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L-DOPA (Levodopa) is an orally active metabolic precursor of neurotransmitters dopamine. L-DOPA can cross the blood-brain barrier and is converted into dopamine in the brain. L-DOPA has anti-allodynic effects and the potential for Parkinson's disease [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: Levodopa; 3,4-Dihydroxyphenylalanine. CAS No. 59-92-7. Pack Sizes: 200 mg; 1 g. Product ID: HY-N0304.
Natural isomer of the immediate precursor of dopamine; product of tyrsine hydroxylase. Group: Biochemicals. Alternative Names: Levodopd3; L-3-Hydroxytyrosine-d3; 3-Hydroxy-L-tyrosine-d3; (-)-3-(3,4-Dihydroxyphenyl-2,5,6-d3)-L-alanine; Bendopa-d3; Deadopa-d3; Dopaflex-d3; Dopal-d3; Dopaidan-d3; Dopalina-d3; Dopar-d3. Grades: Highly Purified. CAS No. 53587-29-4. Pack Sizes: 10mg. US Biological Life Sciences.
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L-DOPA (3,4-Dihydroxy-L-phenylalanine)
25g Pack Size. Group: Amino Acids, Biochemicals, Building Blocks, Stains & Indicators. Formula: C9H11NO4. CAS No. 59-92-7. Prepack ID 64811919-25g. Molecular Weight 197.19. See USA prepack pricing.
L-DOPA-4-Sulfate
L-DOPA-4-Sulfate. Group: Biochemicals. Alternative Names: 3-Hydroxy-L-tyrosine 4-(Hydrogen Sulfate). Grades: Highly Purified. CAS No. 217657-34-6. Pack Sizes: 2.5mg. Molecular Formula: C9H11NO7S, Molecular Weight: 277.25. US Biological Life Sciences.
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L-dopachrome isomerase
A zinc enzyme. Stereospecific for L-dopachrome. Dopachrome methyl ester is a substrate, but dopaminochrome (2,3-dihydroindole-5,6-quinone) is not (see also EC 4.1.1.84, D-dopachrome decarboxylase). Group: Enzymes. Synonyms: dopachrome tautomerase; tyrosinase-related protein 2; TRP-1; TRP2; TRP-2; tyrosinase-related protein-2; dopachrome Δ7,Δ2-isomerase; dopachrome Δ-isomerase; dopachrome conversion factor; dopachrome isomerase; dopachrome oxidoreductase; dopachrome-rearranging enzyme; DCF; DCT; dopachrome keto-enol isomerase; L-dopachrome-methyl ester tautomerase. Enzyme Commission Number: EC 5.3.3.12. CAS No. 130122-81-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5492; L-dopachrome isomerase; EC 5.3.3.12; 130122-81-5; dopachrome tautomerase; tyrosinase-related protein 2; TRP-1; TRP2; TRP-2; tyrosinase-related protein-2; dopachrome Δ7,Δ2-isomerase; dopachrome Δ-isomerase; dopachrome conversion factor; dopachrome isomerase; dopachrome oxidoreductase; dopachrome-rearranging enzyme; DCF; DCT; dopachrome keto-enol isomerase; L-dopachrome-methyl ester tautomerase. Cat No: EXWM-5492.
L-Dopa ethyl ester hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: L-Dopa Ethyl Ester Hydrochloride; Levodopa Ethyl Ester Hydrochloride; O-Ethyl-DOPA Hydrochloride; 3,4-Dihydroxy-L-phenylalanine Ethyl Ester Hydrochloride; 3-Hydroxy-L-tyrosine Ethyl Ester Hydrochloride. Product Category: Heterocyclic Organic Compound. Appearance: Off-White Solid. CAS No. 39740-30-2. Molecular formula: C11H16ClNO4. Mole weight: 261.7. Purity: 0.96. IUPACName: ethyl(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate;hydrochloride. Canonical SMILES: CCOC(=O)C(CC1=CC(=C(C=C1)O)O)N.Cl. Product ID: ACM39740302. Alfa Chemistry ISO 9001:2015 Certified.
L-DOPA Ethyl Ester Hydrochloride
An active ingredient in preparations for the treatment of Parkinsons disease. Group: Biochemicals. Alternative Names: L-Dopa Ethyl Ester Hydrochloride; Levodopa Ethyl Ester Hydrochloride; O-Ethyl-DOPA Hydrochloride; 3,4-Dihydroxy-L-phenylalanine Ethyl Ester Hydrochloride; 3-Hydroxy-L-tyrosine Ethyl Ester Hydrochloride. Grades: Highly Purified. CAS No. 39740-30-2. Pack Sizes: 1g. US Biological Life Sciences.
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L-DOPA isopropyl ester
L-DOPA isopropyl ester. Group: Biochemicals. Alternative Names: 3-Hydroxy-L-tyrosine 1-methylethyl ester; 3-Hydroxy-L-tyrosine isopropyl ester. Grades: Highly Purified. CAS No. 110301-07-0. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C12H17NO4. US Biological Life Sciences.
L-DOPA n-butyl ester. Group: Biochemicals. Alternative Names: L-DOPA butyl ester; 3-Hydroxy-L-tyrosine butyl ester. Grades: Highly Purified. CAS No. 39638-52-3. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C13H19NO4. US Biological Life Sciences.
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L-Dopa-(phenyl-d3)
?98 atom % D, ?98% (CP). Group: Fluorescence/luminescence spectroscopy.
3,4-Di-O-(b-D-glucopyranosyl)-L-DOPA
3,4-Di-O-(b-D-glucopyranosyl)-L-DOPA is an exquisite derivative of L-DOPA renowned for its efficacy in research of neurodegenerative disorders, specifically the formidable Parkinson's disease. Synonyms: 3,4-Di-O-(b-D-glucopyranosyl)-L-dihydroxyphenylalanine.
3',4'-Di-O-(b-D-glucopyranosyl)-L-DOPA
3',4'-Di-O-(b-D-glucopyranosyl)-L-DOPA is a biomedical marvel extensively utilized in managing the debilitating symptoms of Parkinson's disease. Serving as a pivotal precursor to dopamine, an intricate neurotransmitter intimately related to motor regulation, this extraordinary compound guarantees unparalleled therapeutic benefits. Synonyms: 3',4'-Di-O-(b-D-glucopyranosyl)-L-dihydroxyphenylalanine.
3-O-(b-D-Glucopyranosyl)-L-DOPA
3-O-(b-D-Glucopyranosyl)-L-DOPA is a bioactive compound, holding immense potential in research of Parkinson's disease. As a derivative of the precursor L-DOPA, it intricately intertwines with the metabolic process, enhancing its bioavailability. Molecular formula: C15H21NO9. Mole weight: 359.33.
3'-O-(b-D-Glucopyranosyl)-L-DOPA
3'-O-(b-D-Glucopyranosyl)-L-DOPA, a well-known compound within the biomedical industry, serves a pivotal function in the treatment of Parkinson's disease by acting as a precursor for dopamine synthesis in the brain. By effectively heightening dopamine levels, it exhibits the capacity to enhance motor symptoms and overall quality of life for patients. Molecular formula: C15H21NO9. Mole weight: 359.33.
3-O-Methyl-L-DOPA-d3 Methyl Ester
Protected labeled 3-O-Methyl-L-DOPA. 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-Methoxy-d3-L-tyrosine Methyl Ester. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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3-O-Methyl-L-DOPA-d3 Monohydrate
Labeled 3-O-Methyl-L-DOPA. 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-(Methoxy-d3)-L-tyrosine Monohydrate; 3-(Methoxy-d3)-4-hydroxyphenylalanine Monohydrate; 3-(Methoxy-d3)-DOPA Monohydrate; 3-(Methoxy-d3)-L-tyrosine Monohydrate; 3-O-(Methyl-d3)dopa Monohydrate; L-3-(Methoxy-d3)-4-hydroxy-phenylalanine Monohydrate; L-3-O-(Methyl-d3)-DOPA Monohydrate; L-4-Hydroxy-3-(methoxy-d3)phenylalanine Monohydrate. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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3-O-Methyl-L-DOPA Methyl Ester
Protected 3-O-Methyl-L-DOPA. 3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-Methoxy-L-tyrosine Methyl Ester. Grades: Highly Purified. CAS No. 78148-37-5. Pack Sizes: 25mg. US Biological Life Sciences.
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3-O-Methyl L-DOPA monohydrate
3-O-Methyl L-DOPA monohydrate. Group: Biochemicals. Alternative Names: 3-Methoxy-L-tyrosine monohydrate. Grades: Highly Purified. CAS No. 200630-46-2. Pack Sizes: 10mg, 25mg, 50mg, 100mg, 250mg. Molecular Formula: C10H15NO5. US Biological Life Sciences.
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3-O-Methyl-L-DOPA Monohydrate
3-O-Methyl-L-DOPA is the major metabolite of L-DOPA via catechol O-methyltransferase (COMT). 3-Methoxy-L-tyrosine is neither a substrate for nor an inhibitor of L-amino acid decarboxylase activity. Inhibition of COMT enhances the anti-Parkinson activity of L-DOPA. Group: Biochemicals. Alternative Names: 3-Methoxy-L-tyrosine Monohydrate; 3-Methoxy-4-hydroxyphenylalanine Monohydrate; 3-Methoxy-DOPA Monohydrate; 3-Methoxy-L-tyrosine Monohydrate; 3-O-Methyldopa Monohydrate; L-3-Methoxy-4-hydroxyphenylalanine Monohydrate; L-3-O-Methyl-DOPA Monohydrate; L-4-Hydroxy-3-methoxyphenylalanine Monohydrate. Grades: Highly Purified. CAS No. 200630-46-2. Pack Sizes: 10mg, 25mg, 50mg. US Biological Life Sciences.
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4-O-(b-D-Glucopyranosyl)-L-DOPA
4-O-(b-D-Glucopyranosyl)-L-DOPA is an imperative pharmacological compound, finding applications in the research of Parkinson's disease. Serving as a fundamental building block for dopamine is a neurotransmitter responsible for regulating motor control, this compound effectively bolsters dopamine research and development and availability. Synonyms: p-glc-DOPA. Molecular formula: C15H21NO9. Mole weight: 359.33.
4'-O-(b-D-Glucopyranosyl)-L-DOPA
4'-O-(b-D-Glucopyranosyl)-L-DOPA, a remarkable biomedical compound, showcases its indispensability in the therapeutic intervention of Parkinson's disease. Leveraging its distinctive configuration, it espouses escalated solubility, stability, and bioavailability, thereby manifesting an elevated therapeutic potency. As a precursor to dopamine, this compound orchestrates reinvigoration of cerebral dopamine levels, ameliorating the motor symptoms that conventionally plague Parkinson's disease. Synonyms: p-glc-DOPA. Molecular formula: C15H21NO9. Mole weight: 359.33.
Intermediate in the preparation of a L-DOPA metabolite. Group: Biochemicals. Alternative Names: 3-Acetyloxy-N-[ (phenylmethoxy) carbonyl]-O- (phenylmethyl) -L-tyrosine Methyl Ester. Grades: Highly Purified. Pack Sizes: 100mg. US Biological Life Sciences.
Intermediate in the preparation of a labeled L-DOPA metabolite. Group: Biochemicals. Alternative Names: 3-Methoxy-N-[ (phenylmethoxy) carbonyl]-O- (phenylmethyl) -L-tyrosine-d3 Methyl Ester. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
Intermediate in the preparation of a L-DOPA metabolite. Group: Biochemicals. Alternative Names: 3-Methoxy-N-[ (phenylmethoxy) carbonyl]-O- (phenylmethyl) -L-tyrosine Methyl Ester. Grades: Highly Purified. CAS No. 881911-31-5. Pack Sizes: 50mg. US Biological Life Sciences.
Intermediate in the preparation of a L-DOPA metabolite. Group: Biochemicals. Alternative Names: 3-Hydroxy-N-[ (phenylmethoxy) carbonyl]-O- (phenylmethyl) -L-tyrosine Methyl Ester. Grades: Highly Purified. CAS No. 105229-41-2. Pack Sizes: 100mg. US Biological Life Sciences.
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6-Fluoro L-DOPA Hydrobromide Salt
A fluorinated DOPA analog. Group: Biochemicals. Alternative Names: 2-Fluoro-5-hydroxy-L-tyrosine Hydrobromide; 6-Fluoro-L-dopa Hydrobromide; 6-Fluoro DOPA Hydrobromide. Grades: Highly Purified. CAS No. 154051-94-2. Pack Sizes: 5mg. US Biological Life Sciences.
2-Amino-5,6,7,8-tetrahydro-6-methyl-4(1H)-pteridinone is an analog of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases. It is also used to study mechanisms of nitric oxide (NO) synthase and free radical induced L-DOPA release from striatal tissue. Group: Biochemicals. Grades: Highly Purified. CAS No. 69113-63-9. Pack Sizes: 100mg, 1g. Molecular Formula: C7H13Cl2N5O, Molecular Weight: 254.12. US Biological Life Sciences.
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2-Nitro-L-phenylalanine
2-Nitro-L-phenylalanine is a derivative of L-phenylalanine, and is used in the photocleavage of polypeptide backbones. L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. Synonyms: H-Phe(2-NO2)-OH; L-3-(o-Nitrophenyl)-alanine; L-2-Nitrophenylalanine. Grades: ≥ 99% (HPLC, Chiral purity). CAS No. 19883-75-1. Molecular formula: C9H10N2O4. Mole weight: 210.19.
Intermediate in the preparation of fluoro-labeled L-DOPA. Group: Biochemicals. Alternative Names: 2-[[ (1, 1-Dimethylethoxy) carbonyl]amino]-3- (2-fluoro-4, 5-dimethoxyphenyl) -2-Propenoic Acid Methyl Ester. Grades: Highly Purified. CAS No. 853759-47-4. Pack Sizes: 25mg. US Biological Life Sciences.
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3,4-Dihydroxy-L-phenylalanine
3,4-Dihydroxy-L-phenylalanine. Uses: 3,4-dihydroxy-l-phenylalanine or l-dopa has been used to stain melanocytes. it has also been used to study its effects on a drosophila model of parkinson's disease. Additional or Alternative Names: 3-(3,4-Dihydroxyphenyl)-L-alanine, L-3-Hydroxytyrosine, L-DOPA, Levodopa. Product Category: Amino Acids. CAS No. 59-92-7. Molecular formula: (HO)2C6H3CH2CH(NH2)CO2H. Mole weight: 197.19. Canonical SMILES: N[C@@H](Cc1ccc(O)c(O)c1)C(O)=O. ECNumber: 200-445-2. Product ID: ACM59927-2. Alfa Chemistry ISO 9001:2015 Certified.
This enzyme is one of the three enzymes involved in L-dopa (3,4-dihydroxy-L-phenylalanine) catabolism in the non-oxygenic phototrophic bacterium Rubrivivax benzoatilyticus OU5 (and not Rhodobacter sphaeroides OU5 as had been thought), the other two being EC 4.3.1.22 (dihydroxyphenylalanine reductive deaminase) and EC 2.6.1.49 (3,4-dihydroxyphenylalanine transaminase). In addition to L-dopa, the enzyme can also use L-tyrosine, L-phenylalanine, L-tryptophan and glutamate as substrate, but more slowly. The enzyme is inhibited by NADH and 2-oxoglutarate. Group: Enzymes. Synonyms: 3,4-dihydroxy-L-phenylalanine: oxidative deaminase; oxidative deaminase; DOPA oxidative deaminase; DOPAODA. Enzyme Commission Number: EC 1.13.12.15. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0607; 3,4-dihydroxyphenylalanine oxidative deaminase; EC 1.13.12.15; 3,4-dihydroxy-L-phenylalanine: oxidative deaminase; oxidative deaminase; DOPA oxidative deaminase; DOPAODA. Cat No: EXWM-0607.
3,4-Dihydroxypyridine
3,4-Dihydroxypyridine is a chemical compound with a structure consisting of a pyridine ring with hydroxyl groups (OH) attached at the 3rd and 4th positions. This compound is a derivative of pyridine and belongs to the class of heterocyclic compounds. Uses: 3,4-dihydroxypyridine is used in the synthesis of various pharmaceuticals and organic compounds. one of its important applications is in the production of the drug called l-dopa (levodopa), which is used in the treatment of parkinson's disease. Additional or Alternative Names: 3,4-pyridinediol;3,4-DIHYDROXYPYRIDINE;3,4-DIHYDROXYPYRIDINE 99%;Pyridine-3,4-diol;pyridin-3,4-diol. Appearance: Brown solid. CAS No. 10182-48-6. Molecular formula: C5H5NO2. Mole weight: 111.1. Purity: 0.95. IUPACName: pyridine-3,4-diol. Canonical SMILES: OC1=CC=NC=C1O. Density: 1.4±0.1 g/mL. Product ID: ACM10182486. Alfa Chemistry ISO 9001:2015 Certified.
3-Acetyl-L-tyrosine Methyl Ester Hydrochloride
An acetylated L-Tyrosine derivative. Used in the preparation of 3-O-Methyl-L-DOPA Monohydrate, a major metabolite of L-DOPA. Group: Biochemicals. Grades: Highly Purified. CAS No. 57085-32-2. Pack Sizes: 500mg. US Biological Life Sciences.
Protected L-DOPA derivative. Group: Biochemicals. Alternative Names: 3-Acetyl-N-[ (phenylmethoxy) carbonyl]-L-tyrosine Methyl Ester. Grades: Highly Purified. CAS No. 110774-03-3. Pack Sizes: 250mg. US Biological Life Sciences.
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3-O-Methyldopa
3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine [1]. Uses: Scientific research. Group: Natural products. Alternative Names: 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA. CAS No. 300-48-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-113468A.
3-O-Methyldopa monohydrate
3-O-Methyldopa monohydrate (3-Methoxy-L-tyrosine monohydrate) is a significant metabolite of L-DOPA produced through the action of catechol O-methyltransferase (COMT). Unlike its precursor, 3-O-Methyldopa does not serve as a substrate or inhibitor of L-amino acid decarboxylase activity. Additionally, the inhibition of COMT can amplify the anti-Parkinson effects of L-DOPA. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 3-Methoxy-L-tyrosine monohydrate; 3-O-Methyl-L-DOPA monohydrate. CAS No. 200630-46-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-W012264.
4-Amino-3,6-disulfo-1,8-naphthalic Anhydride Dipotassium Salt
4-Amino-3,6-disulfo-1,8-naphthalic anhydride dipotassium salt is a useful dye for biological research purposes. It is a building block to water soluble polar tracer such as lucifer yellow probes and it can also be used as reagent/reactant in three-point recognition and selective fluorescence sensing of L-DOPA. Group: Biochemicals. Grades: Highly Purified. CAS No. 79539-35-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C12H7K2NO9S2, Molecular Weight: 451.51. US Biological Life Sciences.
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aromatic-L-amino-acid decarboxylase
A pyridoxal-phosphate protein. The enzyme also acts on some other aromatic L-amino acids, including L-tryptophan, L-tyrosine and L-phenylalanine. Group: Enzymes. Synonyms: DOPA decarboxylase; tryptophan decarboxylase; hydroxytryptophan decarboxylase; L-DOPA decarboxylase; aromatic amino acid decarboxylase; 5-hydroxytryptophan decarboxylase; aromatic-L-amino-acid carboxy-lyase (tryptamine-forming). Enzyme Commission Number: EC 4.1.1.28. CAS No. 9042-64-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4771; aromatic-L-amino-acid decarboxylase; EC 4.1.1.28; 9042-64-2; DOPA decarboxylase; tryptophan decarboxylase; hydroxytryptophan decarboxylase; L-DOPA decarboxylase; aromatic amino acid decarboxylase; 5-hydroxytryptophan decarboxylase; aromatic-L-amino-acid carboxy-lyase (tryptamine-forming). Cat No: EXWM-4771.
D-dopachrome decarboxylase
This enzyme is specific for D-dopachrome as substrate and belongs to the MIF (macrophage migration inhibitory factor) family of proteins. L-Dopachrome, L- or D-α-methyldopachrome and dopaminochrome do not act as substrates (see also EC 5.3.3.12, L-dopachrome isomerase). Group: Enzymes. Synonyms: phenylpyruvate tautomerase II; D-tautomerase;D-dopachrome tautomerase; D-dopachrome carboxy-lyase. Enzyme Commission Number: EC 4.1.1.84. CAS No. 184111-06-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4833; D-dopachrome decarboxylase; EC 4.1.1.84; 184111-06-6; phenylpyruvate tautomerase II; D-tautomerase;D-dopachrome tautomerase; D-dopachrome carboxy-lyase. Cat No: EXWM-4833.
dihydroxyphenylalanine transaminase
A pyridoxal-phosphate protein. Group: Enzymes. Synonyms: dopa transaminase; dihydroxyphenylalanine aminotransferase; aspartate-DOPP transaminase (ADT); L-dopa transaminase; dopa aminotransferase; glutamate-DOPP transaminase (GDT); phenylalanine-DOPP transaminase (PDT); DOPA 2-oxoglutarate aminotransferase; DOPAATS. Enzyme Commission Number: EC 2.6.1.49. CAS No. 37277-98-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2890; dihydroxyphenylalanine transaminase; EC 2.6.1.49; 37277-98-8; dopa transaminase; dihydroxyphenylalanine aminotransferase; aspartate-DOPP transaminase (ADT); L-dopa transaminase; dopa aminotransferase; glutamate-DOPP transaminase (GDT); phenylalanine-DOPP transaminase (PDT); DOPA 2-oxoglutarate aminotransferase; DOPAATS. Cat No: EXWM-2890.
Eltoprazine
Eltoprazine belongs the phenylpiperazine class which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It is closely related to fluprazine and batoprazine, which are similarly acting drugs. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It was found to (synergistically) potentiate the antidyskinetic effect of amantadine. It has been shown to reduce 5-HIAA levels in the striatum and exhibits antiaggressive behavior in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-;1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine;DU-28853;DU28853. Grades: >98 %. CAS No. 98224-03-4. Molecular formula: C12H16N2O2. Mole weight: 220.27.
Eltoprazine hydrochloride
Eltoprazine hydrochloride is the hydrochloride form of Eltoprazine which is a serenic or antiaggressive agent. It acts as an agonist at the 5-HT1A and 5-HT1B receptors and as an antagonist at the 5-HT2C receptor with Ki values of 40, 52 and 81 nM for 5-HT1A, 5-HT1B and 5-HT2C receptors respectively. It has been shown to reduce L-DOPA-induced dyskinesias in experimental models of Parkinson's Disease and in human patients, although this effect was accompanied by a partial worsening of the therapeutic effect of l-dopa in vivo. It is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. It was developed by PsychoGenics and Amarantus Bioscience, Inc. It is in clinical stage 3. Uses: Eltoprazine hydrochloride has been shown to reduce l-dopa-induced dyskinesias in experimental models of parkinson's disease and in human patients. it is used as a novel drug for the treatment of anxiety as well as other neurological and mental disorders. Synonyms: Piperazine, 1-(2,3-dihydro-1,4-benzodioxin-5-yl)-, monohydrochloride;1-(2,3-dihydro-1,4-benzodioxin-5-yl)piperazine hydrochloride;DU-28853 hydrochloride;DU28853 hydrochloride. Grades: >98 %. CAS No. 98206-09-8. Molecular formula: C12H17N2O2Cl. Mole weight: 256.73.
Etilevodopa
Etilevodopa (L-Dopa ethyl ester), an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-DOPA ethyl ester; Levodopa ethyl ester. CAS No. 37178-37-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-116016.
Etilevodopa hydrochloride
Etilevodopa (L-Dopa ethyl ester) hydrochloride, an ethyl-ester proagent of Levodopa, is rapidly hydrolyzed to Levodopa and ethanol by nonspecific esterases in the gastrointestinal tract. Etilevodopa hydrochloride is used for the treatment of Parkinson disease (PD). Levodopa is the direct precursor of dopamine and is a suitable proagent as it facilitates CNS penetration and delivers dopamine [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: L-DOPA ethyl ester hydrochloride; Levodopa ethyl ester hydrochloride. CAS No. 39740-30-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-116016A.
Fmoc-3,4-dihydroxy-L-phenylalanine
Fmoc-DOPA is a synthetic derivative of L-DOPA, a naturally occurring amino acid that is a precursor to dopamine and other catecholamines. It is synthesized by attaching a fluorenylmethoxycarbonyl (Fmoc) group to the amino group of DOPA, which results in increased solubility and stability. Fmoc-DOPA has been widely used in peptide synthesis and as a building block in the preparation of bioconjugates due to its unique chemical and physical properties. Uses: Fmoc-dopa has been widely used in peptide synthesis and as a building block in the preparation of bioconjugates. it has also been studied for its potential use in tissue engineering and regenerative medicine, due to its ability to promote cell adhesion and differentiation. fmoc-dopa has also been studied for its potential use in drug delivery, due to its ability to cross the blood-brain barrier. Additional or Alternative Names: (R)-Fmoc-nipecotic acid, (R)-N-Fmoc-piperidine-3-carboxylic acid, (r)-fmoc-piperidine-3-carboxylic acid, N-(9-fluorenylmethyloxycarbonyl)-3,4-dihydroxy-L-phenylalanine, (R)-Fmoc-Nip-OH, (r)-1-fmoc-piperidine-3-carboxylic acid, Fmoc-L-DOPA. Product Category: Amino Acids. CAS No. 137018-93-0. Molecular formula: C24H21NO6. Mole weight: 419.4. Purity: Peak Area by HPLC ≥95%. IUPACName: (2S)-3-(3,4-dihydroxyphenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)propanoic acid. Canonical SMILES: C1=CC=C2C(=C1)C(C3=CC=CC=C32)COC(=O)NC(CC4=C
Halxazone
It is produced by the strain of Streptomyces halstedii 4029-SVS1. It is a substance that protects nerve cells. It protects PC12 cells from L-DOPA (50 X 10-6 mol/L) toxicity, and EG50 is 15.4 nmol/L. It also protects N18-RE105 cells from L-glutamate toxicity, and EG50 is 19.1 nmol/L. Synonyms: 1-Methoxy-8-hydroxy-methyl-3H-phenoxazin-3-one. Molecular formula: C14H11NO4. Mole weight: 257.24.
Harmane
Harmane is a benzodiazepine receptor inhibitor ( IC 50 =7 μM), with IC 50 values for mACh , Opioid Receptor , MAO-A/B , and α2-adrenergic receptor of 24 μM, 2.8 μM, 0.5 μM, 5 μM, and 18 μM, respectively. Harmane inhibits the I1 imidazoline receptor ( IC 50 = 30 nM) to reduce blood pressure and has antidepressant, anti-anxiety, anticonvulsant, and analgesic effects. Harmane inhibits dopamine biosynthesis by decreasing tyrosine hydroxylase (TH) activity and enhancing L-DOPA-induced cytotoxicity in PC12 cells. Additionally, Harmane can increase the mutagenic effect induced by 2-acetylaminofluorene (AAF) [1] [2] [3] [4] [5] [6]. Uses: Scientific research. Group: Natural products. CAS No. 486-84-0. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-101392.
Idazoxan hydrochloride
Idazoxan hydrochloride (RX 781094 hydrochloride) is an α 2 -adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinsons disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RX 781094 hydrochloride. CAS No. 79944-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-14561A.
Levodopa
Levodopa is used as a cell adhesion molecule in serum-free cultures of anchorage-dependent mammalian cells! Keep container tightly closed in a dry and well-ventilated place. Uses: Antiparkinsonism. Synonyms: BETA-(3,4-DIHYDROXYPHENYL)-L-ALANINE; HYDROXYTYROSINE; H-PHE(3,4-DI-HYDROXY)-OH; H-PHE(3,4-DI-OH)-OH; H-TYR(3-HYDROXY)-OH; L-BETA-(3,4-DIHYDROXYPHENYL)ALANINE; L-DOPA; L-DOPA, L-3-HYDROXYTYROSINE. Grades: >98%. CAS No. 59-92-7. Molecular formula: C9H11NO4. Mole weight: 197.19.
Labeled analogue of L-Phenylalanine, an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame. Group: Biochemicals. Alternative Names: (2S)-2-Amino-3-phenylpropanoic Acid-13C6; (S)-(-)-Phenylalanine-13C6; (S)-α-Amino- β-phenylpropionic Acid-13C6; (S)-α-Aminohydrocinnamic Acid-13C6; (S)-α-Amino-benzenepropanoic Acid-13C6. Grades: Highly Purified. Pack Sizes: 2.5mg. US Biological Life Sciences.
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L-Phenylalanine-d5
Labeled L-Phenylalanine is an essential amino acid. L-Phenylalanine is biologically converted into L-tyrosine, another one of the DNA-encoded amino acids, which in turn is converted to L-DOPA and further converted into dopamine, norepinephrine, and epinephrine. L-Phenylalanine is produced for medical, feed, and nutritional applications such as in the preparation of Aspartame. Group: Biochemicals. Alternative Names: (2S)-2-Amino-3-phenylpropanoic Acid-d5; (S)-(-)-Phenylalanine-d5; (S)-α-Amino- β-phenylpropionic Acid-d5; (S)-α-Aminohydrocinnamic Acid-d5; (S)-α-Amino-benzenepropanoic Acid-d5. Grades: Highly Purified. CAS No. 56253-90-8. Pack Sizes: 10mg. US Biological Life Sciences.
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L-Tyrosine
L-Tyrosine is an important nutrient essential amino acid, which plays an important role in human and animal metabolism, growth and development, and is widely used in food, feed, medicine and chemical industry. It is often used as raw material for preparation of polypeptide hormones, antibiotics, L-dopa, melanin, p-hydroxycinnamic acid, p-hydroxystyrene and other pharmaceutical and chemical products. CAS No. 60-18-4. Product ID: PAP-0022. Molecular formula: C9H11NO3. Category: Amino acid. Product Keywords: Amino Acid Series; L-Tyrosine; PAP-0022; Amino acid; C9H11NO3; 60-18-4. Grade: Pharmaceutical Grade. Color: White to Pale-brown. EC Number: 200-460-4. Physical State: powder. Solubility: 1 M HCl: 25 mg/mL. Storage: Store below +30°C. Boiling Point: 314.29°C (rough estimate). Melting Point: >300 °C (dec.) (lit.). Density: 1.34.
L-Tyrosine-13C6
Labeled analogue of L-Tyrosine, one of the 22 proteinogenic amino acids that are used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine. Group: Biochemicals. Alternative Names: (-)-α-Amino-p-hydroxyhydrocinnamic Acid-13C6; Therigon-13C6; p-Tyrosine-13C6; (2S) -2-Amino-3- (4-hydroxyphenyl) propanoic Acid-13C6; (S) -2-Amino-3- (4-hydroxyphenyl) propanoic Acid-13C6; (S)-Tyrosine-13C6; (S) - α -Amino-4-hydroxy Benzene propanoic Acid-13C6; L-(-)-Tyrosine-13C6; NSC 82624-13C6; NSC 9973-13C6. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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Mavoglurant
Mavoglurant (AFQ056) is a potent, selective, non-competitive and orally active mGluR5 antagonist, with an IC 50 of 30 nM. Mavoglurant shows a >300 fold selectivity for the mGluR5 over all targets (238) tested. Mavoglurant can be used for the research of Fragile X syndrome (FXS), and L-dopa induced dyskinesias in Parkinson's disease [1] [1] [2]. Mavoglurant is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AFQ056. CAS No. 543906-09-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15257.
MK-351 hydrochloride
MK-351 hydrochloride is an alpha-adrenergic agonist selective for α2-adrenergic receptors. It is a psychoactive drug used as a sympatholytic or antihypertensive. It plays a role in treating hypertension and gestational hypertension. It has a dual mechanism of action. It is a competitive inhibitor of the enzyme DOPA decarboxylase, which converts L-DOPA into dopamine. It is converted to α-methylnorepinephrine by dopamine beta-hydroxylase. Uses: Mk-351 hydrochloride is a psychoactive drug used as a sympatholytic or antihypertensive. it plays a role in treating hypertension and gestational hypertension. Synonyms: MK-351 hydrochloride; MK 351 hydrochloride; MK351 hydrochloride; Alpha-Methyldopa hydrochloride;L-(-)-A-Methyldopa hydrochloride;Alpha-Methyldopa HCl;(2S)-2-amino-3-(3,4-dihydroxyphenyl)-2-methylpropanoic acid;3-Hydroxy-alpha-methyl-L-tyrosine hydrochloride;L-Tyrosine, 3-hydroxy-alpha-methyl-, hydrochloride;Methyldopa hydrochloride. Grades: >98 %. CAS No. 884-39-9. Molecular formula: C10H14ClNO4. Mole weight: 247.68.
N-Benzyl-L-tyrosine
Protected L-Tyrosine , an amino acid, used by cells to synthesize proteins. L-Tyrosine is biologically converted from L-phenylalanine and is in turn is converted to L-DOPA and further converted into the neurotransmitters: dopamine, norepinephrine, and epinephrine. Group: Biochemicals. Alternative Names: N-(Phenylmethyl)-L-tyrosine. Grades: Highly Purified. CAS No. 75768-66-0. Pack Sizes: 100mg. US Biological Life Sciences.
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Nebicapone
Nebicapone (BIA 3-202), a reversible catechol-O-methyltransferase (COMT) inhibitor, is mainly metabolized by glucuronidation. Nebicapone is mainly peripherally acting inhibitor that decreases the biotransformation of L-DOPA to 3-O-methyl-DOPA by inhibition of COMT, and it is potential for the treatment of Parkinson's disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BIA 3-202. CAS No. 274925-86-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106405.
OSU 6162 hydrochloride
OSU 6162 hydrochloride is a dopamine stabilizer. It is highly active on dopamine synthesis and turnover. It can antagonize the expression of L-DOPA induced behavioral sensitization. Uses: Dopamine d2 receptor antagonists. Synonyms: (S)-3-(3-(Methylsulfonyl)phenyl)-1-propylpiperidine hydrochloride; Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, hydrochloride (1:1), (3S)-; PNU 96391; PNU96391; PNU-96391; Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, monohydrochloride, (3S)-; Piperidine, 3-[3-(methylsulfonyl)phenyl]-1-propyl-, hydrochloride, (S)-; (-)-OSU 61612; OSU 6162; OSU 6162 monohydrochloride. Grades: ≥98% by HPLC. CAS No. 156907-84-5. Molecular formula: C15H23NO2S.HCl. Mole weight: 317.87.
Palmitoyl serotonin
Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, an antagonist of FAAH. Study has shown that palmitoyl serotonin attenuates the development of L-DOPA-induced dyskinesia (LID) and enhance of ERK1/2 phosphorylation and FosB/ΔFosB expression in the hemi-parkinsonian mouse model. Synonyms: N-[2-(5-hydroxy-1H-indol-3-yl)ethyl]hexadecanamide; Palmitoylserotonin. Grades: ≥98%. CAS No. 212707-51-2. Molecular formula: C26H42N2O2. Mole weight: 414.6.
R-(+)-Carbidopa
R-(+)-Carbidopa is an inhibitor of DOPA decarboxylase, which in turn plays a significant role in the prevention of the conversion of L-DOPA to dopamine. Studies has also indicated the inhibitory effects of towards L-DOPA in human liver prepns and as well as 5-hydroxytryptophan. Group: Biochemicals. Alternative Names: α-Hydrazino-3,4-dihydroxy-α-methyl-benzenepropanoic Acid;D-α-hydrazino-3,4-dihydroxy-α-methyl-hydrocinnamic Acid;MK485. Grades: Highly Purified. CAS No. 28875-92-5. Pack Sizes: 1mg, 5mg. Molecular Formula: C??H??N?O?, Molecular Weight: 226.1. US Biological Life Sciences.
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Sarizotan HCl
Sarizotan, also known as EMD-128130, is a full 5-HT1a agonist and a dopamine D2-like agonist/partial agonist used in clinical trials for the treatment of l-dopa-induced dyskinesia. Synonyms: 1-[(2R)-3,4-dihydro-2H-chromen-2-yl]-N-[[5-(4-fluorophenyl)pyridin-3-yl]methyl]methanamine;hydrochloride; EMD128130; sarizotan; 177976-12-4 (Sarizotan 2 HCl salt); 351862-32-3 (Sarizotan free base); sarizotan hydrochloride. Grades: >98%. CAS No. 195068-07-6. Molecular formula: C22H22ClFN2O. Mole weight: 384.88.
(S)-(-)-Carbidopa
(S)-(-)-Carbidopa is a peripheral decarboxylase inhibitor that is commonly used in combination with L-DOPA for treatment of Parkinsonism. S(-)-Carbidopa ( has also been shown to prolong the elimination half-life of L-DOPA from blood plasma and skeletal muscle. Group: Biochemicals. Alternative Names: (αS)-α-Hydrazino-3,4-dihydroxy-α-methylbenzenepropanoic Acid; (-)-L-α-Hydrazino-3,4-dihydroxy-α-methylhydrocinamic Acid; (S)-Carbidopa; 1-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic Acid; Carbidopa; HMD; Hydrazino-α-methyldopa; L-3-(3,4-Dihydroxyphenyl)-2-methyl-2-hydrazinopropionic Acid; L-α-(3,4-Dihydroxybenzyl)-α-hydrazinopropionic Acid; L-α-Methyl- β-(3,4-dihydroxyphenyl)-α-hydrazinopropionic Acid; L-α-Methyldopahydrazine; Lodosin; Lodosyn; MK 486; N-Aminomethyldopa; α-Hydrazino-α-methyl- β - (3, 4-dihydroxyphenyl) propionic Acid; α-Methyldopahydrazine. Grades: Highly Purified. CAS No. 28860-95-9. Pack Sizes: 1g. US Biological Life Sciences.
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TCS 46b
TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 = 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes, respectively). TCS 46b potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Synonyms: 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-; 1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-2H-benzimidazol-2-one; 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propynyl]-; 5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one; TCS 46B. Grades: ≥98% by HPLC. CAS No. 302799-86-6. Molecular formula: C22H23N3O. Mole weight: 345.44.
Tyrosinase-related protein-2 (180-188)
Tyrosinase-related protein-2 (180-188) is amino acids 180 to 188 fragment of Tyrosinase-related protein-2. TRP2 peptide, also named L-dopachrome tautomerase, H-2KB or DCT, is an immunopotientor for Melanoma, Neoplasms and Glioma.
VU 0364770
VU 0364770 is systemically active positive allosteric modulator (PAM) of metabotropic glutamate receptor subtype 4 (mGluR4) (EC50: 290 nM). It showed efficacy alone or when administered in combination with L-DOPA or an adenosine 2A (A2A) receptor antagonist, in several rodent PD models. Synonyms: VU0364770; VU-0364770; N-(3-chlorophenyl)picolinamide; N-(3-chlorophenyl)-2-pyridinecarboxamide. Grades: >98%. CAS No. 61350-00-3. Molecular formula: C12H9ClN2O. Mole weight: 232.67.
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