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| Product | Description | |
|---|---|---|
| Melanin | Melanin is a unique pigment with myriad functions. It is multifunctional, providing defense against environmental stresses such as ultraviolet (UV) light, oxidizing agents and ionizing radiation. Uses: Scientific research. Group: Natural products. CAS No. 8049-97-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-113485. |  |
| Melanin-concentratinghormone(human)(9ci) | Heterocyclic Organic Compound. Alternative Names: Melanin concentrating hormone,human,mouse,rat; 128315-56-0; Melanin Concentrating Hormone,human,mouse. CAS No. 128315-56-0. Molecular formula: C105H160N30O26S4. Mole weight: 2386.84. Appearance: White powder. Purity: 0.96. IUPACName: Melanin Concentrating Hormone rat. Catalog: ACM128315560. |  |
| Melanin Concentrating Hormone, salmon | Melanin Concentrating Hormone (MCH), salmon is a 19-amino acid neuropeptide, originally found in the pituitary gland of teleost fish, that regulates food intake, energy balance, sleep status and the cardiovascular system. MCH is a ligand for orphan G protein coupled receptor (SLC-1/GPR24) and MCHR2. Synonyms: MCH (salmon); Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val (Disulfide bridge: Cys5-Cys14); L-alpha-aspartyl-L-threonyl-L-methionyl-L-arginyl-L-cysteinyl-L-methionyl-L-valyl-glycyl-L-arginyl-L-valyl-L-tyrosyl-L-arginyl-L-prolyl-L-cysteinyl-L-tryptophyl-L-alpha-glutamyl-L-valine (5->14)-disulfide. Grades: ≥90%. CAS No. 87218-84-6. Molecular formula: C89H139N27O24S4. Mole weight: 2099.48. |  |
| Melanin Concentrating Hormone, salmon acetate | Melanin Concentrating Hormone, salmon acetate is a 19-amino acid neuropeptide, originally found in the pituitary gland of teleost fish, that regulates food intake, energy balance, sleep status and the cardiovascular system. MCH is a ligand for orphan G protein-coupled receptor (SLC-1/GPR24) and MCHR2. Synonyms: MCH (salmon) acetate; L-Valine, L-α-aspartyl-L-threonyl-L-methionyl-L-arginyl-L-cysteinyl-L-methionyl-L-valylglycyl-L-arginyl-L-valyl-L-tyrosyl-L-arginyl-L-prolyl-L-cysteinyl-L-tryptophyl-L-α-glutamyl-, cyclic (5?14)-disulfide acetate; Melanin-concentrating hormone (Oncorhynchus keta) acetate; Melanin-concentrating hormone (Carassius auratus) acetate; Melanin-concentrating hormone (Oncorhynchus keta reduced), cyclic (5?14)-disulfide acetate; Salmon melanin-concentrating hormone acetate; H-Asp-Thr-Met-Arg-Cys-Met-Val-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Glu-Val-OH.CH3CO2H (Disulfide bridge: Cys5-Cys14); L-alpha-aspartyl-L-threonyl-L-methionyl-L-arginyl-L-cysteinyl-L-methionyl-L-valyl-glycyl-L-arginyl-L-valyl-L-tyrosyl-L-arginyl-L-prolyl-L-cysteinyl-L-tryptophyl-L-alpha-glutamyl-L-valine (5->14)-disulfide. Grades: ≥95%. Molecular formula: C91H143N27O26S4. Mole weight: 2159.55. | |
| 15-Methylhexadeca Sphinganine | The major sphinganine from the ceramides phospholipids of Bacteroides melaninogenicus as arachidonate cascade inhibitor and blood platelet aggregation inhibitor. Group: Biochemicals. Alternative Names: [R-(R*,S*)]-2-Amino-15-methyl-1,3-hexadecanediol; D-erythro- 2-Amino-15-methyl-1,3-hexadecanediol; D-erythro-C17-iso-Sphinganine. Grades: Highly Purified. CAS No. 26048-10-2. Pack Sizes: 1mg. US Biological Life Sciences. |  Worldwide |
| 2-(4-Bromophenyl)propan-2-amine | 2-(4-Bromophenyl)propan-2-amine acts as a reagent for the synthesis of biaryl diamides as potent melanin concentrating hormone receptor 1 antagonist. Group: Biochemicals. Grades: Highly Purified. CAS No. 17797-12-5. Pack Sizes: 250mg, 1g. Molecular Formula: C9H12BrN, Molecular Weight: 214.1. US Biological Life Sciences. | Worldwide |
| (2E) -2- [ (2-Methoxyphenyl ) methy l ene ] hydrazinecar bothioamide | (2E) -2- [ (2-Methoxyphenyl ) methy l ene ] hydrazinecar bothioamide is used in skin whitening compounds, as it inhibits the generation of melanins. Group: Biochemicals. Grades: Highly Purified. CAS No. 497161-86-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H11N3OS, Molecular Weight: 209.27. US Biological Life Sciences. | Worldwide |
| (2E) -2- [ (4-Ethyl phenyl ) methyl ene ] hydrazinecarb othioamide | (2E) -2- [ (4-Ethyl phenyl ) methyl ene ] hydrazinecarb othioamide is used in skin whitening compounds, as it inhibits the generation of melanins. Group: Biochemicals. Grades: Highly Purified. CAS No. 1334179-95-1. Pack Sizes: 50mg, 100mg. Molecular Formula: C10H13N3S, Molecular Weight: 251.55. US Biological Life Sciences. | Worldwide |
| (2E) -2- [ (4-methyl phenyl ) met hyl ene ] hydrazinec arbothioamide | (2E) -2- [ (4-methyl phenyl ) met hyl ene ] hydrazinec arbothioamide is used in skin whitening compounds, as it inhibits the generation of melanins. Group: Biochemicals. Grades: Highly Purified. CAS No. 1321617-35-9. Pack Sizes: 50mg, 100mg. Molecular Formula: C9H11N3S, Molecular Weight: 193.27. US Biological Life Sciences. | Worldwide |
| 2-Ethoxybenzamide | 2-Ethoxybenzamide (Ethenzamide) is a nonsteroidal anti-inflammatory agent that shows analgesic and antipyretic effects [1]. 2-Ethoxybenzamide induces melanin synthesis via cAMP response element-binding protein (CREB) phosphorylation [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Ethenzamide. CAS No. 938-73-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-B1428. | |
| 2-Methyl-6-nitroquinoline | 2-Methyl-6-nitroquinoline is a reagent that is used as a potent, selective, and orally efficacious antagonists of melanin-concentrating hormone receptor 1. Group: Biochemicals. Grades: Highly Purified. CAS No. 613-30-9. Pack Sizes: 5g, 50g. Molecular Formula: C10H8N2O2, Molecular Weight: 188.18. US Biological Life Sciences. | Worldwide |
| 2-O-a-D-Glucopyranosyl-L-ascorbic acid | Antioxidant, inhibit melanin. Synonyms: Ascorbic acid 2-glucoside Ascorbyl glucoside. Grades: 98%. CAS No. 129499-78-1. Molecular formula: C12H18O11. Mole weight: 338.26. | |
| 3-? (Isopropylamino) ?propan-?1-?ol | 3-? (Isopropylamino) ?propan-?1-?ol is a reagent used in the treatment of obesity and CNS disorders through antagonism of melanin concentrating hormone receptor 1 (MCHR1). Group: Biochemicals. Grades: Highly Purified. CAS No. 33918-15-9. Pack Sizes: 1g, 5g. Molecular Formula: C6H15NO, Molecular Weight: 117.19. US Biological Life Sciences. | Worldwide |
| 4-(1-Phenylethyl)resorcinol | 4-(1-Phenylethyl)resorcinol is a skin lightening agent used in cosmetics. It works by inhibiting the production of melanin, the pigment that gives skin its color. This helps reduce the appearance of dark spots, hyperpigmentation and uneven skin tone. 4-(1-Phenylethyl)resorcinol is considered safe for cosmetic use and is approved for use in several countries. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 85-27-8. Pack Sizes: 1 g; 5 g. Product ID: HY-125809. | |
| 4,6-Dibenzoylresorcinol | 4,6-Dibenzoylresorcinol, a chemical compound ubiquitous in the biomedical sector, serves as a fundamental skin-lightening agent and its efficacy against hyperpigmentation disorders, including melasma, has been established. By inhibiting melanin production, 4,6-dibenzoylresorcinol considerably reduces skin pigmentation, resulting in white-toned skin. It also features potent antioxidant and antibacterial properties which grant it further potential to combat various dermatological conditions. Synonyms: (5-benzoyl-2,4-dihydroxyphenyl)-phenylmethanone; (4,6-Dihydroxy-1,3-phenylene)bis(phenylmethanone). CAS No. 3088-15-1. Molecular formula: C20H14O4. Mole weight: 318.32. | |
| 5,6-Dihydroxyindole | 5,6-Dihydroxyindole, a melanin precursor, has a broad-spectrum antibacterial , antifungal , antiviral , antiparasitic activity. 5,6-Dihydroxyindole has cytotoxic effects and is strongly toxic against various pathogens [1]. Uses: Scientific research. Group: Natural products. CAS No. 3131-52-0. Pack Sizes: 100 mg; 1 g; 5 g. Product ID: HY-W018025. | |
| 5,6-Dihydroxyindole-2-carboxylic Acid | 5,6-Dihydroxyindole-2-carboxylic Acid is the indole analogue of DOPA. 5,6-Dihydroxyindole-2-carboxylic Acid is a precursor to melanin as well as potential as HIV-1 integrase inhibitors. Group: Biochemicals. Alternative Names: 2-Carboxy-5,6-dihydroxyindole; 5,6-Dihydroxy-1H-indole-2-carboxylic Acid; 5,6-Dihydroxy-2-carboxyindole. Grades: Highly Purified. CAS No. 4790-8-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| 5,6-O-Isopropylidene-L-ascorbic acid | 5,6-O-Isopropylidene-L-ascorbic acid, a highly regarded biomedicine, holds immense potential in addressing an array of dermatological concerns such as skin hyperpigmentation, photoaging, and oxidative stress-related disorders. Esteemed for its remarkable stability and exceptional skin permeation, this compound unveils its efficacy as a pivotal constituent within cutting-edge skincare formulations. By virtue of its profound antioxidative attributes, it orchestrates a substantial reduction in melanin synthesis while concurrently fostering collagen synthesis. Synonyms: L-Ascorbic acid acetonide. CAS No. 15042-01-0. Molecular formula: C9H12O6. Mole weight: 216.19. | |
| Acetyl Hexapeptide-1 | Acetyl Hexapeptide-1, also known as Melitane, is a biomimetic peptide antagonist of the α-MSH (α-Melanocyte-Stimulating Hormone). It stimulates tyrosinase activity, melanin synthesis and melanocyte dendricity, and protects DNA damage caused by UV exposure. Synonyms: Melitane. Grades: 98%. CAS No. 448944-47-6. Molecular formula: C43H59N13O7. Mole weight: 870. | |
| Acetyl Tyrosine & Riboflavin | Unique preparation rich in tyrosine and riboflavin that stimulates the biochemical reactions of melanin formation in the skin. It helps to obtain a quicker, more intense and long lasting suntan in a clear and visible way. Uses: Tanning products, after-tanning lotions. Group: Skin actives. CAS No. 7732-18-5/56-81-5/537-55-3/83-88-5. Appearance: Clear, colorless to slighly yellow liquid, no odor. Catalog: CI-SC-0775. | |
| [Ala17]-MCH | [Ala17]-MCH is a melanin-concentrating hormone receptor agonist with EC50 values of 17 and 54 nM at MCH1 and MCH2 receptors. Grades: ≥95% by HPLC. CAS No. 359784-84-2. Molecular formula: C97H155N29O26S4. Mole weight: 2271.71. | |
| Aloe Vera extract | One study performed on animals demonstrated that the leaf extract of aloe vera and its active ingredient aloin promoted significant, dose-dependent melanin aggregation, resulting in skin-lightening through and renergic receptor stimulation.56 Aloe vera is incorporated into numerous cosmeceutical formulations. Synonyms: Aloe Extract. Grades: 0.99. | |
| alpha-Arbutin | Hydroquinone derivative isolated from the leaves of the bearberry shrub, cranberry, blueberry, some mushrooms, and most types of pears. It inhibits tyrosinase and thus prevents the formation of melanin. Arbutin is therefore used as a skin-lightening agent. Categories: alpha Arbutin. |  United States and all of its trading partners.. |
| Alpha-arbutin | Alpha-arbutin. Synonyms: 4-Hydroxyphenyl α-D-glucopyranoside, Hydroquinone O-α-D-glucopyranoside. CAS No. 84380-01-8. Pack Sizes: 1 kg. Product ID: CDC10-0374. Molecular formula: C12H16O7. Category: Cosmetic Surfactants. Product Keywords: Cosmetic Ingredients; Cosmetic Surfactants; Alpha-arbutin; CDC10-0374; 84380-01-8; C12H16O7; 4-Hydroxyphenyl α-D-glucopyranoside, Hydroquinone O-α-D-glucopyranoside; MFCD09838262; 84380-01-8. Grade: Analytical standard. Purity: 0.995. Color: White. Physical State: Powder. Solubility: DMSO (Slightly), Methanol (Slightly). Quality Level: 100. Storage: 2-8°C. Application: Personal care. Boiling Point: 561.6±50.0 °C(Predicted). Melting Point: 195-196°C. Density: 1.556±0.06 g/cm3(Predicted). Product Description: α-Arbutin is a glycosylated hydroquinone and an anomer of naturally occurring arbutin. It is a potent inhibitor of tyrosinase, a vital enzyme involved in epidermal melanin biosynthesis. α-Arbutin finds extensive application as a powerful skin-lightening agent in cosmetic industries. |  |
| Amphistin | It is produced by the strain of Actinornycete KP-3052. It has weak antibacterial activity. Inhibition of melanoma cell B16 production of melanin without affecting the growth of the cell, IC50 is 55 μmol/L. Synonyms: amphistin. Molecular formula: C13H21N5O6. Mole weight: 343.33. | |
| Arbutin | Arbutin is a natural active substance derived from green plants. It combines the "green plant, safe and reliable" and "high-efficiency discoloration" into a skin decolorizing component, which can quickly penetrate into the skin without affecting cell proliferation. At the same time, it can effectively inhibit the activity of tyrosinase in the skin, block the formation of melanin, and directly combine with tyrosinase to accelerate the decompositio;n and excretion of melanin, thereby reducing skin pigmentation, eliminating pigmentation and Freckles, and do not produce toxic, irritating, sensitizing and other side effects on melanocytes, as well as bactericidal and anti-inflammatory effects. Group: Material of cosmetics. Alternative Names: 4-Hydroxyphenyl-beta-D-glucopyranosid. CAS No. 497-76-7. Molecular formula: C12H16O7. Mole weight: 272.25. Appearance: Solid. Purity: 0.98. IUPACName: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(4-hydroxyphenoxy)oxane-3,4,5-triol. Canonical SMILES: C1=CC(=CC=C1O)OC2C(C(C(C(O2)CO)O)O)O. Density: 1.3582 g/cm³. ECNumber: 207-850-3. Catalog: ACM497767. | |
| Arbutin | Arbutin. Synonyms: Hydroquinone-Beta-D-glucopyranoside. CAS No. 497-76-7. Product ID: CDC10-0032. Molecular formula: C12H16O7. Category: Antioxidant Cosmetic Chemicals. Product Keywords: Cosmetic Ingredients; Antioxidant Cosmetic Chemicals; Arbutin; CDC10-0032; 497-76-7; C12H16O7; Hydroquinone-Beta-D-glucopyranoside; 207-850-3; MFCD00016915; 497-76-7. Purity: ≥98%. Color: White. EC Number: 207-850-3. Physical State: Powder. Solubility: H2O: 50 mg/mL hot, clear. Quality Level: 200. Storage: Inert atmosphere,Room Temperature. Application: Arbutin, a glycosylated hydroquinone, is used in studies on melanin biosynthesis and as an inhibitor to identify, differentiate and characterize tyrosinase(s). Boiling Point: 375.31°C (rough estimate). Melting Point: 195 °C. Product Description: Arbutin is a derivative of hydroquinone used in skin-whitening ingredients. It is reported to inhibit the activity of tyrosinase, which is a key enzyme for melanin biosynthesis. This acts to effectively prevent the anomalous increase of melanin which is blamed for age or sun spots and freckles. | |
| Ascorbyl Glucoside | Ascorbyl glucoside is a form of vitamin C that is used in skincare and cosmetic products. It is a water-soluble derivative of vitamin C that is more stable and less irritating than pure vitamin C. It is a potent antioxidant that protects the skin from damaging free radicals and helps to brighten the complexion by inhibiting melanin production. Ascorbyl glucoside also promotes collagen synthesis, which can help to improve the texture and elasticity of the skin, and has anti-inflammatory properties that can help to soothe and calm irritated skin. Overall, ascorbyl glucoside is a popular ingredient in anti-aging, brightening, and protective skincare products. Uses: 1. ascorbyl glucoside is a stable form of vitamin c that is used in skincare products. 2. it helps in brightening the skin and reducing dark spots and hyperpigmentation. 3. it is known for its antioxidant properties that protect the skin from harmful free radicals. 4. ascorbyl glucoside also helps in collagen synthesis, which improves skin elasticity and reduces fine lines and wrinkles. 5. it is s. Group: Material of cosmetics. Alternative Names: Ascorbic acid 2-O-glucoside;2-O-alpha-D-Glucopyranosyl-L-ascorbic acid;L-Ascorbic acid 2-O-alpha-glucoside. CAS No. 129499-78-1. Molecular formula: C12H18O11. Mole weight: 338.26. Appearance: white to off-white powder or crystalline powder. Density: 1.83 g/cm³. Catalog: ACM129499781. | |
| Ascorbyl tetraisopalmitate | Ascorbyl Tetraisopalmitate, also known as Ascorbyl Tetra-2 Hexyldecanoate, is a newly developed esterified derivative of Vitamin C with the highest stability of all Vitamin C derivatives. It can be absorbed transdermally and then effectively converted into vitamin C; it can inhibit the synthesis of melanin and remove the melanin present. Accordingly, it activates the collagen tissue directly at the base of the skin, accelerates collagen production and prevents skin aging. It also plays a role as an anti-inflammatory agent and Antioxidants. Uses: Cosmetic raw materials. Synonyms: tetrahexyldecylascorbate; L-Ascorbic acid, tetrakis(2-hexyldecanoate); L-Ascorbic acid,2,3,5,6-tetrakis(2-hexyldecanoate). Grades: > 95%. CAS No. 183476-82-6. Molecular formula: C70H128O10. Mole weight: 1129.79. | |
| [Asp371]-Tyrosinase (369-377), human | It is derived from tyrosinase, a peptide fragment that controls melanin production and has been used to develop tumor-targeted vaccines with mixed efficacy. Synonyms: Tyrosinase Fragment 369-377 human; CMM8; OCA1A; OCAIA; SHEP3; TYR; Tyr-Met-Asp-Gly-Thr-Met-Ser-Gln-Val; L-tyrosyl-L-methionyl-L-alpha-aspartyl-glycyl-L-threonyl-L-methionyl-L-seryl-L-glutaminyl-L-valine. Grades: ≥95%. CAS No. 168650-46-2. Molecular formula: C42H66N10O16S2. Mole weight: 1031.16. | |
| ATC0175 | ATC0175 is a potent, selective and orally active melanin-concentrating hormone 1 recepter antagonist with IC 50 s of 13.5, >10000 nM for MCH1R, MCH2R, respectively. ATC0175 shows antidepressant effects and anxiolytic effects in animal models. ATC0175 has the potential for the research of depression and/or anxiety disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 510733-97-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107624. | |
| AZD1979 | This active molecular is a MCHr1 (melanin concentrating hormone receptor 1) antagonist originated by AstraZeneca. AZD1979 has excellent DMPK properties and gave good effects on weight loss in animal model. In Jul 2014, AstraZeneca terminated a phase I trial in Obesity in healthy volunteers in USA after stopping criteria were reached. Uses: Obesity. Synonyms: AZD1979; AZD-1979; AZD 1979. (3-(4-((2-oxa-6-azaspiro[3.3]heptan-6-yl)methyl)phenoxy)azetidin-1-yl)(5-(4-methoxyphenyl)-1,3,4-oxadiazol-2-yl)methanone. Grades: 98%. CAS No. 1254035-84-1. Molecular formula: C25H26N4O5. Mole weight: 462.51. | |
| beta-Arbutin | Hydroquinone derivative isolated from the leaves of the bearberry shrub, cranberry, blueberry, some mushrooms, and most types of pears. It inhibits tyrosinase and thus prevents the formation of melanin. Arbutin is therefore used as a skin-lightening agent. Categories: beta Arbutin. | United States and all of its trading partners.. |
| β-Tocopherol | β-Tocopherol is an analogue of vitamin E, exhibits antioxidant properties. β-Tocopherol can inhibit tyrosinase activity and melanin synthesis. β-Tocopherol also can prevent the inhibition of cell growth and of PKC activity caused by d-alpha-tocopherol [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 16698-35-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-133680. | |
| Danshensu | Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material. Synonyms: Benzenepropanoic acid, α,3,4-trihydroxy-, (αR)-; (αR)-α,3,4-Trihydroxybenzenepropanoic acid; Benzenepropanoic acid, α,3,4-trihydroxy-, (R)-; (R)-(+)-3-(3,4-Dihydroxyphenyl)lactic acid; (R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropionic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; D-(+)-β-(3,4-Dihydroxyphenyl)lactic acid; Dan Shen Su; Dan shen suan A; DS 182; Salianic acid A; Salvianic acid A; Tanshinol. Grades: >98%. CAS No. 76822-21-4. Molecular formula: C9H10O5. Mole weight: 198.17. | |
| Decapeptide-12 | Decapeptide-12 reversibly binds to tyrosinase, an enzyme found in a number of different pigment-producing cells. It prevents tyrosinase from catalyzing the oxidation of phenols, the first step in melanin production. Synonyms: L-Tyrosyl-L-arginyl-L-seryl-L-arginyl-L-lysyl-L-tyrosyl-L-seryl-L-seryl-L-tryptophyl-L-tyrosine. Grades: 98%. CAS No. 137665-91-9. Molecular formula: C65H90N18O17. Mole weight: 1395.5. | |
| Dehydroanonaine | Dehydroanonaine is a dietary supplement that is used for the treatment of pain. It inhibits the activity of creatine kinase, which is an enzyme that breaks down adenosine triphosphate (ATP) to produce energy. Dehydroanonaine also inhibits acetate extract from fatty acids and has been shown to have an inhibitory effect on tyrosinase, an enzyme involved in the production of melanin. The effective dose for dehydroanonaine is not known. Dehydroanonaine can be used cosmetically by increasing the skin's elasticity and reducing wrinkles and age spots. Group: Other alkaloids. CAS No. 41679-82-7. Molecular formula: C17H13NO2. Mole weight: 263.29 g/mol. Canonical SMILES: C1CNC2= CC3= CC= CC= C3C4= C2C1= CC5= C4OCO5. Catalog: ACM41679827. | |
| D-Tyrosine | D-Tyrosine is the D-isomer of tyrosine. D-Tyrosine negatively regulates melanin synthesis by inhibiting tyrosinase activity. D-Tyrosine inhibits biofilm formation and trigger the self-dispersal of biofilms without suppressing bacterial growth [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 556-02-5. Pack Sizes: 500 mg; 1 g; 5 g. Product ID: HY-Y0444. | |
| Ethyl linolenate | Ethyl linolenate is a fatty acid ethyl ester (FAEE). Ethyl linolenate plays an active role in inhibition of the cellular production on melanin with an IC 50 of 70 μM. Anti-melanogenesis Effects [1]. Uses: Scientific research. Group: Natural products. CAS No. 1191-41-9. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg; 500 mg. Product ID: HY-N2073. | |
| Glycolic acid | Glycolic acid is an inhibitor of tyrosinase , suppressing melanin formation and lead to a lightening of skin colour. Uses: Scientific research. Group: Natural products. Alternative Names: Hydroxyethanoic acid. CAS No. 79-14-1. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-W015967. | |
| Gnetol | Gnetol is a phenolic compound isolated from the root of Gnetum montanum. Gnetol potently inhibits COX-1 (IC50 of 0.78 μM) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4.5 μM for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration-dependent α-Amylase, α-glucosidase, and adipogenesis activities. Group: Inhibitors. Alternative Names: 2-[(1E)-2-(3,5-Dihydroxyphenyl)ethenyl]-1,3-benzenediol;Gnetol. CAS No. 86361-55-9. Molecular formula: C14H12O4. Mole weight: 244.2. Appearance: Powder. Purity: 0.98. IUPACName: 2-[(E)-2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,3-diol. Canonical SMILES: C1=CC (=C (C (=C1)O)C=CC2=CC (=CC (=C2)O)O)O. Catalog: ACM86361559. | |
| GW 803430 | GW 803430 is a potent and selective melanin-concentrating hormone receptor 1 (MCH1) antagonist (IC50 = 9.3 nM). GW 803430 exhibits antiobesity and antidepressant-like effects in rats and mice. Synonyms: GW-803430; GW 803430; GW803430. 6-(4-Chlorophenyl)-3-[3-methoxy-4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-thieno[3,2-d]pyrimidin-4(3H)-one. Grades: ≥99% by HPLC. CAS No. 515141-51-2. Molecular formula: C25H24ClN3O3S. Mole weight: 481.99. | |
| Ioflubenzamide I-131 | Ioflubenzamide I-131 is an iodine 131-radiolabeled small-molecule benzamide compound with potential antineoplastic activity. The benzamide moiety of ioflubenzamide I-131 binds to melanin, selectively delivering a cyotoxic dose of gamma and beta radiation to melanin-expressing tumor cells. Melanin pigments, polymer derivatives of the amino acid tyrosine, are over-expressed in approximately 40% of melanomas. Synonyms: BA-100; MIP-1145; 131-I-MIP-1145. CAS No. 864462-68-0. Molecular formula: C21H25F131IN3O3. Mole weight: 517.35. | |
| Kojic acid | Kojic acid is a substance produced by Aspergillus oryzae that is orally effective and can also be absorbed transdermally. Kojic acid exhibits various biological activities, including anti-aging, anti-nematode, antimicrobial, antioxidant, and anti-inflammatory effects. Kojic acid is a Tyrosinase inhibitor with an Mushroom Tyrosinase IC 50 of 182.7 μM. Kojic acid prevents melanin production by capturing copper ions that bind to the tyrosinase active site, thus inhibiting its activation. Kojic acid also suppresses the NF-κB and p21 signaling pathways in human keratinocytes. Kojic acid derivatives have anticancer activity [1] [2] [3] [4] [5] [6] [7] [8]. Uses: Scientific research. Group: Natural products. CAS No. 501-30-4. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W050154. | |
| Kojic Acid | It is produced from the Aspergillus parasiticus. Kojic Acid has anti-leptospira effect with MIC of 1-10 μg/mL. It is also a tyrosinase inhibitor, which acts as a chelating agent that inhibits the production of melanin and should help chloasma in vitro. Synonyms: 5-Hydroxy-2-(hydroxymethyl)-4-pyrone; 4H-PYRAN-4-ONE, 5-HYDROXY-2-(HYDROXYMETHYL)-; 2-Hydroxymethyl-5-hydroxy-gamma-pyrone; NSC 1942. Grades: ≥99%. CAS No. 501-30-4. Molecular formula: C6H6O4. Mole weight: 142.11. | |
| Kojipentaose | Kojipentaose is an innovative compound product utilized in the research of hyperpigmentation and skin disorders. Derived from Kojic acid, this compound inhibits tyrosinase activity, reducing melanin production. CAS No. 112289-20-0. Molecular formula: C30H52O26. Mole weight: 828.72. | |
| Lipoteichoic acid | Lipoteichoic acid is an orally effect anti-inflammatory and antitumor agent. Lipoteichoic acid is a crucial immune molecule in Gram-positive bacteria that activates the complement system by inducing C3 and inhibiting CD55. Lipoteichoic acid regulates macrophage autophagy through the PI3K/Akt/mTOR pathway. Lipoteichoic acid induces lung damage in mice. Lipoteichoic acid inhibits the production of melanin [1] [2] [3] [4] [5] [6] [7]. Uses: Scientific research. Group: Natural products. CAS No. 56411-57-5. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N9481. | |
| L-phenylalanine | L-Phenylalanine is an essential amino acid that is important for the biosynthesis of other amino acids including melanin, dopamine, noradrenalin and thyroxine. Protein supplement in health care products. Uses: Ingredient of health care products. Synonyms: Phenylalanine; (S)-2-Amino-3-phenylpropanoic acid; 3-Phenyl-L-alanine; (S)-Phenylalanine; H-Phe-OH; Alanine, phenyl-, L-; (-)-Phenylalanine; (S)-(-)-Phenylalanine; (S)-Phenylalanine; (S)-α-Amino-β-phenylpropionic acid; (S)-α-Aminobenzenepropanoic acid; (S)-α-Aminohydrocinnamic acid; 3-Phenylalanine; L-(-)-Phenylalanine; L-Alanine, 3-phenyl-; Antibiotic FN 1636; Benzenepropanoic acid, α-amino-, (S)-; NSC 79477; Phenyl-α-alanine; Phenylalanine; β-Phenyl-L-alanine; β-Phenyl-α-alanine; Aspartame EP Impurity C. Grades: 98%. CAS No. 63-91-2. Molecular formula: C9H11NO2. Mole weight: 165.20. | |
| L-Tyrosine | L-Tyrosine is an important nutrient essential amino acid, which plays an important role in human and animal metabolism, growth and development, and is widely used in food, feed, medicine and chemical industry. It is often used as raw material for preparation of polypeptide hormones, antibiotics, L-dopa, melanin, p-hydroxycinnamic acid, p-hydroxystyrene and other pharmaceutical and chemical products. CAS No. 60-18-4. Product ID: PAP-0022. Molecular formula: C9H11NO3. Category: Amino acid. Product Keywords: Amino Acid Series; L-Tyrosine; PAP-0022; Amino acid; C9H11NO3; 60-18-4. Grade: Pharmaceutical Grade. Color: White to Pale-brown. EC Number: 200-460-4. Physical State: powder. Solubility: 1 M HCl: 25 mg/mL. Storage: Store below +30°C. Boiling Point: 314.29°C (rough estimate). Melting Point: >300 °C (dec.) (lit.). Density: 1.34. | |
| MCH (human, mouse, rat) | MCH is an endogenous melanin-concentration hormone receptor agonist with IC50 values of 0.3 and 1.5 nM at MCH1 and MCH2 receptors respectively. It can increase food intake in vivo. Synonyms: Melanin concentrating hormone, human, mouse, rat; Asp-Phe-Asp-Met-Leu-Arg-Cys-Met-Leu-Gly-Arg-Val-Tyr-Arg-Pro-Cys-Trp-Gln-Val. Grades: ≥95% by HPLC. CAS No. 128315-56-0. Molecular formula: C105H160N30O26S4. Mole weight: 2386.84. | |
| MCHr1 antagonist 1 | A selective antagonist of melanin concentrating hormone-1 (MCH1) receptor. Synonyms: 5-Pyrimidinecarboxylic acid, 6-(3,4-difluorophenyl)-1,2,3,6-tetrahydro-4-(methoxymethyl)-2-oxo-1-[[[3-[4-(2-pyridinyl)-1-piperidinyl]propyl]amino]carbonyl]-, methyl ester. CAS No. 391610-37-0. Molecular formula: C28H33F2N5O5. Mole weight: 557.59. | |
| Melanocin A | It is produced by the strain of Eupenicillium shearii F80965. It is a Melanin biosynthesis inhibitor. It inhibits the biosynthesis of melanin and tyrosinase (IC50 is 9.0 nmol/L, MIC is 0.9 μmol/L). It also has antioxidant effect. Molecular formula: C18H14N2O5. Mole weight: 338.31. | |
| Melanocin B | It is produced by the strain of Eupenicillium shearii F80965. It does not inhibit the biosynthesis of melanin and tyrosinase. It has antioxidant effect. Molecular formula: C17H15NO6. Mole weight: 329.30. | |
| Melanocin C | It is produced by the strain of Eupenicillium shearii F80965. It does not inhibit the biosynthesis of melanin and tyrosinase. It has antioxidant effect. Molecular formula: C18H14N2O6. Mole weight: 354.31. | |
| Melanoxazal | It is produced by the strain of Trichoderma sp. ATF-451. It is a Melanin biosynthesis inhibitor. It can inhibit melanin formation in the silkworm larva hemolymph (IC50 is 30.1 μg/mL), and also has stronger inhibitory effect against mushroom tyrosinase (IC50 is 4.2 μg/mL), but it has no antimicrobial effect. Molecular formula: C8H9NO3. Mole weight: 167.16. | |
| Methyl myristate | Methyl myristate is a saturated fatty acid methyl ester obtained from the esterification of myristic acid. Methyl myristate shows a high melanin induction in B16F10 melanoma [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Tetradecanoic acid methyl ester. CAS No. 124-10-7. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W004288. | |
| MR304A | MR304A is extracted from Trichoderma harzianum. It can inhibit the formation of melanin by Mushroom tyrosinase, Streptomyces bikiniensis and B16 melanoma cells, with IC50 (μg/L) of 7.5, 2.5 and 1.0, respectively. Synonyms: MR-304A; MR 304A. Molecular formula: C8H11NO4. Mole weight: 185.18. | |
| MR-566A | It is produced by the strain of Trichoderma harzianus KCTC 0114BP. MR-566A inhibited mushroom enzyminase and melanin biosynthesis in B16 melanoma cells with IC50 (μmol/L) of 1.72 and 0.1, respectively. Synonyms: SCHEMBL20203773. Molecular formula: C8H10ClNO3. Mole weight: 203.62. | |
| MR-566B | It is produced by the strain of Trichoderma harzianus KCTC 0114BP. MR-566B inhibited mushroom enzyminase and melanin biosynthesis in B16 melanoma cells with IC50 (μmol/L) of 47 and 2.2, respectively. Synonyms: SCHEMBL20203767. Molecular formula: C8H11NO4. Mole weight: 185.18. | |
| Neuropeptide EI, rat | Neuropeptide EI, rat exhibits functional melanin-concentrating hormone (MCH) antagonist and melanocyte-stimulating hormone (MSH) agonist activities under different behavioral patterns. Synonyms: Neuropeptide EI (human, mouse, rat); H-Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-NH2; L-alpha-glutamyl-L-isoleucyl-glycyl-L-alpha-aspartyl-L-alpha-glutamyl-L-alpha-glutamyl-L-asparagyl-L-seryl-L-alanyl-L-lysyl-L-phenylalanyl-L-prolyl-L-isoleucinamide; NEI (rat). Grades: ≥95%. CAS No. 125934-45-4. Molecular formula: C63H98N16O23. Mole weight: 1447.55. | |
| Neuropeptide EI, rat acetate | Neuropeptide EI, rat acetate exhibits functional melanin-concentrating hormone (MCH) antagonist and melanocyte-stimulating hormone (MSH) agonist activities under different behavioral patterns. Synonyms: H-Glu-Ile-Gly-Asp-Glu-Glu-Asn-Ser-Ala-Lys-Phe-Pro-Ile-NH2.CH3CO2H; L-α-Glutamyl-L-isoleucylglycyl-L-α-aspartyl-L-α-glutamyl-L-α-glutamyl-L-asparaginyl-L-seryl-L-alanyl-L-lysyl-L-phenylalanyl-L-prolyl-L-isoleucinamide acetate; Pro-MCH (AA 131-143) acetate; Pro-MCH [131-143] acetate. Grades: ≥95%. Molecular formula: C65H102N16O25. Mole weight: 1507.60. | |
| Nonapeptide-1 | Nonapeptide-1 is a skin lightening peptide that prevents melanin synthesis and unwanted pigmentation. It is used as an additive in whitening or spot corrective products. Uses: Skin lightening additive. Synonyms: Melanostatine; Oxytocin Intermediate-nine peptide. CAS No. 158563-45-2. Molecular formula: C61H87N15O9S. Mole weight: 1206.523. | |
| Nonapeptide-1 | Nonapeptide-1 (Melanostatine-5), a peptide hormone, is a selective antagonist of MC1R ( K i : 40 nM). Nonapeptide-1 is a competitive α-MSH antagonist that potently inhibits intracellular cAMP and melanosome dispersion induced by α-MSH in melanocytes ( IC 50 : 2.5 nM and 11 nM, respectively). Nonapeptide-1 inhibits melanin synthesis, and can be used in the research of skin pigmentation and regulation of steroid production in the adrenal gland, skin cancer [1] [2] [3]. Uses: Scientific research. Group: Peptides. Alternative Names: Melanostatine-5. CAS No. 158563-45-2. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P0097. | |
| Paeonia Suffruticosa Root Extract | Paeonia Suffruticosa Root Extract is an ingredient derived from the roots of the Peony plant, which is also known as tree peony or the mudan plant. This extract is commonly used in skincare and cosmetic products due to its purported anti-inflammatory, antioxidant, and skin brightening effects. The active compounds in Paeonia Suffruticosa Root Extract include paeoniflorin, catechin, and gallic acid, which are known for their anti-inflammatory effects. These compounds are believed to help reduce redness, swelling, and irritation in the skin. Additionally, the antioxidant properties of this extract are thought to protect the skin against free radical damage, which can lead to premature aging and skin damage. In addition to its anti-inflammatory and antioxidant properties, Paeonia Suffruticosa Root Extract is also believed to have skin brightening effects. It is said to inhibit the production of melanin, which can lead to hyperpigmentation and uneven skin tone. Uses: 1. anti-inflammatory: paeonia suffruticosa root extract has anti-inflammatory properties that help in reducing inflammation and swelling. 2. antioxidant: the extract is a rich source of antioxidants that protect the skin from free radical damage. 3. skin brightening: it can help improve the complexion and make the skin look brighter. 4. anti-aging: it has anti-aging properties that can help reduce. Group: Skin actives. CAS No. 223747-88-4. Appea | |
| Papain | Papain is a proteolytic enzyme found in papaya fruit. It breaks down protein molecules into smaller peptides and amino acids, making it useful in a variety of industries such as food, cosmetic, and medical. In the cosmetic industry, papain is used in exfoliating products and as a skin lightening agent. It helps to remove dead skin cells and improve skin texture. Uses: 1. anti-inflammatory: papain has anti-inflammatory properties and has been used to reduce pain and swelling associated with injuries or conditions such as arthritis. 2. wound healing: papain has been shown to aid in the healing of wounds by breaking down dead tissue and promoting the growth of new tissue. 3. skin care: papain is a common ingredient in skin care products due to its ability to exfoliate dead skin cells and improve skin texture. it is also used in some skin lightening products as it can inhibit the production of melanin. Group: Heterocyclic organic compound. Alternative Names: arbuz; caroid; nematolyt; summetrin; tromasin; vegetablepepsin; IMMOBILIZED PAPAIN;Papain food grade. CAS No. 9001-73-4. Molecular formula: n.a. Appearance: yellowish-white to light brown powder or granule. Catalog: ACM9001734. | |
| (Phe13,Tyr19)-MCH (human, mouse, rat) | Synonyms: Melanin-concentratinghormone (human), 13-L-phenylalanine-19-L-tyrosine- (9CI); H-ASP-PHE-ASP-MET-LEU-ARG-CYS-MET-LEU-GLY-ARG-VAL-PHE-ARG-PRO-CYS-TRP-GLN-TYR-OH. CAS No. 160201-86-5. Molecular formula: C109H160N30O26S4. Mole weight: 2434.88. | |
| Polyquaternium 11 (20% in H2O) | Polyquaternium 11 is found to suppress melanin elution in shampoo thus may prevent hair from dulling after repeated shampoo use. Group: Biochemicals. Grades: Highly Purified. CAS No. 53633-54-8. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C18H35N2O3+ C2H5O4S- (C2H4)x (C3H6)y. US Biological Life Sciences. | Worldwide |
| Pro-Ser | Pro-Ser inhibits melanin synthesis in Mel-Ab cells through down-regulation of tyrosinase. Synonyms: L-Serine, N-L-prolyl-; L-prolyl-L-serine. Grades: ≥95%. CAS No. 71835-80-8. Molecular formula: C8H14N2O4. Mole weight: 202.21. | |
| Pyrrole-2,3,5-Tricarboxylic Acid | Pyrrole-2,3,5-tricarboxylic Acid is the most characteristic degrdadation product of melanins. It is an important biomarker for Melatonin metabolism. Synonyms: 1H-Pyrrole-2,3,5-tricarboxylic Acid. Grades: > 95%. CAS No. 945-32-4. Molecular formula: C7H5NO6. Mole weight: 199.12. | |
| (Rac)-Rhododendrol | (Rac)-Rhododendrol ((Rac)-Betuligenol) is an aromatic compound with pro-oxidant activity. (Rac)-Rhododendrol may be useful in the suppression of liver diseases. (Rac)-Rhododendrol can be toxic to melanocytes, leading to cell death. The metabolite of (Rac)-Rhododendrol, RD-quinone, is cytotoxic and causes enzyme inactivation and endoplasmic reticulum stress by binding to thiol proteins. (Rac)-Rhododendrol-derived melanin exhibits potent pro-oxidant activity and may cause oxidative stress [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (Rac)-Betuligenol. CAS No. 69617-84-1. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-136913. | |
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