A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Taq DNA Polymerase. Taq dna polymerase is purified from e. coli expressing a cloned dna polymerase from thermus aquaticus. the enzyme consists of a single polypeptide with a molecular weight of approximately 94 kda. taq dna polymerase has 5?-3? dna polymerase activity and 5?-3? exonuclease activity. it lacks 3?-5? exonuclease activity. taq dna polymerase is suitable for routine amplification. pcr products are unsuitable for page. extension rate is about 1-2 kb/min. template-independent a can be generated at the 3? end of the pcr product. amplification of genomic dna fragment up to 4 kb. Group: Cloning Enzymes. Purity: 500U; 2500U. Storage: Store at -20 ?. Cat No: CE-3003.
Taq I
One unit of the enzyme is the amount required to hydrolyze 1 μg of Lambda DNA in 1 hour at 65°C in a total reaction volume of 50 μl. Applications: After 20-fold overdigestion with enzyme more than 95% of the dna fragments can be ligated and recut. Group: Restriction Enzymes. Purity: 2000U; 10000U. T↑CGA AGC↓T. Activity: 20000u.a./ml. Appearance: 10 X SE-buffer Y, BSA. Storage: -20°C. Form: Liquid. Source: An E.coli strain, that carries the cloned gene Taq I from Thermus aquaticus. Pack: 10 mM Tris-HCl (pH 7.5); 300 mM NaCl; 0,1 mM EDTA; 1 mM DTT; 200 μg/ml BSA; 50% glycerol. Cat No: ET-1182RE.
Tarafenacin
Tarafenacin is a highly selective M3 muscarinic receptor antagonist. It was the most potent in inhibiting carbachol-induced bladder contractions of the anti-cholinergic agents tested, without affecting atrial contractions over the same range of concentrations. Synonyms: SVT-40776, SVT 40776, SVT40776, Tarafenacin. Grades: >98%. CAS No. 385367-47-5. Molecular formula: C21H20F4N2O2. Mole weight: 408.39.
Tarafenacin D-tartrate
Tarafenacin is a highly selective M3 muscarinic receptor antagonist (Ki=0.19 nM), ~200 fold selectivity over M2 receptor. Synonyms: SVT-40776; SVT 40776; SVT40776; Tarafenacin (D-tartrate); Tarafenacin D-tartrate; Tarafenacin D tartrate; Tarafenacin Dtartrate; Tarafenacin-D-tartrate. Grades: >98%. CAS No. 1159101-48-0. Molecular formula: C25H26F4N2O8. Mole weight: 558.48.
Tara gallotannin
. CAS No. 1404-55-4. Product ID: 2-08174. Molecular formula: C27H24O18. Mole weight: 636.48. Purity: based on quinic acid, tannic acid >93% (db). Source : from Caesalpinia spinosa.
Tara gallotannin
. CAS No. 1404-55-4. Product ID: 2-08173. Molecular formula: C27H24O18. Mole weight: 636.48. Purity: >95% (db). Properties: based on quinic acid, tannic acid. Source : from Caesalpinia spinosa.
Tara gum
Tara gum is a galactomannan derived from the seeds of the tara shrub Caesalpinia spinosa, which is native to northern Africa and South America. The gum is described as having a backbone of (1-4)-linked β-D-mannopyranosyl units one third of which possess a single unit side chain of (1-6)-linked α-D-galactopyranose. It forms gels with carrageenan and xanthan in a similar way to guar gum and locust bean gum. Currently, only a small amount of tara gum is used as a food thickener and stabilizer. CAS No. 39300-88-4.
Tara Gum
galactomannan from Caesalpinia spinosa (1-6) linked α-D-galactopyranose units on linear (1-4)-ß-D-mannopyranose units. CAS No. 39300-88-4. Product ID: 4-00694.
Tara Gum
Tara Gum. CAS No. 39300-88-4. Kosher: Y. VIGON Item # 507894. Categories: Speciality Ingrdients Suppliers, Cosmetics, Aromatherapy, Essetial Oils.
America & Internationally
Taranabant
Taranabant is a cannabinoid 1 receptor inverse agonist ( IC50 =0.3 nM). Uses: A cannabinoid 1 receptor inverse agonist. Synonyms: MK-0364, MK 0364, MK0364, Taranabant. N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide;N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-[(5-(trifluoromethyl)pyridin-2-yl)oxy]propanamide. Grades: ≥95%. CAS No. 701977-09-5. Molecular formula: C27H25ClF3N3O2. Mole weight: 515.95.
Taraxasterol
Taraxasterol is a pentacyclic triterpenoid compound isolated from Taraxacum mongolicum. Taraxasterol is an LXRα activator, with metabolic and anti-inflammatory effects. Taraxasterol may be used in research on immune-inflammatory diseases [1] [2] [3]. Uses: Scientific research. Group: Natural products. CAS No. 1059-14-9. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N1178.
Taraxasteryl acetate
Taraxasteryl acetate is isolated from P. sagittalis ,and has a broad spectrum of anti-inflammatory activity. Taraxasterol acetate promotes RNF31 degradation by activating autophagy. Taraxasteryl acetate relieves dextran, zymosan and arachidonic acid induced rat hind-paw edema. Taraxasteryl acetate can be used for the topical inflammation treatment [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 6426-43-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2478.
Taraxasteryl acetate
Taraxasteryl acetate. Group: Biochemicals. Alternative Names: Lactucone; Lactucerin. Grades: Plant Grade. CAS No. 6426-43-3. Pack Sizes: 10mg. Molecular Formula: C32H52O2, Molecular Weight: 468.754. US Biological Life Sciences.
Worldwide
Taraxerol
Taraxerol is isolated from Taraxacum mongolicum , and has anti-inflammtory and anti-cancer effects. Taraxerol attenuates acute inlammation through inhibition of NF-κB signaling pathway. Taraxerol induces cell apoptosis [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 127-22-0. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N2477.
taraxerol synthase
The enzyme gives taraxerol, β-amyrin and lupeol in the ratio 70:17:13. Group: Enzymes. Synonyms: RsM2; (S)-2,3-epoxysqualene mutase (cyclizing, taraxerol-forming). Enzyme Commission Number: EC 5.4.99.35. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5576; taraxerol synthase; EC 5.4.99.35; RsM2; (S)-2,3-epoxysqualene mutase (cyclizing, taraxerol-forming). Cat No: EXWM-5576.
Taraxerone
Taraxerone is isolated from Sedum sarmentosum. Taraxerone enhances effects on alcohol dehydrogenase ( ADH ) and acetaldehyde dehydrogenase ( ALDH ) activities with EC 50 values of 512.42 and 500.16 μM, respectively [1]. Uses: Scientific research. Group: Natural products. CAS No. 514-07-8. Pack Sizes: 1 mg; 5 mg. Product ID: HY-N1177.
Tarcocimab
Tarcocimab (OG1953) is a humanized anti- VEGFA monoclonal antibody (IgG1 type). Tarcocimab is available for research in retinal vein occlusion (RVO) and wet age-related macular degeneration (AMD). Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: OG1953. CAS No. 2408661-40-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99576.
Tarenflurbil
Tarenflurbil ((R)-Flurbiprofen) is the R-enantiomer of the racemate NSAID Flurbiprofen, Tarenflurbil ((R)-Flurbiprofen) inhibits the binding of [ 3 H]9-cis-RA to RXRα LBD with IC 50 of 75 μM. Tarenflurbil can be used for Alzheimer's disease research. Uses: Scientific research. Group: Signaling pathways. Alternative Names: (R)-Flurbiprofen; MPC7869. CAS No. 51543-40-9. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-10291.
Tarextumab
Tarextumab (OMP-59R5) is an anti- Notch2/3 fully human IgG2 monoclonal antibody. Tarextumab shows anti-tumor activity [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody. CAS No. 1359940-55-8. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99320.
Targeted Therapy Drug Library
116 tumor-targeted drugs that can be used for high-throughput and high-content screening. - Targets include EGFR, VEGFR, c-Met, Bcr-Abl, HER2, etc. - All compounds have known and good biological activity, safety and bioavailability. - Detailed instructions, compound structures, target information, IC50 values, activity descriptions, etc. - Various detection techniques such as NMR, HPLC/LCMS to ensure correct structure, high purity and reduce the false-positive rates. Uses: Scientific use. Product Category: L2152. Categories: Targeted Therapy Drug Libraries.
Target-Focused Phenotypic Screening Library
A unique collection of 1832 annotated bioactive compounds with clear targets, suitable for phenotypic screening?- Cover more than 600 drug targets, Structurally diverse?- 2-4 structurally diversified compounds for the same annotated 'on-target' to increase the success rate of target identification (enables the generation of much stronger target-phenotype hypotheses); - Detailed information about compound structure, target, activity, etc. ?- NMR and HPLC/LCMS validated to ensure high purity and quality. Uses: Scientific use. Product Category: L9500. Categories: Target-Focused Phenotypic Screening Libraries.
Taribavirin
Taribavirin is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin, is a ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 119567-79-2. Molecular formula: C8H13N5O4. Mole weight: 243.2217. Canonical SMILES: N=C(C1=NN([C@H]2[C@@H]([C@@H]([C@@H](CO)O2)O)O)C=N1)N. Product ID: ACM119567792. Alfa Chemistry ISO 9001:2015 Certified.
Taribavirin hydrochloride
Taribavirin hydrochloride is an orally active inosine monophosphate dehydrogenase inhibitor, has activity against a wide range of viruses, especially the hepatitis C virus and influenza virus. Taribavirin hydrochloride is a Ribavirin proagent, is designed to concentrate within the liver to target HCV-infected hepatocytes while minimizing distribution within red blood cells (RBCs) and the development of hemolytic anemia [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 40372-00-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10545A.
Tariquidar, also known as XR9576, is a P-glycoprotein inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity. Synonyms: XR 9576; XR9576; XR-9576; D06008. Grades: >98%. CAS No. 206873-63-4. Molecular formula: C38H38N4O6. Mole weight: 646.744.
Tariquidar
Tariquidar. Uses: Designed for use in research and industrial production. CAS No. 206873-63-4. Molecular formula: C38H38N4O6. Mole weight: 646.73. Purity: 0.98. Product ID: ACM206873634. Alfa Chemistry ISO 9001:2015 Certified.
Tariquidar dihydrochloride is a potent P-glycoprotein (P-gp) inhibitor (IC50 = 5.1 nM). Tariquidar was found to reverse drug resistance in multiple MDR cell lines. Tariquidar binds to the p-glycoprotein transporter, and inhibits transmembrane transport of anticancer drugs, leading to increased concentrations and enhanced cytotoxic effects of anticancer drugs. Synonyms: N-[2-[[[4-[2- (3, 4-dihydro-6, 7-dimethoxy-2 (1H) -isoquinolinyl) ethyl]phenyl]amino]carbonyl]-4, 5-dimethoxyphenyl]-3-quinolinecarbxamide dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1992047-62-7. Molecular formula: C38H38N4O6.2HCl. Mole weight: 719.66.
Tariquidar methanesulfonate hydrate
Tariquidar methanesulfonate is a potent and selective noncompetitive inhibitor of P-glycoprotein(Kd =5.1 nM). Uses: P-glycoprotein inhibitor, potent and selective. Synonyms: XR 9576; XR9576; XR-9576;N-[2-[[4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)ethyl]phenyl]carbamoyl]-4,5-dimethoxyphenyl]quinoline-3-carboxamide;methanesulfonic acid;trihydrate. Grades: ≥98%. CAS No. 625375-83-9. Molecular formula: C40H52N4O15S2. Mole weight: 892.99.
Tarlatamab
Tarlatamab (AMG-757) is a bispecific T-cell engager (BiTE) antibody targeting delta-like ligand 3 (DLL3). DLL3 is a target that is selectively expressed in small-cell lung cancer (SCLC) tumors, but with minimal normal tissue expression. Tarlatamab has the K D s of 0.64 nM and 0.50 nM for human and nonhuman primate (NHP) DLL3, respectively. Tarlatamab has the K D s of 14.9 nM and 12 nM for human and NHP CD3, respectively. Tarlatamab is a first-in-class HLE BiTE immuno-oncology therapy targeting DLL3 and has the potential for SCLC research [1]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: AMG-757. CAS No. 2307488-83-9. Pack Sizes: 1 mg; 5 mg. Product ID: HY-P99575.
Tarloxotinib bromide
Tarloxotinib bromide, a pyridopyrimidine derivative, has been found to be a EGFR tyrosine kinase inhibitor precursor and could probably be effective in antineoplastic researches. Synonyms: Tarloxotinib bromide; Tarloxotinib bromide [INN]; SCHEMBL11902818; SCHEMBL17873943; [(E)-4-[[4-(3-bromo-4-chloroanilino)pyrido[3,4-d]pyrimidin-6-yl]amino]-4-oxobut-2-enyl]-dimethyl-[(3-methyl-5-nitroimidazol-4-yl)methyl]azanium;bromide. Grades: 98%. CAS No. 1636180-98-7. Molecular formula: C24H24Br2ClN9O3. Mole weight: 681.77.
Tarloxotinib bromide
Tarloxotinib bromide (TH-4000) is an irreversible EGFR/HER2 inhibitor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TH-4000. CAS No. 1636180-98-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17632.
TARTARIC ACID, L, ACS Reagent, powder, (Synonym: 2,3-Dihydroxybutanedioic Acid), Formula: HO2CCH(OH)CH(OH)CO2H. CAS No. 87-69-4. Noah Chemicals San Antonio, Texas. ISO 9001:2015 Certified. Request a Quote Today!
Texas TX
Tartaric Acid
Tartaric acid occurs as colorless monoclinic crystals, or a white or almost white crystalline powder. It is odorless, with an extremely tart taste. Synonyms: Acidum tartaricum; L-(+)-2 , 3-dihydroxybutanedioic acid; (2R, 3R)- dihydroxybutane-1, 4-dioic acid; d- tartaric acid; 2 , 3-dihydroxysuccinic acid; L-(+)- tartaric acid. CAS No. 87-69-4. Product ID: PE-0449. Molecular formula: C4H6O6. Mole weight: 150.09. Category: Effervescents. Product Keywords: Pharmaceutical Excipients; Excipients for Liquid Dosage Form; Tartaric Acid; Effervescents; Effervescents; C4H6O6; 87-69-4; 87-69-4. UNII: W4888I119H. Chemical Name: (2R, 3R)-2, 3-Dihydroxybutanedioic acid. Administration route: IM and IV; oral; sublingual; topical; rectal and vaginal. Dosage Form: IM and IV injections; oral solutions, syrups and tablets; sublingual tablets; topical films; rectal and vaginal preparations. Stability and Storage Conditions: The bulk material is stable and should be stored in a well-closed container in a cool, dry place. Source and Preparation: Tartaric acid occurs naturally in many fruits as the free acid or in combination with calcium, magnesium, and potassium. Commercially, L-(+)-tartaric acid is manufactured from potassium tartrate (cream of tartar), a by-product of wine making.Potassium tartrate is treated with hydrochloric acid, followed by the addition of a calcium salt to produce insoluble calcium tartrate. This precipitate is th
Tartaric Acid 87-69-4
Tartaric Acid - Surface Coatings. SUPPLIERS TO BUSINESS CUSTOMERS ONLY.
North America & APAC
Tartaric acid aq. solution
Tartaric acid aq. solution. Group: Acids and alkalis. CAS No. 87-69-4.
Tartaric Acid BP/USP
Tartaric Acid BP/USP. CAS No. 87-69-4. Molecular formula: C4H6O6.
Tartaric Acid, Granular, NF
L-(+)-Tartaric Acid; 2,3-Dihydroxybutanedioic Acid. cationic transfection agent, bile acid sequestrant, vaccine adjuvant, protein stabilizer. Grades: NF. CAS No. 87-69-4. Product ID: 8-01600. Molecular formula: C4H6O6. Mole weight: 150.09 . Reference: Other molecular weights available. Please inquire.
Tartaric Acid Impurity 1
Tartaric Acid Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 3333-46-8. Molecular Formula: C5H8O6. Mole Weight: 164.11. Catalog: APB3333468.
Tartaric Acid Impurity 2
Tartaric Acid Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 133-37-9. Molecular Formula: C4H6O6. Mole Weight: 150.09. Catalog: APB133379.
Tartaric Acid Impurity 3
Tartaric Acid Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 60908-35-2. Molecular Formula: C10H10N2O7. Mole Weight: 270.2. Catalog: APB60908352.
Tartaric Acid Impurity 4
Tartaric Acid Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 391624-79-6. Molecular Formula: C20H18O10. Mole Weight: 418.35. Catalog: APB391624796.
Tartaric Acid Methyl Ester
Tartaric Acid Methyl Ester is useful for developing stabilizers as additives in methanol-gasoline. In addition, Tartaric Acid Methyl Ester can be used to synthesize novel enantiopure γ/δ-amino acid via trans-acetalization. Group: Biochemicals. Grades: Highly Purified. CAS No. 3333-46-8. Pack Sizes: 100mg, 250mg. Molecular Formula: C5H8O6. US Biological Life Sciences.
Worldwide
Tartary Buckwheat Extract
Tartary Buckwheat Extract. Applications: Used for health care products, dietary supplements, reduce blood press, antioxidant. Group: Others. Synonyms: Tartary Buckwheat Extract; Fagopyrum tataricum (L.) Gaertn. Purity: 30%-70% Total Flavonoid By UV. Appearance: Yellow green fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Fruit. Species: Fagopyrum tataricum (L.) Gaertn. Tartary Buckwheat Extract; Fagopyrum tataricum (L.) Gaertn; plant extract. Pack: 20KG-25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-099.
Tart Cherry Fruit Powder & 4:1
Tart Cherry Fruit Powder & 4:1.
CA, FL & NJ
tartrate decarboxylase
This enzyme belongs to the family of lyases, specifically the carboxy-lyases, which cleave carbon-carbon bonds. Group: Enzymes. Synonyms: (R,R)-tartrate carboxy-lyase. Enzyme Commission Number: EC 4.1.1.73. CAS No. 124248-30-2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4821; tartrate decarboxylase; EC 4.1.1.73; 124248-30-2; (R,R)-tartrate carboxy-lyase. Cat No: EXWM-4821.
tartrate dehydrogenase
meso-tartrate and (R,R)-tartrate act as substrates. Requires Mn2+ and a monovalent cation. Group: Enzymes. Synonyms: mesotartrate dehydrogenase. Enzyme Commission Number: EC 1.1.1.93. CAS No. 37250-29-6. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0377; tartrate dehydrogenase; EC 1.1.1.93; 37250-29-6; mesotartrate dehydrogenase. Cat No: EXWM-0377.
tartrate epimerase
This enzyme belongs to the family of isomerases, specifically those racemases and epimerases acting on hydroxy acids and derivatives. This enzyme participates in glyoxylate and dicarboxylate metabolism. Group: Enzymes. Synonyms: tartaric racemase. Enzyme Commission Number: EC 5.1.2.5. CAS No. 37318-33-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5392; tartrate epimerase; EC 5.1.2.5; 37318-33-5; tartaric racemase. Cat No: EXWM-5392.
Tartrazine, a kind of azo dye, could also be used in pharmaceuticals and has been found to cause allergic and intolerance reactions in patients with asthmatics. Synonyms: Acid Yellow 23; 4,5-Dihydro-5-oxo-1-(4-sulfophenyl)-4-[2-(4-sulfophenyl)diazenyl]-1H-pyrazole-3-carboxylic Acid Sodium Salt; Aizen Tartrazine; Vondacid Tartrazine; Wool Yellow. Grades: >95%. CAS No. 1934-21-0. Molecular formula: C16H9N4Na3O9S2. Mole weight: 534.37.
Tartrazine
Tartrazine. Group: Biochemicals. Alternative Names: 4,5-Dihydro-5-oxo-1-(4-sulfophenyl)-4-[2-(4-sulfophenyl)diazenyl]-1H-pyrazole-3-carboxylic acid sodium salt; Aizen tartrazine; Acid yellow 23. Grades: Highly Purified. CAS No. 1934-21-0. Pack Sizes: 100g, 250g, 500g, 1Kg, 2Kg. Molecular Formula: C16H9N4Na3O9S2. US Biological Life Sciences.
Worldwide
Tartrazine
Tartrazine (Acid Yellow 23; FD&C Yellow No. 5) is an orally active azo acid dye, orange-yellow powder, soluble in water and turns yellow. Tartrazine is mainly used as a synthetic lemon yellow azo dye for food coloring. Tartrazine is the most stable colorant.Tartrazine induces mitochondria-mediated Apoptosis. Tartrazine can cause neurodevelopmental toxicity, cytotoxicity, and genotoxicity [1] [2] [3] [4] [5] [6] [7] [8] [9] [10] [11]. Uses: Scientific research. Group: Fluorescent dye. Alternative Names: Acid Yellow 23; FD&C Yellow No. 5. CAS No. 1934-21-0. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g. Product ID: HY-D0257.
Tartrazine ≥85% (Dye content)
Tartrazine ≥85% (Dye content). Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 100g, 500g. US Biological Life Sciences.
Worldwide
tartronate O-hydroxycinnamoyltransferase
4-Coumaroyl-CoA (4-hydroxycinnamoyl-CoA), caffeoyl-CoA (3,4-dihydroxycinnamoyl-CoA) and feruloyl-CoA (4-hydroxy-3-methoxycinnamoyl-CoA) can also act as donors for the enzyme from the mung bean (Vigna radiata). Group: Enzymes. Synonyms: tartronate sinapoyltransferase; hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase. Enzyme Commission Number: EC 2.3.1.106. CAS No. 102484-57-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2044; tartronate O-hydroxycinnamoyltransferase; EC 2.3.1.106; 102484-57-1; tartronate sinapoyltransferase; hydroxycinnamoyl-coenzyme-A:tartronate hydroxycinnamoyltransferase. Cat No: EXWM-2044.
tartronate-semialdehyde synthase
A flavoprotein. Group: Enzymes. Synonyms: tartronate semialdehyde carboxylase; glyoxylate carbo-ligase; glyoxylic carbo-ligase; hydroxymalonic semialdehyde carboxylase; tartronic semialdehyde carboxylase; glyoxalate carboligase; glyoxylate carboxy-lyase (dimerizing); glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming). Enzyme Commission Number: EC 4.1.1.47. CAS No. 9027-24-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4792; tartronate-semialdehyde synthase; EC 4.1.1.47; 9027-24-1; tartronate semialdehyde carboxylase; glyoxylate carbo-ligase; glyoxylic carbo-ligase; hydroxymalonic semialdehyde carboxylase; tartronic semialdehyde carboxylase; glyoxalate carboligase; glyoxylate carboxy-lyase (dimerizing); glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming). Cat No: EXWM-4792.
TAS0728 is a potent and seletive HER2 inhibitor possibly used for the treatment of various cancers. It covalently binds to HER2 at C805 and selectively inhibits its kinase activity. Synonyms: (R)-1-(1-acryloylpiperidin-3-yl)-4-amino-N-(4-(2-(dimethylamino)-2-oxoethyl)-2,3-dimethylphenyl)-1H-pyrazolo[3,4-d]pyrimidine-3-carboxamide. CAS No. 2088323-16-2. Molecular formula: C26H32N8O3. Mole weight: 504.6.
TAS-102
TAS-102 is a combination drug composed of the cytotoxic pyrimidine analog Trifluridine (5-trifluoro-2'-deoxythymidine or TFT) and a thymidine phosphorylase inhibitor (TPI) tipiracil hydrochloride, in a molar ratio of 1.0:0.5 (TFT:TPI). TAS-102 is used as a third- or fourth-line treatment of metastatic colorectal cancer. Synonyms: Tipiracil / Trifluridine; Viroptic mixture with 5-CIMU; TAS 102; EX-A1755; Tipiracil hydrochloride / Trifluridine. CAS No. 733030-01-8. Molecular formula: C9H11ClN4O2·HCl·C10H11F3N2O5. Mole weight: 575.328.
TAS-103
TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. TAS-103 may be useful in the chemotherapy of colorectal cancer. Uses: Topoisomerase i inhibitors. Synonyms: BMS-247615; TAS103; TAS 103; BMS247615; BMS 247615. Grades:>98%. CAS No. 174634-08-3. Molecular formula: C20H19N3O2. Mole weight: 333.38.
TAS-103 dihydrochloride
TAS-103, also known as BMS-247615, is a quinoline derivative that displays antitumor activity in murine and human tumor models. TAS-103 has been reported to be a potent topoisomerase II poison. TAS-103 showed the strongest antitumor activity among the conventional anticancer agents for colorectal cancer (p<0.05). The combination with CDDP augmented the antitumor activity of TAS-103 (p<0.05), indicating that CDDP is one of the most potent candidates to be used in combination with TAS-103. Synonyms: 6-((2-(dimethylamino)ethyl)amino)-3-hydroxy-7H-indeno[2,1-c]quinolin-7-one dihydrochloride; TAS103; TAS-103; TAS 103; BMS247615; BMS 247615; BMS-247615. Grades:>98%. CAS No. 174634-09-4. Molecular formula: C20H21Cl2N3O2. Mole weight: 406.31.
TAS-108
TAS-108, also known as SR16234, is a synthetic, antiestrogenic steroidal compound with potential antitumor activity. TAS-108 binds to and inhibits estrogenic receptor alpha (ERa), mainly expressed in the mammary gland and uterus and upregulated in estrogen-dependent tumors. Blockage of ERa by TAS-108 prevents the binding and effects of estrogen and may lead to an inhibition of estrogen-dependent cancer cell proliferation. TAS-108 also is a partial agonist of the estrogenic receptor beta (ERb), expressed in many tissues including the central nervous system, urogenital tract, bone and cardiovascular system, thereby exerting a positive effect on these tissues. In addition, TAS-108 activates the co-repressor Silencing Mediator for Retinoid and Thyroid hormone receptor (SMRT), a protein that inhibits the activities of the estrogen receptors, which may contribute to the antitumor activity of TAS-108. Synonyms: TAS108; TAS 108; SR16234; SR 16234; SR-16234; (7alpha)-21-(4-((Diethylamino)methyl)-2-methoxyphenoxy)-7-methyl-19-norpregna-1,3,5(10)-trien-3-ol 2-hydroxy-1,2,3-propanetricarboxylate. Grades: >98%. CAS No. 229634-98-4. Molecular formula: C39H55NO10. Mole weight: 697.86.
TAS-115
This active molecular is a c-MET and VEGFR inhibitor which is selective and specific in vitro. In vivo studies, TAS-115 suppressed the progression of MET-inactivated tumor completely through blocking angiogenesis without toxicity and it also induced marked tumor shrinkage and prolonged survival in animal model. In Dec 2013, Phase-I development was ongoing in Japan. In Dec 2014, Taiho Pharmaceutical completed a phase I trial for Solid tumours in Japan. In Apr 2016, preclinical data was presented. Uses: Solid tumours. Synonyms: TAS-115; TAS 115; TAS115; 4-(2-fluoro-4-(3-(2-phenylacetyl)thioureido)phenoxy)-7-methoxy-N-methylquinoline-6-carboxamide. Grades: 98%. CAS No. 1190836-34-0. Molecular formula: C27H23FN4O4S. Mole weight: 518.56.
TAS-116
TAS-116 is a inhibitor of Hsp90. It induces significant cytotoxicity in MM cells even in the presence of BMSCs, associates with downregulation of phospho-Akt and phospho-ERK. In addition, neither exogenous IL-6 nor IGF-1 was able to protect against TAS-116. Importantly, TAS-116 did not induce cytotoxicity in BMSCs. TAS-116 enhanced bortezomib-induced cytotoxicity in MM.1S and RPMI-8226 cells, associated with decreased phospho-Akt, phospho-RelA (p65), phospho-IkBa, and phospho-IKKα/β; as well as increased CHOP and PARP cleavage. These results suggest that TAS-116 blocks bortezomib-induced canonical NF-κB pathway and augments bortezomib-induced endoplasmic reticulum (ER) stress. Synonyms: TAS116; TAS 116; TAS-116; 3-Ethyl-4-[3-(1-methylethyl)-4-[4-(1-methyl-1H-pyrazol-4-yl)-1H-imidazol-1-yl]-1H-pyrazolo[3,4-b]pyridin-1-yl]benzamide. Grades: >98%. CAS No. 1260533-36-5. Molecular formula: C25H26N8O. Mole weight: 454.54.
TAS-119
TAS-119 is a potent, selective and orally active Aurora A inhibitor with an IC 50 of 1.0 nM. TAS-119 shows high selectivity for Aurora A over other protein kinases, including Aurora B ( IC 50 of 95 nM). TAS-119 has potent antitumor activites [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1453099-83-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-137377.
TAS 301
TAS 301. Group: Biochemicals. Grades: Purified. CAS No. 193620-69-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
TAS-301
TAS-301 is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS-103 inhibits smooth muscle cell migration and proliferation. Synonyms: TAS-301; TAS301; TAS301. Grades: 98%. CAS No. 193620-69-8. Molecular formula: C23H19NO3. Mole weight: 357.41.