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| Product | Description | |
|---|---|---|
| renin | Formed from prorenin in plasma and kidney. In peptidase family A1 (pepsin A family). Group: Enzymes. Synonyms: angiotensin-forming enzyme; angiotensinogenase. Enzyme Commission Number: EC 3.4.23.15. CAS No. 9015-94-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4252; renin; EC 3.4.23.15; 9015-94-5; angiotensin-forming enzyme; angiotensinogenase. Cat No: EXWM-4252. |  |
| Renin from Human, Recombinant | Renin, also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin aldosterone system (RAAS)--also known as the renin-angiotensin-aldosterone axis--that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure. Renin is often improperly referred to as a hormone even though it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyses angiotensinogen to angiotensin I. Group: Enzymes. Synonyms: REN; HNFJ2; Renin; angiotensinogenase; Angiotensin forming enzyme. Enzyme Commission Number: EC 3.4.23.15. CAS No. 9015-94-5. Purity: >90%. Renin. Mole weight: ~52kDa (predicted is 38.3 kDa). Activity: >30U/mg. Stability: Avoid freeze/thaw cycles. After reconstitution, prepare aliquots and store at -80°C. Storage: at -20°C. Form: Lyophilized. In 25mM MES buffer containing 150mM NaCl. Source: HEK cells, Mature Renin (aa 67-406) is fused at the N-terminus to a FLAG-tag. Active form, does not contain prorenin peptide (aa 1-66). Species: Human. REN; HNFJ2; Renin; angiotensinogenase; Angiotensin forming enzyme. Cat No: NATE-1951. | |
| Renin from Mouse, recombinant | Renin, also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin aldosterone system (RAAS)--also known as the renin-angiotensin-aldosterone axis--that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure. Renin is often improperly referred to as a hormone even though it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyses angiotensinogen to angiotensin I. Group: Enzymes. Synonyms: CYMP; CYM; RENNIN; Chymosin. Enzyme Commission Number: EC 3.4.23.15. CAS No. 9015-94-5. Purity: > 90% by SDS-PAGE. Mole weight: The protein is fused with 6×his tag at the C-terminus and has a calculated MW of 43.2 kDa expressed. The predicted N-terminus is Leu24. Protein migrates as 45-55 kDa in reduced SDS-PAGE due to glycosylation. Activity: >25 pmol/min/ug. Storage: Store at -20°C. After reconstitution, aliquot and store at -20°C and use within 3 months. Avoid repeated freezing and thawing cycles. Form: Lyophilized from 0.22 μm filtered solution in PBS. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization. Source: HEK 293 cells. Species: Mouse. CYMP; CYM; RENNIN; Chymosin; REN; HNFJ2; Renin; angiotensinogenase. Cat No: NATE-1671. | |
| Renin Inhibitor (Aliskiren Hemifumarate) | A non-peptide, direct renin inhibitor (IC50 = 0.6nM for human renin) and an anti-hypertensive agent. Aliskiren confers neuronal resistance to A beta toxicity in primary rat cortical cultures. Group: Biochemicals. Alternative Names: (2S,4S,5S,7S)-N-(2-Carbamoyl-2-methylpropyl)-5-amino-4-hydroxy-2,7-diisopropyl-8-[4-methoxy-3-(3-methoxypropoxy)phenyl]-octanamide Hemifumarate. Grades: Highly Purified. CAS No. 173334-58-2. Pack Sizes: 5mg. US Biological Life Sciences. |  Worldwide |
| Renin Substrate 1 | A fluorogenic substrate for human renin. Upon cleavage by renin, the product (peptide-EDANS) emits fluorescence and can be easily analyzed using an excitation wavelength of 340 nm and emission wavelengths of 485-510 nm. Synonyms: H-Arg-Glu(EDANS)-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Thr-Lys(DABCYL)-Arg-OH; L-Arginine, L-arginyl-N-[2-[(5-sulfo-1-naphthalenyl)amino]ethyl]-L-glutaminyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-L-threonyl-N6-[4-[[4-(dimethylamino)phenyl]azo]benzoyl]-L-lysyl-. Grade: ≥95%. CAS No. 791068-69-4. Molecular formula: C109H156N32O21S. Mole weight: 2282.67. |  |
| Angiotensinogen(tetradecapeptide renin substrate), 5-L-isoleucine- (9CI) | Angiotensin is a peptide hormone that causes vasoconstriction and an increase in blood pressure. Synonyms: Hypertensinogen; Porcine renin substrate tetradecapeptide. CAS No. 20845-02-7. Molecular formula: C85H123N21O20. Mole weight: 1759. | |
| γ-renin | A member of the tissue kallikrein family, from submandibular glands of male mice. In peptidase family S1 (trypsin family). Group: Enzymes. Enzyme Commission Number: EC 3.4.21.54. CAS No. 85270-20-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4146; γ-renin; EC 3.4.21.54; 85270-20-8. Cat No: EXWM-4146. | |
| Native Human Renin | Renin, also known as an angiotensinogenase, is an enzyme that participates in the body's renin-angiotensin aldosterone system (RAAS)--also known as the renin-angiotensin-aldosterone axis--that mediates extracellular volume (i.e., that of the blood plasma, lymph and interstitial fluid), and arterial vasoconstriction. Thus, it regulates the body's mean arterial blood pressure. Renin is often improperly referred to as a hormone even though it has no peripheral receptors and rather has an enzymatic activity with which it hydrolyses angiotensinogen to angiotensin I. Applications: Research elisa assay life science clinical chemistry. Group: Enzymes. Synonyms: REN; HNFJ2; Renin; angiotensinogenase. CAS No. 9015-94-5. Renin. Activity: >90% (>0.5 U/mg). Storage: 4°C. Source: Human Kidney. Species: Human. REN; HNFJ2; Renin; angiotensinogenase. Cat No: NATE-0650. | |
| 1,4-Anhydro-6-chloro-6-deoxy-D-glucitol | 1,4-Anhydro-6-chloro-6-deoxy-D-glucitol, an organic compound, holds significant importance as an intermediate in the synthesis of various drugs including renin inhibitors and statins. Despite its major industrial significance, 1,4-Anhydro-6-chloro-6-deoxy-D-glucitol has also caught the attention of research scientists due to its anti-diabetic potential via the inhibition of glucose uptake. Its versatile utility in the medicinal domain makes 1,4-Anhydro-6-chloro-6-deoxy-D-glucitol an intriguing and promising candidate for further exploration. Molecular formula: C6H11ClO4. Mole weight: 182.61. | |
| (17α)-17-Hydroxy-3-oxo-pregna-4,6,20-triene-21-carboxylic Acid γ-Lactone | (17α)-17-Hydroxy-3-oxo-pregna-4,6,20-triene-21-carboxylic Acid γ-Lactone is an intermediate in synthesizing 20,21-Dehydro Spironolactone (D229405), which is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 52845-58-6. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C22H26O3. US Biological Life Sciences. | Worldwide |
| 17α-Ethoxymethyl 6-Dehydrotestosterone | 17α-Ethoxymethy 6-Dehydrotestosterone is an intermediate in the synthesis of 7 β-Acetylthio-17α-ethoxymethy Testosterone which is an impurity of Spironolactone (S683000), which is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C22H32O3. US Biological Life Sciences. | Worldwide |
| 17α-Ethynyltestosterone Acryl Ester | 17α-Ethynyltestosterone Acryl Ester is an intermediate in synthesizing 20,21-Dehydro Spironolactone (D229405), which is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C24H30O3. US Biological Life Sciences. | Worldwide |
| 17α-Vinyltestosterone Acryl Ester | 17α-Vinyltestosterone Acryl Ester is an intermediate in synthesizing 20,21-Dehydro Spironolactone (D229405), which is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 5mg, 10mg. Molecular Formula: C24H32O3. US Biological Life Sciences. | Worldwide |
| 17 β-Spiro[5-androsten-17,2'-oxiran]-3 β-ol | 17 β-Spiro[5-androsten-17,2'-oxiran]-3 β-ol is an intermediate in the synthesis of 7 β-Acetylthio-17α-ethoxymethy Testosterone which is an impurity of Spironolactone (S683000), which is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 847-75-6. Pack Sizes: 25mg, 50mg. Molecular Formula: C20H30O2. US Biological Life Sciences. | Worldwide |
| 17-(Ethoxymethyl) Androst-5-ene-3 β,17 β-diol | 17-(Ethoxymethyl) Androst-6-ene-3 β,17 β-diol is an intermediate in the synthesis of 7 β-Acetylthio-17α-ethoxymethy Testosterone which is an impurity of Spironolactone (S683000), which is a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 855-49-2. Pack Sizes: 10mg, 25mg. Molecular Formula: C22H36O3. US Biological Life Sciences. | Worldwide |
| 17-Hydroxy-3-oxo-17α-pregna-4,20-diene-21-carboxylic Acid γ-Lactone | 17-Hydroxy-3-oxo-17α-pregna-4,20-diene-21-carboxylic Acid γ-Lactone is an intermediate in synthesizing 20,21-Dehydro Spironolactone (D229405), which is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 52845-59-7. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C22H28O3. US Biological Life Sciences. | Worldwide |
| 1-O-Palmityl-2,3-dipalmitoyl-rac-glycerol | 1-O-Palmityl-2,3-dipalmitoyl-rac-glycerol may be able to inhibit human renin activity. Group: Biochemicals. Grades: Highly Purified. CAS No. 1116-45-6. Pack Sizes: 1mg, 5mg. Molecular Formula: C51H100O5, Molecular Weight: 793.34. US Biological Life Sciences. | Worldwide |
| 1-O-Palmityl-2,3-dipalmitoyl-rac-glycerol-d5 | 1-O-Palmityl-2,3-dipalmitoyl-rac-glycerol-d5 is labelled 1-O-Palmityl-2,3-dipalmitoyl-rac-glycerol (P163730) which may be able to inhibit human renin activity. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 2.5mg, 5mg. Molecular Formula: C51H95D5O5, Molecular Weight: 798.37. US Biological Life Sciences. | Worldwide |
| 20,21-Dehydro Spironolactone | 20,21-Dehydro Spironolactone (Spironolactone EP Impurity A) is an impurity of Spironolactone (S683000), a synthetic 17-lactone steroid which is a renal competitive aldosterone antagonist in a class of pharmaceuticals called potassium-sparing diuretics, used primarily to treat ascites in patients with liver disease, low-renin hypertension, hypokalemia, and Conns syndrome. Group: Biochemicals. Grades: Highly Purified. CAS No. 132458-33-4. Pack Sizes: 2.5mg, 25mg. Molecular Formula: C24H30O4S. US Biological Life Sciences. | Worldwide |
| 2,2,2-Trifluoroacetaldehyde (72% in aqueous solution) Monohydrate | 2,2,2-Trifluoroacetaldehyde Monohydrate is used in the synthesis of GABAB agonists which may be used in the therapeutic treatment of pain. Also used in the synthesis of ketone based inhibitors of human renin. Group: Biochemicals. Alternative Names: Fluoral Monohydrate; 2,2,2-Trifluoroacetaldehyde Monohydrate; Fluoral (aldehyde) Monohydrate; NSC 9446 Monohydrate; Trifluoroacetaldehyde Monohydrate; Trifluoroethanal Monohydrate; Trifluoromethyl Aldehyde Mnohydrate. Grades: Highly Purified. Pack Sizes: 1g. US Biological Life Sciences. | Worldwide |
| 2,2-Difluoro-1,3-benzodioxole | 2,2-Difluoro-1,3-benzodioxole is used in the synthesis of Kv3 inhibitors as well as in the preparation of renin inhibitors. Group: Biochemicals. Alternative Names: 1, 2-[ (Difluoromethylene) dioxy]benzene; 2,2-Difluoro-1,3-benzodioxole; 2,2-Difluorobenzodioxole. Grades: Highly Purified. CAS No. 1583-59-1. Pack Sizes: 10g. US Biological Life Sciences. | Worldwide |
| 2-(4-Bromophenoxy)-ethanol | 2-(4-Bromophenoxy)-ethanol is a useful synthetic intermediate. It was used in the synthesis of lithium 2- (4-lithiophenoxy) ethoxide. It was also used to prepare aryl-substituted diazabicyclononene carboxamides as potent renin inhibitors. Group: Biochemicals. Grades: Highly Purified. CAS No. 34743-88-9. Pack Sizes: 2.5g, 10g. Molecular Formula: C8H9BrO2, Molecular Weight: 217.06. US Biological Life Sciences. | Worldwide |
| (2R,4R,5R,7S)-Aliskiren Fumarate (2:1) | (2R,4R,5R,7S)-Aliskiren Fumarate (2:1) is an isomer of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 500ug, 5mg. Molecular Formula: C64H110N6O16, Molecular Weight: 1219.58999999999. US Biological Life Sciences. | Worldwide |
| (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic Acid | (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid is a component of a renin inhibitor and bestatin. Group: Biochemicals. Grades: Highly Purified. CAS No. 59554-14-2. Pack Sizes: 50mg, 100mg. Molecular Formula: C10H13NO3, Molecular Weight: 195.22. US Biological Life Sciences. | Worldwide |
| (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid-d7 | (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid-d7 is labelled (2S,3R)-3-Amino-2-hydroxy-4-phenylbutanoic acid which is a component of a renin inhibitor and bestatin. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 1mg, 2.5mg. Molecular Formula: C10H6D7NO3, Molecular Weight: 202.26. US Biological Life Sciences. | Worldwide |
| (2S,4S,5S,7R)-Aliskiren Fumarate (2:1) | (2S,4S,5S,7R)-Aliskiren Fumarate (2:1) is an isomer of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive. Group: Biochemicals. Grades: Highly Purified. CAS No. 1630036-82-6. Pack Sizes: 500ug, 5mg. Molecular Formula: C64H110N6O16, Molecular Weight: 1219.58999999999. US Biological Life Sciences. | Worldwide |
| 5-Azido-5-desamino Aliskiren-d6 | Intermediate in the preparation of renin inhibitors. Group: Biochemicals. Alternative Names: (2S,4S,5S,7S)-5-Azido-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxypropoxy)benzyl]-8-methylnonanoic acid (2-carbamoyl-2-methylpropyl)amide-d6; (αS, γS, δS, ζS)-N-(3-amino-2, 2-dimethyl-3-oxopropyl)-δ-azido-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α, ζ-bis(1-methylethyl)-benzeneoctanamide-d6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| 5(S)-[1(S)-Azido-3(S)-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3(S)-isopropyldihydrofuran-2-one | 5(S)-[1(S)-Azido-3(S)-[4-methoxy-3-(3-methoxypropoxy)benzyl]-4-methylpentyl]-3(S)-isopropyldihydrofuran-2-one is an intermediate in the preparation of orally active renin inhibitor Aliskiren. Group: Biochemicals. Alternative Names: (3S, 5S) -5-[ (1S, 3S) -1-Azido-3-[[4-methoxy-3- (3-methoxypropoxy) phenyl]methyl]-4-methylpentyl]dihydro-3- (1-methylethyl) -2 (3H) -furanone. Grades: Highly Purified. CAS No. 324763-46-4. Pack Sizes: 250mg. US Biological Life Sciences. | Worldwide |
| Ac-asp-arg-val-tyr-ile-his-pro-phe-his-leu-val-ile-his-asn-oh | Ac-asp-arg-val-tyr-ile-his-pro-phe-his-leu-val-ile-his-asn-oh. Uses: Designed for use in research and industrial production. Additional or Alternative Names: ACETYL-PREANGIOTENSINOGEN (1-14) (HUMAN);ACETYL-TETRADECAPEPTIDE RENIN SUBSTRATE (HUMAN);ACETYL-ANGIOTENSINOGEN (1-14) (HUMAN);AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN;AC-ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS-LEU-VAL-ILE-HIS-ASN-OH;N-acet. Product Category: Heterocyclic Organic Compound. CAS No. 104180-27-0. Molecular formula: C85H124N24O20. Mole weight: 1802.04. Product ID: ACM104180270. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Acetyl Angiotensinogen (1-14), porcine | Acetyl-angiotensinogen (1-14), porcine is encoded by the angiotensinogen gene and is known as a pre-angiotensinogen or angiotensinogen precursor. Synonyms: Angiotensinogen (tetradecapeptide renin substrate), N-acetyl-5-L-isoleucine-; Ac-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Leu-Val-Tyr-Ser-OH; N-acetyl-L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-valyl-L-tyrosyl-L-serine. Grade: 95%. CAS No. 66641-26-7. Molecular formula: C87H125N21O21. Mole weight: 1801.05. | |
| ACT 178882 | ACT 178882 is a novel Renin inhibitor (IC50= 1.4 nM). Synonyms: ACT 178882, ACT-178882, ACT178882; MK-1597; MK1597; MK 1597; (3R,4S)-N-[[2-chloro-5-(2-methoxyethyl)phenyl]methyl]-N-cyclopropyl-4-[6-[2-(2,6-dichloro-4-methylphenoxy)ethoxy]pyridin-3-yl]piperidine-3-carboxamide. CAS No. 1007392-69-9. Molecular formula: C33H38Cl3N3O4. Mole weight: 647.03. | |
| Alamandine | Alamandine, a member of the renin-angiotensin system (RAS), a vasoactive peptide, is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions[1][2]. Uses: Scientific research. Group: Peptides. CAS No. 1176306-10-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P3108. |  |
| Alamandine | Alamandine is a vasoactive peptide belonging to the renin-angiotensin system (RAS). It is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions. Synonyms: alamandine; 1176306-10-7; (2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylbutanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-methylpentanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]pyrrolidine-2-carboxylic acid; L-Alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline; GTPL6065; CHEBI:190281; HY-P3108; AKOS040755865; MS-31578; CS-0145495; C20971. Grade: 98%. CAS No. 1176306-10-7. Molecular formula: C40H62N12O9. Mole weight: 855.00. | |
| Alamandine TFA | Alamandine is a vasoactive peptide belonging to the renin-angiotensin system (RAS). It is an endogenous ligand of the G protein-coupled receptor MrgD. Alamandine targets to protect the kidney and heart through anti-hypertensive actions. Synonyms: H-Ala-Arg-Val-Tyr-Ile-His-Pro-OH.TFA; L-alanyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-proline trifluoroacetic acid. Grade: ≥95%. CAS No. 2863659-13-4. Molecular formula: C40H62N12O9.C2HF3O2. Mole weight: 969.02. | |
| Aldosterone | Aldosterone is the primary mineralocorticoid. Aldosterone is a steroid hormone, and it is synthesized and secreted in response to renin-angiotensin system activation (RAS) or high dietary potassium by the zona glomerulosa (ZG) of the adrenal cortex. Aldosterone activity is dependent by the binding and activation of the cytoplasmic/nuclear mineralocorticoid receptor (MR) at cellular level [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 52-39-1. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-113313. | |
| Aliskiren | Aliskiren hemifumarate appears to bind to both the hydrophobic S1/S3-binding pocket and to a large, distinct subpocket that extends from the S3-binding site towards the hydrophobic core of renin. Oral bioavailability of Aliskiren hemifumarate is 2.4% in rats, 16% in marmosets and about 2.5% in humans. Aliskiren hemifumarate (< 10 mg/kg, oral) inhibits plasma renin activity and lowers blood pressure in sodium-depleted marmosets.Once-daily oral treatment with Aliskiren hemifumarate lowers blood pressure effectively, with a safety and tolerability profile, in patients with mild-to-moderate hypertension. Uses: Antihypertensive agent; renin; antagonists and inhibitors. Synonyms: CGP 60536; CGP60536B; Rasilez; SPP 100; Tekturna. Grade:>98%. CAS No. 173334-57-1. Molecular formula: C30H53N3O6. Mole weight: 551.76. | |
| Aliskiren | Aliskiren is an orally active, highly potent and selective renin inhibitor, with IC 50 of 1.5 nM. Aliskiren can be used for the research of hypertension, cardiovascular diseases and cancer cachexia [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGP 60536; CGP60536B; SPP 100. CAS No. 173334-57-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12176. | |
| Aliskiren-[d6] Hydrochloride | An orally active, labelled synthetic nonpeptide renin inhibitor. Antihypertensive. Synonyms: Aliskiren-d6 Hydrochloride. Grade: 95% by HPLC; 95% atom D. CAS No. 1246815-96-2. Molecular formula: C30H48D6ClN3O6. Mole weight: 594.26. | |
| Aliskiren-d6 Hydrochloride | An orally active, labeled synthetic nonpeptide renin inhibitor. Antihypertensive. Group: Biochemicals. Alternative Names: (α S, γ S, δ S, ζ S) -δ -Amino-N- (3-amino-2, 2-dimethyl-3-oxopropyl) -γ -hydroxy-4-methoxy-3- (3-methoxypropoxy) -α , z-bis (1-methylethyl) benzeneoctanamide-d6 Hydrochloride; CGP 60536-d6; CGP60536B-d6; Rasilez-d6 Hydrochloride; SPP 100-d6; Tekturna Hydrochloride-d6. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Aliskiren hemifumarate | Aliskiren (CGP 60536; CGP60536B; SPP 100) hemifumarate is an orally active and selective renin inhibitor, with IC 50 of 1.5 nM. Aliskiren hemifumarate can be used for the research of hypertension, cardiovascular diseases and cancer cachexia [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CGP 60536 hemifumarate; CGP60536B hemifumarate; SPP 100 hemifumarate. CAS No. 173334-58-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12177. | |
| Aliskiren hemifumarate | Aliskiren is a direct renin inhibitor used for the treatment of essential hypertension. Synonyms: (αS,γS,δS,zS)-δ-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-γ-hydroxy-4-methoxy-3-(3-methoxypropoxy)-α,z-bis(1-methylethyl)benzeno-4-hydroxy-2-isopropyl-7-[4-methoxy-3-(3-methoxy-propoxy)-benzyl]-8-methyl-nonaoyl-2-methyl-propyl)-amide hemifumarate. Grade: 99%. CAS No. 173334-58-2. Molecular formula: C30H53N3O6·1/2C4H4O4. Mole weight: 1219.6. | |
| Aliskiren Hemifumarate | An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive. Group: Biochemicals. Alternative Names: (α S, γ S, δ S, zS) -δ -Amino-N- (3-amino-2, 2-dimethyl-3-oxopropyl) -γ -hydroxy-4-methoxy-3- (3-methoxypropoxy) -α , z-bis (1-methylethyl) benzeneoctanamide Hemifumarate; CGP 60536; CGP60536B; Rasilez Hemifumarate; SPP 100; Tekturna Hemifumarate. Grades: Highly Purified. CAS No. 173334-58-2. Pack Sizes: 1mg, 2mg, 5mg, 10mg. US Biological Life Sciences. | Worldwide |
| Aliskiren Hydrochloride | An orally active, synthetic nonpeptide renin inhibitor. Antihypertensive. Group: Biochemicals. Alternative Names: (α S, γ S, δ S, zS) -δ -Amino-N- (3-amino-2, 2-dimethyl-3-oxopropyl) -γ -hydroxy-4-methoxy-3- (3-methoxypropoxy) -α , z-bis (1-methylethyl) benzeneoctanamide Hydrochloride; CGP 60536; CGP60536B; Rasilez Hydrochloride; SPP 100; Tekturna Hydrochloride. Grades: Highly Purified. CAS No. 173399-03-6. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| Angiotensin 1/2 (5-7) acetate | The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I is hydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. Molecular formula: C19H31N5O6. Mole weight: 425.49. | |
| Angiotensin Acetate | Angiotensin acetate is an angiotensin II analog that is an agonist at angiotensin receptors. It is an oligopeptide and is a hormone and a powerful dipsogen. It is derived from the precursor molecule angiotensinogen, a serum globulin produced in the liver. It is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. It is part of the renin-angiotensin system, which is a major target for drugs that lower blood pressure. It plays an important role in the renin-angiotensin system. It also stimulates the release of aldosterone, another hormone, from the adrenal cortex. Uses: Angiotensin acetate causes vasoconstriction and a subsequent increase in blood pressure. it plays an important role in the renin-angiotensin system. Synonyms: ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE; H-ASP-ARG-VAL-TYR-VAL-HIS-PRO-PHE-OH; Angiotensin II 5-valine; Valine angiotensin II; 5-L-Valine angiotensin II. Grade: 98%. CAS No. 58-49-1. Molecular formula: C49H69N13O12. Mole weight: 1032.15. | |
| Angiotensin Fragment 1-7 acetate | Angiotensin Fragment 1-7 is a major active component of the renin-angiotensin system (RAS), produced from cleavage of Ang II by angiotensin-converting-enzyme type 2 (ACE2). Angiotensin 1-7 inhibits purified canine ACE activity with IC50 of 0.65 μM. This peptide can be generated by the action of ACE2, a homolog of ACE, on angiotensin II or by the action of neprilysin on angiotensin I. It has been studied in the context of ameliorating the symptoms of metabolic syndrome. Synonyms: 5-L-isoleucine-1-7-angiotensin II; Ang-(1-7). Grade: ≥95%. Molecular formula: C41H62N12O11·xC2H4O2. Mole weight: 899. | |
| Angiotensin I (human, rat, mouse) trifluoroacetate salt | Angiotensin I is formed from angiotensinogen by the action of renin, which is released from the kidney juxtaglomerular cells. Angiotensin I is further cleaved to angiotensin II by angiotensin converting enzyme. Angiotensin is a protein hormone that causes blood vessels to become narrower. It helps to maintain blood pressure and fluid balance in the body. It binds to angiotensin receptors in human myometrium membrane preparations with Kd of 11.2 nM and increases renal vascular resistance in isolated rat kidney with EC50 of 10.5 nM. Grade: ≥95%. Molecular formula: C62H89N17O14·xCF3COOH. Mole weight: 1296.48. | |
| Angiotensin II human | Angiotensin II (Angiotensin II) is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human also induces apoptosis. Angiotensin II induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4]. Uses: Scientific research. Group: Peptides. Alternative Names: Angiotensin II; Ang II; DRVYIHPF. CAS No. 4474-91-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13948. | |
| Angiotensin II human acetate | Angiotensin II human (Angiotensin II) acetate is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human acetate plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human acetate stimulates sympathetic nervous stimulation, increases aldosterone biosynthesis and renal actions. Angiotensin II human acetate induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human acetate also induces apoptosis. Angiotensin II human acetate induces capillary formation from endothelial cells via the LOX-1 dependent redox-sensitive pathway[1][2][3][4]. Uses: Scientific research. Group: Peptides. Alternative Names: Angiotensin II acetate; Ang II acetate; DRVYIHPF acetate. CAS No. 68521-88-0. Pack Sizes: 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13948A. | |
| Angiotensin II human TFA | Angiotensin II human TFA is a vasoconstrictor and a major bioactive peptide of the renin/angiotensin system. Angiotensin II human TFA plays a central role in regulating human blood pressure, which is mainly mediated by interactions between Angiotensin II and the G-protein-coupled receptors (GPCRs) Angiotensin II type 1 receptor (AT1R) and Angiotensin II type 2 receptor (AT2R). Angiotensin II human TFA induces growth of vascular smooth muscle cells, increases collagen type I and III synthesis in fibroblasts, leading to thickening of the vascular wall and myocardium, and fibrosis. Angiotensin II human TFA also induces apoptosis. Synonyms: Angiotensin II TFA; Ang II TFA; DRVYIHPF TFA. Grade: 99%. Molecular formula: C52H72F3N13O14. Mole weight: 1160.20. | |
| Angiotensin I/II (1-6) (TFA) | Angiotensin I/II (1-6) TFA is converted from Angiotensin I/II peptide. The precursor angiotensinogen is cleaved by renin to form angiotensin I. Angiotensin I is hydrolyzed by angiotensin-converting enzyme (ACE) to form the biologically active angiotensin II. Angiotensin II has been investigated for the treatment, basic science, and diagnostic of Hypertension, Renin Angiotensin System, and Idiopathic Membranous Nephropathy. Synonyms: Angiotensin I/II (1-6) (TFA); HY-P1829A; MS-31710; CS-0167697. Grade: 98%. Molecular formula: C38H56F3N11O12. Mole weight: 915.91. | |
| Angiotensinogen (1-14), human | Angiotensinogen (1-14), human is a fragment of the renin substrate angiotensinogen. Angiotensinogen is naturally occurring substrate for renin and a precursor for all angiotensin peptides [1] [2]. Uses: Scientific research. Group: Peptides. CAS No. 104180-23-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P1486. | |
| Angiotensinogen (1-14), human | Angiotensinogen (1-14), human is a fragment of the renin substrate Angiotensinogen, a precursor for all angiotensin peptides. Synonyms: H-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-Leu-Val-Ile-His-Asn-OH; L-alpha-aspartyl-L-arginyl-L-valyl-L-tyrosyl-L-isoleucyl-L-histidyl-L-prolyl-L-phenylalanyl-L-histidyl-L-leucyl-L-valyl-L-isoleucyl-L-histidyl-L-asparagine; Renin Substrate Tetradecapeptide human. Grade: 95%. CAS No. 104180-23-6. Molecular formula: C83H122N24O19. Mole weight: 1760.00. | |
| Atrial natriuretic factor (1-28) (human, porcine) | Atrial natriuretic factor (1-28) (human, porcine) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Synonyms: ANF 1-28; hANF; Atrial Natriuretic Peptide human. CAS No. 91917-63-4. Molecular formula: C127H205N45O39S3. Mole weight: 3080.46. | |
| Atrial Natriuretic Peptide (ANP) (1-28), rat | Atrial natriuretic factor (1-28) (rat) is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. It decreases plasma renin activity and cAMP levels in anesthetized rats and increases cGMP levels at 8 μg/kg. It also inhibits the arginine vasopressin-induced increase in mean arterial blood pressure in spontaneously hypertensive and control rats when administered intracerebroventricularly at a dose of 150 ng. It produces diuretic, natriuretic and vasodilatory effects through stimulation of guanylate cyclase-linked NPR-A receptors. It plays an important role in blood volume and blood pressure regulation. Uses: Vasodilator agents. Synonyms: Atrial natriuretic factor (1-28) (rat); rANP; Atrial Natriuretic Peptide rat; Cardiodilatin-126; Atrial Natriuretic Factor (1-28) (mouse, rabbit, rat); rANF (1-28); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys(1)-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys(1)-Asn-Ser-Phe-Arg-Tyr-OH; L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-isole. Grade: ≥95%. CAS No. 88898-17-3. Molecular formula: C128H205N45O39S2. Mole weight: 3062 | |
| Atrial Natriuretic Peptide (ANP) (1-28), rat TFA | Atrial Natriuretic Peptide (ANP) (1-28), rat TFA is a 28 amino acid peptide corresponding to the rat protein sequence. It is an endogenous peptide synthesized in myoendocrine cells of the heart from which it is released into the circulation. It has effects on the renal and cardiovascular systems that decrease vasoconstriction, increase sodium excretion and inhibit renin secretion. Synonyms: Atrial natriuretic factor (1-28) (rat) (TFA); H-Ser-Leu-Arg-Arg-Ser-Ser-Cys(1)-Phe-Gly-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys(1)-Asn-Ser-Phe-Arg-Tyr-OH.TFA; L-seryl-L-leucyl-L-arginyl-L-arginyl-L-seryl-L-seryl-L-cysteinyl-L-phenylalanyl-glycyl-glycyl-L-arginyl-L-isoleucyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-glycyl-L-alanyl-L-glutaminyl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-asparagyl-L-seryl-L-phenylalanyl-L-arginyl-L-tyrosine (7->23)-disulfide trifluoroacetic acid. Grade: >98%. Molecular formula: C128H205N45O39S2.C2HF3O2. Mole weight: 3176.43. | |
| Benzyl 5-Hydroxypentanoate | Benzyl 5-Hydroxypentanoate is used in the synthetic preparation of P2-P1-linked macrocyclic human renin inhibitors. Group: Biochemicals. Alternative Names: 5-Hydroxy Pentanoic Acid Phenylmethyl Ester. Grades: Highly Purified. CAS No. 134848-96-7. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| Boc-β-cyclohexyl-L-alanine | Boc-β-cyclohexyl-L-alanine, is an Alanine derivative, that can be used as an intermediate in the synthesis of pharmaceutical and biologically active compounds, including inhibitors. It is used in the synthesis of a novel class of piperidine or morpholine-based renin inhibitors, and also for the preparation of Remikiren. Synonyms: Boc-L-Cha-OH; Boc-3-cyclohexyl-L-alanine; (S)-2-tert-Butoxycarbonylamino-3-cyclohexyl-propionic acid; Boc-Cha-OH; BOC-BETA-CYCLOHEXYL-ALA-OH; Boc-L-cyclohexylalanine; (S)-2-(tert-butoxycarbonylamino)-3-cyclohexylpropanoic acid; Cyclohexanepropanoic acid, a-[[(1,1-dimethylethoxy)carbonyl]amino]-,(aS)-; N-BOC-b-cyclohexylalanine; AK-76930; Boc-3-cyclohexyl-L-alanine; N-BOC-beta-cyclohexylalanine; Boc L Cha OH. Grade: 99%. CAS No. 37736-82-6. Molecular formula: C14H25NO4. Mole weight: 271.35. | |
| Brain natriuretic peptide (1-32) (human) | An agonist at atrial natriuretic peptide (ANP) receptor A (NRP1) which is secreted from cardiac ventricles in response to volume increase and pressure overload. It exhibits natriuretic, vasodilatory and lusitropic activity and suppresses sympathetic and renin-angiotensin-aldosterone systems in vivo, and decreases de novo collagen synthesis as well as increases MMP gene expression in vitro. Synonyms: Brain Natriuretic Peptide-32 human; BNP-32 (human); Nesiritide; H-Ser-Pro-Lys-Met-Val-Gln-Gly-Ser-Gly-Cys(1)-Phe-Gly-Arg-Lys-Met-Asp-Arg-Ile-Ser-Ser-Ser-Ser-Gly-Leu-Gly-Cys(1)-Lys-Val-Leu-Arg-Arg-His-OH; L-seryl-L-prolyl-L-lysyl-L-methionyl-L-valyl-L-glutaminyl-glycyl-L-seryl-glycyl-L-cysteinyl-L-phenylalanyl-glycyl-L-arginyl-L-lysyl-L-methionyl-L-alpha-aspartyl-L-arginyl-L-isoleucyl-L-seryl-L-seryl-L-seryl-L-seryl-glycyl-L-leucyl-glycyl-L-cysteinyl-L-lysyl-L-valyl-L-leucyl-L-arginyl-L-arginyl-L-histidine (10->26)-disulfide. Grade: ≥99% by HPLC. CAS No. 124584-08-3. Molecular formula: C143H244N50O42S4. Mole weight: 3464.04. | |
| Cgp 29287 | Cgp 29287 is a renin inhibitor with a prolonged duration of action. Synonyms: CGP-29287; Z-Arg-Arg-Pro-Phe-His-Sta-Ile-His-Nepsilon-Boc-Lys methyl ester. Grade: 95%. CAS No. 93287-54-8. Molecular formula: C72H110N20O15. Mole weight: 1495.77. | |
| Cgp 38560 | Cgp 38560 is a potent renin inhibitor and it can induce a dose-dependent decrease in angiotensin II and plasma renin activity and a long-lasting and dose-dependent rise in active renin. Although reduction of plasma renin activity to unmeasurable levels, the doses used did not reduce plasma angiotensin II maximally. Synonyms: Cgp 38560; Cgp38560; Cgp-38560. (R)-N-(2-(((1,1-dimethylethyl)sulfonyl)methyl)-1-oxo-3-phenylpropyl)-L-histidyl-3-cyclohexyl-L-alanyl-N-butyl-L-Valinamide monomethanesulfonate. Grade: 98%. CAS No. 122088-76-0. Molecular formula: C39H64N6O9S2. Mole weight: 825.09. | |
| chymosin | Neonatal gastric enzyme with high milk clotting and weak general proteolytic activity, formed from prochymosin. Found among mammals with postnatal uptake of immunoglobulins. In peptidase family A1(pepsin A family). Group: Enzymes. Synonyms: rennin (but this should be avoided since it leads to confusion with renin). Enzyme Commission Number: EC 3.4.23.4. CAS No. 9001-98-3. Rennin. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4276; chymosin; EC 3.4.23.4; 9001-98-3; rennin (but this should be avoided since it leads to confusion with renin). Cat No: EXWM-4276. | |
| CI 992 | CI 992 is a renin inhibitor originated by Pfizer. Preclinical trials for Hypertension in USA was discontinued in 1994. Uses: Hypertension. Synonyms: CI 992; CI992; CI-992. N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[(1S,2R,3S)-1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide; [1S-(1R*,2S*,3R*)]- N-(4-morpholinylsulfonyl)-L-phenylalanyl-3-(2-amino-4-thiazolyl)-N-[1-(cyclohexylmethyl)-2,3-dihydroxy-5-methylhexyl]-L-alaninamide; PD 134672; PD134672; PD-134672. Grade: 98%. CAS No. 135704-06-2. Molecular formula: C33H52N6O7S2. Mole weight: 708.94. | |
| CP-71362 | CP-71362 is a pentapeptide renin inhibitor. It is selective for the canine enzyme. Synonyms: CP 71362; CP71362; CP-71362. L-Phenylalanine, N-(N2-(6-cyclohexyl-5-((N-(N-((1,1-dimethylethoxy)carbonyl)-L-phenylalanyl)-L-histidyl)amino)-4-hydroxy-2-(2-methylpropyl)-1-oxohexyl)-L-lysyl)-, (2R-(2R*,4S*,5S*))-. Grade: >98%. CAS No. 112227-15-3. Molecular formula: C51H76N8O9. Mole weight: 945.20. | |
| CP 81282 | CP 81282 shows human renin and endothiapepsin inhibitory efficacy, but no detailed data has been published yet. Synonyms: CP 81282; CP81282; CP-81282; CP-81,282. (S)-N-(4-morpholinylcarbonyl)-L-phenylalanyl-N-(1-(cyclohexylmethyl)-3,3-difluoro-4-(methylamino)-2,4-dioxobutyl)-L-Norleucinamide. Grade: 98%. CAS No. 121584-61-0. Molecular formula: C32H47F2N5O6. Mole weight: 635.74. | |
| CP 84364 | CP 84364 is an active metabolite of CP-80794 which is a Renin inhibitor. Synonyms: CP 84364; CP84364; CP84364; CP 84,364. 4-Cyclohexyl-2-hydroxy-3-(3-methylsulfanyl-2-(2-((morpholine-4-carbonyl)amino)-3-phenylpropionylamino)propionylamino)butyric acid. Grade: 98%. CAS No. 114457-62-4. Molecular formula: C14H18N2O4. Mole weight: 278.31. | |
| Cyclothiazomycin | It is produced by the strain of Streptomyces sp. NR0516. It selectively inhibits renin activity and does not inhibit pepsin, aspartic acid, serine, mercaptan protease and metalloproteinases. In addition, it has weak antifungal activity. Synonyms: cyclothiazomycin A; 5102-II. CAS No. 133352-26-8. Molecular formula: C59H64N18O14S7. Mole weight: 1473.71. | |
| Enalkiren | Enalkiren: Introducing Enalkiren is an efficacious and exclusive suppressor of human renin, a pivotal enzyme within the renin-angiotensin-aldosterone system. Its indispensable role lies in studying hypertension (increased blood pressure) and congestive heart failure. Uses: Protease inhibitors. Synonyms: Enalquireno; Enalkirene; 3-amino-N-[(2S)-1-[[(2S)-1-[[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino]-3-(1H-imidazol-5-yl)-1-oxopropan-2-yl]amino]-3-(4-methoxyphenyl)-1-oxopropan-2-yl]-3-methylbutanamide. CAS No. 113082-98-7. Molecular formula: C35H56N6O6. Mole weight: 656.86. | |
| H-Lys-Phe-OH. HCl | H-Lys-Phe-OH exerts a remarkable ACE- and renin-inhibitory activity. Synonyms: L-Lysyl-L-phenylalanine hydrochloride. CAS No. 4078-58-4. Molecular formula: C15H24ClN3O3. Mole weight: 329.82. | |
| Losartan Carboxylic Acid | Losartan Carboxylic Acid (E-3174), an active carboxylic acid metabolite of Losartan, is an angiotensin II receptor type 1 (AT1) antagonist. The Ki values are 0.97, 0.57, 0.67 nM for rat AT1B/AT1A and human AT1, respectively. Losartan Carboxylic Acid blocks the angiotensin II-induced responses in vascular smoothmuscle cells (VSMC). Losartan Carboxylic Acid elevates plasma renin activities and reduces mean arterial pressure[1][2][3][4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: E-3174; EXP-3174. CAS No. 124750-92-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12765. | |
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