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C-1. Group: Biochemicals. Grades: Purified. CAS No. 84468-24-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
C-1
C-1 is a protein kinase inhibitor selecitive for PKG, PKA and PKC (IC50 = 4, 8 and 12 μM, respectively) and is widely used as a ROCK inhibitor. Synonyms: HA 100; HA100; HA-100; 5-Piperazin-1-ylsulfonylisoquinoline; 1-(5-Isoquinolinesulfonyl)piperazine. Grades: ≥99% by HPLC. CAS No. 84468-24-6. Molecular formula: C13H15N3O2S. Mole weight: 277.34.
C-1311 is a Fms-like tyrosine kinase 3 inhibitor under the development of Antisoma. It has shown activity in experimental tumour models both in vitro and in nude mice. C-1311 can delay progression of cells through the S phase which was followed by G2 arrest at the EC(99) dose as a mitosis inhibitor. Phase I clinical trials for treatment of solid tumours and a phase II clinical trials for the treatment of breast cancer were discontinued. Uses: Anticancer agents. Synonyms: Imidacrine; XLS-002; C-1311 dihydrochloride; XLS 002; C 1311 dihydrochloride; XLS002; C1311 dihydrochloride; Symadex; Imidazoacridinone; CHEMBL3545337;5-(2-(diethylamino)ethylamino)--8-hydroxy-6H-imidazo(4,5,1-de)acridin-6-one. Grades: 98%. CAS No. 138154-55-9. Molecular formula: C20H26Cl2N4O3. Mole weight: 441.35.
C-176
C-176 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It is also a central signaling component of the intracellular DNA sensing pathway. Synonyms: STING inhibitor C 176; C176; C 176. Grades: ≥98%. CAS No. 314054-00-7. Molecular formula: C11H7IN2O4. Mole weight: 358.09.
C-176
C-176 is a selective and blood-brain barrier permeable STING inhibitor. C-176 covalently targets transmembrane cysteine residue 91 and thereby blocking activation-induced palmitoylation of STING[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 314054-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-112906.
C-178
C-178 is a highly potent and selective small-molecule antagonist of the stimulator of interferon genes (STING) protein. It binds to Cys91 on STING to block its palmitoylation and prevents recruitment and phosphorylation of TBK1 in HEK293T cells. C-178 also blocks palmitoylation (PMA)-induced clustering of STING. It inhibits the CMA-induced phosphorylation of TBK1, which is downstream protein kinase of STING. C-178 prevents the increases in Ifnb1 expression in bone marrow-derived macrophages (BMDMs). Synonyms: C178; C 178. Grades: ≥98%. CAS No. 329198-87-0. Molecular formula: C17H10N2O5. Mole weight: 322.27.
C-178
C-178 is a potent and selective covalent inhibitor of STING. C-178 binds to Cys91 and suppresses the STING responses elicited by distinct bona fide activators in mouse but not human[1].. Uses: Scientific research. Group: Signaling pathways. CAS No. 329198-87-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-123963.
C-19393 E5
It is produced by the strain of Streptomyces griseus subsp. cryophilus C-19393. C-19393 E5 has anti-gram-positive and anti-gram-negative bacteria activity and strong β-lactamase inhibition. Synonyms: Antibiotic C 19393E5; C-19393 E(5). CAS No. 83310-72-9. Molecular formula: C13H16N2O6S. Mole weight: 328.34.
C-19 steroid 1α-hydroxylase
The enzyme, characterized from the bacterium Sorangium cellulosum, is a class I cytochrome P-450, and uses ferredoxin as its electron donor. It was shown to act on several C-19 steroid substrates, including testosterone, androstenedione, testosterone-acetate and 11-oxoandrostenedione. Group: Enzymes. Synonyms: CYP260A1. Enzyme Commission Number: EC 1.14.15.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0944; C-19 steroid 1α-hydroxylase; EC 1.14.15.19; CYP260A1. Cat No: EXWM-0944.
Boc-1-aminocyclopropane-1-carboxylic acid is used as a reagent in the synthesis of pyrrolotriazinone derivatives as therapeutic PI3K inhibitors. Also used as a reagent in the synthesis of ether, carbamate and ester derivatives of adarotene as potential antitumor agents. Synonyms: Boc-Acpc-OH; 1-(Boc-amino)cyclopropanecarboxylic acid; 1-[ (TERT-BUTOXYCARBONYL) AMINO]CYCLOPROPANECARBOXYLIC ACID; 1- ( (tert-Butoxycarbonyl) amino) cyclopropanecarboxylic acid; N-Boc-1-aminocyclopropanecarboxylic acid; 1-{[(Tert-Butoxy)Carbonyl]Amino}Cyclopropane-1-Carboxylic Acid; MFCD00083257; Cyclopropanecarboxylic acid, 1-[[(1,1-dimethylethoxy)carbonyl]amino]-; 1-tert-Butoxycarbonylamino-cyclopropanecarboxylic acid; Boc ACPC OH. Grades: ≥ 99% (HPLC). CAS No. 88950-64-5. Molecular formula: C9H15NO4. Mole weight: 201.22.
CC-1065 is originally isolated from Streptomyces zelensis and its bioactivity was very strong. CC-1065 is against gram-positive bacteria with the MIC=1-10 ng/mL, against most gram-negative bacterial and fungi with the MIC of 1 μg/mL. Synonyms: Antibiotic CC 1065; NSC298223; CCRIS 2174. CAS No. 69866-21-3. Molecular formula: C37H33N7O8. Mole weight: 703.70.
CC-1088
CC-1088 is an analog of thalidomide with potential antineoplastic activity that belongs to the functional class of agents called selective cytokine inhibitory drugs (SelCIDs). Uses: Cytokine inhibitor. Synonyms: CC1088; CC 1088; CC-1088. 3-(1,3-dioxoisoindolin-2-yl)-3-phenylpropanamide. Grades: ≥98%. CAS No. 467421-06-3. Molecular formula: C17H14N2O3. Mole weight: 294.31.
CC-115
CC-115, a DNA-PK and mTOR inhibitor, has been found to have probable anticarcinoma effect. IC50:13 nM and 21 nM for DNA-PK and mTOR respectively. Uses: Cc-115 is a dna-pk and mtor inhibitor and has been found to have probable anticarcinoma effect. Synonyms: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one; CC115 ; CC-115; CC 115. Grades: 98%. CAS No. 1228013-15-7. Molecular formula: C16H16N8O. Mole weight: 336.35.
CC-115
CC-115 is a dual inhibitor of DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR), with potential antineoplastic activity. CC-115 binds to and inhibits the activity of DNA-PK and both raptor-mTOR (TOR complex 1 or TORC1) and rictor-mTOR (TOR complex 2 or TORC2), which may lead to a reduction in cellular proliferation of cancer cells expressing DNA-PK and TOR. DNA-PK, a serine/threonine kinase and a member of the PI3K-related kinase subfamily of protein kinases, is activated upon DNA damage and plays a key role in repairing double-stranded DNA breaks via the DNA nonhomologous end joining (NHEJ) pathway. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CC115 ; CC-115; CC 115. Product Category: Inhibitors. Appearance: Red solid powder. CAS No. 1228013-15-7. Molecular formula: C16H16N8O. Mole weight: 336.14. Purity: >98%. IUPACName: 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-5-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one. Canonical SMILES: O=C1CNC2=NC=C(C3=CC=C(C4=NC=NN4)N=C3C)N=C2N1CC. Product ID: ACM1228013157. Alfa Chemistry ISO 9001:2015 Certified.
CC-115
CC-115 is a potent and dual DNA-PK and mTOR kinase inhibitor with IC50s of 13 nM and 21 nM, respectively. CC-115 blocks both mTORC1 and mTORC2 signaling. Uses: Scientific research. Group: Signaling pathways. CAS No. 1228013-15-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16962.
CC-115 hydrochloride
The hydrochloride salt form of CC-115 which is a mTOR / DNA-PK inhibitor that probably has antineoplastic effect through influencing the cellular proliferation of cancer cells. IC50: 21 nM and 13 nM for mTOR and DNA-PK respectively. Uses: The hydrochloride salt form of cc-115 which is a mtor / dna-pk inhibitor that probably has antineoplastic effect through influencing the cellular proliferation of cancer cells. Synonyms: CC115 hydrochloride ; CC-115 hydrochloride; CC 115 hydrochloride. Grades: 98%. CAS No. 1300118-55-1. Molecular formula: C16H17ClN8O. Mole weight: 372.81.
CC-12074
A Metabolite of Pomalidomide. Uses: Pomalidomide metabolite. Synonyms: CC-12074; CC12074; CC 12074; Pomalidomide metabolite M19; UNII-A480CC1Z8I; SCHEMBL3742152.4-amino-2-(5-hydroxy-2,6-dioxopiperidin-3-yl)isoindole-1,3-dione. Grades: ≥98%. CAS No. 460741-57-5. Molecular formula: C13H11N3O5. Mole weight: 289.24.
CC-17368
CC-17368 is a hydroxyisoindole derivative and metabolite of pomalidomide that has potential activity in anticancer study like multiple myeloma. Synonyms: CC 17368; CC17368; Pomalidomide metabolite M17; 1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-5-hydroxy-. Grades: 98%. CAS No. 1547162-41-3. Molecular formula: C13H11N3O5. Mole weight: 289.25.
CC-17369
CC-17369, a hydroxyisoindole derivative, is a metabolites of pomalidomide and has potential activity in anticancer study like multiple myeloma. Synonyms: CC-17369; CC 17369; CC17369; Pomalidomide metabolite M16; M16(CC-17369); SCHEMBL15439588; 4-amino-2-(2,6-dioxopiperidin-3-yl)-7-hydroxyisoindole-1,3-dione. Grades: 98%. CAS No. 1547162-46-8. Molecular formula: C13H11N3O5. Mole weight: 289.25.
CGC-11047
CGC-11047 is a second generation polyamine analogue, synthesized through the restriction of molecular conformations of parent polyamine compounds, with potential antineoplastic activity. Polyamine analogue PG11047 may displace endogenous polyamines from DNA binding sites, thereby interfering with cell cycle processes dependent upon polyamine binding and function, and resulting in cell-cycle arrest, induction of apoptosis, depletion of polyamines, and interference with gene and ligand-receptor activities involved with cell growth. This agent may exhibit decreased toxicity and enhanced cytotoxicity profiles compared to first-generation polyamine compounds. In tumor cells, there is an increase dependence on polyamines as well as a dysregulated polyamine metabolic pathway resulting in abnormal or sustained tumor growth. Synonyms: CGC 11047; CGC11047; SL 11047; SL 47; SL47. CAS No. 206991-64-2. Molecular formula: C14H36Cl4N4. Mole weight: 402.27.
CUDC-101
CUDC-101 is a multi-targeted, small-molecule inhibitor of histone deacetylase (HDAC), epidermal growth factor receptor tyrosine kinase (EGFR/ErbB1), and human epidermal growth factor receptor 2 tyrosine kinase (HER2/neu or ErbB2) with potential antineoplastic activity. HDAC/EGFR/HER2 inhibitor CUDC-101 inhibits the activity of these three enzymes but the exact mechanism of action is presently unknown. This agent may help overcome resistance to inhibition of EGFR and Her2 through a simultaneous, synergistic inhibition of EGFR, Her2, and HDAC. Synonyms: CUDC101; CUDC 101; CUDC-101. CAS No. 1012054-59-9. Molecular formula: C24H26N4O4. Mole weight: 434.496.
CUDC-101
CUDC-101 is a potent inhibitor of HDAC , EGFR , and HER2 with IC 50 s of 4.4, 2.4, and 15.7 nM, respectively. CUDC-101 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. CAS No. 1012054-59-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10223.
CUDC-101
CUDC-101 is a potent multi-acting HDAC (histone deacetylase), EGFR (epidermal growth factor receptor), and HER2 ( human epidermal growth factor receptor 2) inhibitor for the treatment of cancer. Group: Biochemicals. Alternative Names: 7-[[4-[(3-Ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanamide; 7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide. Grades: Highly Purified. CAS No. 1012054-59-9. Pack Sizes: 10mg. US Biological Life Sciences.
A potent multitargeted inhibitor of histone deacetylase (HDAC) and the receptor kinases epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2), with IC?? values of 4.4, 2.4, and 15.7nm, respectively. Displays potent antiproliferative and proapoptotic activities against cultured and implanted tumor cells that are sensitive or resistant to several approved single-targeted drugs. Group: Biochemicals. Grades: Highly Purified. CAS No. 1012054-59-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
CYC-116
An Aurora kinase inhibitor, used to treat patients with advanced solid tumors. Group: Biochemicals. Alternative Names: 5-[2, 5-Dihydro-2-[[4- (4-morpholinyl) phenyl]imino]-4-pyrimidinyl]-4-methyl-2-thiazolamine. Grades: Highly Purified. CAS No. 1059105-22-4. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Cyclohexanecarboxylic-1-d1 acid
Cyclohexanecarboxylic-1-d1 acid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: CYCLOHEXANECARBOXYLIC-1-D1 ACID;Cyclohexanecarboxylic-D1 Acid. Product Category: Heterocyclic Organic Compound. CAS No. 933-37-9. Molecular formula: C7H11DO2. Mole weight: 129.18. Purity: 98 atom % D. Product ID: ACM933379. Alfa Chemistry ISO 9001:2015 Certified.
D-Fructose-13C-1
D-Fructose- 13 C-1 is the 13 C labeled D-Fructose. D-Fructose (D(-)-Fructose) is a naturally occurring monosaccharide found in many plants. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: D(-)?-Fructose- 13 C-1. CAS No. 117013-19-1. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N7092S2.
D-Glucose-1-13C-1-C-d
D-Glucose-1-13C-1-C-d. Group: Biochemicals. Alternative Names: D-Glucose-1-13C-1-C-2H. Grades: Highly Purified. CAS No. 201136-45-0. Pack Sizes: 25mg. Molecular Formula: C513CH11DO6, Molecular Weight: 182.15. US Biological Life Sciences.
Worldwide
D-Glucose-13C-1
D-Glucose- 13 C-1 is the 13 C labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. D-Glucose is a carbohydrate sweetener and critical components of the general metabolism, and serve as critical signaling molecules in relation to both cellular metabolic status and biotic and abiotic stress response[1]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: Glucose- 13 C-1; D-(+)-Glucose- 13 C-1; Dextrose- 13 C-1. CAS No. 84270-10-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-B0389S11.
Diclofenac-13C6
Diclofenac- 13 C 6 is the 13 C 6 labeled Diclofenac. Diclofenac is a potent and nonselective anti-inflammatory agent, acts as a COX inhibitor, with IC50s of 4 and 1.3 nM for human COX-1 and COX-2 in CHO cells, and 5.1 and 0.84 μM for ovine COX-1 and COX-2, respectively. Diclofenac induces apoptosis of neural stem cells (NSCs) via the activation of the caspase cascade. Uses: Scientific research. Group: Isotope-labeled compounds. CAS No. 1261393-71-8. Pack Sizes: 1 mg. Product ID: HY-15036S1.
DL-Alanine-13C-1
DL-Alanine- 13 C-1 is the 13 C-labeled DL-Alanine. DL-alanine, an amino acid, is the racemic compound of L- and D-alanine. DL-alanine is employed both as a reducing and a capping agent, used with silver nitrate aqueous solutions for the production of nanoparticles. DL-alanine can be used for the research of transition metals chelation, such as Cu(II), Zn(II), Cd(11). DL-alanine, a sweetener, is classed together with glycine, and sodium saccharin. DL-alanine plays a key role in the glucose-alanine cycle between tissues and liver[1][2][3][4][5][6]. Uses: Scientific research. Group: Isotope-labeled compounds. Alternative Names: DL-2-Aminopropionic acid- 13 C-1. CAS No. 102029-81-2. Pack Sizes: 25 mg; 50 mg; 100 mg. Product ID: HY-N2362S.
(E)-Hexadec-11-enal
(E)-Hexadec-11-enal. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (E)-Hexadec-11-enal;11-Hexadecenal;57491-33-5;(e)-11-hexadecenal;cis-11-Hexadecenal;11-Hexadecenal, (11E)-;53939-28-9;E-11-Hexadecenal;EINECS 260-765-3;AI3-36726;11-Hexadecenal, (E)-;SCHEMBL461193;SCHEMBL811762;(11E)-11-Hexadecenal #;DTXSID601016280;ZINC5509932;LMFA06000092;AKOS015901481. Appearance: Clear liquid. CAS No. 57491-33-5. Molecular formula: C16H30O. Mole weight: 238.41g/mol. Purity: 0.95. IUPACName: (E)-hexadec-11-enal. Canonical SMILES: CCCCC=CCCCCCCCCCC=O. ECNumber: 260-765-3;258-876-7. Product ID: ACM57491335. Alfa Chemistry ISO 9001:2015 Certified.