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| Product | Description | |
|---|---|---|
| Ultra Thin Tellurium Nanofoil | Ultra Thin Tellurium Nanofoil. Group: Nanofoil. CAS No. 13494-80-9. [Te]. |  |
| Ultra Thin Terbium Nanofoil | Ultra Thin Terbium Nanofoil. Group: Nanofoil. Molecular formula: 158.93. [Tb]. | |
| Ultra Thin Thulium Nanofoil | Ultra Thin Thulium Nanofoil. Group: Nanofoil. CAS No. 7440-30-4. Molecular formula: 168.93. [Tm]. | |
| Ultra Thin Tin Foil | Ultra Thin Tin Foil. Group: Nanofoil. CAS No. 7440-31-5. Molecular formula: 118.69. [Sn]. | |
| Ultra Thin Vanadium Nanofoil | Ultra Thin Vanadium Nanofoil. Group: Nanofoil. CAS No. 7440-62-2. Molecular formula: 163. [V]. | |
| Ultra Thin Ytterbium Nanofoil | Ultra Thin Ytterbium Nanofoil. Group: Nanofoil. CAS No. 7440-64-4. Molecular formula: 173.04. [Yb]. | |
| Ultra Thin Yttrium Nanofoil | Ultra Thin Yttrium Nanofoil. Group: Nanofoil. CAS No. 7440-65-5. Molecular formula: 88.9g/mol. Mole weight: Y. [Y]. | |
| Ultravanil | Ultravanil. CAS No. MIXTURE. VIGON Item # 503254. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. |  America & Internationally |
| Ultraviolet AbsorbentUV-234 | DryPowder; OtherSolid. Group: Polymers. CAS No. 70321-86-7. Product ID: 2-(benzotriazol-2-yl)-4,6-bis(2-phenylpropan-2-yl)phenol. Molecular formula: 447.6g/mol. Mole weight: C30H29N3O. CC (C) (C1=CC=CC=C1)C2=CC (=C (C (=C2)N3N=C4C=CC=CC4=N3)O)C (C) (C)C5=CC=CC=C5. InChI=1S/C30H29N3O/c1-29 (2, 21-13-7-5-8-14-21)23-19-24 (30 (3, 4)22-15-9-6-10-16-22)28 (34)27 (20-23)33-31-25-17-11-12-18-26 (25)32-33/h5-20, 34H, 1-4H3. OLFNXLXEGXRUOI-UHFFFAOYSA-N. | |
| Ultraviolet absorbent uv-p | DryPowder; OtherSolid. Group: Plastic additives. CAS No. 2440-22-4. Product ID: 2-(benzotriazol-2-yl)-4-methylphenol. Molecular formula: 225.25g/mol. Mole weight: C13H11N3O. CC1=CC(=C(C=C1)O)N2N=C3C=CC=CC3=N2. InChI=1S/C13H11N3O/c1-9-6-7-13 (17)12 (8-9)16-14-10-4-2-3-5-11 (10)15-16/h2-8, 17H, 1H3. MCPKSFINULVDNX-UHFFFAOYSA-N. | |
| Ultraviolet absorbent uv-p | DryPowder; OtherSolid. Group: Heterocyclic organic compound. CAS No. 2440-22-4. Molecular formula: C13H11N3O. Mole weight: 225.25g/mol. Purity: N/A. IUPACName: 2-(benzotriazol-2-yl)-4-methylphenol. Canonical SMILES: CC1=CC(=C(C=C1)O)N2N=C3C=CC=CC3=N2. ECNumber: 219-470-5;607-063-9. Catalog: ACM2440224. |  |
| Ultrazur ® | Ultrazur ®. CAS No. MIXTURE. VIGON Item # 502682. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers. | America & Internationally |
| Ulvan polysaccharide |  | |
| Ulvan - Ulva armoricana-winter-heavy | Cas No. 164252-34-0. | |
| Ulvan - Ulva rotondata-Autumn | Ulvan - Ulva rotondata-Autumn, originating from the autumnal Ulva rotondata, showcases great application in studying a multitude of ailments, encompassing cancer, diabetes and cardiovascular maladies alike. Synonyms: Sulfated xylorhamnoglycuronan; Ulvan MW. Molecular formula: (C6H9O3SO3)n. | |
| Ulvan - Ulva rotondata-Summer | Ulvan, derived from the Ulva rotondata-Summer algae, is a remarkable natural polysaccharide. This bioactive compound exhibits immense application as a compound owing to its multifaceted anti-inflammatory and antioxidant characteristics. Synonyms: Sulfated xylorhamnoglycuronan; Ulvan MW. Molecular formula: (C6H9O3SO3)n. | |
| UM-164 | UM-164 is an inhibitor of Src and p38 MAPK kinases with Kds values of 2.7, 2.2, and 5.5 nM for c-Src, p38α, and p38β, respectively. It inhibits cell growth in a panel of triple-negative breast cancer (TNBC) cell lines (IC50s = 6.1-260 nM) and in a patient-derived TNBC cell line (IC50 = 320 nM). Uses: Protein kinase inhibitors. Synonyms: DAS-DFGO-II; 2-[[6-[4- (2-hydroxyethyl) piperazin-1-yl]-2-methylpyrimidin-4-yl]amino]-N-[2-methyl-5-[[3- (trifluoromethyl) benzoyl]amino]phenyl]-1, 3-thiazole-5-carboxamide. Grades: ≥98%. CAS No. 903564-48-7. Molecular formula: C30H31F3N8O3S. Mole weight: 640.68. | |
| UMB-32 | UMB-32 is an inhibitor of the BET bromodomain BRD4 (Kd = 550 nM; IC50 = 637 nM) and the bromodomain-containing transcription factor TAF1 (Kd = 560 nM) and TAF1L (Kd = 1.3 μM). Synonyms: N-Tert-Butyl-2-[4-(3,5-Dimethyl-1,2-Oxazol-4-Yl)phenyl]imidazo[1,2-A]pyrazin-3-Amine. Grades: ≥98%. CAS No. 1635437-39-6. Molecular formula: C21H23N5O. Mole weight: 361.4. | |
| UMB 68 | UMB 68 is a GHB receptor ligand exhibiting no affinity for GABA(A) or GABA(B) receptors. UMB 68 was shown not to exhibit GHB-like behavioral effects in vivo. Synonyms: UMB68, UMB-68, UMB 68, UMB-68 sodium; Sodium 4-Hydroxy-4methylpentanoate. CAS No. 581099-89-0. Molecular formula: C6H11NaO3. Mole weight: 154.14. | |
| Umbelliferone | Umbelliferone (7-Hydroxycoumarin), a natural orally active product of the coumarin family, is a fluorescing compound which can be used as a sunscreen agent. Umbelliferone induces cell cycle arrest, apoptosis and DNA fragmentation in HepG2 cells. Umbelliferone exhibits significant anticancer effects. Umbelliferone attenuates the alteration characteristics of allergic airway inflammation. Umbelliferone displays the neuroprotective effects and cross the blood-brain barrier. Umbelliferone exhibits anti-inflammatory and antioxidant effects in chronic alcohol-fed rats [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. Alternative Names: 7-Hydroxycoumarin; Hydrangin; NSC 19790. CAS No. 93-35-6. Pack Sizes: 10 mM * 1 mL; 100 mg. Product ID: HY-N0573. |  |
| Umbelliferone | Umbelliferone, which is extracted from the root of Angelica biserrata (Shan et Yuan) Yuan et Shan, also known as 7-hydroxycoumarin, hydrangine, skimmetine, and beta-umbelliferone, is a widespread natural product of the coumarin family. It is a yellowish-white crystalline solid that has a slight solubility in hot water, but high solubility in ethanol. Uses: Anti-nociceptive, anti-inflammatory,anti-cancer, anti-oxidant. Synonyms: 7-hydroxy-1-benzopyran-2-one;7-Hydroxycoumarin. Grades: >98%. CAS No. 93-35-6. Molecular formula: C9H6O3. Mole weight: 162.1. | |
| Umbelliferone 7-O-Rutinoside | An impurity of Umbelliferone. Umbelliferone is a metabolite of Coumarin. Umbelliferone is used as a sunscreen agent for its ultraviolet activity. CAS No. 135064-04-9. Molecular formula: C21H26O13. Mole weight: 486.43. | |
| Umbelliferone 99+% (HPLC) | Umbelliferone 99+% (HPLC). Group: Biochemicals. Grades: Reagent Grade. CAS No. 93-35-6. Pack Sizes: 100g, 250g, 25g, 1Kg. US Biological Life Sciences. |  Worldwide |
| Umbelliprenin | Umbelliprenin, a prenylated coumarin, is an antioxidant with anticancer, anti-inflammatory and immunomodulatory effects. Umbelliprenin inhibits lipoxygenase managing the inflammation pathways. In inflammatory macrophages, Umbelliprenin suppresses nitric oxide production as well as inducible nitric oxide synthase (NO synthase) [1]. Uses: Scientific research. Group: Natural products. CAS No. 23838-17-7. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-127029A. | |
| Umbellulone | Offensive principle of the so-called "headache tree". Causes a painful cold sensation. Selective TRPA1 activator. Weak TRPM8 activator. Releases CGRP (calcitoningene-related peptide) after TRPA1 activation which leads to activation of trigeminovascular pathways and CGRP-mediated neurogenic vasodilatation relevant to produce headache/migraine. Group: Biochemicals. Grades: Highly Purified. CAS No. 546-78-1. Pack Sizes: 10mg. Molecular Formula: C10H14O. US Biological Life Sciences. | Worldwide |
| Umber | Heterocyclic Organic Compound. CAS No. 12713-03-0. Catalog: ACM12713030. | |
| Umbilical Vein Endothelial Cells, Human (Frozen) | Passage 1 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >20 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: 1ml. US Biological Life Sciences. | Worldwide |
| Umbilical Vein Endothelial Cells, Human (T-25 flask) | Passage 1 cells are shipped in proliferating culture with a confluence of >90%. ENDO-Growth medium containing 5% serum and growth supplement is recommended for culture. Cells have an average population doubling level of >20 when cultured. Group: Biologicals. Grades: Cell Culture Grade. Pack Sizes: T-25 flask. US Biological Life Sciences. | Worldwide |
| Umbilicaric acid | Umbilicaric acid is an organic polyphenolic carboxylic acid. CAS No. 30666-92-3. Molecular formula: C25H22O10. Mole weight: 482.44. | |
| Umbralisib | Umbralisib is an orally bioavailable and selective PI3K delta inhibitor that targets delta isoform with nanomolar potency, which is approximately 1000-fold selective over alpha isoform, >30-50 fold over beta isoform and >15-50 fold over gamma isoforms. Umbralisib is developed for lymphoma therapy. Synonyms: TGR-1202; TGR 1202; TGR1202; RP5264; 2-[(1S)-1-[4-amino-3-(3-fluoro-4-propan-2-yloxyphenyl)pyrazolo[3,4-d]pyrimidin-1-yl]ethyl]-6-fluoro-3-(3-fluorophenyl)chromen-4-one. CAS No. 1532533-67-7. Molecular formula: C31H24F3N5O3. Mole weight: 571.5. | |
| Umbralisib | Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202; RP5264. CAS No. 1532533-67-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279. | |
| Umbralisib hydrochloride | Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε ( CK1ε ) inhibitor, with EC 50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] [2] [3] [4]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: TGR-1202 hydrochloride; RP5264 hydrochloride. CAS No. 1532533-78-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12279C. | |
| Umeclidinium bromide | Umeclidinium bromide is a novel mAChR antagonist. The affinity ( K i ) of Umeclidinium bromide for the cloned human M1-M5 mAChRs ranges from 0.05 to 0.16 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GSK573719A. CAS No. 869113-09-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12100. | |
| Umeclidinium bromide | Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD). Synonyms: GSK-573719, GSK573719, GSK 573719, GSK-573719A, GSK573719A, GSK 573719A, Incruse Ellipta, Umeclidinium bromide. Grades: 0.99. CAS No. 869113-09-7. Molecular formula: C29H34BrNO2. Mole weight: 508.5. | |
| UMI-77 | UMI-77 is a selective Mcl-1 inhibitor with Ki of 490 nM, showing selectivity over other members of Bcl-2 family. Synonyms: UMI-77, UMI77, UMI 77. Grades: >98%. CAS No. 518303-20-3. Molecular formula: C18H14BrNO5S2. Mole weight: 468.34. | |
| Umibecestat free base | Umibecestat, also known as CNP-520, is a beta-secretase inhibitor and is a drug candidate for prevention trials in Alzheimer's disease. CNP520 has a selectivity, pharmacodynamics, and distribution profile suitable for AD prevention studies. CNP520 reduced brain and cerebrospinal fluid (CSF) Aβ in rats and dogs, and Aβ plaque deposition in APP-transgenic mice. CNP520 reduces Aβ load and neuroinflammation in APP-transgenic mice. Group: Inhibitors. Alternative Names: Umibecestat; CNP-520; CNP 520; CNP520. CAS No. 1387560-01-1. Molecular formula: C19H15ClF7N5O2. Mole weight: 513.8. Appearance: Solid powder. Purity: >98%. IUPACName: N-{6-[(3R,6R)-5-amino-3,6-dimethyl-6-(trifluoromethyl)-3,6-dihydro-2H-1,4-oxazin-3-yl]-5-fluoropyridin-2-yl}-3-chloro-5- (trifluoromethyl)pyridine-2-carboxamide. Canonical SMILES: O=C (C1=NC=C (C (F) (F)F)C=C1Cl)NC2=NC ([C@]3 (C)CO[C@] (C (F) (F)F) (C)C (N)=N3)=C (F)C=C2. Catalog: ACM1387560011. | |
| Umifenovir | Umifenovir is a potent, orally active broad-spectrum antiviral agent with activity against a number of enveloped and non-enveloped viruses. Umifenovir is used as an anti-influenza virus agent. Umifenovir could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir is an efficient inhibitor of SARS-CoV-2 in vitro [2]. Umifenovir shows anti-inflammatory activity [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 131707-25-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-14904. | |
| Umifenovir | Arbidol is an antiviral agent using for the treatment of influenza infection in Russia and China. It inhibits membrane fusion and prevents contact between the virus and target host cells. Fusion between the viral capsid and the cell membrane of the target cell is inhibited and this prevents viral entry to the target cell. Although some Russian studies have shown it to be effective, it is not approved for use in Western countries. Synonyms: Arbidol; 6-Bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic Acid Ethyl Ester. Grades: ≥95%. CAS No. 131707-25-0. Molecular formula: C22H25BrN2O3S. Mole weight: 477.41. | |
| Umifenovir Glucuronide | Umifenovir Glucuronide is an impurity of Arbidol, which is an antiviral agent used for the treatment of influenza infection. Synonyms: 6-Bromo-4-[(dimethylamino)methyl]-3-(ethoxycarbonyl)-1-methyl-2-[(phenylthio)methyl]-1H-indol-5-yl β-D-glucopyranosiduronic Acid; Arbidol O-Glucuronide; 6-Bromo-4-[(dimethylamino)methyl]-3-(ethoxycarbonyl)-1-methyl-2-[(phenylsulfanyl)methyl]-1H-indol-5-yl β-D-glucopyranosiduronic acid; 1H-Indole-3-carboxylic acid, 6-bromo-4-[(dimethylamino)methyl]-5-(β-D-glucopyranuronosyloxy)-1-methyl-2-[(phenylthio)methyl]-, ethyl ester. Grades: >98%. CAS No. 1130900-96-7. Molecular formula: C28H33BrN2O9S. Mole weight: 653.54. | |
| Umifenovir hydrochloride | Umifenovir hydrochloride is a potent, orally active broad-spectrum antiviral with activity against a number of enveloped and non-enveloped viruses. Umifenovir hydrochloride is used as an anti-influenza virus agent. Umifenovir hydrochloride could effectively inhibit the fusion of virus with host cells [1] [2]. Umifenovir hydrochloride is an efficient inhibitor of SARS-CoV-2 in vitro. Anti-inflammatory activity [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 131707-23-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-14904A. | |
| Umifenovir Sulfate | Umifenovir Sulfate is an impurity of Arbidol, which is an antiviral agent used for the treatment of influenza infection. Synonyms: Ethyl 6-bromo-4-[(dimethylamino)methyl]-1-methyl-2-[(phenylsulfanyl)methyl]-5-(sulfooxy)-1H-indole-3-carboxylate; 1H-Indole-3-carboxylic acid, 6-bromo-4-[(dimethylamino)methyl]-1-methyl-2-[(phenylthio)methyl]-5-(sulfooxy)-, 3-ethyl ester; 3-Ethyl Ester 6-Bromo-4-[(dimethylamino)methyl]-1-methyl-2-[(phenylthio)methyl]-5-(sulfooxy)-1H-indole-3-carboxylic Acid; Arbidol Sulfate. Grades: >98%. CAS No. 1443454-70-3. Molecular formula: C22H25BrN2O6S2. Mole weight: 557.48. | |
| Umirolimus | Umirolimus, a macrocyclic triene lactone Rapamycin derivative, is powerful immunosuppressant and anti-inflammatory agent. Umirolimus has highly lipophilicity and can be used agent-eluting stent (DES) applications [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 851536-75-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-122402. | |
| Umirolimus | A semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group. It is one of the most hydrophobic tacrolimus analogues. It binds to the cytosolic FK-binding protein 12 (FKBP12) to inhibit the mammalian target of rapamycin (mTOR) pathway. Synonyms: Biolimus; Biolimus A9; TRM 986; 42-O-(2-Ethoxyethyl)rapamycin. Grades: >95% by HPLC. CAS No. 851536-75-9. Molecular formula: C55H87NO14. Mole weight: 986.28. | |
| UMP/CMP kinase | This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. Group: Enzymes. Synonyms: cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Enzyme Commission Number: EC 2.7.4.14. CAS No. 37278-21-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3195; UMP/CMP kinase; EC 2.7.4.14; 37278-21-0; cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Cat No: EXWM-3195. |  |
| UMP-CP | UMP-CP is a non-hydrolytic analogue of UDP and a starting structure in the synthesis of α/β hydrolysis-resistant tri- and polyphosphates. Synonyms: Uridine- 5'- O- (α, β- methylene)diphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 732921-73-2. Molecular formula: C10H16N2O11P2 (free acid). Mole weight: 402.2 (free acid). | |
| UMP kinase | This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP. Group: Enzymes. Synonyms: uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA. Enzyme Commission Number: EC 2.7.4.22. CAS No. 9036-23-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3204; UMP kinase; EC 2.7.4.22; 9036-23-1; uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA. Cat No: EXWM-3204. | |
| UN6HA1 60L | 1ea Pack Size. Group: Equipment. Prepack ID 90027219-1ea. See USA prepack pricing. |  |
| UNBS3157 | UNBS3157 is a DNA intercalator, and a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. Amonafide, a naphthalimide which binds to DNA by intercalation and poisons topoisomerase IIalpha, has demonstrated activity in phase II breast cancer trials, but has failed thus far to enter clinical phase III because of dose-limiting bone marrow toxicity. Synonyms: UNBS 3157; UNBS-3157. Grades: 98%. CAS No. 868962-26-9. Molecular formula: C19H17Cl3N4O4. Mole weight: 471.72. | |
| UNBS5162 | UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Synonyms: [2-[2-(dimethylamino)ethyl]-1,3-dioxobenzo[de]isoquinolin-5-yl]urea; UNBS 5162; UNBS-5162; UNBS5162. CAS No. 956590-23-1. Molecular formula: C17H18N4O3. Mole weight: 326.35. | |
| UNBS5162 | UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 956590-23-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16509. | |
| UNC0224 | The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase). Synonyms: UNC0224; UNC-0224; UNC 0224; 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine. Grades: >98%. CAS No. 1197196-48-7. Molecular formula: C26H43N7O2. Mole weight: 485.67. | |
| UNC 0224 | UNC 0224. Group: Biochemicals. Grades: Purified. CAS No. 1197196-48-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC0321 | UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date. Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth, and the dimethylation of p53 K373 results in the inactivation of p53. Synonyms: UNC0321, UNC-0321, UNC 0321, CHEMBL1214066, CHEBI:785916, UNC0321 (trifluoroacetate salt), NCGC0018778901, KB81388. Grades: >98%. CAS No. 1238673-32-9. Molecular formula: C27H45N7O3. Mole weight: 515.69. | |
| UNC0321 (TFA Salt) | UNC0321 (trifluoroacetate salt) is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP (also known as EHMT1), with IC50 of 6nM and 15nM, respectively. It is more than 40,000-fold more selective for G9a and GLP vs. SET7/9, SET8, PRMT3, or JMJD2E. Group: Biochemicals. Alternative Names: 4-Quinazolinamine, 7-[2-[2- (dimethylamino) ethoxy]ethoxy]-2- (hexahydro-4-methyl-1H-1, 4-diazepin-1-yl) -6-methoxy-N- (1-methyl-4-piperidinyl) -, trifluoroacetate. Grades: Highly Purified. CAS No. 1238673-32-9 (free base). Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 ( KMT5A ) with an IC 50 of 7.3 μM, K D value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620401-82-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12335. | |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. Synonyms: UNC0379, UNC-0379, UNC 0379. Grades: 0.98. CAS No. 1620401-82-2. Molecular formula: C23H35N5O2. Mole weight: 413.566. | |
| UNC0379 trifluoroacetate | UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. Synonyms: UNC-0379 trifluoroacetate; UNC 0379 trifluoroacetate; UNC0379 trifluoroacetate. Grades: >98%. CAS No. 1620401-83-3. Molecular formula: C25H36F3N5O4. Mole weight: 527.58. | |
| UNC-0631 | UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM. Synonyms: UNC0631, UNC 0631, UNC-0631. CAS No. 1320288-19-4. Molecular formula: C37H61N7O2. Mole weight: 635.942. | |
| UNC0638 | UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC 50 of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin ( HbF ) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti- FMDV (foot-and-mouth disease virus) and anti- VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255580-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15273. | |
| UNC-0638 | UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. UNC0638 markedly reduced the clonogenicity of MCF7 cells, reduced the abundance of H3K9me2 marks at promoters of known G9a-regulated endogenous genes and disproportionately affected several genomic loci encoding microRNAs. Synonyms: UNC0638, UNC-0638, UNC 0638. Grades: 0.98. CAS No. 1255580-76-7. Molecular formula: C30H47N5O2. Mole weight: 509.739. | |
| UNC0638 hydrate | UNC 0638 is a selective inhibitor of G9a/EHMT2 and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and> 10000 nM for a panel of other histone methyltransferases). UNC 0638 inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Synonyms: UNC 0638; UNC0638; UNC-0638; 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine. Grades: ≥99% by HPLC. CAS No. 1255517-77-1. Molecular formula: C30H49N5O3. Mole weight: 527.7. | |
| UNC0642 | UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. Synonyms: UNC0642; UNC-0642; UNC 0642. Grades: 98%. CAS No. 1481677-78-4. Molecular formula: C29H44F2N6O2. Mole weight: 546.71. | |
| UNC0646 | UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. Synonyms: UNC0646, UNC 0646, UNC-0646. Grades: 0.98. CAS No. 1320288-17-2. Molecular formula: C36H59N7O2. Mole weight: 621.915. | |
| UNC 0646 | UNC 0646. Group: Biochemicals. Grades: Purified. CAS No. 1320288-17-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC1215 | UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. Synonyms: UNC1215, UNC-1215, UNC 1215; (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone). Grades: >98%. CAS No. 1415800-43-9. Molecular formula: C32H43N5O2. Mole weight: 529.729. | |
| UNC 1215 | UNC 1215. Group: Biochemicals. Alternative Names: 2-Phenylamino-1, 4-[4- (pyrrolidinyl) piperidinyl) benzamide. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C32H43N5O2, Molecular Weight: 529.72. US Biological Life Sciences. | Worldwide |
| UNC1999 | UNC1999. Group: Biochemicals. Alternative Names: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-Indazole-4-carboxamide. Grades: Highly Purified. CAS No. 1431612-23-5. Pack Sizes: 5mg. Molecular Formula: C33H43N7O2, Molecular Weight: 569.74. US Biological Life Sciences. | Worldwide |
| UNC-1999 | UNC1999, the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1. UNC1999 was highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets. UNC1999 was orally bioavailable in mice, making this inhibitor a valuable tool for investigating the role of EZH2 and EZH1 in chronic animal studies. UNC-1999 represents a useful tools for the biomedical community to investigate the role of EZH2 and EZH1 in health and disease. Synonyms: UNC1999; UNC 1999; UNC-1999. Grades: 0.98. CAS No. 1431612-23-5. Molecular formula: C33H43N7O2. Mole weight: 569.754. | |
| UNC-2025 | UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. Synonyms: Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-; trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol; MRX 6313; UNC 2025; UNC2025. Grades: ≥95%. CAS No. 1429881-91-3. Molecular formula: C28H40N6O. Mole weight: 476.66. | |
| UNC-2025 hydrochloride | UNC-2025 hydrochloride is the hydrochloride salt of UNC-2025, which is the Mer/FLT3 dual inhibitor. Synonyms: UNC-2025 hydrochloride; UNC 2025 hydrochloride; UNC2025 hydrochloride; (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol hydrochloride. Grades: >98%. CAS No. 2070015-17-5. Molecular formula: C28H41ClN6O. Mole weight: 513.12. | |
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