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| Product | Description | |
|---|---|---|
| tC°-CE Phosphoramidite | tC°-CE Phosphoramidite, a chemical reagent essential in oligonucleotide synthesis for biomedical applications, boasts a thermally cleavable protecting group enabling streamlined purification and deprotection of the end product. Its widespread usage extends to the creation of RNA and DNA probes, utilized regularly in the diagnosis and treatment of maladies such as cancer and viral infections. Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-1'-(1,3-diaza-2-oxophenoxazin-1-yl)-2'-deoxy-ß-D-ribofuranosyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C45H50N5O8P. Mole weight: 819.88. |  |
| tC-CE Phosphoramidite | tC-CE Phosphoramidite, a bioorganic compound vital to the biomedicine industry, plays a significant role in synthesizing oligonucleotides used for studying and diagnosing various diseases, ranging from cancer to genetic disorders. Through its unique fluorescent properties, it offers an unparalleled capability to detect and analyze DNA and RNA sequences, unveiling new horizons in the field of bioanalytics. Synonyms: 5'-O-(4,4'-Dimethoxytrityl)-1'-(1,3-diaza-2-oxophenothiazin-1-yl)-2'-deoxy-ß-D-ribofuranosyl-3'-[(2-cyanoethyl)-(N,N-diisopropyl)]-phosphoramidite. Molecular formula: C45H50N5O7PS. Mole weight: 835.95. | |
| TC-DAPK 6 | TC-DAPK 6 is a potent, ATP-competitive, and highly selective DAPK inhibitor (IC50=69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 ?M ATP). Uses: Scientific research. Group: Signaling pathways. CAS No. 315694-89-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15513. |  |
| TC-DAPK 6 | An oxazalone compound that acts as a potent, ATP-competitive, and highly selective death-associated protein kinase (DAPK) inhibitor (IC50 = 69 and 225 nM against DAPK1 and DAPK3, respectively, with 10 μM ATP), while exhibiting much reduced or no activity against a panel of 48 other kinases even at concentrations as high as 10 μM. Synonyms: TC-DAPK 6; TC DAPK 6; TCDAPK6; DAPK Inhibitor; T6908224; T-6908224; T 6908224. Grades: >98%. CAS No. 315694-89-4. Molecular formula: C17H12N2O2. Mole weight: 276.29. | |
| TC-DAPK 6 | TC-DAPK 6. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TC E3 5031 | TC E3 5031 is a proteolysis targeting chimeras which allows for the optical control of protein degradation. Synonyms: 2-((2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindolin-4-yl)oxy)acetic acid; E3 ligase Ligand 3; Acetic acid, 2-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]-; Thalidomide-O-COOH; Thalidomide-Acid; SCHEMBL14085581; Thalidomide-O-COOH (Cereblon ligand 3); 2-[[2-(2,6-Dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]oxy]acetic acid. Grades: ≥ 98%. CAS No. 1061605-21-7. Molecular formula: C15H12N2O7. Mole weight: 332.26. | |
| TC-E3 5032 | TC-E3 5032 is a linker used in PROTAC technology that can be used in the synthesis of HDAC6 and anaplastic lymphoma kinase (ALK) degraders. Synonyms: E3 ligase Ligand 4; 1H-Isoindole-1,3(2H)-dione, 2-(2,6-dioxo-3-piperidinyl)-4-fluoro-; Thalidomide 4-fluoride; Thalidomide fluoride; 4-Fluoro-thalidomide; Cereblon ligand 4;E3 ligase Ligand 4; 2-(2,6-Dioxo-3-piperidinyl)-4-fluoro-1H-isoindole-1,3(2H)-dione. Grades: ≥ 98%. CAS No. 835616-60-9. Molecular formula: C13H9FN2O4. Mole weight: 276.22. | |
| TC-E 5001 | TC-E 5001. Group: Biochemicals. Grades: Purified. CAS No. 865565-29-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5001 | TC-E 5001 is a dual tankyrase (TNKS) inhibitor (Kd = 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that inhibits Wnt signaling and stabilizes Axin2 levels. Synonyms: TC-E 5001; TC E 5001; TCE5001; TCE-5001; TC-E-5001; 3-(4-Methoxyphenyl)-5-[[[4-(4-methoxyphenyl)-5-methyl-4H-1,2,4-triazol-3-yl]thio]methyl]-1,2,4-oxadiazole. Grades: ≥98% by HPLC. CAS No. 865565-29-3. Molecular formula: C20H19N5O3S. Mole weight: 409.46. | |
| TC-E 5002 | TC-E 5002 is a selective histone demethylase KDM2/7 subfamily inhibitor (IC50 = 0.2, 1.2, 6.8, 55, 83, >100 and >120 μM for KDM7A, KDM7B, KDM2A, KDM5A, KDM4C, KDM6A and KDM4A, respectively) with antitumor activity. It suppresses growth of HeLa and KYSE-150 cancer cells in vitro. Synonyms: TC-E 5002; TC E 5002; TCE 5002; TCE-5002; TCE5002; TC-E-5002; N-(9-Cyclopropyl-1-oxononyl)-N-hydroxy-β-alanine. Grades: ≥98% by HPLC. CAS No. 1453071-47-0. Molecular formula: C15H27NO4. Mole weight: 285.38. | |
| TC-E 5002 | TC-E 5002. Group: Biochemicals. Grades: Purified. CAS No. 1453071-47-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5003 | TC-E 5003 is a selective protein arginine methyltransferase 1 ( PRMT1 ) inhibitor with an IC 50 of 1.5 μM against hPRMT1. TC-E 5003 modulates the lipopolysaccharide (LPS) (HY-D1056)-induced AP-1 and NF-κB signaling pathways with anti-inflammatory properties. TC-E 5003 also upregulates the expression of Ucp1 and Fgf21, activates protein kinase A signaling and lipolysis in primary subcutaneous adipocytes from both mouse and humans. TC-E 5003 is promising for research of obesity and associated metabolic disorders, oxidative stress, inflammation and cancers [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. CAS No. 17328-16-4. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-107574. | |
| TC-E 5003 | TC-E 5003. Group: Biochemicals. Grades: Purified. CAS No. 17328-16-4. Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5003 | TC-E 5003 is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor (IC50 = 1.5 μM) with no inhibitory effects on CARM1 and Set7/9 methyltransferases. TC-E 5003 inhibits growth of MCF7a breast cancer cells and LNCaP prostate cancer cells. Synonyms: TC-E 5003; TC E 5003; TCE 5003; TCE-5003; TCE5003; N,N'-(Sulfonyldi-4,1-phenylene)bis(2-chloroacetamide); 4-(2,2-Dichloroacetamido)phenyl sulfone. Grades: ≥98% by HPLC. CAS No. 17328-16-4. Molecular formula: C16H14Cl2N2O4S. Mole weight: 401.26. | |
| TC-E 5005 | TC-E 5005 is a potent and selective PDE10A inhibitor (IC50 = 7.28, 239, 779, 919, 3100 and 3700 nM at PDE10A, 2A, 11A, 5A, 7B and 3A respectively, and >5000 nM at PDE1B, 4A, 6, 8A and 9A). TC-E 5005 reverses MK 801-induced hyperactivity and stereotypy in vivo. It also inhibits adrenergic and neurogenic smooth muscle contractions in the human prostate. Synonyms: TC-E 5005; TC E-5005; TC E 5005; TC-E-5005; TCE5005; 2-Methoxy-6,7-dimethyl-9-propyl-imidazo[1,5-a]pyrido[3,2-e]pyrazine. Grades: ≥99% by HPLC. CAS No. 959705-64-7. Molecular formula: C15H18N4O. Mole weight: 270.33. | |
| TC-E 5005 | TC-E 5005. Group: Biochemicals. Grades: Purified. CAS No. 959705-64-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5006 | TC-E 5006. Group: Biochemicals. Grades: Purified. CAS No. 1257395-14-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5006 | TC-E 5006, also called BIIB042, is a potent γ-secretase modulator, which lowered Aβ42, increased Aβ38, but had little to no effect on Aβ40 levels both in vitro and in vivo. In addition, it did not affect Notch signaling in our in vitro assessment. Aβ42: EC50 = 0.17 μM. Synonyms: TC-E 5006; TCE 5006; TC E 5006; TC-E-5006; TCE5006; 6-[(4-Fluorophenyl)(4-methyl-1-piperidinyl)methyl]-a-methyl-4'-(trifluoromethyl)-[1,1'-biphenyl]-3-acetic acid; BIIB042. CAS No. 1257395-14-4. Molecular formula: C29H29F4NO2. Mole weight: 499.54. | |
| TC-E 5007 | TC-E 5007 is an irreversible and selective dipeptidyl peptidase 8 and 9 (DPP-8/9) inhibitor (IC50 = 145 and 242 nM, respectively) with selectivity over DPP-IV, DPP-2 and FAP. Synonyms: TC-E 5007; TC E 5007; TCE 5007; TCE-5007; TCE5007; (2S,3R)-2-Amino-1-(1,3-dihydro-2H-isoindol-2-yl)-3-methyl-1-pentanone hydrochloride. Grades: ≥98% by HPLC. CAS No. 1883545-48-9. Molecular formula: C14H20N2O.HCl. Mole weight: 268.78. | |
| TC-E 5007 | TC-E 5007. Group: Biochemicals. Grades: Purified. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-E 5008 | TC-E 5008 is a selective and cancer-associated mutant isocitrate dehydrogenase 1 (mIDH1) inhibitor (Ki = 120-190 nM), displaying >60-fold selectivity for mIDH1 (found in ~75% of gliomas) over wild type IDH1. TC-E 5008 also inhibits D-2-hydroxyglutaric acid in cells expressing mIDH1 (EC50 = 2.4 μM). Synonyms: 1-Hydroxy-4-methyl-6-(phenylmethyl)-2-(1H)pyridinone; 6-benzyl-1-hydroxy-4-methylpyridin-2-one. CAS No. 50405-58-8. Molecular formula: C13H13NO2. Mole weight: 215.25. | |
| TCEP-d12 Hydrochloride | Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay. Group: Biochemicals. Alternative Names: 3, 3', 3''-Phosphinidynetri spropanoic Acid-d12; Tris(2-carboxyethyl)phosphine-d12 Hydrochloride; Tris (carboxyethyl) phosphine-d12 Hydrochloride. Grades: Highly Purified. CAS No. 1189959-10-1. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| TCEP hydrochloride | TCEP hydrochloride (Tris(2-carboxyethyl)phosphine hydrochloride) is a non-thiol reducing agent that is more stable and produces a faster S-S reductive reaction than other chemical reductants. TCEP hydrochloride is a trialkylphosphine, selectively reduces protein disuldes without altering the properties or interacting with thiol-directed agents in the reaction mixture. TCEP hydrochloride is also a commonly used reducing agent in the DNA/AuNP chemistry [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Tris(2-carboxyethyl)?phosphine hydrochloride. CAS No. 51805-45-9. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg; 1 g. Product ID: HY-W011500. | |
| TCEP Hydrochloride | TCEP Hydrochloride is used for selective reduction of disulfide bridges at low pH. Synonyms: TCEP.HCL; Tris(2-Carboxyethyl)Phosphine Hydrochloride; 3,3',3''-Phosphinetriyltripropanoic acid hydrochloride; TCEP HCl; TCEP; UNII-H49AAM893K; MFCD00145469; TCEP (hydrochloride); Tris(carboxyethyl)phosphine hydrochloride; H49AAM893K; Propanoic acid, 3,3',3''-phosphinidynetris-, hydrochloride. Grades: 98% (AT). CAS No. 51805-45-9. Molecular formula: C9H16ClO6P. Mole weight: 286.65. | |
| TCEP Hydrochloride | Biochemical tool for selective reduction of disulfide bridges at low pH; reductant for redox assay. Group: Biochemicals. Alternative Names: 3, 3', 3''-Phosphinidynetri spropanoic Acid Hydrochloride; Tris(2-carboxyethyl)phosphine Hydrochloride; Tris (carboxyethyl) phosphine Hydrochloride; TCEP·HCl. Grades: Highly Purified. CAS No. 51805-45-9. Pack Sizes: 1g, 5g, 25g. Molecular Formula: C9H15O6P. US Biological Life Sciences. | Worldwide |
| TCEP, Neutral | A ready-to-use stable, neutral form of the popular disulfide-reducing agent TCEP, Hydrochloride. Group: Fluorescence/luminescence spectroscopy. |  |
| TCF-1 | TCF-1. Uses: Designed for use in research and industrial production. Purity: 0.95. Product ID: ACMA00064460. Alfa Chemistry ISO 9001:2015 Certified. |  |
| TC-F 2 | TC-F 2. Group: Biochemicals. Grades: Purified. CAS No. 1304778-15-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-F 2 | TC-F 2 is a potent, reversible and noncovalent inhibitor of fatty acid amide hydrolase (FAAH) (IC50 = 28 and 100 nM for human and rat FAAH, respectively). Synonyms: 1-[(3S)-1-[4-(2-Benzofuranyl)-2-pyrimidinyl]-3-piperidinyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one. Grades: ≥99% by HPLC. CAS No. 1304778-15-1. Molecular formula: C26H25N5O2. Mole weight: 439.51. | |
| TCFH | A safe, affordable reagent for ester and difficult amide synthesis. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: Chloro-N,N,N,N-tetramethylformamidinium hexafluorophosphate. CAS No. 207915-99-9. |  Luxembourg Bio Technologies |
| TC-FPR 43 | TC-FPR 43 is a potent formyl peptide receptor 2 (FPR2) agonist (EC50 = 44 nM) that inhibits fMLP- and IL-8-induced neutrophil migration and induces calcium mobilization. TC-FPR 43 was shown to suppress inflammation in a mouse model of acute inflammation. It also acts as an ALX agonist. Synonyms: TCFPR43; TC FPR 43; TC-FPR-43; N-(4-Chlorophenyl)-N-[2,3-dihydro-1-methyl-5-(1-methylethyl)-3-oxo-2-phenyl-1H-pyrazol-4-yl]-urea; Pyrazolone, 1. Grades: ≥98% by HPLC. CAS No. 903895-98-7. Molecular formula: C20H21ClN4O2. Mole weight: 384.86. | |
| TC-FPR 43 | TC-FPR 43. Group: Biochemicals. Grades: Purified. CAS No. 903895-98-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1000 | TC-G 1000 is a potent and orally bioactive α2D-adrenoceptor agonist (Ki = 8.6 pM and 110 nM for rat α2D and α1 receptors respectively, and 25, 26 and 100 nM for human α2A, α2C and α2B receptors respectively). TC-G 1000 displays analgesic activity in a mouse model of abdominal irritation. Synonyms: TC-G 1000; TC G 1000; TCG 1000; TCG1000; 4-(6,7-Dihydro-1,3-dimethylbenzo[c]thien-4-yl)-1H-imidazole maleate. Grades: ≥98% by HPLC. CAS No. 245744-18-7. Molecular formula: C13H14N2S.C4H4O4. Mole weight: 346.4. | |
| TC-G 1000 | TC-G 1000. Group: Biochemicals. Grades: Purified. CAS No. 245744-18-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1001 | TC-G 1001. Group: Biochemicals. Grades: Purified. CAS No. 494191-73-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1001 | TC-G 1001 is a GPR35 agonist (pEC50 = 7.59 and 8.36 for β-arrestin and Gαq-i5 Ca2+ assays, respectively) displaying 1000-fold greater potency at human GPR35 receptors than mouse and rat GPR35 orthologs in an IP1 accumulation assay. Synonyms: TC-G 1001; TC G 1001; TCG 1001; TC-G-1001; TCG1001; 4-[[2-[(2-Fluorophenyl)amino]-4-oxo-5(4H)-thiazolylidene]methyl]benzoic acid. Grades: ≥98% by HPLC. CAS No. 494191-73-0. Molecular formula: C17H11FN2O3S. Mole weight: 342.34. | |
| TC-G 1003 | TC-G 1003. Group: Biochemicals. Grades: Purified. CAS No. 1021912-42-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-G 1003 | TC-G 1003 is a potent and high affinity somatostatin sst2 receptor agonist (Ki = 0.025 nM). TC-G 1003 exhibits an inhibitory effect on growth hormone secretion and attenuates laser-induced ocular neovascular lesion size in rats. Synonyms: TC-G1003; TC G1003; TCG1003; 3-[4-(3-Aminopropoxy)-7-chloro-3-(3,5-dimethylphenyl)-6-quinolinyl]phenol. Grades: ≥98% by HPLC. CAS No. 1021912-42-4. Molecular formula: C26H25ClN2O2. Mole weight: 432.94. | |
| TC-G 1004 | TC-G 1004. Group: Biochemicals. Grades: Purified. CAS No. 1061747-72-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1004 | TC-G 1004 is a potent and selective A2A antagonist. Synonyms: N-[2-(3,5-Dimethyl-1H-pyrazol-1-yl)-6-[6-(4-methoxy-1-piperidinyl)-2-pyridinyl]-4-pyrimidinyl]acetamide. CAS No. 1061747-72-5. Molecular formula: C22H27N7O2. Mole weight: 421.5. | |
| TC-G 1005 | TC-G 1005 is a potent and selective GPBA agonist (EC50 = 0.72 nM for hTGR5) that selectively activates TGR5 over FXR (farnesoid X receptor). TC-G 1005 has been shown to increase plasma GLP-1 level and lower blood glucose level in mice. Synonyms: TC-G 1005; TC G 1005; TCG 1005; TC-G-1005; TCG1005; (4-Cyclopropyl-3,4-dihydro-1(2H)-quinoxalinyl)[4-(2,5-dimethylphenoxy)-3-pyridinyl]methanone. Grades: ≥98% by HPLC. CAS No. 1415407-60-1. Molecular formula: C25H25N3O2. Mole weight: 399.48. | |
| TC-G 1006 | TC-G 1006. Group: Biochemicals. Grades: Purified. CAS No. 1324003-64-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G 1008 | TC-G 1008. Group: Biochemicals. Grades: Purified. CAS No. 1621175-65-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-G-1008 | TC-G-1008 (GPR39-C3) is a potent and orally available GPR39 agonist with EC50 values of 0.4 and 0.8 nM for rat and human receptors respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GPR39-C3. CAS No. 1621175-65-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-103007. | |
| TC-G-1008 | TC-G-1008, also known as GPR39-C3, is a potent and orally available GPR39 agonist (EC50= 0.4 and 0.8 nM for rat and human receptors respectively) with great selectivity for GPR39 over a panel of kinases (IC50s > 10 μM) and displays minimal binding affinity for ghrelin and neurotensin-1 receptors (IC50s > 30 μM). Synonyms: GPR39-C3, GPR39C3, GPR39 C3, TC-G-1008, TC-G1008, TC-G 1008, TCG-1008, TCG1008, TCG 1008; N- [3-chloro-4- [ [ [2- (methylamino) -6-pyridin-2-ylpyrimidin-4-yl] amino] methyl] phenyl] methanesulfonamide; GPR39-C3; N- (3-chloro-4- ( ( (2- (methylamino) -6- (2-pyridinyl) -4-pyrimidinyl) amino) methyl) phenyl) methanesulfonamide; TC-G 1008. CAS No. 1621175-65-2. Molecular formula: C18H19ClN6O2S. Mole weight: 418.9. | |
| TC-G 24 | TC-G 24 is a potent and brain penetrating GSK-3β inhibitor (IC50 = 17 nM) with selectivity for GSK-3β over CDK2 (22% inhibition at 10 μM). TC-G 24 has been shown to increase liver glycogen reserves in rodents. Synonyms: TC-G 24; TC G 24; TCG 24; TCG-24; TCG24; N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine. Grades: ≥98% by HPLC. CAS No. 1257256-44-2. Molecular formula: C15H11ClN4O3. Mole weight: 330.73. | |
| TC-G 24 | TC-G 24. Group: Biochemicals. Grades: Purified. CAS No. 1257256-44-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-H 106 | TC-H 106 is a slow, tight-binding inhibitor of class I HDAC, including HDAC 1, 2, and 3 with IC50 values of 150 nM , 760nM, and 370 nM, respectively. It demonstrats no activity against class II HDACs. It inhibits these enzymes through different mechanisms. It also has preference toward HDAC3 with K(I) of approximately 14 nm, 15 times lower than the K(I) for HDAC1. It exhibits weaker inhibitory activities against HDAC 8 with IC50 of 5 μM. It progressively binds HDACs and remains bound after wash-out. It may have therapeutic value in Friedrich's ataxia and Huntington's disease due to their low animal toxicity. Uses: Tc-h 106 may have therapeutic value in friedrich's ataxia and huntington's disease. Synonyms: TC-H 106, TC-H106, TC-H-106, TCH-106, TCH 106, TCH106, Histone Deacetylase Inhibitor VII; Pimelic Diphenylamide 106;N'-(2-aminophenyl)-N-(4-methylphenyl)heptanediamide;N1-(2-aminophenyl)-N7-(4-methylphenyl)-heptanediamide;RGFA-8;Histone Deacetylase Inhibitor VII. Grades: >99 %. CAS No. 937039-45-7. Molecular formula: C20H25N3O2. Mole weight: 339.43. | |
| TC-H 106 | TC-H 106. Group: Biochemicals. Grades: Purified. CAS No. 937039-45-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCH-165 | TCH-165 is a small molecule modulator of proteasome assembly, which increases 20S levels and facilitates 20S-mediated protein degradation[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1446350-60-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 500 mg. Product ID: HY-120722. | |
| TC HSD 21 | TC HSD 21 is a potent 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3) inhibitor (IC50 = 6 and 40 nM at human and mouse 17β-HSD3, respectively) with no activity at 17β-HSD1, 17β-HSD2, ERα, androgen receptors or glucocorticoid receptors. Synonyms: TC HSD 21; TC-HSD-21; TCHSD21; TC-HSD 21; 5-[(3-Bromo-4-hydroxyphenyl)methylene]-3-(4-methoxyphenyl)-2-thioxo-4-thiazolidinone. Grades: ≥99% by HPLC. CAS No. 330203-01-5. Molecular formula: C17H12BrNO3S2. Mole weight: 422.32. | |
| TC HSD 21 | TC HSD 21. Group: Biochemicals. Grades: Purified. CAS No. 330203-01-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC HSD 21 (5-[ (3-Bromo-4-hydroxyphenyl) methylene]-3- (4-methoxyphenyl) -2-thioxo-4-thiazolidinone) | Potent 17beta-hydroxysteroid dehydrogenase type 3 (17beta-HSD3) inhibitor (IC50 values are 6 and 40nm at human and mouse 17beta-HSD3 respectively). Displays no activity at 17beta-HSD1, 17beta-HSD2, ERalpha, androgen receptors or glucocorticoid receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 330203-01-5. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| TC-I 15 | TC-I 15 is a potent α2β1 integrin inhibitor (IC50 = 12 and 715 nM for the inhibition of human platelet adhesion to type I collagen and for platelets under static conditions and under flow, respectively), displaying selectivity for α2β1 over αvβ3, α5β1, α6β1 and αIIbβ3 at concentrations exceeding 1000 nM. TC-I 15 was shown to reduce collagen IV production in mesangial cells. Synonyms: TC-I 15; TCI 15; TC I 15; TCI15; N-[[ (4R)-5, 5-Dimethyl-3- (phenylsulfonyl)-4-thiazolidinyl]carbonyl]-3-[[[ (phenylmethyl)amino]carbonyl]amino]-L-alanine. Grades: ≥98% by HPLC. CAS No. 916734-43-5. Molecular formula: C23H28N4O6S2. Mole weight: 520.62. | |
| TC-I 15 | TC-I 15 (TC-I-15) is a type of allosteric collagen-binding integrin ?2?1 inhibitor, and it also inhibits ?1?1 and ?11?1. TC-I 15 inhibits platelet adhesion to collagen and thrombus deposition. TC-I 15 prevents the formation of a pre-metastatic microenvironment by inhibiting the uptake of cancer-associated fibroblast (CAF) extracellular vesicles (EVs) by lung fibroblasts, which reduces the metastasis of salivary gland adenocystic carcinoma (SACC) to the lungs in mouse models, [1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 916734-43-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-107588. | |
| TC-I 2000 | TC-I 2000 is a potent and orally bioactive TRPM8 channel blocker. TC-I 2000 was shown to inhibit icilin-induced TRPM8 channel activation in rTRPM8-expressing CHO cells (IC50 = 53 nM). Synonyms: TC-I2000; TC I 2000; TCI 2000; TCI2000; N-(4-Fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-2(1H)-isoquinolinecarboxamide; 2(1H)-Isoquinolinecarboxamide, N-(4-fluorophenyl)-3,4-dihydro-1-[4-(trifluoromethyl)phenyl]-; 1-(4-Trifluoromethyl-phenyl)-3,4-dihydro-1H-isoquinoline-2-carboxylic acid (4-fluoro-phenyl)-amide. Grades: ≥99% by HPLC. CAS No. 1159996-20-9. Molecular formula: C23H18F4N2O. Mole weight: 414.40. | |
| TC-I 2000 | TC-I 2000. Group: Biochemicals. Grades: Purified. CAS No. 1159996-20-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-I 2014 | TC-I 2014. Group: Biochemicals. Grades: Purified. CAS No. 1221349-53-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TC-I 2014 | TC-I 2014 is a potent TRPM8 antagonist (IC50 = 0.8, 3.0 and 4.4 nM for canine, human and rat channels, respectively) displaying antiallodynic properties in vivo. Synonyms: TC-I 2014; TC I 2014; TCI 2014; 3-[7-(Trifluoromethyl)-5-[2-(trifluoromethyl)phenyl]-1H-benzimidazol-2-yl]-1-oxa-2-azaspiro[4.5]dec-2-ene. Grades: ≥98% by HPLC. CAS No. 1221349-53-6. Molecular formula: C23H19F6N3O. Mole weight: 467.41. | |
| TCID | TCID is a DUB inhibitor for ubiquitin C-terminal hydrolase L3 with IC50 of 0.6 μM, 125-fold selective to L1. Synonyms: 4,5,6,7-Tetrachloroindan-1,3-dione; UCH-L3 Inhibitor. Grades: >98%. CAS No. 30675-13-9. Molecular formula: C9H2Cl4O2. Mole weight: 283.92. | |
| TCID | TCID. Group: Biochemicals. Grades: Purified. CAS No. 30675-13-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCID | TCID (4,5,6,7-Tetrachloroindan-1,3-dione) is a potent and selective neuronal ubiquitin C-terminal hydrolase (UCH-L3) inhibitor with an IC 50 of 0.6 μM [1]. TCID diminishes glycine transporter GlyT2 ubiquitination in brainstem and spinal cord primary neurons [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4,5,6,7-Tetrachloroindan-1,3-dione. CAS No. 30675-13-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-18638. | |
| TCID | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TC JL 37 | TC JL 37 is a potent and orally available inhibitor of tyrosine kinase 2 (TYK2, Ki = 1.6 nM). TC JL 37 inhibits IFNγ production in vivo in mice. Synonyms: TCJL-37; TCJL 37; TCJL37; TC JL-37; TC JL 37; TC JL37; 2-Chloro-4-cyano-6-fluoro-N-[2-[[[(1R,2R)-2-fluorocyclopropyl]carbonyl]amino]-4-pyridinyl]benzamide. Grades: ≥98% by HPLC. CAS No. 1258294-34-6. Molecular formula: C17H11ClF2N4O2. Mole weight: 376.74. | |
| TC KHNS 11 | TC KHNS 11 is a potent and selective PI 3-kinase δ inhibitor with preference for PI 3-Kδ over a panel of lipid and protein kinases. Synonyms: 5-[4-[3-[(4-Acetyl-1-piperazinyl)carbonyl]phenyl]-6-quinazolinyl]-2-methoxy-3-pyridinecarbonitrile. Grades: ≥98% by HPLC. CAS No. 1431540-99-6. Molecular formula: C28H24N6O3. Mole weight: 492.53. | |
| TCL053 | TCL053 is an ionizable lipid carrier and used to introduce active components, in particular nucleic acids, into cells with excellent efriciency. TCL053, together with DPPC (Dipalmitoylphosphatidylcholine), PEG-DMG (Polyethylene glycoldimyristoyl glycerol), and cholesterol, forms lipid nanoparticle (LNP) which is able to deliver Cas9 mRNA and sgRNA into skeletal muscle[1][2]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 2361162-70-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-147332. | |
| TC LPA5 4 | TC LPA5 4 is a LPA5 receptor antagonist (IC50 = 0.8 μM in LPA5-RH7777 cells), displaying selectivity for LPA5 against 80 other screened targets. TC LPA5 4 was shown to inhibit LPA-induced aggregation of isolated human platelets. Synonyms: LPA5-IN-4; LPA5-IN4; LPA5IN4, TC-LPA5-4; 5-(3-Chloro-4-cyclohexylphenyl)-1-(3-methoxyphenyl)-1H-pyrazole-3-carboxylic acid. Grades: ≥98% by HPLC. CAS No. 1393814-38-4. Molecular formula: C23H23ClN2O3. Mole weight: 410.89. | |
| TC LPA5 4 | TC LPA5 4 is a LPA 5 (GPR92) -specific non-lipid antagonist. TC LPA5 4 inhibits LPA-induced aggregation of isolated human platelet (LPA 5 -RH7777 cell line) with an IC 50 of 800 nM. TC LPA5 4 displays selectivity for LPA 5 over 80 other screened agent targets [1]. TC LPA5 4 inhibits cell proliferation and migration of thyroid cancer cells [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1393814-38-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-107615. | |
| TC LPA5 4 | TC LPA5 4. Group: Biochemicals. Grades: Purified. CAS No. 1393814-38-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TCLP Metals - Ash 1 | certified reference material, pkg of 225 g. Group: Application areas. | |
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