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One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 2,3. CAS No. 106881-35-0. Molecular formula: C12H19N3O8S. Mole weight: 365.36.
Topiramate Impurity 10
Topiramate Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 35405-70-0. Molecular Formula: C24H39NO13S. Mole Weight: 581.63. Catalog: APB35405700.
Topiramate Impurity 12
Topiramate Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 106881-42-9. Molecular Formula: C6H13NO8S. Mole Weight: 259.23. Catalog: APB106881429.
Topiramate Impurity 14
Topiramate Impurity 14. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (3aR,6R,7S,7aS)-6-(hydroxymethyl)-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-6,7-diol. CAS No. 912456-61-2. Molecular Formula: C9H16O6. Mole Weight: 220.22. Catalog: APB912456612.
Topiramate Impurity 16
Topiramate Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10489-81-3. Molecular Formula: C6H12O6. Mole Weight: 180.16. Catalog: APB10489813.
Topiramate Impurity 17
Topiramate Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 58238-46-3. Molecular Formula: C9H16O6. Mole Weight: 220.22. Catalog: APB58238463.
Topiramate Impurity 18
Topiramate Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 38029-84-4. Molecular Formula: C6H12O6. Mole Weight: 180.16. Catalog: APB38029844.
Topiramate Impurity 2
One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 4,5-O-(1-Methylethylidene)-b-D-fructopyranose 1-sulfamate. CAS No. 851957-35-2. Molecular formula: C9H17NO8S. Mole weight: 299.30.
Topiramate Impurity 6
Topiramate Impurity 6. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: ((3aR,6R,7S,7aS)-6,7-dihydroxy-2,2-dimethyltetrahydro-3aH-[1,3]dioxolo[4,5-c]pyran-6-yl)methyl sulfamate. CAS No. 851957-35-2. Molecular Formula: C9H17NO8S. Mole Weight: 299.30. Catalog: APB851957352.
Topiramate impurity B
Topiramate Impurity B is a pharmaceutical offering, aiding in anchoring the assessment of quality and purity within topiramate formulations, an eminent remedy for epilepsy research and migraine prophylaxis. Synonyms: Topiramate related compound B.
Topiramate impurity C
One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: (2,2,7,7-tetramethyl-tetrahydro-3aH-bis[1,3]dioxolo[4,5-b:4',5'-d] pyran-3a-yl)methyl sulfurochloridoate. Molecular formula: C12H19ClO8S. Mole weight: 358.79.
Topiramate Impurity D
Cas No. 25018-67-1.
Topiramate N-Methyl Impurity
One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: N-Methyl Topiramate; 2,3:4,5-bis-O-(1-Methylethylidene)-β-D-Fructopyranose 1-(N-Methylsulfamate); 2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose Methylsulfamate. CAS No. 97240-80-7. Molecular formula: C13H23NO8S. Mole weight: 353.39.
Topiramate Related Compound A
One of the impurities of Topiramate, which is a fuctopyranose derivative and has been found to be used as an anticonvulsant agent. Synonyms: 2,3:4,5-Di-O-isopropylidene-β-D-fructopyranose; 2,3:4,5-Bis-O-(1-methylethylidene)-β-D-fructopyranose; USP Topiramate Related Compound A; Diacetonefructose; ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4',5'-d]pyran-3a-yl)methanol. Grades: ≥98%. CAS No. 20880-92-6. Molecular formula: C12H20O6. Mole weight: 260.28.
Topiroxostat
Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC 50 value of 5.3 nM and a K i value of 5.7 nM. Topiroxostat exhibits weak CYP3A4 -inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: FYX-051. CAS No. 577778-58-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14874.
Topiroxostat
Topiroxostat. Uses: For analytical and research use. Group: Impurity standards. CAS No. 577778-58-6. Molecular Formula: C13H8N6. Mole Weight: 248.25. Catalog: APB577778586.
Topiroxostat
Topiroxostat is a novel and potent xanthine oxidoreductase (XOR) inhibitor. Uses: Enzyme inhibitors. Synonyms: FYX051; FYX051; FYX 051; Topiroxostat. trade names Topiloric Uriadec. Grades: >98%. CAS No. 577778-58-6. Molecular formula: C13H8N6. Mole weight: 248.24.
Topiroxostat Impurity 1
Topiroxostat Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2044708-04-3. Molecular Formula: C7H10N6O. Mole Weight: 194.2. Catalog: APB2044708043.
Topiroxostat Impurity 1
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Synonyms: 4-(5-(Pyridin-4-yl)-1,3,4-oxadiazol-2-yl)picolinonitrile; 4-(5-pyridin-4-yl-1,3,4-oxadiazol-2-yl)pyridine-2-carbonitrile; TOPIROXOSTAT IMPURITY 1; DTXSID001166750; 2-Pyridinecarbonitrile, 4-[5-(4-pyridinyl)-1,3,4-oxadiazol-2-yl]-. Molecular formula: C7H10N6O. Mole weight: 194.2.
Topiroxostat Impurity 1
Topiroxostat Impurity 1. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)picolinic acid. CAS No. 2044702-36-3. Molecular Formula: C13H9N5O2. Mole Weight: 267.24. Catalog: APB2044702363.
Topiroxostat Impurity 10
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H8N4O. Mole weight: 248.25.
Topiroxostat Impurity 11
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H6N6O. Mole weight: 274.24.
Topiroxostat Impurity 12
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H9N7O. Mole weight: 291.27.
Topiroxostat Impurity 13
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C14H7N7. Mole weight: 273.26.
Topiroxostat Impurity 2
Topiroxostat Impurity 2. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 4-(3-(pyridin-4-yl)-1H-1,2,4-triazol-5-yl)picolinamide. CAS No. 1992028-94-0. Molecular Formula: C13H10N6O. Mole Weight: 266.26. Catalog: APB1992028940.
Topiroxostat Impurity 2
Topiroxostat Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4329-78-6. Molecular Formula: C12H9N5. Mole Weight: 223.24. Catalog: APB4329786.
Topiroxostat Impurity 2
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C7H8N4O2. Mole weight: 180.17.
Topiroxostat Impurity 3
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C6H7N3O2. Mole weight: 153.14.
Topiroxostat Impurity 3
Topiroxostat Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2044704-74-5. Molecular Formula: C13H7N5O. Mole Weight: 249.23. Catalog: APB2044704745.
Topiroxostat Impurity 4
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C12H9N5O. Mole weight: 239.24.
Topiroxostat Impurity 5
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Synonyms: 4-Amino-3,5-bis(4-pyridyl)-1,2,4-triazole; 4,4'-(4-Amino-4H-1,2,4-triazole-3,5-diyl)di-pyridine; 3,5-Di-4-pyridinyl-4H-1,2,4-triazol-4-amine. CAS No. 38634-05-8. Molecular formula: C13H10N6O. Mole weight: 266.26.
Topiroxostat Impurity 5
Topiroxostat Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 6975-73-1. Molecular Formula: C6H7N3O2. Mole Weight: 153.14. Catalog: APB6975731.
Topiroxostat Impurity 6
Topiroxostat Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 13602-12-5. Molecular Formula: C6H5NO3. Mole Weight: 139.11. Catalog: APB13602125.
Topiroxostat Impurity 6
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C13H9N5O2. Mole weight: 267.25.
Topiroxostat Impurity 7
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C20H2N10. Mole weight: 392.39.
Topiroxostat Impurity 7
Topiroxostat Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 161233-97-2. Molecular Formula: C7H4N2O2. Mole Weight: 148.12. Catalog: APB161233972.
Topiroxostat Impurity 9
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Synonyms: Topiroxostat Impurity 9; 577778-82-6; 4-(5-(2-Cyanopyridin-4-yl)-1H-1,2,4-triazol-3-yl)pyridine 1-oxide; SCHEMBL4678077; 4-[5-(1-hydroxypyridin-4-ylidene)-1,2,4-triazol-3-yl]pyridine-2-carbonitrile. CAS No. 577778-82-6. Molecular formula: C13H8N6O. Mole weight: 264.25.
Topiroxostat Impurity C
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C13H7N5O. Mole weight: 249.23.
Topiroxostat Impurity E
Topiroxostat Impurity E. Uses: For analytical and research use. Group: Impurity standards. CAS No. 94413-64-6. Molecular Formula: C8H6N2O2. Mole Weight: 162.15. Catalog: APB94413646.
Topiroxostat Impurity F
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C12H11N5O2. Mole weight: 257.25.
Topiroxostat Impurity L
One of the impurities of Topiroxostat, which is a xanthine oxidase inhibitor and has been found to be effective in the treatment of gout and hyperuricemia. Molecular formula: C13H8N6O. Mole weight: 264.25.
Topoisomerase I from E. coli, Recombinant
Topoisomerase I relaxes supercoiled DNA molecules. The enzyme initiates transient breakages and rejoins of phosphodiester bonds in superhelical turns of closed-circular DNA. Enzyme activity is independent of right-and left-handed superhelices. Topoisomerase i (e. coli) catalyzes the relaxation of negatively supercoiled dna. topoisomerase i has also been implicated in knotting and unknotting dna and in linking complementary rings of single-stranded dna into double-stranded rings. the intact holoenzyme is a 97 kda protein. Group: Enzymes. Synonyms: Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. TOPO I. Storage: at -20°C. Form: 50 mM KCl, 10 mM Tris-HCl (pH 7.5), 35 mM (NH4)2SO4, 0.1 mM EDTA, 1 mM DTT and 50% glycerol. Source: E. coli. Species: E. coli. Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. Cat No: NATE-1339.
Topoisomerase I from Human, Recombinant
Topoisomerase I relaxes supercoiled DNA molecules. The enzyme initiates transient breakages and rejoins of phosphodiester bonds in superhelical turns of closed-circular DNA. Enzyme activity is independent of right-and left-handed superhelices. Group: Enzymes. Synonyms: Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. TOPO I. Stability: Stable for 3 months undiluted. Storage: Store at -80°C. It is recommended that the enzyme is aliquoted to avoid repeated freeze-thaw cycles. Source: Baculovirus-infected insect cells (Spodoptera frugiperda). Species: Human. Topoisomerase I; EC 5.99.1.2; type I DNA topoisomerase; untwisting enzyme; relaxing enzyme; nicking-closing enzyme; swivelase; ω-protein; deoxyribonucleate topoisomerase; topoisomerase; type I DNA topoisomerase; DNA topoisomerase; TOPO I. Cat No: NATE-1340.
Topoisomerase II-alpha-b (828-836)
Topoisomerase II-alpha-b (828-836) is a peptide derived from Topoisomerase II-alpha-b. Topoisomerase II-alpha is an enzyme that controls and alters the topologic states of DNA during transcription. Human topoisomerase II enzymes are targets for a number of widely used anticancer agents.
Topoisomerase II inhibitor 14
Topoisomerase II inhibitor 14 (compound 2f) is a potent inhibtor of Topoisomerase II, with anticancer activity. Topoisomerase II inhibitor 14 induces apoptosis, and arrests cell cycle at S phase. Topoisomerase II inhibitor 14 exhibits antioxidant effect and decreases the level of GSH, MDA, and NO [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 305343-00-4. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-W278582.
Topoisomerase II Inhibitor (BNS-22)
A potent, 2H-chromen-2-one small molecule inhibitor that is selective for TOP2 (IC50=2.8uM and 0.42uM for TOP2a and TOP2b, respectively). Unlike TOP2 poisons such as etoposide, it does not lead to DNA damage associated with DNA Double-Strand Breaks, as evidenced by the lack of y-H2AX accumulation but instead inhibits kinetoplast DNA decatenation in vitro. This compound affects cell cycle at the M phase and disturbs mitotic spindle formation in HeLa cells at 3-10uM. It also exhibits significant anti-proliferative activities against several human cancer cell lines. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Topopyrone A
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone A selectively inhibits topoisomerase I with the IC50 of 1.22 ng/mL. It also has anti-Gram-positive bacteria activity. Molecular formula: C18H9ClO7. Mole weight: 372.71.
Topopyrone B
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone B selectively inhibits topoisomerase I with the IC50 of 0.15 ng/mL. It also has anti-Gram-positive bacteria activity and it has a strong inhibitory effect on herpes virus, especially varicella zoster virus (VZV). Molecular formula: C18H9ClO7. Mole weight: 372.71.
Topopyrone C
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone C selectively inhibits topoisomerase I with the IC50 of 4.88 ng/mL. It also has anti-Gram-positive bacteria activity. Molecular formula: C18H10O7. Mole weight: 338.27.
Topopyrone D
It is produced by the strain of Phoma sp. BAUA 2861 and Penicillum sp. BAUA 4206. Topopyrone A selectively inhibits topoisomerase I with the IC50 of 19.63 ng/mL. Molecular formula: C18H10O7. Mole weight: 338.27.
Topostatin
Topostatin is originally isolated from Thermomonos pora alba No. 1520. It has inhibitory effects on human tumor cells, and the IC50 of SNB-75 and SNB-78 were 0.4 μmol/L and 7 μmol/L, respectively. Molecular formula: C36H58N4O11S. Mole weight: 754.93.
Topotecan
Topotecan (SKF 104864A; NSC 609669) is an orally active and potent Topoisomerase I inhibitor. Topotecan induces cell cycle arrest in G0/G1 and S phases and promotes apoptosis. Topotecan shows anticancer activity [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SKF 104864A; NSC 609669. CAS No. 123948-87-8. Pack Sizes: 1 mg. Product ID: HY-13768.
One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. Synonyms: (4S)-1-(4-Ethyl-4,9-dihydroxy-6-oxido-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3',4',6,7]indolizino[1,2-b]quinolin-10-yl)-N,N-dimethylmethanamine Oxide. Molecular formula: C23H23N3O7. Mole weight: 453.46.
Topotecan carboxylic acid sodium salt. Group: Biochemicals. Alternative Names: 1-[ (Dimethylamino)methyl]-a-ethyl-9, 11-dihydro-a, 2-dihydroxy-8- (hydroxymethyl)-9-oxo-indolizino[1, 2-b]quinoline-7-acetic acid. Grades: Highly Purified. CAS No. 123949-08-6. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C23H24N3NaO6. US Biological Life Sciences.
Worldwide
Topotecan-d5
Labeled Topotecan. A DNA topoisomerase I inhibitor; semisynthetic analog of Camptothecin. Antineoplastic. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4- (ethyl-d5)-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione; NSC-609669-d5; SKF-104864A-d5; Hycamtin-d5. Grades: Highly Purified. CAS No. 1133355-98-2. Pack Sizes: 1mg. US Biological Life Sciences.
Topotecan-d6 is the deuterium labeled Topotecan. Topotecan (SKF 104864A; NSC 609669) is a Topoisomerase I inhibitor. The IC50 values of Topotecan at 24 h are 2.73±0.25 μM of U251 cells, 2.95±0.23 μM of U87 cells, 5.46±0.41 μM of GSCs-U251 and 5.95 μM of GSCs-U87. Group: Inhibitors. Alternative Names: (4S)-10-[(Dimethylamino-d6)methyl]-4-ethyl-4,9-dihydroxy-1H-pyrano[3',4',6-7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione; NSC-609669-d6; SKF-104864A-d6; Hycamtin-d6. CAS No. 1044904-10-0. Molecular formula: C23H17D6N3O5. Mole weight: 427.48. Appearance: Yellow Solid. Purity: 0.96. IUPACName: Topotecan-d6. Canonical SMILES: CCC1 (C2=C (COC1=O)C (=O)N3CC4=C (C3=C2)N=C5C=CC (=C (C5=C4)CN (C)C)O)O. Catalog: ACM1044904100.
Topotecan-d6
Labelled Topotecan, a DNA topoisomerase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 1044904-10-0. Pack Sizes: 1mg. US Biological Life Sciences.
A DNA topoisomerase inhibitor. Group: Biochemicals. Alternative Names: (4S)-10-[ (Dimethylamino)methyl]-4-ethyl-4, 9-dihydroxy-1H-pyrano[3, 4, 6-7]indolizino[1, 2-b]quinoline-3, 14 (4H, 12H)-dione, Hydrochloride, SKF-104864A. Grades: Highly Purified. CAS No. 119413-54-6. Pack Sizes: 2.5mg. US Biological Life Sciences.
Worldwide
Topotecan Hydrochloride Liposome (PEGylated)
Topotecan Hydrochloride (TPT) is a semi-synthetic derivative of the plant alkaloid camptothecin (CPT) with cytotoxic properties. Like other drugs in the CPT family, TPT is a specific inhibitor of topoisomerase I, causing lethal DNA damage in the S phase of mitosis. Liposome preparation and anti-tumor activity research. This product is a pre-formulated liposome encapsulating Topotecan Hydrochloride. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
Topotecan N-Oxide
One of the impurities of Topotecan, which is a topoisomerase I inhibitor and has been found to be an effective antineoplastic agent. CAS No. 1398723-05-1. Molecular formula: C23H23N3O6. Mole weight: 437.46.
TO-PRO-3 iodide
TO-PRO-3 iodide is a highly efficient blue fluorescent dye that can stain cytoplasm as a cell tracer. Uses: Scientific research. Group: Fluorescent dye. CAS No. 157199-63-8. Pack Sizes: 671 μg (5 mM * 200 μL in DMSO). Product ID: HY-117070.
TOPS
TOPS is a highly water-soluble aniline derivative widely used in diagnostics and biological experiments. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 40567-80-4. Pack Sizes: 10 mM * 1 mL; 500 mg; 1 g; 5 g. Product ID: HY-15933.