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| Product | Description | |
|---|---|---|
| acetate kinase | Requires Mg2+ for activity. While purified enzyme from Escherichia coli is specific for acetate, others have found that the enzyme can also use propanoate as a substrate, but more slowly. Acetate can be converted into the key metabolic intermediate acetyl-CoA by coupling acetate kinase with EC 2.3.1.8, phosphate acetyltransferase. Both this enzyme and EC 2.7.2.15, propionate kinase, play important roles in the production of propanoate. Group: Enzymes. Synonyms: acetokinase; AckA; AK; acetic kinase; acetate kinase (phosphorylating). Enzyme Commission Number: EC 2.7.2.1. CAS No. 9027-42-3. Acetate kinase. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3167; acetate kinase; EC 2.7.2.1; 9027-42-3; acetokinase; AckA; AK; acetic kinase; acetate kinase (phosphorylating). Cat No: EXWM-3167. |  |
| Acetate Kinase (Crude Enzyme) | In molecular biology, acetate kinase, which is predominantly found in micro-organisms, facilitates the production of acetyl-CoA byphosphorylating acetate in the presence of ATP and a divalent cation. The enzyme is important in the process of glycolysis, enzyme levels being increased in the presence of excess glucose. The growth of a bacterial mutant lacking acetate kinase has been shown to be inhibited by glucose, suggesting that the enzyme is involved in excretion of excess carbohydrate. This product with the indicated enzyme activity was briefly purified from engineered E. coli. Applications: Synthesis; industry. Group: Enzymes. Synonyms: acetokinase; AckA; AK; acetic kinase; acetate kinase (phosphorylating). Enzyme Commission Number: EC 2.7.2.1. CAS No. 9027-42-3. Acetate kinase. Activity: Undetermined. Appearance: Clear to translucent yellow solution. Storage: at -20 °C or lower, for at least 1 month. Source: E. coli. acetokinase; AckA; AK; acetic kinase; acetate kinase (phosphorylating). Pack: 100ml. Cat No: NATE-1826. | |
| acetate kinase (diphosphate) | This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a carboxy group as acceptor. The systematic name of this enzyme class is diphosphate:acetate phosphotransferase. This enzyme is also called pyrophosphate-acetate phosphotransferase. This enzyme participates in pyruvate metabolism. Group: Enzymes. Synonyms: pyrophosphate-acetate phosphotransferase. Enzyme Commission Number: EC 2.7.2.12. CAS No. 57657-58-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3170; acetate kinase (diphosphate); EC 2.7.2.12; 57657-58-6; pyrophosphate-acetate phosphotransferase. Cat No: EXWM-3170. | |
| Native Bacillus stearothermophilus Acetate Kinase | In molecular biology, acetate kinase (EC 2.7.2.1), which is predominantly found in micro-organisms, facilitates the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation. Short-chain fatty acids (SCFAs) play a major role in carbon cycle and can be utilized as a source of carbon and energy by bacteria. The enzyme is important in the process of glycolysis, enzyme levels being increased in the presence of excess glucose. The growth of a bacterial mutant lacking acetate kinase has been shown to be inhibited by glucose, suggesting that the enzyme is involved in excretion of excess carbohydRate. A related enzyme, butyRate kinase, ... acetate kinase from creative enzymes. this [32p]-acetyl phosphate was used to label bldm, bldm d-54n or bldm d-54a loci during the study of the effect of bldm gene on streptomyces coelicolor development. Group: Enzymes. Synonyms: Acetate kinase (phosphorylating); Acetic kinase; Acetokinase; EC 2.7.2.1; 9027-42-3; Acetate kinase. Enzyme Commission Number: EC 2.7.2.1. CAS No. 9027-42-3. Acetate kinase. Activity: 400-1,200 units/mg solid. Storage: 2-8°C. Form: lyophilized powder. Contains potassium phosphate buffer. Source: Bacillus stearothermophilus. Acetate kinase (phosphorylating); Acetic kinase; Acetokinase; EC 2.7.2.1; 9027-42-3; Acetate kinase. Cat No: NATE-0016. | |
| Native Escherichia coli Acetate Kinase | In molecular biology, acetate kinase (EC 2.7.2.1), which is predominantly found in micro-organisms, facilitates the production of acetyl-CoA by phosphorylating acetate in the presence of ATP and a divalent cation. Short-chain fatty acids (SCFAs) play a major role in carbon cycle and can be utilized as a source of carbon and energy by bacteria. The enzyme is important in the process of glycolysis, enzyme levels being increased in the presence of excess glucose. The growth of a bacterial mutant lacking acetate kinase has been shown to be inhibited by glucose, suggesting that the enzyme is involved in excretion of excess carbohydRate. A related enzyme, butyRate kinase, facili...rom escherichia coli has been used as part of an atp-regenerating system to study the kinetics of agonist-stimulated transphosphatidylatio. Group: Enzymes. Synonyms: Acetate kinase (phosphorylating); Acetic kinase; Acetokinase; AK; EC 2.7.2.1; 9027-42-3; Acetate kinase. Enzyme Commission Number: EC 2.7.2.1. CAS No. 9027-42-3. Acetate kinase. Activity: > 150 units/mg protein (biuret). Storage: -20°C. Form: Lyophilized powder containing trehalose with small amounts of potassium phosphate, magnesium chloride, and dithiothreitol. Source: Escherichia coli. Acetate kinase (phosphorylating); Acetic kinase; Acetokinase; AK; EC 2.7.2.1; 9027-42-3; Acetate kinase. Cat No: NATE-0017. | |
| Nur77 LBD Antagonist, TMPA (AMPK Signaling Activator XII, Liver Kinase B Activator, LKB1 Activator, MARK Signaling Activator, STK11 Activator, TR3 LBD Antagonist, Ethyl-2- (2, 3, 4-trimethoxy-6- (1-octanoyl) phenyl) acetate) | A cell-permeable phenylacetate compound that blocks Nur77 (TR3) LKB1 nuclear-sequestering function by antagonizing against Nur77-LKB1 interaction via direct binding at the LKB1 LBD/ligand binding domain (Kd = 0.14 against 5uM LKB1 binding to 5uM full-length Nur77). Shown to induce LKB1 Ser428 phosphorylation (10 & 20uM for 6h) and LKB1 nuclear-to-cytosol translocation in hepatic LO2 cells, resulting in enhanced phosphorylations of LKB1 cytosolic effectors AMPKalpha and MARK1/2/3 without affecting Nur77 transactivation activity. Daily i.p. dosing (50mg/kg) is shown to increase liver LKB1 Ser428/AMPKalpha Thr172 phosphorylations in diabetic db/db mice in vivo, effectively improving animal glucose tolerance. Also reported to lower fasting blood glucose level in STZ-treated, high fat diet-fed type II diabetic mice. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Protein Kinase C 19-31 acetate | Protein Kinase C 19-31 acetate is a peptide inhibitor of protein kinase C (PKC) originating in the pseudo-substrate regulatory domain of PKCA (residues 19-31). It is used as a protein kinase C substrate peptide for testing the protein kinase C activity. Synonyms: PKC (19-31) acetate; H-Arg-Phe-Ala-Arg-Lys-Gly-Ala-Leu-Arg-Gln-Lys-Asn-Val-OH.CH3CO2H; L-arginyl-L-phenylalanyl-L-alanyl-L-arginyl-L-lysyl-glycyl-L-alanyl-L-leucyl-L-arginyl-L-glutaminyl-L-lysyl-L-asparagyl-L-valine acetic acid. Grades: ≥95%. Molecular formula: C69H122N26O18. Mole weight: 1603.90. |  |
| Protein Kinase C Peptide Substrate acetate | Protein Kinase C Peptide Substrate acetate targets specific cell compartments and activates G protein-coupled receptors, tyrosine kinase receptors, or tyrosine kinase-coupled receptors by relying on second messenger and specific adaptor proteins in response to extracellular signals. It regulates a variety of physiological functions, including nervous, endocrine, exocrine, inflammatory, and immune system activation. Synonyms: L-α-Glutamyl-L-arginyl-L-methionyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-arginyl-L-glutaminylglycyl-L-seryl-L-valyl-L-arginyl-L-arginyl-L-arginyl-L-valine acetate; H-Glu-Arg-Met-Arg-Pro-Arg-Lys-Arg-Gln-Gly-Ser-Val-Arg-Arg-Arg-Val-OH acetate. Grades: ≥95%. Molecular formula: C85H159N39O23S. Mole weight: 2127.52. | |
| 1,4-Diaminoanthraquinone | An anthraquinone derivative that is a potent and selective protein kinase CK1 delta inhibitor. Studies suggest that it has potential solar cell applications. Used in studies as a potential competitive non-peptidic inhibitor of HIV-1 proteinase. Group: Biochemicals. Alternative Names: 1,4-Diamino-9,10-anthraquinone; Acetate Red Violet R; Acetoquinone Light Heliotrope NL; Acetylon Fast Red Violet R; Akasperse Violet 3R; Amacel Heliotrope R; Cibacet Violet 2R; C.I. 61100; NSC 63807; NSC 7833; Krisolamine; Violet 14447. Grades: Highly Purified. CAS No. 128-95-0. Pack Sizes: 2.5g. US Biological Life Sciences. | Worldwide |
| 2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosylamine | 2,3,4,6-Tetra-O-acetyl-β-D-galactopyranosylamine is useful to the preparation of organo-selenium glycosides and disaccharides which target multiple kinases and are capable of inhibiting cancer progression to metastases. Synonyms: β-D-Galactopyranosylamine 2,3,4,6-Tetraacetate. Grades: 95%. CAS No. 58484-22-3. Molecular formula: C14H21NO9. Mole weight: 347.32. | |
| 2,3,4-Tri-O-acetyl-6-methyl- β-D-glucopyranuronosyl Genistein Glucuronide Methyl Ester Triacetate | 2,3,4-Tri-O-acetyl-6-methyl- β-D-glucopyranuronosyl Genistein Glucuronide Methyl Ester Triacetate is the protected metabolite of Genistein (G350000) which exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C41H42O23. US Biological Life Sciences. | Worldwide |
| 5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester | 5-Amino-2-chlorobenzotrifluoride N-Chloroacetyl N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50 = 83 nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R, 3R, 4S, 5S, 6S)-2- ( (4-Chloro-3- (trifluoromethyl)phenyl) (chlorocarbonyl)amino)-6- (methoxycarbonyl)tetrahydro-2H-pyran-3, 4, 5-triyl Triacetate. Molecular formula: C21H20Cl2F3NO10. Mole weight: 574.29. | |
| 5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester | 5-Amino-2-chlorobenzotrifluoride N-Dehydroxy-2,3,4-tri-O-acetyl-D-glucuronic Acid Methyl Ester is an intermediate in the synthesis of Regorafenib N-β-D-Glucuronide Sodium Salt, which is a derivative of Regorafenib and a compound that inhibits PDGFR tyrosine kinase with IC50=83nM. Also useful for the treatment of inflammation and as an anti-proliferative agent. Synonyms: (2R,3R,4S,5S,6S)-2-((4-Chloro-3-(trifluoromethyl)phenyl)amino)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C20H21ClF3NO9. Mole weight: 511.83. | |
| Abl Cytosolic Substrate acetate | Abl Cytosolic Substrate acetate is a substrate for Abelson tyrosine kinase (Abl). Synonyms: Glu-Ala-Ile-Tyr-Ala-Ala-Pro-Phe-Ala-Lys-Lys-Lys acetate salt; L-α-Glutamyl-L-alanyl-L-isoleucyl-L-tyrosyl-L-alanyl-L-alanyl-L-prolyl-L-phenylalanyl-L-alanyl-L-lysyl-L-lysyl-L-Lysine acetate salt. Grades: ≥95%. CAS No. 2918768-10-0. Molecular formula: C64H101N15O16.C2H4O2. Mole weight: 1396.63. | |
| AMARA peptide acetate | AMARA peptide acetate is a substrate for salt-induced kinase (SIK) and adenosine monophosphate-activated protein kinase (AMPK). Molecular formula: C64H119N27O19S. Mole weight: 1602.89. | |
| Anisomycin (Flagecidin, Antibiotic SA 3097C1, Antibiotic PA 106, Anhydroscopin A, NSC) | Anisomycin is a phenyl methyl enepyrrolidine first isolated from Streptomyces griseolus in 1954 as an antiprotozoan with antifungal activity. Anisomycin acts as an inhibitor of protein synthesis by binding to the 60S ribosomal subunit. Interestingly, anisomycin has found use for the induction of amnesia in animal models. More recently, anisomycin has been demonstrated to induce apoptosis, to be a selective signalling agonist, to activate mitogen-activated protein (MAP) kinases and to be immunomodulatory via its action on T cells. Group: Biochemicals. Alternative Names: ((2R,3S,4S)-2-(4-Methoxybenzyl)-3,4-pyrrolidinediol-3-acetate, 2-[(4-Methoxyphenyl)methyl]-3,4-pyrrolidinediol 3-acetate. Grades: Highly Purified. CAS No. 22862-76-6. Pack Sizes: 25mg, 100mg, 250mg. US Biological Life Sciences. | Worldwide |
| Autocamtide-2-related inhibitory peptide, myristoylated acetate | Autocamtide-2-related inhibitory peptide, myristoylated acetate is a CaM kinase II inhibitor that blocks the reinstatement of morphine-seeking behavior in vivo by pretreatment. It is an enhanced cell-permeable derivative of autocamtide-2-related inhibitory peptide. Synonyms: AIP Myristoylated acetate; Myr-AIP acetate; N2-(1-Oxotetradecyl)-L-lysyl-L-lysyl-L-alanyl-L-leucyl-L-arginyl-L-arginyl-L-glutaminyl-L-α-glutamyl-L-alanyl-L-valyl-L-α-aspartyl-L-alanyl-L-leucine acetate; m-AIP acetate; Myristoylated autocamtide-2-related inhibitory peptide acetate; H-Lys(myristoyl)-Lys-Ala-Leu-Arg-Arg-Gln-Glu-Ala-Val-Asp-Ala-Leu-OH.CH3CO2H. Grades: ≥95%. Molecular formula: C80H146N22O22. Mole weight: 1768.15. | |
| β-Galactosyl-C18-ceramide Tetraacetate | β-Galactosyl-C18-ceramide Tetraacetate is an intermediate formed in the β-Galactosyl-C18-ceramide synthesis, which is a galactosylceramides involved in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. They have shown to have important immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma. Synonyms: (2R,3S,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3R,E)-3-hydroxy-2-stearamidooctadec-4-en-1-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C50H89NO12. Mole weight: 896.24. | |
| Calcineurin substrate acetate | Calcineurin substrate acetate is a peptide from the regulatory RII subunit of cAMP-dependent protein kinase. Synonyms: H-Asp-Leu-Asp-Val-Pro-Ile-Pro-Gly-Arg-Phe-Asp-Arg-Arg-Val-Ser-Val-Ala-Ala-Glu-OH.CH3CO2H; L-α-Aspartyl-L-leucyl-L-α-aspartyl-L-valyl-L-prolyl-L-isoleucyl-L-prolylglycyl-L-arginyl-L-phenylalanyl-L-α-aspartyl-L-arginyl-L-arginyl-L-valyl-L-seryl-L-valyl-L-alanyl-L-alanyl-L-glutamic acid acetate. Grades: ≥95%. Molecular formula: C94H154N28O31. Mole weight: 2172.40. | |
| CDK2 acetate | CDK2 acetate, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Synonyms: H-His-His-Ala-Ser-Pro-Arg-Lys-OH.CH3CO2H; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C37H61N15O11. Mole weight: 891.99. | |
| Dehydroanonaine | Dehydroanonaine is a dietary supplement that is used for the treatment of pain. It inhibits the activity of creatine kinase, which is an enzyme that breaks down adenosine triphosphate (ATP) to produce energy. Dehydroanonaine also inhibits acetate extract from fatty acids and has been shown to have an inhibitory effect on tyrosinase, an enzyme involved in the production of melanin. The effective dose for dehydroanonaine is not known. Dehydroanonaine can be used cosmetically by increasing the skin's elasticity and reducing wrinkles and age spots. Group: Other alkaloids. CAS No. 41679-82-7. Molecular formula: C17H13NO2. Mole weight: 263.29 g/mol. Canonical SMILES: C1CNC2= CC3= CC= CC= C3C4= C2C1= CC5= C4OCO5. Catalog: ACM41679827. |  |
| Destearaldehyde β-Galactosyl-C18-ceramide Tetraacetate | Destearaldehyde β-Galactosyl-C18-ceramide Tetraacetate is an intermediate formed in the synthesis of β-Galactosyl-C18-ceramide, which is a galactosylceramide that promote the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. They have shown to have critical immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma. Synonyms: (2R,3S,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3R,E)-2-amino-3-hydroxyoctadec-4-en-1-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C32H55NO11. Mole weight: 629.78. | |
| Destearaldehyde-N-tert-butyloxycarbonyl β-Galactosyl-C18-ceramide Tetraacetate | Destearaldehyde-N-tert-butyloxycarbonyl β-Galactosyl-C18-ceramide Tetraacetate is an intermediate formed in the synthesis of β-Galactosyl-C18-ceramide, which is a galactosylceramide that plays an important role in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. They have shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma. Synonyms: (2R,3S,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3R,E)-2-((tert-butoxycarbonyl)amino)-3-hydroxyoctadec-4-en-1-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C37H63NO1313. Mole weight: 729.9. | |
| Destearaldehyde-O-tert-butyldimethylsilyl-N-tert-butyloxycarbonyl β-Galactosyl-C18-ceramide Tetraacetate | Destearaldehyde-O-tert-butyldimethylsilyl-N-tert-butyloxycarbonyl β-Galactosyl-C18-ceramide Tetraacetate is an intermediate formed in the synthesis of β-Galactosyl-C18-ceramide, which is a galactosylceramide that plays an important role in promoting the regulation of nerve cells, regulating protein kinase C activities and modulating the function of the hormone receptor. They have shown to have significant immunostimulatory and anti-umor activity in mice with liver metastasis of the Colon26 adenocarcinoma. Synonyms: (2R,3S,4S,5R,6R)-2-(Acetoxymethyl)-6-(((2S,3R,E)-2-((tert-butoxycarbonyl)amino)-3-((tert-butyldimethylsilyl)oxy)octadec-4-en-1-yl)oxy)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C43H77NO13Si. Mole weight: 844.16. | |
| Dimethyl dicarbonate | Dimethyl dicarbonate (DMDC) is an organic compound which is a Colorless liquid with a sharp odor at room temperature. It is primarily used as a beverage preservative, processing aid, or sterilant (INS No. 242), and acts by inhibiting the enzymes acetate kinase and L-glutamic acid decarboxylase. It has also been proposed that DMDC inhibits the enzymes alcohol dehydrogenase and glyceraldehyde 3-phosphate dehydrogenase by causing the methoxycarbonylation of their histidine components. Group: Heterocyclic organic compound. Alternative Names: methoxycarbonyl methyl carbonate;DMPC Dimethyl pyrocarbonate Pyrocarbonic acid dimethyl ester. CAS No. 4525-33-1. Molecular formula: C4H6O5. Mole weight: 134.09. IUPACName: methoxycarbonyl methyl carbonate. Canonical SMILES: COC(=O)OC(=O)OC. Density: 1.242 g/cm³. Catalog: ACM4525331. | |
| Epidermal Growth Factor Receptor Peptide acetate | Epidermal Growth Factor Receptor Peptide exists on the cell surface and is activated by the binding of its specific ligands. EGFR belongs to the tyrosine kinase receptor (RTK) ErbB family. Synonyms: H-Asp-Val-Val-Asp-Ala-Asp-Glu-Tyr-Leu-Ile-Pro-Gln-OH.CH3CO2H; L-alpha-aspartyl-L-valyl-L-valyl-L-alpha-aspartyl-L-alanyl-L-alpha-aspartyl-L-alpha-glutamyl-L-tyrosyl-L-leucyl-L-isoleucyl-L-prolyl-L-glutamine acetic acid; EGF Receptor (985-996) (human) acetate. Grades: ≥95%. Molecular formula: C63H97N13O25. Mole weight: 1436.52. | |
| Hexadecyl acetyl glycerol | Hexadecyl acetyl glycerol (HAG) is an inhibitor of protein kinase C (PKC). It also inhibits the growth and induces differentiation of HL-60 cells. Synonyms: HAG; 1-O-Hexadecyl-2-acetyl-sn-glycerol; 1-Palmityl-2-acetylglycerol; (S)-1-(Hexadecyloxy)-3-hydroxypropan-2-yl acetate. Grades: ≥90%. CAS No. 77133-35-8. Molecular formula: C21H42O4. Mole weight: 358.6. | |
| JIP-1 (153-163) acetate | JIP-1 (153-163) acetate is a c-Jun N-terminal kinase (JNK) peptide inhibitor based on JNK-interacting protein-1 (JIP-1) residues 153-163. It binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK. Synonyms: L-Phenylalaninamide, L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparaginyl-L-leucyl-, acetate (1:1); H-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH2.CH3CO2H; L-arginyl-L-prolyl-L-lysyl-L-arginyl-L-prolyl-L-threonyl-L-threonyl-L-leucyl-L-asparagyl-L-leucyl-L-phenylalaninamide acetate salt. Grades: ≥95%. CAS No. 1417623-78-9. Molecular formula: C61H104N20O14.C2H4O2. Mole weight: 1401.66. | |
| KYL acetate | KYL is a selective and potent EphA4 receptor tyrosine kinase antagonist with a Kd value of 0.8 μM. It inhibits EphA4-EphrinA5 interactions with an IC50 value of 6.34 μM. It prevents AβO induced dendritic spine loss and synaptic damage. It also prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. It shows a long half-life in cell culture media. It has a neuroprotective effect. Synonyms: L-Leucine, L-lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-, acetate; L-Lysyl-L-tyrosyl-L-leucyl-L-prolyl-L-tyrosyl-L-tryptophyl-L-prolyl-L-valyl-L-leucyl-L-seryl-L-seryl-L-leucine acetate; KYL peptide acetate; Lys-Tyr-Leu-Pro-Tyr-Trp-Pro-Val-Leu-Ser-Ser-Leu acetate salt. Grades: ≥95%. Molecular formula: C74H108N14O17.C2H4O2. Mole weight: 1525.78. | |
| Lyn peptide inhibitor acetate | Lyn peptide inhibitor acetate is a potent and cell-permeable inhibitor of the Lyn-coupled IL-5 receptor signaling pathway, while keeping other signals intact. It blocks Lyn activation and inhibits the binding of Lyn tyrosine kinase to the βc subunit of IL-3/GM-CSF/IL-5 receptors. It can be used for the study of asthma, allergic, and other eosinophilic disorders. Synonyms: stearoyl-Tyr-Gly-Tyr-Arg-Leu-Arg-Arg-Lys-Trp-Glu-Glu-Lys-Ile-Pro-Asn-Pro-NH2.CH3CO2H; N-stearoyl-L-tyrosyl-glycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-alpha-glutamyl-L-alpha-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparagyl-L-prolinamide acetic acid; N-(1-Oxooctadecyl)-L-tyrosylglycyl-L-tyrosyl-L-arginyl-L-leucyl-L-arginyl-L-arginyl-L-lysyl-L-tryptophyl-L-α-glutamyl-L-α-glutamyl-L-lysyl-L-isoleucyl-L-prolyl-L-asparaginyl-L-prolinamide acetate. Grades: ≥95%. CAS No. 2918771-52-3. Molecular formula: C117H188N30O26. Mole weight: 2430.98. | |
| Malantide acetate | Malantide acetate, a highly specific substrate for PKA, is a synthetic dodecapeptide derived from the site phosphorylated by cAMP-dependent protein kinase (PKA) on the β-subunit of phosphorylase kinase. Synonyms: H-Arg-Thr-Lys-Arg-Ser-Gly-Ser-Val-Tyr-Glu-Pro-Leu-Lys-Ile-OH.CH3CO2H; L-arginyl-L-threonyl-L-lysyl-L-arginyl-L-seryl-glycyl-L-seryl-L-valyl-L-tyrosyl-L-alpha-glutamyl-L-prolyl-L-leucyl-L-lysyl-L-isoleucine acetic acid. Grades: ≥95%. Molecular formula: C74H128N22O23. Mole weight: 1693.97. | |
| MLCK inhibitor peptide 18 acetate | MLCK inhibitor peptide 18 acetate is a selective competitive myosin light chain kinase (MLCK) inhibitor (IC50 = 50 nM) that inhibits CaM kinase II only at 4000-fold higher concentrations. Synonyms: H-Arg-Lys-Lys-Tyr-Lys-Tyr-Arg-Arg-Lys-NH2.CH3CO2H; L-arginyl-L-lysyl-L-lysyl-L-tyrosyl-L-lysyl-L-tyrosyl-L-arginyl-L-arginyl-L-lysinamide acetate. Grades: ≥95%. Molecular formula: C62H109N23O13. Mole weight: 1384.67. | |
| NADH kinase | CTP, ITP, UTP and GTP can also act as phosphate donors (in decreasing order of activity). The enzyme is specific for NADH. Activated by acetate. Group: Enzymes. Synonyms: reduced nicotinamide adenine dinucleotide kinase (phosphorylating); DPNH kinase; reduced diphosphopyridine nucleotide kinase; NADH2 kinase. Enzyme Commission Number: EC 2.7.1.86. CAS No. 62213-39-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3116; NADH kinase; EC 2.7.1.86; 62213-39-2; reduced nicotinamide adenine dinucleotide kinase (phosphorylating); DPNH kinase; reduced diphosphopyridine nucleotide kinase; NADH2 kinase. Cat No: EXWM-3116. | |
| Native Porcine Creatine Kinase | Creatine Kinase is an enzyme present in muscle, brain, and other tissues of vertebrates that catalyzes the reversible conversion of ADP and phosphocreatine into ATP and creatine. Elevated levels of creatine phosphokinase indicates possible Brain injury or stroke, convulsions, delirium tremens, Dermatomyositis or polymyositis, electric shock, Heart attack, Inflammation of the heart muscle (myocarditis), Lung tissue death (pulmonary infarction), Muscular dystrophies and Myopathy. Group: Enzymes. Synonyms: EC 2.7.3.2; ATP:creatine phosphotransferase; CK; CPK; creatine phosphokinase; creatine phosphotransferase; phosphocreatine kinase; adenosine triphosphate-creatine transphosphorylase; 9001-15-4. Enzyme Commission Number: EC 2.7.3.2. CAS No. 9001-15-4. Activity: > 300 U/mg. Appearance: Reddish to pink lyophilized powder. Storage: Store at -20° C. Form: Lyophilized from tris acetate, DTT and EDTA, pH: 7.0. Source: Porcine Heart. Species: Porcine. EC 2.7.3.2; ATP:creatine phosphotransferase; CK; CPK; creatine phosphokinase; creatine phosphotransferase; phosphocreatine kinase; adenosine triphosphate-creatine transphosphorylase; 9001-15-4. Cat No: NATE-1884. | |
| Nimbolide | Nimbolide is a triterpene derived from the leaves and flowers of neem (Azadirachta indica). Nimbolide induces apoptosis through inactivation of NF-κB. Nimbolide inhibits CDK4/CDK6 kinase activity. Nimbolide suppresses the NF-κB, Wnt, PI3K-Akt, MAPK and JAK-STAT signaling pathways. Group: Inhibitors. CAS No. 25990-37-8. Molecular formula: C27H30O7. Mole weight: 466.52. Appearance: Powder. Purity: 0.98. IUPACName: methyl 2-[6-(furan-3-yl)-7, 9, 11, 15-tetramethyl-12, 16-dioxo-3, 17-dioxapentacyclo[9.6.1.02, 9.04, 8.015, 18]octadeca-7, 13-dien-10-yl]acetate. Canonical SMILES: CC1=C2C (CC1C3=COC=C3)OC4C2 (C (C5 (C6C4OC (=O)C6 (C=CC5=O)C)C)CC (=O)OC)C. Catalog: ACM25990378. | |
| pep2-AVKI acetate | pep2-AVKI acetate is a selective peptide inhibitor that selectively disrupts the binding of the AMPA receptor subunit GluA2 (at the C-terminal PDZ site) to protein interacting with C kinase (PICK1). Synonyms: L-Tyrosyl-L-asparaginyl-L-valyl-L-tyrosylglycyl-L-isoleucyl-L-α-glutamyl-L-alanyl-L-valyl-L-lysyl-L-isoleucine acetate salt; H-Tyr-Asn-Val-Tyr-Gly-Ile-Glu-Ala-Val-Lys-Ile-OH.CH3CO2H; L-Isoleucine, L-tyrosyl-L-asparaginyl-L-valyl-L-tyrosylglycyl-L-isoleucyl-L-α-glutamyl-L-alanyl-L-valyl-L-lysyl-, acetate salt. Grades: ≥95%. Molecular formula: C62H97N13O19. Mole weight: 1328.51. | |
| Phorbol 12-myristate 13-acetate | Phorbol 12-myristate 13-acetate (PMA), a phorbol ester, is a dual SphK and protein kinase C (PKC) activator [1] [2]. Phorbol 12-myristate 13-acetate is a NF-κB activator. Phorbol 12-myristate 13-acetate induces differentiation in THP-1 cells [3] [7]. Uses: Scientific research. Group: Natural products. Alternative Names: PMA; TPA; Phorbol myristate acetate. CAS No. 16561-29-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18739. |  |
| Phorbol 12-myristate 13-acetate (PMA, TPA, 12-O-Tetradecanoylphorbol 13-acetate) | Most commonly-used phorbol ester. Binds to and activates protein kinase C (PKC) at nM concentrations. Induces cell growth arrest through a variety of pathways including the mitogen-activated protein kinases (MAPKs), p38 and c-Jun N-terminal kinase (JNK) pathways mediated by cyclin dependent kinase (CDK) inhibitors such as p21WAF1/CIP1, p27KIP1, p15 and p16. Potent mouse skin tumor promoter. Promoter of inducible NOS (iNOS; NOS II). Apoptosis inducer. Potential effective cancer therapeutic agent. Inhibitor of anti-lipolytic activity of insulin. Group: Biochemicals. Alternative Names: PMA; TPA; 12-O-Tetradecanoylphorbol 13-acetate. Grades: Highly Purified. CAS No. 16561-29-8. Pack Sizes: 1mg, 5mg, 10mg. Molecular Formula: C36H56O8, Molecular Weight: 616.83. US Biological Life Sciences. | Worldwide |
| Pitavastatin Impurity 20 | Pitavastatin Impurity 20 is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Uses: A hmg-coa reductase inhibitor intermediate. Synonyms: (4R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic Acid tert-Butyl Ester; tert-butyl syn-(3R,5S)-6-chloro-3,5-(isopropylidenedioxy)-hexanoate; (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid; t-butyl (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxan-4-ylacetate; (4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic Acid 1,1-Dimethylethyl Ester. Grades: 96%. CAS No. 154026-94-5. Molecular formula: C13H23ClO4. Mole weight: 278.77. | |
| PKA inhibitor fragment (6-22) amide acetate | PKA Inhibitor Fragment (6-22) amide acetate is a synthetic peptide inhibitor of cAMP-dependent protein kinase (PKA) (Ki = 2.5 nM), derived from the heat-stable PKA inhibitor protein PKI. It is the shortest synthetic PKI peptide that retains high potency for PKA inhibition. Synonyms: H-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-NH2.CH3CO2H; L-threonyl-L-tyrosyl-L-alanyl-L-alpha-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-seryl-glycyl-L-arginyl-L-threonyl-glycyl-L-arginyl-L-arginyl-L-asparagyl-L-alanyl-L-isoleucinamide acetic acid. Grades: ≥95%. Molecular formula: C82H134N28O26. Mole weight: 1928.11. | |
| PKC ζ pseudosubstrate acetate | PKC ζ pseudosubstrate acetate, a synthetic peptide, is an inhibitor of protein kinase C (PKC) ζ that is attached to cell permeabilization Antennapedia domain vector peptide. It consists of amino acids 113-129 PKC ζ pseudosubstrate domains connected by a disulfide bridge to the cell permeabilization Antennapedia domain vector peptide. Synonyms: Protein kinase C zeta pseudosubstrate acetate; L-cysteinyl-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginyl-glycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucyl-L-tyrosyl-L-arginyl-L-alanyl-L-asparagine (1->1')-disulfide compound with L-cysteinyl-L-arginyl-L-glutaminyl-L-isoleucyl-L-lysyl-L-isoleucyl-L-tryptophyl-L-phenylalanyl-L-glutaminyl-L-asparagyl-L-arginyl-L-arginyl-L-methionyl-L-lysyl-L-tryptophyl-L-lysyl-L-lysine; H-Cys-Ser-Ile-Tyr-Arg-Arg-Gly-Ala-Arg-Arg-Trp-Arg-Lys-Leu-Tyr-Arg-Ala-Asn-OH.H-Cys-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH (Disulfide bridge: Cys1-Cys1'). Grades: ≥95%. Molecular formula: C210H340N74O46S3. Mole weight: 4733.68. | |
| PKG Substrate acetate | PKG Substrate acetate is a selective substrate for cGMP-dependent protein kinase (PKG). Synonyms: H-Arg-Lys-Arg-Ser-Arg-Ala-Glu-OH.CH3CO2H; L-arginyl-L-lysyl-L-arginyl-L-seryl-L-arginyl-L-alanyl-L-glutamic acid acetic acid. Grades: ≥95%. Molecular formula: C37H71N17O13. Mole weight: 962.08. | |
| PKI (5-24) acetate | PKI (5-24) acetate is a competitive, non-reversible peptide inhibitor of PKA (cAMP-dependent protein kinase) (Ki = 2.3 nM). Synonyms: H-Thr-Thr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile-His-Asp-OH.CH3CO2H; L-Threonyl-L-threonyl-L-tyrosyl-L-alanyl-L-α-aspartyl-L-phenylalanyl-L-isoleucyl-L-alanyl-L-serylglycyl-L-arginyl-L-threonylglycyl-L-arginyl-L-arginyl-L-asparaginyl-L-alanyl-L-isoleucyl-L-histidyl-L-aspartic acid acetate salt; PKI(5-24) acetate salt. Grades: ≥95%. Molecular formula: C96H152N32O33. Mole weight: 2282.43. | |
| PMA | PMA, extracted from seeds of Euphorbia lathyris L, is a phorbol ester that is commonly used to activate certain types of protein kinase C (PKC), including group A (α, βI, βII, γ) and group B (δ, ε, η, θ) isoforms. It has been shown to inhibit apoptosis induced by the Fas antigen, but PMA induces apoptosis in HL-60 promyelocytic leukemia cells. Synonyms: Phorbol-12-Myristate-13-Acetate; 12-O-Tetradecanoylphorbol 13-acetate, 4β, 9α, 12β, 13α, 20-Pentahydroxytiglia-1, 6-dien-3-one 12-tetradecanoate; 12 Myristoyl 13 acetylphorbol; 12 O Tetradecanoyl Phorbol 13 Acetate; 12-Myristoyl-13-acetylphorbol; 12-O-Tetradecanoyl Phorbol 13-Acetate; 13-Acetate, 12-O-Tetradecanoyl Phorbol; Acetate, Phorbol Myristate; Acetate, Tetradecanoylphorbol; Myristate Acetate, Phorbol; Phorbol 13-Acetate, 12-O-Tetradecanoyl; Phorbol Myristate Acetate; Tetradecanoylphorbol Acetate; Tetradecanoylphorbol Acetate, 4a alpha Isomer; Tetradecanoylphorbol Acetate, 4a alpha-Isomer. Grades: ≥95%. CAS No. 16561-29-8. Molecular formula: C36H56O8. Mole weight: 616.83. | |
| propionate kinase | Requires Mg2+. Acetate can also act as a substrate. Involved in the anaerobic degradation of L-threonine in bacteria. Both this enzyme and EC 2.7.2.1, acetate kinase, play important roles in the production of propanoate. Group: Enzymes. Synonyms: PduW; TdcD; propionate/acetate kinase. Enzyme Commission Number: EC 2.7.2.15. CAS No. 39369-28-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3173; propionate kinase; EC 2.7.2.15; 39369-28-3; PduW; TdcD; propionate/acetate kinase. Cat No: EXWM-3173. | |
| Sakamototide substrate peptide acetate | Sakamototide substrate peptide acetate is a substrate peptide of a member of the kinase AMPK family and is used for the determination of kinase activity. Synonyms: H-Ala-Leu-Asn-Arg-Thr-Ser-Ser-Asp-Ser-Ala-Leu-His-Arg-Arg-Arg-OH.CH3CO2H; L-alanyl-L-leucyl-L-asparagyl-L-arginyl-L-threonyl-L-seryl-L-seryl-L-alpha-aspartyl-L-seryl-L-alanyl-L-leucyl-L-histidyl-L-arginyl-L-arginyl-L-arginine acetic acid. Grades: ≥95%. CAS No. 2703746-19-2. Molecular formula: C71H126N30O25. Mole weight: 1799.97. | |
| ST638 | ST638 is a tyrosine kinase inhibitor and PLD inhibitor. It suppresses tyrosine phosphorylation induced by tumor necrosis factor-α and phorbol myristate acetate in neutrophils and by angiotensin II in cardiac fibroblasts. Uses: Enzyme inhibitors. Synonyms: (Z)-2-cyano-3-[3-ethoxy-4-hydroxy-5-(phenylsulfanylmethyl)phenyl]prop-2-enamide. Grades: ≥98%. CAS No. 107761-24-0. Molecular formula: C19H18N2O3S. Mole weight: 354.4. | |
| STO-609 acetate | STO-609 acetate is a selective and cell-permeable inhibitor of Ca2+-calmodulin-dependent protein kinase kinase (CaMKK) (Ki = 80 and 15 ng/ml for inhibition of CaM-KKα and CaM-KKβ, respectively). It displays > 80-fold selectivity over CaMK1, CaMK2, CaMK4, MLCK, PKC, PKA and p42 MAPK. STO-609 can be used as a tool for evaluating the physiological significance of the CaM-KK-mediated pathway in vivo and in vitro. Synonyms: STO-609 acetate; STO 609 acetate; STO609 acetate; 7-Oxo-7H-benzimidazo[2,1-a]benz[de]isoquinoline-3-carboxylic acid acetate. Grades: ≥98% by HPLC. CAS No. 1173022-21-3. Molecular formula: C19H10N2O3.C2H4O2. Mole weight: 374.35. | |
| Syntide 2 acetate | Syntide-2 acetate, a synthetic peptide, is recognized as a substrate by Ca2+/calmodulin-dependent protein kinase II (CaMKII) (Ki = 12 μM) and protein kinase C (Km = 11 μM). Synonyms: H-Pro-Leu-Ala-Arg-Thr-Leu-Ser-Val-Ala-Gly-Leu-Pro-Gly-Lys-Lys-OH.CH3CO2H; L-prolyl-L-leucyl-L-alanyl-L-arginyl-L-threonyl-L-leucyl-L-seryl-L-valyl-L-alanyl-glycyl-L-leucyl-L-prolyl-glycyl-L-lysyl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C70H126N20O20. Mole weight: 1567.85. | |
| Tetromycin A | An unusual tetronic acid, structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. It is an antibiotic produced by Streptomyces. It has pronounced activity against antibiotic susceptible and resistant gram-positive bacteria including MRSA. It appears to target the phosphatidylinositide-3-kinase/akt signalling pathway. Synonyms: [1S-(1R*, 4R*, 4aR*, 6aS*, 7E, 11E, 12aS*, 15S*, 16aR*, 20aR*, 20bS*)]-4-(acetyloxy)-2, 3, 4, 4a, 6a, 9, 10, 12a, 15, 16, 20a, 20b-dodecahydro-21-hydroxy-1, 6, 7, 11, 12a, 14, 15, 20a-octamethyl-18H-16a, 19-Metheno-16aH-benzo[b]naphth[2, 1-j]oxacyclotetradecin-18, 20(1H)-dione; 8-Demethyl-17,32-dideoxy-12,20-dimethyl-kijanolide 9-Acetate. Grades: >99% by HPLC. CAS No. 180027-83-2. Molecular formula: C36H48O6. Mole weight: 576.76. | |
| Wortmannin | It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. Uses: Immunosuppressive agents. Synonyms: Antibiotic SL-2052; (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione; (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. Grades: 98%. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43. | |
| ZIP acetate | ZIP acetate is a cell-permeable inhibitor of protein kinase Mζ (PKMζ), which is a constitutively active and atypical PKC isozyme involved in LTP maintenance. ZIP selectively blocks PKMζ-induced synaptic potentiation in hippocampal slices in vitro. ZIP reverses late-phase LTP (IC50 = 1-2.5 μM) and produces persistent loss of 1-day-old spatial memory following central administration in vivo. Synonyms: myristoyl-Arg-Leu-Tyr-Arg-Lys-Arg-Ile-Trp-Arg-Ser-Ala-Gly-Arg-OH.CH3CO2H; N-myristoyl-L-arginyl-L-leucyl-L-tyrosyl-L-arginyl-L-lysyl-L-arginyl-L-isoleucyl-L-tryptophyl-L-arginyl-L-seryl-L-alanyl-glycyl-L-arginine acetic acid; N-(1-Oxotetradecyl)-L-seryl-L-isoleucyl-L-tyrosyl-L-arginyl-L-arginylglycyl-L-alanyl-L-arginyl-L-arginyl-L-tryptophyl-L-arginyl-L-lysyl-L-leucine acetate; Peptide ZIP acetate; z-Pseudosubstrate inhibitory peptide acetate. Grades: ≥94%. Molecular formula: C92H158N30O19. Mole weight: 1988.43. | |
| 1,1-Dimethoxy-N,N-dimethylmethanamine | 1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes. Group: Biochemicals. Alternative Names: 1,1-Dimethoxy-trimethylamine; (Dimethoxymethyl) dimethylamine; (Dimethylamino) dimethoxymethane; (Dimethylamino) formaldehyde Dimethyl Acetal; 1,1-Dimethoxy-N,N-dimethylmethanamine; 1, 1-Dimethoxytri methyl amine; DMF Dimethyl Acetal; DMFDMA; Dimethoxy (dimethylamino) methane; Dimethoxy-N,N-dimethylmethanamine; Dimethoxy-N,N-dimethylmethylamine; Dimethyl Dimethylformamide Acetal; Dimethylformamide Dimethyl Acetal; Methyl-8; N, N-Dimethyl-1, 1-bis (methyloxy) methanamine; N,N-Dimethylformamide Dimethyl Acetal; N-(Dimethoxymethyl)-N,N-dimethylamine; N- (Dimethoxymethyl) dimethylamine; α , α -Dimethoxytri methyl amine. Grades: Highly Purified. CAS No. 4637-24-5. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 1,2-bis(4-methylpiperazin-1-yl)ethanone | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Piperazine, 1-methyl-4-[(4-methyl-1-piperazinyl)acetyl]-(5CI); Nintedanib Impurity E. Grades: ≥95%. CAS No. 856843-88-4. Molecular formula: C12H24N4O. Mole weight: 240.35. | |
| 1-(6-((6-acetyl-8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidin-2-yl)amino)-1-oxidopyridin-3-yl)piperazine 1-oxide | An impurity of Palbociclib which is a selective inhibitor of the cyclin-dependent kinases CDK4 and CDK6. Synonyms: Palbociclib Impurity 25. Grades: >95%. CAS No. 2488840-59-9. Molecular formula: C24H29N7O4. Mole weight: 479.54. | |
| 1-Acetamido-4-cyano-3-methylisoquinoline (1-Acetamido-3-methyl-4-cyanosoquinoline) | A selective inhibitor of cyclic AMP-dependent protein kinase (PKA). Group: Biochemicals. Alternative Names: 1-Acetamido-3-methyl-4-cyanosoquinoline. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| 1-Oleoyl-2-acetyl-sn-glycerol | 1-Oleoyl-2-acetyl-sn-glycerol is a cell-permeable analog of the PKC-activating second messenger DAG. It activates PKC in platelets, resulting in the phosphorylation of a 40 kDa protein. Activator of phospholipid-dependent protein kinase C and stimulator of secretion and aggregation in blood platelets. Synonyms: 18:1-2:0 DG; 1-(9Z-octadecenoyl)-2-acetoyl-sn-glycerol; DG(18:1(9Z)/2:0/0:0); OAG; 2-Acetyl-1-oleoyl-sn-glycerol; 1-O-Octadecenoyl-2-O-acetylglycerol. Grades: ≥90%. CAS No. 86390-77-4. Molecular formula: C23H42O5. Mole weight: 398.58. | |
| 1-Oleoyl-2-acetyl-sn-glycerol | 1-Oleoyl-2-acetyl-sn glycerol is a synthetic, cell permeable diacylglycerol analog. 1-Oleoyl-2-acetyl-sn glycerol activates calcium-dependent protein kinase C (PKC) and induces the superoxide-production. Uses: Scientific research. Group: Signaling pathways. CAS No. 86390-77-4. Pack Sizes: 5 mg (25.09 mM * 500 μL in Acetonitrile); 10 mg (25.09 mM * 1 mL in Acetonitrile); 25 mg (25.09 mM * 2.5 mL in Acetonitrile). Product ID: HY-131648. | |
| 1-Oleoyl-2-acetyl-sn-glycerol (OAG) | Activator of phospholipid-dependent protein kinase C; and stimulator of secretion and aggregation in blood platelets. Group: Biochemicals. Alternative Names: OAG. Grades: Highly Purified. CAS No. 86390-77-4. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| 2-((1-Acetyl-3-iodo-1H-indazol-6-yl)thio)-N-methylbenzamide | An impurity of Axitinib, a tyrosine kinase inhibitor used for the treatment of kidney cancer. Synonyms: Benzamide, 2-[(1-acetyl-3-iodo-1H-indazol-6-yl)thio]-N-methyl-; Axitinib impurity YXA. Grades: ≥95%. CAS No. 1639138-00-3. Molecular formula: C17H14IN3O2S. Mole weight: 451.28. | |
| 2,2'-(piperazine-1,4-diyl)bis(N-methyl-N-(4-nitrophenyl)acetamide) | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: Nintedanib Impurity G. Grades: ≥95%. CAS No. 2410649-54-4. Molecular formula: C22H26N6O6. Mole weight: 470.48. | |
| 2,3,4-Tri-O-acetyl- β-D-glucuronic Acid Methyl Ester Propan-2-ol-D6 | 2,3,4-Tri-O-acetyl- β-D-glucuronic Acid Methyl Ester Propan-2-ol-D6 is an intermediate in the synthesis of Propylene Glycol-d6 1-Glucuronide (Mixture of Diastereomers) Sodium Salt (P835237). Isotope labelled Propylene Glycol 1-Glucuronide is a metabolite of propylene glycol, used in the synthesis of N-terminal kinase inhibitors with cellular activity. Acts as a solvent for various pharmaceutical compounds. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C16H18D6O11. US Biological Life Sciences. | Worldwide |
| 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid | 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid reduces the secretion of IL-1 β, TNF-α and IL-10 from purified murine macrophages but not of T cells; and reduces the activation of NF-κB and p38 MAP kinase pathways along with up-regulation of ERK pathways. 2-(3-Phenyl-4,5-dihydroisoxazol-5-yl)acetic Acid inhibits proliferation of enterobacterial antigen-reactive CD4+CD25- T cells in vitro. Group: Biochemicals. Grades: Highly Purified. CAS No. 6501-72-0. Pack Sizes: 5mg, 10mg. Molecular Formula: C11H11NO3, Molecular Weight: 205.21. US Biological Life Sciences. | Worldwide |
| 2',4'-Dichloro-2-imidazole Acetophenone | Intermediate in the preparation of glycogen synthase kinase-3 (GSK-3). Group: Biochemicals. Alternative Names: 1-(2,4-Dichlorophenyl)-2-(1H-imidazol-2-yl)ethanone. Grades: Highly Purified. CAS No. 252950-14-4. Pack Sizes: 100mg. US Biological Life Sciences. | Worldwide |
| (2,4-Difluorophenoxy)acetic Acid Methyl Ester | (2,4-Difluorophenoxy)acetic Acid Methyl Ester is an intermediate in the synthesis of Pamapimod (P167500), a selective inhibitor of the α-isoform of p38 MAP kinase. Group: Biochemicals. Grades: Highly Purified. CAS No. 449811-63-6. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H8F2O3. US Biological Life Sciences. | Worldwide |
| 2-(4-methylpiperazin-1-yl)-N-(4-nitrophenyl)acetamide | An impurity of Nintedanib, a receptor tyrosine kinase (RTK) inhibitor that binds to vascular endothelial growth factor receptor, fibroblast growth factor receptor and platelet derived growth factor receptor. Nintedanib is used as a medication for the treatment of idiopathic pulmonary fibrosis. Synonyms: 4-Methyl-N-(4-nitrophenyl)-1-piperazineacetamide; Nintedanib Impurity F. Grades: ≥95%. CAS No. 708279-23-6. Molecular formula: C13H18N4O3. Mole weight: 278.31. | |
| 2-((4R,6S)-6-((E)-2-(2-Cyclopropyl-4-phenylquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester | 2-((4R,6S)-6-((E)-2-(2-Cyclopropyl-4-phenylquinolin-3-yl)vinyl)-2,2-dimethyl-1,3-dioxan-4-yl)acetic Acid tert-Butyl Ester is one of pitavastatin impurities. Pitavastatin, also called as itavastatin, is a potent HMG-CoA reductase inhibitor. And studies showed that pitavastatin inhibited the activity of Rho-kinase depending on the inactivation of Rho by inhibiting the mevalonate pathway. Molecular formula: C32H37NO4. Mole weight: 499.64. | |
| 2-Acetamido-5-chloroisonicotinic Acid | 2-Acetamido-5-chloroisonicotinic Acid is a chemical reagent used in the synthesis of p38a protein kinase inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 944390-08-3. Pack Sizes: 1g, 5g. Molecular Formula: C8H7ClN2O3, Molecular Weight: 214.61. US Biological Life Sciences. | Worldwide |
| 2-Acetyl-6-methylphenol | 2-Acetyl-6-methylphenol is used to prepare (hydroxyphenyl) (piperidinyl)pyridines as IκB kinase β inhibitors and orally active anti-inflammatory agents. Group: Biochemicals. Grades: Highly Purified. CAS No. 699-91-2. Pack Sizes: 100mg, 250mg. Molecular Formula: C9H10O2, Molecular Weight: 150.169999999999. US Biological Life Sciences. | Worldwide |
| 2-Acetylamino-4-methylpyridine | 2-Acetylamino-4-methylpyridine is a chemical reagent used in the synthesis of potent inhibitors of Eimeria tenalla cGMP-dependant protein kinase as antiparasitic agents. Also used in the 1-pot synthesis of difluoromethyl-2-pyridone derivatives. Group: Biochemicals. Grades: Highly Purified. CAS No. 5327-32-2. Pack Sizes: 5g, 25g. Molecular Formula: C8H10N2O, Molecular Weight: 150.18. US Biological Life Sciences. | Worldwide |
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