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| Product | Description | |
|---|---|---|
| PF-06456384 trihydrochloride | PF-06456384 trihydrochloride is a highly potent and selective NaV1.7 inhibitor with an IC50 of 0.01 nM. PF-06456384 trihydrochloride has the potential for formalin pain model research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1834610-75-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118952A. |  |
| PF-06456384 trihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| PF-06459988 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06462894 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06463922 acetate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06465469 | PF-06465469 is a covalent inhibitor of ITK with an IC50 of 2?nM. PF-06465469 also inhibits BTK. PF-06465469 inhibits cell migration in response to CXCL12. PF-06465469 decreases PD-1 and LAG-3 expression. PF-06465469 can be used to study leukemia and T-cell lymphoma[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1407966-77-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108691. | |
| PF-06465469 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06648671 | PF-06648671 is a novel, brain-penetrable, and orally active γ-secretase modulator (GSM). PF-06648671 reduces Aβ42 and Aβ40, with concomitant increases in Aβ37 and Aβ38 in vitro. PF-06648671 is used for the study of Alzheimers disease [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1587727-31-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-120789. | |
| PF-06649283 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF06650833 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06651385 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06651481-00 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06651600 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06658607 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06658959-00 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06663181-00 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06663195 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06663827-00 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06663829-00 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06665105-00 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06672131 | ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06683324 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF06691283 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06700841 tosylate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06726304 | PF-06726304 is a potent and selective EZH2 inhibitor. PF-06726304 inhibits wild-type and Y641N mutant EZH2 with K i s of 0.7 and 3.0 nM, respectively. PF-06726304 displays robust antitumor growth activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1616287-82-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-103682. | |
| PF-06726304 acetate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06733804 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06737007 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06745013 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06745268 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06747711 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06747775 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06748962 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06758955 hydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06761281 | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06764427 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06767832 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06821497 | PF-06821497. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5,8-dichloro-2-[(4-methoxy-6-methyl-2-oxo-1H-pyridin-3-yl)methyl]-7-[(R)-methoxy(oxetan-3-yl)methyl]-3,4-dihydroisoquinolin-1-one. CAS No. 1844849-10-0. Molecular formula: C22H24Cl2N2O5. Mole weight: 467.34. Purity: 0.98. Product ID: ACM1844849100. Alfa Chemistry ISO 9001:2015 Certified. |  |
| PF-06827443 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06835919 | PF-06835919 (Ketohexokinase inhibitor 1) is an inhibitor of ketohexokinase (KHK) , with IC 50 s of 8.4 nM and 66 nM for KHK-C and KHK-A, respectively. PF-06835919 can be used for the study of metabolic disorders driven by the overconsumption of Fructose (HY-N0395) [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ketohexokinase inhibitor 1. CAS No. 2102501-84-6. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-U00461. | |
| PF-06835919 | PF-06835919, also known as MDK1846, is a potent ketohexokinase (KHK) inhibitor. PF-06835919 is reported in patent US 20170183328 A1, example 4. Increased fructose consumption and its subsequent metabolism have been implicated in hepatic steatosis, dyslipidemia, obesity, and insulin resistance in humans. Since ketohexokinase (KHK) is the principal enzyme responsible for fructose metabolism, identification of a selective KHK inhibitor may help to further elucidate the effect of KHK inhibition on these metabolic disorders. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF-06835919; PF 06835919; PF06835919; MDK1846; MDK-1846; MDK 1846; ketohexokinase inhibitor; ketohexokinase-In-1. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2102501-84-6. Molecular formula: C16H19F3N4O2. Mole weight: 356.35. Purity: >98%. IUPACName: 2-((1R,5S,6R)-3-(2-((S)-2-methylazetidin-1-yl)-6-(trifluoromethyl)pyrimidin-4-yl)-3-azabicyclo[3.1.0]hexan-6-yl)acetic acid. Canonical SMILES: O=C(C[C@@H]1[C@]2(CN(C[C@@]12[H])C3=NC(N4[C@H](CC4)C)=NC(C(F)(F)F)=C3)[H])O. Product ID: ACM2102501846. Alfa Chemistry ISO 9001:2015 Certified. Categories: Ketohexokinase inhibitor 1. | |
| PF-06840003 | PF-06840003 (EOS200271) is a highly selective, orally active and brain-penetrant IDO-1 inhibitor with IC50s of 0.41 ?M, 0.59 ?M, and 1.5 ?M for hIDO-1, dIDO-1, and mIDO-1, respectively[1][2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EOS200271. CAS No. 198474-05-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101111. | |
| PF-06869206 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06873600 | PF-06873600 Inhibitor. Uses: Scientific use. Product Category: T8463. CAS No. 2185857-97-8. |  |
| PF-06873600 | Ebvaciclib, also known as PF-06873600, is an orally bioavailable, cyclin-dependent kinase (CDK) inhibitor, with potential antineoplastic activity. Upon administration, PF-06873600 selectively targets, binds to and inhibits the activity of CDKs. Inhibition of these kinases leads to cell cycle arrest, induction of apoptosis and inhibition of tumor cell proliferation. CDKs, ATP-dependent serine/threonine kinases that are important regulators of cell cycle progression and cellular proliferation, are frequently overexpressed in tumor cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ebvaciclib; PF-06873600; PF 06873600; PF06873600. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2185857-97-8. Molecular formula: C20H27F2N5O4S. Mole weight: 471.52. Purity: >98%. IUPACName: Pyrido[2,3-d]pyrimidin-7(8H)-one, 6-(difluoromethyl)-8-[(1R,2R)-2-hydroxy-2-methylcyclopentyl]-2-[[1-(methylsulfonyl)-4-piperidinyl]amino]-. Canonical SMILES: O=C1C(C(F)F)=CC2=CN=C(NC3CCN(S(=O)(C)=O)CC3)N=C2N1[C@H]4[C@](C)(O)CCC4. Product ID: ACM2185857978. Alfa Chemistry ISO 9001:2015 Certified. | |
| PF-06928215 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| PF-06928215 | PF-06928215 is a cGAS (cyclic GMP-AMP Synthase) inhibitor with an IC50 of 4.9 ??. PF-06928215 has a high binding affinity of 0.2 ?M (Kd)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2378173-15-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-114182. | |
| PF-06939999 | PF-06939999 (PRMT5-IN-3) is a PRMT5 inhibitor that exhibits synthetic lethality to tumor cells but produce few side effects combined with DNA damaging agents. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PRMT5-IN-3. CAS No. 2159123-14-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-131493. | |
| PF-06952229 | PF-06952229 is a potent, selective and orally active TGFbR1 inhibitor. PF-06952229 specifically binds to TGFbR1 and prevents TGFbR1-mediated signal transduction. PF-06952229 is a promising antineoplastic agent for the study solid tumors, especifically metastatic breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1801333-55-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136244. | |
| PF-07258669 | PF-07258669 is a melanocortin-4 receptor (MC4) antagonist. PF-07258669 can be used for the research of cachexia, anorexia, or anorexia nervosa [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2755890-53-8. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148349. | |
| PF-07265807 | PF-07265807 is a potent TAM and c-Met kinase inhibitor with IC 50 values of 6.1 nM, 13.2 nM and 21.6 nM for AXL, MER and TYRO3, respectively. PF-07265807 can be used for researching anticancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2412356-57-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147218. | |
| PF-07284892 | PF-07284892 (ARRY-558) is a potent and orally active SHP2 inhibitor with an IC 50 value of 21 nM. PF-07284892 decreases the expression of pERK [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ARRY-558. CAS No. 2498597-94-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-153740. | |
| PF-07321332 | Nirmatrelvir, also known as PF-07321332 (brand name: Paxlovid), is an orally bioavailable 3C-like protease (3CLPRO) inhibitor and SARS-CoV-2 Mpro inhibitor. This drug is being investigated for safety, tolerability, and pharmacokinetics before moving on to studies of efficacy in the treatment or prophylaxis of COVID-19. 3CLPRO is responsible for cleaving polyproteins 1a and 1ab of SARS-CoV-2. PF-07321332 is an oral COVID-19 antiviral clinical candidate. By inhibiting the main protease, PF-07321332 prevents the virus from cleaving long protein chains into the parts it needs to reproduce itself. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nirmatrelvir; PF-07321332; PF 07321332; PF07321332; brand name Paxlovid. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2628280-40-8. Molecular formula: C23H32F3N5O4. Mole weight: 499.54. Purity: >98%. IUPACName: (1R,2S,5S)-N-((S)-1-cyano-2-((S)-2-oxopyrrolidin-3-yl)ethyl)-3-((S)-3,3-dimethyl-2-(2,2,2-trifluoroacetamido)butanoyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxamide. Canonical SMILES: [H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C#N)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C. Product ID: ACM2628280408. Alfa Chemistry ISO 9001:2015 Certified. | |
| PF-07328948 | PF-07328948 is an orally effective BDK (branch chain ketoacid dehydrogenase kinase) inhibitor, with IC50 of 110 nM. PF-07328948 acts as a BCKDH (branch chain ketoacid dehydrogenase) enzyme complex degrader to enhance BCAA (branch chain amino acid) catabolism. PF-07328948 improves metabolic and heart failure end points in rats[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2936625-34-0. Pack Sizes: 1 mg; 5 mg. Product ID: HY-159648. | |
| PF 1018 | PF1018 is an insecticidal agent isolated from the culture broth of Humicola sp. PF1018. Synonyms: Antibiotic PF 1018; PF1018. CAS No. 131256-42-3. Molecular formula: C28H35NO3. Mole weight: 433.6. |  |
| PF 1022A | PF1022A, an anthelmintic cyclodepsipeptide isolated from cultured mycelia of Mycelia Sterilia, has very good anthelmintic activity against Heligmosomoides polygyrus and Heterakis spumosa at 50 mg/kg. It has potent repellant activity against Ascaridiagalli in chicken. In vitro, it has activity against Trichinella spiralis and Nippostrongylus brasiliensis. Synonyms: PF1022A; PF-1022A; cyclo[N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe-N(Me)Leu-D-OAla-N(Me)Leu-D-OPhe]; cyclo[N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl-N-methyl-L-leucyl-N-oxa-D-alanyl-N-methyl-L-leucyl-N-oxa-D-phenylalanyl]; Cyclo[(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl-(αR)-α-hydroxybenzenepropanoyl-N-methyl-L-leucyl-(2R)-2-hydroxypropanoyl-N-methyl-L-leucyl]. Grade: 98%. CAS No. 133413-70-4. Molecular formula: C52H76N4O12. Mole weight: 949.18. | |
| PF-1057A | PF-1057A is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057A; PF1057A. CAS No. 89162-70-9. Molecular formula: C31H56O10S2. Mole weight: 652.9. | |
| PF-1057B | PF-1057B is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057B; PF1057B. CAS No. 89020-47-3. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
| PF-1057C | PF-1057C is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057C; PF1057C. CAS No. 89020-48-4. Molecular formula: C35H60O12S2. Mole weight: 737. | |
| PF-1057D | PF-1057D is an antibiotic produced by Chaetomella cinnamomea PF-1057. Synonyms: PF 1057D; PF1057D. Molecular formula: C33H58O11S2. Mole weight: 694.9. | |
| PF-1092A | PF-1092A is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 3.0 x 10 nM. Synonyms: PF 1092A; PF1092A. Molecular formula: C17H20O5. Mole weight: 304.34. | |
| PF-1092B | PF-1092B is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(2) nM. Synonyms: PF 1092B; PF1092B. Molecular formula: C17H20O5. Mole weight: 304.34. | |
| PF-1092C | PF-1092C is a nonsteroidal progesterone receptor ligand produced by Penicillium oblatum. It was shown to competitively inhibit [3H]-progesterone binding to porcine uteri cytosol preparations with IC50 of 2.2 x 10(3) nM. Synonyms: PF 1092C; PF1092C. Molecular formula: C15H18O4. Mole weight: 262.3. | |
| PF-1163A | PF-1163A is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: (3S,10R,13S)-3-[[4-(2-Hydroxyethoxy)phenyl]methyl]-13-[(2S)-2-hydroxypentyl]-4,10-dimethyl-1-oxa-4-azacyclotridecane-2,5-dione. Grade: ≥95%. CAS No. 258871-59-9. Molecular formula: C27H43NO6. Mole weight: 477.6. | |
| PF-1163B | PF-1163B is an antibiotic isolated from Penicillium species. It exhibits growth inhibitory activity against pathogenic fungal strain Candida albicans and inhibits the ergosterol biosynthesis in Candida albicans. Synonyms: Antibiotic PF-1163B; (-)-PF 1163B; 3S-[[4-(2-hydroxyethoxy)phenyl]methyl]-4,10R-dimethyl-13R-pentyl-1-oxa-4-azacyclotridecane-2,5-dione. Grade: ≥95%. CAS No. 258871-60-2. Molecular formula: C27H43NO5. Mole weight: 461.63. | |
| PF-1355 | PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor, used for treatment of vasculitic diseases. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-06281355. CAS No. 1435467-38-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100873. | |
| Pf 184 | Pf 184. Uses: Designed for use in research and industrial production. Additional or Alternative Names: PF 184, NCGC00263213-01, FT-0673646, 1187460-81-6, 8-[[[5-Chloro-2-[3,4-dimethyl-3,4-bis(hydroxymethyl)-1-pyrrolidinyl]-4-pyridinyl]carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydro-1H-benz[g]indazole-3-carboxamide. Product Category: Heterocyclic Organic Compound. CAS No. 1187460-81-6. Molecular formula: C32H32ClFN6O4. Mole weight: C32H32ClFN6O4. Purity: >98 %. IUPACName: 8-[[2-[(3S,4R)-3,4-bis(hydroxymethyl)-3,4-dimethylpyrrolidin-1-yl]-5-chloropyridine-4-carbonyl]amino]-1-(4-fluorophenyl)-4,5-dihydrobenzo[g]indazole-3-carboxamide. Canonical SMILES: CC1(CN(CC1(C)CO)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl)CO. Product ID: ACM1187460816. Alfa Chemistry ISO 9001:2015 Certified. Categories: PF-184563. | |
| PF184 | PF184. CAS No: 1187460-81-6 |  Sarchem Laboratories New Jersey NJ |
| PF 184 | PF 184 is a potent and selective IKK-2 inhibitor (IC50 = 37 nM). Displays selectivity over 85 other kinases. Inhibits IL-1 β-induced TNF-α in a steroid-insensitive in vitro model of oxidative stress. Group: Biochemicals. Alternative Names: 8- [ [ [5-Chloro-2- [3, 4-dimethyl-3, 4-bis (hydroxymethyl) -1-pyrrolidinyl] -4-pyridinyl] carbonyl] amino] -1- (4-fluorophenyl) -4, 5-dihydro-1H-benz [g] indazole-3-carboxamide. Grades: Highly Purified. CAS No. 1187460-81-6. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| PF-2545920 hydrochloride | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
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