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| Product | Description | |
|---|---|---|
| Tcpobop | TCPOBOP is a constitutive androstane receptor (CAR) agonist that induces robust hepatocyte proliferation and hepatomegaly without any liver injury or tissue loss. TCPOBOP attenuates Fas-induced murine liver injury by altering Bcl-2 proteins. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 76150-91-9. Molecular formula: C16H8Cl4N2O2. Mole weight: 402.06. Purity: 0.9807. Product ID: ACM76150919. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TCPOBOP | TCPOBOP. Group: Biochemicals. Grades: Purified. CAS No. 76150-91-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TCPOBOP | TCPOBOP is an constitutive androstane receptor (mCAR) agonist with EC50 value of 20 nM. But it is effective for the mouse receptor but not for human or rat CAR receptors. TCPOBOP can induce cytochrome P450 monooxygenases and multidrug resistance and xenobiotic efflux proteins. Synonyms: 1,4-bis((3,5-dichloropyridin-2-yl)oxy)benzene;2,2'-(1,4-Phenylenebis(oxy))bis(3,5-dichloropyridine). Grades: 98%. CAS No. 76150-91-9. Molecular formula: C16H8Cl4N2O2. Mole weight: 402.06. |  |
| TCPOBOP | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. |  |
| TCPP | Ultra-high sensitive spectrophotometric reagent for Cu, Cd. Group: Uv/visible (uv/vis) spectroscopy. Alternative Names: Tetrakis(4-carboxyphenyl)porphyrin. | |
| TCPP-Cd(2+) | TCPP-Cd(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: cadmium(2+); hydron; 4-[10,15,20-tris(4-carboxylatophenyl)porphyrin-22,24-diid-5-yl]benzoate. CAS No. 82404-76-0. Molecular formula: 898.14. Mole weight: C48H24N4O8Cd-4·H+. 95%. |  |
| TCPP-Cu(2+) | TCPP-Cu(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: Cu(II) meso-Tetra(4-carboxyphenyl)porphine. CAS No. 41699-93-8. Molecular formula: 852.30. Mole weight: C48H28CuN4O8. 95%. | |
| TCPP-Mg(2+) | TCPP-Mg(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: (SP-4-1)-Magnesate(4-), [[4, 4', 4'', 4'''-(21H, 23H-porphine-5, 10, 15, 20-tetrayl-|EN21, |EN22, |EN23, |EN24)tetrakis[benzoato]](6-)]-, tetrahydrogen. CAS No. 212312-42-0. Molecular formula: 810.04. Mole weight: C48H24N4O8Mg-4·H+. 95%. | |
| TCPP, mixture of isomers | analytical standard. Group: Pesticides & metabolites standards. | |
| TCPP-Mn(2+) | TCPP-Mn(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: Endo-Mn-meso-tetra(4-carboxyphenyl)porphine; hydron,manganese(2+),4-[10,15,20-tris(4-carboxylatophenyl)porphyrin-22,24-diid-5-yl]benzoate. CAS No. 73202-95-6. Molecular formula: 840.67. Mole weight: C48H24N4O8Mn-4·H+. 95%. | |
| TCPP-Ni(2+) | TCPP-Ni(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: meso-Tetra(4-carboxyphenyl)porphine-Ni(II); 5,10,15,20-Tetrakis(4-Carboxyphenyl)porphyrin-Ni(II). CAS No. 41699-92-7. Molecular formula: 847.45. Mole weight: C48H28N4NiO8. 95%. | |
| TCPP-Pd(2+) | TCPP-Pd(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: Pd(II) meso-Tetra(4-carboxyphenyl)porphine. CAS No. 94288-44-5. Molecular formula: 895.20. Mole weight: C48H28N4O8Pd. 95%. | |
| TCPP [=Tetrakis(4-carboxyphenyl)porphyrin] [Ultra-high sensitive spectrophotometric reagent for Cu, Cd] [For the simultaneous determination of metals by HPLC] | TCPP [=Tetrakis(4-carboxyphenyl)porphyrin] [Ultra-high sensitive spectrophotometric reagent for Cu, Cd] [For the simultaneous determination of metals by HPLC]. Group: Ligands for functional metal complexesphthalocyanine dyes, porphyrin dyes. CAS No. 14609-54-2. Product ID: 4-[10,15,20-tris(4-carboxyphenyl)-21,23-dihydroporphyrin-5-yl]benzoic acid. Molecular formula: 790.8g/mol. Mole weight: C48H30N4O8. C1=CC (=CC=C1C2=C3C=CC (=C (C4=NC (=C (C5=CC=C (N5)C (=C6C=CC2=N6)C7=CC=C (C=C7)C (=O)O)C8=CC=C (C=C8)C (=O)O)C=C4)C9=CC=C (C=C9)C (=O)O)N3)C (=O)O. InChI=1S/C48H30N4O8/c53-45 (54)29-9-1-25 (2-10-29)41-33-17-19-35 (49-33)42 (26-3-11-30 (12-4-26)46 (55)56)37-21-23-39 (51-37)44 (28-7-15-32 (16-8-28)48 (59)60)40-24-22-38 (52-40)43 (36-20-18-34 (41)50-36)27-5-13-31 (14-6-27)47 (57)58/h1-24, 49, 52H, (H, 53, 54) (H, 55, 56) (H, 57, 58) (H, 59, 60). HHDUMDVQUCBCEY-UHFFFAOYSA-N. | |
| TCPP-Zn(2+) | TCPP-Zn(2+). Group: Porphyrin-metallo-porphyrines. Alternative Names: Zinc(II) tetrakis(4-carboxyphenyl)porphine; Zn(II) Meso-tetra(4-carboxyphenyl) porphine. CAS No. 27647-84-3. Molecular formula: 850.12. Mole weight: C48H24N4O8-6·Zn+2. 95%. | |
| TC-PTP Active human | recombinant, expressed in E. coli, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| TCPZ | TCPZ. Uses: Host material containing a triazine core and three phenylcarbazole arms for phosphorescent organic light-emitting diodes. Group: Organic light-emitting diode (oled) materials. Alternative Names: 2,4,6-Tris(3-(carbazol-9-yl)phenyl)triazine. CAS No. 890148-68-2. Product ID: 9-[3-[4,6-bis(3-carbazol-9-ylphenyl)-1,3,5-triazin-2-yl]phenyl]carbazole. Molecular formula: 804.94. Mole weight: C57H36N6. C1=CC=C2C (=C1) C3=CC=CC=C3N2C4=CC=CC (=C4) C5=NC (=NC (=N5) C6=CC (=CC=C6) N7C8=CC=CC=C8C9=CC=CC=C97) C1=CC (=CC=C1) N1C2=CC=CC=C2C2=CC=CC=C21. InChI=1S/C57H36N6/c1-7-28-49-43 (22-1)44-23-2-8-29-50 (44)61 (49)40-19-13-16-37 (34-40)55-58-56 (38-17-14-20-41 (35-38)62-51-30-9-3-24-45 (51)46-25-4-10-31-52 (46)62)60-57 (59-55)39-18-15-21-42 (36-39)63-53-32-11-5-26-47 (53)48-27-6-12-33-54 (48)63/h1-36H. KOUVXIWGXJSZHF-UHFFFAOYSA-N. | |
| T.cruzi Inhibitor | T.cruzi Inhibitor is a novel inhibitor of Trypanosoma cruzi. Synonyms: N-Benzyl-N-methyl-1-(4-(trifluoromethyl)benzyl)piperidine-3-carboxamide. CAS No. 1350920-22-7. Molecular formula: C22H25F3N2O. Mole weight: 390.45. | |
| TCS 1102 | TCS 1102 is a potent, dual orexin receptor antagonist with Ki values of 0.2 and 3 nM for OX2 and OX1 receptors respectively. It is a poor substrate for P-glycoprotein, which demonstrates good brain penetration when administered intraperitoneally. It were found to decrease fear and anxiety in rats 14 days after exposure to footshock. It was also found to have anxiolytic effects that were specific for HR when tested in the elevated T-maze. Uses: Tcs 1102 was found to have anxiolytic effects. Synonyms: N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl-2-pyrrolidinedicarboxamide;2-PyrrolidinecarboxaMide, N-[1,1'-biphenyl]-2-yl-1-[2-[(1-Methyl-1H-benziMidazol-2-yl)thio]acetyl]-, (2S)-;(2S)-N-[1,1'-Biphenyl]-2-yl-1-[2-[(1-methyl-1H-benzimidazol-2-yl)thio]acetyl]-2-pyrrolidinecarboxamide;TCS 1102, TCS1102, TCS-1102;(2S)-1-[2-(1-methylbenzimidazol-2-yl)sulfanylacetyl]-N-(2-phenylphenyl)pyrrolidine-2-carboxamide. Grades: >98 %. CAS No. 916141-36-1. Molecular formula: C27H26N4O2S. Mole weight: 470.59. | |
| TCS-1102 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TCS 1105 | TCS 1105. Group: Biochemicals. Grades: Purified. CAS No. 185391-33-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS 1105 | TCS 1105 is a GABAA benzodiazepine receptor (BZR) ligand that acts as an agonist at α2 and antagonist at α1 benzodiazepine receptors (Ki = 118 and 245 nM, respectively). Synonyms: TCS 1105; TCS1105; TCS-1105; N-[(-4-Fluorophenyl)methyl]-α-oxo-1H-indole-3-acetamide. Grades: ≥99% by HPLC. CAS No. 185391-33-7. Molecular formula: C17H13FN2O2. Mole weight: 296.3. | |
| TCS 1205 | TCS 1205 is a GABAA α2 benzodiazepine receptor agonist and GABAA α1 partial agonist in vitro (Ki = 14 and 121 nM, respectively). It displays non-sedative anxiolytic activity in vivo. Synonyms: TCS 1205; TCS1205; TCS-1205; 5-Nitro-α-oxo-N-(1R)-phenylethyl]-1H-indole-3-acetamide; 2-(5-nitro-1H-indol-3-yl)-2-oxo-N-[(1R)-1-phenylethyl]acetamide. Grades: ≥99% by HPLC. CAS No. 355022-97-8. Molecular formula: C18H15N3O4. Mole weight: 337.33. | |
| TCS 1205 | TCS 1205. Group: Biochemicals. Grades: Purified. CAS No. 355022-97-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS 183 | TCS 183. Group: Biochemicals. Grades: Purified. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TCS 183 | TCS 183 is a fragment 1-13 of human and mouse GSK-3β sequence. TCS 183 is potentially used as a competitive inhibitor of GSK-3β (Ser9) phosphorylation. Synonyms: TCS 183; TCS183; TCS-183. Molecular formula: C58H96N20O20S. Mole weight: 1425.58. | |
| TCS 184 | TCS 184 is a scrambled control peptide for use with TCS 183. Synonyms: TCS 184; TCS184; TCS-184. CAS No. 1315378-71-2. Molecular formula: C58H96N20O20S. Mole weight: 1425.58. | |
| TCS 184 | TCS 184. Group: Biochemicals. Grades: Purified. CAS No. 1315378-71-2. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TCS 2002 | TCS 2002. Group: Biochemicals. Grades: Purified. CAS No. 1005201-24-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS 2002 | TCS 2002 is a potent and cell-permeable inhibitor of GSK-3β (IC50 = 35 nM). Oral adminstration of TCS 2002 inhibits cold water stress-induced tau hyperphosphorylation in the mouse brain. Synonyms: TCS-2002; TCS 2002; TCS2002; 2-Methyl-5-[3-[4-(methylsulfinyl)phenyl]-5-benzofuranyl]-1,3,4-oxadiazole. Grades: ≥99% by HPLC. CAS No. 1005201-24-0. Molecular formula: C18H14N2O3S. Mole weight: 338.38. | |
| TCS 21311 | TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM) with selectivity for JAK3 over JAK1, JAK2 and TYK2 (IC50 = 1017, 2550 and 8055 nM, respectively). It also inhibits GSK-3β, PKCα and PKCθ (IC50 = 3, 13 and 68 nM, respectively). Synonyms: NIBR3049; NIBR-3049; NIBR 3049; TCS-21311; TCS 21311; TCS21311; 3-[5-[4-(2-Hydroxy-2-methyl-1-oxopropyl)-1-piperazinyl]-2-(trifluoromethyl)phenyl]-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione. Grades: ≥98% by HPLC. CAS No. 1260181-14-3. Molecular formula: C27H25F3N4O4. Mole weight: 526.51. | |
| TCS 21311 | TCS 21311. Group: Biochemicals. Grades: Purified. CAS No. 1260181-14-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS-21311 | A potent JAK3 inhibitor; selective for JAK3 over JAK1, JAK2 and TYK2. It also inhibits GSK-3 β, PKCα and PKC?. Group: Biochemicals. Alternative Names: 3-[5-[4- (2-Hydroxy-2-methyl-1-oxopropyl) -1-piperazinyl]-2- (trifluoromethyl) phenyl]-4- (1H-indol-3-yl) -1H-pyrrole-2, 5-dione; TCS 21311. Grades: Highly Purified. CAS No. 1260181-14-3. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TCS 2210 | TCS 2210. Group: Biochemicals. Grades: Purified. CAS No. 1201916-31-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS-2210 | TCS 2210 is a small molecule inducer of neuronal differentiation. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TCS-2210; TCS 2210; TCS2210. Product Category: Others. Appearance: To be determined. CAS No. 1201916-31-5. Molecular formula: C18H17N3O3. Mole weight: 323.35. Purity: >98%. IUPACName: 1,2-dihydro-N-hydroxy-2-oxo-3-(3-phenylpropyl)-6-quinoxalinecarboxamide. Canonical SMILES: O=C(C1=CC2=C(NC(C(CCCC3=CC=CC=C3)=N2)=O)C=C1)NO. Product ID: ACM1201916315. Alfa Chemistry ISO 9001:2015 Certified. | |
| TCS 2312 | TCS 2312. Group: Biochemicals. Grades: Purified. CAS No. 838823-31-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TCS 2312 | TCS 2312 is a potent checkpoint kinase 1 (chk1) inhibitor (Ki = 0.38 nM, EC50 = 60 nM). TCS 2312 potentiates the cell killing activity of Gemcitabine in breast and prostate cancer cell lines, and exhibits antiproliferative effects in vitro. Synonyms: TCS 2312; TCS2312; TCS-2312; 4'-[5-[[3-[ (Cyclopropylamino) methyl]phenyl]amino]-1H-pyrazol-3-yl]-[1, 1'-biphenyl]-2, 4-diol. Grades: ≥97% by HPLC. CAS No. 838823-31-7. Molecular formula: C25H24N4O2. Mole weight: 412.48. | |
| TCS 2314 | TCS 2314 is an integrin very late antigen-4 (VLA-4; α4β1) antagonist (IC50 = 4.4 nM) that inhibits the activation of inflammatory cells. Synonyms: TCS2314, TCS 2314, TCS-2314; 1-[[ (3S) -4-[2-[4-[[[ (2-Methylphenyl) amino]carbonyl]amino]phenyl]acety]l-3-morpholinyl]carbonyl]-4-piperidinediacetic acid. Grades: ≥99% by HPLC. CAS No. 317353-73-4. Molecular formula: C28H34N4O6. Mole weight: 522.59. | |
| TCS 2314 | TCS 2314. Group: Biochemicals. Grades: Purified. CAS No. 317353-73-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS 2510 | TCS 2510. Group: Biochemicals. Grades: Purified. CAS No. 346673-06-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TCS 2510 | TCS 2510 is a selective EP4 agonist (EC50 = 2.5 nM; Ki = 1.2 nM) that displays no significant binding at other prostaglandin receptors at concentrations up to 14 μM. EP4 agonist improves bone healing, provides cardio- and neuroprotection, and reduces inflammation and renal dysfunction. Synonyms: TCS 2510, TCS-2510, TCS2510; (5R)-5-[(3S)-3-Hydroxy-4-phenyl-1-buten-1-yl]-1-[6-(2H-tetrazol-5-yl)hexyl]-2-pyrrolidinone; 5-(3-hydroxy-4-phenylbut-1-enyl)-1-[6-(2H-tetrazol-5-yl)hexyl]pyrrolidin-2-one. Grades: ≥98% by HPLC. CAS No. 346673-06-1. Molecular formula: C21H29N5O2. Mole weight: 383.49. | |
| TCS 3035 | TCS 3035 is a GPR35 agonist (pEC50 = 5.13 and 5.86 for rat and human GPR35 orthologs, respectively). Synonyms: TCS-3035; TCS 3035; TCS3035; 2-[4-[ (Z) - (2, 4-Dioxo-5-thiazolidinylidene) methyl]phenoxyacetic acid; GPR35 Agonist, Compound 10. Grades: ≥98% by HPLC. CAS No. 871085-49-3. Molecular formula: C12H9NO5S. Mole weight: 279.27. | |
| TCS 3035 | TCS 3035. Group: Biochemicals. Grades: Purified. CAS No. 871085-49-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS 359 | TCS 359. Group: Biochemicals. Alternative Names: 2- [ (3, 4-Dimethoxybenzoyl) amino]-4, 5, 6, 7-tetrahydrobenzo [b]thiophene-3-carboxamide. Grades: Highly Purified. CAS No. 301305-73-7. Pack Sizes: 10mg. Molecular Formula: C18H20N2O4S, Molecular Weight: 360.43. US Biological Life Sciences. | Worldwide |
| TCS-359 | TCS-359 is a potent inhibitor of FLT3 with IC50 of 42 nM. Synonyms: TCS359, TCS 359, TCS-359. Grades: 0.98. CAS No. 301305-73-7. Molecular formula: C18H20N2O4S. Mole weight: 360.428. | |
| TCS 401 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TCS 401 | TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki = 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2, respectively). Several PTPs have been proposed to act as negative regulators of insulin signaling, suggesting PTP as a potential drug target in diabetes. Synonyms: Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, hydrochloride (1:1); Thieno[2,3-c]pyridine-3-carboxylic acid, 2-[(carboxycarbonyl)amino]-4,5,6,7-tetrahydro-, monohydrochloride; 2-(Carboxyformamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride; TCS401; TCS-401; 2-[(Carboxycarbonyl)amino]-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 243966-09-8. Molecular formula: C10H10N2O5S.HCl. Mole weight: 306.72. | |
| TCS 401 | TCS 401. Group: Biochemicals. Grades: Purified. CAS No. 243966-09-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TCS 46b | TCS 46b. Group: Biochemicals. Grades: Purified. CAS No. 302799-86-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS 46b | TCS 46b is a subtype-selective NR1A/NR2B NMDA receptor antagonist (IC50 = 5.3, 35000 and > 100000 nM for NR1A/2B, NR1A/2A and NR1A/2C receptor subtypes, respectively). TCS 46b potentiates the effect of L-DOPA in 6-OHDA-lesioned rats following oral administration. Synonyms: 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-; 1,3-Dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propyn-1-yl]-2H-benzimidazol-2-one; 2H-Benzimidazol-2-one, 1,3-dihydro-5-[3-[4-(phenylmethyl)-1-piperidinyl]-1-propynyl]-; 5-(3-(4-benzylpiperidin-1-yl)prop-1-yn-1-yl)-1,3-dihydro-2H-benzo[d]imidazol-2-one; TCS 46B. Grades: ≥98% by HPLC. CAS No. 302799-86-6. Molecular formula: C22H23N3O. Mole weight: 345.44. | |
| TCS 5861528 | TCS 5861528 is a selective TRPA1 blocker with IC50 values are 14.3 and 18.7μM respectively), attenuates diabetes mellitus hypersensitivity and displays antinociceptive properties. Uses: A potent and selective trpa1 (trp ankyrin 1) channel antagonist. Synonyms: Chembridge-5861528;TCS5861528, TCS-5861528, TCS 5861528, N-(4-butan-2-ylphenyl)-2-(1,3-dimethyl-2,6-dioxopurin-7-yl)acetamide. Grades: >98 %. CAS No. 332117-28-9. Molecular formula: C19H23N5O3. Mole weight: 369.42. | |
| TCS 5861528 | TCS 5861528. Group: Biochemicals. Grades: Purified. CAS No. 332117-28-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-S 7001 | TC-S 7001 is a potent and highly selective ROCK inhibitor. Its IC50 values are 0.6 and 1.1 nM for ROCK1 and ROCK2, respectively. It exhibits >200-fold selectivity over TRK and FLT3 receptors, and >900-fold selectivity over a panel of other kinases and cardiovascular relevent enzymes and receptors. It reduces blood pressure in normotensive and hypertensive rats. Synonyms: TC-S 7001; TC S 7001; TCS 7001; TC-S-7001; TCS7001; Azaindole-1; Azaindole 1; 6-Chloro-N4-{3,5-difluoro-4-[(3-methyl-1H-pyrrolo[2,3-b]pyridin-4-yl)oxy]phenyl}pyrimidine-2,4-diamine;Rho Kinase Inhibitor;ROCK inhibitor;ROCK. Grades: >98 %. CAS No. 867017-68-3. Molecular formula: C18H13ClF2N6O. Mole weight: 402.79. | |
| TC-S 7003 | TC-S 7003. Group: Biochemicals. Grades: Purified. CAS No. 847950-09-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-S 7005 | TC-S 7005. Group: Biochemicals. Grades: Purified. CAS No. 1082739-92-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-S 7005 | TC-S 7005 is a potent and selective polo-like kinase 2 (PLK2) inhibitor (IC50 = 4 nM) with selectivity over PLK3 and PLK1 (IC50 = 24 and 214 nM, respectively). TC-S 7005 has been shown to induce mitotic arrest and cell death in HCT 116 colorectal cells. Synonyms: TC-S 7005; TC S 7005; TCS 7005; TCS-7005; TCS7005; 3-(1,3-Benzodioxol-5-yl)-N-[(1S)-1-phenylethyl]-isoxazolo[5,4-c]pyridin-5-amine; 2-amino-isoxazolopyridine. Grades: ≥98% by HPLC. CAS No. 1082739-92-1. Molecular formula: C21H17N3O3. Mole weight: 359.38. | |
| TC-S 7006 | TC-S 7006 is a potent, selective and reversible Tpl2 (Cot; MAP3K8) inhibitor (IC50 = 50 nM) with selectivity for Tpl2 over MEK, p38, Src, MK2, PKC and EGFR. TC-S 7006 was shown to inhibit LPS-induced TNF-α secretion from primary human monocytes and attenuate acute myeloid leukemia (AML) cell proliferation in vitro. TC-S 7006 also suppresses cytolytic activity of human CD8+ cytotoxic T lymphocytes. Synonyms: 4-[(3-Chloro-4-fluorophenyl)amino]-6-[(3-pyridinylmethyl)amino]-1,7-naphthyridine-3-carbonitrile; TC-S 7006; TC S 7006; TCS 7006; Tpl2 Kinase Inhibitor. Grades: ≥99% by HPLC. CAS No. 871307-18-5. Molecular formula: C21H14ClFN6. Mole weight: 404.83. | |
| TC-S 7006 | TC-S 7006. Group: Biochemicals. Grades: Purified. CAS No. 871307-18-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-S 7009 | TC-S 7009. Group: Biochemicals. Grades: Purified. CAS No. 1422955-31-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-S 7009 | TC-S 7009 is a high affinity and selective HIF-2α inhibitor (Kd = 81 nM) that displays >60-fold selectivity for HIF-2α over HIF-1&alpha. TC-S 7009 binds to the HIF-2α PAS-B domain to disrupt HIF-2α-ARNT heterodimerization, decrease HIF-2α DNA-binding and suppress expression of HIF-2α target genes in vitro. Synonyms: TCS 7009; TC S 7009; TC-S 7009; N-(3-Chloro-5-fluorophenyl)-4-nitro-2,1,3-benzoxadiazol-5-amine. Grades: ≥99% by HPLC. CAS No. 1422955-31-4. Molecular formula: C12H6ClFN4O3. Mole weight: 308.65. | |
| TC-S 7010 | TC-S 7010. Group: Biochemicals. Grades: Purified. CAS No. 1158838-45-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS ERK 11e | Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM). Orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 896720-20-0. Pack Sizes: 10mg. Molecular Formula: C24H20Cl2FN5O2. US Biological Life Sciences. | Worldwide |
| TCS ERK 11e (Potent and Selective ERK2 Inhibitor, 4-[2-[(2-Chloro-4-fluorophenyl)amino]-5-methyl-4-pyrimidinyl]-N-[(1S)-1-(3-chlorophenyl)-2-hydroxyethyl]-1H-pyrrole-2-carboxamide) | Potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852nm for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48nm). Orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 896720-20-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TCS HDAC6 20b | TCS HDAC6 20b. Group: Biochemicals. Grades: Purified. CAS No. 956154-63-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TCS HDAC6 20b | TCS HDAC6 20b is a histone deacetylase 6 (HDAC6) inhibitor. TCS HDAC6 20b inhibits HCT116 growth at a concentration of 5 μM in combination with taxol. It also inhibits growth of MCF-7 cells stimulated by estrogen. Synonyms: NCT-14b; NCT 14b; NCT14b; 2-Methylpropanethioic acid-S-[(6S)-6-[[(1,1-dimethylethoxy)carbonyl]amino]-7-oxo-7-(tricyclo[3.3.1.13,7]dec-1-ylamino)heptyl] ester. Grades: ≥98% by HPLC. CAS No. 956154-63-5. Molecular formula: C26H44N2O4S. Mole weight: 480.7. | |
| TCS JNK 5a | TCS JNK 5a. Group: Biochemicals. Grades: Purified. CAS No. 312917-14-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS JNK 6o | TCS JNK 6o. Group: Biochemicals. Grades: Purified. CAS No. 894804-07-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCS JNK 6o | TCS JNK 6o is an ATP-competitive c-Jun N-terminal kinase (JNK) inhibitor with Kis of 2, 4 and 52 nM for JNK1, JNK2 and JNK3, respectively, and IC50s of 45 and 160 nM for JNK1 and JNK2, respectively. It shows >1000-fold selectivity over other kinases, including ERK2 and p38. It can inhibit apoptosis, caspase cleavage and cytochrome C release. Synonyms: JNK Inhibitor VIII; N-(4-Amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxybenzeneacetamide; Benzeneacetamide, N-(4-amino-5-cyano-6-ethoxy-2-pyridinyl)-2,5-dimethoxy-. Grades: ≥98% by HPLC. CAS No. 894804-07-0. Molecular formula: C18H20N4O4. Mole weight: 356.38. | |
| TC SL C5 | TC SL C5 is a metastasis-associated lung adenocarcinoma transcript 1 (Malat1) RNA inhibitor. Synonyms: 5-(4-Methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-Imidazol-2-amine. Grades: ≥98% by HPLC. CAS No. 827327-28-6. Molecular formula: C19H21N3O2. Mole weight: 323.4. | |
| TCS OX2 29 | TCS OX2 29 is a potent and selective OX2 receptor antagonist (IC50 = 40 nM) displaying >250-fold selectivity for OX2 over OX1 and a range of receptors, ion channels and transporters. Orexin is a neuropeptide produced in the lateral hypothalamus (LH) regulates arousal, pain and appetite. Synonyms: (2S)-1-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-3,3-dimethyl-2-[(4-pyridinylmethyl)amino]-1-butanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 372523-75-6. Molecular formula: C23H31N3O3.HCl. Mole weight: 433.97. | |
| TCS OX2 29 | TCS OX2 29. Group: Biochemicals. Grades: Purified. CAS No. 372523-75-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
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