A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Sitafloxacin, a new-generation, broad-spectrum oral fluoroquinolone that is very active against many Gram-positive, Gram-negative and anaerobic clinical isolates, including strains resistant to other fluoroquinolones, was recently approved in Japan for the treatment of respiratory and urinary tract infections. In terms of clinical efficacy, oral sitafloxacin was noninferior to oral levofloxacin in the treatment of community-acquired pneumonia or an infectious exacerbation of chronic respiratory tract disease, noninferior to oral tosufloxacin in the treatment of community-acquired pneumonia, and noninferior to oral levofloxacin in the treatment of complicated urinary tract infections, according to the results of randomized, double-blind, multicentre, noninferiority trials. Noncomparative studies demonstrated the efficacy of oral sitafloxacin in otorhinolaryngological infections, urethritis in men, C. trachomatis-associated cervicitis in women and odontogenic infections. Synonyms: 7-((S)-7-amino-5-azaspiro[24]heptan-5-yl)-8-chloro-6-fluoro-1-((1R,2S)-2-fluorocyclopropyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid; DU 6859; DU-6859; DU6859; DU 6859A; DU-6859A; DU6859A; Sitafloxacin; Sitafloxacin hydrate, Sitafloxacin anhydrous, Trade name: Gracevit. Grade: >98%. CAS No. 127254-12-0. Molecular formula: C19H18ClF2N3O3. Mole weight: 409.81.
Sitafloxacin
Sitafloxacin (DU6859a) is a potent, orally active fluoroquinolone antibiotic. Sitafloxacin shows antichlamydial activity and antibacterial activities against a broad range of gram-positive and gram-negative bacteria, including anaerobic bacteria, as well as against atypical pathogens. Sitafloxacin can be used for the research of respiratory tract infection and urinary tract infection [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DU6859a. CAS No. 127254-12-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-B0395.
Sitafloxacin hydrate
Sitafloxacin (DU6859a) hydrate is an orally active fluoroquinolone antibiotic ( antibiotic ) with in vitro activity against a wide range of Gram-positive and -negative bacteria, including anaerobic bacteria, as well as atypical pathogens. Sitafloxacin is used in the study of respiratory tract infections and urinary tract infections [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DU6859a hydrate. CAS No. 163253-35-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0395C.
Sitafloxacin Impurity 27
Sitafloxacin Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 101513-77-3. Molecular formula: C7H2ClF3O2. Mole weight: 210.54. Catalog: APB101513773.
Sitafloxacin isomer II
Sitafloxacin isomer II. Group: Biochemicals. Grades: Highly Purified. CAS No. 127199-06-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. US Biological Life Sciences.
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Sitafloxacin isomer I (SSR)
Sitafloxacin isomer I (SSR). Group: Biochemicals. Grades: Highly Purified. CAS No. 127254-11-9. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. US Biological Life Sciences.
Worldwide
Sitafloxacin Sesquihydrate
Antibacterial. Group: Biochemicals. Alternative Names: 7-[(7S)-7-Amino-5-azaspiro[2.4]hept-5-yl]-8-chloro-6-fluoro-1-[(1R,2S)-2-fluorocyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic Acid Hydrate. Grades: Highly Purified. CAS No. 163253-35-8. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Sitagliptin
Sitagliptin (MK 0431) is a potent inhibitor of DPP4 with IC50 of 19 nM in Caco-2 cell extracts. Sitagliptin is used as a hypoglycemic agent to treat type 2 diabetes. Uses: The treatment of type 2 diabetes. Synonyms: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine; MK0431; Xelevia; Januvia; Tesavel; NSC813215; (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-1-butanone; 1,2,4-triazolo[4,3-a]pyrazine-7(8H)-propanamine, 5,6-dihydro-γ-oxo-3-(trifluoromethyl)-α-[(2,4,5-trifluorophenyl)methyl]-, (αR)-. Grade: >98%. CAS No. 486460-32-6. Molecular formula: C16H15N5OF6. Mole weight: 407.31.
Sitagliptin
Sitagliptin (MK-0431) is a potent and orally active inhibitor of DPP4 with an IC 50 of 19 nM in Caco-2 cell extracts [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0431. CAS No. 486460-32-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-13749.
Sitagliptin
Sitagliptin. Group: Biochemicals. Alternative Names: (3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4- triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one. Grades: Highly Purified. CAS No. 486460-32-6. Pack Sizes: 5g, 10g, 25g. Molecular Formula: C16H15F6N5O, Molecular Weight: 407.31. US Biological Life Sciences.
Worldwide
Sitagliptin Carbamoyl β-D-Glucuronide
A metabolite of Sitagliptin. Group: Biochemicals. Alternative Names: 1- [N- [ (1R) -3- [5, 6-Dihydro-3- (trifluoromethyl) -1, 2, 4-triazolo [4, 3-a] pyrazin-7 (8H) -yl] -3-oxo-1- [ (2, 4, 5-trifluorophenyl) methyl] propyl] carbamate] . Grades: Highly Purified. CAS No. 940002-59-5. Pack Sizes: 1mg. US Biological Life Sciences.
An isotope labelled Sitagliptin. Sitagliptin, marketed as the phosphate salt, is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: (3R)-3-amino-1-[3-(trifluoromethyl)(5,5,6,6-D4)-5H,6H,7H,8H-[1,2,4]triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one; (R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine D4. Grade: >98%. CAS No. 1426173-93-4. Molecular formula: C16H11D4F6N5O. Mole weight: 411.34.
Sitagliptin-d4 phosphate
Sitagliptin-d 4 (phosphate) is the deuterium labeled Sitagliptin phosphate. Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC50 of 19 nM in Caco-2 cell extracts[1][2]. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1432063-88-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-13749AS.
Sitagliptin-d4 Phosphate
A trizolopyrazine dipeptidyl peptidase IV inhibitor. It has recently been approved for the therapy of type II diabetes. Group: Biochemicals. Alternative Names: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-d4 Phosphate; Januvia-d4;MK 0431-d4. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Sitagliptin FP Impurity E Hydrochloride
Sitagliptin EP Impurity E is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Sitagliptin Impurity 17 HCl; Sitagliptin Acid Impurity HCl; (R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoic Acid Hydrochloride; (βR)-β-Amino-2,4,5-trifluorobenzenebutanoic Acid Hydrochloride. Grade: >95%. CAS No. 1204818-19-8. Molecular formula: C10H11ClF3NO2. Mole weight: 269.65.
Sitagliptin Impurity 04
Sitagliptin Impurity 04. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1675201-14-5. Molecular formula: C16H12F6N4O. Mole weight: 390.29. Catalog: APB1675201145.
Sitagliptin Impurity 05
Sitagliptin Impurity 05. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1253056-18-6. Molecular formula: C16H12F6N4O. Mole weight: 390.29. Catalog: APB1253056186.
Sitagliptin Impurity 09
Sitagliptin Impurity 09. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1253056-01-7. Molecular formula: C16H14F6N4O2. Mole weight: 408.3. Catalog: APB1253056017.
Sitagliptin Impurity 19
Sitagliptin Impurity 19 is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: (R)-Sitagliptin N-Boc-Acid Impurity; (R)-3-((tert-Butoxycarbonyl)amino)-4-(2,4,5-trifluorophenyl)butanoic Acid; Boc-(R)-3-amino-4-(2,4,5-trifluorophenyl)butanoic acid. Grade: >95%. CAS No. 486460-00-8. Molecular formula: C15H18F3NO4. Mole weight: 333.3.
Sitagliptin Impurity 21
Sitagliptin Impurity 21 is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: Boc-D-β-homophenylalanine; Boc-D-β-Homophe-OH; (R)-3-(Boc-amino)-4-phenylbutyric acid; N-β-(t-Butoxycarbonyl)-D-β-homophenylalanine. Grade: >97%. CAS No. 101555-61-7. Molecular formula: C15H21NO4. Mole weight: 279.33.
Sitagliptin Impurity 22
Sitagliptin Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1253055-94-5. Molecular formula: C19H20F3NO5. Mole weight: 399.37. Catalog: APB1253055945.
Sitagliptin Impurity 29
Sitagliptin Impurity 29. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1334244-28-8. Molecular formula: C16H16F5N5O. Mole weight: 389.33. Catalog: APB1334244288.
Sitagliptin Impurity 46
Sitagliptin Impurity 46. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1234321-81-3. Molecular formula: C13H12F3NO3. Mole weight: 287.24. Catalog: APB1234321813.
Sitagliptin Impurity 61
Sitagliptin Impurity 61. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1253055-92-3. Molecular formula: C11H12F3NO2. Mole weight: 247.22. Catalog: APB1253055923.
Sitagliptin Impurity 62
Sitagliptin Impurity 62. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1234321-83-5. Molecular formula: C13H14F3NO3. Mole weight: 289.25. Catalog: APB1234321835.
Sitagliptin Impurity 67
Sitagliptin Impurity 67. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1032506-99-2. Molecular formula: C11H10F2O3. Mole weight: 228.19. Catalog: APB1032506992.
Sitagliptin Impurity 74
Sitagliptin Impurity 74. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1256815-03-8. Molecular formula: C10H7F3O3. Mole weight: 232.16. Catalog: APB1256815038.
Sitagliptin phosphate is the phosphate salt form of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Uses: Hypoglycemic agents. Synonyms: (2R)-4-Oxo-4-(3-(trifluoromethyl)-5,6-dihydro(1,2,4)triazolo(4,3-a)pyrazin-7(8H)-yl)-1-(2,4,5-trifluorophenyl)butan-2-amine phosphate salt; MK-431; ONO-5435. Grade: >98%. CAS No. 654671-78-0. Molecular formula: C16H15F6N5O.H3O4P. Mole weight: 505.31.
Sitagliptin phosphate
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Sitagliptin phosphate
Sitagliptin phosphate (MK-0431 phosphate) is a potent inhibitor of DPP4 with an IC 50 of 19 nM in Caco-2 cell extracts [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0431 phosphate. CAS No. 654671-78-0. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-13749A.
Sitagliptin Phosphate
Sitagliptin is a trizolopyrazine dipeptidyl peptidase IV inhibitor. Sitagliptin has recently been approved for the therapy of type II diabetes. Group: Biochemicals. Alternative Names: 7-[(3R)-3-Amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl]-5,6,7,8-tetrahydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazine-phosphate. Grades: Highly Purified. CAS No. 654671-78-0. Pack Sizes: 250mg. US Biological Life Sciences.
Worldwide
Sitagliptin phosphate monohydrate
Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP4 with an IC 50 of 19 nM in Caco-2 cell extracts [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MK-0431 phosphate monohydrate. CAS No. 654671-77-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 200 mg. Product ID: HY-13749B.
An anti-diabetic (antihyperglycemic) drug of the dipeptidyl peptidase-4 (DPP-4) class. Inhibition of the enzyme DPP-4 is thought to increase Glucagon-like peptide-1 (GLP-1) which inhibits glucagon release, stimulates the insulin release and lowers blood glucose. Group: Biochemicals. Grades: Highly Purified. CAS No. 654671-77-9. Pack Sizes: 100mg. US Biological Life Sciences.
Worldwide
Sitagliptin Related Compound 1
Sitagliptin Related Compound 1 is an impurity of Sitagliptin. Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor for treatment of diabetes mellitus type 2. Synonyms: (R)-3-((tert-Butoxycarbonyl)amino)-4-(3-fluorophenyl)butanoic acid; Boc-(R)-3-amino-4-(3-fluorophenyl)-butyric acid. Grade: >95%. CAS No. 331763-66-7. Molecular formula: C15H20FNO4. Mole weight: 297.32.
Sitagliptin System Suitability Mixture
United States Pharmacopeia (USP) Reference Standard. Group: Pharmacopeia & metrological institutes standards.
Sitaxsentan sodium. Group: Biochemicals. Alternative Names: N-(4-Chloro-3-methyl-5-isoxazolyl)-2-[2-(6-methyl-1,3-benzodioxol-5-yl)acetyl]-3-thiophenesulfonamide. Grades: Highly Purified. CAS No. 210421-74-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C18H14ClN2NaO6S2. US Biological Life Sciences.
Worldwide
Sitaxsentan sodium
Sitaxsentan sodium (IPI 1040 sodium; TBC11251 sodium) is an orally active, highly selective antagonist of endothelin A receptors. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IPI 1040 sodium; TBC11251 sodium. CAS No. 210421-74-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-11103.
site-1 protease
Cleaves sterol regulatory element-binding proteins (SREBPs) and thereby initiates a process by which the active fragments of the SREBPs translocate to the nucleus and activate genes controlling the synthesis and uptake of cholesterol and unsaturated fatty acids into the bloodstream. The enzyme also processes pro-brain-derived neurotrophic factor and undergoes autocatalytic activation in the endoplasmic reticulum through sequential cleavages. The enzyme can also process the unfolded protein response stress factor ATF6 at an Arg-His-Lys-Lys? site, and the envelope glycoprotein of the highly infectious Lassa virus and Crimean Congo hemorrhagic fever virus at Arg-Arg-Lys-Lys?. Belongs in... No. 167140-48-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4107; site-1 protease; EC 3.4.21.112; 167140-48-9; mammalian subtilisin/kexin isozyme 1; membrane-bound transcription factor site-1 protease; proprotein convertase SKI-1; proprotein convertase SKI-1/S1PPS1; S1P endopeptidase; S1P protease; site-1 peptidase; site-1 protease; SKI-1; SREBP proteinase; SREBP S1 protease; SREBP-1 proteinase; SREBP-2 proteinase; sterol regulatory element-binding protein proteinase; sterol regulatory element-binding protein site 1 protease; sterol-regulated luminal protease; subtilase SKI-1; subtilase SKI-1/S
This is a large group of enzymes, most of which form so-called 'restriction-modification systems' with nucleases that possess similar site specificity [the nucleases are listed as either EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease)]. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase. neb. com/rebase/rebase. html. Group: Enzymes. Synonyms: modification methylase; restriction-modification system. Enzyme Commission Number: EC 2.1.1.72. CAS No. 69553-52-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1974; site-specific DNA-methyltransferase (adenine-specific); EC 2.1.1.72; 69553-52-2; modification methylase; restriction-modification system. Cat No: EXWM-1974.
This is a large group of enzymes, most of which, with enzymes of similar site specificity listed as EC 3.1.21.3 (type 1 site-specific deoxyribonuclease), EC 3.1.21.4 (type II site-specific deoxyribonuclease) or EC 3.1.21.5 (type III site-specific deoxyribonuclease), form so-called 'restriction-modification systems'. A complete listing of all of these enzymes has been produced by R.J. Roberts and is available on-line at http://rebase. neb. com/rebase/rebase. html. Group: Enzymes. Synonyms: modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase. Enzyme Commission Number: EC 2.1.1.113. CAS No. 169592-50-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1712; site-specific DNA-methyltransferase (cytosine-N4-specific); EC 2.1.1.113; 169592-50-1; modification methylase; restriction-modification system; DNA[cytosine-N4]methyltransferase; m4C-forming MTase; S-adenosyl-L-methionine:DNA-cytosine 4-N-methyltransferase. Cat No: EXWM-1712.
Sitoindoside I
Sitoindoside I. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6-naphthalen-2-ylamino-1H-pyrimidine-2,4-dione. Appearance: Powder. CAS No. 18749-71-8. Molecular formula: C51H90O7. Mole weight: 815.3. Purity: 0.98. IUPACName: [(2R,3S,4S,5R,6R)-6-[[(3S,8S,9S,10R,13R,14S,17R)-17-[(2R,5R)-5-ethyl-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl]oxy]-3,4,5-trihydroxyoxan-2-yl]methyl hexadecanoate. Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCC1C(C(C(C(O1)OC2CCC3(C4CCC5(C(C4CC=C3C2)CCC5C(C)CCC(CC)C(C)C)C)C)O)O)O. Product ID: ACM18749718. Alfa Chemistry ISO 9001:2015 Certified.
Sitolactone
Sitolactone. Uses: Designed for use in research and industrial production. Product Category: Steroidal Compounds. CAS No. 126784-20-1. Molecular formula: C13H18O3. Mole weight: 222.28. Purity: 95%+. Product ID: ACM126784201. Alfa Chemistry ISO 9001:2015 Certified.
Sitostenone
Sitostenone is isolated from the roots of Xanthium sibiricum. Sitostenone has antioxidant activity and can be used in the treatment of androgen-dependent diseases, especially benign prostatic hyperplasia. Synonyms: Stigmast-4-en-3-one; (24R)-24-Ethylcholest-4-en-3-one; (24R)-Stigmast-4-en-3-one; 4-En-3-stigmastone; NSC 49082; β-Rosasterol oxide; β-Sitost-4-en-3-one; β-Sitostenone; Δ4-Sitosterol-3-one; beta-sitostenone. Grade: >98%. CAS No. 1058-61-3. Molecular formula: C29H48O. Mole weight: 412.69.
Sitravatinib (MGCD516) is an orally bioavailable receptor tyrosine kinase (RTK) inhibitor with IC 50 s of 1.5 nM, 2 nM, 2 nM, 5 nM, 6 nM, 6 nM, 8 nM, 0.5 nM, 29 nM, 5 nM, and 9 nM for Axl, MER, VEGFR3, VEGFR2, VEGFR1, KIT, FLT3, DDR2, DDR1, TRKA, TRKB, respectively [1]. Sitravatinib shows potent single-agent antitumor efficacy and enhances the activity of PD-1 blockade through promoting an antitumor immune microenvironment [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MGCD516; MG-516. CAS No. 1123837-84-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-16961.
SiTrzCz2
SiTrzCz2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-(6-(3-(Triphenylsilyl)phenyl)-1,3,5-triazine-2,4-diyl)bis(9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 2422045-58-5. Molecular formula: C51H35N5Si. Mole weight: 745.94 g/mol. Product ID: ACM2422045585. Alfa Chemistry ISO 9001:2015 Certified.
Sivelestat
Sivelestat (EI546) is a competitive inhibitor of human neutrophil elastase, with an IC50 of 44 nM and a Ki of 200 nM. Sivelestat (EI546) has the potential for the study of acute lung injury/acute respiratory distress syndrome or disseminated intravascular coagulation in COVID-19[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: EI546; LY544349; ONO5046. CAS No. 127373-66-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17443.
Sivelestat sodium
Sivelestat sodium. Uses: For analytical and research use. Group: Impurity standards. CAS No. 150374-95-1. Molecular formula: C20H21N2NaO7S. Mole weight: 456.45. Catalog: APB150374951.
Sivelestat sodium salt
Sivelestat sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 150374-95-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
SJ3149 is a selective and potent molecular glue degrader of CK1? protein with broad antiproliferative activity. SJ3149 can be used in cancer research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3026986-17-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-160444.
SJ6986
SJ6986 is a potent, selective and orally active GSPT1/2 Molecular Glue degrader, with a DC50 of 2.1 nM (Dmax 99%) for GSPT1[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2765625-93-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132199.
SJ6986
SJ6986 is a Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degrader from a Focused Library of Cereblon Modulator. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SJ6986; SJ-6986; SJ 6986. Product Category: Others. Appearance: Solid powder. CAS No. 2765625-93-0. Molecular formula: C20H14F3N3O7S. Mole weight: 497.4. Purity: >98%. IUPACName: N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O. Product ID: ACM2765625930. Alfa Chemistry ISO 9001:2015 Certified.
SJ988497
SJ988497 is a PROTAC JAK2 degrader. SJ988497 potently inhibits CRLF2-rearranged (CRLF2r) cell proliferation and degrades the CRBN neosubstrate GSPT1. SJ988497 consists of a Ruxolitinib (HY-50856) derivative, linker, and CRBN ligand Pomalidomide. SJ988497 can be used in the research of acute lymphoblastic leukemia (ALL)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2595365-41-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-151902.
SJF-0628
SJF-0628 (compound 512) is a PROTAC RAF degrader. SJF-0628 induces targeted degradation of BRAF mutants ( DC 50 : 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413035-41-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136420.
SJF-1521
SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230821-40-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131865.