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| Product | Description | |
|---|---|---|
| UMP/CMP kinase | This eukaryotic enzyme is a bifunctional enzyme that catalyses the phosphorylation of both CMP and UMP with similar efficiency. dCMP can also act as acceptor. Different from the monofunctional prokaryotic enzymes EC 2.7.4.25, CMP kinase and EC 2.7.4.22, UMP kinase. Group: Enzymes. Synonyms: cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Enzyme Commission Number: EC 2.7.4.14. CAS No. 37278-21-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3195; UMP/CMP kinase; EC 2.7.4.14; 37278-21-0; cytidylate kinase; deoxycytidylate kinase; CTP:CMP phosphotransferase; dCMP kinase; deoxycytidine monophosphokinase; UMP-CMP kinase; ATP:UMP-CMP phosphotransferase; pyrimidine nucleoside monophosphate kinase; uridine monophosphate-cytidine monophosphate phosphotransferase. Cat No: EXWM-3195. |  |
| UMP-CP | UMP-CP is a non-hydrolytic analogue of UDP and a starting structure in the synthesis of α/β hydrolysis-resistant tri- and polyphosphates. Synonyms: Uridine- 5'- O- (α, β- methylene)diphosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 732921-73-2. Molecular formula: C10H16N2O11P2 (free acid). Mole weight: 402.2 (free acid). |  |
| UMP kinase | This enzyme is strictly specific for UMP as substrate and is used by prokaryotes in the de novo synthesis of pyrimidines, in contrast to eukaryotes, which use the dual-specificity enzyme UMP/CMP kinase (EC 2.7.4.14) for the same purpose. This enzyme is the subject of feedback regulation, being inhibited by UTP and activated by GTP. Group: Enzymes. Synonyms: uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA. Enzyme Commission Number: EC 2.7.4.22. CAS No. 9036-23-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3204; UMP kinase; EC 2.7.4.22; 9036-23-1; uridylate kinase; UMPK; uridine monophosphate kinase; PyrH; UMP-kinase; SmbA. Cat No: EXWM-3204. | |
| UN6HA1 60L | 1ea Pack Size. Group: Equipment. Prepack ID 90027219-1ea. See USA prepack pricing. |  |
| UNBS3157 | UNBS3157 is a DNA intercalator, and a novel nonhematotoxic naphthalimide derivative with potent antitumor activity. Amonafide, a naphthalimide which binds to DNA by intercalation and poisons topoisomerase IIalpha, has demonstrated activity in phase II breast cancer trials, but has failed thus far to enter clinical phase III because of dose-limiting bone marrow toxicity. Synonyms: UNBS 3157; UNBS-3157. Grades: 98%. CAS No. 868962-26-9. Molecular formula: C19H17Cl3N4O4. Mole weight: 471.72. | |
| UNBS5162 | UNBS5162 is a pan-antagonist of CXCL chemokine expression, with anti-tumor activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 956590-23-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-16509. |  |
| UNBS5162 | UNBS5162 is a novel naphthalimide that decreases CXCL chemokine expression in experimental prostate cancers. Synonyms: [2-[2-(dimethylamino)ethyl]-1,3-dioxobenzo[de]isoquinolin-5-yl]urea; UNBS 5162; UNBS-5162; UNBS5162. CAS No. 956590-23-1. Molecular formula: C17H18N4O3. Mole weight: 326.35. | |
| UNC0224 | UNC0224 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 2.6 nM, an IC50 of 15 nM and a Kd of 23 nM. UNC0224 also potently inhibits b>GLP with assay-dependent IC50 values of 20-58 nM. UNC0224 is inactive against SET7/9, SET8/PreSET7, PRMT3 and JMJD2E[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1197196-48-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-10929. | |
| UNC0224 | The methylation of lysine residues on histones plays a central role in determining euchromatin structure and gene expression. The histone methyltransferase (HMTase) G9a can mono- or dimethylate lysine 9 on histone 3 (H3), contributing to early embryogenesis, genomic imprinting, and lymphocyte development. UNC0224 is a potent and selective G9a HMTase inhibitor, exhibiting an IC50 value of 15 nM. Isothermal titration calorimetry revealed UNC0224 binds to G9a with a Kd value of 29 nM. UNC0224 also inhibits GLP, a closely-related H3K9 HMTase, with assay-dependent IC50 values of 20-58 nM, but is more than 1,000-fold selective against SET7/9 (a H3K4 HMTase) and SET8 (a H4K20 HMTase). Synonyms: UNC0224; UNC-0224; UNC 0224; 7-[3-(Dimethylamino)propoxy]-2-(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6-methoxy-N-(1-methyl-4-piperidinyl)-4-quinazolinamine. Grades: >98%. CAS No. 1197196-48-7. Molecular formula: C26H43N7O2. Mole weight: 485.67. | |
| UNC 0224 | UNC 0224. Group: Biochemicals. Grades: Purified. CAS No. 1197196-48-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| UNC0321 | UNC0321 is a potent and selective histone methyltransferase G9a inhibitor with a Ki of 63 pM and with assay-dependent IC50 values of 6-9 nM. UNC0321 also inhibits GLP with assay-dependent IC50 values of 15-23 nM. UNC0321 has anti-apoptotic activity and has potential application in diabetic vascular complications[1][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1238673-32-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-10930. | |
| UNC0321 | UNC0321 is the first G9a inhibitor with picomolar potency and the most potent G9a inhibitor to date. Protein lysine methyltransferase G9a, which catalyzes methylation of lysine 9 of histone H3 (H3K9) and lysine 373 (K373) of p53, is overexpressed in human cancers. Genetic knockdown of G9a inhibits cancer cell growth, and the dimethylation of p53 K373 results in the inactivation of p53. Synonyms: UNC0321, UNC-0321, UNC 0321, CHEMBL1214066, CHEBI:785916, UNC0321 (trifluoroacetate salt), NCGC0018778901, KB81388. Grades: >98%. CAS No. 1238673-32-9. Molecular formula: C27H45N7O3. Mole weight: 515.69. | |
| UNC0321 (TFA Salt) | UNC0321 (trifluoroacetate salt) is a selective histone lysine methyltransferase (HMTase) inhibitor for G9a and GLP (also known as EHMT1), with IC50 of 6nM and 15nM, respectively. It is more than 40,000-fold more selective for G9a and GLP vs. SET7/9, SET8, PRMT3, or JMJD2E. Group: Biochemicals. Alternative Names: 4-Quinazolinamine, 7-[2-[2- (dimethylamino) ethoxy]ethoxy]-2- (hexahydro-4-methyl-1H-1, 4-diazepin-1-yl) -6-methoxy-N- (1-methyl-4-piperidinyl) -, trifluoroacetate. Grades: Highly Purified. CAS No. 1238673-32-9 (free base). Pack Sizes: 50mg. US Biological Life Sciences. | Worldwide |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8. UNC0379 is active in multiple biochemical assays. Its affinity to SETD8 was confirmed by ITC (isothermal titration calorimetry) and SPR (surface plasmon resonance) studies. Importantly, UNC0379 is selective for SETD8 over 15 other methyltransferases. Synonyms: UNC0379, UNC-0379, UNC 0379. Grades: 0.98. CAS No. 1620401-82-2. Molecular formula: C23H35N5O2. Mole weight: 413.566. | |
| UNC0379 | UNC0379 is a selective, substrate-competitive inhibitor of lysine methyltransferase SETD8 ( KMT5A ) with an IC 50 of 7.3 μM, K D value of 18.3 μM. UNC0379 can be used in the research of inflammation and cancers, such as pulmonary fibrosis, ovarian cancer, neuroblastoma [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1620401-82-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-12335. | |
| UNC0379 trifluoroacetate | UNC0379 trifluoroacetate is a selective, substrate-competitive inhibitor of the lysine methyltransferase SETD8 with IC50 of 7.3±1.0 uM; selective over 15 other methyltransferases. Synonyms: UNC-0379 trifluoroacetate; UNC 0379 trifluoroacetate; UNC0379 trifluoroacetate. Grades: >98%. CAS No. 1620401-83-3. Molecular formula: C25H36F3N5O4. Mole weight: 527.58. | |
| UNC0379 trifluoroacetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. |  |
| UNC 0631 | UNC 0631 is a potent histone methyltransferase G9a inhibitor with an IC50 of 4 nM. UNC 0631 potently reduces H3K9me2 levels in MDA-MB-231 cells with an IC50 of 25 nM[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1320288-19-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-13808. | |
| UNC-0631 | UNC 0631 is a potent G9a inhibitor with IC50 value of 4 nM. Synonyms: UNC0631, UNC 0631, UNC-0631. CAS No. 1320288-19-4. Molecular formula: C37H61N7O2. Mole weight: 635.942. | |
| UNC0638 | UNC0638 selectively inhibits G9a and GLP histone methyltransferases with IC 50 of 15 nM and 19 nM, respectively. UNC0638 inhibits TNBC cell invasion and migration in vitro. UNC0638 is also an inhibitor of EHMT1/2 and induces fetal hemoglobin ( HbF ) expression in human erythroid progenitor cell culture. In addition, UNC0638 has anti- FMDV (foot-and-mouth disease virus) and anti- VSV (vesicular stomatitis virus) activities, with excellent potency and selectivity against multiple epigenetic and non-epigenetic targets [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1255580-76-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15273. | |
| UNC-0638 | UNC0638 is an inhibitor of G9a and GLP with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets. UNC0638 treatment of a variety of cell lines resulted in lower global H3K9me2 levels, equivalent to levels observed for small hairpin RNA knockdown of G9a and GLP with the functional potency of UNC0638 being well separated from its toxicity. UNC0638 markedly reduced the clonogenicity of MCF7 cells, reduced the abundance of H3K9me2 marks at promoters of known G9a-regulated endogenous genes and disproportionately affected several genomic loci encoding microRNAs. Synonyms: UNC0638, UNC-0638, UNC 0638. Grades: 0.98. CAS No. 1255580-76-7. Molecular formula: C30H47N5O2. Mole weight: 509.739. | |
| UNC0638 hydrate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC0638 hydrate | UNC 0638 is a selective inhibitor of G9a/EHMT2 and GLP histone lysine methyltransferases (IC50 values are < 15 nM and 19 nM for G9a and GLP respectively, and> 10000 nM for a panel of other histone methyltransferases). UNC 0638 inhibits dimethylation of H3K9 in MCF-7 cells (IC50 = 70 nM). Synonyms: UNC 0638; UNC0638; UNC-0638; 2-Cyclohexyl-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine. Grades: ≥99% by HPLC. CAS No. 1255517-77-1. Molecular formula: C30H49N5O3. Mole weight: 527.7. | |
| UNC0642 | UNC0642 is a potent and selective lysine methyltransferases G9a and GLP inhibitor, with an IC50 of <2.5 nM for G9a. Uses: Scientific research. Group: Signaling pathways. CAS No. 1481677-78-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13980. | |
| UNC0642 | UNC0642 is a potent, selective inhibitor of G9a/GLP with improved PK properties. Synonyms: UNC0642; UNC-0642; UNC 0642. Grades: 98%. CAS No. 1481677-78-4. Molecular formula: C29H44F2N6O2. Mole weight: 546.71. | |
| UNC0642 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC0646 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC0646 | UNC-0646 is a novel G9a inhibitor with excellent potency in a variety of cell lines and excellent separation of functional potency versus cell toxicity. Synonyms: UNC0646, UNC 0646, UNC-0646. Grades: 0.98. CAS No. 1320288-17-2. Molecular formula: C36H59N7O2. Mole weight: 621.915. | |
| UNC 0646 | UNC 0646. Group: Biochemicals. Grades: Purified. CAS No. 1320288-17-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC10217938A | UNC10217938A is a 3-deazapteridine analog with strong oligonucleotide enhancing effects. UNC10217938A enhances oligonucleotides effects by modulating their intracellular trafficking and release from endosomes. UNC10217938A also enhances the effects of antisense and siRNA oligonucleotides[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1347749-97-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136151. | |
| UNC1215 | UNC1215 is a potent and selective inhibitor for the methyllysine (Kme) reading domain function of L3MBTL3 with a Kd value of 120 nM and an IC50 of 40 nM. UNC1215 has the potential to treat malignant brain tumor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1415800-43-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15649. | |
| UNC1215 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC1215 | UNC1215 is a potent, selective antagonist of L3MBTL3 with cellular activity. UNC1215 has an IC50 of 20 nM and > 100-fold selectivity over 13 HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. Synonyms: UNC1215, UNC-1215, UNC 1215; (2-(phenylamino)-1,4-phenylene)bis((4-(pyrrolidin-1-yl)piperidin-1-yl)methanone). Grades: >98%. CAS No. 1415800-43-9. Molecular formula: C32H43N5O2. Mole weight: 529.729. | |
| UNC 1215 | UNC 1215. Group: Biochemicals. Alternative Names: 2-Phenylamino-1, 4-[4- (pyrrolidinyl) piperidinyl) benzamide. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C32H43N5O2, Molecular Weight: 529.72. US Biological Life Sciences. | Worldwide |
| UNC1999 | UNC1999. Group: Biochemicals. Alternative Names: N-[(1,2-Dihydro-6-methyl-2-oxo-4-propyl-3-pyridinyl)methyl]-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-Indazole-4-carboxamide. Grades: Highly Purified. CAS No. 1431612-23-5. Pack Sizes: 5mg. Molecular Formula: C33H43N7O2, Molecular Weight: 569.74. US Biological Life Sciences. | Worldwide |
| UNC1999 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC1999 | UNC1999 is a SAM-competitive, potent and selective inhibitor of EZH2/1 with IC50s of <10 nM and 45 nM, repectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1431612-23-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15646. | |
| UNC-1999 | UNC1999, the first orally bioavailable inhibitor that has high in vitro potency for wildtype and mutant EZH2 as well as EZH1. UNC1999 was highly selective for EZH2 and EZH1 over a broad range of epigenetic and non-epigenetic targets. UNC1999 was orally bioavailable in mice, making this inhibitor a valuable tool for investigating the role of EZH2 and EZH1 in chronic animal studies. UNC-1999 represents a useful tools for the biomedical community to investigate the role of EZH2 and EZH1 in health and disease. Synonyms: UNC1999; UNC 1999; UNC-1999. Grades: 0.98. CAS No. 1431612-23-5. Molecular formula: C33H43N7O2. Mole weight: 569.754. | |
| UNC2025 | UNC2025 is a potent, ATP-competitive and highly orally active Mer/Flt3 inhibitor with IC50 values of 0.74 nM and 0.8 nM, respectively. UNC2025 is >45-fold selectivity for MERTK relative to Axl (IC50= 122 nM; Ki = 13.3 nM). UNC2025 exhibits an excellent PK properties, and can be used for the investigation of acute leukemia[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1429881-91-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12344. | |
| UNC-2025 | UNC-2025 is a novel potent and highly orally bioavailable Mer/FLT3 dual inhibitor, capable of inhibiting Mer phosphorylation in vivo, following oral dosing as demonstrated by pharmaco-dynamic (PD) studies examining phospho-Mer in leukemic blasts from mouse bone marrow. Kinome profiling versus more than 300 kinases in vitro and cellular selectivity assessments demonstrate that UNC-2025 has similar subnanomolar activity against Flt3, an additional important target in acute myelogenous leukemia (AML), with pharmacologically useful selectivity versus other kinases examined. Synonyms: Cyclohexanol, 4-[2-(butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]-, trans-; trans-4-[2-(Butylamino)-5-[4-[(4-methyl-1-piperazinyl)methyl]phenyl]-7H-pyrrolo[2,3-d]pyrimidin-7-yl]cyclohexanol; MRX 6313; UNC 2025; UNC2025. Grades: ≥95%. CAS No. 1429881-91-3. Molecular formula: C28H40N6O. Mole weight: 476.66. | |
| UNC-2025 hydrochloride | UNC-2025 hydrochloride is the hydrochloride salt of UNC-2025, which is the Mer/FLT3 dual inhibitor. Synonyms: UNC-2025 hydrochloride; UNC 2025 hydrochloride; UNC2025 hydrochloride; (1r,4r)-4-(2-(butylamino)-5-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-7H-pyrrolo[2,3-d]pyrimidin-7-yl)cyclohexanol hydrochloride. Grades: >98%. CAS No. 2070015-17-5. Molecular formula: C28H41ClN6O. Mole weight: 513.12. | |
| UNC-2170 | UNC-2170 is a functionally active, fragment-like ligand for 53BP1 ( IC 50 =29 μM; K d =22 μM). UNC-2170 shows at least 17-fold selectivity for 53BP1 as compared to nine other methyl-lysine (Kme) reader proteins. 53BP1 is a Kme binding protein that plays a central role in DNA Damage Repair (DDR) pathways and is recruited to sites of double-strand breaks (DSB) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648707-58-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-115531. | |
| UNC2170 maleate | UNC2170 is a p53-Binding protein 1 (53BP1) antagonist that binds to a pocket formed by the tandem tudor domains on a 53BP1 homodimer. Synonyms: 3-bromo-N-[3-(tert-butylamino)propyl]benzamide maleate. Grades: ≥95%. Molecular formula: C14H21BrN2O·C4H4O4. Mole weight: 429.3. | |
| UNC2170 trifluoroacetate | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC2250 | UNC2250 is a potent and selective Mer Kinase inhibitor. When applied to live cells, UNC2250 inhibited steady-state phosphorylation of endogenous Mer with an IC50 of 9.8 nM and blocked ligand-stimulated activation of a chimeric EGFR-Mer protein. Treatment with UNC2250 also resulted in decreased colony-forming potential in rhabdoid and NSCLC tumor cells. The results provide a rationale for further investigation of UNC2250 for therapeutic application in patients with cancer. Synonyms: UNC-2250; UNC 2250. Grades: 98%. CAS No. 1493694-70-4. Molecular formula: C24H36N6O2. Mole weight: 440.58. | |
| UNC2250 | UNC2250 is a potent and selective Mer inhibitor with an IC50 of 1.7 nM, about 160- and 60-fold selectivity over the closely related kinases Axl/Tyro3. Uses: Scientific research. Group: Signaling pathways. CAS No. 1493694-70-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15797. | |
| UNC 2327 | UNC 2327 is an allosteric inhibitor of protein arginine methyltransferase 3 (PRMT3) (IC50 = 230 nM). Synonyms: UNC2327; UNC-2327; UNC 2327; N-1,2,3-Benzothiadiazol-6-yl-N'-[2-oxo-2-(1-piperidinyl)ethyl]urea. Grades: ≥99% by HPLC. CAS No. 1426152-53-5. Molecular formula: C14H17N5O2S. Mole weight: 319.38. | |
| UNC 2327 | UNC 2327. Group: Biochemicals. Grades: Purified. CAS No. 1426152-53-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC2383 | UNC2383 is an oligonucleotide enhancer compound. UNC2383 can enhance the efficacy of antisense oligonucleotides (ASOs) and splice-switching oligonucleotides (SSOs). UNC2383 can be used in research of diseases involving impaired oligonucleotide delivery, such as cystic fibrosis[1][2][3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2123481-48-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-157261. | |
| UNC 2399 | | |
| UNC2400 | UNC2400 is a close analog of UNC1999 with >1,000-fold lower potency than UNC1999 as a negative control for cell-based studies[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1433200-49-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-12845. | |
| UNC 2400 | UNC 2400 is a negative control of UNC 1999 that displays 1000-fold lower potency than active analog (IC50 = 62 and >200 μM for EZH1 and EZH2, respectively). Synonyms: UNC2400; UNC-2400; UNC 2400; N-[(1,2-Dihydro-1,6-dimethyl-2-oxo-4-propyl-3-pyridinyl)methyl]-N-methyl-1-(1-methylethyl)-6-[6-[4-(1-methylethyl)-1-piperazinyl]-3-pyridinyl]-1H-indazole-4-carboxamide. Grades: ≥98% by HPLC. CAS No. 1433200-49-7. Molecular formula: C35H47N7O2. Mole weight: 597.79. | |
| UNC2541 | UNC2541 is a potent specific inhibitor of Mer tyrosine kinase (MerTK). Synonyms: UNC-2541; UNC 2541. Grades: ≥98% by HPLC. CAS No. 1612782-86-1. Molecular formula: C24H34FN7O2. Mole weight: 471.6. | |
| UNC2881 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC2881 | UNC2881 is a potent Mer kinase inhibitor. UNC2281 inhibits steady-state Mer kinase phosphorylation with an IC50 value of 22 nM. Treatment with UNC2281 is also sufficient to block EGF-mediated stimulation of a chimeric receptor containing the intracellular domain of Mer fused to the extracellular domain of EGFR. In addition, UNC2881 potently inhibits collagen-induced platelet aggregation, suggesting that this class of inhibitors may have utility for prevention and/or treatment of pathologic thrombosis. Synonyms: UNC2881; UNC 2881; UNC-2881. Grades: 98%. CAS No. 1493764-08-1. Molecular formula: C25H33N7O2. Mole weight: 463.586. | |
| UNC3230 | UNC3230 is a potent, selective and ATP-competitive PIP5K1C inhibitor with an IC50 of ~41 nM. UNC3230 also inhibits PIP4K2C and does not inhibit any of the other lipid kinases that regulate phosphoinositide levels. UNC3230 has antinociceptive and anticancer effects[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031602-63-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110150. | |
| UNC 3230 | UNC 3230. Group: Biochemicals. Grades: Purified. CAS No. 1031602-63-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| UNC 3230 | UNC 3230 is a potent and selective PIP5K1C inhibitor (IC50 = 41 nM), displaying selectivity for PIP5K1C over PIP5K1A, the PI 3-kinase family and a panel of other kinases. UNC 3230 decreases PIP2 levels and LPA-induced calcium signaling in dorsal root ganglia (DRG) neurons in vitro. UNC 3230 exhibits antinociceptive effects in mouse models of chronic pain. Synonyms: UNC3230; UNC-3230; UNC 3230; 5-[(Cyclohexylcarbonyl)amino]-2-(phenylamino)-thiazolecarboxamide. Grades: ≥99% by HPLC. CAS No. 1031602-63-7. Molecular formula: C17H20N4O2S. Mole weight: 344.43. | |
| UNC3474 | UNC3474 is a small molecule ligand, binding with 53BP1. UNC3474 binds the aromatic methyl-lysine binding cage of 53BP1TT, with a dissociation constant (Kd) of 1.0?±?0.3 ?M. UNC3474 inhibits the recruitment of 53BP1 to DSBs by stabilizing a pre-existing autoinhibited state of 53BP1 in cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1648707-79-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-156906. | |
| UNC 3866 | UNC 3866 is a potent and high affinity CBX4 and CBX7 inhibitor (Ki = 94 and 97 nM, respectively) displaying > 6-fold selectivity over other CBX and CDY family members. UNC 3866 was shown to inhibit the proliferation of PC3 cells in vitro. Synonyms: UNC3866, UNC-3866, UNC 3866; N-[4-(1,1-Dimethylethyl)benzoyl]-L-phenylalanyl-L-alanyl-L-leucyl-N6,N6-diethyl-L-lysyl-L-serine methyl ester. CAS No. 1872382-47-2. Molecular formula: C43H66N6O8. Mole weight: 795.02. | |
| UNC3866 trifluoroacetate salt | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| UNC5293 | UNC5293 is a MERTK-selective and potent inhibitor (Ki=190 pM). UNC5293 inhibits MERTK (IC50=0.9 nM) and is more selective over Axl, Tyro3 and Flt3. UNC5293 exhibits excellent mouse PK properties and is used for bone marrow leukemia research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2226789-82-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132200. | |
| UNC569 | UNC569 is a potent, reversible, ATP-competitive and orally active Mer kinase inhibitor with an IC50 of 2.9 nM and a Ki of 4.3 nM. UNC569 also inhibits Axl and Tyro3 with IC50s of 37 nM and 48 nM, respectively. UNC569 can be used for acute lymphoblastic leukemia (ALL) and atypical teratoid/rhabdoid tumors research[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1350547-65-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-117596. | |
| UNC569 | Mer proto-oncogene tyrosine kinase (MerTK) is expressed in the retinal pigment epithelium (RPE), regulates phagocytosis of shed photoreceptor outer segments (POS). UNC569 is a specific MerTK inhibitor. Synonyms: 1-[(Trans-4-Aminocyclohexyl)methyl]-N-Butyl-3-(4-Fluorophenyl)-1h-Pyrazolo[3,4-D]pyrimidin-6-Amine. Grades: 98%. CAS No. 1350547-65-7. Molecular formula: C22H29FN6. Mole weight: 396.50. | |
| UNC 669 | (5-Bromopyridin-3-yl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone is a selective inhibitor of malignant brain tumor (MBT). Synonyms: UNC669; UNC-669. Grades: >98%. CAS No. 1314241-44-5. Molecular formula: C15H20BrN3O. Mole weight: 338.24. | |
| UNC6852 | UNC6852 is a selective polycomb inhibitory complex 2 (PRC2) degradation agent based on PROTAC. Synonyms: UNC-6852; UNC 6852; (2S,4R)-1-((S)-2-(4-(4-(5-((Furan-2-ylmethyl)amino)-[1,2,4]triazolo[4,3-c]pyrimidin-8-yl)benzamido)butanamido)-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide. Grades: ≥98% by HPLC. CAS No. 2688842-08-0. Molecular formula: C43H48N10O6S. Mole weight: 832.99. | |
| UNC6852 | UNC6852 is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC and contains an EED (embryonic ectoderm development) ligand and a von Hippel-Lindau ligand, with an IC50 of 247 nM for EED[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2688842-08-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-130708. | |
| UNC6934 | UNC6934, a chemical probe targeting the PWWP domain, alters NSD2 nucleolar localization. Uses: Scientific research. Group: Signaling pathways. CAS No. 2561494-77-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-145103. | |
| UNC6934 | UNC6934 is a novel potent antagonist of NSD2-PWWP1 with a Kd (SPR) of 80 ± 18 nM, being selective for NSD2-PWWP1 over 14 other PWWP domains including NSD3-PWWP1, the closest on the phylogenetic tree, disrupting the NSD2-PWWP1 interaction with H3K36me2 nucleosomes in U2OS cells. Uses: Designed for use in research and industrial production. Additional or Alternative Names: UNC6934; UNC-6934; UNC 6934. Product Category: Antagonists. Appearance: Solid powder. CAS No. 2561494-77-5. Molecular formula: C24H21N5O4. Mole weight: 443.46. Purity: >98%. IUPACName: N-Cyclopropyl-3-oxo-N-(4-(pyrimidin-4-ylcarbamoyl)benzyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-carboxamide. Canonical SMILES: O=C(C1=CC=C(N2)C(OCC2=O)=C1)N(C3CC3)CC4=CC=C(C(NC5=NC=NC=C5)=O)C=C4. Product ID: ACM2561494775. Alfa Chemistry ISO 9001:2015 Certified. |  |
| UNC7467 | UNC7467 is a potent IP6K inhibitor with values of 4.9, 8.9 and 1320 nM for IP6K2, IP6K1 and IP6K6, respectively. UNC7467 reduces levels of inositol pyrophosphates. UNC7467 can be used for obesity research[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2922283-43-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-150607. | |
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