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Parathyroid hormone (1-34) (bovine) is a parathyroid hormone (PTH) receptor agonist. It increases calcium and inorganic phosphate levels in the serum of young rats. Parathyroid hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid, which is secreted by the chief cell of the parathyroid glands as a polypeptide containing 84 amino acids. Synonyms: L-Phenylalanine, L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-;; Ala-Val-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe. CAS No. 12583-68-5. Molecular formula: C183H288N54O50S2. Mole weight: 4108.74.
Parathyroid Hormone (1-34), bovine
Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis [1]. Uses: Scientific research. Group: Peptides. CAS No. 12583-68-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1252.
Parathyroid hormone (1-34) (human)
Parathyroid hormone (1-34) (human) is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. PTH 1-34 induces bone morphogenetic protein (BMP) gene transcription. Teriparatidet is an effective anabolic (i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing. Synonyms: PTH (1-34) (Human); L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-Phenylalanine; (1-34)-Human parathormone; (1-34)-Human parathyroid hormone; 1-34-Human PTH; 1-34-Parathormone (human); H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; Parathar; Teriparatida; Forteo. Grades: ≥95%. CAS No. 52232-67-4. Molecular formula: C181H291N55O51S2. Mole weight: 4117.75.
Parathyroid hormone (1-34) (rat)
Parathyroid hormone (1-34) (rat), a synthetic, rat parathryroid hormone, is a parathyroid hormone (PTH) receptor agonist, which increases serum PTH levels and bone mass in rats. Synonyms: pTH (1-34) (rat). CAS No. 98614-76-7. Molecular formula: C180H291N55O48S2. Mole weight: 4057.74.
Parathyroid hormone (1-34) (rat)
Parathyroid hormone (1-34) (rat) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 98614-76-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P2279.
Heterocyclic Organic Compound. CAS No. 100929-95-1. Purity: 0.96. Catalog: ACM100929951.
Parathyroid hormone from bovine*parathyr oid glands
Heterocyclic Organic Compound. CAS No. 12584-96-2. Purity: 0.96. Catalog: ACM12584962.
Tissue, Membrane Protein, Human Adult Normal, Parathyroid HisTek
Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences.
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Tissue, Section, Human Adult Normal, Parathyroid (Frozen) HisTek
Tissue, Section, Human Adult Normal, Parathyroid (Frozen) HisTek. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 5 Sections. US Biological Life Sciences.
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Tissue, Section, Human Tumor, Parathyroid Tumor (Paraffin) HisTek
Paraffin tissue slides suitable for use in identifying cellular localization of RNA or protein using in situ hybridization or immunohistochemistry. Human tissue of ~5um thickness is paraffin embedded and mounted on a positively-charged glass slide. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 5 Sections. US Biological Life Sciences.
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Tissue, Total Protein, Human Adult Normal, Parathyroid HisTek
Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Tissue, Total Protein, Human Tumor, Parathyroid HisTek
Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 1mg. US Biological Life Sciences.
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A-75943
A-75943 is is a bone resorption inhibitor produced by Streptomyces sp. SANK61296. In vitro tests, it has the effect of inhibiting bone resorption with IC50 of 0.35 μmol/L. It also inhibits the bone resorption in rats with thyroid and parathyroidectomy. Synonyms: 2H-Pyran-4-acetamide, 2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)tetrahydro-6-oxo-, (2R,4S)-. Grades: >98%. CAS No. 201215-10-3. Molecular formula: C15H23NO4. Mole weight: 281.35.
Abaloparatide
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: BA 058; BIM 44058. CAS No. 247062-33-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108742.
Abaloparatide
Abaloparatide is an analogue of parathyroid hormone-related protein (PTHrP) which is used for the treatment of osteoporosis. In 28 April 2017, it was approved by FDA for the treatment of postmenopausal women with osteoporosis. Studies showed that abaloparatide could decrease the risk of new vertebral and nonvertebral fractures. Uses: The treatment of osteoporosis. Synonyms: Tymlos. Grades: 98%. CAS No. 247062-33-5. Molecular formula: C174H300N56O49. Mole weight: 3960.58.
Abaloparatide acetate
Abaloparatide acetate, an effective and selective activator of the PTHR1 signaling pathway, is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Synonyms: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2.CH3CO2H; L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide acetic acid. Grades: ≥95%. Molecular formula: C176H304N56O51. Mole weight: 4020.71.
Abaloparatide TFA
Abaloparatide TFA is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Synonyms: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2.TFA; L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide trifluoroacetic acid; BIM 44058 trifluoroacetate; Eladynos trifluoroacetate. Grades: ≥95%. Molecular formula: C176H301N56F3O51. Mole weight: 4074.61.
Heterocyclic Organic Compound. Alternative Names: PARATHYROID HORMONE-RELATED PROTEIN (1-16) (HUMAN);PARATHYROID RELATED PROTEIN (1-16);PTH-RP (1-16) (HUMAN);PTH-RELATED PEPTIDE [1-16];PTH-RELATED PROTEIN (1-16) (HUMAN, RAT);HYPERCALCEMIA OF MALIGNANCY FACTOR FRAGMENT 1-16 HUMAN;HYPERCALCEMIA OF MALIGNA. CAS No. 126391-27-3. Molecular formula: C77H128N24O25. Mole weight: 1789.99. Catalog: ACM126391273.
Asp76-pTH (39-84) (human) is a synthetic peptide widely utilized in the biomedical sector exhibiting its prowess as a potent receptor antagonist for parathyroid hormone (PTH), exerting pivotal influence over the intricate dynamics of calcium and phosphate metabolism. Synonyms: H-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-Gln-Arg-Pro-Arg-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asp-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-OH; 39-84-Parathormone (human); L-Alanyl-L-prolyl-L-leucyl-L-alanyl-L-prolyl-L-arginyl-L-α-aspartyl-L-alanylglycyl-L-seryl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-lysyl-L-α-glutamyl-L-α-aspartyl-L-asparaginyl-L-valyl-L-leucyl-L-valyl-L-α-glutamyl-L-seryl-L-histidyl-L-α-glutamyl-L-lysyl-L-seryl-L-leucylglycyl-L-α-glutamyl-L-alanyl-L-α-aspartyl-L-lysyl-L-alanyl-L-α-aspartyl-L-valyl-L-α-aspartyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-alanyl-L-lysyl-L-seryl-L-glutamine; human parathormone (39-84). Grades: ≥95% by HPLC. CAS No. 79804-72-1. Molecular formula: C211H356N66O73. Mole weight: 4985.55.
Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Synonyms: 2(1H)-Quinazolinone, 1-(1-methylethyl)-4-[4-(1-methylethyl)phenyl]-6-(2-propyn-1-yloxy)-. Grades: >98%. CAS No. 478963-79-0. Molecular formula: C23H24N2O2. Mole weight: 360.45.
Cinacalcet Impurity 17
Cinacalcet Impurity 17 is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: (R)-1-(7,8-DIHYDRONAPHTHALEN-1-YL)ETHAN-1-AMINE; 802918-45-2; (1R)-1-(7,8-dihydronaphthalen-1-yl)ethanamine; SCHEMBL13138362; Y13455. Grades: > 95%. CAS No. 802918-45-2. Molecular formula: C12H15N. Mole weight: 173.26.
Cinacalcet Impurity B (HCl salt form)
Cinacalcet Impurity B (HCl salt form) is an impurity of Cinacalcet, a medication used to treat secondary hyperparathyroidism in patients with chronic kidney disease and parathyroid carcinoma. Synonyms: (R)-(-)-N-BENZYL-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE; (R)-N-BENZYL 1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE; (R)-N-[1-(1-NAPHTHYL)ETHYL]BENZYLAMINE HYDROCHLORIDE; (R)-(-)-N-BENZYL-1-(1-NAPHTHYL)ETHYLAMI&; N-benzyl-1-(1-naphthyl)ethylamine hydrochloride. Grades: 95%. CAS No. 163831-65-0. Molecular formula: C19H20ClN. Mole weight: 297.82.
Cinacalcet Impurity E HCl
(αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine, is an impurity of Cinacalcet, which is is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels). Synonyms: (αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride. Grades: > 95%. Molecular formula: C22H26ClN. Mole weight: 339.9.
Dihydrotachysterol
Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67-96-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0245.
Dihydrotachysterol
Dihydrotachysterol is a vitamin D that can be regarded as a reduction product of vitamin D2 activated in the liver. It does not require renal hydroxylation like vitamin D2 and vitamin D3. It could stimulate intestinal calcium absorption and increases renal phosphate excretion. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids. Synonyms: HSDB 3314; Hytakerol; Parterol; Tachyrol; Dihydral; (1S,3E,4S)-4-Methyl-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-onden-4-ylidene]ethylidene]cyclohexanol; (3β,5E,7E,10α,22E)-9,10-Secoergosta-5,7,22-trien-3-ol; 24-Methyl-9,10-secocholesta-5,7,22-trien-3β-ol; Antitanil; Calcamine; DHT2; Dichystrolum; Dihidrotaquisterol; (5E,7E,22E)-(3S,10S)-9,10-seco-5,7,22-ergostatrien-3-ol. Grades: 98%. CAS No. 67-96-9. Molecular formula: C28H46O. Mole weight: 398.66.
Dihydro Tachysterol
Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D. The half synthetic Vitamin D analogue dihydrotachysterol (DHT) is widely used for hypocalcaemic hypoparathyroidism following surgical removal of parathyroids. Such treatment generally initiated by surgeons right after surgery has to be continued in clinical practice. Unfortunately, the required careful monitoring of calcium metabolism is often lacking and as demonstrated may lead to life-threatening conditions. In comparison to short acting vitamin-D derivates hypercalcaemic episodes with DHT appear to last longer and may therefore occur with higher incidence. Group: Biochemicals. Alternative Names: (1S, 3E, 4S) -4-Methyl-3- [ (2E) -2- [ (1R, 3aS, 7aR) -octahydro-7a-methyl-1- [ (1R, 2E, 4R) -1, 4, 5-trimethyl-2-hexen-1-yl] -4H-onden-4-ylidene] ethylidene] cyclohexanol; (3 β, 5E, 7E, 10α, 22E)-9, 10-Secoergosta-5, 7, 22-trien-3-ol; 24-Methyl-9,10-secocholesta-5,7,22-trien-3 β-ol; Antitanil; Calcamine; DHT2; Dichystrolum; Dihydral; Tachyrol. Grades: Highly Purified. CAS No. 67-96-9. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??O, Molecular Weight: 398.66. US Biological Life Sciences.
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DPC-AJ1951 trifluoroacetate salt
DPC-AJ1951 is a potent 14 amino acid peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). Synonyms: 2-methylalanyl-L-valyl-2-methylalanyl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-norleucyl-L-histidyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-L-tyrosinamide, trifluoroacetate salt. Grades: ≥95%. CAS No. 943519-33-3. Molecular formula: C76H127N23O19·xCF3COOH. Mole weight: 1667.
Elcatonin
Elcatonin is a calcitonin derivative used as an anti-parathyroid agent. Synonyms: Elcatonin Acetate. Grades: 98%. CAS No. 60731-46-6. Molecular formula: C148H244N42O47. Mole weight: 3363.82.
ENCALERET SULFATE
This active molecular is an CaSR (calcium-sensing receptor antagonist) under the developmet of Tobacco and Merck & Co. Calcium-sensing receptor is a member of the G protein-coupled receptor and it is very important to modulate Ca2+ homeostasis via its role in the parathyroid glands and kidneys. Encaleret was used for the treatment of osteoporosis., but was discontinued in Phase-II in Japan, India and USA in 2011. Uses: The treatment of osteoporosis. Synonyms: 4-[2-[(1R)-1-[(2R)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid;sulfuric acid;hydrate; JIT305; JIT 305; JIT-305. Grades: 98%. CAS No. 1214922-52-7. Molecular formula: C58H70Cl2F2N2O13S. Mole weight: 1144.16.
Etelcalcetide
Etelcalcetide is a calcimimetic agent used for the treatment of secondary hyperparathyroidism in patients chronic kidney disease (CKD) undergoing hemodialysis. It effects via binding to and stimulating the calcium-sensing receptor in the parathyroid gland. Uses: The treatment of secondary hyperparathyroidism. Synonyms: Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163; Parsabiv. CAS No. 1262780-97-1. Molecular formula: C38H73N21O10S2. Mole weight: 1048.26.
Etelcalcetide hydrochloride
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride. CAS No. 1334237-71-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1955A.
Etelcalcetide hydrochloride
Etelcalcetide is a calcium-sensing receptor agonist as a D-amino peptide calcimimetic for the treatment of secondary hyperparathyroidism. It can bind to and activate the CaSR (calcium-sensing receptor) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Amgen Inc. announced its submission of a New Drug Application to the FDA for etelcalcetide in Aug 2015. Synonyms: AMG-416; AMG 416; AMG416; Etelcalcetide hydrochloride; KAI-4169; KAI-4169-HCl; ONO-5163; Parsabiv; Telcalcetide; Velcalcetide; Velcalcetide hydrochloride;N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine hydrochloride;1262780-97-1 (free). Grades: >98%. CAS No. 1334237-71-6. Molecular formula: C38H74ClN21O10S2. Mole weight: 1084.72.
Evocalcet
Evocalcet (KHK7580) is an orally active calcium sensing receptor ( CaSR ) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KHK7580. CAS No. 870964-67-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17613.
FITC-abaloparatide
A Fluorescein isothiocyanate-attached Abaloparatide. Abaloparatide is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis. Grades: 95%.
Glutaurine
Glutaurine is an endogenous hormone found in the parathyroid and mammalian brain. This compound mimicks the anxiolytic drug diazepam, and has been identified as an antiepileptic. Synonyms: N-(2-Sulfoethyl)-L-glutamine; γ-Glutamyltaurine; γ-L-Glutamyltaurine; Litoralon; gamma-Glutamyltaurine; Glutaurinum. Grades: ≥95%. CAS No. 56488-60-9. Molecular formula: C7H14N2O6S. Mole weight: 254.26.
NPS-2143(SB 262470A ) is a selective potent calcium ion-sensing receptor antagonist with IC50 of 43 and 41 nM for cytoplasmic Ca2+ concentrations and parathyroid hormone secretion, respectively. Synonyms: SB-262470; NPS-2143; SB 262470; NPS 2143; SB262470; NPS2143. Grades: >98%. CAS No. 284035-33-2. Molecular formula: C24H25ClN2O2. Mole weight: 408.92.
NPS-2143 hydrochloride
NPS-2143 (SB-262,470A) is a calcilytic drug which acts as an antagonist at the Calcium-sensing receptor (CaSR), and consequently stimulates release of parathyroid hormone. Calcilytic drugs have been researched as potential treatments for osteoporosis, and as the first such compound developed, NPS-2143 is still widely used in research into the CaSR receptor as well as design of newer calcilytic agents. Synonyms: NPS2143 hydrochloride; NPS 2143 hydrochloride. Grades: >98%. CAS No. 324523-20-8. Molecular formula: C24H26Cl2N2O2. Mole weight: 445.38.
Obtusifolin
Obtusifolin, isolated from the seeds of Cassia obtusifolia , regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway [1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein [2]. Uses: Scientific research. Group: Natural products. CAS No. 477-85-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N2098.
Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Uses: Scientific research. Group: Signaling pathways. CAS No. 131918-61-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50919.
Paricalcitol Glucuronide
An impurity of Paricalcitol which is a drug used for the prevention and treatment of high levels of a certain natural substance made by the body (parathyroid hormone) in patients with long-term kidney disease. Synonyms: (1R,3R,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-Octahydro-1-[(1R,2E,4S)-5-hydroxy-1,4,5-trimethyl-2-hexen-1-yl]-7a-methyl-4H-inden-4-ylidene]ethylidene]-1,3-cyclohexanediol 25-b-D-glucuronide; 1a,25-Dihydroxy-19-nor-vitamin D2 25-b-D-glucuronide; Zemplar 25-b-D-glucuronide. Grades: > 95%. CAS No. 1260588-15-5. Molecular formula: C33H52O9. Mole weight: 592.76.
Paricalcitol Impurity 1
An impurity of Paricalcitol which is a man-made form of vitamin D to treat and prevent high levels of a certain natural substance made by the body (parathyroid hormone) in patients with long-term kidney disease. Synonyms: 22-Z-Paricalcitol; (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,Z)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol. Grades: > 95%. CAS No. 1884139-61-0. Molecular formula: C27H44O3. Mole weight: 416.65.
Paricalcitol Impurity 2
An impurity of Paricalcitol which is used to treat and prevent secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Grades: > 95%. Molecular formula: C19H34O2. Mole weight: 294.48.
Paricalcitol Sulfate
An impurity of Paricalcitol which is used to treat and prevent secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Grades: > 95%. Molecular formula: C27H44O6S. Mole weight: 496.71.
PTH (13-34) (HUMAN)
Synonyms: Parathyroid Hormone Fragment 13-34 human; Parathyroid Hormone (13-34), human; LYS-HIS-LEU-ASN-SER-MET-GLU-ARG-VAL-GLU-TRP-LEU-ARG-LYS-LYS-LEU-GLN-ASP-VAL-HIS-ASN-PHE. CAS No. 81306-64-1. Molecular formula: C125H199N39O33S. Mole weight: 2808.22.
pTH (1-34) amide (human)
pTH (1-34) amide (human) is a compound synthetic peptide hormone is acts as an agonist to the parathyroid hormone receptor. It is employed for the research of osteoporosis, hypoparathyroidism and various bone-related disorders. Synonyms: H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-NH2; Parathyroid hormone (1-34)amide; L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalaninamide; hPTH (1-34)-NH2; human parathyroid hormone (1-34) amide. Grades: 95%. CAS No. 83139-29-1. Molecular formula: C181H292N56O50S2. Mole weight: 4116.79.
pTH (28-48) (human) is an ingenious and cutting-edge compoundexpressly designed and meticulously formulated to scrutinize the profound and intricate ramifications inflicted by the coveted parathyroid hormone (PTH) upon the exceptionally intricate and multifarious research of bone metabolism and calcium homeostasis. Synonyms: Parathyroid Hormone (28-48), human; H-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-OH; L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanyl-L-valyl-L-alanyl-L-leucyl-glycyl-L-alanyl-L-prolyl-L-leucyl-L-alanyl-L-prolyl-L-arginyl-L-alpha-aspartyl-L-alanyl-glycyl-L-serine; Parathyroid Hormone Fragment 28-48 human. Grades: ≥95% by HPLC. CAS No. 83286-22-0. Molecular formula: C95H150N28O29. Mole weight: 2148.38.
pTH (3-34) (bovine)
pTH (3-34) (bovine) inhibits the stimulation of adenylate cyclase by pTH (1-34) in vitro, but has no agonist or antagonistic effect on renal phosphate transport in vivo. Synonyms: Parathyroid Hormone (3-34), bovine; H-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; bPTH (3-34); L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-phenylalanyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine. Grades: ≥95% by HPLC. CAS No. 51257-86-4. Molecular formula: C175H274N52O48S2. Mole weight: 3938.55.
pTH (53-84) (human) is a highly bioactive peptide derived from human Parathyroid Hormone (PTH), used in the biomedical industry for studying bone metabolism disorders like osteoporosis. It aids in the understanding of PTH's effect on bone formation and resorption. Synonyms: Parathyroid Hormone (53-84), human; H-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asn-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-OH; Parathyroid Hormone[Asn76]-Human Fragment 53-84; L-lysyl-L-lysyl-L-alpha-glutamyl-L-alpha-aspartyl-L-asparagyl-L-valyl-L-leucyl-L-valyl-L-alpha-glutamyl-L-seryl-L-histidyl-L-alpha-glutamyl-L-lysyl-L-seryl-L-leucyl-glycyl-L-alpha-glutamyl-L-alanyl-L-alpha-aspartyl-L-lysyl-L-alanyl-L-alpha-aspartyl-L-valyl-L-asparagyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-alanyl-L-lysyl-L-seryl-L-glutamine. Grades: ≥95% by HPLC. CAS No. 89439-30-5. Molecular formula: C149H253N43O54. Mole weight: 3510.86.
pTH (7-84) (human)
Synonyms: parathyroid hormone (7-84) (human); H-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-Gln-Arg-Pro-Arg-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asn-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-OH; Human parathyroid hormone (7-84). Grades: ≥95% by HPLC. CAS No. 406610-86-4. Molecular formula: C381H629N119O115S2. Mole weight: 8781.05.
pTH-Related Protein (1-34) (human,mouse,rat)
pTH-Related Protein (1-34) (human, mouse, rat), a fragment of parathyroid hormone-related protein, is an anabolic agent. pTH-Related Protein (1-34) (human, mouse, rat) can be used for postmenopausal osteoporosis study [1]. Uses: Scientific research. Group: Peptides. Alternative Names: pTHrP (1-34). CAS No. 112540-82-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P3075.
pTH-Related Protein (1-37) (human, mouse, rat)
pTH-Related Protein (1-37) (human, mouse, rat) is a parathyroid hormone-related protein sequence associated with malignant hypercalcemia. Synonyms: Hypercalcemia of Malignancy Factor (1-37) (human, mouse, rat); H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile-Arg-OH; Human parathyroid hormone-related peptide-1-37. Grades: 95%. CAS No. 206010-80-2. Molecular formula: C197H317N63O53. Mole weight: 4416.08.
(R)-1-(Naphthalen-1-yl)-N-(3-(trifluoromethyl)benzyl)ethanamine hydrochloride, is an impurity of Cinacalcet, which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels). Synonyms: (αR)-α-Methyl-N-[[3-(trifluoromethyl)phenyl]methyl]-1-naphthalenemethanamine Hydrochloride; Cinacalcet Impurity 18. CAS No. 1229225-42-6. Molecular formula: C20H19ClF3N. Mole weight: 365.82.
Ronacaleret hydrochloride
Ronacaleret hydrochloride (SB 751689A) is an orally active, potent, and selective calcium-sensing receptor (CaSR) antagonist that stimulates endogenous parathyroid hormone release from the parathyroid glands. Ronacaleret hydrochloride (SB 751689A) is used for the study of postmenopausal osteoporosis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SB 751689A. CAS No. 702686-96-2. Pack Sizes: 1 mg; 5 mg. Product ID: HY-15104.
Teriparatide
Teriparatide (Human parathyroid hormone-(1-34)) is a PTH1 receptor agonist. Teriparatide (Human parathyroid hormone-(1-34)) can be used for osteoporosis research [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Human parathyroid hormone-(1-34); hPTH (1-34). CAS No. 52232-67-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-P0059.
Teriparatide acetate hydrate
Teriparatide is a polypeptide and recombinant DNA form of parathyroid hormone consisting of 34 amino acids. It was approved by FDA for the treatment of certain types of osteoporosis. It also has a therapeutic activity for fragility fractures. Uses: The treatment of osteoporosis. Synonyms: L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate, hydrate (1:x:x); L-Phenylalanine, L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-, acetate (salt), hydrate; Teribone; H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH.CH3CO2H.H2O. Grades: 95%. CAS No. 99294-94-7. Molecular formula: C181H291N55O51S2.C2H4O2.xH2O. Mole weight: 4177.83 (anhydrous basis).
Tigapotide
PCK3145 is a synthetic 15-mer peptide corresponding to amino acids 31-45 of the 94-amino acid isoform of human prostate secretory protein (PSP-94) with potential anti-metastasis and anti-angiogenesis activities. PSP-94-derived peptide PCK3145 may inhibit the secretion of the metastasis-related protein matrix metalloproteinase-9 (MMP-9) and its potential binding to its cell surface receptor CD44; may interfere with the vascular endothelial growth factor (VEGF) signaling pathway, resulting in an anti-angiogenesis effect; and may reduce the levels of parathyroid hormone-related protein (PTHrP), decreasing plasma calcium levels. PSP-94, one of three predominant proteins found in seminal fluid, may be down-regulated in prostate cancer, representing a potential survival mechanism for prostate cancer cells. MMP-9 is implicated in the invasion and metastasis of cancer. PTHrP may be expressed by various tumor cell types, resulting in the hypercalcemia of malignancy. Synonyms: PCK3145. Chemical name: L-Threonine, L-glutamyl-L-tryptophyl-L-glutaminyl-L-threonyl-L--aspartyl-L-asparaginyl-S-[(acetylamino)methyl]-L-cysteinyl-L-glutamyl-L-threonyl-S-[(acetylamino)methyl]-L-cysteinyl-L-threonyl-S-[(acetylamino)methyl]-L-cysteinyl-L-t. CAS No. 848084-83-3. Molecular formula: C82H119N21O34S3. Mole weight: 2039.15.
TIP 39, Tuberoinfundibular Neuropeptide
It is a neuropeptide and parathyroid hormone 2 receptor (PTH2R) agonist. Synonyms: Ser-Leu-Ala-Leu-Ala-Asp-Asp-Ala-Ala-Phe-Arg-Glu-Arg-Ala-Arg-Leu-Leu-Ala-Ala-Leu-Glu-Arg-Arg-His-Trp-Leu-Asn-Ser-Tyr-Met-His-Lys-Leu-Leu-Val-Leu-Asp-Ala-Pro; TIP 39 (39 mer); L-seryl-L-leucyl-L-alanyl-L-leucyl-L-alanyl-L-alpha-aspartyl-L-alpha-aspartyl-L-alanyl-L-alanyl-L-phenylalanyl-L-arginyl-L-alpha-glutamyl-L-arginyl-L-alanyl-L-arginyl-L-leucyl-L-leucyl-L-alanyl-L-alanyl-L-leucyl-L-alpha-glutamyl-L-arginyl-L-arginyl-L-histidyl-L-tryptophyl-L-leucyl-L-asparagyl-L-seryl-L-tyrosyl-L-methionyl-L-histidyl-L-lysyl-L-leucyl-L-leucyl-L-valyl-L-leucyl-L-alpha-aspartyl-L-alanyl-L-proline. Grades: ≥95% by HPLC. CAS No. 277302-47-3. Molecular formula: C202H325N61O54S. Mole weight: 4504.17.
(Tyr1)-pTH (1-34) (human)
Synonyms: [Tyr1] Parathyroid Hormone (1-34), human; H-Tyr-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH. Grades: ≥95% by HPLC. CAS No. 213779-10-3. Molecular formula: C189H295N55O51S2. Mole weight: 4193.87.
(Tyr34)-pTH (7-34) amide (bovine)
(Tyr34)-pTH (7-34) amide (bovine) is an inhibitor of the action of parathyroid hormone in vivo. Synonyms: [Tyr34] Parathyroid Hormone (7-34), amide, bovine; H-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Tyr-NH2; L-Phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-3-(7H-indol-3-yl)-L-alanyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-tyrosinamide. Grades: ≥95% by HPLC. CAS No. 86292-93-5. Molecular formula: C156H244N48O40S2. Mole weight: 3496.03.
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