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| Product | Description | |
|---|---|---|
| SiTrzCz2 | SiTrzCz2. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 9,9'-(6-(3-(Triphenylsilyl)phenyl)-1,3,5-triazine-2,4-diyl)bis(9H-carbazole). Product Category: Organic Light Emitting Diode (OLED). CAS No. 2422045-58-5. Molecular formula: C51H35N5Si. Mole weight: 745.94 g/mol. Product ID: ACM2422045585. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Sivelestat | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Synonyms: EI546; EI 546; EI-546; LY544349; LY 544349; LY-544349; ONO5046; ONO-5046; ONO 5046. Grades: >98%. CAS No. 127373-66-4. Molecular formula: C20H22N2O7S. Mole weight: 434.46. |  |
| Sivelestat sodium | Sivelestat sodium(ONO5046; LY544349; EI546) is a competitive inhibitor of human neutrophil elastase(IC50 = 44 nM; Ki=200 nM); also inhibited leukocyte elastase obtained from rabbit, rat, hamster and mouse. Synonyms: Sivelestat sodium. Grades: >98%. CAS No. 150374-95-1. Molecular formula: C20H21N2NaO7S. Mole weight: 456.44. | |
| Sivelestat sodium | Sivelestat sodium. Uses: For analytical and research use. Group: Impurity standards. CAS No. 150374-95-1. Molecular Formula: C20H21N2NaO7S. Mole Weight: 456.45. Catalog: APB150374951. |  |
| Sivelestat sodium salt | Sivelestat sodium salt. Group: Biochemicals. Grades: Purified. CAS No. 150374-95-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Sivelestat sodium tetrahydrate | Sivelestat is a competitive human neutrophil elastase (HNE) inhibitor (IC50 = 44 nM, Ki=0.2 μM). It also inhibits leukocyte elastase obtained from rabbit, rat, hamster and mouse (IC50 = 19 to 49 nM). However, it does not inhibit trypsin, thrombin, plasmin, plasma kallikrein, pancreas kallikrein, chymotrypsin and cathepsin G even at 100 μM. In in-vivo studies, it suppressed lung hemorrhage in hamster (ID50 = 82 μg/kg) by intratracheal administration and increase of skin capillary permeability in guinea pig (ID50 = 9.6 mg/kg) by intravenous administration, both of which were induced by human neutrophil elastase. Uses: Serine proteinase inhibitors. Synonyms: EI546 sodium tetrahydrate; EI 546 sodium tetrahydrate; EI-546 sodium tetrahydrate; LY544349 sodium tetrahydrate; LY 544349 sodium tetrahydrate; LY-544349 sodium tetrahydrate; ONO5046 sodium tetrahydrate; ONO 5046 sodium tetrahydrate; ONO-5046 sodium tetrahydrate. Grades: >98%. CAS No. 201677-61-4. Molecular formula: C20H29N2NaO11S. Mole weight: 528.51. | |
| Sivifene | Sivifene gel is the phenylhydrazone 4,4'-dihydroxybenzophenone-2,4-dinitrophenylhydrazone formulated as a topical agent with immunomodulating and potential antineoplastic activities. Applied topically as a gel, sivifene may stimulate a local immune response against human papillomavirus (HPV)-induced cervical intraepithelial neoplasia. Synonyms: A 007; A007; A-007; 4-[[2-(2,4-dinitrophenyl)hydrazinyl]-(4-hydroxyphenyl)methylidene]cyclohexa-2,5-dien-1-one; 4,4'-Dihydroxybenzophenone 2,4-dinitrophenylhydrazone. CAS No. 2675-35-6. Molecular formula: C19H14N4O6. Mole weight: 394.34. | |
| Sivifene | Sivifene (A-007) is a triaryl hydrazone. Sivifene has anticancer activity and immunomodulatory effects. Sivifene regulates immune regulation by upregulating CD45 T lymphocyte surface receptors [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: A-007. CAS No. 2675-35-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-14801. |  |
| Sivopixant | Sivopixant is a potent and selective P2X3 receptor antagonist. Sivopixant has the potential for the treatment of neuropathic pain and cough. Synonyms: S 600918; S-600918; S600918. CAS No. 2414285-40-6. Molecular formula: C25H22ClN5O5. Mole weight: 507.93. | |
| Siyry | A Kb-restricted epitope peptide. CAS No. 178561-37-0. Molecular formula: C50H71N11O13. Mole weight: 1034.1600000000001. | |
| SIYRY acetate | A Kb-restricted epitope peptide. Molecular formula: C52H75N11O15. Mole weight: 1094.25. | |
| SJ000291942 | SJ000291942 is a bone morphogenetic protein (BMP) signaling pathway activator. It activates BMP4 in C33A-2D2 human cervical cancer clone reporter cells (EC50 = ≤1 μM). Synonyms: CBMicro_010677; Oprea1_383864; SCHEMBL20620014; ZINC444226; BCP29880. Grades: 98%. CAS No. 425613-09-8. Molecular formula: C16H15FN2O4. Mole weight: 318.3. | |
| SJ 172550 | SJ 172550. Group: Biochemicals. Grades: Purified. CAS No. 431979-47-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SJ 172550 | SJ 172550 is a MDMX inhibitor (EC50 = 2.3 μM), controls the biological activity of MDMX. Uses: Mdmx inhibitor. Synonyms: MDMX Inhibitor II; SJ-172550; SJ 172550; SJ172550Methyl {2-chloro-6-ethoxy-4-[(E)-(3-methyl-5-oxo-1-phenyl-1,5-dihydro-4H-pyrazol-4-ylidene)methyl]phenoxy}acetate;2-[2-chloro-4-[(1,5-dihydro-3-methyl-5-oxo-1-phenyl-4H-pyrazol-4-ylidene)methyl]-6-ethoxyphenoxy]-acetic acid, methyl est. Grades: ≥98 %. CAS No. 431979-47-4. Molecular formula: C22H21ClN2O5. Mole weight: 428.9. | |
| SJ6986 | SJ6986 is a Potent, Selective, and Orally Bioavailable Small-Molecule GSPT1/2 Degrader from a Focused Library of Cereblon Modulator. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SJ6986; SJ-6986; SJ 6986. Product Category: Others. Appearance: Solid powder. CAS No. 2765625-93-0. Molecular formula: C20H14F3N3O7S. Mole weight: 497.4. Purity: >98%. IUPACName: N-(2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-5-yl)-2-(trifluoromethoxy)benzenesulfonamide. Canonical SMILES: O=S(C1=CC=CC=C1OC(F)(F)F)(NC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O. Product ID: ACM2765625930. Alfa Chemistry ISO 9001:2015 Certified. | |
| SJB2-043 | SJB2-043 is one of analogs/derivatives of C527, which is a novel and potent USP1 (ubiquitin-specific protease 1) inhibitor. It inhibited the Ub-VS labeling of a limited number of endogenous DUB enzymes and inhibited the labeling of USP1 with Ub-VS in a dose dependent manner. Synonyms: SJB2-043; SJB2043; SJB2 043. Grades: >98%. CAS No. 63388-44-3. Molecular formula: C17H9NO3. Mole weight: 275.26. | |
| SJF-0628 | SJF-0628 (compound 512) is a PROTAC RAF degrader. SJF-0628 induces targeted degradation of BRAF mutants ( DC 50 : 5.4 nM, 4.64 nM, 15.5 nM, 2.11 nM, 63.9 nM for BRAF V600E, V600K, G464V, G469A, K601E respectively). SJF-0628 has anti-tumor activity. SJF-0628 can be used for research of disorders that result from aggregation or accumulation of RAF, or the constitutive activation of RAF [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413035-41-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-136420. | |
| SJF-1521 | SJF-1521 is a selective EGFR PROTAC degrader. SJF-1521 contains the EGFR inhibitor lapatinib (HY-50898). SJF-1521 can induce EGFR degradation in OVCAR8 cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2230821-40-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-131865. | |
| SJG-136 | SJG-136 is a DNA cross-linking agent, with an XL50 of 45 nM for pBR322 DNA. SJG-136 has potent antitumor activity. Synonyms: SJG 136; SJG136; SJG-136; SP-2001; SP2001; SP 2001; BN 2629; BN2629; BN-2629; SG2000; SG 2000; SG-2000; NSC 694501; NSC694501; NSC-694501. Grades: >98.0%. CAS No. 232931-57-6. Molecular formula: C31H32N4O6. Mole weight: 556.61. | |
| SK1-IN-1 | SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor (IC50 = 58 nM). Synonyms: (2S,3S)-N-[(1S)-1-[4-[5-(2-cyclopentylethyl)-1,2,4-oxadiazol-3-yl]phenyl]ethyl]-3-hydroxypyrrolidine-2-carboxamide. CAS No. 1218816-71-7. Molecular formula: C22H30N4O3. Mole weight: 398.5. | |
| SK 216 | SK 216 is an orally available plasminogen activator inhibitor-1 (PAI-1) inhibitor. It inhibits VEGF-induced migration and tube formation in HUVECs, and suppresses angiogenesis in the tumor. SK 216 also attenuates TGF-β dependent epithelial-mesenchymal transition and fibroblast to myofibroblast differentiation in vitro. Synonyms: SK-216; SK 216; SK216.Plasminogen activator inhibitor-1 (PAI-1) inhibitor. 2-[5-[[6-[5-(1,1-Dimethylethyl)-2-benzoxazolyl]-2-naphthalenyl]oxy]pentyl]propanedioic acid disodium salt. Grades: ≥98% by HPLC. CAS No. 654080-03-2. Molecular formula: C29H29NO6Na2. Mole weight: 533.52. | |
| SK609 hydrochloride | SK609 hydrochloride is a dopamine D3 receptor (D3R) selective agonist with an EC 50 of 1109 nM. SK609 hydrochloride has the potential for parkinson research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1092797-77-7. Pack Sizes: 5 mg. Product ID: HY-117059. | |
| SKA-121 | SKA-121 is a positive-gating modulator of intermediate-conductance calcium-activated potassium channels (IKCa1/KCa3.1). It also activates KCa2.2 and KCa2.3 channels. In blood pressure telemetry experiments, SKA-121 (100 mg/kg i.p.) significantly lowered mean arterial blood pressure in normotensive and hypertensive wild-type but not in KCa3.1-/- mice. Synonyms: SKA121; SKA 121; 5-methylnaphtho[2,1-d]oxazol-2-amine. Grades: ≥98%. CAS No. 1820708-73-3. Molecular formula: C12H10N2O. Mole weight: 198.2. | |
| SKA 31 | SKA 31 is a KCa3.1 and KCa2 channel activator (EC50 = 260, 2900, 2900 nM for KCa3.1, KCa2.1 and KCa2.2, respectively). SKA 31b has been shown to potentiate acetylcholine-induced EDHF-type dilations of mouse carotid arteries and reduce blood pressure levels in normotensive and hypertensive mice. Synonyms: SKA-31; SKA 31; SKA31; Naphtho[1,2-d]thiazol-2-ylamine; 2-Amino-beta-naphthothiazole; 2-Aminonaphthiazole. Grades: ≥99% by HPLC. CAS No. 40172-65-4. Molecular formula: C11H8N2S. Mole weight: 200.26. | |
| SKA 31 | SKA 31. Group: Biochemicals. Grades: Purified. CAS No. 40172-65-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKA-31 | SKA-31 is a potent potassium channel activator with EC 50s of 260 nM, 1.9 μM, 2.9 μM, and 2.9 μM for KCa3.1 , KCa2.2 , KCa2.1 and KCa2.3 , respectively. SKA-31 potentiates endothelium-derived hyperpolarizing factor response and lowers blood pressure [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40172-65-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111655. | |
| Skatole | Skatole (3-methylindole) is a heterocyclic compound naturally found in the feces of vertebrates and can be found in certain plants. Skatole can be produced by intestinal bacteria, inducing apoptosis of intestinal epithelial cells through activating aryl hydrocarbon receptors ( AhR ) and p38. Skatole has been used in specific products of the perfume industry or as a flavor additive in ice cream [1] [2]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Methylindole; 3-Methyl-1H-indole. CAS No. 83-34-1. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W007355. | |
| Skeletal Nickel Catalyst slurry in Water | Skeletal Nickel Catalyst slurry in Water. Group: Biochemicals. Alternative Names: Raney Nickel slurry in Water. Grades: Highly Purified. CAS No. 7440-02-0. Pack Sizes: 25g, 50g, 100g, 250g, 500g. US Biological Life Sciences. | Worldwide |
| Skepinone-L | Skepinone-L is a selective p38α-MAPK inhibitor with IC50 of 5 nM. Grades: >98%. CAS No. 1221485-83-1. Molecular formula: C24H21F2NO4. Mole weight: 425.42. | |
| SKF 38393 hydrobromide | SKF 38393 hydrobromide is a selective dopamine D1-like receptor partial agonist (Ki = 1, ~ 0.5, ~ 150, ~ 5000 and ~ 1000 nM for D1, D5, D2, D3 and D4 receptors, respectively). Synonyms: SKF 38393 hydrobromide; SKF38393 hydrobromide; SKF-38393 hydrobromide; (±)-1-Phenyl-2,3,4,5-tetrahydro-(1H)-3-benzazepine-7,8-diol hydrobromide; 5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide. Grades: ≥99% by HPLC. CAS No. 20012-10-6. Molecular formula: C16H17NO2.HBr. Mole weight: 336.23. | |
| SKF 38393 hydrobromide | SKF 38393 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 20012-10-6. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| SKF-38393 hydrochloride | SKF-38393, aslo known as (+/-)-SKF-38393, is a synthetic compound of the benzazepine chemical class which acts as a selective D1/D5 receptor partial agonist. It has stimulant and anorectic effects. Synonyms: SKF-38393; SKF 38393; SKF38393; SKF-38,393; SKF 38,393; SKF38,393; SKF-38393 HCl; SKF-38393 hydrochloride. Grades: 98%. CAS No. 62717-42-4. Molecular formula: C16H18ClNO2. Mole weight: 291.78. | |
| SKF-525A, Hydrochloride (Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl) | Cytochrome P-459 inhibitor; blocks glibenclamide-sensitive K+ channels; inhibits neuronal nitric oxide synthetase; stimulates endothelial cell prostacyclin while inhibiting platelet thromboxane synthesis. Group: Biochemicals. Alternative Names: Proadifen, HCl, a-Phenyl-a-propylbenzeneacetic Acid 2-[Diethylamino]ethyl Ester, HCl. Grades: Highly Purified. Pack Sizes: 2g. US Biological Life Sciences. | Worldwide |
| SKF 77434 hydrobromide | SKF 77434 hydrobromide is a selective dopamine D1-like receptor partial agonist (IC50 = 19.7 and 2425 nM for binding to D1-like and D2-like receptors, respectively). Synonyms: SKF 77434 hydrobromide; SKF77434 hydrobromide; SKF-77434 hydrobromide; SKF-77434 HBr; SKF 77434 HBr; SKF77434 HBr; N-Allyl-SKF38393 HBr; 2,3,4,5-Tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide; N-Allyl-(+/-)-SKF-38393 hydrobromide. Grades: ≥99% by HPLC. CAS No. 300561-58-4. Molecular formula: C19H21NO2.HBr. Mole weight: 376.29. | |
| SKF 81297 | SKF 81297 is a potent and selective dopamine D1 receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 71636-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12236A. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide is a potent and selective dopamine D1 receptor agonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67287-39-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12236. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide is a selective dopamine D1-like receptor agonist. Synonyms: SKF 81297 hydrobromide; SKF81297 hydrobromide; SKF-81297 hydrobromide; (±)-6-Chloro-2,3,4,5-tetrahydro-1-phenyl-1H-3-benzazepine hydrobromide; 9-chloro-5-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol hydrobromide. Grades: ≥98% by HPLC. CAS No. 67287-39-2. Molecular formula: C16H16ClNO2.HBr. Mole weight: 370.67. | |
| SKF 81297 hydrobromide | SKF 81297 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-39-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF81367 | SKF81367, an impurity of Cefuroxime, is a cephalosporin antibiotic. Synonyms: SKF81367; SKF 81367; SKF-81367; (6R,7R)-3-(acetyloxymethyl)-7-[[(2Z)-2-(furan-2-yl)-2-methoxyiminoacetyl]amino]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid; Cefuracetime; Cefuracetima; Cefuracetimum. CAS No. 39685-31-9. Molecular formula: C17H17N3O8S. Mole weight: 423.4. | |
| SKF-82958 hydrobromide | SKF-82958 hydrobromide is a synthetic compound of the benzazepine class that acts as a D1/D5 receptor full agonist. It has characteristic anorectic effects, hyperactivity and self-administration in animals. It also acts as an agonist of ERα with negligible activity at ERβ, making it a subtype-selective estrogen. It could induce PPD, SP and PPE mRNA expression in the intact rat striatum. Uses: Skf-82958 hydrobromide has characteristic anorectic effects, hyperactivity and self-administration in animals. it also acts as an agonist of erα with negligible activity at erβ, making it a subtype-selective estrogen. Synonyms: (±)-SKF-82958 hydrobromide; SKF 82958 hydrobromide; SKF82958 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-1-phenyl-3-(2-propenyl)-1H-3-benzazepine-7,8-diol;Chloro-APB hydrobromide;(±)-6-Chloro-7,8-dihydroxy-3-allyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrobromide;6-Chloro-N-allyl-SKF-38393 hydrobromide. Grades: >98%. CAS No. 80751-65-1. Molecular formula: C19H21BrClNO2. Mole weight: 410.73. | |
| SKF 83566 hydrobromide | SKF 83566 hydrobromide is a potent and selective dopamine D1-like receptor antagonist (Ki~ 0.56 nM for D1; KB = 2 μM for D2). SKF 83566 is also reported to be an antagonist at the vascular 5-HT2 receptor (Ki = 11 nM). Uses: Adenylyl cyclase inhibitors. Synonyms: SKF 83566 hydrobromide; SKF83566 hydrobromide; SKF-83566 hydrobromide; 8-Bromo-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrobromide. Grades: ≥98% by HPLC. CAS No. 108179-91-5. Molecular formula: C17H18BrNO.HBr. Mole weight: 413.15. | |
| SKF 83822 hydrobromide | SKF 83822 hydrobromide is a selective and high affinity dopamine D1-like receptor agonist (Ki = 3.2, 3.1, 186, 66, 335, 1167, 1251 and 1385 nM at recombinant D1, D5, D2, D3, D4, 5-HT2A, α1A and α1B receptors, respectively). SKF 83822 stimulates adenylyl cyclase (EC50 = 65 nM) but not phosphoinositide hydrolysis. Synonyms: SKF 83822 hydrobromide; SKF83822 hydrobromide; SKF-83822 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-1-(3-methylphenyl)-3-(2-propenyl)-1H-3-benzazepine-7,8-diol hydrobromide; 9-chloro-5-(3-methylphenyl)-3-prop-2-enyl-1,2,4,5-tetrahydro-3-benzazepine-7,8-diol hydrobromide. Grades: ≥98% by HPLC. CAS No. 74115-10-9. Molecular formula: C20H22ClNO2.HBr. Mole weight: 424.76. | |
| SKF 83822 hydrobromide | SKF 83822 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 74115-10-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 83959 | SKF83959 is a potent and selective dopamine D 1 -like receptor partial agonist. SKF83959 K i values for rat D 1 , D 5 , D 2 and D 3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 can be used for the research of Alzheimer's disease and depression [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 80751-85-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-130344. | |
| SKF 83959 hydrobromide | SKF 83959 hydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 67287-95-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 83959 hydrobromide | SKF83959 hydrobromide is a potent and selective dopamine D 1 -like receptor partial agonist. SKF83959 hydrobromide K i values for rat D 1 , D 5 , D 2 and D 3 receptors are 1.18, 7.56, 920 and 399 nM, respectively. SKF83959 hydrobromide is a potent allosteric modulator of sigma (σ)-1 receptor. SKF83959 hydrobromide belongs to benzazepine family and has improvements on cognitive dysfunction. SKF83959 hydrobromide can be used for the research of Alzheimer's disease and depression [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67287-95-0. Pack Sizes: 5 mg. Product ID: HY-103412. | |
| SKF 83959 hydrobromide | SKF 83959 hydrobromide is a dopamine D1-like receptor partial agonist (Ki = 1.18, 7.56, 920 and 399 nM for rat D1, D5, D2 and D3 receptors, respectively), exhibiting anti-Parkinsonian effects and antagonizing the behavioral effects of cocaine. SKF 83959 also acts as an allosteric modulator of the σ1 receptor via potentiating binding of the σ1 receptor. Synonyms: SKF83959 hydrobromide; SKF-83959 hydrobromide; 6-Chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-1H-3-benzazepine-7,8-diol hydrobromide; 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, hydrobromide (1:1); 1H-3-Benzazepine-7,8-diol, 6-chloro-2,3,4,5-tetrahydro-3-methyl-1-(3-methylphenyl)-, monohydrobromide. Grades: ≥98% by HPLC. CAS No. 67287-95-0. Molecular formula: C18H20ClNO2.HBr. Mole weight: 398.73. | |
| SKF86002 | SKF86002 is a p38 MAP kinase inhibitor. SKF86002 inhibits IL-1 beta production by affecting at least two distinct steps in the biosynthesis of this cytokine. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKF-86002; SKF 86002; SKF86002. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 72873-74-6. Molecular formula: C16H12FN3S. Mole weight: 297.35. Purity: >98%. IUPACName: 6-(4-Fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole. Canonical SMILES: FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1. Product ID: ACM72873746. Alfa Chemistry ISO 9001:2015 Certified. | |
| SKF-86002 | SKF-86002 is a p38 MAP kinase inhibitor, the IC50 is 0.1 - 1 μM. It potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes, the IC50 is1 μM. It also acts as an inhibitor of both cyclooxygenase (COX) and 5-lipoxygenase (5-LO). In vitro: SKF-86002 inhibited prostaglandin H2 synthase activity, the IC50 is 120 mM as well as prostanoid production by rat basophilic leukemia cells, the IC50 is mM and its sonicate ( the IC50 is 100 mM and human monocytes (the IC50 is 1 mM. It inhibited the generation of dihydroxyeicosatetraenoic acid and 5-hydroxyeicosatetraenoic acid by a high speed supernatant fraction of RBL-1 cells (the IC50 is 10 mM). It blocked superoxide anion production in response to FMLP and reduced adhesion and chemotaxis in response to PAF or FMLP. Uses: Skf-86002 could potently inhibit lps-induced il-1 and tnf-α production in human monocytes. it acts as an inhibitor of both cyclooxygenase and 5-lipoxygenase. Synonyms: SKF-86002; SKF 86002; SKF86002. 6-(4-fluorophenyl)-5-(4-pyridyl)-2,3-dihydroimidazo[2,1-b]-thiazole; 4-(4-Pyridyl)-5-(4-fluorophenyl)-2,3-dihydro-1-thia-3a,6-diazapentalene. Grades: >98%. CAS No. 72873-74-6. Molecular formula: C16H12FN3S. Mole weight: 297.36. | |
| SKF 86002 dihydrochloride | SKF 86002 dihydrochloride is an inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 μM) with anti-inflammatory activity. SKF 86002 was indicated inhibition of LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 μM). It also inhibits 5-lipoxygenase- and cyclooxygenase-mediated arachidonic acid metabolism in RBL-1 cells (IC50 = 10 and 100 μM, respectively). Synonyms: SKF 86002 dihydrochloride; SKF86002 dihydrochloride; SKF-86002 dihydrochloride; 6-(4-Fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)imidazo[2,1-b]thiazole dihydrochloride. Grades: ≥98% by HPLC. CAS No. 116339-68-5. Molecular formula: C16H12FN3S.2HCl. Mole weight: 370.27. | |
| SKF 86002 dihydrochloride | SKF 86002 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 116339-68-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 86466 hydrochloride | SKF 86466 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 86129-54-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 86466 hydrochloride | SKF 86466 hydrochloride is a potent and selective α2 antagonist at pre- and post-junctional α2-adrenoceptors (Ki = 13 and 17 nM, respectively). SKF 86466 exhibits antihypertensive activity in a rat model. Uses: Adrenergic alpha-antagonists. Synonyms: SKF 86466 hydrochloride; SKF86466 hydrochloride; SKF-86466 hydrochloride; 6-Chloro-N-methyl-2,3,4,5-tetrahydro-1-H-3-benzazepine hydrochloride. Grades: ≥98% by HPLC. CAS No. 86129-54-6. Molecular formula: C11H14ClN.HCl. Mole weight: 232.15. | |
| SKF89976A | SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKF89976A; SKF 89976A; SKF-89976A. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 85375-15-1. Molecular formula: C22H25NO2. Mole weight: 335.45. Purity: >98%. IUPACName: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid. Canonical SMILES: O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O. Product ID: ACM85375151-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| SKF89976A HCl | SKF89976A is a potent GABA uptake inhibitor, which is selective for GAT-1 (IC50 values are 0.13, 550, 944 and 7210 μM for hGAT-1, rGAT-2, hGAT-3 and hBGT-1 respectively). SKF89976A inhibits transport current competitively (Ki = 7 μM) and transmitter-gated current non-competitively (Ki = 0.03 nM). It is able to pass the blood-brain barrier after systemic administration and is active in vivo. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKF89976A HCl; SKF 89976A; SKF-89976A; SKF89976A hydrochloride. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 85375-85-5. Molecular formula: C22H26ClNO2. Mole weight: 371.9. Purity: >98%. IUPACName: 1-(4,4-diphenylbut-3-en-1-yl)piperidine-3-carboxylic acid hydrochloride. Canonical SMILES: O=C(C1CN(CC/C=C(C2=CC=CC=C2)/C3=CC=CC=C3)CCC1)O.[H]Cl. Product ID: ACM85375855-1. Alfa Chemistry ISO 9001:2015 Certified. | |
| SKF 89976A hydrochloride | Cas No. 85375-15-1. | |
| SKF89976A hydrochloride | SKF89976A hydrochloride is a selective GABA transporter ( GAT-1 ) inhibitor with IC 50 s of 0.28 μM, 137.34 μM and 202.8 μM for GAT-1, GAT-2 and GAT-3 in CHO cells, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: d,l-SKF89976A hydrochloride. CAS No. 85375-15-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100228A. | |
| SKF 91488 dihydrochloride | SKF 91488 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 68941-21-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF 91488 dihydrochloride | SKF 91488 dihydrochloride is a potent inhibitor of histamine N-methyltransferase with no histamine agonist activity. SKF 91488 is used in the treatment of depression, anxiety and Parkinson's disease. Uses: The treatment of depression, anxiety and parkinson's disease. Synonyms: SKF 91488 dihydrochloride; SKF91488 dihydrochloride; SKF-91488 dihydrochloride; 4-(N,N-Dimethylamino)butylisothiourea dihydrochloride. CAS No. 68941-21-9. Molecular formula: C7H17N3S.2HCl. Mole weight: 248.21. | |
| SKF 91488 dihydrochloride | SKF 91488 (Homodimaprit) dihydrochloride is a potent and noncompetitive histamine N-methyltransferase inhibitor with a K i value of 0.9 microM. SKF 91488 dihydrochloride inhibits the methylation of labeled histamine in mice [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Homodimaprit dihydrochloride. CAS No. 68941-21-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100967. | |
| SKF-96365 | SKF-96365, a store-operated Ca2+ entry inhibitor, has been found to restrain the depolarization of circular smooth muscle caused by acetylcholine and also exhibit antineoplastic activity through leading to cells apoptosis. It has been already discontinued. Uses: Skf-96365 is a store-operated ca2+ entry inhibitor that has been found to restrain the depolarization of circular smooth muscle caused by acetylcholine and also exhibit antineoplastic activity through leading to cells apoptosis. Synonyms: SKF-96365; SKF 96365; SKF96365; 1-[2- (4-Methoxyphenyl) -2-[3- (4-methoxyphenyl) propoxy]ethyl]imidazole, 1-[-(3-(4-Methoxyphenyl)propoxy)-4-methoxyphenethyl]-1H-imidazole hydrochloride. Grades: 95%. CAS No. 130495-35-1. Molecular formula: C22H27ClN2O3. Mole weight: 402.91. | |
| SKF 96365 hydrochloride | SKF 96365 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 130495-35-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKF-96365 hydrochloride | SKF-96365 hydrochloride is a potent TRP channel blocker and a store-operated Ca 2+ entry (SOCE) inhibitor. SKF-96365 hydrochloride significantly inhibits hERG, hKCNQ1/hKCNE1, hKir2.1 and hKv4.3 current, and significantly prolongs the QTc interval in isolated guinea pig hearts. SKF-96365 hydrochloride exhibits potent anti-neoplastic activity by inducing cell-cycle arrest and apoptosis in colorectal cancer cells [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 130495-35-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100001. | |
| SKF-96365 hydrochloride | SKF-96365 hydrochloride is a non-selective TRP Channel blocker. |  |
| SKF 97541 | SKF 97541 is a highly potent GABAB agonist, and also acts as a GABAA-ρ antagonist. SKF 97541 exhibits sedative effects in mammals and has the potential to be used in the treatment of various addictions due to neurochemical imbalances. Uses: Potential treatment of addictions. Synonyms: SKF 97541; SKF97541; SKF-97541; 3-Aminopropyl(methyl)phosphinic acid; 3-Apmpa. CAS No. 127729-35-5. Molecular formula: C4H12NO2P. Mole weight: 137.12. | |
| SKF 97541 | SKF 97541. Group: Biochemicals. Grades: Purified. CAS No. 127729-35-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| SKI 178 | SKI 178 is a non-lipid sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM) used for the treatment of AML. SKI 178 has been shown to induce CDK1-dependent apoptosis in human acute myeloid leukemia cell lines. Uses: Aml treatment. Synonyms: SKI-178; SKI 178; SKI178. N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Grades: ≥98% by HPLC. CAS No. 1259484-97-3. Molecular formula: C21H22N4O4. Mole weight: 394.42. | |
| SKI-178 | SKI-178 is a sphingosine kinase 1 (SphK1) inhibitor (IC50 = 0.1-1.8 μM). SKI-178 induces prolonged mitosis followed by apoptotic cell death through the intrinsic apoptotic cascade. The sustained activation of CDK1 during prolonged mitosis, mediated by SKI-178 leads to the simultaneous phosphorylation of the prosurvival Bcl-2 family members, Bcl-2 and Bcl-xl, as well as the phosphorylation and subsequent degradation of Mcl-1. SKI-178 is a novel therapeutic agent for the treatment of AML, including multidrug-resistant/recurrent AML subtypes. Uses: Designed for use in research and industrial production. Additional or Alternative Names: SKI-178; SKI 178; SKI178. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 1259484-97-3. Molecular formula: C21H22N4O4. Mole weight: 394.43. Purity: >98%. IUPACName: N'-(1-(3,4-Dimethoxyphenyl)ethylidene)-3-(4-methoxyphenyl)-1H-pyrazole-5-carbohydrazide. Canonical SMILES: O=C(C1=CC(C2=CC=C(OC)C=C2)=NN1)N/N=C(C3=CC=C(OC)C(OC)=C3)\C. Product ID: ACM1259484973. Alfa Chemistry ISO 9001:2015 Certified. | |
| SKI-I | SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK) , with an IC 50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 ( IC 50 =11 μM). SKI-I induces apoptosis in tumor cell lines [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 306301-68-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115735. | |
| SKI II | 2-(p-Hydroxyanilino)-4-(p-chlorophenyl)thiazole (SK1-II) is a cell permeable, potent, and specific inhibitor of sphingosine kinase (IC50 = 0.5 μM). The compound does not bind to the ATP-binding site and does not affect the kinase activities of hERK2, hPI3K, or hPKCα at concentrations up to 60 μM. SK1-II showed anti-tumor properties, inducing apoptosis in a number of cell lines including those that express Pgp or MRP1 drug-transport proteins. Synonyms: SphK-I2; SKI-II; SKI II. Sphingosine kinase inhibitor II. Grades: >98%. CAS No. 312636-16-1. Molecular formula: C15H11ClN2OS. Mole weight: 302.78. | |
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