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| Product | Description | |
|---|---|---|
| PF-5006739 | PF-5006739 is a potent and selective inhibitor of CK1?/? with IC50s of 3.9 nM and 17.0 nM, respectively. PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 attenuats opioid agent-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner[1]. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity[2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1293395-67-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12443. |  |
| PF-5006739 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF-5081090 | PF-5081090 (LpxC-4) is a potent LpxC inhibitor, is a rapidly bactericidal with broad-spectrum activity. PF-5081090 serves as a regulator of lipid A biosynthesis in Gram-negative pathogens[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LpxC-4. CAS No. 1312473-63-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103251. | |
| PF-5081090 | PF-5081090 is a pyridone methylsulfone hydroxamate LpxC inhibitor. PF-5081090 is used as an antibiotic in the treatment of serious gram-negative infections. Group: Biochemicals. Alternative Names: (αR)-4-(2-Fluoro-4-methoxyphenyl)-N-hydroxy-α-methyl-α-(methylsulfonyl)-2-oxo-1(2H)-pyridinebutanamide. Grades: Highly Purified. CAS No. 1312473-63-4. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| PF 514273 | PF 514273. Group: Biochemicals. Grades: Purified. CAS No. 851728-60-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-514273 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-514273 | A novel, bicyclic lactam-based cannabinoid-1 receptor antagonist for the treatment of obesity. Group: Biochemicals. Alternative Names: 2-(2-Chlorophenyl)-3-(4-chlorophenyl)-7-(2,2-difluoropropyl)-6,7-dihydro-2H-pyrazolo[3,4-f][1,4]oxazepin-8(5H)-one. Grades: Highly Purified. CAS No. 851728-60-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-5190457 | PF-5190457 (PF-05190457) is a potent and selective ghrelin receptor inverse agonist with a pKi of 8.36[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-05190457. CAS No. 1334782-79-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12584. | |
| PF-5274857 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-543 | PF-543 (Sphingosine Kinase 1 Inhibitor II) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 is >100-fold selectivity for SPHK1 over SPHK2. PF-543 is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II. CAS No. 1415562-82-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15425. | |
| PF-543 Citrate | PF-543 Citrate (Sphingosine Kinase 1 Inhibitor II Citrate) is a potent, selective, reversible and sphingosine-competitive SPHK1 inhibitor with an IC 50 of 2 nM and a K i of 3.6 nM. PF-543 Citrate is >100-fold selectivity for SPHK1 over SPHK2. PF-543 Citrate is an effective potent inhibitor of sphingosine 1-phosphate (S1P) formation in whole blood with an IC 50 of 26.7 nM. PF-543 Citrate induces apoptosis , necrosis, and autophagy [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Sphingosine Kinase 1 Inhibitor II Citrate. CAS No. 1415562-83-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15425A. | |
| PF-543 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-562271 | PF-562271 (VS-6062) is a potent, ATP-competitive and reversible FAK and Pyk2 kinase inhibitor with IC50s of 1.5 nM and 13 nM, respectively[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VS-6062. CAS No. 717907-75-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10459. | |
| PF-562271 | Potent ATP-competitive reversible inhibitor of FAK and Pyk2. PF-562,271 is a potent, ATP-competitive, reversible inhibitor of FAK and Pyk2 catalytic activity with a IC(50) of 1.5 and 14nm, respectively. In addition, PF-562,271 displayed robust inhibition in an inducible cell-based assay measuring phospho-FAK with an IC(50) of 5nm. PF-562,271 was evaluated against multiple kinases and displays >100X selectivity against a long list of non target kinases. In tests, PF-562,271 inhibits FAK phosphorylation in vivo in a dose-dependent fashion with a calculated EC50 of 93ng/ml using injections. Group: Biochemicals. Grades: Highly Purified. CAS No. 717907-75-0. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C21H20F3N7O3S, Target: FGFR. US Biological Life Sciences. | Worldwide |
| PF-562,271 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-573228 | PF-573228 is a potent and selective FAK inhibitor with IC 50 of 4 nM for purified recombinant catalytic fragment of FAK. Uses: Scientific research. Group: Signaling pathways. CAS No. 869288-64-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10461. | |
| PF-573228 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-573228 | A novel focal adhesion kinase inhibitor that has been shown to suppress the adverse phenotype of endocrine-resistant breast cancer cells and improve endocrine response in endocrine-sensitive cells. Group: Biochemicals. Alternative Names: 3, 4-Dihydro-6-[[4-[[[3- (methylsulfonyl) phenyl]methyl]amino]-5- (trifluoromethyl) -2-pyrimidinyl]amino]-2 (1H) -quinolinone; 6- [ (4- ( (3- (Methanesulfonyl) benzyl) amino) -5-trifluoro methyl pyrimidin-2-yl) amino] -3, 4-dihydro-1H-quinolin-2-one; PF 573228. Grades: Highly Purified. CAS No. 869288-64-2. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF-573228 | PF-573228 Inhibitor. Uses: Scientific use. Product Category: T2001. CAS No. 869288-64-2. |  |
| PF-6274484 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-6422899 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 670462 | PF 670462. Group: Biochemicals. Grades: Purified. CAS No. 950912-80-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-670462 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-670462 dihydrochloride | PF-670462 dihydrochloride is a potent and selective inhibitor of casein kinase ( CK1ε and CK1δ ) , with IC 50 s of 7.7 nM and 14 nM, respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 950912-80-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15490. | |
| PF-6808472 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-739 | PF-739 is an orally active and non-selective activator of AMPK. PF-739 activates 12 heterotrimeric AMPK complexes and significantly reduces the level of glucose in plasma complexes[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1852452-14-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117755. | |
| PF74 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF 750 | Fatty acid amide hydrolase (FAAH) inhibitor, selectively inhibiting FAAH within the central nervous system. Group: Biochemicals. Alternative Names: N-Phenyl-4-(3-quinolinylmethyl)-1-piperidinecarboxamide; N-Phenyl-4-(quinolin-3-ylmethyl)piperidine-1-carboxamide. Grades: Highly Purified. CAS No. 959151-50-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF8380 | PF8380. Group: Biochemicals. Alternative Names: 4-[3-Oxo-3-(2-oxo-2,3-dihydrobenzoxazol-6-yl)propyl]piperazine-1-carboxylic Acid 3,5-Dichlorobenzyl Ester; 4-[3-(2,3-Dihydro-2-oxo-6-benzoxazolyl)-3-oxopropyl]-1-piperazinecarboxylic Acid (3,5-Dichlorophenyl)methyl Ester. Grades: Highly Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg. Molecular Formula: C22H21Cl2N3O5, Molecular Weight: 478.33. US Biological Life Sciences. | Worldwide |
| PF 8380 | PF 8380. Group: Biochemicals. Grades: Purified. CAS No. 1144035-53-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-8380 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-8380 | PF-8380 is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 1144035-53-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344. | |
| PF-8380 hydrochloride | PF-8380 hydrochloride is a potent autotaxin inhibitor with an IC 50 of 2.8 nM in isolated enzyme assay and 101 nM in human whole blood. Uses: Scientific research. Group: Signaling pathways. CAS No. 2070015-01-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13344A. | |
| PF 915275 | PF 915275. Group: Biochemicals. Grades: Purified. CAS No. 857290-04-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| PF-9363 | PF-9363 (CTx-648) is a first-in-class potent and high selective KAT6A/KAT6B inhibitor. PF-9363 can be used for the research of cancer[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CTx-648. CAS No. 2569009-58-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-132283. | |
| PF-9366 | PF-9366 is a human methionine adenosyltransferase 2A (Mat2A) inhibitor, with an IC50 of 420 nM and a Kd of 170 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 72882-78-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107778. | |
| PF-956980 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-956980 Hydrate | PF-956980 is a FGF1 receptor antagonist; PDGF receptor modulator; Flt3 tyrosine kinase modulator; and VEGF antagonist. PF-956980 is used as immunosuppressive agent. Group: Biochemicals. Alternative Names: [(3R,4R)-4-Methyl-3-(methyl-7H-pyrrolo[2,3-d]pyrimidin-4-ylamino)-1-piperidinyl]-1-pyrrolidinylmethanone Hydrate. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF9601N | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-998425 | PF-998425 is a novel, nonsteroidal androgen receptor antagonist for sebum control and treatment of androgenetic alopecia. Group: Biochemicals. Alternative Names: rel- (-) -4-[ (1R, 2R) -2-Hydroxycyclohexyl]-2- (trifluoromethyl) benzonitrile. Grades: Highly Purified. CAS No. 1076225-27-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| PF9 tetrasodium salt | PF9 tetrasodium salt. Group: Biochemicals. Grades: Purified. CAS No. 851265-78-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| PFB-FDGlu | PFB-FDGlu is a selective lysosomal Glucocerebrosidase (GCase) substrate, which is metabolised by GCase to yield fluorescein. PFB-FDGlu is cell permeable and can be used with a flow cytometer to measure GCase activity in living cells on a single-cell basis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 209540-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139452. | |
| PFB-mercaptopropionyl-TOTA-Biotinyl | PFB-mercaptopropionyl-TOTA-Biotinyl. |  |
| PF-CBP1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFD | PFD. Group: Organic light-emitting diode (oled) materials. Alternative Names: Poly(9,9-di-n-dodecylfluorene). CAS No. 248256-53-3. |  |
| PfDHODH-IN-1 | PfDHODH-IN-1 is an analogue of the active metabolite of Leflunomide. PfDHODH-IN-1 is a Plasmodium falciparum dihydroorotate dehydrogenase (PfDHODH) inhibitor. PfDHODH-IN-1 has antimalarial activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 183945-55-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-135648. | |
| PF-DMB | PF-DMB. Group: Organic light-emitting diode (oled) materials. Alternative Names: PF-DMB; Poly[(9,9-dihexylfluoren-2,7-diyl)-alt-(2,5-dimethyl-1,4-phenylene)]. CAS No. 579505-48-9. 96%. | |
| PFE-360 | PFE-360 Inhibitor. Uses: Scientific use. Product Category: T16512. CAS No. 1527475-61-1. | |
| PffBT4T-2OD | Band gap: 1.65 eV. Uses: Requires hot ink processing (i.e. coating with ink at temperature 100-110 °c to ensure good coatability). Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials synthetic tools and reagents. Alternative Names: PCE-11, Poly[(5, 6-difluoro-2, 1, 3-benzothiadiazol-4, 7-diyl)-alt-(3, 3'''-di(2-octyldodecyl)-2, 2', 5', 2'', 5'', 2'''-quaterthiophen-5, 5'''-diyl)]. CAS No. 1644164-62-4. Pack Sizes: 100 mg in glass bottle. Mole weight: (C62H88F2N2S5)n. | |
| PffBT4T-C9C13 | PffBT4T-C9C13. Group: Organic field effect transistor (ofet) materials organic solar cell (opv) materials. | |
| PFH-A | PFH-A. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dihexylfluorenyl-2,7-diyl)-co-(9,10-anthracene)]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 474975-22-9. Molecular formula: (C39H40)n. Product ID: ACM474975229-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFC Akademik Sofia. |  |
| PFHB | PFHB. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Poly[(9,9-dihexylfluorenyl-2,7-diyl)-alt-(N,N'-bis-{p-butylphenyl}-1,4-diaminophenylene)]. Product Category: Organic Light Emitting Diode (OLED). CAS No. 870517-32-1. Molecular formula: (C51H62N2)n. Product ID: ACM870517321. Alfa Chemistry ISO 9001:2015 Certified. Categories: PHBV. | |
| PFI-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFI-1 | PFI-1. Group: Biochemicals. Alternative Names: 2-Methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide; 2-Methoxy-N- (1, 2, 3, 4-tetrahydro-3-methyl-2-oxo-6-quinazolinyl) benzenesulfonamide. Grades: Highly Purified. CAS No. 1403764-72-6. Pack Sizes: 5mg. Molecular Formula: C16H17N3O4S, Molecular Weight: 347.39. US Biological Life Sciences. | Worldwide |
| PFI-1 | PFI-1 is a potent and highly selective protein interaction Inhibitor, which targets BET bromodomain. PFI-1 that efficiently blocks the interaction of BET BRDs with acetylated histone tails. Co-crystal structures showed that PFI-1 acts as an acetyl-lysine (Kac) mimetic inhibitor efficiently occupying the Kac binding site in BRD4 and BRD2. PFI-1 has antiproliferative effects on leukaemic cell lines and efficiently abrogates their clonogenic growth. Exposure of sensitive cell lines with PFI-1 results in G1 cell cycle arrest, down-regulation of MYC expression as well as induction of apoptosis and induces differentiation of primary leukaemic blasts. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFI1; PFI 1; PFI-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1403764-72-6. Molecular formula: C16H17N3O4S. Mole weight: 347.39. Purity: >98%. IUPACName: 2-methoxy-N-(3-methyl-2-oxo-1,2,3,4-tetrahydroquinazolin-6-yl)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1OC)(NC2=CC3=C(NC(N(C)C3)=O)C=C2)=O. Product ID: ACM1403764726. Alfa Chemistry ISO 9001:2015 Certified. Categories: PFM-1 mine. | |
| PFI-2 hydrochloride | PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC 50 value of 2.0??nM and (S)-PFI-2 shows inhibiting activity with IC 50 ?value of?1.0??μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-PFI-2 hydrochloride. CAS No. 1627607-87-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-18627A. | |
| PFI-2 Hydrochloride | PFI-2 ((R)-PFI-2 hydrochloride) hydrochloride is a potent and selective SET domain containing lysine methyltransferase 7 (SETD7) inhibitor. (R)-PFI-2 shows high inhibiting activity with IC50 value of 2.0??nM and (S)-PFI-2 shows inhibiting activity with IC50 ?value of?1.0??μM. PFI-2 hydrochloride can be used for the research of chronic kidney disease and inflammation response in the development of renal fibrosis. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFI-2; PFI2; PFI 2; (R)-PFI-2; (R)-PFI-2 hydrochloride. PFI-2 hydrochloride. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1627607-87-7. Molecular formula: C23H26ClF4N3O3S. Mole weight: 535.9826 g/mol. Purity: ≥98%. IUPACName: (R)-8-fluoro-N-(1-oxo-1-(pyrrolidin-1-yl)-3-(3-(trifluoromethyl)phenyl)propan-2-yl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide hydrochloride. Canonical SMILES: O=S(C1=CC2=C(CNCC2)C(F)=C1)(N[C@H](CC3=CC=CC(C(F)(F)F)=C3)C(N4CCCC4)=O)=O.[H]Cl. Product ID: ACM1627607877. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFI-3 | PFI-3 is a selective, potent and cell-permeable SMARCA2/4 bromodomain inhibitor with a Kd of 89 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 1819363-80-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-12409. | |
| PFI-3 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFI-4 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFI-653 | PFI-653, also known as Vanin-1-IN-1, is an inhibitor of vanin-1 (VNN1) enzyme which is a cell surface associated, giycosyiphosphatidyS inositol (GPi) anchored protein and plays an important role in metabolism and inflammation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFI-653; PFI 653; PFI653; Vanin-1-IN-1; Vanin-1IN-1; Vanin-1 IN-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2173134-00-2. Molecular formula: C18H22N6O2. Mole weight: 354.41. Purity: >98%. IUPACName: (2-((pyrazin-2-ylmethyl)amino)pyrimidin-5-yl)(8-oxa-2-azaspiro[4.5]decan-2-yl)methanone. Canonical SMILES: O=C(N1CC2(CCOCC2)CC1)C3=CN=C(NCC4=NC=CN=C4)N=C3. Product ID: ACM2173134002. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFI-90 | PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). Uses: Scientific research. Group: Signaling pathways. CAS No. 53995-62-3. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-139348. | |
| PFK-015 | PFK-015, a derivative of 3PO, is a specific PFKFB3 inhibitor. PFK-015 inhibits recombinant PFKFB3 with an IC50 value of 110 nM and inhibits PFKFB3 activity in cancer cells with an IC50 value of 20 nM. PFK-015 can be used for the research of multiple cancers such as lung cancer, stomach cancer, colon cancer and esophageal squamous cell carcinoma (ESCC)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4382-63-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12204. | |
| PFK15 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PFK-158 | PFK-158 is a potent and selective PFKFB3 inhibitor with an IC50 value 137 nM. PFK-158 reduces glucose uptake, ATP production, lactate release, and induces apoptosis and autophagy in cancer cells. PFK-158 has broad anti-tumor activity. PFK-158 can also enhance Colistin's resistance to bacteria[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1462249-75-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12203. | |
| PFK-158 | PFK-158, also known as ACT-PFK-158, is an inhibitor of 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatases (PFK-2/FBPase) isoform 3 (PFKFB3) with potential antineoplastic activity. Upon administration, PFKFB3 inhibitor PFK-158 binds to and inhibits the activity of PFKFB3, which leads to the inhibition of both the glycolytic pathway in and glucose uptake by cancer cells. This prevents the production of macromolecules and energy that causes the enhanced cellular proliferation in cancer cells as compared to that of normal, healthy cells. Depriving cancer cells of nutrients and energy leads to the inhibition of cancer cell growth. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PFK158; PFK 158; PFK158; ACTPFK158. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1462249-75-7. Molecular formula: C18H11F3N2O. Mole weight: 328.29. Purity: >98%. IUPACName: (E)-1-(pyridin-4-yl)-3-(7-(trifluoromethyl)quinolin-2-yl)prop-2-en-1-one. Canonical SMILES: O=C(C1=CC=NC=C1)/C=C/C2=NC3=CC(C(F)(F)F)=CC=C3C=C2. Product ID: ACM1462249757. Alfa Chemistry ISO 9001:2015 Certified. | |
| PFKFB3 Inhibitor, 3PO (6-Phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3 Inhibitor, 3PO, 3-(3-Pyridinyl)-1-(4-pyridinyl)-2-propen-1-one, (2E)-3-Pyridin-3-yl-1-pyridin-4-ylprop-2-en-1-one) | A cell-permeable dipyridinyl-propenone compound that selectively blocks PFK-2 (6-phosphofructo-2-kinase) activity of PFKFB3 isozyme over PFK-1 (6-phosphofructo-1-kinase) in a mixed-mode manner. Rapidly decreases fructose-2,6-bisphosphate (F-2,6-P2) and 2-deoxyglucose uptake, and lactate secretion; efficiently arrests proliferation of transformed cells (IC50 ~1.4uM in NHBE-ht/LT/ras) and suppresses tumor growth in several xenograft mouse models (70mg/kg, i.p.). The cytostatic and cytotoxic effects of 3PO is shown to be highly sensitive to the intracellular levels of F-6-P (fructose-6-phosphate) and F-2,6-P2. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| p-Fluoro-a-acetamidocinnamic Acid | p-Fluoro-a-acetamidocinnamic Acid. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| p-Fluorobenzyl Chloride | p-Fluorobenzyl Chloride. Group: Biochemicals. Alternative Names: α-Chloro-4-fluorotoluene; α-Chloro-p-fluorotoluene; 1-(Chloromethyl)-4-fluorobenzene; 4-Fluorobenzyl Chloride; 4-Fluorophenylmethyl Chloride; NSC 25084; 1-(Chloromethyl)-4-fluorobenzene. Grades: Highly Purified. CAS No. 352-11-4. Pack Sizes: 10g. Molecular Formula: C7H6ClF, Molecular Weight: 144.57. US Biological Life Sciences. | Worldwide |
| p-Fluoro-DL-phenylalanine | p-Fluoro-DL-phenylalanine. Uses: Peptide synthesis. Additional or Alternative Names: 4-fluoro-phenylalanine. Product Category: Amino Acids. CAS No. 51-65-0. Molecular formula: FC6H4CH2CH(NH2)COOH. Mole weight: 183.18. Canonical SMILES: NC(Cc1ccc(F)cc1)C(O)=O. ECNumber: 200-113-7. Product ID: ACM51650. Alfa Chemistry ISO 9001:2015 Certified. | |
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