A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
PD 312237. Group: Biochemicals. Alternative Names: 1-Deoxy-4-O- β-D-galactopyranosyl-1-[(4R)-4-(2-methylpropyl)-2-oxo-1-pyrrolidinyl]- β-D-fructofuranose. Grades: Highly Purified. CAS No. 501666-23-5. Pack Sizes: 1mg. Molecular Formula: C20H35NO11, Molecular Weight: 465.49. US Biological Life Sciences.
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PD318088
PD318088 is a MEK inhibitor. Synonyms: PD318088; PD 318088; PD-318088. CAS No. 391210-00-7. Molecular formula: C16H13BrF3IN2O4. Mole weight: 561.094.
PD318088
PD318088 is a potent, allosteric and non-ATP competitive MEK1/2 inhibitor, an analog of PD184352 (HY-50295). PD318088 binds simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. PD318088 can be used for cancer research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 391210-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12062.
PD318088
PD318088. Uses: Designed for use in research and industrial production. Product Category: Bromine Series. CAS No. 391210-00-7. Product ID: ACM391210007. Alfa Chemistry ISO 9001:2015 Certified.
PD-321852
PD-321852 is a small-molecule Chk1 inhibitor, which potentiates gemcitabine-induced clonogenic death in a panel of pancreatic cancer cell lines and evaluated the relationship between endpoints associated with Chk1 inhibition and chemosensitization. Gemcitabine chemosensitization by minimally toxic concentrations of PD-321852 ranged from minimal (<3-fold change in survival) in Panc1 cells to>30-fold in MiaPaCa2 cells. PD-321852 inhibited Chk1 in all cell lines as evidenced by stabilization of Cdc25A; in combination with gemcitabine, a synergistic loss of Chk1 protein was observed in the more sensitized cell lines. Synonyms: PD0321852; PD321852; 4-(2,6-dichlorophenyl)-9-hydroxy-6-(3-(methylamino)propyl)pyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione. Grades: 98%. CAS No. 622856-21-7. Molecular formula: C24H19Cl2N3O3. Mole weight: 468.33.
PD-325901, Free Base (PD 0325901, MEK1/2 Inhibitor III)
A selective and ATP non-competitive MEK inhibitor that suppresses the phosphorylation of ERK in murine colon 26 tumors (IC50 = 0.33nM). In combination with the GSK-3 inhibitor CHIR99021, prevents cell differentiation and sustains self-renewal of embryonic stem (ES) cells. PD 325901 is an inhibitor of mitogen activated protein kinase kinase (MEK or MAPKK). The potency, solubility and effectiveness of PD 325901 are greatly improved compared to PD 184352 (CI-1040). Group: Biochemicals. Alternative Names: N-[(2R)-2,3-Dihydroxypropoxy]-3,4-difluoro-2[(2-fluoro-4-iodophenyl)amino]-benzamide; PD 0325901, MEK1/2 Inhibitor III. Grades: Highly Purified. CAS No. 391210-10-9. Pack Sizes: 10mg, 25mg. US Biological Life Sciences.
Worldwide
PD 334581
PD 334581. Group: Biochemicals. Grades: Purified. CAS No. 548756-68-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
PD 334581
PD 334581, an analog of PD 184352, is an inhibitor of MEK1 that is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. Synonyms: PD 334581; PD334581; PD-334581; N-[5-[3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl]-1,3,4-oxadiazol-2-yl]-4-morpholineethanamine. Grades: ≥98% by HPLC. CAS No. 548756-68-9. Molecular formula: C20H19F3IN5O2. Mole weight: 545.3.
PD 404182
PD 404182. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3,4-Dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Appearance: Solid. CAS No. 72596-74-8. Molecular formula: C11H11N3S. Mole weight: 217.29. IUPACName: 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Canonical SMILES: C1CN=C2C3=CC=CC=C3SC(=N)N2C1. Product ID: ACM72596748-1. Alfa Chemistry ISO 9001:2015 Certified.
PD 404182
PD 404182 is a high affinity inhibitor of KDO 8-P synthase (Ki = 26 nM), and also inhibits dimethylarginine dimethylaminohydrolase 1 (DDAH1). PD 404182 is a potential antibiotic of gram negative bacteria. Synonyms: PD-404182; PD 404182; PD404182. 3,4-Dihydro-2H,6H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Grades: ≥98% by HPLC. CAS No. 72596-74-8. Molecular formula: C11H11N3S. Mole weight: 217.29.
PD 407824
PD 407824 is a checkpoint kinase Chk1 and WEE1 inhibitor with IC50s of 47 and 97 nM, respectively. PD 407824 is a chemical BMP sensitizer and increases the sensitivity of cells to sub-threshold amounts of BMP4[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 622864-54-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18961.
PD-407824 is a Wee1/Chk1 inhibitor useful as cancer treatments. Group: Biochemicals. Alternative Names: 9-Hydroxy-4-phenylpyrrolo[3,4-c]carbazole-1,3(2H,6H)-dione; PD 0407824. Grades: Highly Purified. CAS No. 622864-54-4. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PD 81723
PD 81723, an aminothiophene derivative, has been shown to act as an allosteric enhancer of the adenosine A1 receptor in brain membranes and thyroid cells, which acts via agonist-dependent and independent mechanisms. Synonyms: (2-Amino-4,5-dimethyl-3-thienyl)-[3-(trifluoromethyl)phenyl]methanone; PD 81723; PD81723; NCGC00025124-01; CPD000468734; SAM001247067; PD-81,723; Methanone. Grades: ≥99% by HPLC. CAS No. 132861-87-1. Molecular formula: C14H12F3NOS. Mole weight: 299.31.
PD 81723
PD 81723. Group: Biochemicals. Grades: Purified. CAS No. 132861-87-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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PD 90780
PD 90780. Group: Biochemicals. Grades: Purified. CAS No. 77422-99-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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PD 90780
PD 90780, a pyrazoloquinazolinone compound, is a nonpeptide inhibitor of NGF binding to p75NTR (IC50 ~ 1 μM in CHO cells), which binds NGF, not p75NTR. Differential activity of PD90780 suggests altered NGF-p75NTR interactions in the presence of TrkA. It may be useful in identifying the region(s) of nerve growth factor involved in binding to the p75 receptor and in clarifying the role of p75 receptor in the actions of the neurotrophins. Synonyms: PD 90780; PD90780; PD-90780; 7-(Benzoylamino)-4,9-dihydro-4-methyl-9-oxo-pyrazolo[5,1-b]quinazoline-2-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 77422-99-2. Molecular formula: C19H14N4O4. Mole weight: 362.34.
PD98059
PD98059 is a potent, selective and cell-permeant inhibitor of MAP kinase kinase. It enhances human embryonic stem cell self-renewal. Synonyms: PD-98059; 2-(2-amino-3-methoxyphenyl)chromen-4-one. Grades: >98%. CAS No. 167869-21-8. Molecular formula: C16H13NO3. Mole weight: 267.284.
PD98059
PD98059 is a potent and selective MEK inhibitor with an IC50 of 5 μM. PD98059 binds to the inactive form of MEK, thereby preventing the activation of MEK1 (IC50 of 2-7 μM) and MEK2 (IC50 of 50 μM) by upstream kinases. PD98059 is a ERK1/2 signaling inhibitor. PD98059 is a ligand for the aryl hydrocarbon receptor (AHR), and suppresses TCDD binding (IC50 of 4 ?M) and AHR transformation (IC50 of 1 ?M). PD98059 also inhibits Mycobacterium bovis Bacillus CalmetteGuerin (BCG)-induced autophagy[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 167869-21-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12028.
PD 98059
PD 98059. Group: Biochemicals. Grades: Purified. CAS No. 167869-21-8. Pack Sizes: 1mg, 10mg, 50mg. US Biological Life Sciences.
Worldwide
PD 98,059
Highly selective, reversible and cell permeable MEK (MAP kinase kinase) inhibitor. Blocks the phosphorylation and activation of the MAP kinase pathway. T cell activation inhibitor. Inhibits cell growth and cell proliferation of several cancer cells. Group: Biochemicals. Alternative Names: 2- (2-Amino-3-methoxyphenyl) -4H-1-benzopyran-4-one; 2- (2-amino-3-methoxyphenyl) oxanaphthalen-4-one; NSC 679828; PD 098059. Grades: Highly Purified. CAS No. 167869-21-8. Pack Sizes: 1mg, 5mg, 10mg, 50mg. Molecular Formula: C??H??NO?, Molecular Weight: 267.3. US Biological Life Sciences.
PD 98059, CAS 167869-21-8, is a cell-permeable, selective & reversible inhibitor of MAP Kinase Kinase (MEK). Inhibits MAP Kinase activation and subsequent phosphorylation of MAP Kinase substrates. Group: Fluorescence/luminescence spectroscopy.
pdAp
pdAp is a remarkable compound product, aiding in research for Parkinson's disease. Demonstrating its potent inhibitory capabilities, it skillfully suppresses the activity of the vital enzyme Dopa decarboxylase, thereby hindering the conversion of levodopa to dopamine. Synonyms: 2'- Deoxyadenosine- 3', 5'- O- bisphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 16174-58-6. Molecular formula: C10H15N5O9P2. Mole weight: 411.2.
PDAT
PDAT is a noncompetitive indolethylamine-N-methyltransferase (INMT) inhibitor with a K i of 84 μM for rabbit lung INMT (rabINMT) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1226213-83-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124101.
pdBD-2
pdBD-2 is an antimicrobial peptide found in Chinese loach, Paramisgurnus dabryanus. It has anti-gram-positive bacteria and gram-negative bacteria activity. Synonyms: Paramisgurnus dabryanus beta defensin 2. Grades: >98%.
PDBT-co-TT
PDBT-co-TT. Uses: Designed for use in research and industrial production. Product Category: Flexible Printed Electronics. CAS No. 1260685-65-1. Product ID: ACM1260685651. Alfa Chemistry ISO 9001:2015 Certified.
PDBT-T1
Band gap: 1.93 eV. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. Alternative Names: Poly[[5,10-bis(5-octyl-2-thienyl)dithieno[2,3-d:2',3'-d']benzo[1,2-b:4,5-b']dithiophene-2,7-diyl]-2,5-thiophenediyl[5,7-bis(2-ethylhexyl)-4,8-dioxo-4H,8H-benzo[1,2-c:4,5-c']dithiophene-1,3-diyl]-2,5-thiophenediyl]. CAS No. 1701403-91-9. Mole weight: (C72H78O2S10)n.
pdC-CE Phosphoramidite
pdC-CE Phosphoramidite is an essential reagent used in the synthesis of nucleic acids for biomedical research. Its high-quality and purity ensure efficient and reliable coupling during solid-phase oligonucleotide synthesis. This phosphoramidite is especially useful for the introduction of phosphodiester bonds in the presence of other modified nucleotides. Ideal for constructing therapeutic oligonucleotides targeting specific diseases. Synonyms: 5'-Dimethoxytrityl-N4-diisobutylaminomethylidene-5-(1-Propynyl)-2'-deoxyCytidine, 3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. CAS No. 193631-87-7. Molecular formula: C51H67N6O7P. Mole weight: 907.1.
PDCD4-IN-1
PDCD4-IN-1(compound 20031600) is a PDCD4 inhibitor with a K d value of 350 nM, which can promote the expression of BDNF in hippocampal neuron cell HT-22 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 494763-64-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153383.
PdCl2(Amphos)2 is a catalyst that is more suitable for use in water than organic solvents [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 887919-35-9. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W010686.
pdCp
The pdCp compound, renowned for its multifarious applications within the biomedical sector, epitomizes indispensability. Its predominant function involves serving as a seminal precursor in synthesizing pharmaceutical drugs, with a special focus on combatting cancer and inflammation-related illnesses. Imbued with the virtue of modulating intricate cellular pathways integral to disease progression, pdCp exhibits tremendous potential for therapeutic advancements. Synonyms: 2'- Deoxycytidine- 3', 5'- O- bisphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 4682-43-3. Molecular formula: C9H15N3O10P2. Mole weight: 387.2.
PDD00017272
PDD00017272 is an inhibitor of poly(ADP-ribose) glycohydrolase (PARG) (EC50=4.8 nM) and an activator of PARP1/2. PDD00017272 inhibits its activity of hydrolyzing poly(ADP-ribose) (pADPr), resulting in the accumulation of pADPr on chromatin, interfering with DNA damage repair and replication processes, and inducing PARP1/2-dependent cytotoxicity. PDD00017272 can be used in cancer models with DNA repair defects (such as BRCA mutations) or resistance to PARP inhibitors. PDD00017272 has a PARG expression level-correlated inhibitory potency with EC50 of 9.2 nM (PARG cells), the tumor cells with lower PARG expression are more sensitive[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-20-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-133531.
PDD 00017273 is a potent and selective poly (ADP ribose) glycohydrolase (PARG) inhibitor (IC50 = 26 nM), with >350-fold selectivity for PARG over a panel of ion channels, enzymes and receptors, including PARP1 and ARH3. PARG has been shown to be involved in the repair of single strand DNA breaks. PDD 00017273 (0.3 μM) also reduces the viability of BRCA1, BRCA2, PALB2, FAM175A, and BARD1 depleted cells. PDD 00017273 stalls replication forks and induces DNA damage that requires homologous recombination (HR) for repair. Synonyms: 1-[(1,3-Dimethyl-1H-pyrazol-5-yl)methyl]-1,2,3,4-tetrahydro-N-(1-methylcyclopropyl)-3-[(2-methyl-5-thiazolyl)methyl]-2,4-dioxo-6-quinazolinesulfonamide. Grades: ≥98% by HPLC. CAS No. 1945950-21-9. Molecular formula: C23H26N6O4S2. Mole weight: 514.62.
PDD 00017273
PDD 00017273 is a potent inhibitor of Poly(ADP-ribose) Glycohydrolase (PARG), with an IC50 of 26 nM, and a KD of 1.45 nM[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1945950-21-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-108360.
PDDC
PDDC is a compound used to inhibit Alzheimer's disease. It is a nSMase2 inhibitor that can inhibit tau-induced nSMase2 activity and ceramide elevation, and slow the spread of tau in mouse models. Uses: Scientific research. Group: Signaling pathways. CAS No. 2232878-43-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156800.
PDDHV
PDDHV is a resiniferatoxin (RTX)-type phorboid vanilloid with capsaicin-like selectivity for the cloned rat vanilloid receptor VR1 (TRPV1). It evoked 45Ca2+-uptake by rat dorsal root ganglion neurons in culture. Synonyms: Phorbol 12,13-didecanoate 20-homovanillate. Grades: ≥99%. CAS No. 179469-40-0. Molecular formula: C49H72O11. Mole weight: 837.1.
A cell-permeable pyrazoloquinoline compound that acts as a potent phosphodiesterase 10A inhibitor (Ki≤5nM against human PDE10A), while exhibiting >500-fold selectivity over other human PDEs 1-11 and little activity against CYP3A4 (IC50 >20uM) or a panel of 23 kinases (IC50 >30uM). Reported to be orally available in monkey and rat species and be efficacious in reversing nMDAR antagonist (+)-MK-801-induced hyperactivity in a ratsl (MED = 10mg/kg p.o.) in vivo. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. Molecular Formula: C??H??ClN?O. US Biological Life Sciences.
PDE1-IN-1 is a potent PDE1 inhibitor and neuroprotective agent. Synonyms: PDE1-IN-1. Grades: >98%. CAS No. 1160521-50-5. Molecular formula: C29H26FN7O. Mole weight: 507.56.
PDE1-IN-2
PDE1-IN-2 is an inhibitor of PDE1 that has IC50 values of 6, 140 and 164 nM for PDE1C, PDE1B and PDE1A, respectvely. Synonyms: PDE1 IN 2; 6-bromo-7-(cyclopentylmethyl)-3-(oxan-4-yl)-[1,2,4]triazolo[4,3-a]pyrazin-8-one. CAS No. 1904611-63-7. Molecular formula: C16H21BrN4O2. Mole weight: 381.27.