is a potent, cell-permeable, reversible, and selective inhibitor of EGFR with an IC 50 of 450 pM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 216163-53-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112411.
PD 174265 - CAS 216163-53-0
A potent, cell-permeable, reversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC?? = 450 pM). Group: Fluorescence/luminescence spectroscopy.
PD176252
PD176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively; PD176252 is also an agonist of N-Formyl peptide receptor1/2 (FPR1/FPR2), with EC50s of 0.31 and 0.66 ?M in HL-60 cells. Uses: Scientific research. Group: Signaling pathways. CAS No. 204067-01-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103286.
PD 176252
PD 176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD 176252 inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Synonyms: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide; PD-176252; PD 176252; PD176252. Grades: ≥98% by HPLC. CAS No. 204067-01-6. Molecular formula: C32H36N6O5. Mole weight: 584.67.
PD 176252
PD 176252. Group: Biochemicals. Grades: Purified. CAS No. 204067-01-6. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PD 176252
PD 176252. CAS No: 204067-01-6
Sarchem Laboratories New Jersey NJ
PD180970
PD180970 is a highly potent and ATP-competitive p210Bcr-Abl kinase inhibitor, with an IC50 of 5 nM for inhibiting the autophosphorylation of p210Bcr-Abl. PD180970 also inhibits Src and KIT kinase with IC50s of 0.8 nM and 50 nM, respectively. PD180970 indcues apoptosis of K562 leukemic cells, and can be used for chronic myelogenous leukemia research[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 287204-45-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-103274.
PD180970
PD180970 is a novel Bcr-Abl inhbiitor. PD180970 inhibited in vivo tyrosine phosphorylation of p210Bcr-Abl (IC50 = 170 nM) and the p210BcrAbl substrates Gab2 and CrkL (IC50 = 80 nM) in human K562 chronic myelogenous leukemic cells. In vitro, PD180970 potently inhibited autophosphorylation of p210Bcr-Abl (IC50 = 5 nM) and the kinase activity of purified recombinant Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death. PD180970 is among the most potent inhibitors of the p210Bcr-Abl tyrosine kinase, which is present in almost all cases of human chronic myelogenous leukemia. PD180970 is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia. Synonyms: PD 180970; PD-180970; PF-1515965; PF 1515965; PF1515965; 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-. Grades: ≥95%. CAS No. 287204-45-9. Molecular formula: C21H15Cl2FN4O. Mole weight: 429.27.
PD184161 is an orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner more effectively than PD098059 or U0126. PD184161 inhibited cell proliferation and induced apoptosis at concentrations of > or = 1.0 microM in a time- and concentration-dependent manner. PD184161 has antitumor effects in HCC in vitro and in vivo that appear to correlate with suppression of MEK activity. PD184161 is unable to suppress MEK activity in HCC xenografts in the long term. Synonyms: PD 184161; PD-184161; 2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide. CAS No. 212631-67-9. Molecular formula: C17H13BrClF2IN2O2. Mole weight: 557.56.
PD 184161
PD 184161. Group: Biochemicals. Alternative Names: 5-Bromo-2-[(2-chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide. Grades: Highly Purified. CAS No. 212631-67-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H13BrClF2IN2O2. US Biological Life Sciences.
PD 184352. Group: Biochemicals. Alternative Names: 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 3, 4-Difluoro-2- (2-chloro-4-iodophenylamino) -N-cyclopropyl methoxybenzamide; CI 1040. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C17H14ClF2IN2O2. US Biological Life Sciences.
Worldwide
PD-184352
An inhibitor of ERK signaling pathway. A MAP kinase inhibitor. Group: Biochemicals. Alternative Names: 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide; 3, 4-Difluoro-2- (2-chloro-4-iodophenylamino) -N-cyclopropyl methoxybenzamide; CI 1040. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 10mg. US Biological Life Sciences.
PD184352 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). Group: Biochemicals. Alternative Names: 2-[(2-Chloro-4-iodophenyl)amino]-N-(cyclopropylmethoxy)-3,4-difluorobenzamide. Grades: Highly Purified. CAS No. 212631-79-3. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
PD 198306
PD 198306. Group: Biochemicals. Grades: Purified. CAS No. 212631-61-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PD 198306
PD 198306, an amino-benzamide compound, is an orally bioavailable and potent inhibitor of MAPK kinase 1/2 (MEK1/2; IC50=8 nM). It inhibits isolated enzyme at a concentration of 8 nM and inhibits MEK activity in synovial fibroblasts at concentrations of 30-100 nM. It is selective for MEK1/2 over ERK, c-Src, PI3Kγ, and cyclin-dependent kinases (IC50s = >1 μM). Synonyms: PD-198306; PD 198306; PD198306; N-(Cyclopropylmethoxy)-3,4,5-trifluoro-2-[(4-iodo-2-methylphenyl)amino]-benzamide. Grades: ≥98% by HPLC. CAS No. 212631-61-3. Molecular formula: C18H16F3IN2O2. Mole weight: 476.23.
PD-1-IN-1
PD-1-IN-1 is an inhibitor of programmed cell dealth-1 (PD-1). Synonyms: CA-170; CA-170; CA-170; AUPM 170; AUPM-170; AUPM170; PD-1-IN-1. (2S,3R)-2-[[(1S)-3-amino-1-[3-[(1R)-1-amino-2-hydroxyethyl]-1,2,4-oxadiazol-5-yl]-3-oxopropyl]carbamoylamino]-3-hydroxybutanoic acid; ZINC616580959. CAS No. 1673534-76-3. Molecular formula: C12H20N6O7. Mole weight: 360.32.
PD-1-IN-17
PD-1-IN-17 is a programmed cell death-1 (PD-1) inhibitor. PD-1-IN-17 was first reported in patent WO2015033301A1, (Compound 12), inhibits 92% splenocyte proliferation at 100 nM. Synonyms: PD1-IN-1. CAS No. 1673560-66-1. Molecular formula: C13H22N6O7. Mole weight: 374.35.
PD-1/PD-L1-IN-14
PD-1/PD-L1-IN-14 (compound 17) is a bifunctional inhibitor of PD-1/PD-L1 interactions, with an IC50 of 27.8 nM. PD-1/PD-L1-IN-14 (compound 17) inhibits PD-1/PD-L1 interactions and promotes dimerization, internalization, and degradation of PD-L1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2499965-12-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-144258.
PD-1/PD-L1-IN-23
PD-1/PD-L1-IN-23 is a potent and orally active inhibitor of PD-1/PD-L1. PD-1/PD-L1-IN-23 is an ester proagent of L7. L7 is a benzo[c][1,2,5]oxadiazole derivative and biologically evaluated as inhibitors of PD-L1. PD-1/PD-L1-IN-23 displays significant antitumor effects in tumor models of syngeneic and PD-L1 humanized mice [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2597056-04-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145774.
PD-1/PD-L1 Inhibitor 1
PD-1/PD-L1 Inhibitor 1, is an inhibitor of the PD-1 /PD-Ll protein/protein interaction. Synonyms: PD1-PDL1 inhibitor 1; PD1-PDL1-IN1; PD-1/PD-L1 inhibitor 1; PD-1/PD-L1 inhibitor 1; (2S) -1-[[2, 6-dimethoxy-4-[ (2-methyl-3-phenylphenyl) methoxy]phenyl]methyl]piperidine-2-carboxylic acidPD1-PDL1 inhibitor 1CHEMBL3582252(S)-1-(2,6-dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid1675201-83-8. CAS No. 1675201-83-8. Molecular formula: C29H33NO5. Mole weight: 475.58.
PD-1/PD-L1 inhibitor 2
The programmed death-1/programmed death-ligand 1 (PD-1/PD-L1) interaction plays a dominant role in the suppression of T cell responses, especially in a tumor microenvironment, protecting tumor cells from lysis. PD-1/PD-L1 inhibitor 2 is reported to prevent the interaction of PD-L1 with PD-1 with an IC50 value of 18 nM. Synonyms: BMS-202; BMS 202; BMS202. Grades: 98%. CAS No. 1675203-84-5. Molecular formula: C25H29N3O3. Mole weight: 419.52.
PD-1/PD-L1 Inhibitor 3
PD-1/PD-L1 Inhibitor 3 is a PD-1/PD-L1 interaction inhibitor with IC50 value of 5.6 nM. Synonyms: Programmed Death-1/Programmed Death-Ligand 1 Inhibitor 3. Grades: ≥97% by HPLC. CAS No. 1629654-95-0. Molecular formula: C89H126N24O18S. Mole weight: 1852.2.
PD 224378
PD 224378. Group: Biochemicals. Alternative Names: (4R)-1-(4-O- β-D-Galactopyranosyl- β-D-glucopyranosyl)-4-(2-methylpropyl)-2-pyrrolidinone. Grades: Highly Purified. CAS No. 501665-88-9. Pack Sizes: 1mg. Molecular Formula: C20H35NO11, Molecular Weight: 465.49. US Biological Life Sciences.
Pd2dba3 (Tris(dibenzylideneacetone)dipalladium(0)). CAS No: 51364-51-3
Sarchem Laboratories New Jersey NJ
PD 312236, PD 312237 Mixture
PD 312236 is a pyranoside lactose conjugate degradation product of pregabalin, a GABA analogue used as an anticonvulsant. Group: Biochemicals. Alternative Names: 1-Deoxy-4-O- β-D-galactopyranosyl-1-[(4S)-4-(2-methylpropyl)-2-oxo-1-pyrrolidinyl]- β-D-fructose, Pyranose / Furanose Mixture. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C??H??NO??, Molecular Weight: 465.49. US Biological Life Sciences.