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UNC-2170 is a functionally active, fragment-like ligand for 53BP1 ( IC 50 =29 μM; K d =22 μM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648707-58-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115531.
UNC2170 maleate
UNC2170 is a p53-Binding protein 1 (53BP1) antagonist that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer. Synonyms: 3-bromo-N-[3-(tert-butylamino)propyl]benzamide maleate. Grades: ≥95%. Molecular formula: C14H21BrN2O·C4H4O4. Mole weight: 429.3.
UNC2250
UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer. Synonyms: UNC-2250; UNC 2250. Grades: 98%. CAS No. 1493694-70-4. Molecular formula: C24H36N6O2. Mole weight: 440.58.
UNC 2327
UNC 2327. Group: Biochemicals. Grades: Purified. CAS No. 1426152-53-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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UNC 2327
UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Synonyms: UNC2327; UNC-2327; UNC 2327; N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea. Grades: ≥99% by HPLC. CAS No. 1426152-53-5. Molecular formula: C14H17N5O2S. Mole weight: 319.38.
UNC 2399
UNC 2400
UNC 2400 is a negative control of UNC 1999 that displays 1000-fold lower potency than active analog (IC50 = 62 and >200 μM for EZH1 and EZH2, respectively). Synonyms: UNC2400; UNC-2400; UNC 2400; N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 1433200-49-7. Molecular formula: C35H47N7O2. Mole weight: 597.79.
UNC2541
UNC2541 is a potent specific inhibitor of Mer tyrosine kinase (MerTK). Synonyms: UNC-2541; UNC 2541. Grades: ≥98% by HPLC. CAS No. 1612782-86-1. Molecular formula: C24H34FN7O2. Mole weight: 471.6.
UNC2881
UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis. Synonyms: UNC2881; UNC 2881; UNC-2881. Grades: 98%. CAS No. 1493764-08-1. Molecular formula: C25H33N7O2. Mole weight: 463.586.
UNC 3230
UNC 3230. Group: Biochemicals. Grades: Purified. CAS No. 1031602-63-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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UNC 3230
UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM), displaying selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. UNC 3230 decreases PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. UNC 3230 exhibits antinociceptive effects in mouse models of chronic pain. Synonyms: UNC3230; UNC-3230; UNC 3230; 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide. Grades: ≥99% by HPLC. CAS No. 1031602-63-7. Molecular formula: C17H20N4O2S. Mole weight: 344.43.
UNC 3866
UNC 3866 is a potent and high affinity CBX4 and CBX7 inhibitor (Ki = 94 and 97 nM, respectively) displaying > 6-fold selectivity over other CBX and CDY family members. UNC 3866 was shown to inhibit the proliferation of PC3 cells in vitro. Synonyms: UNC3866, UNC-3866, UNC 3866; N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester. CAS No. 1872382-47-2. Molecular formula: C43H66N6O8. Mole weight: 795.02.
UNC569
Mer proto-oncogene tyrosine kinase (MerTK) is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). UNC569 is a specific MerTK inhibitor. Synonyms: 1-[(Trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine. Grades: 98%. CAS No. 1350547-65-7. Molecular formula: C22H29FN6. Mole weight: 396.50.
UNC 669
(5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT). Synonyms: UNC669; UNC-669. Grades: >98%. CAS No. 1314241-44-5. Molecular formula: C15H20BrN3O. Mole weight: 338.24.
UNC6852
UNC6852 is a selective polycomb inhibitory complex 2 (PRC2) degradation agent based on PROTAC. Synonyms: UNC-6852; UNC 6852; (2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 2688842-08-0. Molecular formula: C43H48N10O6S. Mole weight: 832.99.
UNC6934
UNC6934 is a novel potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 ± 18 nM, being selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1, the closest on the phylogenetic tree, disrupting the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells. Group: Antagonists. Alternative Names: UNC6934; UNC-6934; UNC 6934. CAS No. 2561494-77-5. Molecular formula: C24H21N5O4. Mole weight: 443.46. Appearance: Solid powder. Purity: >98%. IUPACName: N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide. Canonical SMILES: O=C (C1=CC=C (N2)C (OCC2=O)=C1)N (C3CC3)CC4=CC=C (C (NC5=NC=NC=C5)=O)C=C4. Catalog: ACM2561494775.
UNC6934
UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization. Uses: Scientific research. Group: Signaling pathways. CAS No. 2561494-77-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145103.
UNC8153 TFA
UNC8153 TFA is a potent and selective nuclear receptor-binding SET domain-containing 2 (NSD2) -targeted degrader with a K d of 24 nM. UNC8153 TFA reduces the cellular levels of both NSD2 protein and the H3K36me2 chromatin mark. UNC8153 TFA contains a simple warhead that confers proteasome-dependent degradation of NSD2 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2929304-61-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg. Product ID: HY-157251.
UNC-926
UNC-926 is a methyl-lysine (Kme) reader domain inhibitor which binds to the MBT domain of L3MVTL protein (IC50 = 3.9 μM). Synonyms: UNC-926; UNC 926; UNC926; (3-bromophenyl)-(4-pyrrolidin-1-ylpiperidin-1-yl)methanone. CAS No. 1184136-10-4. Molecular formula: C16H21BrN2O. Mole weight: 337.25.
UNC 926 hydrochloride
UNC 926 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 1184136-10-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
UNC 9994 hydrochloride
UNC 9994 hydrochloride is a β-arrestin-biased functionally selective dopamine D2 receptor (D2R) agonist (Ki value 30 nM; EC50 value 50 nM in β-arrestin-2 recruitment assay) with antipsychotic activity in vivo. Synonyms: UNC 9994 hydrochloride; UNC9994 hydrochloride; UNC-9994 hydrochloride; 5-[3-[4-(2,3-dichlorophenyl)piperidin-1-yl]propoxy]-1,3-benzothiazole hydrochloride. Grades: 99%. CAS No. 2108826-33-9. Molecular formula: C21H22Cl2N2OS.HCl. Mole weight: 457.84.
Botanical Source: Group: Biochemicals. Alternative Names: Isospeciophylline, Pteropodine. Grades: Plant Grade. CAS No. 5629-60-7. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Uncharacterized protein C18orf8 (501-509)
Uncharacterized protein C18orf8 (501-509) is a 9-aa peptide. It is a componement of the CCZ1-MON1 RAB7A guanine exchange factor (GEF). This peptide can be used in Ovarian carcinoma research. Synonyms: Colon cancer-associated protein Mic1 (501-509).
Unconventional myosin-Ib (911-919)
A peptide fragment of Unconventional myosin-Ib. Unconventional myosin-Ib is a motor protein that may participate in process critical to neuronal development and function such as cell migration, neurite outgrowth and vesicular transport. Synonyms: MYH-1c (911-919); Myosin I alpha (911-919).
Undecane has anti-allergic and anti-inflammatory activities on sensitized rat basophilic leukemia (RBL-2H3) mast cells and HaCaT keratinocytes. In sensitized mast cells, Undecane inhibits degranulation and the secretion of histamine and TNF-α [. Uses: Scientific research. Group: Natural products. CAS No. 1120-21-4. Pack Sizes: 10 mM * 1 mL; 10 g; 25 g. Product ID: HY-N8593.
Undecane -1, 11-diyl-bismethane thiosulfonate
Undecane -1, 11-diyl-bismethane thiosulfonate. Group: Biochemicals. Alternative Names: MTS-11-MTS. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C13H28O4S4, Molecular Weight: 376.62. US Biological Life Sciences.
Worldwide
Undecane-1,2-diol
Heterocyclic Organic Compound. Alternative Names: undecane-1,2-diol;1,2-Undecanediol;Ai3-13218;Einecs 235-848-2. CAS No. 13006-29-6. Molecular formula: C11H24O2. Mole weight: 188.30706. Catalog: ACM13006296.
Undecanedioic acid is associated with intercellular matrix macromolecules and specifically with elastin. Uses: Scientific research. Group: Natural products. CAS No. 1852-04-6. Pack Sizes: 10 mM * 1 mL; 100 mg; 1 g. Product ID: HY-W014125.
Undecanedioic Acid
OtherSolid;Solid. Uses: This product is suitable for scientific research. Group: Monomers. Alternative Names: Undecane-1,11-dioic acid. CAS No. 1852-04-6. Product ID: Undecanedioic acid. Molecular formula: 216.27. Mole weight: C11H20O4. C(CCCCC(=O)O)CCCCC(=O)O. InChI=1S/C11H20O4/c12-10 (13)8-6-4-2-1-3-5-7-9-11 (14)15/h1-9H2, (H, 12, 13) (H, 14, 15). LWBHHRRTOZQPDM-UHFFFAOYSA-N. 97%.
Undecanedioic Acid
OtherSolid;Solid. Uses: This product is suitable for scientific research. Group: Polymer/macromolecule. Alternative Names: Undecane-1,11-dioic acid. CAS No. 1852-04-6. Molecular formula: C11H20O4. Mole weight: 216.27. Appearance: White to off-white solid. Purity: 0.97. IUPACName: Undecanedioic acid. Canonical SMILES: C(CCCCC(=O)O)CCCCC(=O)O. Density: 1.16 g/ml. ECNumber: 217-440-6. Catalog: ACM1852046-1.
Undecanoic acid (Undecanoate) is a monocarboxylic acid with antimycotic property, which inhibits the production of exocellular keratinase, lipase and the biosynthesis of several phospholipids in T. rubrum [1]. Uses: Scientific research. Group: Natural products. Alternative Names: Undecanoate; Hendecanoic acid. CAS No. 112-37-8. Pack Sizes: 10 mM * 1 mL; 1 g; 5 g. Product ID: HY-W004282.
Undecanoic acid
Undecanoic acid. Group: Biochemicals. Grades: Highly Purified. CAS No. 112-37-8. Pack Sizes: 1kg, 2kg, 5kg, 10kg, 25kg. Molecular Formula: C11H22O2. US Biological Life Sciences.
Worldwide
Undecanoic Acid
Undecanoic acid is a white crystalline solid. Insoluble in water. Specific gravity 0.85. Hence floats on water.;Solid;Solid;colourless crystals/ faint fatty, aldehydic odour. Group: Inhibitors. Alternative Names: Hendecanoic Acid. CAS No. 112-37-8. Molecular formula: C11H22O2. Mole weight: 186.29. Appearance: Colourless to light yellow liquid or solid. Purity: 0.99. IUPACName: undecanoic acid. Canonical SMILES: CCCCCCCCCCC(=O)O. Density: 0.909 g/cm³. ECNumber: 203-964-2. Catalog: ACM112378.
Undecanoic Acid
Undecanoic acid is a white crystalline solid. Insoluble in water. Specific gravity 0.85. Hence floats on water.;Solid;Solid;colourless crystals/ faint fatty, aldehydic odour. Group: Solubility enhancing reagents. Alternative Names: Hendecanoic Acid. CAS No. 112-37-8. Pack Sizes: 100 g. Product ID: undecanoic acid. Molecular formula: 186.29. Mole weight: C11H22O2. CCCCCCCCCCC(=O)O. InChI=1S / C11H22O2 / c1-2-3-4-5-6-7-8-9-10-11 (12) 13 / h2-10H2, 1H3, (H, 12, 13). ZDPHROOEEOARMN-UHFFFAOYSA-N. 99%.
Undecanoyl-N-hydroxyethylglucamide is an extraordinary biomedical compound showcasing remarkable attributes encompassing emulsifying, foaming and cleansing capabilities. It can seamlessly integrate into cosmetic and pharmaceutical compositions. Synonyms: HEGA-11. CAS No. 869654-10-4. Molecular formula: C19H39NO7. Mole weight: 393.52.
undecaprenol kinase
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. This enzyme participates in peptidoglycan biosynthesis. Group: Enzymes. Synonyms: isoprenoid alcohol kinase; isoprenoid alcohol phosphokinase; C55-isoprenoid alcohol phosphokinase; isoprenoid alcohol kinase (phosphorylating); C55-isoprenoid alcohol kinase; C55-isoprenyl alcohol phosphokinase; polyisoprenol kinase. Enzyme Commission Number: EC 2.7.1.66. CAS No. 9068-22-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3097; undecaprenol kinase; EC 2.7.1.66; 9068-22-8; isoprenoid alcohol kinase; isoprenoid alcohol phosphokinase; C55-isoprenoid alcohol phosphokinase; isoprenoid alcohol kinase (phosphorylating); C55-isoprenoid alcohol kinase; C55-isoprenyl alcohol phosphokinase; polyisoprenol kinase. Cat No: EXWM-3097.
undecaprenyl-diphosphate phosphatase
Isolated from the bacteria Micrococcus lysodeikticus, Escherichia coli and Bacillus subtilis. The product of the reaction, ditrans,octacis-undecaprenyl phosphate, is essential for cell wall polysaccharide biosynthesis in these strains. Group: Enzymes. Synonyms: C55-isoprenyl diphosphatase; C55-isoprenyl pyrophosphatase; isoprenyl pyrophosphatase (ambiguous); undecaprenyl pyrophosphate phosphatase; undecaprenyl pyrophosphate pyrophosphatase; UPP phosphatase; Und-PP pyrophosphatase; UppP (ambiguous); BacA; undecaprenyl-diphosphate phosphohydrolase; undecaprenyl-diphosphatase. Enzyme Commission Number: EC 3.6.1.27. CAS No. 9077-80-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4611; undecaprenyl-diphosphate phosphatase; EC 3.6.1.27; 9077-80-9; C55-isoprenyl diphosphatase; C55-isoprenyl pyrophosphatase; isoprenyl pyrophosphatase (ambiguous); undecaprenyl pyrophosphate phosphatase; undecaprenyl pyrophosphate pyrophosphatase; UPP phosphatase; Und-PP pyrophosphatase; UppP (ambiguous); BacA; undecaprenyl-diphosphate phosphohydrolase; undecaprenyl-diphosphatase. Cat No: EXWM-4611.
The enzyme also works when the lysine residue is replaced by meso-2,6-diaminoheptanedioate (meso-2,6-diaminopimelate, A2pm) combined with adjacent residues through its L-centre, as it is in Gram-negative and some Gram-positive organisms. The undecaprenol involved is ditrans,octacis-undecaprenol (for definitions, click here). Group: Enzymes. Synonyms: MurG transferase; UDP-N-acetyl-D-glucosamine:N-acetyl-α-D-muramyl(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol β-1,4-N-acetylglucosaminlytransferase. Enzyme Commission Number: EC 2.4.1.227. CAS No. 60976-26-3. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2456; undecaprenyldiphospho-muramoylpentapeptide β-N-acetylglucosaminyltransferase; EC 2.4.1.227; 60976-26-3; MurG transferase; UDP-N-acetyl-D-glucosamine:N-acetyl-α-D-muramyl(oyl-L-Ala-γ-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol β-1,4-N-acetylglucosaminlytransferase. Cat No: EXWM-2456.
A bacterial enzyme that has been isolated from Campylobacter jejuni and Campylobacter lari. It forms a glycoprotein by the transfer of a glucosyl-N-acetylgalactosaminyl-N,N'-diacetylbacillosamine (GalNAc2(Glc)GalNAc3diNAcBac) polysaccharide and related oligosaccharides to the side-chain of an L-asparagine residue in the sequence -Asp/Glu-Xaa-Asn-Xaa'-Ser/Thr- (Xaa and Xaa' not Pro) in nascent polypeptide chains. Requires Mn2+ or Mg2+. Occurs on the external face of the plasma membrane. The polyprenol involved is normally tritrans,heptacis-undecaprenol but a decaprenol is used by some species. Group: Enzymes. Synonyms: PglB. Enzyme Commission Number: EC 2.4.99.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-2703; undecaprenyl-diphosphooligosaccharide-protein glycotransferase; EC 2.4.99.19; PglB. Cat No: EXWM-2703.