A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
WS75624 B is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 75624. It also showed other metalloprotease (collagenase and neutral endopeptidase) inhibitory activity with IC50 value of 1 mM/ml. Synonyms: WS-75624 B; WS 75624 B; WS-75624B. Molecular formula: C18H24N2O5S. Mole weight: 380.5.
WS79089 A
WS79089 A is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 79089. Synonyms: WS-79089 A; WS 79089 A; WS-79089A. CAS No. 157110-23-1. Molecular formula: C27H20O9. Mole weight: 488.4.
WS79089 B
WS79089 B is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 79089. The activity of B is more potent than that of A and C. Synonyms: WS-79089 B; WS 79089 B; WS-79089B. CAS No. 157110-24-2. Molecular formula: C27H22O10. Mole weight: 506.5.
WS79089 C
WS79089 C is an endothelin converting enzyme (ECE) inhibitor isolated from the fermentation broth of Saccharothrix sp. No. 79089. Synonyms: WS-79089 C; WS 79089 C; WS-79089C. CAS No. 157110-25-3. Molecular formula: C29H22O10. Mole weight: 530.5.
WS9326A
WS9326A is a tachykinin antagonist from Streptomyces violaceusniger No. 9326. Synonyms: WS-9326A. Molecular formula: C54H68N8O13. Mole weight: 1037.2.
WS-9659 B
WS-9659 B is a testosterone 5 alpha-reductase inhibitor isolated from Streptomyces sp. No. 9659. It exhibits weak activity against gram-positive bacteria. Synonyms: WS-9659B; WS 9659 B. CAS No. 123313-61-1. Molecular formula: C22H23ClN2O. Mole weight: 366.9.
WS-9761 A
WS-9761 A is a non-steroidal androgen-receptor antagonist produced by Streptomyces sp. No. 9761. Synonyms: WS-9761A; WS 9761A; WS9761A. CAS No. 154163-89-0. Molecular formula: C17H16O4. Mole weight: 284.31.
WS-9761 B
WS-9761 B is a non-steroidal androgen-receptor antagonist produced by Streptomyces sp. No. 9761. Synonyms: WS-9761B; WS 9761B; WS9761B. CAS No. 154163-90-3. Molecular formula: C17H16O5. Mole weight: 300.3.
WST-1 is a kind of water-soluble tetrazolium salt. WST induces the intracellular mitochondrial dehydrogenase to conduct NADH-dependent enzyme digestion reaction, releasing the water-soluble methyl benzene product. WST-1 can be used for the detection of cell proliferation and cytotoxicity, via the determination of the light absorption value at 450 nm [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 150849-52-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-136976.
WST-1 (Water-soluble Tetrazolium 1)
A highly sensitive tetrazolium reagent (light red) that produces a water-soluble formazan (dark red color) in NADH and cell proliferation assays due to cleavage by mitochondrial dehydrogenase. Group: Biochemicals. Alternative Names: Water-soluble Tetrazolium 1; 4-[3-(4-Iodophenyl)-2-(4-nitrophenyl)-2H-5-tetrazolio]-1,3-benzene Disulfonate; 5-(2,4-Disulfophenyl)-2-(4-iodophenyl)-3-(4-nitrophenyl)-2H-tetrazolium Inner Salt Sodium Salt (1:1). Grades: Highly Purified. CAS No. 150849-52-8. Pack Sizes: 100mg, 250mg. US Biological Life Sciences.
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WST-3
WST-3. Group: Biochemicals. Alternative Names: 4-[3-(4-Iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzene disulfonate; 3-(2,4-Dinitrophenyl)-5-(2,4-disulfophenyl)-2-(4-iodophenyl)-2H-tetrazolium Inner Salt Sodium Sal. Grades: Highly Purified. CAS No. 515111-36-1,161617-45-4. Pack Sizes: 50mg, 100mg, 250mg, 500mg, 1g. Molecular Formula: C19H10IN6NaO10S2. US Biological Life Sciences.
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WST-3
WST-3 is a water-soluble tetrazolium dye. In the presence of an electron mediator, WST-3 is reduced to WST-3 formazan by NADH and displays an absorption maxima of 433 nM [1]. Uses: Scientific research. Group: Fluorescent dye. CAS No. 515111-36-1. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-125921.
A highly sensitive tetrazolium reagent (light red) that produces a water-soluble formazan (dark red color). WST-3 formazan l max = 433nm; e= 3.1x10e4Suitable for detection of dehydrogenases. Group: Biochemicals. Alternative Names: 4-[3-(4-Iodophenyl)-2-(2,4-dinitrophenyl)-2H-5-tetrazolio]-1,3-benzene Disulfonate; 3-(2,4-Dinitrophenyl)-5-(2,4-disulfophenyl)-2-(4-iodophenyl)-2H-tetrazolium Inner Salt Sodium Salt; IPB. Grades: Highly Purified. CAS No. 161617-45-4. Pack Sizes: 50mg, 100mg, 250mg. Molecular Formula: C??H??IN?NaO??S?, Molecular Weight: 696.34. US Biological Life Sciences.
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WST-8
A highly sensitive tetrazolium reagent that produces a water-soluble formazan (orange color that absorbs at 460 nm) in NADH. It is newer generation formazan-based dyes which release the converted product into the medium in a soluble form allowing for a non-destructive determination of viability enabling the cells to be subject to further investigations. Group: Biochemicals. Alternative Names: 5-(2,4-Disulfophenyl)-3-(2-methoxy-4-nitrophenyl)-2-(4-nitrophenyl)-2H-tetrazolium Inner Salt Sodium Salt. Grades: Highly Purified. CAS No. 193149-74-5. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C20H13N6O11S2 Na. US Biological Life Sciences.
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WST-8
WST-8 is a water-soluble tetrazolium dye, WST-8 enhances sensitivity of the WST-8-based assay over the conventional MTS-based assay. Uses: Scientific research. Group: Fluorescent dye. CAS No. 193149-74-5. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-D0831.
WT-161 is a potent and specific HDAC6 inhibitor (IC50 = 0.40 nM). Consistent with WT-161 mediated hyperacetylation and inhibition of hsp90 chaperone function, treatment with WT-161 increased the intracellular levels of polyubiuitylated proteins in the cultured MCL JeKo-1 and Z138 cells. WT-161 was also noted to dose-dependently deplete the levels of cyclin D1 in the cultured MCL cells. Uses: Antineoplastic agents. Synonyms: (E) -8- (2- (4- (Diphenylamino) benzylidene) hydrazinyl) -N-hydroxy-8-oxooctanamide; WT161; WT 161; WT-161. CAS No. 1206731-57-8. Molecular formula: C27H30N4O3. Mole weight: 458.55.
WTe2 Crystal
Graphene-like Materials Series. CAS No. 12067-76-4. Purity: 0.99995. Catalog: ACM12067764.
Wulignan A1
Wulignan A1. Group: Biochemicals. Grades: Plant Grade. CAS No. 117047-76-4. Pack Sizes: 5mg. Molecular Formula: C20H22O5, Molecular Weight: 342.39. US Biological Life Sciences.
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WUN40378
WUN40378 is compound first reported in PCT Int. Appl. (2019), WO 201909959, in which it was described as CBFβ-RUNX1 inhibitor. WUN40378 is very similar to Ro 5-3335 but with an F instead of Cl. WUN40378 is also analog of Ro 24-7429. Group: Inhibitors. Alternative Names: WUN40378; WUN 40378; WUN-40378; Ro5-3335 analog; Ro 5-3335 analog; Ro 5-3335 analog; Ro 24-7429 analog; Ro 24-7429 analog; Ro24-7429 analog. CAS No. 2328140-37-8. Molecular formula: C13H10FN3O. Mole weight: 243.24. Appearance: Solid powder. Purity: >98%. IUPACName: 7-fluro-1,3-dihydro-5-(1H-pyrrol-2yl)-2H-1,4-benzodiazepin-2-one. Canonical SMILES: O=C1NC2=CC=C(F)C=C2C(C3=CC=CN3)=NC1. Catalog: ACM2328140378.
WUN55267
WUN55267, also known as GPR40/FFAR1 modulator 1, is an agonist and an allosteric modulator for Gq-coupled free fatty acid receptor 1 (GPR40/FFAR1). This product has no formal name at the moment. Group: Agonists. Alternative Names: GPR40/FFAR1 modulator 1; WUN55267; WUN-55267; WUN 55267. CAS No. 874755-26-7. Molecular formula: C21H19N5O3. Mole weight: 389.42. Appearance: To be determined. Purity: >98%. IUPACName: 7-((4-amino-6-(o-tolylamino)-1,3,5-triazin-2-yl)methoxy)-4-methyl-2H-chromen-2-one. Canonical SMILES: CC1=CC=CC=C1NC2=NC (COC3=CC=C (C (C)=CC (O4)=O)C4=C3)=NC (N)=N2. Catalog: ACM874755267.
WWL 113
WWL 113 is a carboxylesterase Ces3 and Ces1f inhibitor (IC50 = ~100 nM) with minimal activity against a panel of other serine hydrolases. WWL 113 was indicated ability to reduce weight gain in diet-induced obese mice and potentiate glucose tolerance in diabetic mice. It significantly reduces basal lipolysis in adipocytes. Synonyms: WWL113; WWL-113; WWL 113; 4'-[[[Methyl[[3- (4-pyridinyl) phenyl]methyl]amino]carbonyl]oxy]-[1, 1'-biphenyl]-4-carboxylic acid ethyl ester. Grades: ≥99% by HPLC. CAS No. 947669-86-5. Molecular formula: C29H26N2O4. Mole weight: 466.53.
WWL 113
WWL 113. Group: Biochemicals. Grades: Purified. CAS No. 947669-86-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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WWL123
WWL123 is a brain-penetrant inhibitor of ABHD6 (IC50 = 0.43 μM) exhibiting >10-fold selectivity for ABHD6 compared to a panel of ~35 other serine hydrolases. WWL123 has been used to decrease seizure incidence in a genetic mouse model of juvenile Huntington's disease as well as in chemically-induced epilepsy models. Synonyms: [3-(4-carbamoylphenyl)phenyl] N-methyl-N-[(3-phenylphenyl)methyl]carbamate. Grades: ≥95%. CAS No. 1338575-41-9. Molecular formula: C28H24N2O3. Mole weight: 436.5.
WWL 123
WWL 123 is an α/β-hydrolase domain 6 (ABHD6) inhibitor (IC50 = 0.43 μM) with antiepileptic activity. It suppresses PTZ-induced seizures in healthy mice and spontaneous seizures in R6/2 mice. Synonyms: WWL123; WWL-123; WWL 123; N-[[1,1'-Biphenyl]-3-ylmethyl)-N-methylcarbamic acid 4'-(aminocarbonyl)[1,1'-biphenyl]-4-yl ester. Grades: ≥98% by HPLC. CAS No. 1338574-83-6. Molecular formula: C28H24N2O3. Mole weight: 436.5.
WWL229
WWL229 is a selective inhibitor of Ces3 (carboxylesterase-3). It inhibits the triglyceride hydrolase activity of Ces3, promotes lipid storage in cultured adipocytes and prevents basal lipolysis. Synonyms: (4-Nitrophenyl) 2-(3-methoxypropyl)piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1338575-28-2. Molecular formula: C16H22N2O5. Mole weight: 322.4.
WWL70
WWL70 is a potent inhibitor of α/β-hydrolase domain 6 (ABHD6) (IC50 = 70 nM). ABHD6 is a serine hydrolase that is highly expressed in mammalian brain. Synonyms: 4'-carbamoyl-[1,1'-biphenyl]-4-yl methyl(3-(pyridin-4-yl)benzyl)carbamate; WWL 70; WWL70; WWL-70. CAS No. 947669-91-2. Molecular formula: C27H23N3O3. Mole weight: 437.5.
WWL 70
WWL 70. Group: Biochemicals. Grades: Purified. CAS No. 947669-91-2. Pack Sizes: 10mg. US Biological Life Sciences.
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WY 14643
WY 14643. Group: Biochemicals. Grades: Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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WY-14643
Potent peroxisome proliferator-activated receptor (PPARalpha) activator. Activates also PPARgamma but not PPARdelta. Potent anti-hypercholesterolemic agent. Hypolipidemic compound. Lipogenesis inducer. Tumor promoter. Causes increased cell proliferation and decreased apoptosis. Anti-inflammatory. Inhibits NF-kappaB transcriptional activity and decreases the inflammatory response by reducing the production of inflammatory cytokines (TNF-alpha, IL1beta). Reduces oxidative stress. Increases fatty acid oxidation. Directly affects insulin signaling. Increases glucose uptake. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg, 250mg. Molecular Formula: C14H14ClN3O2S. US Biological Life Sciences.
Cell-permeable. A selective PPARa agonist (EC50 values are 0.63, 32 and > 100uM at PPARa, PPARg and PPARd respectively. Group: Biochemicals. Grades: Highly Purified. CAS No. 50892-23-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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WY 45233 succinate
WY 45233 succinate is an inhibitor of serotonin and noradrenalin reuptake (SNRI) used in the treatment of major depressive disorder (MDD). WY 45233 succinate inhibits [3H]5-HT and [3H]NE uptake (IC50 = 47.3 and 531.3 nM). Uses: The treatment of major depressive disorder. Synonyms: WY 45233 succinate; WY45233 succinate; WY-45233 succinate; 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol succinate; O-Desmethylvenlafaxine succinate; Ventab DXT; Desvenlafaxine succinate anhydrous. Grades: ≥99% by HPLC. CAS No. 448904-47-0. Molecular formula: C16H25NO2.C4H6O4. Mole weight: 381.46.
wybutosine
A modified nucleoside of phenylalanine tRNA. Synonyms: 3H-Imidazo[1,2-a]purine-7-butanoic acid, 4,9-dihydro-a-[(methoxycarbonyl)amino]-4,6-dimethyl-9-oxo-3-b-D-ribofuranosyl-, methyl ester, (S)-. Grades: ≥98%. CAS No. 55196-46-8. Molecular formula: C21H28N6O9. Mole weight: 508.49.
WYE-125132
WYE-125132, also known as WYE-132, is a highly potent, ATP-competitive, and specific mTOR kinase inhibitor. WYE-132 inhibited mTORC1 and mTORC2 in diverse cancer models in vitro and in vivo. Importantly, consistent with genetic ablation of mTORC2, WYE-132 targeted P-AKT(S473) and AKT function without significantly reducing the steady-state level of the PI3K/PDK1 activity biomarker P-AKT(T308), highlighting a prominent and direct regulation of AKT by mTORC2 in cancer cells. Synonyms: WYE 125132, WYE-125132, WYE125132, WYE132, WYE 132, WYE-132. Grades: 0.98. CAS No. 1144068-46-1. Molecular formula: C27H33N7O4. Mole weight: 519.606.
WYE-23
WYE-23 is an inhibitor of mTOR with IC50 value of 0.45 nM. Synonyms: mTOR Inhibitor WYE-23; Methyl 4-[6-[4-(cyclopropylcarbamoylamino)phenyl]-4-morpholin-4-ylpyrazolo[3,4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1062169-46-3. Molecular formula: C26H32N8O4. Mole weight: 520.6.
WYE-28
WYE-23 is an ATP-competitive inhibitor of mTOR with IC50 value of 0.08 nM. Synonyms: Methyl 4-[6-[4-[[4- (hydroxymethyl) phenyl]carbamoylamino]phenyl]-4-morpholin-4-ylpyrazolo[3, 4-d]pyrimidin-1-yl]piperidine-1-carboxylate. Grades: ≥98%. CAS No. 1062172-60-4. Molecular formula: C30H34N8O5. Mole weight: 586.6.
WYE-354
WYE-354 is a potent cell-permeable inhibitor of mTOR (IC50 = 4.3 nM) which blocks signaling through both mTOR complex 1 (mTORC1) and mTORC2. Synonyms: WYE354; WYE-354; WYE 354. Grades: 0.98. CAS No. 1062169-56-5. Molecular formula: C24H29N7O5. Mole weight: 495.54.
WYE 672
WYE 672 is a tissue selective liver X receptor (LXR) agonist selectively binds to LXRα (IC50 >1.0 μM). Synonyms: WYE 672; WYE672; WYE-672; 3-methyl-2-[4-(3-methylsulfonylphenyl)phenyl]-5-(trifluoromethyl)quinoxaline. Grades: 99%. CAS No. 1221265-37-7. Molecular formula: C23H17F3N2O2S. Mole weight: 442.45.
WYE-687
WYE-687 is an ATP-competitive and selective inhibitor of mammalian target of rapamycin (mTOR). Studies have shown the combination of Ras-Raf-MEK1/2 inhibitors with WYE-687 may overcome resistance to mTorKIs thus may be an effective additive therapy for treatment of patient with renal cell carcinoma or colorectal cancer. Group: Biochemicals. Alternative Names: Methyl 4-(4-morpholino-1-(1-(pyridin-3-ylmethyl)piperidin-4-yl)-1H-pyrazolo[3,4-d] pyrimidin-6-yl)phenylcarbamate Acid. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 5mg. US Biological Life Sciences.
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WYE-687
WYE-687 is a potent and ATP-competitive and selective inhibitor of mTOR with IC50 of 7 nM. Synonyms: WYE687; WYE 687; WYE-687. Grades: 0.98. CAS No. 1062161-90-3. Molecular formula: C28H32N8O3. Mole weight: 528.617.
WYE 687 dihydrochloride
WYE 687 is an ATP-competitive inhibitor of mTOR with IC50 value of 7 nM. It was shown to inhibit phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt. It also blocks VEGF secretion and HIF-1α expression. Synonyms: N-[4-[4-(4-Morpholinyl)-1-[1-(3-pyridinylmethyl)-4-piperidinyl]-1H-pyrazolo[3,4-d]pyrimidin-6-yl]phenyl]-carbamic acid methyl ester dihydrochloride. Grades: ≥98% by HPLC. CAS No. 1702364-87-1. Molecular formula: C28H32N8O32HCl. Mole weight: 601.53.
Potent, ATP-competitive inhibitor of mammalian target of rapamycin (mTOR) (IC50 = 7nm). Displays selectivity for mTOR over PI 3-Kalpha (~100-fold) and PI 3-Kgamma (~500-fold). Inhibits phosphorylation of mTORC1 and mTORC2 substrates including S6K, SGK and Akt; blocks VEGF secretion and HIF-1alpha expression. Exhibits antiproliferative effects in cancer cell lines through G1 cell cycle arrest and selective apoptosis. Group: Biochemicals. Grades: Highly Purified. CAS No. 1062161-90-3. Pack Sizes: 10mg. US Biological Life Sciences.
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wyosine
Wyosine is a compound commonly found in transfer RNA (tRNA) molecules. It plays a significant role in stabilizing the anticodon loop of tRNA aiding in accurate protein synthesis. Wyosine has been studied in various diseases, such as cancer and viral infections, due to its involvement in tRNA function and cellular processes. Synonyms: 9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-4,6-dimethyl-3-b-D-ribofuranosyl-; {3H-Diimidazo[1,2-a:4',5'-d]pyrimidin-9-one} 4,9-dihydro-4,6-dimethyl-3-B-D-ribofuranosyl-; 3-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-4,6-dimethyl-imidazo[1,2-a]purin-9-one. CAS No. 52662-10-9. Molecular formula: C14H17N5O5. Mole weight: 335.32.
WZ-3146
WZ-3146 is an irreversiblely inhibitor against EGFR T790M with potential anticancer activity. Synonyms: WZ3146; WZ 3146. Grades: 0.98. CAS No. 1214265-56-1. Molecular formula: C24H25ClN6O2. Mole weight: 464.954.
WZ-4002
WZ-4002 is an EGFR phosphorylation inhibitor with selectivity for EGFR T790M. It has a framework of pyrimidine compound which is different from other EGFR inhibitors. WZ-4002 exhibits anti-tumor activity. Uses: Protein kinase inhibitors. Synonyms: WZ4002; N-(3-(5-chloro-2-(2-methoxy-4-(4-methylpiperazin-1-yl)phenylamino)pyrimidin-4-yloxy)phenyl)acrylamide; WZ 4002. CAS No. 1213269-23-8. Molecular formula: C25H27ClN6O3. Mole weight: 494.98.
WZ4003
WZ4003 exhibits a high, specific affinity to the L858R/T790M mutant EGFR, while a significantly reduced cellular IC50 against T790M containing Ba/F3 cells. Synonyms: WZ4003; WZ-4003; WZ 4003. Grades: >98%. CAS No. 1214265-58-3. Molecular formula: C25H29ClN6O3. Mole weight: 496.99.
WZ 4003
WZ 4003. Group: Biochemicals. Grades: Purified. CAS No. 1214265-58-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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WZ-8040
WZ8040 is a novel mutant-selective irreversible EGFRT790M inhibitor with potential anticancer activity. WZ8040 is about 30-fold more potent against EGFR T790M, and up to 100-fold less potent against wild-type EGFR, than other quinazoline-based EGFR inhibitors such as CL-387785 and HKI-272. WZ-8040 may be clinically more effective and better tolerated than quinazoline-based inhibitors. Synonyms: WZ8040; WZ 8040. Grades: 0.98. CAS No. 1214265-57-2. Molecular formula: C24H25ClN6OS. Mole weight: 481.015.
WZ 811
WZ 811 is a potent CXCR2 antagonist. Synonyms: N,N'-di-2-pyridinyl-1,4-benzenedimethanamine; WZ811; WZ-811; WZ 811. CAS No. 55778-02-4. Molecular formula: C18H18N4. Mole weight: 290.36.
WZ 811
WZ 811. Group: Biochemicals. Grades: Purified. CAS No. 55778-02-4. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
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WZB117
WZB117 is a glucose transporter 1 ( Glut1 ) inhibitor, which downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Uses: Scientific research. Group: Signaling pathways. CAS No. 1223397-11-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19331.
WZB 117
WZB 117 is a GLUT inhibitor (Ki(app) = 0.2, 10 and 10 μM for GLUT4, GLUT1 and GLUT3, respectively) that inhibits passive glucose transport in human erythrocytes and cancer cell lines. It decreases extracellular lactate and intracellular ATP levels. WZB 117 was shown to attenuate erythrocyte 3-O-metylglucose (3MG) uptake in vitro (Ki = 6 μM) and inhibits tumor growth in a nude mouse model. Synonyms: WZB117; WZB-117; WZB 117; 3-Fluoro-1,2-phenylene bis(3-hydroxybenzoate). Grades: ≥98% by HPLC. CAS No. 1223397-11-2. Molecular formula: C20H13FO6. Mole weight: 368.31.