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1-(4'-Acetyl[1,1'-biphenyl]-4-yl)-2-bromo-ethanone is an intermediate/impurity towards Daclatasvir (D101500), an inhibitor of the HCV protein NS5A that may be used as a drug candidate for the treatment of hepatitis C (HCV). Group: Biochemicals. Grades: Highly Purified. CAS No. 36934-45-9. Pack Sizes: 500mg, 1g. Molecular Formula: C16H13BrO2, Molecular Weight: 317.18. US Biological Life Sciences.
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1-(4'-Acetyl(1,1'-biphenyl)-4-yl)ethanone
1-(4'-Acetyl(1,1'-biphenyl)-4-yl)ethanone. Group: Biochemicals. Alternative Names: 4,4'-Diacetylbiphenyl. Grades: Highly Purified. CAS No. 787-69-9. Pack Sizes: 50g, 100g, 250g, 500g, 1Kg. Molecular Formula: C16H14O2. US Biological Life Sciences.
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2-(4-Acetyl-2-fluoro-biphenyl-4yl)propionate
A intermediate in the synthesis for the metabolite of Flurbiprofen, an anti-inflammatory used as an analgesic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
An intermediate for the synthesis of the metabolite of Flurbiprofen, an anti-inflammatory used as an analgesic. Group: Biochemicals. Alternative Names: 4'-Acetyl-2-fluoro-α-methyl-d3-[1,1'-biphenyl]-4-acetic Acid Methyl Ester;Methyl 2-(4-Acetyl-2-fluoro-biphenyl-4-yl)propionate-d3. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
ethyl 4-acetyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate is an impurity of Olmesartan Medoxomil. Olmesartan Medoxomil is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. It is a metabolite of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. hAT1 receptors: IC50 = 6.18 nM. Synonyms: Ethyl 4-acetyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate; Ethyl4-acetyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate. CAS No. 2101308-74-9. Molecular formula: C44H40N6O3. Mole weight: 700.84.
ethyl 5-acetyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4-carboxylate is an impurity of Olmesartan Medoxomil. Olmesartan Medoxomil is an angiotensin II receptor antagonist which has been used for the treatment of high blood pressure. It is a metabolite of Olmesartan, which is a specific angiotensin II type 1 (AT1) receptor antagonist with antihypertensive effect. hAT1 receptors: IC50 = 6.18 nM. Synonyms: Ethyl 5-acetyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4-carboxylate; Ethyl5-acetyl-2-propyl-1-((2'-(1-trityl-1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-imidazole-4-carboxylate. CAS No. 2101308-73-8. Molecular formula: C44H40N6O3. Mole weight: 700.84.
methyl ((S)-1-((S)-2-(5-(4'-(5-((S)-1-acetylpyrrolidin-2-yl)-1H-pyrrol-2-yl)-[1,1'-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidin-1-yl)-3-methyl-1-oxobutan-2-yl)carbamate. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C36H42N6O4. Mole Weight: 622.77. Catalog: APB10260.
N-Acetyl-4-aminobiphenyl
N-Acetyl-4-aminobiphenyl is a metabolite of 4-Aminobiphenyl, a procarcinogenic agent. Group: Biochemicals. Alternative Names: N-[1,1'-Biphenyl]-4-ylacetamide; 4-(Acetylamino)biphenyl; 4-Acetamidobiphenyl; 4'-Phenylacetanilide; NSC 227192; NSC 3134; NSC 65931; p-Phenylacetanilide. Grades: Highly Purified. CAS No. 4075-79-0. Pack Sizes: 100mg. US Biological Life Sciences.
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N-Acetyl-4-aminobiphenyl-d5
Labeled N-Acetyl-4-aminobiphenyl. N-Acetyl-4-aminobiphenyl is a metabolite of 4-Aminobiphenyl, a procarcinogenic agent. Group: Biochemicals. Alternative Names: N-[1,1'-Biphenyl-d5]-4-ylacetamide; 4-(Acetylamino)biphenyl-d5; 4-Acetamidobiphenyl-d5; 4'-Phenylacetanilide-d5; NSC 227192-d5; NSC 3134-d5; NSC 65931-d5; p-Phenylacetanilide-d5. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
A butyl diazaspirononenone derivative used in the preparation of acetylcholinesterase inhibitors. An impurity found in Irbesartan. Group: Biochemicals. Alternative Names: 2-Butyl-3-[[2'-(cyano)biphenyl-4-yl]methyl]-1,3-diazaspiro[4.4]non-1-en-4-one. Grades: Highly Purified. CAS No. 138401-24-8. Pack Sizes: 2.5g. US Biological Life Sciences.
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Altenusin
Altenusin is a a biphenyl derivative with an IC50 value of 4.3±0.3 μM in the TR assay, which is isolated from the endophytic fungus Alternaria. It inhibits Src kinase with an IC50 value of 20 nM. Altenusin inhibits fibrillization of recombinant tau fragments in vitro and phosphorylation of tau in SH-SY5Y cells expressing human P301L mutant tau when used at a concentration of 10 μM. Altenusin is known to have antioxidant properties and to inhibit several enzymes, including myosin light chain kinase, sphingomyelinase, acetylcholinesterase, cFMS kinase, pp60c-SRc kinase and HIV-1 integrase. Synonyms: Alutenusin; MS 341; MS-341; MS341. Grades: ≥98%. CAS No. 31186-12-6. Molecular formula: C15H14O6. Mole weight: 290.27.
AVE-0118
AVE 0118 is a potassium channel blocker that has the potential for the treatment of sleep apnea syndrome. AVE 0118 functions without apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefore contribute to the anti-AF property of AVE0118. Synonyms: [1,1'-Biphenyl]-2-carboxamide, 2'-[[[2-(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-; 2'-[[[2-(4-Methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl][1,1'-biphenyl]-2-carboxamide; [1,1'-Biphenyl]-2-carboxamide, 2'-[[[(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-; 2'-[[2- (4-Methoxyphenyl) acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide; AVE 0118; AVE0118. Grades: ≥95%. CAS No. 498577-53-0. Molecular formula: C30H29N3O3. Mole weight: 479.57.
AVE 0118 hydrochloride
AVE 0118 hydrochloride is a potassium channel blocker that has the potential for the treatment of sleep apnea syndrome. AVE 0118 functions without apparent effect on ventricular repolarization. Noteworthy, the atrial selective and dose-dependent prolongation of atrial refractoriness (ERP) by AVE 0118 has been claimed to be an inhibitory effect of sodium channel activity in an atrial-selective manner, and may therefore contribute to anti-AF property of AVE0118. Synonyms: Benzeneacetamide, 4-methoxy-N-[[2'-[[[2-(3-pyridinyl)ethyl]amino]carbonyl][1,1'-biphenyl]-2-yl]methyl]-, hydrochloride (1:1); 2'-[[[2-(4-Methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl][1,1'-biphenyl]-2-carboxamide hydrochloride; [1,1'-Biphenyl]-2-carboxamide, 2'-[[[(4-methoxyphenyl)acetyl]amino]methyl]-N-[2-(3-pyridinyl)ethyl]-, hydrochloride; 2'-[[2- (4-Methoxyphenyl) acetylamino]methyl]biphenyl-2-carboxylic acid (2-pyridin-3-yl-ethyl)amide hydrochloride; AVE 0118 hydrochloride; AVE0118 hydrochloride. Grades: 99%. CAS No. 2108821-80-1. Molecular formula: C30H29N3O3.HCl. Mole weight: 516.03.
Candesartan N-Trityl O-Tri-acetyl Acyl-glucuronide Methyl Ester is an intermediate in synthesizing Candesartan Acyl-Glucuronide, a metabolite of Candesartan, an angiotensin II type-1 receptor antagonist. Used in treatment of congestive heart failure. Antihypertensive. Synonyms: (2S,3R,4S,5S,6S)-2-((2-Ethoxy-1-((2'-(2-trityl-2H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-1H-benzo[d]imidazole-7-carbonyl)oxy)-6-(methoxycarbonyl)tetrahydro-2H-pyran-3,4,5-triyl Triacetate. Molecular formula: C56H50N6O12. Mole weight: 999.03.
Erastin2
Erastin2 is a ferroptosis inducer and an inhibitor of the system xc- cystine/glutamate transporter, which inhibits glutamate release in CCF-STTG1 cells with an IC50 of 0.0035 μM. Synonyms: 2-[[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]methyl]-3-[4-(1-methylethoxy)[1,1'-biphenyl]-3-yl]-4(3H)-quinazolinone. Grades: ≥98%. CAS No. 1695533-44-8. Molecular formula: C36H35ClN4O4. Mole weight: 623.14.
Flurbiprofen Axetil
An anti-inflammatory used as an analgesic. Group: Biochemicals. Alternative Names: 2-Fluoro-α-methyl-[1,1'-biphenyl]-4-acetic Acid 1-(Acetyloxy)ethyl Ester; 1-Acetoxyethyl 2-(2-Fluoro-4-biphenylyl)propionate; LFP 83; Ropiopn. Grades: Highly Purified. CAS No. 91503-79-6. Pack Sizes: 100mg. US Biological Life Sciences.
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Flurbiprofen Axetil (Mixture of Diastereomers)
Flurbiprofen Axetil (Mixture of Diastereomers) is an anti-inflammatory used as an analgesic. Synonyms: 1-Acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate; 2-Fluoro-alpha-methyl-[1,1'-biphenyl]-4-acetic acid 1-(acetyloxy)ethyl ester; [1,1'-Biphenyl]-4-acetic acid, 2-fluoro-a-methyl-, 1-(acetyloxy)ethyl ester; LFP 83; FP 83; Hurbiprofen Axetil; Lipfen; Ropiopn. Grades: > 95%. CAS No. 91503-79-6. Molecular formula: C19H19FO4. Mole weight: 330.35.
Flurbiprofen Impurity D
Flurbiprofen Impurity D is an impurity of Flurbiprofen. Synonyms: 1-(2-fluoro[1,1'-biphenyl]-4-yl)ethan-1-one; 3-Fluoro-4-phenyl acetophenone; 2-Fluoro-4-acetylbiphenyl; 4-acetyl 2-fluorobiphenyl. Grades: > 95%. CAS No. 42771-79-9. Molecular formula: C14H11FO. Mole weight: 214.24.
GR 103691
GR 103691 is a potent dopamine D3 receptor antagonist. Uses: Dopamine antagonists. Synonyms: GR 103691; GR103691; GR-103691; 4'-Acetyl-N-[4-[4-(2-methoxyphenyl)-1-piperazinyl]butyl]-[1,1'-biphenyl]-4-carboxamide. Grades: 99%. CAS No. 162408-66-4. Molecular formula: C30H35N3O3. Mole weight: 485.62.
GSK 1562590 hydrochloride
GSK 1562590 hydrochloride is a high affinity and selective urotensin II (UT) receptor antagonist (pKi = 9.14, 9.28, 9.34, 9.64 and 9.66 at monkey, human, mouse, cat and rat recombinant receptors, respectively). It displays selectivity for UT receptors over a range of GPCRs, ion channels, enzymes and neurotransmitter transporters. GSK 1562590 has been shown to inhibit human urotensin-II (hU-II)-induced contraction of isolated rat aorta in vitro and ex vivo. Synonyms: GSK 1562590 hydrochloride; GSK1562590 hydrochloride; GSK-1562590 hydrochloride; N-[(1R)-1-[3'-(Aminocarbonyl)[1,1'-biphenyl]-4-yl]-2-(1-pyrrolidinyl)ethyl]-6,7-dichloro-2,3-dihydro-N-methyl-3-oxo-4H-1,4-benzoxazine-4-acetamide hydrochloride; 3-[4-[(1R)-1-[[2-(6,7-dichloro-3-oxo-1,4-benzoxazin-4-yl)acetyl]-methylamino]-2-pyrrolidin-1-ylethyl]phenyl]benzamide hydrochloride. Grades: ≥98% by HPLC. CAS No. 1003878-07-6. Molecular formula: C30H30Cl2N4O4.HCl. Mole weight: 617.95.
JNJ-28312141
JNJ-28312141 is an orally active CSF1R inhibitor (Colony-stimulating factor-1 receptor, CRF1R) and also a FLT3 inhibitor. CSF1R is expressed by many tumors and is a growth factor for macrophages and mediates osteoclast differentiation. JNJ-28312141 represents a new agent with potential therapeutic activity in acute myeloid leukemia and in settings where CSF-1-dependent macrophages and osteoclasts contribute to tumor growth and skeletal events. Synonyms: JNJ28312141; JNJ 28312141; 4-cyano-N-(5-(1-(2-(dimethylamino)acetyl)piperidin-4-yl)-2',3',4',5'-tetrahydro-[1,1'-biphenyl]-2-yl)-1H-imidazole-2-carboxamide. CAS No. 885692-52-4. Molecular formula: C26H32N6O2. Mole weight: 460.58.
Losartan Acetate N1-(3,4,5-O-Triacetyl)glucuronide Methyl Ester is a derivative of Losartan N1-Glucuronide (L470490). A metabolite of Losartan (L470500). Group: Biochemicals. Alternative Names: 1-[5-[4'-[[2-Butyl-4-chloro-5-(acetyloxymethyl)-1H-imidazol-1-yl]methyl][1,1'-biphenyl]-2-yl]-1H-tetrazol-1-yl]-1-deoxy-3,4,5-O-triacetyl- β-D-glucopyranuronic Acid Methyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Losartan Acetate N2-(3,4,5-O-Triacetyl)glucuronide Methyl Ester is a derivative of Losartan N2-Glucuronide (L470495). A metabolite of Losartan (L470500). Group: Biochemicals. Alternative Names: 1-[5-[4'-[[2-Butyl-4-chloro-5-(acetyloxymethyl)-1H-imidazol-1-yl]methyl][1,1'-biphenyl]-2-yl]-2H-tetrazol-2-yl]-1-deoxy-(3,4,5-O-triacetyl) β-D-Glucopyranuronic Acid. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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Losartan Impurity J
O-Acetyl Losartan is a potential impurity of Losartan. Synonyms: O-Acetyl Losartan; 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol 5-Acetate. Grades: > 95%. CAS No. 1006062-27-6. Molecular formula: C24H25ClN6O2. Mole weight: 464.95.
MOZ-IN-3
MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) with IC50 value of 8 nM. It also inhibits KAT6B/MORF with IC50 value of 28 nM. MOZ-IN-3 induced cell cycle arrest in and inhibited proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM), and induced cellular senescence without causing DNA damage or displaying a general cytotoxicity effect in mouse lymphoma cells. Synonyms: WM-8014; WM 8014; WM8014; 4-fluoro-5-methyl-N'-(phenylsulfonyl)[1,1'-biphenyl]-3-carbohydrazide. Grades: ≥98%. CAS No. 2055397-18-5. Molecular formula: C20H17FN2O3S. Mole weight: 384.43.
TCS 1102 is a potent, dual orexin receptor antagonist with Ki values of 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for P-glycoprotein, which demonstrates good brain penetration when administered intraperitoneally. It were found to decrease fear and anxiety in rats 14 days after exposure to footshock. It was also found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. Uses: Tcs 1102 was found to have anxiolytic effects. Synonyms: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)-;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide;TCS 1102, TCS1102, TCS-1102;(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide. Grades: >98 %. CAS No. 916141-36-1. Molecular formula: C27H26N4O2S. Mole weight: 470.59.
VU 0365114
VU 0365114 is a selective positive allosteric modulator of M5 muscarinic acetylcholine receptor (mAChR) (EC50 = 2.7 μM for human M5, and >30 μM for M1, M2, M3 and M4, receptors). Synonyms: VU 0365114; VU0365114; VU-0365114; 1-[(1,1'-Biphenyl)-4-ylmethyl]-5-(trifluoromethoxy)-1H-indole-2,3-dione; 1-[(4-phenylphenyl)methyl]-5-(trifluoromethoxy)indole-2,3-dione. Grades: ≥98% by HPLC. CAS No. 1208222-39-2. Molecular formula: C22H14F3NO3. Mole weight: 397.35.
O-Acetyl Losartan
A potential impurity of Losartan. Group: Biochemicals. Alternative Names: 2-Butyl-4-chloro-1-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-imidazole-5-methanol 5-Acetate. Grades: Highly Purified. CAS No. 1006062-27-6. Pack Sizes: 10mg. US Biological Life Sciences.
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