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| Product | Description | |
|---|---|---|
| PD 128907 | PD 128907 is a selective D2 and D3 dopamine receptor agonist that can be used as an antipsychotic. Uses: Antipsychotic. Synonyms: PD 128907; PD128907; PD-128907; 4-propyl-3,4a,5,10b-tetrahydro-2H-chromeno[4,3-b][1,4]oxazin-9-ol; 2H,5H-[1]Benzopyrano[4,3-b]-1,4-oxazin-9-ol,3,4,4a,10b-tetrahydro-4-propyl-, (4aS,10bS)-rel-; 3,4,4a,10b-Tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol. Grades: 99%. CAS No. 123594-64-9. Molecular formula: C14H19NO3. Mole weight: 249.31. |  |
| PD128907 HCl | PD 128907 HCl is a potent and selective dopamine D3 receptor agonist, with EC50 of 0.64 nM, exhibits 53-fold selectivity over dopamine D2 receptor. Synonyms: PD 128907 HCl; PD-128907 HCl. Grades: >98%. CAS No. 112960-16-4. Molecular formula: C14H20ClNO3. Mole weight: 285.77. | |
| PD 128907 hydrochloride | PD 128907 (hydrochloride) is a biochemical reagent that can be used as a biological material or organic compound for life science related research. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 112960-16-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100539A. |  |
| PD 130883 | This active molecular is a potent lipophilic quinazoline antifolate and data show that marked PD130883 suppression of thymidylate synthase slows the rate but not the extent of tetrahydrofolate cofactor interconversion to dihydrofolate upon complete suppression of dihydrofolate reductase with trimetrexate. Synonyms: CHEMBL62769;123685-36-9;2-Amino-6-(((4-nitrophenyl)-2-propynylamino)methyl)-4(3H)quinazolinone;4(3H)-Quinazolinone,2-amino-6-[[(4-nitrophenyl)-2-propyn-1-ylamino]methyl]-;ACMC-20mqpf;PD-130883; PD130883; PD 130883. Grades: 95%. CAS No. 123685-36-9. Molecular formula: C18H15N5O3. Mole weight: 349.34. | |
| PD 130908 | PD 130908 is an effective hypoxic cytotoxin as an analogue of RSU 1069, but less potent than the hypoxic cell radiosensitizer RSU 1069. Toxicity toward hypoxic tumor cells in vivo is demonstrated by clamping tumors (for 60 min) following administration of PD 130908. No development was reported for the treatment of cancer. Uses: Cancer. Synonyms: PD-130908; PD130908; PD 130908; N-(2-bromoethyl)-3-(2-nitro-1H-imidazol-1-yl)propan-1-amine hydrobromide. Grades: 98%. CAS No. 131505-02-7. Molecular formula: C8H14Br2N4O2. Mole weight: 358.03. | |
| PD 131628 | PD 131628 is a new fluoroquinolone as the bioactive form of PD 131112 which is a antibacterial agent originated by Pfizer. PD 131112 can be used for the treatment of infections with penicillin-resistant and -susceptible pneumococci, but no development has been published yet. Uses: Bacterial infections. Synonyms: PD-131628; PD131628; PD 131628; (S)-7-(3-aminopyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid. Grades: 98%. CAS No. 127967-03-7. Molecular formula: C16H17FN4O3. Mole weight: 332.33. | |
| PD 132002 | PD 132002 is a renin inhibitor originated by Pfizer. In Dec 2001, clinical trials for Hypertension in USA was discontinued. Uses: Hypertension. Synonyms: PD-132002; PD132002; PD 132002; (2R)-methyl 3-amino-2-((2S)-N-((2S,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)-3-oxopropanoate. Grades: 98%. CAS No. 134452-04-3. Molecular formula: C31H50N4O9S. Mole weight: 654.81. | |
| PD 134922 | PD 134922 has been found to be a HIV-1 protease inhibitor that could probably be effective against HIV infections. Synonyms: PD-134922; PD134922; PD 134922; AC1L3V1C; DTXSID30164523; AM008268; (2S,4S,5S)-N-butyl-6-cyclohexyl-4-hydroxy-5-[[(2S)-2-[[(2S)-2-(morpholin-4-ylsulfonylamino)-3-phenylpropanoyl]amino]pent-4-enoyl]amino]-2-propan-2-ylhexanamide. Grades: 98%. CAS No. 150351-30-7. Molecular formula: C37H61N5O7S. Mole weight: 719.98. | |
| PD 135158 | PD 135158. Group: Biochemicals. Grades: Purified. CAS No. 130285-87-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| PD 135158 | PD 135158 is a nonpeptide CCK2 receptor antagonist. It also exhibits agonist activity at the rat pancreatic CCKA receptor to stimulate pancreatic enzyme secretion. Uses: Anti-anxiety agents. Synonyms: 4-[[(1R)-2-[[(2R)-3-(1H-Indol-3-yl)-2-methyl-1-oxo-2-[[[[(1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]hept-2-yl]oxy]carbonyl]amino]propyl]amino]-1-phenylethyl]amino]-4-oxobutanoic acid. Grades: ≥98% by HPLC. CAS No. 130285-87-9. Molecular formula: C35H44N4O6. Mole weight: 616.76. | |
| PD 135390 | PD 135390 has been found to be a HIV-1 protease inhibitor that could probably be effective against HIV infections. Synonyms: PD-135390; PD135390; PD 135390; 5-((2S)-N-(1-(allylthio)-2-amino-2-oxoethyl)-2-(morpholine-4-sulfonamido)-3-phenylpropanamido)-N-butyl-6-cyclohexyl-4-hydroxy-2-isopropylhexanamide. Grades: 98%. CAS No. 150351-31-8. Molecular formula: C37H61N5O7S2. Mole weight: 752.04. | |
| PD 136450 | PD-136,450 is a Cholecystokinin type B receptor antagonist originated by Pfizer. It is a partial secretory agonist in the stomach and a full agonist in the pancreas of the rat. It has therapeutic potential as acid antisecretory drugs, and may be of use as adjuvant therapy for gastrin sensitive tumours. No development for the treatment of Peptic ulcer was reported. Uses: Peptic ulcer. Synonyms: Cam 1189; Cam-1189; Cam1189; PD-136450; PD136450; PD 136450;(E)-4-((2-(2-(((adamantan-2-yloxy)carbonyl)amino)-3-(1H-indol-3-yl)-2-methylpropanamido)-1-phenylethyl)amino)-4-oxobut-2-enoic acid. Grades: 98%. CAS No. 139067-52-0. Molecular formula: C35H40N4O6. Mole weight: 612.72. | |
| PD 138142 | PD 138142 is a water soluble Sterol O-acyltransferase inhibitor. Triacylglycerol secretion is decreased in the presence of PD-138142-15. Preclinical development for Hypercholesterolaemia in USA was discontinued. Uses: Hypercholesterolaemia. Synonyms: PD-138142; PD138142; PD 138142; 2,6-diisopropylphenyl (2,6-diisopropylphenoxy)carbonylsulfamate. Grades: 98%. CAS No. 142642-31-7. Molecular formula: C25H35NO5S. Mole weight: 461.62. | |
| PD-138312 | PD-138312 is a novel broad-spectrum 7-pyrrolidinyl fluoronaphthyridines with a difluorophenyl substitution or a cyclopropyl at the 1 positions, respectively. It has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens in vitro activity. It was evaluated for its in vivo potencies against acute systemic infections and pneumococcal in mice pneumonia model. Uses: Pd-138312 has been demonstrated to have excellent therapeutic potential against clinically important gram-positive pathogens. Synonyms: PD-138312; PD138312; PD 138312;7-(3-(2-Aminopropan-2-yl)pyrrolidin-1-yl)-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carboxylic acid;7-(3-(1-Amino-1-methylethyl)-1-pyrrolidinyl)-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid. Grades: >98%. CAS No. 107334-06-5. Molecular formula: C19H23FN4O3. Mole weight: 374.41. | |
| PD 140248 | PD 140248, a fluoronaphthyridine compound, has been found to have potential antibacterial effect especially against gram-positive pathogens. It has not been reported about its development status since 2000. Synonyms: PD-140248; PD140248; PD 140248; 7-(3-(1-Aminoethyl)-1-pyrrolidinyl)-1-(2,4-difluorophenyl)-6-fluoro-1,4-dihydro-4-oxo-1,8-naphthyridine-3-carboxylic acid; 1,8-Naphthyridine-3-carboxylic acid, 7-(3-(1-aminoethyl-1-pyrrolidinyl))-1-(2,4-difluorophenyl)-6-fluoro-1,4-d. Grades: 98%. CAS No. 147208-55-7. Molecular formula: C21H19F3N4O3. Mole weight: 432.39. | |
| PD-140376 | PD-140376 has been found to be a cholecystokininB/gastrin receptor antagonist that could probably be useful in the study of sorts of gastrointestinal disorders. Synonyms: PD-140376; PD 140376; AC1L52KZ; 3-((4-Aminophenyl)methyl)-N-(alpha-methyl-N-((tricyclo(3.3.1.1)dec-2-yloxy)carbonyl)-D-tryptophyl)-beta-alanine; OR223333. Grades: 98%. CAS No. 149027-97-4. Molecular formula: C33H40N4O5. Mole weight: 572.71. | |
| PD 142505-0028 | PD 142505-0028, also know as CI-1017, has been found to be a muscarinic agonist that could exhibit effect against cognition disorder so that was once studied in AD. Synonyms: CI-1017; CI1017; CI 1017; PD-142505-0028; PD42505-0028; PD 142505-0028; CTK4D0956; 1-Azabicyclo[2.2.1]heptan-3-one,O-[3-(3-methoxyphenyl)-2-propyn-1-yl]oxime. Grades: 98%. CAS No. 161774-09-0. Molecular formula: C18H20N2O6. Mole weight: 360.36. | |
| PD 144418-d7 Oxalate | PD 144418-d7 Oxalate. Group: Biochemicals. Alternative Names: 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine-d7 Oxalate. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: C20H17D7N2O5, Molecular Weight: 379.46. US Biological Life Sciences. | Worldwide |
| PD 144418 oxalate | PD 144418 oxalate is a very selective sigma 1 agent (Ki values are 0.08 and 1377 nM for σ1 and σ2 respectively), devoid of any significant affinity for other receptors and that sigma 1 site may modulate actions in the CNS. PD 144418 antagonizes mescaline-induced scratching in mice following i.p. administration, and also attenuates cocaine-induced hyperactivity in mice. Synonyms: PD 144418 oxalate; PD144418 oxalate; PD-144418 oxalate; 1,2,3,6-Tetrahydro-5-[3-(4-methylphenyl)-5-isoxazolyl]-1-propylpyridine oxalate. Grades: ≥98% by HPLC. CAS No. 154130-99-1. Molecular formula: C18H22N2O.C2H2O4. Mole weight: 372.42. | |
| PD 145065 - CAS 153049-49-1 | A highly potent but non-selective endothelin receptor antagonist [IC??= 4 nM for the ETA receptor (rabbit renal artery vascular smooth muscle cells); IC?? = 15 nM for the ETB receptor (rat cerebellum)]. Group: Fluorescence/luminescence spectroscopy. |  |
| PD 145305 | PD 145305 is an inactive analog of PD 150606, a selective calpain inhibitor. Synonyms: 3-phenyl-2-sulfanylpropanoic acid; Benzylthioglykolsaure. Grades: ≥95%. CAS No. 90536-15-5. Molecular formula: C9H10O2S. Mole weight: 182.2. | |
| PD 146176 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| PD 146176 | PD 146176 is a specific, non-competitve 15-lipoxygenase (15-LOX) inhibitor (Ki = 197nM), without effect on 5-LOX, 12-LOX, COX-1 or COX-2 (IC50 = 0.54 μM for 15-LOX in rabbit reticulocytes). It is known that PD-146176 acts as a noncompetitive inhibitor towards 15-LO, displaying a Ki=197 nM. Furthermore, PD-146176 reduces monocyte macrophage enrichment of atherosclerotic lesions and development of fibrofoamy and fibrous plaque. Synonyms: 6,11-Dihydro[1]benzothiopyrano[4,3-b]indole; PD 146176; PD-146176; PD146176; NSC 168807; NSC-168807; NSC168807. Grades: ≥98% by HPLC. CAS No. 4079-26-9. Molecular formula: C15H11NS. Mole weight: 237.32. | |
| PD 146176 | PD 146176. Group: Biochemicals. Grades: Purified. CAS No. 4079-26-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD 149163 | PD 149163. Group: Biochemicals. Alternative Names: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine ethyl ester; PF-01472472; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine ethyl ester. Grades: Highly Purified. CAS No. 169528-11-4. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C42H71N9O6. US Biological Life Sciences. | Worldwide |
| PD-149163 | PD-149163. Group: Biochemicals. Alternative Names: N2-[(2S)-2,6-Diaminohexyl]-L-lysyl-L-prolyl-L-tryptophyl-3-methyl-L-valyl-L-leucine Ethyl Ester; PF-01472472; (S)-N-[N-[N-[1-[N2-(2,6-Diaminohexyl)-L-lysyl]-L-prolyl]-L-tryptophyl]-3-methyl-L-valyl]-L-leucine Ethyl Ester. Grades: Highly Purified. CAS No. 169528-11-4. Pack Sizes: 10mg. Molecular Formula: C42H71N9O6, Molecular Weight: 798.07. US Biological Life Sciences. | Worldwide |
| PD 149163 tetrahydrochloride hydrate | ?90% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD150606 | PD 150606 is a selective, cell-permeable non-peptide calpain inhibitor with K i values of 0.21 μM and 0.37 μM for μ- and m-calpains respectively, which is neuroprotective [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 179528-45-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100529. | |
| PD 150606 | PD 150606. Group: Biochemicals. Alternative Names: (2Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic Acid; (Z)-3-(4-Iodophenyl)-2-mercapto-2-propenoic Acid. Grades: Highly Purified. CAS No. 179528-45-1. Pack Sizes: 10mg. Molecular Formula: C9H7IO2S, Molecular Weight: 306.12. US Biological Life Sciences. | Worldwide |
| PD 150606 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD 150606 | PD 150606 is a selective, cell-permeable inhibitor of calpains (Ki = 0.21 μM for μ-calpain (calpain-1) and 0.37 μM for m-calpain (calpain-2)). It targets the calcium binding sites of calpain. PD 150606 demonstrates high specificity for calpains relative to other proteases, and is a non-competitive inhibitor with respect to the substrate. Synonyms: PD-150606; PD150606. Grades: ≥95% by HPLC. CAS No. 179528-45-1. Molecular formula: C9H7IO2S. Mole weight: 306.12. | |
| PD 150,606 (3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid) | Cell permeable and selective calpain inhibitor. Interacts with calcium-binding domain of calpain. Neuroprotective. Ca2+-permeable AMPA receptor inhibitor. Apoptosis inhibitor. Group: Biochemicals. Alternative Names: 3-(4-Iodophenyl)-2-mercapto-(Z)-2-propenoic acid. Grades: Highly Purified. CAS No. 426821-41-2. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD 150606 - CAS 426821-41-2 | A cell-permeable, non-competitive, selective non-peptide calpain inhibitor [Ki = 210 nM for calpain-1 and 370 nM for calpain-2. Group: Fluorescence/luminescence spectroscopy. | |
| PD 151,242 | ?97%, powder. Group: Fluorescence/luminescence spectroscopy. | |
| PD 151746 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD 151746 | PD 151746 is a selective, cell-permeable calpain inhibitor with Ki of 0.26 μM for μ-Calpain, about 20-fold selectivity over m-calpain. Synonyms: PD-151746; PD 151746; PD151746. Grades: >98%. CAS No. 179461-52-0. Molecular formula: C11H8FNO2S. Mole weight: 237.25. | |
| PD 151746 - CAS 179461-52-0 | A cell-permeable, non-peptidic, and highly selective calpain inhibitor directed towards the calcium binding sites of calpain. Group: Fluorescence/luminescence spectroscopy. | |
| PD153035 | PD153035 (SU-5271; AG1517; ZM 252868) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271; AG1517; ZM 252868. CAS No. 153436-54-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14346. | |
| PD-153035 | PD153035 is a ATP-competitive EGFR inhibitor with an IC50 and Ki of 25 and 6 pM. PD153035 effectively blocks the enhancement of mitogenesis, induction of early gene expression, and oncogenic transformation that occur in response to EGF receptor stimulation. With human fibroblasts and epidermoid carcinoma cells, PD153035 at nanomolar concentrations rapidly inhibits EGFR autophosphorylation. With breast and ovarian cancer cells, PD153035 not only blocks cell growth via inhibition of EGFR, but also upregulates the expression of the tumor suppressor retinoic acid receptor-beta 2 (RAR-beta2). Uses: Antineoplastic agents. Synonyms: AG 1517; AG1517; AG-1517; NSC 669364; NSC669364; NSC-669364; PD 153035; PD153035; SU 5271; SU5271; SU-5271; WHI-P 79. Grades: >98%. CAS No. 153436-54-5. Molecular formula: C16H14BrN3O2. Mole weight: 360.211. | |
| PD 153035 - CAS 153436-54-5 | An extremely potent, cell-permeamble, reversible, ATP-competitive and specific inhibitor of the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC?? = 25 pM; Ki = 6 pM). Group: Fluorescence/luminescence spectroscopy. | |
| PD153035 HCl | PD153035 is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. Synonyms: SU5271; SU 5271; AG 1517; AG-1517; SU-5271 (AG1517) HCl; ZM 252868 HCl; ZM-252868 HCl; ZM252868 HCl; PD153035 HCl; PD 153035 HCl; PD-153035 HCl; AG 1517 hydrochloride; AG1517 hydrochloride; AG-1517 hydrochloride. Grades: >98%. CAS No. 183322-45-4. Molecular formula: C16H14BrN3O2.HCl. Mole weight: 396.67. | |
| PD153035 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD153035 Hydrochloride | PD153035 Hydrochloride (SU-5271 Hydrochloride) is a potent EGFR inhibitor with K i and IC 50 of 6 and 25 pM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SU-5271 Hydrochloride; AG1517 Hydrochloride; ZM 252868 Hydrochloride. CAS No. 183322-45-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12013. | |
| PD-156707 | PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 162412-70-6. Pack Sizes: 5 mg. Product ID: HY-123744. | |
| PD-156707 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD158780 | PD158780 is a potent, cell-permeable, reversible ATP-competitive inhibitor of EGFR tyrosine kinase activity with IC50 values of 0.008, 49 and 52 nM for EGFR, ErbB2 (HER2) and Erb4 (HER4). Synonyms: PD-158780; PD 158780; PD158780. Grades: >98%. CAS No. 171179-06-9. Molecular formula: C14H12BrN5. Mole weight: 330.18. | |
| PD 158780 | PD 158780. Group: Biochemicals. Grades: Purified. CAS No. 171179-06-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD 158780 - CAS 171179-06-9 | A potent, cell-permeable, reversible, ATP-competitive inhibitor of the EGFR tyrosine kinase activity (IC?? = 8 pM). Group: Fluorescence/luminescence spectroscopy. | |
| PD159206 | PD-159206 is a nucleocapsid inhibitor. It exhibits good antiviral activity against HIV. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PD-159206; PD159206; PD 159206; CI 1013; CI-1013; CI1013; DIBA 4. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 171744-42-6. Molecular formula: C26H32N2O6S2. Mole weight: 532.67. Purity: >95%. IUPACName: N,N'-[Dithiobis(2,1-phenylenecarbonyl)]bis[isoleucine]. Canonical SMILES: O=C(N[C@@H]([C@@H](C)CC)C(O)=O)C1=CC=CC=C1SSC2=CC=CC=C2C(N[C@@H]([C@@H](C)CC)C(O)=O)=O. Product ID: ACM171744426. Alfa Chemistry ISO 9001:2015 Certified. Categories: DIBA-4 ENANTIOMER. |  |
| PD 160170 | PD 160170 is a potent, selective non-peptidic neuropeptide Y1 receptor antagonist (Ki = 48 nM), which is selective over Y2 and Y5 receptors (Ki > 10 μM). Synonyms: PD 160170; PD160170; PD-160170; 6-[[2-(1-Methylethyl)phenyl]]sulfonyl-5-nitro-8-quinolinamine. Grades: ≥98% by HPLC. CAS No. 181468-88-2. Molecular formula: C18H17N3O4S. Mole weight: 371.41. | |
| PD 160170 | PD 160170. Group: Biochemicals. Grades: Purified. CAS No. 181468-88-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PD-160725 2-Hydroxyethanesulfonate | PD-160725 2-Hydroxyethane sulfonate. Group: Biochemicals. Alternative Names: 2-Hydroxyethanesulfonic Acid 1,4-Dihydro-6-methyl-7-nitro-5-(1-piperidinylmethyl)-2,3-quinoxalinedione; PD-160725 Isethionate Salt. Grades: Highly Purified. CAS No. 1262769-92-5. Pack Sizes: 10mg. Molecular Formula: C17H24N4O8S, Molecular Weight: 444.46. US Biological Life Sciences. | Worldwide |
| PD 161570 | PD 161570. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H35Cl2N7O. US Biological Life Sciences. | Worldwide |
| PD-161570 | A novel FGF-1 receptor tyrosine kinase inhibitor which has been shown to effectively suppress constitutive phosphorylation of the FGF-1 receptor in human ovarian carcinoma cells. Group: Biochemicals. Alternative Names: N-[6- (2, 6-Dichlorophenyl) -2-[[4- (diethylamino) butyl]amino]pyrido[2, 3-d]pyrimidin-7-yl]-N'- (1, 1-dimethylethyl) urea; 1-Tert-butyl-3-[6-(2,6-dichloro-phenyl)-2-(4-diethylamino-butylamino)pyrido[2,3-d]pyrimidin-7-yl]urea. Grades: Highly Purified. CAS No. 192705-80-9. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD-161570 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD-161570 | PD-161570 is a selective inhibitor of human FGF-1 receptor tyrosine kinase, with IC50 values to be 40, 262 and 3700 nM for FGFR1, PDGFR and EGFR tyrosine kinases, respectively. In addintion, PD-161570 inhibits FGFR receptor phosphorylation (IC50 = 622 nM) and growth of A121 cells in vitro. Synonyms: N-[6-(2,6-Dichlorophenyl)-2-[[4-(diethylamino)butyl]amino]pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)urea; PD-161570; PD 161570; PD161570. CAS No. 192705-80-9. Molecular formula: C26H35Cl2N7O. Mole weight: 532.51. | |
| PD-161570 | PD-161570 is a potent and ATP-competitive human FGF-1 receptor inhibitor with an IC50 of 39.9 nM and a Ki of 42 nM. PD-161570 also inhibits the PDGFR, EGFR and c-Src tyrosine kinases with IC50 values of 310 nM, 240 nM, and 44 nM, respectively. PD-161570 inhibits PDGF-stimulated autophosphorylation and FGF-1 receptor phosphorylation with IC50s of 450 nM and 622 nM, respectively[1][2]. PD-161570 is also a bone morphogenetic proteins (BMPs) and TGF-? signaling inhibitor[3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 192705-80-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-100434. | |
| PD-161989 2-Hydroxyethanesulfonate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD-161989 2-Hydroxyethanesulfonate | PD-161989 2-Hydroxyethane sulfonate. Group: Biochemicals. Alternative Names: 2-Hydroxyethanesulfonic Acid 1,4-Dihydro-6-methyl-7-nitro-5-(1-pyrrolidinylmethyl)-2,3-quinoxalinedione. Grades: Highly Purified. CAS No. 1262770-05-7. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PD 166285 | PD 166285. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C26H29Cl4N5O2. US Biological Life Sciences. | Worldwide |
| PD-166285 | A broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6- (2, 6-Dichlorophenyl) -2-[[4-[2- (diethylamino) ethoxy]phenyl]amino]-8-methylpyrido[2, 3-d]pyrimidin-7 (8H) -one. Grades: Highly Purified. CAS No. 212391-63-4. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| PD 166285 - CAS 212391-63-4 | A cell-permeable, orally bioavailable, ATP-competitive, broad-spectrum tyrosine kinase inhibitor that suppresses angiogenesis both in vitro and in vivo. Group: Fluorescence/luminescence spectroscopy. | |
| PD-166285-d4 | A labeled broad-spectrum receptor tyrosine kinase (RTK) inhibitor. Group: Biochemicals. Alternative Names: 6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy-d4]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PD 166285 dihydrochloride | PD 166285, a novel protein tyrosine kinase inhibitor of a new structural class, is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1), and PDGFRβ (platelet-derived growth factor receptor β) (IC50 values are 8.4, 39.3 and 98.3 nM respectively). PD 166285 also inhibits the checkpoint kinases Wee1 and MYT1 (Myt1), abolishes Cdc2 phosphorylation in numerous tumor cell lines, and abrogates the G2 checkpoint. Synonyms: PD 166285 dihydrochloride; PD166285 dihydrochloride; PD-166285 dihydrochloride6-(2,6-Dichlorophenyl)-2-[[4-[2-(diethylamino)ethoxy]phenyl]amino]-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one dihydrochloride. Grades: ≥99% by HPLC. CAS No. 212391-63-4. Molecular formula: C26H27Cl2N5O2.2HCl. Mole weight: 585.35. | |
| PD-166285 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD166326 | PD166326 is one of the most potent members of the pyridopyrimidine class of protein tyrosine kinase inhibitors. In mice with the CML-like disease, PD166326 rapidly inhibited Bcr/Abl kinase activity after a single oral dose and demonstrated marked antileukemic activity in vivo. In vivo, PD166326 was also superior to imatinib mesylate in inhibiting the constitutive tyrosine phosphorylation of numerous leukemia-cell proteins, including the src family member Lyn. PD166326 also prolonged the survival of mice with imatinib mesylate-resistant CML induced by the Bcr/Abl mutants P210/H396P and P210/M351T. Synonyms: PD-166326; PD 166326; 6-(2,6-Dichlorophenyl)-2-[[3-(hydroxymethyl)phenyl]amino]-8-methyl-pyrido[2,3-d]pyrimidin-7(8H)-one. CAS No. 185039-91-2. Molecular formula: C21H16Cl2N4O2. Mole weight: 427.28. | |
| PD166326 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PD166326 | PD166326 is a pyridopyrimidine-type inhibitor of receptor tyrosine kinases , with IC 50 s of 6 nM and 8 nM for Src and Abl , respectively. PD166326 exhibits antileukemic activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 185039-91-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118144. | |
| PD 166793 | PD 166793 is a broad-spectrum matrix metalloproteinase (MMP) inhibitor (IC50s = 6.1, 0.047, 0.012, 7.2, 7.9, 0.008, and 0.24 μM for MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, MMP-13CD, and MMP-14CD, respectively). It displays high affinity for MMP-2, -3 and -13 (IC50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. In vivo, PD 166793 (2 mg/kg per day, p.o.) reduces left ventricular (LV) peak wall stress in a porcine model of congestive heart failure. Synonyms: N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine; PD-166793; PD 166793; PD166793; PD-166793-0000. Grades: ≥99% by HPLC. CAS No. 199850-67-4. Molecular formula: C17H18BrNO4S. Mole weight: 412.3. | |
| PD 166793 | PD 166793. Group: Biochemicals. Alternative Names: PD 166793-0000; N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-Valine. Grades: Highly Purified. CAS No. 199850-67-4. Pack Sizes: 10mg. Molecular Formula: C17H18BrNO4S, Molecular Weight: 412.3. US Biological Life Sciences. | Worldwide |
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