A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Peimisine is an alkaloid FR 5 from Fritillaria thunbergii, and an angiotensin converting enzyme inhibitory steroidal alkaloid. It is a commonly used antitussive and expectorant herb in traditional Chinese medicine. Uses: Antitussive; anti-ulcer. Synonyms: Ebeiensine. Grades: >98%. CAS No. 19773-24-1. Molecular formula: C27H41NO3. Mole weight: 427.62.
Pelabresib
Pelabresib (CPI-0610) is a potent, selective, orally active and cell-active BET inhibitor. Pelabresib inhibits BRD4-BD1 with an IC 50 of 39 nM, and with an EC 50 value of 0.18 μM for MYC [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CPI-0610. CAS No. 1380087-89-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12863.
Pelagiomicin A
It is produced by the strain of Pelagiobacter variabilis. It has strong activity against gram-positive bacteria and gram-negative bacteria, but no activity against candida albicans. It's cytotoxic to HeLa cells, BALB3T3 and BALB3T3/H-ras cultured in vivo with IC50 (μg/mL) of 0.04, 0.2 and 0.07, respectively. In vivo it has weak inhibitory effect on leukemia P388. Synonyms: Antibiotic 2088A; 3-Hydroxy-L-valine(6-carboxy-4-methoxy-1-phenazinyl)methylester; L-Valine, 3-hydroxy-, (6-carboxy-4-methoxy-1-phenazinyl)methyl ester; (S)-6-(((2-amino-3-hydroxy-3-methylbutanoyl)oxy)methyl)-9-methoxyphenazine-1-carboxylic acid. Grades: 95%. CAS No. 173485-80-8. Molecular formula: C20H21N3O6. Mole weight: 399.40.
Pelagiomicin B
It is produced by the strain of Pelagiobacter variabilis. Synonyms: Antibiotic 2088B; L-Valine, (6-carboxy-4-methoxy-1-phenazinyl)methyl ester. CAS No. 173485-81-9. Molecular formula: C20H21N3O5. Mole weight: 383.40.
Pelagiomicin C
It is produced by the strain of Pelagiobacter variabilis. It has the activity against gram-positive bacteria and gram-negative bacteria. Synonyms: Antibiotic 2088C; Antibiotic B 4607A; Glycine, (6-carboxy-4-methoxy-1-phenazinyl)methyl ester. CAS No. 173485-82-0. Molecular formula: C17H15N3O5. Mole weight: 341.32.
Pelargonidin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 3-(β-D-Galactopyranosyloxy)-5,7-dihydroxy-2-(4-hydroxyphenyl)-1-benzopyrylium. Product Category: Heterocyclic Organic Compound. CAS No. 34425-22-4. Molecular formula: C21H21ClO10. Mole weight: 468.84. Product ID: ACM34425224. Alfa Chemistry ISO 9001:2015 Certified.
Pelargonidin
Cas No. 134-04-3.
Pelargonidin 3-Galactoside
A galactoside of Pelargonidin. A naturally occurring anthocyanin which was tested for cell proliferation inhibitory activity against human cancer cell lines. Synonyms: 3-(Galactosyloxy)-4',5,7-trihydroxyflavylium Chloride; (2R,3R,5S)-2-[5,7-dihydroxy-2-(4-hydroxyphenyl)chromenylium-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol chloride. CAS No. 34425-22-4. Molecular formula: C21H21ClO10. Mole weight: 468.839.
An impurity of Pelargonidin which is a natural polyphenolic anthocyanidin with significant antioxidant effect. Synonyms: Callistephin Chloride. Grades: > 95%. CAS No. 18466-51-8. Molecular formula: C21H21ClO10. Mole weight: 468.84.
Isolated from the plant Salvia splendens (scarlet sage). Group: Enzymes. Synonyms: malonyl-CoA:anthocyanin 5-glucoside 4'''-O-malonyltransferase; Ss5MaT2. Enzyme Commission Number: EC 2.3.1.214. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2160; pelargonidin 3-O-(6-caffeoylglucoside) 5-O-(6-O-malonylglucoside) 4'''-malonyltransferase; EC 2.3.1.214; malonyl-CoA:anthocyanin 5-glucoside 4'''-O-malonyltransferase; Ss5MaT2. Cat No: EXWM-2160.
Pelargonidin-3-O-rutinoside chloride
Pelargonidin-3-O-rutinoside chloride is an innovative compound with antioxidant attributes, used for studying cardiovascular diseases and cancer. Synonyms: Pelargonidin 3-rutinoside. CAS No. 33978-17-5. Molecular formula: C27H31O14Cl. Mole weight: 614.98.
Pelargonidin chloride is an anthocyanidin and also is a scavenger of nitric oxide radical and has antioxidant activities. Pelargonidin inhibits cell viability and induces cell cycle arrest at sub-G1 phase. Pelargonidin chloride increases the mRNA and protein expression of HO-1, NQO1, Nrf2. Pelargonidin chloride improves Aβ-induced memory and learning impairment [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 134-04-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-W011370.
Pelcitoclax (APG-1252) is a potent Bcl-2/Bcl-xl inhibitor with antineoplastic and pro-apoptotic effects [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APG-1252. CAS No. 1619923-36-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-109185.
PELCO 2 Layers Graphene Oxide TEM Support Films on(Carbon mesh, 5 pieces per box)
PELCO 2 Layers Graphene Oxide TEM Support Films on(Carbon mesh, 5 pieces per box). Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-178. Alfa Chemistry ISO 9001:2015 Certified.
PELCO 2 Layers Graphene Oxide TEM Support Films on Lacey Carbon
Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; Pelle
PELCO 6-8 layers CVD Graphene deposited on TEM Grids Lacey Carbon
Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; Pel
PELCO Single Layer Graphene Oxide TEM Support Film(Carbon mesh, 5 pieces per box)
PELCO Single Layer Graphene Oxide TEM Support Film(Carbon mesh, 5 pieces per box). Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-179. Alfa Chemistry ISO 9001:2015 Certified.
Pelgifatamab
Pelgifatamab (BAY-2315497) is a prostate-specific membrane antigen ( PSMA ) antibody. Pelgifatamab can be covalently linked to a binding moiety of 225 Ac and used for metastatic castration-resistant prostate cancer (mCRPC) research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: BAY-2315497; PSMA-TTC. CAS No. 2414550-93-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9992.
Pelitinib
A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer. Group: Biochemicals. Grades: Highly Purified. CAS No. 257933-82-7. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Pelitinib
Pelitinib (EKB-569;WAY-EKB 569) is an irreversible inhibitor of EGFR with an IC 50 of 38.5 nM; also slightly inhibits Src, MEK/ERK and ErbB2 with IC 50 s of 282, 800, and 1255 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EKB-569; WAY-EKB 569. CAS No. 257933-82-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-32718.
Pelitinib
Pelitinib is a 3-cyanoquinoline pan-ErbB tyrosine kinase inhibitor with potential antineoplastic activity. EKB-569 irreversibly binds covalently to epidermal growth factor receptors (EGFR) ErbB-1, -2 and -4, thereby inhibiting receptor phosphorylation and signal transduction and resulting in apoptosis and suppression of proliferation in tumor cells that overexpress these receptors. Synonyms: EKB 569; EKB-569; EKB569; WAY-EKB 569; WAY-EKB569; WAY-EKB-569; CHEBI:38927; NSC729742; WAY-172569; WAY172569; WAY 172569; D05399; D 05399; D-05399. Grades: >98%. CAS No. 257933-82-7. Molecular formula: C24H23ClFN5O2. Mole weight: 467.929.
Pelitinib-d6
Labeled Pelitinib. A tyrosine kinase inhibitor; it is used to prepare formulation for treating primary or secondary cancer. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Pelitrexol
Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity. Pelitrexol inhibits activity of glycinamide ribonucleotide formyltransferase (GARFT), the first folate-dependent enzyme of the de novo purine synthesis pathway essential for cell proliferation. Enzyme inhibition reduces the purine nucleotides pool required for DNA replication and RNA transcription. As a result, this agent causes cell cycle arrest in S-phase, and ultimately inhibits tumor cell proliferation. Synonyms: AG-2037; AG 2037; AG2037; L-Glutamic acid, N-((5-(2-((6S)-2-amino-1,4,5,6,7,8-hexahydro-4-oxopyrido(2,3-d)pyrimidin-6-yl)ethyl)-4-methyl-2-thienyl)carbonyl)-. Grades: >98%. CAS No. 446022-33-9. Molecular formula: C20H25N5O6S. Mole weight: 463.51.
Pellitorine
Pellitorine is a compound isolated from the roots of Piper nigrum. Pellitorine shows strong cytotoxic activities against HL60 and MCT-7 cell lines. Pellitorine has the potential for the research of cancer diseases [1]. Uses: Scientific research. Group: Natural products. CAS No. 18836-52-7. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N3097.
Pellitorine
Cell-permeable. A natural product isolated from the roots of Piper Nigrum. Shows larvicidal, antimycobacterial and antituberculosis activity. Modulator of the sensory neuron function to induce tingling parethesia. Tingling-inducing agent. Excellent stable model compound for sensory studies. alpha-Glucosidase inhibitor used in diabetes mellitus, cancer, infection and inflammatory research. ACAT (Acyl-CoA cholesteryl acyl transferase) inhibitor. Potential anti-cancer lead compound. Source:Synthetic. Originally isolated from roots of Anacyclus pryrethrum and fruits of Piper nigrum. Group: Biochemicals. Alternative Names: (E,E)-N-(2-Methylpropyl) 2,4-decadienamide, BRN 1725967. Grades: Highly Purified. CAS No. 18836-52-7. Pack Sizes: 1mg, 5mg. Molecular Formula: C14H25NO, Molecular Weight: 223.4. US Biological Life Sciences.
Worldwide
Pelophylaxin-1
Pelophylaxin-1 is an antimicrobial peptide found in Rana fukienensis (Skin secretion, Pelophylax plancyi fukienensis, Fukien gold-striped pond frog), and has antimicrobial activity. Synonyms: Pelophylaxin 1. Grades: >98%. CAS No. 877458-36-1. Molecular formula: C131H232N36O39S2. Mole weight: 2999.62.
Pelophylaxin-2
Pelophylaxin-2 is an antimicrobial peptide found in Rana fukienensis (Skin secretion, Pelophylax plancyi fukienensis, Fukien gold-striped pond frog), and has antimicrobial activity. Synonyms: Pelophylaxin 2. Grades: >98%. CAS No. 877458-37-2. Molecular formula: C133H237N37O37S2. Mole weight: 3010.69.
Pelophylaxin-2GY
Pelophylaxin-2GY is an antimicrobial peptide found in Dark-spotted frogs, Pelophylax nigromaculatus, China, Asia. It has activity against gram-negative bacteria E. coli (MIC 2-4 μM). Synonyms: Pelophylaxin 2GY; Gly-Leu-Leu-Leu-Asp-Thr-Val-Lys-Gly-Ala-Ala-Lys-Asn-Val-Ala-Gly-Ile-Leu-Leu-Asn-Lys-Leu-Lys-Cys-Lys-Met-Thr-Gly-Asp-Cys. Grades: ≥97%.
Pelophylaxin-3
Pelophylaxin-3 is an antimicrobial peptide found in Rana fukienensis (Skin secretion, Pelophylax plancyi fukienensis, Fukien gold-striped pond frog), and has antimicrobial activity. Synonyms: Pelophylaxin 3. Grades: >98%. CAS No. 877458-38-3. Molecular formula: C144H255N39O45S3. Mole weight: 3349.03.
Pelophylaxin-4
Pelophylaxin-4 is an antimicrobial peptide found in Rana fukienensis (Skin secretion, Pelophylax plancyi fukienensis, Fukien gold-striped pond frog), and has antimicrobial activity. Synonyms: Pelophylaxin 4; Ile-Leu-Pro-Phe-Leu-Ala-Gly-Leu-Phe-Ser-Lys-Ile-Leu-NH2. Grades: >98%. CAS No. 877458-39-4. Molecular formula: C73H119N15O14. Mole weight: 1430.82.
Pelovaterin
Pelovaterin is an antimicrobial peptide found in Pelodiscus sinensis (Chinese softshell turtle, Trionyx sinensis), and has antibacterial activity against gram-negative bacteria Pseudomonas aeruginosa (EC50=0.42 μg/mL), Proteus vulgaris (EC50=0.37 μg/mL), Proteus mirabilis (EC50=8.4 μg/mL) and gram-positive bacterium Staphylococcus aureus (EC50=42 μg/mL). Grades: >98%. Molecular formula: C177H281N51O55S6. Mole weight: 4195.85.
Peltatoside
Peltatoside. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PELTATOSIDE;QUERCETIN 3-ARABINOGLUCOSIDE;QUERCETIN-3-O-ARABINOGLUCOSIDE;3-[(6-O-alpha-L-arabinopyranosyl-beta-D-glucopyranosyl)oxy]-2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one;PELTATOSIDE hplc;PELTATOSIDE WITH HPLC;3-[(6-O-α-L-Arabinopyra. Product Category: Heterocyclic Organic Compound. Appearance: Powder. CAS No. 23284-18-6. Molecular formula: C26H28O16. Mole weight: 596.5. Purity: 0.98. IUPACName: 2-(3,4-dihydroxyphenyl)-5,7-dihydroxy-3-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-[[(2S,3R,4S,5S)-3,4,5-trihydroxyoxan-2-yl]oxymethyl]oxan-2-yl]oxychromen-4-one. Canonical SMILES: C1C(C(C(C(O1)OCC2C(C(C(C(O2)OC3=C(OC4=CC(=CC(=C4C3=O)O)O)C5=CC(=C(C=C5)O)O)O)O)O)O)O)O. Product ID: ACM23284186. Alfa Chemistry ISO 9001:2015 Certified.
Pelteobagrin
Pelteobagrin is an antimicrobial peptide isolated from Tachysurus fulvidraco (the skin mucus of Yellow catfish, Pelteobagrus fulvidraco Richardson), and has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: Gly-Lys-Leu-Asn-Leu-Phe-Leu-Ser-Arg-Leu-Glu-Ile-Leu-Lys-Leu-Phe-Val-Gly-Ala-Leu. Grades: ≥95%. CAS No. 1314639-41-2. Molecular formula: C108H182N26O25. Mole weight: 2244.79.
Pelubiprofen is an orally active anti-inflammatory agent that inhibits COX enzyme activity (with IC 50 values of 10.66 and 2.88 μM for COX-1 and COX-2 , respectively). Pelubiprofen has significant anti-inflammatory and analgesic effects [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 69956-77-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12383.
Pemafibrate
Pemafibrate. Uses: For analytical and research use. Group: Impurity standards. CAS No. 848259-27-8. Molecular Formula: C28H30N2O6. Mole Weight: 490.56. Catalog: APB848259278.
Pemafibrate
Pemafibrate is a highly selective PPARα agonist, with an EC 50 of 1 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-K-13675. CAS No. 848259-27-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17618.
Pemafibrate impurity 1
Pemafibrate impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 848260-89-9. Molecular Formula: C24H24N2O4. Mole Weight: 404.47. Catalog: APB848260899.
Pemafibrate (racemate)
Pemafibrate (racemate). Uses: For analytical and research use. Group: Impurity standards. CAS No. 848258-31-1. Molecular Formula: C28H30N2O6. Mole Weight: 490.56. Catalog: APB848258311.
pembrolizumab
Pembrolizumab (formerly MK-3475 and lambrolizumab, trade name Keytruda) is a humanized antibody used in cancer immunotherapy. It targets the programmed cell death 1 (PD-1) receptor. The drug was initially used in treating metastatic melanoma. Synonyms: Anti-PD-1 monoclonal antibody - Merck; Humanised monoclonal IgG4 antibody against PD-1 - Merck; Keytruda; Lambrolizumab; MK-3475; MK 3475; MK3475; SCH-900475; SCH 900475; SCH900475. CAS No. 1374853-91-4.
Pembrolizumab
Pembrolizumab (MK-3475) is a humanized IgG4 antibody inhibiting the programmed cell death 1 ( PD-1 ) receptor, used in cancer immunotherapy. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: MK-3475; Lambrolizumab. CAS No. 1374853-91-4. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P9902.
Pemetrexed. Uses: For analytical and research use. Group: Impurity standards. CAS No. 137281-23-3. Molecular Formula: C20H21N5O6. Mole Weight: 427.42. Catalog: APB137281233.
Pemetrexed
Pemetrexed (LY231514) is an antifolate , the K i values of the pentaglutamate of Pemetrexed (LY231514) are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase ( TS ), dihydrofolate reductase ( DHFR ), and glycinamide ribonucleotide formyltransferase ( GARFT ), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514. CAS No. 137281-23-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-10820.
Pemetrexed-1-methyl ester is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed-1-methyl Ester; Pemetrexed Monomethyl Ester 1; SCHEMBL14331358; 1265908-61-9; (4R)-4-{[4-(2-{2-amino-4-oxo-1H,4H,7H- pyrrolo[2,3-d]pyrimidin-5-yl}ethyl)phenyl]formamido}-5-methoxy-5- oxopentanoate; Pemetrexed Impurity 1; 1265908-63-1. Grades: 98%. CAS No. 1265908-63-1. Molecular formula: C21H23N5O6. Mole weight: 441.44.
Pemetrexed-5-methyl Ester
Pemetrexed-5-methyl ester is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Pemetrexed Monomethyl Ester 2; 1265908-60-8; (2S)-2-[[4-[2-(2-amino-4-oxo-3,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]amino]-5-methoxy-5-oxopentanoic acid; SCHEMBL15078817; (S)-2-(4-(2-(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)-5-methoxy-5-oxopentanoic acid ; Pemetrexed Impurity 2; 1265908-64-2. Grades: 98%. CAS No. 1265908-64-2. Molecular formula: C21H23N5O6. Mole weight: 441.44.
Pemetrexed acid oxo impurity
An impurity of Pemetrexed which was approved by the United States Food and Drug administration in 2004 for the treatment of malignant pleural mesothelioma (MPM) in combination with cisplatin, a platinum-containing chemotherapeutic drug. Synonyms: 4-[2-(2-Amino-4,5,6,7-tetrahydro-4,6-dioxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoic Acid. Grades: > 95%. CAS No. 193265-47-3. Molecular formula: C15H14N4O4. Mole weight: 314.3.
Pemetrexed Alpha-Hydroxy Lactum Isomer II
Pemetrexed alpha-hydroxy lactum isomer II is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: (2R)-2-(4-(2-(2-Amino-5-hydroxy-4,6-dioxo-4,5,6,7-tetrahydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioic Acid. Molecular formula: C20H21N5O8. Mole weight: 459.41.
Pemetrexed-d5 Diethyl Ester
Isotope labelled Pemetrexed-d5 Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: Diethyl 2- (4- (2- (2-Amino-4-oxo-4, 7-dihydro-3H-pyrrolo[2, 3-d]pyrimidin-5-yl) ethyl) benzamido) pentanedioate-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Pemetrexed-d5, Disodium Salt (N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d5 Disodium Salt)
Multitargeted antifolate; inhibits thymidylate synthase as well as other folate dependent enzymes. Antineoplastic. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid-d5 Disodium Salt. Grades: Highly Purified. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
Pemetrexed Diethyl Ester
Pemetrexed Diethyl Ester is an protected intermediate in the synthesis of Pemetrexed (P219500), an multitargeted antifolate that inhibits thymidylate synthase as well as other folate dependent enzymes. Group: Biochemicals. Alternative Names: Diethyl 2- (4- (2- (2-Amino-4-oxo-4, 7-dihydro-3H-pyrrolo[2, 3-d]pyrimidin-5-yl) ethyl) benzamido) pentanedioate. Grades: Highly Purified. CAS No. 146943-43-3. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Pemetrexed Diethyl Ester
Pemetrexed diethyl ester is one of pemetrexed intermediates. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Synonyms: Diethyl 2-(4-(2-(2-Amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate; (S)-Diethyl 2-(4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate; N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid 1,5-diethyl ester. Grades: ≥95%. CAS No. 146943-43-3. Molecular formula: C24H29N5O6. Mole weight: 483.52.
Pemetrexed Dimer Impurity 1
Pemetrexed Dimer Impurity 1 is one of pemetrexed impurities. Pemetrexed binds to and inhibits the enzyme thymidylate synthase (TS) which catalyses the methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP), an essential precursor in DNA synthesis. Molecular formula: C43H46N10O15. Mole weight: 942.88.
Pemetrexed disodium (LY231514 disodium) is an antifolate, the K i s of the pentaglutamate of Pemetrexed disodium are 1.3, 7.2, and 65 nM for inhibits thymidylate synthase (TS), dihydrofolate reductase (DHFR), and glycinamide ribonucleotide formyltransferase (GARFT), respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY231514 disodium. CAS No. 150399-23-8. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 200 mg. Product ID: HY-10820A.
Pemetrexed disodium
Pemetrexed disodium. Group: Biochemicals. Alternative Names: N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic acid sodium salt. Grades: Highly Purified. CAS No. 150399-23-8. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C20H19N5Na2O6. US Biological Life Sciences.
Worldwide
Pemetrexed Disodium
Pemetrexed is a novel antifolate and antimetabolite for TS, DHFR and GARFT with Ki of 1.3 nM, 7.2 nM and 65 nM, respectively. Synonyms: LY231514 disodium; Alimta; Rolazar; Tifolar; L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, sodium salt (1:2); L-Glutamic acid, N-[4-[2-(2-amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-, disodium salt; LY-231514 disodium; LY 231514 disodium; Pemetrexed sodium; sodium (4-(2-(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzoyl)-L-glutamate. Grades: >98%. CAS No. 150399-23-8. Molecular formula: C20H19N5Na2O6. Mole weight: 471.37.
Pemetrexed Disodium
Pemetrexed Disodium. Uses: For analytical and research use. Group: Impurity standards. CAS No. 150399-23-8. Molecular Formula: C20H19N5Na2O6. Mole Weight: 471.38. Catalog: APB150399238.
Pemetrexed disodium EP Impurity A
Pemetrexed disodium EP Impurity A. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 869791-42-4(free base); (sodium (S)-2-(4-(2-(2-amino-1-methyl-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl)benzamido)pentanedioate. CAS No. 2243918-27-4. Molecular Formula: C21H21N5Na2O6. Mole Weight: 485.4. Catalog: APB2243918274.