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| Product | Description | |
|---|---|---|
| PF-06747711 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF-06747775 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06748962 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06758955 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06761281 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06764427 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06767832 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06821497 | PF-06821497. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one. CAS No. 1844849-10-0. Molecular formula: C22H24Cl2N2O5. Mole weight: 467.34. Purity: 0.98. Product ID: ACM1844849100. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PF-06827443 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06835919 | PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF-06835919; PF 06835919; PF06835919; MDK1846; MDK-1846; MDK 1846; ketohexokinase inhibitor; ketohexokinase-In-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2102501-84-6. Molecular formula: C16H19F3N4O2. Mole weight: 356.35. Purity: >98%. IUPACName: 2-((1R,5S,6R)-3-(2-((S)-2-methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)acetic acid. Canonical SMILES: O=C(C[C@@H]1[C@]2(CN(C[C@@]12[H])C3=NC(N4[C@H](CC4)C)=NC(C(F)(F)F)=C3)[H])O. Product ID: ACM2102501846. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ketohexokinase inhibitor 1. | |
| PF-06835919 | PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK) , with IC 50 s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketohexokinase inhibitor 1. CAS No. 2102501-84-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00461. |  |
| PF-06840003 | PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 ?M, 0.59 ?M, and 1.5 ?M for hIDO-1, dIDO-1, and mIDO-1, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EOS200271. CAS No. 198474-05-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101111. | |
| PF-06869206 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06873600 | Ebvaciclib, also known as PF-06873600, is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon administration, PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ebvaciclib; PF-06873600; PF 06873600; PF06873600. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2185857-97-8. Molecular formula: C20H27F2N5O4S. Mole weight: 471.52. Purity: >98%. IUPACName: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-. Canonical SMILES: O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@H]4[C@](C)(O)CCC4. Product ID: ACM2185857978. Alfa Chemistry ISO 9001:2015 Certified. | |
| PF-06873600 | PF-06873600 Inhibitor. Uses: Scientific use. Product Category: T8463. CAS No. 2185857-97-8. |  |
| PF-06928215 | PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 ??. PF-06928215 has a high binding affinity of 0.2 ?M (Kd)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2378173-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114182. | |
| PF-06928215 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06939999 | PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRMT5-IN-3. CAS No. 2159123-14-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131493. | |
| PF-06952229 | PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1801333-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136244. | |
| PF-07258669 | PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2755890-53-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148349. | |
| PF-07265807 | PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC 50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2412356-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147218. | |
| PF-07284892 | PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC 50 value of 21 nM. PF-07284892 decreases the expression of pERK [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-558. CAS No. 2498597-94-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-153740. | |
| PF-07321332 | Nirmatrelvir, also known as PF-07321332 (brand name: Paxlovid), is an orally bioavailable 3C-like protease (3CLPRO) inhibitor and SARS-CoV-2 Mpro inhibitor. This drug is being investigated for safety, tolerability, and pharmacokinetics before moving on to studies of efficacy in the treatment or prophylaxis of COVID-19. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. PF-07321332 is an oral COVID-19 antiviral clinical candidate. By inhibiting the main protease, PF-07321332 prevents the virus from cleaving long protein chains into the parts it needs to reproduce itself. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nirmatrelvir; PF-07321332; PF 07321332; PF07321332; brand name Paxlovid. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.54. Purity: >98%. IUPACName: (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide. Canonical SMILES: [H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C#N)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C. Product ID: ACM2628280408. Alfa Chemistry ISO 9001:2015 Certified. | |
| PF-07328948 | PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2936625-34-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-159648. | |
| PF 1018 | PF1018 is an insecticidal agent isolated from the culture broth of Humicola sp. PF1018. Synonyms: Antibiotic PF 1018; PF1018. CAS No. 131256-42-3. Molecular formula: C28H35NO3. Mole weight: 433.6. |  |
| PF 1022A | PF1022A, an anthelmintic cyclodepsipeptide isolated from cultured mycelia of Mycelia Sterilia, has very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. It has potent repellant activity against Ascaridiagalli in chicken. In vitro, it has activity against Trichinella spiralis and Nippostrongylus brasiliensis. Synonyms: PF1022A; PF-1022A; cyclo[N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe-N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe]; cyclo[N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl-N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl]; Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]. Grade: 98%. CAS No. 133413-70-4. Molecular formula: C52H76N4O12. Mole weight: 949.18. | |
| PF-1057A | PF-1057A is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057A; PF1057A. CAS No. 89162-70-9. Molecular formula: C31H56O10S2. Mole weight: 652.9. | |
| PF-1057B | PF-1057B is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057B; PF1057B. CAS No. 89020-47-3. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
| PF-1057C | PF-1057C is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057C; PF1057C. CAS No. 89020-48-4. Molecular formula: C35H60O12S2. Mole weight: 737. | |
| PF-1057D | PF-1057D is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057D; PF1057D. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
| PF-1092A | PF-1092A is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 3.0 x 10 nM. Synonyms: PF 1092A; PF1092A. Molecular formula: C17H20O5. Mole weight: 304.34. | |
| PF-1092B | PF-1092B is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(2) nM. Synonyms: PF 1092B; PF1092B. Molecular formula: C17H20O5. Mole weight: 304.34. | |
| PF-1092C | PF-1092C is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(3) nM. Synonyms: PF 1092C; PF1092C. Molecular formula: C15H18O4. Mole weight: 262.3. | |
| PF-1163A | PF-1163A is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: (3S,10R,13S)-3-[[4-(2-Hydroxyethoxy)phenyl]methyl]-13-[(2S)-2-hydroxypentyl]-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione. Grade: ≥95%. CAS No. 258871-59-9. Molecular formula: C27H43NO6. Mole weight: 477.6. | |
| PF-1163B | PF-1163B is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: Antibiotic PF-1163B; (-)-PF 1163B; 3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione. Grade: ≥95%. CAS No. 258871-60-2. Molecular formula: C27H43NO5. Mole weight: 461.63. | |
| PF-1355 | PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06281355. CAS No. 1435467-38-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100873. | |
| Pf 184 | Pf 184. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF 184, NCGC00263213-01, FT-0673646, 1187460-81-6, 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide. Product Category: Heterocyclic Organic Compound. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: C32H32ClFN6O4. Purity: >98 %. IUPACName: 8-[[2-[(3S,4R)-3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-5-chloropyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide. Canonical SMILES: CC1(CN(CC1(C)CO)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl)CO. Product ID: ACM1187460816. Alfa Chemistry ISO 9001:2015 Certified. Categories: PF-184563. | |
| PF184 | PF184. CAS No: 1187460-81-6 |  Sarchem Laboratories New Jersey NJ |
| PF 184 | PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. Group: Biochemicals. Alternative Names: 8- [ [ [5-Chloro-2- [3, 4-dimethyl-3, 4-bis (hydroxymethyl) -1-pyrrolidinyl] -4-pyridinyl] carbonyl] amino] -1- (4-fluorophenyl) -4, 5-dihydro-1H-benz [g] indazole-3-carboxamide. Grades: Highly Purified. CAS No. 1187460-81-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PF-2545920 hydrochloride | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF2EH | PF2EH. Group: Organic light-emitting diode (oled) materials. Alternative Names: POLY(9 9-BIS-(2-ETHYLHEXYL)-9H-FLUORENE&; POLY(9,9-DI-(2-ETHYLHEXYL)FLUORENYL-2,&; Poly[9,9-di-(2-ethylhexyl)fluorenyl-2,7-diyl]; Poly[9,9-bis-(2-ethylhexyl)-9H-fluorene-2,7-diyl]; Poly[9,9-bis(2-ehtylhexyl)fluorenyl-2,7-diyl]; Poly[9,9-bis-(2-ethylhexyl)-9H-f. CAS No. 188201-16-3. Product ID: (2-amino-2-oxoethyl) 3-[benzyl-(4-chlorophenyl)sulfamoyl]-4-chlorobenzoate. Molecular formula: 493.4g/mol. Mole weight: C22H18Cl2N2O5S. C1=CC=C (C=C1)CN (C2=CC=C (C=C2)Cl)S (=O) (=O)C3=C (C=CC (=C3)C (=O)OCC (=O)N)Cl. InChI=1S / C22H18Cl2N2O5S / c23-17-7-9-18 (10-8-17) 26 (13-15-4-2-1-3-5-15) 32 (29, 30) 20-12-16 (6-11-19 (20) 24) 22 (28) 31-14-21 (25) 27 / h1-12H, 13-14H2, (H2, 25, 27). UZIUTJBYUHKEGE-UHFFFAOYSA-N. |  |
| PF-3644022 | PF-3644022 is a potent freely reversible ATP-competitive compound that inhibits MK2 activity (Ki = 3 nM) with good selectivity when profiled against 200 human kinases. PF-3644022 is a benzothiophene inhibitor of mitogen-activated protein kinase-activated protein kinase 2 inhibits tumor necrosis factor α production and has oral anti-inflammatory efficacy in acute and chronic models of inflammation. Group: Biochemicals. Alternative Names: (10R)-9, 10, 11, 12-Tetrahydro-10-methyl-3-(6-methyl-3-pyridinyl)-8H-[1, 4]diazepino[5', 6':4, 5]thieno[3, 2-f]quinolin-8-one. Grades: Highly Purified. CAS No. 1276121-88-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3644022 | PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNF? production and has anti-inflammatory effect[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1276121-88-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107427. | |
| PF-3644022 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-3758309 | PF-3758309 (PF-03758309) is a potent, orally available, and reversible ATP-competitive inhibitor of PAK4 ( K d = 2.7 nM; K i =18.7 nM). PF-3758309 has the expected cellular functions of a PAK4 inhibitor: inhibition of anchorage-independent growth, induction of apoptosis, cytoskeletal remodeling, and inhibition of proliferation [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-03758309. CAS No. 898044-15-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13007. | |
| PF-3774076 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 3845 | PF 3845 is a selective fatty acid amide hydrolase (FAAH) inhibitor (Ki = 0.23uM). Reduces inflammatory pain via a cannabinoid receptor-dependent mechanism. Highly efficacious and selective in vivo. Displays no activity at FAAH-2 (IC50 >10uM). Group: Biochemicals. Alternative Names: N-3-Pyridinyl-4- [ [3- [ [5- (trifluoromethyl) -2-pyridinyl] oxy] phenyl] methyl] -1-piperidinecarboxamide. Grades: Highly Purified. CAS No. 1196109-52-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-3845 | PF-3845 is a potent, selective, irreversible and orally active inhibitor of fatty acid amide hydrolase (FAAH) , with a K i of 0.23 μM. PF-3845 is a covalent inhibitor that carbamylates FAAH's serine nucleophile. PF-3845 can reduce pain sensation, inflammation, and anxiety/depression without substantial effects on motility or cognition [1] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1196109-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14380. | |
| PF 3845 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4136309 | PF-4136309 is a potent, selective, and orally bioavailable CCR2 antagonist, with IC50s of 5.2 nM, 17 nM and 13 nM for human, mouse and rat CCR2. Uses: Scientific research. Group: Signaling pathways. Alternative Names: INCB8761. CAS No. 1341224-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13245. | |
| PF-4191834 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-429242 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF429242 dihydrochloride | PF429242 dihydrochloride is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2248666-66-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13447A. | |
| PF 431396 | PF 431396 is a dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor (IC50 values are 2 and 11 nM respectively). Promotes osteoblast recruitment and activity, and stimulates bone formation in ovariectomized rats. Group: Biochemicals. Grades: Highly Purified. CAS No. 717906-29-1. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O?S. US Biological Life Sciences. | Worldwide |
| PF-431396 | PF-431396 is an orally active dual focal adhesion kinase (FAK) and proline-rich tyrosine kinase 2 (PYK2) inhibitor, with IC50 values of 2 nM and 11 nM, respectively[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 717906-29-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-10460. | |
| PF-431396 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4618433 | PF-4618433 is a potent and selective PYK2 inhibitor, with an IC50 of 637 nM. PF-4618433 may be suitable for the research of osteoporosis, craniofacial and appendicular skeletal defects and for targeted bone regeneration[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1166393-85-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18312. | |
| PF-4708671 | PF-4708671 is a highly specific inhibitor of p70 ribosomal S6 kinase (S6K1). PF-4708671 inhibits S6K1-mediated phosphorylation of S6 protein in response to IGF-1 (insulin-like growth factor 1), while having no effect on highly related RSK (p90 ribosomal S6 kinase) and MSK (mitogen- and stress-activated kinase) kinases. Group: Biochemicals. Alternative Names: 2-[[4-(5-ethyl-4-pyrimidinyl)-1-piperazinyl]methyl]-6-(trifluoromethyl)-1H-benzimidazole; PF 4708671. Grades: Highly Purified. CAS No. 1255517-76-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-4708671 | PF-4708671 is a potent cell-permeable S6K1 inhibitor with a K i of 20 nM and IC 50 of 160 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255517-76-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15773. | |
| PF-4708671 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 477736 | PF 477736 (PF 00477736) is a potent, selective and ATP-competitive inhibitor of Chk1, with a Ki of 0.49 nM, it is also a Chk2 inhibitor, with a Ki of 47 nM. PF 477736 shows <100-fold selectivity for Chk1 over VEGFR2, Fms, Yes, Aurora-A, FGFR3, Flt3, and Ret (IC50=8 (Ki), 10, 14, 23, 23, 25, and 39 nM, respectively). PF 477736 can enhance Gemcitabine antitumor activity in vitro and in vivo[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF 00477736. CAS No. 952021-60-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10032. | |
| PF 477736 | Selective checkpoint kinase 1 (Chk1) inhibitor (Ki values are 0.49 and 47 nM for Chk1 and Chk2 respectively). Abrogates cell cycle arrest at S and G2-M checkpoints; sensitizes cells to DNA damage. Group: Biochemicals. Grades: Highly Purified. CAS No. 952021-60-2. Pack Sizes: 10mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| PF-477736 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4778574 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4800567 | PF-4800567 is a potent and selective inhibitor of casein kinase 1? (CK1?), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1? (IC50, 711 nM). Uses: Scientific research. Group: Signaling pathways. CAS No. 1188296-52-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12470. | |
| PF-4800567 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-4800567 Hydrochloride | PF 4800567 is a selective casein kinase 1ε inhibitor; displays 22-fold greater potency towards CK1ε than CK1δ (IC50 values are 32 and 711 nM for CK1ε and CK1δ respectively). ATP competitive. Displays minimal effect on the circadian clock. Group: Biochemicals. Alternative Names: 3-[(3-Chlorophenoxy)methyl]-1-(tetrahydro-2H-pyran-4-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Hydrochloride; PF 4800567 Hydrochloride. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-4942847 | PF-4942847. Group: Biochemicals. Alternative Names: 2-Amino-4-[4-chloro-2-[2-(4-fluoro-1H-pyrazol-1-yl)ethoxy]-6-methylphenyl]-N-(2,2-difluoropropyl)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidine-6-carboxamide; PF04942847. Grades: Highly Purified. CAS No. 1207961-33-8. Pack Sizes: 5mg. Molecular Formula: C22H23ClF3N7O2, Molecular Weight: 509.91. US Biological Life Sciences. | Worldwide |
| PF-4 (CXCL4) human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| PF-4 from mouse | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
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