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Parathyroid hormone (1-34) (bovine) is a parathyroid hormone (PTH) receptor agonist. It increases calcium and inorganic phosphate levels in the serum of young rats. Parathyroid hormone (PTH) is the most important endocrine regulator of calcium and phosphorus concentration in extracellular fluid, which is secreted by the chief cell of the parathyroid glands as a polypeptide containing 84 amino acids. Synonyms: L-Phenylalanine, L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-phenylalanyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparaginyl-; ; Ala-Val-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe. CAS No. 12583-68-5. Molecular formula: C183H288N54O50S2. Mole weight: 4108.74.
Parathyroid Hormone (1-34), bovine
Parathyroid Hormone (1-34), bovine is a potent parathyroid hormone (PTH) receptor agonist. Parathyroid Hormone (1-34), bovine increases calcium and inorganic phosphate levels in vivo. Parathyroid Hormone (1-34), bovine can be used for th reseach of osteoporosis [1]. Uses: Scientific research. Group: Peptides. CAS No. 12583-68-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1252.
Parathyroid hormone (1-34) (human)
Parathyroid hormone (1-34) (human) is a fragment of human parathyroid hormone (hPTH) peptide sequence containing the 34 N-terminal residues of hPTH. PTH 1-34 induces bone morphogenetic protein (BMP) gene transcription. Teriparatidet is an effective anabolic (i.e., bone growing) agent used in the treatment of some forms of osteoporosis. It is also occasionally used off-label to speed fracture healing. Synonyms: PTH (1-34) (Human); L-seryl-L-valyl-L-seryl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparaginyl-L-leucylglycyl-L-lysyl-L-histidyl-L-leucyl-L-asparaginyl-L-seryl-L-methionyl-L-α-glutamyl-L-arginyl-L-valyl-L-α-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-α-aspartyl-L-valyl-L-histidyl-L-asparaginyl-L-Phenylalanine; (1-34)-Human parathormone; (1-34)-Human parathyroid hormone; 1-34-Human PTH; 1-34-Parathormone (human); H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; Parathar; Teriparatida; Forteo. Grade: ≥95%. CAS No. 52232-67-4. Molecular formula: C181H291N55O51S2. Mole weight: 4117.75.
Parathyroid hormone (1-34) (rat)
Parathyroid hormone (1-34) (rat), a synthetic, rat parathryroid hormone, is a parathyroid hormone (PTH) receptor agonist, which increases serum PTH levels and bone mass in rats. Synonyms: pTH (1-34) (rat). CAS No. 98614-76-7. Molecular formula: C180H291N55O48S2. Mole weight: 4057.74.
Parathyroid hormone (1-34) (rat)
Parathyroid hormone (1-34) (rat) is a parathyroid hormone. Parathyroid hormone (1-34) (rat) improves both cortical and cancellous bone structure. Parathyroid hormone (1-34) (rat) can be used for the research of osteoporosis [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 98614-76-7. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P2279.
Parathyroid hormone human is an indispensable compound, used in the research of rectifying hypoparathyroidism and osteoporosis. Synonyms: pTH (1-84) (human); H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-Gln-Arg-Pro-Arg-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asn-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-OH; Parathormone. Grade: ≥95%. CAS No. 68893-82-3. Molecular formula: C408H674N126O126S2. Mole weight: 9424.62.
Tissue, Membrane Protein, Human Adult Normal, Parathyroid HisTek
Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 100ug. US Biological Life Sciences.
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Tissue, Section, Human Adult Normal, Parathyroid (Frozen) HisTek
Tissue, Section, Human Adult Normal, Parathyroid (Frozen) HisTek. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 5 Sections. US Biological Life Sciences.
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Tissue, Section, Human Tumor, Parathyroid Tumor (Paraffin) HisTek
Paraffin tissue slides suitable for use in identifying cellular localization of RNA or protein using in situ hybridization or immunohistochemistry. Human tissue of ~5um thickness is paraffin embedded and mounted on a positively-charged glass slide. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 5 Sections. US Biological Life Sciences.
Worldwide
Tissue, Total Protein, Human Adult Normal, Parathyroid HisTek
Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Tissue, Total Protein, Human Tumor, Parathyroid HisTek
Tissue Protein Lysate produced under consistent processing conditions to ensure intact structure and original nature. Total protein is prepared from whole-tissue homogenates and presents a consistent pattern on SDS-PAGE analysis. Group: Biologicals. Grades: Molecular Biology Grade. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
1α-Hydroxy-3-epi-vitamin D3
1α-Hydroxy-3-epi-vitamin D3, a natural metabolite of 1α,25-dihydroxyvitamin D3, is a potent inhibitor of parathyroid hormone (PTH) secretion. Synonyms: 1,3-Cyclohexanediol, 5-[(2E)-2-[(1R,3aS,7aR)-1-[(1R)-1,5-dimethylhexyl]octahydro-7a-methyl-4H-inden-4-ylidene]ethylidene]-4-methylene-, (1S,3S,5Z)-; 1alpha-hydroxy-3-epicholecalciferol; (5Z,7E)-(1S,3S)-9,10-seco-5,7,10(19)-cholestatriene-1,3-diol; (1S,3S,5Z,7E)-9,10-Secocholesta-5,7,10-triene-1,3-diol. Grade: ≥98%. CAS No. 58028-00-5. Molecular formula: C27H44O2. Mole weight: 400.64.
1-(Naphthalen-1-yl)ethanone oxime
1-(Naphthalen-1-yl)ethanone oxime is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: Ethanone, 1-(1-naphthalenyl)-, oxime; (Z)-1-(1-Naphthalenyl)ethanone Oxime. CAS No. 100485-51-6. Molecular formula: C12H11NO. Mole weight: 185.22.
1-(Naphthalen-2-yl)ethanamine
1-(Naphthalen-2-yl)ethanamine is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: 1-(naphthalen-2-yl)ethan-1-amine; Cinacalcet Impurity 28. Grade: 95%. CAS No. 1201-74-7. Molecular formula: C12H13N. Mole weight: 171.24.
22Z-Paricalcitol
An impurity of Paricalcitol which is a man-made form of vitamin D to treat and prevent high levels of a certain natural substance made by the body (parathyroid hormone) in patients with long-term kidney disease. Synonyms: 22-Z-Paricalcitol; (1R,3R)-5-((E)-2-((1R,3aS,7aR)-1-((2R,5S,Z)-6-hydroxy-5,6-dimethylhept-3-en-2-yl)-7a-methylhexahydro-1H-inden-4(2H)-ylidene)ethylidene)cyclohexane-1,3-diol. Grade: > 95%. CAS No. 1884139-61-0. Molecular formula: C27H44O3. Mole weight: 416.65.
2-Naphthyl Cinacalcet
2-Naphthyl Cinacalcet is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: Cinacalcet Impurity 18; N-(1-(Naphthalen-2-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)propan-1-amine hydrochloride; 2-Naphthalenemethanamine, a-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride. CAS No. 1622173-74-3. Molecular formula: C22H23ClF3N. Mole weight: 393.88.
3-(3-Methylphenyl)propionic acid
3-(3-Methylphenyl)propionic acid, is an impurity of Cinacalcet, which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels). Synonyms: 3-m-tolylpropionic acid; Propionic acid, 3-[3-methylphenyl]-; Cinacalcet Impurity 34. CAS No. 3751-48-2. Molecular formula: C10H12O2. Mole weight: 164.20.
3-(3-Trifluoromethylphenyl)propionic acid
3-(3-Trifluoromethylphenyl)propionic acid, is an impurity of Cinacalcet, which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels). Synonyms: m-(Trifluoromethyl)hydrocinnamic acid; 3-Trifluoromethylbenzenepropanoic Acid; Cinacalcet Impurity 32. CAS No. 585-50-2. Molecular formula: C10H9F3O2. Mole weight: 218.17.
3-(Trifluoromethyl)cinnamic acid
3-(Trifluoromethyl)cinnamic acid is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: m-(trifluoromethyl)cinnamic acid; (E)-3-(3-(Trifluoromethyl)phenyl)acrylic acid; 3-(3-(Trifluoromethyl)phenyl)acrylic acid; Cinacalcet Impurity II. CAS No. 67801-07-4. Molecular formula: C10H7F3O2. Mole weight: 216.16.
A-75943
A-75943 is is a bone resorption inhibitor produced by Streptomyces sp. SANK61296. In vitro tests, it has the effect of inhibiting bone resorption with IC50 of 0.35 μmol/L. It also inhibits the bone resorption in rats with thyroid and parathyroidectomy. Synonyms: 2H-Pyran-4-acetamide, 2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)tetrahydro-6-oxo-, (2R,4S)-. Grade: >98%. CAS No. 201215-10-3. Molecular formula: C15H23NO4. Mole weight: 281.35.
Abaloparatide
Abaloparatide (BA 058) is a parathyroid hormone receptor 1 (PTHR1) analog. Abaloparatide also is a selective PTHR1 activator. Abaloparatide enhances Gs/cAMP signaling and β-arrestin recruitment. Abaloparatide enhances bone formation and cortical structure in mice. Abaloparatide has the potential for the research of osteoporosis [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: BA 058; BIM 44058. CAS No. 247062-33-5. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-108742.
Abaloparatide
Abaloparatide is an analogue of parathyroid hormone-related protein (PTHrP) which is used for the treatment of osteoporosis. In 28 April 2017, it was approved by FDA for the treatment of postmenopausal women with osteoporosis. Studies showed that abaloparatide could decrease the risk of new vertebral and nonvertebral fractures. Uses: The treatment of osteoporosis. Synonyms: Tymlos. Grade: 98%. CAS No. 247062-33-5. Molecular formula: C174H300N56O49. Mole weight: 3960.58.
Abaloparatide acetate
Abaloparatide acetate, an effective and selective activator of the PTHR1 signaling pathway, is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Synonyms: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2.CH3CO2H; L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide acetic acid. Grade: ≥95%. Molecular formula: C176H304N56O51. Mole weight: 4020.71.
Abaloparatide TFA
Abaloparatide TFA (BA 058 TFA) is a parathyroid hormone receptor 1 (PTHR1) analogue. Abaloparatide TFA also is a selective PTHR1 activator. Abaloparatide TFA enhances Gs/cAMP signaling and ?-arrestin recruitment. Abaloparatide TFA enhances bone formation and cortical structure in mice. Abaloparatide TFA has the potential for the research of osteoporosis[1][2]. Uses: Scientific research. Group: Peptides. Alternative Names: BA 058 TFA; BIM 44058 TFA. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-108742A.
Abaloparatide TFA
Abaloparatide TFA is an analog of parathyroid hormone-related protein (PTHrP) used for the treatment of osteoporosis. Synonyms: H-Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Glu-Leu-Leu-Glu-Lys-Leu-Leu-Aib-Lys-Leu-His-Thr-Ala-NH2.TFA; L-alanyl-L-valyl-L-seryl-L-alpha-glutamyl-L-histidyl-L-glutaminyl-L-leucyl-L-leucyl-L-histidyl-L-alpha-aspartyl-L-lysyl-glycyl-L-lysyl-L-seryl-L-isoleucyl-L-glutaminyl-L-alpha-aspartyl-L-leucyl-L-arginyl-L-arginyl-L-arginyl-L-alpha-glutamyl-L-leucyl-L-leucyl-L-alpha-glutamyl-L-lysyl-L-leucyl-L-leucyl-alpha-methyl-alanyl-L-lysyl-L-leucyl-L-histidyl-L-threonyl-L-alaninamide trifluoroacetic acid; BIM 44058 trifluoroacetate; Eladynos trifluoroacetate. Grade: ≥95%. Molecular formula: C176H301N56F3O51. Mole weight: 4074.61.
AH3960
AH3960 is an agonist of parathyroid hormone receptor-1 (PTHR1). Synonyms: Trione; AH 3960; AH-3960; 2,4,6(1H,3H,5H)-Pyrimidinetrione, 1,3-dibutyl-5-(diaminomethylene)-; 1,3-Dibutyl-5-(diaminomethylene)-2,4,6(1H,3H,5H)-pyrimidinetrione; 1,3-dibutyl-6-hydroxy-2,4-dioxo-1,2,3,4-tetrahydropyrimidine-5-carboximidamide. Grade: >98%. CAS No. 862907-48-0. Molecular formula: C13H22N4O3. Mole weight: 282.34.
(Asp76)-pTH (39-84) (human)
Asp76-pTH (39-84) (human) is a synthetic peptide widely utilized in the biomedical sector exhibiting its prowess as a potent receptor antagonist for parathyroid hormone (PTH), exerting pivotal influence over the intricate dynamics of calcium and phosphate metabolism. Synonyms: H-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-Gln-Arg-Pro-Arg-Lys-Lys-Glu-Asp-Asn-Val-Leu-Val-Glu-Ser-His-Glu-Lys-Ser-Leu-Gly-Glu-Ala-Asp-Lys-Ala-Asp-Val-Asp-Val-Leu-Thr-Lys-Ala-Lys-Ser-Gln-OH; 39-84-Parathormone (human); L-Alanyl-L-prolyl-L-leucyl-L-alanyl-L-prolyl-L-arginyl-L-α-aspartyl-L-alanylglycyl-L-seryl-L-glutaminyl-L-arginyl-L-prolyl-L-arginyl-L-lysyl-L-lysyl-L-α-glutamyl-L-α-aspartyl-L-asparaginyl-L-valyl-L-leucyl-L-valyl-L-α-glutamyl-L-seryl-L-histidyl-L-α-glutamyl-L-lysyl-L-seryl-L-leucylglycyl-L-α-glutamyl-L-alanyl-L-α-aspartyl-L-lysyl-L-alanyl-L-α-aspartyl-L-valyl-L-α-aspartyl-L-valyl-L-leucyl-L-threonyl-L-lysyl-L-alanyl-L-lysyl-L-seryl-L-glutamine; human parathormone (39-84). Grade: ≥95% by HPLC. CAS No. 79804-72-1. Molecular formula: C211H356N66O73. Mole weight: 4985.55.
Calcitonin is a hormone produced by the parafollicular cells (C-cells) of the thyroid gland. It plays a crucial role in calcium homeostasis by lowering blood calcium levels, opposing the actions of parathyroid hormone (PTH), which increases calcium levels. Calcitonin achieves this by inhibiting osteoclast activity, reducing bone resorption, and decreasing calcium reabsorption in the kidneys. It is also involved in phosphate regulation, lowering blood phosphate levels. In clinical settings, calcitonin has been used to treat conditions such as hypercalcemia, Paget's disease of bone, and osteoporosis. Synonyms: Calcitrin; TCA; TCT; Thyrocalcitonin; Thyrocalcitonins. Grade: 95%. CAS No. 9007-12-9.
Calcium-Sensing Receptor Antagonists I
Calcium-Sensing Receptor Antagonists I is an antagonist of calcium-sensing parathyroid hormone receptors. Synonyms: 2(1H)-Quinazolinone, 1-(1-methylethyl)-4-[4-(1-methylethyl)phenyl]-6-(2-propyn-1-yloxy)-. Grade: >98%. CAS No. 478963-79-0. Molecular formula: C23H24N2O2. Mole weight: 360.45.
Cinacalcet Impurity 17
Cinacalcet Impurity 17 is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: (R)-1-(7,8-DIHYDRONAPHTHALEN-1-YL)ETHAN-1-AMINE; 802918-45-2; (1R)-1-(7,8-dihydronaphthalen-1-yl)ethanamine; SCHEMBL13138362; Y13455. Grade: > 95%. CAS No. 802918-45-2. Molecular formula: C12H15N. Mole weight: 173.26.
Cinacalcet Impurity B (HCl salt form)
Cinacalcet Impurity B (HCl salt form) is an impurity of Cinacalcet, a medication used to treat secondary hyperparathyroidism in patients with chronic kidney disease and parathyroid carcinoma. Synonyms: (R)-(-)-N-BENZYL-1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE; (R)-N-BENZYL 1-(1-NAPHTHYL)ETHYLAMINE HYDROCHLORIDE; (R)-N-[1-(1-NAPHTHYL)ETHYL]BENZYLAMINE HYDROCHLORIDE; (R)-(-)-N-BENZYL-1-(1-NAPHTHYL)ETHYLAMI&; N-benzyl-1-(1-naphthyl)ethylamine hydrochloride. Grade: 95%. CAS No. 163831-65-0. Molecular formula: C19H20ClN. Mole weight: 297.82.
Cinacalcet Impurity E HCl
(αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine, is an impurity of Cinacalcet, which is is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels). Synonyms: (αR)-α-Methyl-N-[3-(3-methylphenyl)propyl]-1-naphthalenemethanamine Hydrochloride. Grade: > 95%. Molecular formula: C22H26ClN. Mole weight: 339.9.
Cinacalcet USP Related Compound C
Cinacalcet USP Related Compound C is an impurity of Cinacalcet, which is a drug that acts as a calcimimetic, and is used to treat secondary hyperparathyroidism (elevated parathyroid hormone levels). Synonyms: Cinacalcet Para-Trifluoromethyl Analog; (R)-N-(1-(Naphthalen-1-yl)ethyl)-3-(4-(trifluoromethyl)phenyl)propan-1-amine Hydrochloride; (alphaR)-alpha-Methyl-N-[3-[4-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethan. Grade: 95%. CAS No. 1428118-39-1. Molecular formula: C22H23ClF3N. Mole weight: 393.88.
Cinacalcet USP Related Compound E
Cinacalcet USP Related Compound E is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: 3-[3-(Trifluoromethyl)phenyl]-1-propanol. CAS No. 78573-45-2. Molecular formula: C10H11F3O. Mole weight: 204.19.
Dehydro Cinacalcet Hydrochloride
Dehydro Cinacalcet Hydrochloride is an impurity of Cinacalcet, a pharmaceutical drug employed for treating hyperparathyroidism among individuals afflicted by chronic renal disorders and parathyroid carcinoma. Synonyms: (R,E)-N-(1-(Naphthalen-1-yl)ethyl)-3-(3-(trifluoromethyl)phenyl)prop-2-en-1-amine HCl; Cinacalcet Impurity C. CAS No. 1207533-91-2. Molecular formula: C22H21ClF3N. Mole weight: 391.86.
Dihydrotachysterol
Dihydrotachysterol is a synthetic analog of vitamin D. Dihydrotachysterol can be used to for the research of hypocalcemia (lack of calcium in the blood) and hypoparathyroidism (lack of parathyroid hormone in the body) [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 67-96-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-A0245.
Dihydrotachysterol
Dihydrotachysterol is a vitamin D that can be regarded as a reduction product of vitamin D2 activated in the liver. It does not require renal hydroxylation like vitamin D2 and vitamin D3. It could stimulate intestinal calcium absorption and increases renal phosphate excretion. It is widely used for hypocalcemic hypoparathyroidism following surgical removal of parathyroids. Synonyms: HSDB 3314; Hytakerol; Parterol; Tachyrol; Dihydral; (1S,3E,4S)-4-Methyl-3-[(2E)-2-[(1R,3aS,7aR)-octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-onden-4-ylidene]ethylidene]cyclohexanol; (3β,5E,7E,10α,22E)-9,10-Secoergosta-5,7,22-trien-3-ol; 24-Methyl-9,10-secocholesta-5,7,22-trien-3β-ol; Antitanil; Calcamine; DHT2; Dichystrolum; Dihidrotaquisterol; (5E,7E,22E)-(3S,10S)-9,10-seco-5,7,22-ergostatrien-3-ol. Grade: 98%. CAS No. 67-96-9. Molecular formula: C28H46O. Mole weight: 398.66.
Dihydro Tachysterol
Dihydrotachysterol (DHT) is a synthetic vitamin D analog activated in the liver that does not require renal hydroxylation like vitamin D2 (ergocalciferol) and vitamin D3 (cholecalciferol). DHT has a rapid onset of action (2 hours), a shorter half-life, and a greater effect on mineralization of bone salts than does vitamin D. The half synthetic Vitamin D analogue dihydrotachysterol (DHT) is widely used for hypocalcaemic hypoparathyroidism following surgical removal of parathyroids. Such treatment generally initiated by surgeons right after surgery has to be continued in clinical practice. Unfortunately, the required careful monitoring of calcium metabolism is often lacking and as demonstrated may lead to life-threatening conditions. In comparison to short acting vitamin-D derivates hypercalcaemic episodes with DHT appear to last longer and may therefore occur with higher incidence. Group: Biochemicals. Alternative Names: (1S, 3E, 4S) -4-Methyl-3- [ (2E) -2- [ (1R, 3aS, 7aR) -octahydro-7a-methyl-1- [ (1R, 2E, 4R) -1, 4, 5-trimethyl-2-hexen-1-yl] -4H-onden-4-ylidene] ethylidene] cyclohexanol; (3 β, 5E, 7E, 10α, 22E)-9, 10-Secoergosta-5, 7, 22-trien-3-ol; 24-Methyl-9,10-secocholesta-5,7,22-trien-3 β-ol; Antitanil; Calcamine; DHT2; Dichystrolum; Dihydral; Tachyrol. Grades: Highly Purified. CAS No. 67-96-9. Pack Sizes: 10mg, 25mg, 50mg. Molecular Formula: C??H??O, Molecular Weight: 398.66. US Biological Life Sciences.
Worldwide
DPC AJ1951 acetate
DPC-AJ1951 is a potent 14 amino acid peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). Synonyms: DPCAJ1951 acetate. Molecular formula: C78H131N23O21. Mole weight: 1727.02.
DPC-AJ1951 trifluoroacetate salt
DPC-AJ1951 is a potent 14 amino acid peptide agonist of the parathyroid hormone (PTH)/PTH-related peptide receptor (PPR). It induces cAMP production in SAOS-2 and UMR106 cells that endogenously express human and rat PPR, respectively (EC50s = 2.2 and 1.1 nM, respectively). Synonyms: 2-methylalanyl-L-valyl-2-methylalanyl-L-α-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-norleucyl-L-histidyl-L-glutaminyl-L-arginyl-L-alanyl-L-lysyl-L-tyrosinamide, trifluoroacetate salt. Grade: ≥95%. CAS No. 943519-33-3. Molecular formula: C76H127N23O19·xCF3COOH. Mole weight: 1667.
DS69910557
DS69910557 is a potent, selective and orally activehuman parathyroid hormone receptor 1 (hPTHR1) antagonist. DS69910557 has antagonistic activity for PTHR1 with an IC50 value of 0.08 ?M. DS69910557 can be used for the research of hyperparathyroidism, hypercalcemia of malignancy and osteoporosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3032750-17-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-148350.
Elcatonin
Elcatonin is a calcitonin derivative used as an anti-parathyroid agent. Synonyms: Elcatonin Acetate. Grade: 98%. CAS No. 60731-46-6. Molecular formula: C148H244N42O47. Mole weight: 3363.82.
ENCALERET SULFATE
This active molecular is an CaSR (calcium-sensing receptor antagonist) under the developmet of Tobacco and Merck & Co. Calcium-sensing receptor is a member of the G protein-coupled receptor and it is very important to modulate Ca2+ homeostasis via its role in the parathyroid glands and kidneys. Encaleret was used for the treatment of osteoporosis., but was discontinued in Phase-II in Japan, India and USA in 2011. Uses: The treatment of osteoporosis. Synonyms: 4-[2-[(1R)-1-[(2R)-3-[[1-(4-chloro-3-fluorophenyl)-2-methylpropan-2-yl]amino]-2-hydroxypropoxy]ethyl]phenyl]-2-methylbenzoic acid; sulfuric acid; hydrate; JIT305; JIT 305; JIT-305. Grade: 98%. CAS No. 1214922-52-7. Molecular formula: C58H70Cl2F2N2O13S. Mole weight: 1144.16.
Etelcalcetide
Etelcalcetide is a calcimimetic agent used for the treatment of secondary hyperparathyroidism in patients chronic kidney disease (CKD) undergoing hemodialysis. It effects via binding to and stimulating the calcium-sensing receptor in the parathyroid gland. Uses: The treatment of secondary hyperparathyroidism. Synonyms: Velcalcetide; telcalcetide; AMG-416; KAI-4169; ONO-5163; Parsabiv. CAS No. 1262780-97-1. Molecular formula: C38H73N21O10S2. Mole weight: 1048.26.
Etelcalcetide hydrochloride
Etelcalcetide hydrochloride (AMG 416 hydrochloride; KAI-4169 hydrochloride) is a synthetic calcimimetic as an activator of the calcium sensing receptor (CaSR). Etelcalcetide hydrochloride is effective in lowering parathyroid hormone (PTH) concentrations in patients receiving dialysis with secondary hyperparathyroidism receiving hemodialysis, which is promising for research in the field of secondary hyperparathyroidism and chronic kidney disease [1] [2]. Uses: Scientific research. Group: Peptides. Alternative Names: Velcalcetide hydrochloride; AMG 416 hydrochloride; KAI-4169 hydrochloride. CAS No. 1334237-71-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-P1955A.
Etelcalcetide hydrochloride
Etelcalcetide is a calcium-sensing receptor agonist as a D-amino peptide calcimimetic for the treatment of secondary hyperparathyroidism. It can bind to and activate the CaSR (calcium-sensing receptor) in the parathyroid gland as an allosteric activator, resulting in PTH reduction and suppression. Amgen Inc. announced its submission of a New Drug Application to the FDA for etelcalcetide in Aug 2015. Synonyms: AMG-416; AMG 416; AMG416; Etelcalcetide hydrochloride; KAI-4169; KAI-4169-HCl; ONO-5163; Parsabiv; Telcalcetide; Velcalcetide; Velcalcetide hydrochloride; N-Acetyl-D-cysteinyl-D-alanyl-D-arginyl-D-arginyl-D-arginyl-D-alanyl-D-argininamide disulfide with L-cysteine hydrochloride; 1262780-97-1 (free). Grade: >98%. CAS No. 1334237-71-6. Molecular formula: C38H74ClN21O10S2. Mole weight: 1084.72.
Evocalcet
Evocalcet (KHK7580) is an orally active calcium sensing receptor ( CaSR ) agonist. Evocalcet inhibits the secretion of parathyroid hormone (PTH) from parathyroid gland cells. Evocalcet can be used for the research of hyperparathyroidism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: KHK7580. CAS No. 870964-67-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-17613.
FITC-abaloparatide
A Fluorescein isothiocyanate-attached Abaloparatide. Abaloparatide is a parathyroid hormone-related protein (PTHrP) analog drug used to treat osteoporosis. Grade: 95%.
Glutaurine
Glutaurine is an endogenous hormone found in the parathyroid and mammalian brain. This compound mimicks the anxiolytic drug diazepam, and has been identified as an antiepileptic. Synonyms: N-(2-Sulfoethyl)-L-glutamine; γ-Glutamyltaurine; γ-L-Glutamyltaurine; Litoralon; gamma-Glutamyltaurine; Glutaurinum. Grade: ≥95%. CAS No. 56488-60-9. Molecular formula: C7H14N2O6S. Mole weight: 254.26.
hPTHrP (1-36)
hPTHrP (1-36) has been shown to be one of the authentic secretory forms of PTHrP. Synonyms: Parathyroid hormone-related protein (1-36); Ala-Val-Ser-Glu-His-Gln-Leu-Leu-His-Asp-Lys-Gly-Lys-Ser-Ile-Gln-Asp-Leu-Arg-Arg-Arg-Phe-Phe-Leu-His-His-Leu-Ile-Ala-Glu-Ile-His-Thr-Ala-Glu-Ile. CAS No. 172867-62-8. Molecular formula: C191H305N59O52. Mole weight: 4260.10.
Obtusifolin, isolated from the seeds of Cassia obtusifolia , regulates the gene expression and production of MUC5AC mucin in airway epithelial cells via inhibiting NF-kB pathway [1]. Obtusifolin suppresses phthalate esters-induced breast cancer bone metastasis by targeting parathyroid hormone-related protein [2]. Uses: Scientific research. Group: Natural products. CAS No. 477-85-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N2098.
Osteostatin(1-5)amide(human,bovine,dog,horse,mouse,rabbit,rat). Uses: Designed for use in research and industrial production. Additional or Alternative Names: PTH-RELATED PROTEIN (107-111) AMIDE (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT);PTH-RELATED PROTEIN (107-111) AMIDE (HUMAN, RAT);PTH-RP (107-111) AMIDE (HUMAN, BOVINE, DOG, HORSE, MOUSE, RABBIT, RAT);PTH-RP (107-111) AMIDE (HUMAN, RAT);PARATHYROID HO. Product Category: Heterocyclic Organic Compound. CAS No. 155918-12-0. Molecular formula: C27H42N10O7. Mole weight: 618.69. Purity: 0.96. IUPACName: (2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-N-[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-1-oxopropan-2-yl]amino]-3-hydroxy-1-oxopropan-2-yl]-5-(diaminomethylideneamino)pentanamide. Canonical SMILES: CC(C(C(=O)NC(CCCN=C(N)N)C(=O)NC(CO)C(=O)NC(C)C(=O)NC(CC1=CNC2=CC=CC=C21)C(=O)N)N)O. Product ID: ACM155918120. Alfa Chemistry ISO 9001:2015 Certified.
Paricalcitol
Paricalcitol, a vitamin D analogue, is a vitamin D receptor agonist, used for the prevention and treatment of secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Uses: Scientific research. Group: Signaling pathways. CAS No. 131918-61-1. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50919.
Paricalcitol-[d6]
Paricalcitol-[d6] is the labelled analogue of Paricalcitol, which is used to treat and prevent secondary hyperparathyroidism (excessive secretion of parathyroid hormone) associated with chronic renal failure. Synonyms: Paricalcitol D6. Grade: 95% by HPLC; 95% atom D. CAS No. 2070009-67-3. Molecular formula: C27H38D6O3. Mole weight: 422.67.
PCO371
PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1613373-33-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg; 1 g. Product ID: HY-100856.
pTH (1-34) amide (human) is a compound synthetic peptide hormone is acts as an agonist to the parathyroid hormone receptor. It is employed for the research of osteoporosis, hypoparathyroidism and various bone-related disorders. Synonyms: H-Ser-Val-Ser-Glu-Ile-Gln-Leu-Met-His-Asn-Leu-Gly-Lys-His-Leu-Asn-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-NH2; Parathyroid hormone (1-34)amide; L-seryl-L-valyl-L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-leucyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-asparagyl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalaninamide; hPTH (1-34)-NH2; human parathyroid hormone (1-34) amide. Grade: 95%. CAS No. 83139-29-1. Molecular formula: C181H292N56O50S2. Mole weight: 4116.79.
pTH (28-48) (human) is an ingenious and cutting-edge compoundexpressly designed and meticulously formulated to scrutinize the profound and intricate ramifications inflicted by the coveted parathyroid hormone (PTH) upon the exceptionally intricate and multifarious research of bone metabolism and calcium homeostasis. Synonyms: Parathyroid Hormone (28-48), human; H-Leu-Gln-Asp-Val-His-Asn-Phe-Val-Ala-Leu-Gly-Ala-Pro-Leu-Ala-Pro-Arg-Asp-Ala-Gly-Ser-OH; L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanyl-L-valyl-L-alanyl-L-leucyl-glycyl-L-alanyl-L-prolyl-L-leucyl-L-alanyl-L-prolyl-L-arginyl-L-alpha-aspartyl-L-alanyl-glycyl-L-serine; Parathyroid Hormone Fragment 28-48 human. Grade: ≥95% by HPLC. CAS No. 83286-22-0. Molecular formula: C95H150N28O29. Mole weight: 2148.38.
pTH (3-34) (bovine)
pTH (3-34) (bovine) inhibits the stimulation of adenylate cyclase by pTH (1-34) in vitro, but has no agonist or antagonistic effect on renal phosphate transport in vivo. Synonyms: Parathyroid Hormone (3-34), bovine; H-Ser-Glu-Ile-Gln-Phe-Met-His-Asn-Leu-Gly-Lys-His-Leu-Ser-Ser-Met-Glu-Arg-Val-Glu-Trp-Leu-Arg-Lys-Lys-Leu-Gln-Asp-Val-His-Asn-Phe-OH; bPTH (3-34); L-seryl-L-alpha-glutamyl-L-isoleucyl-L-glutaminyl-L-phenylalanyl-L-methionyl-L-histidyl-L-asparagyl-L-leucyl-glycyl-L-lysyl-L-histidyl-L-leucyl-L-seryl-L-seryl-L-methionyl-L-alpha-glutamyl-L-arginyl-L-valyl-L-alpha-glutamyl-L-tryptophyl-L-leucyl-L-arginyl-L-lysyl-L-lysyl-L-leucyl-L-glutaminyl-L-alpha-aspartyl-L-valyl-L-histidyl-L-asparagyl-L-phenylalanine. Grade: ≥95% by HPLC. CAS No. 51257-86-4. Molecular formula: C175H274N52O48S2. Mole weight: 3938.55.