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| Product | Description | |
|---|---|---|
| TAK-063 | TAK-063 is a highly potent, selective, and orally active phosphodiesterase 10A (PDE10A) inhibitor. TAK-063 is currently being evaluated in clinical trials for the treatment of schizophrenia. Phosphodiesterase 10A (PDE10A) is a cAMP/cGMP phosphodiesterase highly expressed in medium spiny neurons (MSNs) in the striatum. TAK-063 represents a promising drug for the treatment of schizophrenia with potential for superior safety and tolerability profiles. Synonyms: TAK063, TAK 063, TAK-063, Balipodect. Grades: >98%. CAS No. 1238697-26-1. Molecular formula: C23H17FN6O2. Mole weight: 428.42. |  |
| TAK-070 | TAK-070, under the IUPAC name 2-Naphthaleneethanamin?e, 6-([1,?1'-biphenyl]?-4-ylmethoxy)?-1,?2,?3,?4-tetrahydro-N,?N-dimethyl-, hydrochloride, hydrate (1:1:1)?, (2R)?-, a novel noncompetitive BACE1 inhibitor, ameliorated Aβ pathology and behavioral deficits in Tg2576. Phase 1. Synonyms: TAK-070; TAK 070; TAK070; 2-Naphthaleneethanamin?e, 6-([1,?1'-biphenyl]?-4-ylmethoxy)?-1,?2,?3,?4-tetrahydro-N,?N-dimethyl-, hydrochloride, hydrate (1:1:1)?, (2R)?-; 2-Naphthaleneethanamine, 6-([1,1'-biphenyl]-4-ylmethoxy)-1,2,3,4-tetrahydro-N,N-dimethyl-, hydrochloride, monohydrate, (2R)- (9CI); UNII-EAC604ZY07; 365276-12-6. CAS No. 365276-12-6. Molecular formula: C27H31NO.HCl.H2O. Mole weight: 440.02. | |
| TAK-071 | TAK-071 is a novel, potent and highly selective muscarinic acetylcholine receptor 1 (M1R) positive allosteric modulator. EC 50 of TAK-071 M1R agonist activities is 520 nM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820812-16-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-122190. |  |
| TAK-071 | TAK-071 is a positive allosteric modulator of muscarinic acetylcholine receptor 1 (M1R). Uses: Muscarinic agonists. Synonyms: TAK-071; 1820812-16-5; UNII-59XC9G796Y; 59XC9G796Y; 4-Fluoro-2-((3S, 4S)-4-hydroxytetrahydro-2H-pyran-3-yl)-5-methyl-6-(4(1H-pyrazol-1-yl)benzyl)-2, 3-dihydro-1H-isoindol-1-one; L-Threo-pentitol, 1,5-anhydro-2,4-dideoxy-2-(4-fluoro-1,3-dihydro-5-methyl-1-oxo-6-((4-(1H-pyrazol-1-yl)phenyl)methyl)-2H-isoindol-2-yl)-; 4-fluoro-2-[(3S,4S)-4-hydroxyoxan-3-yl]-5-methyl-6-[(4-pyrazol-1-ylphenyl)methyl]-3H-isoindol-1-one; 6-(4-(1H-PYRAZOL-1-YL)BENZYL)-4-FLUORO-2-((3S,4S)-4-HYDROXYTETRAHYDRO-2H-PYRAN-3-YL)-5-METHYLISOINDOLIN-1-ONE; CHEMBL4594351; SCHEMBL17201222; GTPL12302; WFSARWQASFQZMG-VXKWHMMOSA-N; AKOS040739717; AC-31580; MS-27399; HY-122190; CS-0082523; D77973; 1,5-anhydro-2,4-dideoxy-2-(4-fluoro-5-methyl-1-oxo-6-(4-(1H-pyrazol-1-yl)benzyl)-1,3-dihydro-2H-isoindol-2-yl)-L-threo-pentitol; 4-fluoro-2-[(3s,4s)-4-hydroxytetrahydro-2h-pyran-3-yl]-5-methyl-6-[4-(1h-pyrazol-1-yl)benzyl]-2,3-dihydro-1h-isoindol-1-one. Grades: 98%. CAS No. 1820812-16-5. Molecular formula: C24H24FN3O3. Mole weight: 421.5. | |
| TAK 165 | TAK 165. Group: Biochemicals. Grades: Purified. CAS No. 366017-09-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| TAK1-IN-3 | TAK1-IN-3 is a potent ATP-competitive TAK1 inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 494772-87-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115743. | |
| TAK1-TAB1 (1-303), (437-end), active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| TAK 21d | TAK 21d is a potent and brain penetrating FAAH inhibitor (IC50 = 0.28 and 0.72 nM at rat and human FAAH, respectively). TAK 21d exhibits analgesic effects in vivo models of neuropathic and inflammatory pain. Synonyms: TAK-21d; TAK 21d; TAK21d; TAK-21-d; 4-[4-(3,4-Difluorophenyl)-2-pyrimidinyl]-N-3-pyridazinyl-1-piperazinecarboxamide. Grades: ≥98% by HPLC. CAS No. 1143578-94-2. Molecular formula: C19H17F2N7O. Mole weight: 397.38. | |
| TAK 21d | TAK 21d. Group: Biochemicals. Grades: Purified. CAS No. 1143578-94-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TAK-220 | TAK-220 is an orally bioavailable small-molecule CCR5 antagonist. Synonyms: TAK-220, TAK 220, TAK220; 1-acetyl-N-[3-[4-[(4-carbamoylphenyl)methyl]piperidin-1-yl]propyl]-N-(3-chloro-4-methylphenyl)piperidine-4-carboxamide. Grades: 99.95%. CAS No. 333994-00-6. Molecular formula: C31H41ClN4O3. Mole weight: 553.14. | |
| TAK-243 | TAK-243 Inhibitor. Uses: Scientific use. Product Category: T16974. CAS No. 1450833-55-2. |  |
| TAK-243 | TAK-243, a pyrazolopyrimidine derivative, has been found to be an Ubiquitin-protein ligase inhibitor and was just finished the Phase-I trial against solid tumors. Synonyms: TAK-243; TAK 243; TAK243; MLN7243; MLN-7243; MLN 7243; AOB87172; AOB-87172; AOB 87172. Grades: 98%. CAS No. 1450833-55-2. Molecular formula: C19H20F3N5O5S2. Mole weight: 519.51. | |
| TAK-243 | TAK-243 (MLN7243) is a first-in-class, selective ubiquitin activating enzyme, UAE (UBA1) inhibitor ( IC 50 =1 nM), which blocks ubiquitin conjugation, disrupting monoubiquitin signaling as well as global protein ubiquitination. TAK-243 (MLN7243) induces endoplasmic reticulum (ER) stress, abrogates NF-κB pathway activation and promotes apoptosis [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MLN7243. CAS No. 1450833-55-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-100487. | |
| TAK-259 HCl | This active molecular is a selective α1D Adrenergic Receptor antagonist. ( Ki value of 1.1 nM, 200 fold selective over α1A and 800 fold selective over α1B). TAK-259 exhibited a larger MRTpo value and potent antiurinary frequency efficacy. In Jul 2011, Phase-I clinical trials in Overactive bladder in Japan is on going. In Feb 2013, Phase-I for Overactive bladder in Japan was discontinued. Uses: Overactive bladder. Synonyms: TAK-259, TAK259, TAK259; 5-chloro-1-(5-chloro-2-(methylsulfonyl)benzyl)-2-imino-1,2-dihydropyridine-3-carboxamide hydrochloride,1192348-73-4 (free base). Grades: 98%. CAS No. 1192347-42-4. Molecular formula: C14H14Cl3N3O3S. Mole weight: 410.69. | |
| TAK-285 | TAK-285 is a novel dual erbB protein kinase inhibitor that specifically targets human epidermal growth factor receptor (EGFR) and HER2. Methods: TAK-285 is currently being developed by Takeda. TAK-285 was found to be well tolerate in Phase I trials. Absorption of TAK-285 was rapid after oral dosing, and plasma exposure at steady-state increased in a dose-proportional fashion for doses ranging from 50 to 300?mg b.i.d. A partial response was observed for one patient with parotid cancer who received 300?mg b.i.d. The toxicity profile and PK properties of oral TAK-285 warrant further evaluation. Synonyms: TAK285; TAK 285. CAS No. 871026-44-7. Molecular formula: C26H25ClF3N5O3. Mole weight: 547.963. | |
| TAK-438 | TAK-438 Inhibitor. Uses: Scientific use. Product Category: T2404. CAS No. 1260141-27-2. | |
| TAK-441 | TAK-441 is a highly potent and orally active hedgehog (Hh) signaling inhibitor with an IC 50 value of 4.4 nM. TAK-441 has strong antitumor activity in solid tumors [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186231-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16475. | |
| TAK-441 | TAK-441 is a potent inhibitor of Hedgehog (Hh) signaling pathway, TAK-441 is also a novel pyrrolo[3,2-c]quinoline-4-one derivative, which chemical structure is shown as the following. TAK-441 showed activity to suppress transcription factor Gli1 mRNA expression in tumor-associated stromal tissue and inhibited tumor growth (treatment/control ratio, 3%) in a mouse medulloblastoma allograft model owing to the improved PK profile based on increased solubility. TAK-441 is currently in clinical trials for the treatment of advanced solid tumors. Synonyms: TAK441; TAK 441. CAS No. 1186231-83-3. Molecular formula: C28H31F3N4O6. Mole weight: 576.57. | |
| TAK-448 | TAK-448 is a KISS1R protein agonist as a oligopeptide analog of kisspeptin. In animal model, TAK-448 can stimulate LH/FSH release, whereas continuous sc exposure rapidly down-regulates the pituitary-gonadal axis, with rapid reduction of T levels in a dose-dependent manner. Phase II clinical trials for the treatment of Prostate cancer was discontinued. In Dec 2016, Takeda terminated a phase II trial in Hypogonadism (In adults, In the elderly) in USA because the study did not meet the primary endpoints. Uses: Hypogonadism;prostate cancer. Synonyms: MVT-602; Ac-D-Tyr-D-Trp-Asn-Thr-Phe-azaGly-Leu-Arg(Me)-Trp-NH2; RVT-602; RVT 602; TAK 448; RVT602; TAK448; N-acetyl-D-tyrosyl-(4R)-4-hydroxy-L-prolyl-L-asparaginyl-L-threonyl-L-phenylalanyl-2-azaglycyl-L-leucyl-N5-(imino(methylamino)methyl)-L-ornithyl-L-Tryptophanamide; Istaroxime; (2S,5S,8S,14S,17S,20S)-20-[({(2S,4R)-1-[(2R)-2-Acetamido-3-(4-hydroxyphenyl)propanoyl]-4-hydroxy-2-pyrrolidinyl}carbonyl)amino]-14-benzyl-17-(1-hydroxyethyl)-2-(1H-indol-3-ylmethyl)-8-isobutyl-5-[3-(N'-methylcarbamimidamido)propyl]-4,7,10,13,16,19-hexaoxo-3,6,9,11,12,15,18-heptaazadocosane-1,22-diamide. Grades: 98%. CAS No. 1234319-68-6. Molecular formula: C58H80N16O14. Mole weight: 1225.36. | |
| TAK-475 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TAK-593 | TAK-593 is an oral formulation containing a small-molecule receptor tyrosine kinase inhibitor of both vascular endothelial growth factor receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) with potential antineoplastic activity. TAK-593 selectively binds to and inhibits VEGFR and PDGFR, which may result in the inhibition of angiogenesis and tumor cell proliferation. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TAK593; TAK 593. Grades: >98%. CAS No. 1005780-62-0. Molecular formula: C23H23N7O3. Mole weight: 445.483. | |
| TAK-603 | TAK-603, a quinoline derivative, has been found to be an immunomodulator that was once studied in sorts of inflammatory diseases. Synonyms: TAK-603, TAK603, TAK 603; Ethyl 4-(3,4-dimethoxyphenyl)-6,7-dimethoxy-2-(1,2,4-triazol-1-ylmethyl)quinoline-3-carboxylate; UNII-W6RZK26FCB; W6RZK26FCB; AC1L4BH6. Grades: 98%. CAS No. 158146-85-1. Molecular formula: C25H26N4O6. Mole weight: 478.51. | |
| TAK-632 | TAK-632 is a potent pan-RAF inhibitor with favorable in vitro activity (BRAF(V600E) IC50 value of 2.4 nM. Synonyms: TAK632, TAK 632, TAK-632. CAS No. 1228591-30-7. Molecular formula: C27H18F4N4O3S. Mole weight: 554.51. | |
| TAK-659 dihydrochloride | TAK-659 is a potent spleen tyrosine kinase (syk) inhibitor under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. TAK-659 may inhibit the activity of syk, which abrogates downstream BCR (B-cell receptor) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Phase I/II for the treatment Acute myeloid leukaemia, phase I for the treatment of Breast cancer, Gastrointestinal cancer, Head and neck cancer, Lymphoma, Non-small cell lung cancer and Solid tumours was on-going. Uses: Acute myeloid leukaemia;breast cancer; gastrointestinal cancer; head and neck cancer; lymphoma; non-small cell lung cancer; solid tumours most recent events. Synonyms: 6-(((1R,2S)-2-aminocyclohexyl)amino)-7-fluoro-4-(1-methyl-1H-pyrazol-4-yl)-1,2-dihydro-3H-pyrrolo[3,4-c]pyridin-3-one dihydrochloride; TAK659; TAK-659; TAK 659; TAK-659 HCl; TAK659 dihydrochloride. Grades: 98%. CAS No. 1312691-41-0. Molecular formula: C17H23Cl2FN6O. Mole weight: 417.31. | |
| TAK-659 hydrochloride | TAK-659 hydrochloride is a hydrochloride salt of TAK-659 which is a potent spleen tyrosine kinase (syk) inhibitor (IC50 = 3.2 nM) under the development of Takeda Oncology, with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Synonyms: TAK-659 hydrochloride; TAK 659 hydrochloride; TAK659 hydrochloride; 6-[[(1R,2S)-2-aminocyclohexyl]amino]-7-fluoro-4-(1-methylpyrazol-4-yl)-1,2-dihydropyrrolo[3,4-c]pyridin-3-one;hydrochloride; TAK-659 HCl. CAS No. 1952251-28-3. Molecular formula: C17H22ClFN6O. Mole weight: 380.85. | |
| TAK-683 | TAK-683 is an investigational peptide derivative of metastin under the development of Millennium. It is a KISS1R protein agonist. Phase I development for prostate cancer was discontinued. Uses: Prostate cancer. Synonyms: TAK-683, TAK 683, TAK683; (S)-2-((R)-2-((R)-2-acetamido-3-(4-hydroxyphenyl)propanamido)-3-(1H-indol-3-yl)propanamido)-N1-((8S,11S,17S,20S,21R)-8-(((S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl)carbamoyl)-17-benzyl-21-hydroxy-3-imino-11-isobutyl-10,13,16,19-tetraoxo-2,4,9,12,14,15,18-heptaazadocosan-20-yl)succinamide. Grades: 98%. CAS No. 872719-49-8. Molecular formula: C64H83N17O13. Mole weight: 1298.47. | |
| TAK-700 | TAK-700 (Orteronel) is a potent and highly selective human 17,20-lyase inhibitor with IC50 of 38 nM, exhibits >1000-fold selectivity over other CYPs (e.g. 11-hydroxylase and CYP3A4). It completed two phase III clinical trials for metastatic, hormone-refractory prostate cancer but failed to extend overall survival rates, and development was voluntarily terminated as a result. Synonyms: TAK-700; TAK700; (S/R)-Orteronel; 6-(7-hydroxy-6,7-dihydro-5H-pyrrolo[1,2-c]imidazol-7-yl)-N-methyl-2-naphthamide. Grades: >98%. CAS No. 426219-18-3. Molecular formula: C18H17N3O2. Mole weight: 307.35. | |
| TAK 715 | TAK 715. Group: Biochemicals. Grades: Purified. CAS No. 303162-79-0. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TAK-715 | TAK-715 is a p38 MAPK inhibitor for p38α with IC50 of 7.1 nM, 28-fold more selective for p38α over p38β, no inhibition to p38γ/δ, JNK1, ERK1, IKKβ, MEKK1 or TAK1. Synonyms: TAK715, TA 715, TAK715. Grades: 0.99. CAS No. 303162-79-0. Molecular formula: C24H21N3OS. Mole weight: 399.512. | |
| TAK-715 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TAK-733 | TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. MEK inhibitor TAK-733 selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and are often upregulated in a variety of tumor cell types. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TAK 733; TAK733. Grades: >98%. CAS No. 1035555-63-5. Molecular formula: C17H15F2IN4O4. Mole weight: 504.232. | |
| TAK-779 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| TAK-779 | TAK-779 is a potent, dual antagonist at chemokine receptors CCR2 and CCR5 with IC50=1.4 nM at CCR5 and 2.3 nM at CCR2. Antagonists of both CCR2 and CCR5 such as TAK-779 have been investigated for treatment of viruses, rheumatoid arthritis, multiple sclerosis, and cancer. CCR5 is particularly targeted for anti-HIV therapy, since HIV entry into cells requires chemokine coreceptors CCR5 and CXCR4. Synonyms: N,N-Dimethyl-N-[4-[[[2-(4-methylphenyl)-6,7-dihydro-5H-benzohepten-8-yl]carbonyl]amino]benzyl]tetrahydro-2H-pyran-4-aminium chloride, TAK-799; TAK 779; TAK779; Takeda 779. Grades: >98%. CAS No. 229005-80-5. Molecular formula: C33H39ClN2O2. Mole weight: 531.13. | |
| Tak875 | Tak875. Uses: Designed for use in research and industrial production. Additional or Alternative Names: TAK875;3-Benzofuranacetic acid, 6-[[2,6-diMethyl-4-[3-(Methylsulfonyl)propoxy][1,1-biphenyl]-3-yl]Methoxy]-2,3-dihydro-, (3S)-;(3S)-6-[[2,6-Dimethyl-4-[3-(methylsulfonyl)propoxy][1,1-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid;TAK-875,TAK875;[(3S)-6-({2,6-Dimethyl-4-[3-(methylsulfonyl)propoxy]-3-biphenylyl}methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid;(S)-2-(6-((2,6-Dimethyl-4-(3-(methylsulfonyl)propoxy)-[1,1-biphenyl]-3-yl)methoxy)-2,3-dihydrobenzofuran-3-yl)acetic acid;TAK-875, >=98%;Fasiglifam. CAS No. 1000413-72-8. Molecular formula: C29H32O7S. Mole weight: 524.62518. Purity: 99%+. IUPACName: 2-[(3S)-6-[[3-[2,6-dimethyl-4-(3-methylsulfonylpropoxy)phenyl]phenyl]methoxy]-2,3-dihydro-1-benzofuran-3-yl]aceticacid. Canonical SMILES: CC1=CC(=CC(=C1C2=CC(=CC=C2)COC3=CC4=C(C=C3)C(CO4)CC(=O)O)C)OCCCS(=O)(=O)C. Density: 1.252. Product ID: ACM1000413728. Alfa Chemistry ISO 9001:2015 Certified. Categories: TAK375. |  |
| TAK-875 | TAK-875 is a potent, selective, and orally bioavailable GPR40 agonist, with a pharmacokinetic profile enabling long-acting drug efficacy. Synonyms: TAK875; TAK 875; Fasiglifam; 3-Benzofuranacetic acid, 6-[[2',6'-dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-, (3S)-; (3S)-6-[[2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy][1,1'-biphenyl]-3-yl]methoxy]-2,3-dihydro-3-benzofuranacetic acid; (+)-TAK 875; (3S)-6-([2',6'-Dimethyl-4'-[3-(methylsulfonyl)propoxy]biphenyl-3-yl]methoxy)-2,3-dihydro-1-benzofuran-3-yl]acetic acid. Grades: >98%. CAS No. 1000413-72-8. Molecular formula: C29H32O7S. Mole weight: 524.63. | |
| TAK-875 Hemihydrate | TAK-875 is a novel, orally available, selective GPR40 agonist. TAK-875 exhibits potent agonist activity and high binding affinity to the human GPR40 receptor with Ki of 38 nM. TAK-875 enhanced glucose-induced insulin secretion in a glucose-dependent manner in both human and rat islets. In rat insulinoma INS-1 833/15 cells, TAK-875 increased intracellular inositol monophosphate and calcium concentration, consistent with activation of the Gqα signaling pathway. In addition, TAK-875 (10 mg/kg, p.o.) significantly augmented plasma insulin levels and reduced fasting hyperglycemia in male Zucker diabetic fatty rats, whereas in fasted normal Sprague-Dawley rats, TAK-875 neither enhanced insulin secretion nor caused hypoglycemia even at 30 mg/kg. TAK-875 improves both postprandial and fasting hyperglycemia with a low risk of hypoglycemia and no evidence of β cell toxicity. TAK-875 significantly improved glycaemic control in patients with type 2 diabetes with minimum risk of hypoglycaemia. Synonyms: Fasiglifam hemihydrate; TAK875 hemihydrate; (3S)-6-((2',6'-Dimethyl-4'-(3-(methylsulfonyl)propoxy) biphenyl-3-yl)methoxy)-2,3-dihydro-l-benzofuran-3-yl)acetic acid hemihydrate. Grades: 98%. CAS No. 1374598-80-7. Molecular formula: C58H66O15S2. Mole weight: 1067.27. | |
| TAK-901 | TAK-901 is a multi-targeted aurora inhibitor with IC50s of 21 and 15 nM for aurora A and B, respectively. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 934541-31-8. Molecular formula: C28H32N4O3S. Mole weight: 504.6458. Purity: 0.96. Product ID: ACM934541318. Alfa Chemistry ISO 9001:2015 Certified. Categories: TAK-919. | |
| TAK-901 | TAK-901 is a small-molecule inhibitor of the serine-threonine kinase Aurora B with potential antineoplastic activity. Aurora B kinase inhibitor TAK-901 binds to and inhibits the activity of Aurora B, which may result in a decrease in the proliferation of tumor cells that overexpress Aurora B. Aurora B is a positive regulator of mitosis that functions in the attachment of the mitotic spindle to the centromere; the segregation of sister chromatids to each daughter cell; and the separation of daughter cells during cytokinesis. This serine/threonine kinase may be amplified and overexpressed by a variety of cancer cell types. Check for active clinical trials or closed clinical trials using this agent. Synonyms: TAK901, TAK-901, TAK 901. Grades: >98%. CAS No. 934541-31-8. Molecular formula: C28H32N4O3S. Mole weight: 504.64. | |
| TAK-901 | TAK-901. Group: Biochemicals. Alternative Names: 5-[3-(Ethylsulfonyl)phenyl]-3,8-dimethyl-N-(1-methyl-4-piperidinyl)-9H-pyrido[2,3-b]indole-7-carboxamide. Grades: Highly Purified. CAS No. 934541-31-8. Pack Sizes: 1mg, 2mg, 5mg, 10mg, 25mg. Molecular Formula: C28H32N4O3S. US Biological Life Sciences. | Worldwide |
| TAK-960 | TAK-960 is an orally available, selective inhibitor of polo-like kinase 1 (PLK1) , with an IC 50 of 0.8 nM. TAK-960 also shows inhibitory activities against PLK2 and PLK3, with IC 50 s of 16.9 and 50.2 nM, respectively. TAK-960 inhibits proliferation of multiple cancer cell lines and exhibits significant efficacy against multiple tumor xenografts [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1137868-52-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15160. | |
| TAK-960 | TAK-960 is an orally available PLK1 inhibitor with potential antineoplastic activity. Polo-like kinase 1 inhibitor TAK-960 selectively inhibits PLK1, inducing selective G2/M cell-cycle arrest followed by apoptosis in a variety of tumor cells while causing reversible cell-cycle arrest at the G1 and G2 stages without apoptosis in normal cells. PLK1 inhibition may result in the inhibition of proliferation in PLK1-overexpressed tumor cells. PLK1, named after the polo gene of Drosophila melanogaster, is a serine/threonine kinase crucial in the regulation of mitosis. Synonyms: TAK 960; TAK960. CAS No. 1137868-52-0. Molecular formula: C27H34F3N7O3. Mole weight: 561.61. | |
| TAK-960-d3 | TAK-960-d3. Group: Biochemicals. Alternative Names: 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide-d3. Grades: Highly Purified. Pack Sizes: 1mg. Molecular Formula: CH31D3F3N7O3, Molecular Weight: 564.62. US Biological Life Sciences. | Worldwide |
| TAK-960 dihydrochloride | TAK-960 is an orally available, potent and selective PLK1 inhibitor that was in a phase I clinical trial in patients with advanced non-hematologic malignancies. Synonyms: 4-[(9-cyclopentyl-7,7-difluoro-5-methyl-6-oxo-8H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methylpiperidin-4-yl)benzamide;dihydrochloride; TAK-960 (dihydrochloride); TAK 960 (dihydrochloride); TAK960 (dihydrochloride). Molecular formula: C27H36Cl2F3N7O3. Mole weight: 634.52. | |
| TAK 960 hydrochloride | TAK 960 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1137868-96-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| TAK-960 hydrochloride | The hydrochloride salt form of TAK-960, a newly studied selective PLK1 inhibitor, might have potential effect in inhibiting proliferation of sorts of cancer cell lines in vitro. The Phase-I was already discontinued for Solid tumours in USA. IC50: 1.5 nM. Uses: The hydrochloride salt form of tak-960 is a newly studied selective plk1 inhibitor and might have potential effect in inhibiting proliferation of sorts of cancer cell lines. Synonyms: TAK-960 (hydrochloride); TAK 960 hydrochloride; TAK960 hydrochloride; HY-15160A; AKOS025147360; 1137868-96-2; 4-[(9-Cyclopentyl-7,7-difluoro-6,7,8,9-tetrahydro-5-methyl-6-oxo-5H-pyrimido[4,5-b][1,4]diazepin-2-yl)amino]-2-fluoro-5-methoxy-N-(1-methyl-4-piperidinyl)benzamide hyd. Grades: 98%. CAS No. 1137868-96-2. Molecular formula: C27H35ClF3N7O3. Mole weight: 598.06. | |
| Taka-Diastase from Aspergillus oryzae | powder, slightly beige, ~100 U/mg. Group: Fluorescence/luminescence spectroscopy. | |
| Takanawaene A | Takanawaene A is a pentaene macrolide antibiotic produced by Streptomyces sp. K99-5278. It inhibits the growth of Saccharomyces cerevisiae with IC50 of 21.8 μmol/L. Synonyms: Fungicide K 99-5278A. CAS No. 627509-56-2. Molecular formula: C30H48O8. Mole weight: 536.70. | |
| Takanawaene B | Takanawaene B is a pentaene macrolide antibiotic produced by Streptomyces sp. K99-5278. It has the activity of inhibiting the growth of Aspergillus niger, Mucor raceme, Candida albicans and Saccharomyces cerevisiae, with IC50 of 0.94, 44.3, 177.0 and 20.9 μmol/L, respectively. CAS No. 627509-57-3. Molecular formula: C32H52O8. Mole weight: 564.75. | |
| Takanawaene C | Takanawaene C is a pentaene macrolide antibiotic produced by Streptomyces sp. K99-5278. It inhibits the growth of Saccharomyces cerevisiae with IC50 of 28.7 μmol/L. CAS No. 627509-58-4. Molecular formula: C33H54O8. Mole weight: 578.77. | |
| Takinib | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Takinib | Takinib Inhibitor. Uses: Scientific use. Product Category: T4264. CAS No. 1111556-37-6. | |
| Takinib | Takinib is a potent and selective TAK1 inhibitor with IC50 value of 9.5 nM. It induces apoptosis following TNF-α stimulation in cell models of rheumatoid arthritis and metastatic breast cancer. Synonyms: EDHS-206; GTPL9655; 3-N-(1-propylbenzimidazol-2-yl)benzene-1,3-dicarboxamide. CAS No. 1111556-37-6. Molecular formula: C18H18N4O2. Mole weight: 322.36. | |
| Talabostat | Talabostat, also called as PT100 or Val-boroPro, is a potent, nonselective and orally available dipeptidyl peptidase IV(DPP-IV) inhibitor (Ki= 0.18 nM) with antineoplastic and hematopoiesis- stimulating activities. Synonyms: [(2R)-1-[(2S)-2-amino-3-methylbutanoyl]pyrrolidin-2-yl]boronic acid; L-valinyl-L-boroproline; PT 100; PT-100; PT100 cpd; talabostat; valinyl-boroproline. CAS No. 149682-77-9. Molecular formula: C9H19BN2O3. Mole weight: 214.07. | |
| Talabostat mesylate | Talabostat mesylate (Val-boroPro mesylate; PT100 mesylate) is an orally active and nonselective dipeptidyl peptidase IV (DPP-IV) inhibitor ( IC 50 < 4 nM; K i = 0.18 nM) and the inhibitor of fibroblast activation protein (FAP) ( IC 50 = 560 nM), inhibits DPP8/9 ( IC 50 = 4/11 nM; K i = 1.5/0.76 nM), quiescent cell proline dipeptidase (QPP) ( IC 50 = 310 nM), DPP2, and some other DASH family enzymes. Antineoplastic and hematopoiesis- stimulating activities [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Val-boroPro mesylate; PT100 mesylate. CAS No. 150080-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-13233A. | |
| Talabostat mesylate | Talabostat mesylate is the orally bioavailable mesylate salt of an amino boronic dipeptide with antineoplastic and hematopoiesis- stimulating activities. By cleaving N-terminal Xaa-Pro or Xaa-Ala residues, talabostat inhibits dipeptidyl peptidases, such as fibroblast activation protein (FAP), resulting in the stimulation of cytokine and chemokine production and specific T-cell immunity and T-cell- dependent activity. This agent may also stimulate the production of colony stimulating factors, such as granulocyte colony stimulating factor (G-CSF), resulting in the stimulation of hematopoiesis. Dipeptidyl peptidases are involved in the activation of polypeptide hormones and chemokines. Uses: For research used only. Synonyms: (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid (1:1); PT-100; PT100; PT 100; D05989; D-05989; D 05989; Val-boro-pro; Talabostat. Grades: 98%. CAS No. 150080-09-4. Molecular formula: C10H23BN2O6S. Mole weight: 310.17. | |
| Talacotuzumab | Talacotuzumab (JNJ 56022473; CSL 362) is an IgG1-type fully humanized, CD123 -neutralizing monoclonal antibody containing a modified Fc structure. Talacotuzumab has K D s of 0.43 nM, 188 nM, 46 nM, 16.8 nM for CD123, CD32b/c, CD16-158F, CD16-158V, respectively. Talacotuzumab inhibits IL-3 binding to CD123, antagonizing IL-3 signaling in target cells. Talacotuzumab has mutated the Fc region to increase affinity for CD16 (FcγRIIIa), thereby enhancing antibody-dependent cell-mediated cytotoxicity (ADCC). Talacotuzumab is highly effective in vivo reducing leukemic cell growth in acute myeloid leukemia (AML) xenograft mouse models [1] [2] [3] [4]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: JNJ 56022473; CSL 362. CAS No. 1826831-79-1. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99395. | |
| Taladegib | Taladegib is an inhibitor of Smoothened (Smo) receptor and potently inhibits Hedgehog (Hh) signaling. It inhibits cell growth and proliferation in tumor cell lines. Synonyms: 4-fluoro-N-methyl-N-(1-(4-(1-methyl-1H-pyrazol-5-yl)phthalazin-1-yl)piperidin-4-yl)-2-(trifluoromethyl)benzamide; LY2940680; LY 2940680; LY-2940680. Grades: >98%. CAS No. 1258861-20-9. Molecular formula: C26H24F4N6O. Mole weight: 512.5. | |
| Taladegib | Taladegib (LY2940680) is an antagonist of the smoothened receptor. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LY2940680. CAS No. 1258861-20-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13242. | |
| Talampanel | Talampanel. Group: Biochemicals. Grades: Purified. CAS No. 161832-65-1. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Talampanel | ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Talampanel | Talampanel (LY300164) is an orally and selective α-amino-3-hydroxy-5-methyl-4-isoxazolepropionate (AMPA) receptor antagonis with anti-seizure activity [1]. Talampanel (IVAX) has neuroprotective effects in rodent stroke models [2]. Talampanel attenuates caspase-3 dependent apoptosis in mouse brain [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GYKI-53773; LY-300164. CAS No. 161832-65-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15079. | |
| Talampanel | Talampanel, also known as LY300164 and GYKI-53773, is a glutamate receptor inhibitor with anti-seizure activity. Talampanel is also an orally active, potent and selective AMPA-receptor antagonist, and can noncompetitively bind to the AMPA subtype of glutamate excitatory amino acid receptors and may inhibit the growth of gliomas by interfering with neurotransmitters involved in brain tumor growth. This agent may also protect against traumatic brain injury. Talampanel (GYKI 53405) is being investigated for the treatment of epilepsy, malignant gliomas and amyotrophic lateral sclerosis (ALS). As of May 2010, results from the trial for ALS have been found negative. Synonyms: LY300164; LY 300164; LY-300164; GYKI-53773; Gyki 53405; Gyki53405; Gyki-53405; LY293606; LY-293606; LY 293606. Grades: >98%. CAS No. 161832-65-1. Molecular formula: C19H19N3O3. Mole weight: 337.37. | |
| Talampicillin Hydrochloride | The hydrochloride salt form of Talampicillin, which is a penicillin-like antibiotic and used as the predrug of ampicillin. Uses: Anti-bacterial agents. Synonyms: (3-oxo-1H-2-benzofuran-1-yl) (2S,5R,6R)-6-[(2-amino-2-phenylacetyl)amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate;hydrochloride. Grades: > 95%. CAS No. 39878-70-1. Molecular formula: C24H23N3O6S. HCl. Mole weight: 517.98. | |
| Talaporfin sodium | Talaporfin sodium is a natural chlorophyll-based, and water soluble PDT photosensitizer consisting of chlorin e6, derived from chlorophyll, and L-aspartic acid with photosensitizing activity. After intratumoral activation by light emitting diodes, talaporfin sodium forms an extended high energy conformational state that generates singlet oxygen, which can kill target tissues with minimal side effects through vascular closure and apoptosis. Constant illumination can activate each molecule of talaporfin many times, resulting in a continuous supply of singlet oxygen molecules. Talaporfin kills all tumour cells in the targeted zone, rather than only the minority of cells undergoing rapid division, as in the case of chemotherapy. There are no serious toxicities to date. Talaporfin sodium was approved in 2004 in Japan, and is currently in phase III trials in USA. Synonyms: LS11, LS-11, LS 11, ME2906, ME 2906, ME-2906, NPe6; mono-L-aspartyl chlorin e6; Laserphyrin; Mono-L-aspartyl chlorin e6; LS-11; ME-2906. Grades: >98%. CAS No. 220201-34-3. Molecular formula: C38H37N5Na4O9. Mole weight: 799.69. | |
| Talaporfin sodium | Talaporfin (ME2906) sodium is a chlorin based photosensitizer. Talaporfin sodium can be used for the research of various cancers by using photodynamic therapy (PDT) [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ME2906; Mono-L-aspartyl chlorin e6; NPe6. CAS No. 220201-34-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16477. | |
| Talaromycesone A | Talaromycesone A is a fungal metabolite originally isolated from Talaromyces. It is active against S. epidermidis and methicillin-resistant S. aureus (MRSA) bacteria (IC50s = 3.70 and 5.48 μM, respectively). Talaromycesone A inhibits acetylcholinesterase (AChE) in a cell-free assay (IC50 = 7.49 μM for the human enzyme). Synonyms: Talaromycesone A; 1658474-60-2; (8S,8aS,15aR,15bR,16S)-16-(acetyloxy)-8,8a,15,15a-tetrahydro-4,11,14-trihydroxy-8a-methoxy-6,9-dimethyl-7H-8,15b-methano-1H,3H,12H-benzo[de]cyclohepta[1,2-g:3,4,5-d'e']bis[2]benzopyran-3,7,12-trione; AKOS040756377. Grades: >95% by HPLC. CAS No. 1658474-60-2. Molecular formula: C29H24O11. Mole weight: 548.49. | |
| Talarozole | Talarozole (R115866) is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA) which increases intracellular levels of endogenous all-trans retinoic acid (RA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC 50 s of 5.4 and 0.46 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: R115866. CAS No. 201410-53-9. Pack Sizes: 10 mM * 1 mL; 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14531. | |
| Talarozole | Talarozole, a retinoic acid metabolism blocking agent (RAMBA), is a potent and selective inhibitor of cytochrome P450 26 to treat dermatalogical diseases including psoriasis and acne. Synonyms: N-[4-[2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl]-2-benzothiazolamine; Rambazole; R 115866; R-115866; R115866. Grades: ≥95%. CAS No. 201410-53-9. Molecular formula: C21H23N5S. Mole weight: 377.50. | |
| Talatisamine | Talatisamine, a aconitum alkaloid, is specific K + channel blocker. Talatisamine attenuates beta-amyloid oligomers induced neurotoxicity in cultured cortical neurons [1]. Uses: Scientific research. Group: Natural products. CAS No. 20501-56-8. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N0663. | |
| Talatisamine | Talatisamine. Group: Biochemicals. Alternative Names: Talatizamine. Grades: Plant Grade. CAS No. 20501-56-8. Pack Sizes: 10mg. Molecular Formula: C24H39NO5, Molecular Weight: 421.57. US Biological Life Sciences. | Worldwide |
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