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| Product | Description | |
|---|---|---|
| TC-E 5003 | TC-E 5003 is a selective protein arginine methyltransferase 1 ( PRMT1 ) inhibitor with an IC 50 of 1.5 μM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 17328-16-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-107574. |  |
| TC-E 5003 | TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM) with no inhibitory effects on CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Synonyms: TC-E 5003; TC E 5003; TCE 5003; TCE-5003; TCE5003; N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide); 4-(2,2-Dichloroacetamido)phenyl sulfone. Grades: ≥98% by HPLC. CAS No. 17328-16-4. Molecular formula: C16H14Cl2N2O4S. Mole weight: 401.26. |  |
| TC-E 5003 | TC-E 5003. Group: Biochemicals. Grades: Purified. CAS No. 17328-16-4. Pack Sizes: 50mg. US Biological Life Sciences. |  Worldwide |
| TC-E 5005 | TC-E 5005 is a potent and selective PDE10A inhibitor (IC50 = 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively, and >5000 nM at PDE1B, 4A, 6, 8A and 9A). TC-E 5005 reverses MK 801-induced hyperactivity and stereotypy in vivo. It also inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate. Synonyms: TC-E 5005; TC E-5005; TC E 5005; TC-E-5005; TCE5005; 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine. Grades: ≥99% by HPLC. CAS No. 959705-64-7. Molecular formula: C15H18N4O. Mole weight: 270.33. | |
| TC-E 5005 | TC-E 5005. Group: Biochemicals. Grades: Purified. CAS No. 959705-64-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5006 | TC-E 5006, also called BIIB042, is a potent γ-secretase modulator, which lowered Aβ42, increased Aβ38, but had little to no effect on Aβ40 levels both in vitro and in vivo. In addition, it did not affect Notch signaling in our in vitro assessment. Aβ42: EC50 = 0.17 μM. Synonyms: TC-E 5006; TCE 5006; TC E 5006; TC-E-5006; TCE5006; 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid; BIIB042. CAS No. 1257395-14-4. Molecular formula: C29H29F4NO2. Mole weight: 499.54. | |
| TC-E 5006 | TC-E 5006. Group: Biochemicals. Grades: Purified. CAS No. 1257395-14-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5007 | TC-E 5007. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5007 | TC-E 5007 is an irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 = 145 and 242 nM, respectively) with selectivity over DPP-IV, DPP-2 and FAP. Synonyms: TC-E 5007; TC E 5007; TCE 5007; TCE-5007; TCE5007; (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 1883545-48-9. Molecular formula: C14H20N2O.HCl. Mole weight: 268.78. | |
| TC-E 5008 | TC-E 5008 is a selective and cancer-associated mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM), displaying >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. TC-E 5008 also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Synonyms: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 6-benzyl-1-hydroxy-4-methylpyridin-2-one. CAS No. 50405-58-8. Molecular formula: C13H13NO2. Mole weight: 215.25. | |
| TCEP-d12 Hydrochloride | Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay. Group: Biochemicals. Alternative Names: 3, 3', 3''-Phosphinidynetri spropanoic Acid-d12; Tris(2-carboxyethyl)phosphine-d12 Hydrochloride; Tris (carboxyethyl) phosphine-d12 Hydrochloride. Grades: Highly Purified. CAS No. 1189959-10-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TCEP hydrochloride | TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tris(2-carboxyethyl)?phosphine hydrochloride. CAS No. 51805-45-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-W011500. | |
| TCEP Hydrochloride | TCEP Hydrochloride is used for selective reduction of disulfide bridges at low pH. Synonyms: TCEP.HCL; Tris(2-Carboxyethyl)Phosphine Hydrochloride; 3,3',3''-Phosphinetriyltripropanoic acid hydrochloride; TCEP HCl; TCEP; UNII-H49AAM893K; MFCD00145469; TCEP (hydrochloride); Tris(carboxyethyl)phosphine hydrochloride; H49AAM893K; Propanoic acid, 3,3',3''-phosphinidynetris-, hydrochloride. Grades: 98% (AT). CAS No. 51805-45-9. Molecular formula: C9H16ClO6P. Mole weight: 286.65. | |
| TCEP Hydrochloride | Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay. Group: Biochemicals. Alternative Names: 3, 3', 3''-Phosphinidynetri spropanoic Acid Hydrochloride; Tris(2-carboxyethyl)phosphine Hydrochloride; Tris (carboxyethyl) phosphine Hydrochloride; TCEP·HCl. Grades: Highly Purified. CAS No. 51805-45-9. Pack Sizes: 1g, 5g, 25g. Molecular Formula: C9H15O6P. US Biological Life Sciences. | Worldwide |
| TCF-1 | TCF-1. Uses: Designed for use in research and industrial production. Purity: 0.95. Product ID: ACMA00064460. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TC-F 2 | TC-F 2 is a potent, reversible and noncovalent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 28 and 100 nM for human and rat FAAH, respectively). Synonyms: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥99% by HPLC. CAS No. 1304778-15-1. Molecular formula: C26H25N5O2. Mole weight: 439.51. | |
| TC-F 2 | TC-F 2. Group: Biochemicals. Grades: Purified. CAS No. 1304778-15-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCFH | A safe, affordable reagent for ester and difficult amide synthesis. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: Chloro-N,N,N,N-tetramethylformamidinium hexafluorophosphate. CAS No. 207915-99-9. |  Luxembourg Bio Technologies |
| TC-FPR 43 | TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM) that inhibits fMLP- and IL-8-induced neutrophil migration and induces calcium mobilization. TC-FPR 43 was shown to suppress inflammation in a mouse model of acute inflammation. It also acts as an ALX agonist. Synonyms: TCFPR43; TC FPR 43; TC-FPR-43; N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea; Pyrazolone, 1. Grades: ≥98% by HPLC. CAS No. 903895-98-7. Molecular formula: C20H21ClN4O2. Mole weight: 384.86. | |
| TC-FPR 43 | TC-FPR 43. Group: Biochemicals. Grades: Purified. CAS No. 903895-98-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1000 | TC-G 1000 is a potent and orally bioactive α2D-adrenoceptor agonist (Ki = 8.6 pM and 110 nM for rat α2D and α1 receptors respectively, and 25, 26 and 100 nM for human α2A, α2C and α2B receptors respectively). TC-G 1000 displays analgesic activity in a mouse model of abdominal irritation. Synonyms: TC-G 1000; TC G 1000; TCG 1000; TCG1000; 4-(6,7-Dihydro-1,3-dimethylbenzo[c]thien-4-yl)-1H-imidazole maleate. Grades: ≥98% by HPLC. CAS No. 245744-18-7. Molecular formula: C13H14N2S.C4H4O4. Mole weight: 346.4. | |
| TC-G 1000 | TC-G 1000. Group: Biochemicals. Grades: Purified. CAS No. 245744-18-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1001 | TC-G 1001. Group: Biochemicals. Grades: Purified. CAS No. 494191-73-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1001 | TC-G 1001 is a GPR35 agonist (pEC50 = 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays, respectively) displaying 1000-fold greater potency at human GPR35 receptors than mouse and rat GPR35 orthologs in an IP1 accumulation assay. Synonyms: TC-G 1001; TC G 1001; TCG 1001; TC-G-1001; TCG1001; 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 494191-73-0. Molecular formula: C17H11FN2O3S. Mole weight: 342.34. | |
| TC-G 1003 | TC-G 1003 is a potent and high affinity somatostatin sst2 receptor agonist (Ki = 0.025 nM). TC-G 1003 exhibits an inhibitory effect on growth hormone secretion and attenuates laser-induced ocular neovascular lesion size in rats. Synonyms: TC-G1003; TC G1003; TCG1003; 3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphenyl)-6-quinolinyl]phenol. Grades: ≥98% by HPLC. CAS No. 1021912-42-4. Molecular formula: C26H25ClN2O2. Mole weight: 432.94. | |
| TC-G 1003 | TC-G 1003. Group: Biochemicals. Grades: Purified. CAS No. 1021912-42-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-G 1004 | TC-G 1004. Group: Biochemicals. Grades: Purified. CAS No. 1061747-72-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1004 | TC-G 1004 is a potent and selective A2A antagonist. Synonyms: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide. CAS No. 1061747-72-5. Molecular formula: C22H27N7O2. Mole weight: 421.5. | |
| TC-G 1005 | TC-G 1005 is a potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5) that selectively activates TGR5 over FXR (farnesoid X receptor). TC-G 1005 has been shown to increase plasma GLP-1 level and lower blood glucose level in mice. Synonyms: TC-G 1005; TC G 1005; TCG 1005; TC-G-1005; TCG1005; (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone. Grades: ≥98% by HPLC. CAS No. 1415407-60-1. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| TC-G 1006 | TC-G 1006. Group: Biochemicals. Grades: Purified. CAS No. 1324003-64-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1008 | TC-G 1008. Group: Biochemicals. Grades: Purified. CAS No. 1621175-65-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G-1008 | TC-G-1008, also known as GPR39-C3, is a potent and orally available GPR39 agonist (EC50= 0.4 and 0.8 nM for rat and human receptors respectively) with great selectivity for GPR39 over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Synonyms: GPR39-C3, GPR39C3, GPR39 C3, TC-G-1008, TC-G1008, TC-G 1008, TCG-1008, TCG1008, TCG 1008; N- [3-chloro-4- [ [ [2- (methylamino) -6-pyridin-2-ylpyrimidin-4-yl] amino] methyl] phenyl] methanesulfonamide; GPR39-C3; N- (3-chloro-4- ( ( (2- (methylamino) -6- (2-pyridinyl) -4-pyrimidinyl) amino) methyl) phenyl) methanesulfonamide; TC-G 1008. CAS No. 1621175-65-2. Molecular formula: C18H19ClN6O2S. Mole weight: 418.9. | |
| TC-G 24 | TC-G 24 is a potent and brain penetrating GSK-3β inhibitor (IC50 = 17 nM) with selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). TC-G 24 has been shown to increase liver glycogen reserves in rodents. Synonyms: TC-G 24; TC G 24; TCG 24; TCG-24; TCG24; N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine. Grades: ≥98% by HPLC. CAS No. 1257256-44-2. Molecular formula: C15H11ClN4O3. Mole weight: 330.73. | |
| TC-G 24 | TC-G 24. Group: Biochemicals. Grades: Purified. CAS No. 1257256-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-H 106 | TC-H 106. Group: Biochemicals. Grades: Purified. CAS No. 937039-45-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-H 106 | TC-H 106 is a slow, tight-binding inhibitor of class I HDAC, including HDAC 1, 2, and 3 with IC50 values of 150 nM , 760nM, and 370 nM, respectively. It demonstrats no activity against class II HDACs. It inhibits these enzymes through different mechanisms. It also has preference toward HDAC3 with K(I) of approximately 14 nm, 15 times lower than the K(I) for HDAC1. It exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM. It progressively binds HDACs and remains bound after wash-out. It may have therapeutic value in Friedrich's ataxia and Huntington's disease due to their low animal toxicity. Uses: Tc-h 106 may have therapeutic value in friedrich's ataxia and huntington's disease. Synonyms: TC-H 106, TC-H106, TC-H-106, TCH-106, TCH 106, TCH106, Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106;N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide;N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide;RGFA-8;Histone Deacetylase Inhibitor VII. Grades: >99 %. CAS No. 937039-45-7. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| TC HSD 21 | TC HSD 21. Group: Biochemicals. Grades: Purified. CAS No. 330203-01-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC HSD 21 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 = 6 and 40 nM at human and mouse 17β-HSD3, respectively) with no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors. Synonyms: TC HSD 21; TC-HSD-21; TCHSD21; TC-HSD 21; 5-[(3-Bromo-4-hydroxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone. Grades: ≥99% by HPLC. CAS No. 330203-01-5. Molecular formula: C17H12BrNO3S2. Mole weight: 422.32. | |
| TC HSD 21 (5-[ (3-Bromo-4-hydroxyphenyl) methylene]-3- (4-methoxyphenyl) -2-thioxo-4-thiazolidinone) | Potent 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitor (IC50 values are 6 and 40nm at human and mouse 17beta-HSD3 respectively). Displays no activity at 17beta-HSD1, 17beta-HSD2, ERalpha, androgen receptors or glucocorticoid receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 330203-01-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-I 15 | TC-I 15 is a potent α2β1 integrin inhibitor (IC50 = 12 and 715 nM for the inhibition of human platelet adhesion to type I collagen and for platelets under static conditions and under flow, respectively), displaying selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 was shown to reduce collagen IV production in mesangial cells. Synonyms: TC-I 15; TCI 15; TC I 15; TCI15; N-[[ (4R)-5, 5-Dimethyl-3- (phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[ (phenylmethyl)amino]carbonyl]amino]-L-alanine. Grades: ≥98% by HPLC. CAS No. 916734-43-5. Molecular formula: C23H28N4O6S2. Mole weight: 520.62. | |
| TC-I 2000 | TC-I 2000 is a potent and orally bioactive TRPM8 channel blocker. TC-I 2000 was shown to inhibit icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM). Synonyms: TC-I2000; TC I 2000; TCI 2000; TCI2000; N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide; 2(1H)-Isoquinolinecarboxamide, N-(4-fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethyl-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-fluoro-phenyl)-amide. Grades: ≥99% by HPLC. CAS No. 1159996-20-9. Molecular formula: C23H18F4N2O. Mole weight: 414.40. | |
| TC-I 2000 | TC-I 2000. Group: Biochemicals. Grades: Purified. CAS No. 1159996-20-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-I 2014 | TC-I 2014 is a potent TRPM8 antagonist (IC50 = 0.8, 3.0 and 4.4 nM for canine, human and rat channels, respectively) displaying antiallodynic properties in vivo. Synonyms: TC-I 2014; TC I 2014; TCI 2014; 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene. Grades: ≥98% by HPLC. CAS No. 1221349-53-6. Molecular formula: C23H19F6N3O. Mole weight: 467.41. | |
| TC-I 2014 | TC-I 2014. Group: Biochemicals. Grades: Purified. CAS No. 1221349-53-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCID | TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC 50 of 0.6 μM [1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,5,6,7-Tetrachloroindan-1,3-dione. CAS No. 30675-13-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18638. | |
| TCID | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor. Grades: >98%. CAS No. 30675-13-9. Molecular formula: C9H2Cl4O2. Mole weight: 283.92. | |
| TCID | TCID. Group: Biochemicals. Grades: Purified. CAS No. 30675-13-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC JL 37 | TC JL 37 is a potent and orally available inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). TC JL 37 inhibits IFNγ production in vivo in mice. Synonyms: TCJL-37; TCJL 37; TCJL37; TC JL-37; TC JL 37; TC JL37; 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1258294-34-6. Molecular formula: C17H11ClF2N4O2. Mole weight: 376.74. | |
| TC KHNS 11 | TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor with preference for PI 3-Kδ over a panel of lipid and protein kinases. Synonyms: 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 1431540-99-6. Molecular formula: C28H24N6O3. Mole weight: 492.53. | |
| TC LPA5 4 | TC LPA5 4 is a LPA 5 (GPR92) -specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA 5 -RH7777 cell line) with an IC 50 of 800 nM. TC LPA5 4 displays selectivity for LPA 5 over 80 other screened agent targets [1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1393814-38-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107615. | |
| TC LPA5 4 | TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells), displaying selectivity for LPA5 against 80 other screened targets. TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets. Synonyms: LPA5-IN-4; LPA5-IN4; LPA5IN4, TC-LPA5-4; 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1393814-38-4. Molecular formula: C23H23ClN2O3. Mole weight: 410.89. | |
| TC LPA5 4 | TC LPA5 4. Group: Biochemicals. Grades: Purified. CAS No. 1393814-38-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCMCB07 | TCMCB07, a cyclic nonapeptide peptide, is an orally active and brain-penetrant melanocortin receptor 4 (MC4R) antagonist. TCMCB07 plays an important role in cachexia [1]. Uses: Scientific research. Group: Peptides. Alternative Names: Mifomelatide. CAS No. 1456699-27-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-P5971. | |
| TC-MCH 7c | TC-MCH 7c. Group: Biochemicals. Grades: Purified. CAS No. 864756-35-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-MCH 7c | TC-MCH 7c is a potent, selective and brain-penetrating antagonist of melanin-concentrating hormone receptor 1 (MCH1R) (IC50= 5.6 nM in hMCH1R-expressing CHO cells), displaying selectivity for MCH1R over MCH2R (IC50 = > 10 μM). Study shows that TC-MCH 7c reduces body weight in a mouse model of diet-induced obesity. Synonyms: TC-MCH 7c; TC MCH 7c; TCMCH 7c; 4-[(4-Fluorophenyl)methoxy]-1-[4-[2-(1-pyrrolidinyl)ethoxy]phenyl]-2(1H)-pyridinone. Grades: ≥97% by HPLC. CAS No. 864756-35-4. Molecular formula: C24H25FN2O3. Mole weight: 408.47. | |
| TCMDC-135051 | TCMDC-135051 is a highly selective and potent protein kinase Pf CLK3 inhibitor with low off-target toxicity. TCMDC-135051 prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 has antiparasiticidal activity (EC 50 =320 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2413716-15-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-126323. | |
| TCMDC-135051 hydrochloride | TCMDC-135051 hydrochloride is a highly selective and potent protein kinase Pf CLK3 inhibitor with low off-target toxicity. TCMDC-135051 hydrochloride prevents trophozoite-to-schizont transition, disrupts transcription and reduces transmission to the mosquito vector. TCMDC-135051 hydrochloride has antiparasiticidal activity (EC 50 =320 nM) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2705545-47-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-126323B. | |
| TC Mps1 12 | TC Mps1 12 is a potent and selective monopolar spindle 1 (Mps1) inhibitor (IC50 = 6.4 nM) with selectivity for Mps1 over a panel of 95 kinases including JNK. TC Mps1 12 has been shown to inhibit the proliferation of A549 lung carcinoma cell and the growth of A549 cell xenograft in mice. Synonyms: TC-Mps1-12; TC Mps1 12; TCMps112; TC-Mps1 12; 4-[[4-Amino-5-cyano-6-[(1,1-dimethylethyl)amino]-2-pyridinyl]amino]benzamide. Grades: ≥99% by HPLC. CAS No. 1206170-62-8. Molecular formula: C17H20N6O. Mole weight: 324.38. | |
| TC Mps1 12 | TC Mps1 12. Group: Biochemicals. Grades: Purified. CAS No. 1206170-62-8. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCMTB | TCMTB is one of the so-called emerging contaminants (EC). TCMTB is also an antifouling agent [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21564-17-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101425. | |
| TC-N 1752 | TC-N 1752. Group: Biochemicals. Grades: Purified. CAS No. 1211866-85-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-N 1752 | TC-N 1752 is a state-dependent human NaV channel inhibitor (IC50 = 0.17, 0.3, 0.4, 1.1 and 1.6 μM at hNaV1.7, hNaV1.3, hNaV1.4, hNaV1.5 and hNav1.9, respectively). TC-N 1752 inhibits Nav1.7 and exhibits analgesic efficacy in the formalin pain model. TC-N 1752 also inhibits tetrodotoxin-sensitive sodium channels. Synonyms: N-[2-Methyl-3-[[4-[4-[[4-(trifluoromethoxy)phenyl]methoxy]-1-piperidinyl]-1,3,5-triazin-2-yl]amino]phenyl]acetamide; Nav1.7 blocker 52. Grades: ≥99% by HPLC. CAS No. 1211866-85-1. Molecular formula: C25H27F3N6O3. Mole weight: 516.52. | |
| TCN 201 | TCN 201 is an NMDA receptor antagonist with selectivity for NR1/NR2A over NR1/NR2B-containing receptors (pIC50 = 6.8 and <4.3, respectively, in human recombinant NR1/NR2A and NR1/NR2B FLIPR/Ca2+ assays). Synonyms: TCN-201, TCN 201, TCN201; 3-Chloro-4-fluoro-N- [4- [ [2- (phenylcarbonyl) hydrazino] carbonyl] benzyl] benzenesulfonamide; QCR-22. Grades: ≥99% by HPLC. CAS No. 852918-02-6. Molecular formula: C21H17ClFN3O4S. Mole weight: 461.89. | |
| TCN 201 | TCN 201. Group: Biochemicals. Grades: Purified. CAS No. 852918-02-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCN-201 (3-Chloro-4-fluoro-N- [ (4-{ [2- (phenylcarbonyl) hydrazino] carbonyl}phenyl) methyl] benzenesulfonamide, NMDA Antagonist X) | A negative allosteric modulator selective for NR2A containingnMDA receptors (pIC50 = 6.8 and <4.3uM for NR2A and NR2B, respectively). No effect on NR2B-containingnMDA receptors with concentrations less than 50 mM. Inhibition on NR2A containingnMDA receptors is glycine (or D-serine)-binding, but not glutamate-binding, dependent. Group: Biochemicals. Grades: Highly Purified. CAS No. 852918-02-6. Pack Sizes: 5mg. US Biological Life Sciences. | Worldwide |
| TCN 213 | TCN 213. Group: Biochemicals. Alternative Names: N-(Cyclohexylmethyl)-2-[[5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl]thio]-acetamide. Grades: Highly Purified. CAS No. 556803-08-8. Pack Sizes: 10mg. Molecular Formula: C18H24N4OS2, Molecular Weight: 376.54. US Biological Life Sciences. | Worldwide |
| TCN 213 | TCN 213 is an NMDA receptor antagonist with selectivity for NR1/NR2A (pIC50 = 5.4) over NR1/NR2B. Synonyms: TCN 213; TCN213; TCN-213; N-(Cyclohexylmethyl)-2-[(5-[(phenylmethyl)amino]-1,3,4-thiadiazol-2-yl}thio]acetamide. Grades: ≥99% by HPLC. CAS No. 556803-08-8. Molecular formula: C18H24N4OS2. Mole weight: 376.54. | |
| TC-N 22A | TC-N 22A. Group: Biochemicals. Grades: Purified. CAS No. 1314140-00-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-N 22A | TC-N 22A is a potent and selective mGlu4 receptor positive allosteric modulator (EC50 = 9 nM in human mGlu4-expressing BHK cells) with selectivity over mGlu1, mGlu2, mGlu3, mGlu5 and mGlu7 receptors (EC50 > 10 μM). TC-N 22A is used for the treatment of Parkinson's disease, anxiety and pain. Uses: The treatment of parkinson's disease, anxiety and pain. Synonyms: 4, 5, 6, 8-Tetrahydro-N-2-pyridinylpyrazolo[3', 4':6, 7]cyclohepta[1, 2]thiazol-2-amine; N-pyridin-2-yl-4, 5, 6, 7-tetrahydropyrazolo[2, 3]cyclohepta[2, 4-b][1, 3]thiazol-2-amine. Grades: ≥98% by HPLC. CAS No. 1314140-00-5. Molecular formula: C14H13N5S. Mole weight: 283.35. | |
| TCN 237 dihydrochloride | TCN 237 dihydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 700878-19-9. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
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