American Chemical Suppliers
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Product | Description | |
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PD 138142 Quick inquiry Where to buy Suppliers range | PD 138142 is a water soluble Sterol O-acyltransferase inhibitor. Triacylglycerol secretion is decreased in the presence of PD-138142-15. Preclinical development for Hypercholesterolaemia in USA was discontinued. Uses: Hypercholesterolaemia. Synonyms: PD-138142; PD138142; PD 138142; 2,6-diisopropylphenyl (2,6-diisopropylphenoxy)carbonylsulfamate. Grades: 98%. CAS No. 142642-31-7. Molecular formula: C25H35NO5S. Mole weight: 461.62. | |
PD-138312 Quick inquiry Where to buy Suppliers range | PD-138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a difluorophenyl substitution or a cyclopropyl at the 1 positions, respectively. It has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens in vitro activity. It was evaluated for its in vivo potencies against acute systemic infections and pneumococcal in mice pneumonia model. Uses: Pd-138312 has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens. Synonyms: PD-138312; PD138312; PD 138312;7-(3-(2-Aminopropan-2-yl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;7-(3-(1-Amino-1-methylethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Grades: >98%. CAS No. 107334-06-5. Molecular formula: C19H23FN4O3. Mole weight: 374.41. | |
PD 140248 Quick inquiry Where to buy Suppliers range | PD 140248, a fluoronaphthyridine compound, has been found to have potential antibacterial effect especially against gram-positive pathogens. It has not been reported about its development status since 2000. Synonyms: PD-140248; PD140248; PD 140248; 7-(3-(1-Aminoethyl)-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 7-(3-(1-aminoethyl-1-pyrrolidinyl))-1-(2,4-difluorophenyl)-6-fluoro-1,4-d. Grades: 98%. CAS No. 147208-55-7. Molecular formula: C21H19F3N4O3. Mole weight: 432.39. | |
PD-140376 Quick inquiry Where to buy Suppliers range | PD-140376 has been found to be a cholecystokininB/gastrin receptor antagonist that could probably be useful in the study of sorts of gastrointestinal disorders. Synonyms: PD-140376; PD 140376; AC1L52KZ; 3-((4-Aminophenyl)methyl)-N-(alpha-methyl-N-((tricyclo(3.3.1.1)dec-2-yloxy)carbonyl)-D-tryptophyl)-beta-alanine; OR223333. Grades: 98%. CAS No. 149027-97-4. Molecular formula: C33H40N4O5. Mole weight: 572.71. | |
PD 142505-0028 Quick inquiry Where to buy Suppliers range | PD 142505-0028, also know as CI-1017, has been found to be a muscarinic agonist that could exhibit effect against cognition disorder so that was once studied in AD. Synonyms: CI-1017; CI1017; CI 1017; PD-142505-0028; PD42505-0028; PD 142505-0028; CTK4D0956; 1-Azabicyclo[2.2.1]heptan-3-one,O-[3-(3-methoxyphenyl)-2-propyn-1-yl]oxime. Grades: 98%. CAS No. 161774-09-0. Molecular formula: C18H20N2O6. Mole weight: 360.36. | |
PD 144418-d7 Oxalate Quick inquiry Where to buy Suppliers range | PD 144418-d7 Oxalate. Group: Biochemicals. Alternative Names: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine-d7 Oxalate. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H17D7N2O5, Molecular Weight: 379.46. US Biological Life Sciences. | Worldwide |
PD 144418 oxalate Quick inquiry Where to buy Suppliers range | PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other receptors and that sigma 1 site may modulate actions in the CNS. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration, and also attenuates cocaine-induced hyperactivity in mice. Synonyms: PD 144418 oxalate; PD144418 oxalate; PD-144418 oxalate; 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate. Grades: ≥98% by HPLC. CAS No. 154130-99-1. Molecular formula: C18H22N2O.C2H2O4. Mole weight: 372.42. | |
PD 145305 Quick inquiry Where to buy Suppliers range | PD 145305 is an inactive analog of PD 150606, a selective calpain inhibitor. Synonyms: 3-phenyl-2-sulfanylpropanoic acid; Benzylthioglykolsaure. Grades: ≥95%. CAS No. 90536-15-5. Molecular formula: C9H10O2S. Mole weight: 182.2. | |
PD 146176 Quick inquiry Where to buy Suppliers range | PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM), without effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). It is known that PD-146176 acts as a noncompetitive inhibitor towards 15-LO, displaying a Ki=197 nM. Furthermore, PD-146176 reduces monocyte macrophage enrichment of atherosclerotic lesions and development of fibrofoamy and fibrous plaque. Synonyms: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole; PD 146176; PD-146176; PD146176; NSC 168807; NSC-168807; NSC168807. Grades: ≥98% by HPLC. CAS No. 4079-26-9. Molecular formula: C15H11NS. Mole weight: 237.32. | |
PD 146176 Quick inquiry Where to buy Suppliers range | PD 146176. Group: Biochemicals. Grades: Purified. CAS No. 4079-26-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PD 146176 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC), solid. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 4079-26-9. Pack Sizes: 5MG, 25MG. Mole weight: 237.32. Catalog: AP4079269. Assay: ≥98% (HPLC). | |
PD-146176 Quick inquiry Where to buy Suppliers range | PD-146176. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. Pack Sizes: 10MG. Catalog: APS010973. Format: Neat. Shipping: Room Temperature. | |
PD 149163 Quick inquiry Where to buy Suppliers range | PD 149163. Group: Biochemicals. Alternative Names: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine ethyl ester; PF-01472472; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine ethyl ester. Grades: Highly Purified. CAS No. 169528-11-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C42H71N9O6. US Biological Life Sciences. | Worldwide |
PD-149163 Quick inquiry Where to buy Suppliers range | PD-149163. Group: Biochemicals. Alternative Names: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester; PF-01472472; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine Ethyl Ester. Grades: Highly Purified. CAS No. 169528-11-4. Pack Sizes: 10mg. Molecular Formula: C42H71N9O6, Molecular Weight: 798.07. US Biological Life Sciences. | Worldwide |
PD 150606 Quick inquiry Where to buy Suppliers range | PD 150606. Group: Biochemicals. Alternative Names: (2Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic Acid; (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic Acid. Grades: Highly Purified. CAS No. 179528-45-1. Pack Sizes: 10mg. Molecular Formula: C9H7IO2S, Molecular Weight: 306.12. US Biological Life Sciences. | Worldwide |
PD 150606 Quick inquiry Where to buy Suppliers range | PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)). It targets the calcium binding sites of calpain. PD 150606 demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. Synonyms: PD-150606; PD150606. Grades: ≥95% by HPLC. CAS No. 179528-45-1. Molecular formula: C9H7IO2S. Mole weight: 306.12. | |
PD 150,606 (3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid) Quick inquiry Where to buy Suppliers range | Cell permeable and selective calpain inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor. Group: Biochemicals. Alternative Names: 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid. Grades: Highly Purified. CAS No. 426821-41-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PD 150606 - CAS 426821-41-2 Quick inquiry Where to buy Suppliers range | A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2. Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 426821-41-2. Pack Sizes: 5MG. Mole weight: 306.12. Catalog: AP426821412. Assay: ≥95% (HPLC). | |
PD 151746 Quick inquiry Where to buy Suppliers range | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. Synonyms: PD-151746; PD 151746; PD151746. Grades: >98%. CAS No. 179461-52-0. Molecular formula: C11H8FNO2S. Mole weight: 237.25. | |
PD 153035 Quick inquiry Where to buy Suppliers range | 153436-54-5, N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-amine, PD153035, PD-153035, pd 153035, 4-(3-BROMOANILINO)-6,7-DIMETHOXYQUINAZOLINE, SU-5271, NSC-669364, AG-1517, 4-(3-bromophenylamino)-6,7-dimethoxyquinazoline, WHI-P-79, UNII-TC62B68RSL, TC62B68RSL, (3-Bromophenyl)(6,7-dimethoxyquinazolin-4-yl)amine, CHEMBL29197, 4-QUINAZOLINAMINE, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-, 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline, GI 230329A, 4-((3-bromophenyl)amino)-6,7-dimethoxyquinazoline, SR-01000597835, N-(3-BROMOPHENYL)-6,7-DIMETHOXY-4-QUINAZOLINAMINE, Tocris-1037, SCHEMBL9423, AG-1517 HCl, BDBM3032, CHEBI:91076, LSPANGZZENHZNJ-UHFFFAOYSA-, DTXSID80165328, BCP00569, EX-A1235, AG1517, HSCI1_000100, MFCD00934896, s6546, AKOS003676410, BCP9001062, CS-0143, DS-1673, NSC 669364, NCGC00024956-01, NCGC00024956-02, NCGC00024956-04, NCGC00024956-18, NCGC00024956-19, AC-32897, AM808088, HY-14346, FT-0643505, PD 153035(AG-1517), K00043, N-(3-bromophenyl)-6,7-dimethoxyquinazolin-4-, J-009016, J-523873, SR-01000597835-2, BRD-K26603252-001-01-9, Q27163047, PD 153035 - CAS 153436-54-5, PD153035;SU-5271; AG1517; ZM 252868, PD 153035; SU 5271; 4-[(3-Bromophenyl)amino]-6,7-dimethoxyquinazoline. | |
PD-153035 Quick inquiry Where to buy Suppliers range | PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). Uses: Antineoplastic agents. Synonyms: AG 1517; AG1517; AG-1517; NSC 669364; NSC669364; NSC-669364; PD 153035; PD153035; SU 5271; SU5271; SU-5271; WHI-P 79. Grades: >98%. CAS No. 153436-54-5. Molecular formula: C16H14BrN3O2. Mole weight: 360.211. | |
PD153035 HCl Quick inquiry Where to buy Suppliers range | PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. Synonyms: SU5271; SU 5271; AG 1517; AG-1517; SU-5271 (AG1517) HCl; ZM 252868 HCl; ZM-252868 HCl; ZM252868 HCl; PD153035 HCl; PD 153035 HCl; PD-153035 HCl; AG 1517 hydrochloride; AG1517 hydrochloride; AG-1517 hydrochloride. Grades: >98%. CAS No. 183322-45-4. Molecular formula: C16H14BrN3O2.HCl. Mole weight: 396.67. | |
PD 158780 Quick inquiry Where to buy Suppliers range | PD 158780. Group: Biochemicals. Grades: Purified. CAS No. 171179-06-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PD158780 Quick inquiry Where to buy Suppliers range | PD158780 is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity with IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4). Synonyms: PD-158780; PD 158780; PD158780. Grades: >98%. CAS No. 171179-06-9. Molecular formula: C14H12BrN5. Mole weight: 330.18. | |
PD 160170 Quick inquiry Where to buy Suppliers range | PD 160170 is a potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM), which is selective over Y2 and Y5 receptors (Ki > 10 μM). Synonyms: PD 160170; PD160170; PD-160170; 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine. Grades: ≥98% by HPLC. CAS No. 181468-88-2. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
PD 160170 Quick inquiry Where to buy Suppliers range | PD 160170. Group: Biochemicals. Grades: Purified. CAS No. 181468-88-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PD-160725 2-Hydroxyethanesulfonate Quick inquiry Where to buy Suppliers range | PD-160725 2-Hydroxyethane sulfonate. Group: Biochemicals. Alternative Names: 2-Hydroxyethanesulfonic Acid 1,4-Dihydro-6-methyl-7-nitro-5-(1-piperidinylmethyl)-2,3-quinoxalinedione; PD-160725 Isethionate Salt. Grades: Highly Purified. CAS No. 1262769-92-5. Pack Sizes: 10mg. Molecular Formula: C17H24N4O8S, Molecular Weight: 444.46. US Biological Life Sciences. | Worldwide |
PD 161570 Quick inquiry Where to buy Suppliers range | PD 161570. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H35Cl2N7O. US Biological Life Sciences. | Worldwide |
PD-161570 Quick inquiry Where to buy Suppliers range | A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PD-161570 Quick inquiry Where to buy Suppliers range | PD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. In addintion, PD-161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro. Synonyms: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; PD-161570; PD 161570; PD161570. CAS No. 192705-80-9. Molecular formula: C26H35Cl2N7O. Mole weight: 532.51. | |
PD-161989 2-Hydroxyethanesulfonate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. CAS No. 186268-07-5 (free base). Pack Sizes: 5MG, 25MG. Mole weight: 430.43. Catalog: ALP186268075. Assay: ≥98% (HPLC). | |
PD-161989 2-Hydroxyethanesulfonate Quick inquiry Where to buy Suppliers range | PD-161989 2-Hydroxyethane sulfonate. Group: Biochemicals. Alternative Names: 2-Hydroxyethanesulfonic Acid 1,4-Dihydro-6-methyl-7-nitro-5-(1-pyrrolidinylmethyl)-2,3-quinoxalinedione. Grades: Highly Purified. CAS No. 1262770-05-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PD 166285 Quick inquiry Where to buy Suppliers range | PD 166285. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H29Cl4N5O2. US Biological Life Sciences. | Worldwide |
PD-166285 Quick inquiry Where to buy Suppliers range | A broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PD-166285-d4 Quick inquiry Where to buy Suppliers range | A labeled broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy-d4]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PD 166285 dihydrochloride Quick inquiry Where to buy Suppliers range | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. Synonyms: PD 166285 dihydrochloride; PD166285 dihydrochloride; PD-166285 dihydrochloride6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 212391-63-4. Molecular formula: C26H27Cl2N5O2.2HCl. Mole weight: 585.35. | |
PD166326 Quick inquiry Where to buy Suppliers range | PD166326 is one of the most potent members of the pyridopyrimidine class of protein tyrosine kinase inhibitors. In mice with the CML-like disease, PD166326 rapidly inhibited Bcr/Abl kinase activity after a single oral dose and demonstrated marked antileukemic activity in vivo. In vivo, PD166326 was also superior to imatinib mesylate in inhibiting the constitutive tyrosine phosphorylation of numerous leukemia-cell proteins, including the src family member Lyn. PD166326 also prolonged the survival of mice with imatinib mesylate-resistant CML induced by the Bcr/Abl mutants P210/H396P and P210/M351T. Synonyms: PD-166326; PD 166326; 6-(2,6-Dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 185039-91-2. Molecular formula: C21H16Cl2N4O2. Mole weight: 427.28. | |
PD 166793 Quick inquiry Where to buy Suppliers range | PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. Synonyms: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine; PD-166793; PD 166793; PD166793; PD-166793-0000. Grades: ≥99% by HPLC. CAS No. 199850-67-4. Molecular formula: C17H18BrNO4S. Mole weight: 412.3. | |
PD 166793 Quick inquiry Where to buy Suppliers range | PD 166793. Group: Biochemicals. Alternative Names: PD 166793-0000; N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-Valine. Grades: Highly Purified. CAS No. 199850-67-4. Pack Sizes: 10mg. Molecular Formula: C17H18BrNO4S, Molecular Weight: 412.3. US Biological Life Sciences. | Worldwide |
PD166793 hydrate Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy. Pack Sizes: 5MG, 25MG. Mole weight: 412.30 (anhydrous basis). Catalog: IAR4241785. Assay: ≥98% (HPLC). | |
PD 166866 Quick inquiry Where to buy Suppliers range | PD 166866. Group: Biochemicals. Alternative Names: N-[2-Amino-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) . Grades: Highly Purified. CAS No. 192705-79-6. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C20H24N6O3. US Biological Life Sciences. | Worldwide |
PD-166866 Quick inquiry Where to buy Suppliers range | A novel potent ATP competitive pyrido[2,3-d]pyrimidine tyrosine kinase inhibitors. An inhibitor of the basic fibroplast growth factor (bFGF). Group: Biochemicals. Alternative Names: N-[2-Amino-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) . Grades: Highly Purified. CAS No. 192705-79-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PD-166866 Quick inquiry Where to buy Suppliers range | ≥98% (HPLC). Uses: For analytical and research use. Group: Fluorescence/Luminescence Spectroscopy; Pharmaceutical Toxicology. CAS No. 192705-79-6. Pack Sizes: 5MG. IUPAC Name: 1-[2-amino-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-3-tert-butylurea. Molecular formula: C20H24N6O3. Mole weight: 396.44. Catalog: APS192705796. Assay: ≥98% (HPLC). SMILES: COc1cc (OC)cc (c1)c2cc3cnc (N)nc3nc2NC (=O)NC (C) (C)C. Format: Neat. Shipping: Room Temperature. | |
PD166866 Quick inquiry Where to buy Suppliers range | PD166866 is a selective inhibitor of the FGF-1 receptor tyrosine kinase (FGFR1) with IC50 = 55 nM, and no effect on c-Src, PDGFR-b, EGFR or insulin receptor tyrosine kinases or MEK, PKC, and CDK4. PD166866 has clear antiproliferative effects. Uses: Protein kinase inhibitors. Synonyms: PD166866; PD-166866; PD 166866. Grades: 98%. CAS No. 192705-79-6. Molecular formula: C20H24N6O3. Mole weight: 396.45. | |
PD 168077 maleate Quick inquiry Where to buy Suppliers range | PD 168077 maleate is a potent D4 dopamine receptor agonist (Ki = 8.7 nM) with > 400-fold selectivity over D2 and > 300-fold selectivity versus D3 subtypes respectively. It is suitable for central and peripheral delivery, and used in studies of penile erection, learning and memory. Synonyms: PD 168077 maleate; PD168077 maleate; PD-168077 maleate; N-(Methyl-4-(2-cyanophenyl)piperazinyl-3-methylbenzamide maleate. Grades: ≥99% by HPLC. CAS No. 630117-19-0. Molecular formula: C20H22N4O.C4H4O4. Mole weight: 450.49. | |
PD 168077 maleate Quick inquiry Where to buy Suppliers range | PD 168077 maleate. Group: Biochemicals. Grades: Purified. CAS No. 630117-19-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PD 168077 Maleate (D4 Dopamine Receptor Agonist, PD 168077 Maleate, PD168077, PD-168077) Quick inquiry Where to buy Suppliers range | A selective D4 dopamine receptor agonist (Ki = 8.7nM, EC50 = 8.3nM). Suitable for central and peripheral delivery. Used in studies of penile erection, learning and memory. Exibits some binding affinity towards human D2 and D3 Receptors (Ki = 2.8uM). Group: Biochemicals. Grades: Highly Purified. CAS No. 630117-19-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PD 168368 Quick inquiry Where to buy Suppliers range | PD 168368 is a competitive antagonist of neuromedin B (NMB) receptors. It blocks the elevation of intracellular calcium and release of inositol phosphate induced by NMB in cells expressing NMB receptors. Synonyms: (2S)-3-(1H-indol-3-yl)-2-methyl-2-[(4-nitrophenyl)carbamoylamino]-N-[(1-pyridin-2-ylcyclohexyl)methyl]propanamide. Grades: ≥95%. CAS No. 204066-82-0. Molecular formula: C31H34N6O4. Mole weight: 554.6. | |
PD 168393 Quick inquiry Where to buy Suppliers range | PD 168393. Group: Biochemicals. Alternative Names: N-[4-[(3-Bromophenyl)amino]-6-quinazolinyl]-2-propenamide. Grades: Highly Purified. CAS No. 194423-15-9. Pack Sizes: 1mg. Molecular Formula: C17H13BrN4O, Molecular Weight: 369.22. US Biological Life Sciences. | Worldwide |
PD-168393 Quick inquiry Where to buy Suppliers range | PD-168393 is a potent, cell-permeable, irreversible, ATP-competitive and selective inhibitor of EGF receptor (EGFR) tyrosine kinase activity (IC50 = 700 pM). It is effective in vivo, suppressing the growth of human epidermoid carcinoma xenografts in mice. Synonyms: 4-[(3-Bromophenyl)amino]-6-acrylamidoquinazoline; PD168393; PD 168393; PD-168393. CAS No. 194423-15-9. Molecular formula: C17H13BrN4O. Mole weight: 369.222. | |
PD 168568 dihydrochloride Quick inquiry Where to buy Suppliers range | PD 168568 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 210688-56-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
PD 168568 dihydrochloride Quick inquiry Where to buy Suppliers range | PD 168568 dihydrochloride is a potent and selective dopamine D4 receptor antagonist (Ki= 8.8 and 1842 nM at D4 and D2 receptors respectively). Synonyms: PD 168568 dihydrochloride; PD168568 dihydrochloride; PD-168568 dihydrochloride; 3-[2-[4-(3,4-dimethylphenyl)-1-piperazinyl]ethyl]-2,3-dihydro-1H-isoindol-1-one dihydrochloride. Grades: ≥98% by HPLC. CAS No. 210688-56-5. Molecular formula: C22H27N3O.2HCl. Mole weight: 422.39. | |
PD 169316 Quick inquiry Where to buy Suppliers range | PD 169316 is a potent, cell-permeable and selective p38 MAP kinase inhibitor, with IC50 of 89 nM. Synonyms: PD-169316; PD 169316; PD169316. Grades: 98.0%. CAS No. 152121-53-4. Molecular formula: C20H13FN4O2. Mole weight: 360.348. | |
PD-173074 Quick inquiry Where to buy Suppliers range | PD 173074. Group: Biochemicals. Alternative Names: N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; PD 173074. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
PD173074 Quick inquiry Where to buy Suppliers range | PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay. These findings elucidated the effectiveness of molecular targeted approach for bladder UC harboring FGFR3 mutations and the potential utility to decrease the intravesical recurrence of nonmuscle invasive bladder UC after transurethral surgical resection. Uses: Differentiation, self-renewal. Synonyms: PD173074; PD 173074; PD-173074. Grades: 0.98. CAS No. 219580-11-7. Molecular formula: C28H41N7O3. Mole weight: 523.682. | |
PD-173074-d9 Quick inquiry Where to buy Suppliers range | Labeled PD 173074. Group: Biochemicals. Alternative Names: N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl-d9) urea. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
PD 173074 (N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N- (1, 1-dimethylethyl) urea Quick inquiry Where to buy Suppliers range | A potent and selective FGFR1 tyrosine kinase inhibitor (IC50 = 21.5nM). Blocking of the FGFR signaling pathway by PD 173074 leads to self-renewal of stem cells via ERK1/2 activation. Treatment of FGF2-expressing human multipotent adipose-derived stem cells with PD173074 decreases dramatically their clonogenicity and differentiation potential. Group: Biochemicals. Alternative Names: PD173074, N-[2-[[4- (Diethylamino) butyl]amino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]-N- (1, 1-dimethylethyl) urea. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 2mg. US Biological Life Sciences. | Worldwide |
PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor) Quick inquiry Where to buy Suppliers range | PD 173074 (PD173074, UNII-A4TLL8634Y, FGF/VEGF Receptor Tyrosine Kinase Inhibitor). Group: Biochemicals. Alternative Names: 1-tert-butyl-3-[2-[4- (diethylamino) butylamino]-6- (3, 5-dimethoxyphenyl) pyrido[2, 3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 219580-11-7. Pack Sizes: 25mg. Molecular Formula: C28 H41 N7O3 , Molecular Weight: 523.7. US Biological Life Sciences. | Worldwide |
PD 173212 Quick inquiry Where to buy Suppliers range | PD 173212 is a potent N-type voltage-gated calcium channel blocker (IC50 = 36 nM), with selectivity over K+, Na+ and L-type Ca2+ channels. Selective N-type voltage sensitive calcium channel (VSCC) blockers have shown efficacy in several animal models of stroke and pain. Synonyms: PD-173212; PD 173212; PD173212; N-[[4-(1,1-Dimethylethyl)phenyl]methyl-N-methyl-L-leucyl-N-(1,1-dimethylethyl)-O-phenylmethyl)-L-tyrosinamide. Grades: ≥98% by HPLC. CAS No. 217171-01-2. Molecular formula: C38H53N3O3. Mole weight: 599.85. | |
PD 173212 Quick inquiry Where to buy Suppliers range | PD 173212. Group: Biochemicals. Grades: Purified. CAS No. 217171-01-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PD 173952 Quick inquiry Where to buy Suppliers range | PD 173952. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C24H21Cl2N5O2. US Biological Life Sciences. | Worldwide |
PD-173952 Quick inquiry Where to buy Suppliers range | A Bcr-Abl tyrosine kinase inhibitor used in treatment research for chronic myelegenous leukemia (CML). Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -8-methyl-2-[[4- (4-morpholinyl) phenyl]amino]pyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 305820-75-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PD-173952 Quick inquiry Where to buy Suppliers range | PD-173952. Uses: For analytical and research use. Group: Enzyme Activators, Inhibitors & Substrates. CAS No. 305820-75-1. IUPAC Name: 6-(2,6-dichlorophenyl)-8-methyl-2-(4-morpholin-4-ylanilino)pyrido[2,3-d]pyrimidin-7-one. Molecular formula: C24H21Cl2N5O2. Mole weight: 482.36. Catalog: APS305820751. SMILES: CN1C (=O)C (=Cc2cnc (Nc3ccc (cc3)N4CCOCC4)nc12)c5c (Cl)cccc5Cl. Format: Neat. | |
PD-173955 Quick inquiry Where to buy Suppliers range | PD-173955 is a src tyrosine kinase inhibitor. PD173955 inhibited Bcr-Abl-dependent cell growth. PD173955 showed cell cycle arrest in G(1). PD173955 has an IC(50) of 1-2 nM in kinase inhibition assays of Bcr-Abl, and in cellular growth assays it inhibits Bcr-Abl-dependent substrate tyrosine phosphorylation. PD173955 inhibited kit ligand-dependent c-kit autophosphorylation (IC(50) = approximately 25 nM) and kit ligand-dependent proliferation of M07e cells (IC(50) = 40 nM) but had a lesser effect on interleukin 3-dependent (IC(50) = 250 nM) or granulocyte macrophage colony-stimulating factor (IC(50) = 1 microM)-dependent cell growth. Synonyms: PD173955; PD 173955; PD-173955. Grades: 0.98. CAS No. 260415-63-2. Molecular formula: C21H16Cl2N4OS. Mole weight: 443.35. | |
PD 174265 Quick inquiry Where to buy Suppliers range | PD 174265 is a cell-permeable, reversible inhibitor of EGFR tyrosine kinase activity with IC50 value of 0.45 nM. Synonyms: 4-[(3-Bromophenyl)amino]-6-propionylamidoquinazoline; N-[4-(3-bromoanilino)quinazolin-6-yl]propanamide. Grades: ≥98%. CAS No. 216163-53-0. Molecular formula: C17H15BrN4O. Mole weight: 371.2. | |
PD 176252 Quick inquiry Where to buy Suppliers range | PD 176252 is a potent antagonist of neuromedin-B preferring (BB1) and gastrin-releasing peptide-preferring (BB2) receptor with Kis of 0.17 nM and 1 nM for human BB1 and BB2 receptors, and 0.66 nM, 16 nM for Rat BB1 and BB2 receptors, respectively. PD 176252 inhibits proliferation of rat C6 glioma cells (IC50 = 2 μM) and inhibits NCI-H1299 xenograft proliferation in nude mice (IC50 = 5 μM). Synonyms: (S)-N-[[1-(5-Methoxy-2-pyridinyl)cyclohexyl]methyl]-α-methyl-α-[[[-(4-nitrophenyl)amino]carbonyl]amino-1H-indole-3-propanamide; PD-176252; PD 176252; PD176252. Grades: ≥98% by HPLC. CAS No. 204067-01-6. Molecular formula: C32H36N6O5. Mole weight: 584.67. | |
PD 176252 Quick inquiry Where to buy Suppliers range | PD 176252. CAS No: 204067-01-6 | Sarchem Laboratories New Jersey NJ |
PD 176252 Quick inquiry Where to buy Suppliers range | PD 176252. Group: Biochemicals. Grades: Purified. CAS No. 204067-01-6. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
PD 176252 Quick inquiry Where to buy Suppliers range | Pharmaceutical/ API Drug Impurities/ Metabolites; Research Application. CAS No. 204067-01-6. | |
PD180970 Quick inquiry Where to buy Suppliers range | PD180970 is a novel Bcr-Abl inhbiitor. PD180970 inhibited in vivo tyrosine phosphorylation of p210Bcr-Abl (IC50 = 170 nM) and the p210BcrAbl substrates Gab2 and CrkL (IC50 = 80 nM) in human K562 chronic myelogenous leukemic cells. In vitro, PD180970 potently inhibited autophosphorylation of p210Bcr-Abl (IC50 = 5 nM) and the kinase activity of purified recombinant Abl tyrosine kinase (IC50 = 2.2 nM). Incubation of K562 cells with PD180970 resulted in cell death. PD180970 is among the most potent inhibitors of the p210Bcr-Abl tyrosine kinase, which is present in almost all cases of human chronic myelogenous leukemia. PD180970 is a promising candidate as a novel therapeutic agent for Bcr-Abl-positive leukemia. Synonyms: PD 180970; PD-180970; PF-1515965; PF 1515965; PF1515965; 6-(2,6-Dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one; Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(2,6-dichlorophenyl)-2-[(4-fluoro-3-methylphenyl)amino]-8-methyl-. Grades: ≥95%. CAS No. 287204-45-9. Molecular formula: C21H15Cl2FN4O. Mole weight: 429.27. |