A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Pilose Asiabell Root Extract. Applications: Used for health care products, dietary supplements, herb medecine as nourishing tonic. Group: Others. Synonyms: Pilose Asiabell Root Extract; Radix Codonopsis L. Purity: 10:1 by TLC. Appearance: Brown-yellow fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Rhizoma. Species: Radix Codonopsis L. Pilose Asiabell Root Extract; Radix Codonopsis L.; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-143.
Pilosulin 1
Pilosulin 1 is an antimicrobial peptide found in venom of Myrmecia pilosula (Jack jumper ant). It has anti-gram-positive bacteria, gram-negative bacteria, Fungi and Mammalian cells activity. Grade: ≥96%.
Pilosulin 2
Pilosulin 2 is an antimicrobial peptide found in Myrmecia pilosula (venom, Australia), and has antimicrobial activity. Synonyms: H-Ile-Asp-Trp-Lys-Lys-Val-Asp-Trp-Lys-Lys-Val-Ser-Lys-Lys-Thr-Cys-Lys-Val-Met-Leu-Lys-Ala-Cys-Lys-Phe-Leu-Gly-OH (Disulfide bridge: Cys16-Cys23). Grade: ≥97%. Molecular formula: C149H246N38O34S3. Mole weight: 3210.02.
Pilosulin 3
Pilosulin 3 is an antimicrobial peptide found in Myrmecia banksi (venom, Australia), and has antibacterial activity against gram-negative bacteria Escherichia coli (MIC<25 μM) and gram-positive bacteria Staphylococcus aureus (MIC<25 μM), Bacillus subtilis (MIC<50 μM). Synonyms: H-Ile-Ile-Gly-Leu-Val-Ser-Lys-Gly-Thr-Cys-Val-Leu-Val-Lys-Thr-Val-Cys-Lys-Lys-Val-Leu-Lys-Gln-Gly-OH (Disulfide bridge: Cys10-Cys17). Grade: ≥97%. Molecular formula: C113H206N30O29S2. Mole weight: 2513.19.
Pilosulin 4
Pilosulin 4 is an antimicrobial peptide found in Myrmecia banksi (Jack jumper ant), and has antibacterial activity against gram-negative bacteria Escherichia coli (MIC<6.25 μM), Pseudomonas aeruginosa (MIC<25 μM) and gram-positive bacteria Staphylococcus aureus (MIC<6.25 μM), Bacillus subtilis (MIC<50 μM). Synonyms: H-Phe-Asp-Ile-Thr-Lys-Leu-Asn-Ile-Lys-Lys-Leu-Thr-Lys-Ala-Thr-Cys-Lys-Val-Ile-Ser-Lys-Gly-Ala-Ser-Met-Cys-Lys-Val-Leu-Phe-Asp-Lys-Lys-Lys-Gln-Glu-OH (Disulfide bridge: Cys16-Cys26). Grade: ≥97%. Molecular formula: C183H316N48O50S3. Mole weight: 4085.01.
Pilosulin 5
Pilosulin 5 is an antimicrobial peptide found in Myrmecia pilosula (Jack jumper ant, venom, Australia), and has antimicrobial activity. Synonyms: Asp-Val-Lys-Gly-Met-Lys-Lys-Ala-Ile-Lys-Gly-Ile-Leu-Asp-Cys-Val-Ile-Glu-Lys-Gly-Tyr-Asp-Lys-Leu-Ala-Ala-Lys-Leu-Lys-Lys-Val-Ile-Gln-Gln-Leu-Trp-Glu. Grade: ≥95%. Molecular formula: C192H327N49O51S2. Mole weight: 4202.14.
Pilsicainide hydrochloride
Pilsicainide hydrochloride (SUN-1165) is an orally active sodium channel blocker and potent class Ic antiarrhythmic agent [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: SUN-1165; Pilzicainide(hydrochloride). CAS No. 88069-49-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-101245.
Pim1/AKK1-IN-1 is a potent multi-kinase inhibitor with Kd values of 35 nM/53 nM/75 nM/380 nM for Pim1/AKK1/MST2/LKB1 respectively, and also inhibits MPSK1 and TNIK. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LKB1/AAK1 dual inhibitor. CAS No. 1093222-27-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-10371.
PIM1-IN-1
PIM1-IN-1 is a potent and highly selective PIM1/3 inhibitor, with IC 50 s of 7, 5530 and 70 nM for PIM1, PIM2, and PIM3, respectively, inhibits the phosphorylation of BAD, a downstream target of PIM, with an EC 50 of 262 nM. PIM1-IN-1 shows no obvious effect on FLT3 or hERG binding. Antiproliferative and anti-cancer activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1417630-95-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-111552.
PIM-1 Inhibitor 2
PIM-1 Inhibitor 2. Group: Biochemicals. Grades: Purified. CAS No. 477845-12-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
A cell-permeable hydroxyphenyl-propylidene-benzohydrazide compound that acts as a potent, ATP-competitive (Ki = 0.3uM), and highly isoform-selective PIM inhibitor (IC50 = 2.5, 2.5, and 0.047uM against PIM1, PIM2, and PIM3, respectively; [ATP] = 10uM), while affecting CK2alpha2 only at much higher concentrations (IC50 = 5uM, [ATP] = 10uM) and exhibiting little or no activity against a panel of 258 other kinases (<40% inhibition at 5uM). Shown to inhibit PIM3-dependent STAT3 Tyr705 phosphorylation in DU-145 prostate cancer and MiaPaCa2 pancreatic cancer cells (by 73% and 83%, respectively; 10uM for 18h), while displaying little effect toward STAT3 Tyr694 phosphoylation in 22RV1 cultures. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
PIM447
PIM447 (LGH447) is a potent, orally available, and selective pan- PIM kinase inhibitor, with K i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 displays dual antimyeloma and bone-protective effects. PIM447 induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LGH447. CAS No. 1210608-43-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-19322.
PIM-447 dihydrochloride
PIM447 dihydrochloride (LGH447 dihydrochloride) is a potent, orally available, and selective pan- PIM kinase inhibitor, with K i values of 6, 18, and 9 pM for PIM1, PIM2, and PIM3, respectively. PIM447 dihydrochloride displays dual antimyeloma and bone-protective effects. PIM447 dihydrochloride induces apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LGH447 dihydrochloride. CAS No. 1820565-69-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-19322B.
pimaradiene synthase
Isolated from the plants Pinus banksiana (jack pine) and Pinus contorta (lodgepole pine). Group: Enzymes. Synonyms: PbmPIM1; PcmPIM1. Enzyme Commission Number: EC 4.2.3.147. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5161; pimaradiene synthase; EC 4.2.3.147; PbmPIM1; PcmPIM1. Cat No: EXWM-5161.
Pimaric
Pimaric. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 13α-Methyl-13-vinylpodocarp-8(14)-en-15-oic acid. Product Category: Chlorinated Phenol and Resin Acids Standards. CAS No. 127-27-5. Molecular formula: C20H30O2. Mole weight: 302.45. Purity: 75-90%. Product ID: ACM127275-1. Alfa Chemistry ISO 9001:2015 Certified. Categories: Pimaric acid.
from Streptomyces chattanoogensis, ?95% (HPLC). Group: Pesticides & metabolites standardspharma & vet compounds & metabolitesstandards for environmental regulatory methodspharma & vet compounds & metabolites. Alternative Names: Natamax lactose, 6,11,28-Trioxatricyclo[22.3.1.05,7]octacosane, pimaricin deriv., Myprozine,6,11,28-Trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, 22-[(3-amino-3,6-dideoxy-?-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-, (1R,3S,5R,7R,8E,12R,14E,16E,18E,20E,22R,24S,25R,26S)-, [1R-(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-22-[(3-Amino-3,6-dideoxy-?-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-6,11,28-trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, Antibiotic A 5283, Delvocid, Pimaricin (6CI,8CI), 6,11,28-Trioxatricyclo[22.3.1.05,7]octacosa-8,14,16,18,20-pentaene-25-carboxylic acid, 22-[(3-amino-3,6-dideoxy-?-D-mannopyranosyl)oxy]-1,3,26-trihydroxy-12-methyl-10-oxo-, [1R-(1R*,3S*,5R*,7R*,8E,12R*,14E,16E,18E,20E,22R*,24S*,25R*,26S*)]-, CL 12625, Natacyn, Natamax, Pimafucin, Natamax SF, Natajen, Natamycin, E 235, Synogil, Mycophyt, Myuprozine, ?-Natamycin, Tennecetin (7CI).
Pimaricin
It is produced by the strain of Str. natalensis NRRL 2651, Str. gilvosporeus. It's a polyene macrolide antibiotic with strong antifungal effect. Synonyms: Myprozine; Natamycin; Delvolan; Delvocid; Natacyn; Natafucin; Pimafucin; Pimafugin; Tennecetin; Synogil; Antibiotic A-5283; Natamicina; 16-(3-Amino-3,6-didesoxy-beta-D-mannopyranosyloxy)-5,6-epoxy-8,12,14-trihydroxy-26-methyl-2,10-dioxo-1-oxacyclohexacosa-3,17,19,21,23-pentaen-13-carbonsaeure. Grade: ≥98%. CAS No. 7681-93-8. Molecular formula: C33H47NO13. Mole weight: 665.73.
Pimasertib
Pimasertib (AS703026) is a highly selective, ATP non-competitive allosteric orally available MEK1/2 inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AS703026; MSC1936369B. CAS No. 1236699-92-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12042.
Pimavanserin
Pimavanserin is a selective inverse agonist of the 5-HT2A receptor with pIC 50 and pK d of 8.73 and 9.3, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACP-103. CAS No. 706779-91-1. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14557.
Pimavanserin-[d4], is the labelled analogue of Pimavanserin, which is an atypical antipsychotic. Synonyms: Pimavanserin-d4; Pimavanserin d4. Molecular formula: C25H30D4FN3O2. Mole weight: 431.59.
Pimavanserin hemitartrate
Pimavanserin (ACP-103) hemitartrate is a potent 5-HT 2A receptor inverse agonist with pIC 50 and pK i of 8.73 and 9.3, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ACP-103 hemitartrate. CAS No. 706782-28-7. Pack Sizes: 10 mM * 1 mL; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14557A.
Pimavanserin Impurity 18
Pimavanserin Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 107456-06-4. Molecular formula: C14H15NO2. Mole weight: 229.28. Catalog: APB107456064.
Pimavanserin Impurity 2
Pimavanserin Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 134227-41-1. Molecular formula: C14H13F2N. Mole weight: 233.26. Catalog: APB134227411.
Pimavanserin Impurity 20
Pimavanserin Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1134815-53-4. Molecular formula: C21H26FN3O2. Mole weight: 371.46. Catalog: APB1134815534.
Pimavanserin Impurity 24
Pimavanserin Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1246458-13-8. Molecular formula: C25H32FN3O2. Mole weight: 425.55. Catalog: APB1246458138.
Pimavanserin Impurity 33
Pimavanserin Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133067-71-7. Molecular formula: C8H10Cl2N2S. Mole weight: 237.14. Catalog: APB133067717.
Pimavanserin Impurity 42
Pimavanserin Impurity 42. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1080491-31-1. Molecular formula: C29H40FN3O8. Mole weight: 577.65. Catalog: APB1080491311.
Pimavanserin N-Oxide
Pimavanserin N-Oxide. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1134815-71-6. Molecular formula: C25H34FN3O3. Mole weight: 443.55. Catalog: APB1134815716.
Pimavanserin Tartrate
Pimavanserin tartrate is a tartrate salt that is the hemitartrate salt of pimavanserin. An atypical antipsychotic that is used for treatment of hallucinations and delusions associated with Parkinson's disease. It has a role as an antipsychotic agent, a serotonergic antagonist and a 5-hydroxytryptamine 2A receptor inverse agonist. It contains a pimavanserin(1+). Alternative Names: Nuplazid. UNII-NA83F1SJSR. ACP-103. CAS No. 706782-28-7. Product ID: CHE706782287. Molecular formula: C54H74F2N6O10. Mole weight: 1005.2. EINECS: 810-275-6. SMILES: CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.CC(C)COC1=CC=C(C=C1)CNC(=O)N(CC2=CC=C(C=C2)F)C3CCN(CC3)C.[C@@H]([C@H](C(=O)O)O)(C(=O)O)O. Category: Pipeline Products.
Pimecrolimus
Pimecrolimus is an immunomodulator of calcineurin inhibitors produced by Streptomyces. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: 33-epi-Chloro-33-desoxyascomycin; ASM-981; ASM981; ASM 981; SDZ ASM 981; SDZ-ASM 981; SDZ-ASM-981. Grade: >98%. CAS No. 137071-32-0. Molecular formula: C43H68ClNO11. Mole weight: 810.45.
Pimecrolimus
Pimecrolimus (SDZ-ASM 981) is a potent, nonsteroid and orally active calcineurin inhibitor with a K i of 117 nM. Pimecrolimus shows anti-inflammatory activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SDZ-ASM 981. CAS No. 137071-32-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-13723.
Pimecrolimus
Macrolactam ascomycin derivative; inhibits production of pro-inflammatory cytokines by T cells and mast cells. Immunosuppresant. Group: Biochemicals. Alternative Names: 33-Epichloro-33-desoxyascomycin; 33-epi-Chloro-33-desoxyascomycin; ASM 981; Elidel; Picrolimus; SDZ-ASM 981. Grades: Highly Purified. CAS No. 137071-32-0. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C43H68ClNO11, Melting Point: 142-144°C. US Biological Life Sciences.
Pimecrolimus, a rapamycin (sirolimus) derivative, is a cell-selective inhibitor of inflammatory cytokines developed for the treatment of inflammatory skin diseases, such as allergic contact dermatitis, atopic dermatitis, plaque-type psoriasis, and irritant contact dermatitis. It reduces the production of inflammatory cytokines in T cells and mast cells and inhibits the release of preformed inflammatory mediators from mast cells. Group: Biochemicals. Grades: Highly Purified. CAS No. 137071-32-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Pimecrolimus impurity 2
Pimecrolimus impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1025113-89-6. Molecular formula: C42H66ClNO11. Mole weight: 796.44. Catalog: APB1025113896.
Pimelic acid
Pimelic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 111-16-0. Pack Sizes: 50g, 100g, 250g, 500g, 1kg. Molecular Formula: C7H12O4. US Biological Life Sciences.
Worldwide
Pimelic acid
Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Heptanedioic acid; 1,5-Pentanedicarboxylic acid; 1,7-Heptanedioic acid. CAS No. 111-16-0. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-Y1139.
Pimelic acid 99+%
Pimelic acid 99+%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 111-16-0. Pack Sizes: 100g, 250g, 1Kg. US Biological Life Sciences.
Worldwide
Pimelic Acid-[d4]
Pimelic Acid-[d4]. Synonyms: Pimelic Acid D4. Grade: 98% atom D. CAS No. 19031-56-2. Molecular formula: C7H8D4O4. Mole weight: 164.19.
A heme-thiolate protein (P-450). The enzyme catalyses an oxidative C-C bond cleavage of long-chain acyl-[acyl-carrier protein]s of various lengths to generate pimeloyl-[acyl-carrier protein], an intermediate in the biosynthesis of biotin. The preferred substrate of the enzyme from the bacterium Bacillus subtilis is palmitoyl-[acyl-carrier protein] which then gives heptanal as the alkanal. The mechanism is similar to EC 1.14.15.6, cholesterol monooxygenase (side-chain-cleaving), followed by a hydroxylation step, which may occur spontaneously. Group: Enzymes. Synonyms: bioI (gene name); P450BioI; CYP107H1. Enzyme Commission Number: EC 1.14.15.12. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0937; pimeloyl-[acyl-carrier protein] synthase; EC 1.14.15.12; bioI (gene name); P450BioI; CYP107H1. Cat No: EXWM-0937.
Pimeloyl-CoA
Pimeloyl-CoA is a biotin precursor of Escherichia coli. Pimeloyl-CoA can be used for the research of the pathway of de novo biotin biosynthesis in Escherichia coli [1]. Uses: Scientific research. Group: Natural products. CAS No. 18907-20-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-142080.
pimeloyl-CoA dehydrogenase
Involved in the benzoate degradation (anaerobic) pathway in bacteria. Group: Enzymes. Enzyme Commission Number: EC 1.3.1.62. CAS No. 276682-23-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1331; pimeloyl-CoA dehydrogenase; EC 1.3.1.62; 276682-23-6. Cat No: EXWM-1331.
Involved in biotin biosynthesis in Gram-negative bacteria. The enzyme exhibits carboxylesterase activity, particularly toward substrates with short acyl chains. Even though the enzyme can interact with coenzyme A thioesters, the in vivo role of the enzyme is to hydrolyse the methyl ester of pimeloyl-[acyl carrier protein], terminating the part of the biotin biosynthesis pathway that is catalysed by the fatty acid elongation enzymes. Group: Enzymes. Synonyms: BioH. Enzyme Commission Number: EC 3.1.1.85. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3514; pimelyl-[acyl-carrier protein] methyl ester esterase; EC 3.1.1.85; BioH. Cat No: EXWM-3514.
Pimento Leaf Oil WONF. CAS No. MIXTURE. Kosher: Y. VIGON Item # 500327. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Pimethixene maleate
Pimethixene maleate is antihistamine and antiserotonergic compound, acts as an antimigraine agent. Pimethixene maleate is a highly potent antagonist of 5-HT 1A , 5-HT 2A , 5-HT 2B , 5-HT 2C , histamine H 1 , dopamine D 2 and D 4.4 as well as muscarinic M 1 and M 2 receptors, with pK i s of 7.63, 10.22, 10.44, 8.42, 10.14, 8.19, 7.54, 8.61 and 9.38, respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Pimetixene maleate. CAS No. 13187-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-B1101A.
Pimicotinib
Pimicotinib is a CSF1R inhibitor with antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ABSK021. CAS No. 2253123-16-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153920.
Piminodine dihydrochloride
Piminodine dihydrochloride. Group: Biochemicals. Alternative Names: 4-Phenyl-1-[3-(phenylamino)propyl]-4-piperidinecarboxylic acid ethyl ester hydrochloride; 1-(3-Anilinopropyl)-4-phenylisonipecotic acid ethyl ester dihydrochloride; Anopridine dihydrochloride. Grades: Highly Purified. CAS No. 113862-30-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C23H32Cl2N2O2. US Biological Life Sciences.
Worldwide
Pimitespib
Pimitespib (TAS-116) is an oral bioavailable, ATP-competitive, highly specific HSP90α/HSP90β inhibitor ( K i s of 34.7 nM and 21.3 nM, respectively) without inhibiting other HSP90 family proteins such as GRP94 [1]. Pimitespib demonstrates less ocular toxicity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TAS-116. CAS No. 1260533-36-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15785.
A cell-permeable imidazopyridazine compound that acts as a potent, reversible and ATP-competitive inhibitor of Pim-1,2,3, Flt-3 and haspin kinase activities (IC50=7, 363, 69, 44 and 34nM, respectively) with moderate (40% inhibition at 1uM for c-kit) to excellent selectivity over CDKs, Aurora, Chk1, IKK, JNK, Abl, Raf, PKA, PKC and PI 3-K among 300-kinases. Shown to inhibit RNA synthesis, block phosphorylation of c-Myc-Ser62 and STAT3-Tyr705, and decrease c-Myc and Mcl-1 protein levels; cause cell cycle arrest and induce apoptosis in CLL lymphocytes and in AML cells, and efficiently arrest the growth of several prostate cancer cells (IC50 <10uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??F?N?O; 2H?SO?, Molecular Weight: 601.6. US Biological Life Sciences.
The human p27Kip1 C-terminus PIM-1 phosphorylation site- (Thr198) containing sequence is synthesized with an N-terminal Arg octamer/R8-containing sequence to facilitate its use as a cell-permeable, substrate-competitive PIM-1 inhibitor. Reported to completely prevents human prostate carcinoma DU145-derived tumor expansion for up to 17 days (0.5umol/animal on days 0 & 5; intratumoral injection) in mice in vivo when combined with a single Taxol dosage on day zero (60mg/kg; i.p.). Studies using FITC-conjugated R8-T198wt demonstrate that R8-T198wt-induced cell cycle arrest and apoptosis in PIM-1-expressing DU145 cells are direct consequences of inhibition of PIM-1-mediated p27Kip1 Thr198 and Bad Ser112 phosphorylation, respectively. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Pimobendan. Group: Biochemicals. Grades: Highly Purified. CAS No. 74150-27-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. US Biological Life Sciences.
Worldwide
Pimobendan
Pimobendan (UD-CG115) is a selective inhibitor of PDE3 with IC 50 of 0.32 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: UD-CG115. CAS No. 74150-27-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-B0204.
Pimobenden
100mg Pack Size. Group: Bioactive Small Molecules. Formula: C19H18N4O2. CAS No. 74150-27-9. Prepack ID 69675966-100mg. Molecular Weight 334.37. See USA prepack pricing.
Pimodivir
Pimodivir (VX-787) is an orally bioavailable inhibitor of influenza A virus polymerases through interaction with the viral PB2 subunit. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-787. CAS No. 1629869-44-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12353A.
Pimonidazole
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor [1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70132-50-2. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-105129A.
Pimonidazole is a novel hypoxia marker for complementary study of tumor hypoxia and cell proliferation in tumor [1]. Pimonidazole accumulates in hypoxic cells via covalent binding with macromolecules or by forming reductive metabolites after reduction of its nitro group, it can be used for qualitative and quantitative assessment of tumor hypoxia [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 70132-51-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-105129.
Pimozide
Pimozide is a dopamine receptor antagonist, with K i s of 1.4 nM, 2.5 nM and 588 nM for dopamine D2, D3 and D1 receptors, respectively, and also has affinity at α1-adrenoceptor , with a K i of 39 nM; Pimozide also inhibits STAT3 and STAT5. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R6238. CAS No. 2062-78-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-12987.