A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
WIN 68577 is a nonpeptide antagonist of Neurokinin, which is isolated from Aspergillus sp. SC230. Synonyms: WIN 68577; Cyclo(glycyl-L-tryptophyl-L-prolylglycyl-L-valylglycyl-beta-hydroxy-L-tyrosyl). CAS No. 151928-33-5. Molecular formula: C36H44N8O9. Mole weight: 732.8.
An intermediate used in the preparation of Vitamin D derivatives. Group: Biochemicals. Alternative Names: (1R,3aR,7aR)-Octahydro-7a-methyl-1-[(1R,2E,4R)-1,4,5-trimethyl-2-hexen-1-yl]-4H-inden-4-one; [1R-[1α(1R*, 2E, 4R*), 3a β,7aα]]-Octahydro-7a-methyl-1-(1,4,5-trimethyl-2-hexenyl)-4H-inden-4-one. Grades: Highly Purified. CAS No. 55812-80-1. Pack Sizes: 50mg. US Biological Life Sciences.
Worldwide
Windaus Ketone
Windaus Ketone is an impurity of vitamin D2, which is commonly used for the prevention and treatment of vitamin D deficiency and associated disease, and also used for hypoparathyroidism. Synonyms: Ergocalciferol Impurity 1; Vitamin D2 Impurity 1; (1R,3aR,7aR)-1-[(E,2R,5R)-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-one. CAS No. 55812-80-1. Molecular formula: C19H32O. Mole weight: 276.464.
Winsteard's Reagent
Iron and nickel base alloys. Group: Etchants.
Winter flounder 1
Winter flounder 1 is an antibacterial peptide isolated from Pseudopleuronectes americanus. It has activity against gram-positive bacteria, gram-negative bacteria and fungi. Synonyms: NRC-1 peptide; H-Gly-Lys-Gly-Arg-Trp-Leu-Glu-Arg-Ile-Gly-Lys-Ala-Gly-Gly-Ile-Ile-Ile-Gly-Gly-Ala-Leu-Asp-His-Leu-OH. Grades: >96%. Molecular formula: C112H188N36O28. Mole weight: 2486.96.
Wiskostatin. Group: Biochemicals. Grades: Purified. CAS No. 253449-04-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Wiskostatin
Wiskostatin is a cell-permeable and selective inhibitor of neural Wiskott-Aldrich syndrome protein (N-WASP). Wiskostatin directly interacts with the regulatory GTPase-binding domain of N-WASP and inhibits its activation. Wiskostatin blocks the activation of Arp2/3 complex and inhibits actin polymerization. Synonyms: 3,6-Dibromo-α-[(dimethylamino)methyl]-9H-cabazole-9-ethanol; 1-(3,6-dibromocarbazol-9-yl)-3-(dimethylamino)propan-2-ol. Grades: ≥99% by HPLC. CAS No. 253449-04-6. Molecular formula: C17H18Br2N2O. Mole weight: 426.15.
Wiskott-Aldrich syndrome protein (262-281)
Wiskott-Aldrich syndrome protein (262-281) is a peptide derived from Wiskott-Aldrich syndrome protein. In addition to its role in the cytoplasmic cytoskeleton, it also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. Synonyms: WASp (262-281).
WITCAMIDE (R) 511 EMULSIFIER
Cas No. 80893-63-6.
Witch Hazel
Try this formula if youre looking to fight redness and inflammation, while also addressing combination or oily skin. Pack Sizes: 1 kg. Product ID: CDC10-0561. Category: Anti-Acne Ingredients. Product Keywords: Cosmetic Ingredients; Active Ingredients; Anti-Acne Ingredients; Witch Hazel; CDC10-0561.
Witch Hazel P.E. 4:1
Witch Hazel P.E. 4:1.
CA, FL & NJ
Withaferin A
Withaferin A is a steroidal lactone isolated from Withania somnifera , inhibits NF-kB activation and targets vimentin , with potent antiinflammatory and anticancer activities. Withaferin A is an inhibitor of endothelial protein C receptor (EPCR) shedding. Uses: Scientific research. Group: Natural products. CAS No. 5119-48-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg. Product ID: HY-N2065.
Withaferin A
Withaferin A is a promising anticancer constituent of Ayurvedic medicinal plant Withania somnifera. Withaferin A showed potent cytotoxicity against human head and neck squamous cell carcinoma (JMAR and MDA-1986). Group: Biochemicals. Alternative Names: (4 β,5 β,6 β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oic Acid δ-Lactone; (20S,22R)-5,6 β-Epoxy-4 β,22,27-trihydroxy-1-oxo-5 β-ergosta-2,24-dien-26-oic Acid δ-Lactone; NSC 101088; NSC 273757; Withaferine; Withaferine A. Grades: Highly Purified. CAS No. 5119-48-2. Pack Sizes: 1mg, 5mg. US Biological Life Sciences.
Worldwide
Withaferin A
Withaferin A. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Nsc 101088. Product Category: Heterocyclic Organic Compound. CAS No. 5119-48-2. Molecular formula: C28H38O6. Mole weight: 470.59. Purity: 0.95. Canonical SMILES: CC1=C(C(=O)O[C@H](C1)[C@@H](C)[C@H]2CC[C@@H]3[C@@]2(CC[C@H]4[C@H]3C[C@@H]5[C@]6([C@@]4(C(=O)C=C[C@@H]6O)C)O5)C)CO. Density: 1.28. Product ID: ACM5119482. Alfa Chemistry ISO 9001:2015 Certified.
Withaferin A
Withaferin A, also referred to as D004, NSC 101088, used as an important medicinal herb for over 3000 years, is a steroidal lactone derived from Acnistus arborescens, Withania somnifera and other members of Solanaceae family. This natural product has wide range of pharmacological application comprising of anti-obesity, anti-inflammatory, anti-neoplastic, antiangiogenic, etc. It inhibits NF-kB activation and targets vimentin. Synonyms: NSC 273757; UNII-L6DO3QW4K5; D004; NSC 101088. Grades: ≥96%. CAS No. 5119-48-2. Molecular formula: C28H38O6. Mole weight: 470.60.
Withanolide A
Withanolide A. Group: Biochemicals. Alternative Names: (5α, 6α, 7α, 22R)-6, 7-epoxy-5, 20, 22-trihydroxy-1-oxo-ergosta-2, 24-dien-26-oic Acid δ-Lactone; (22R)-6α,7α-epoxy-5,20,22-trihydroxy-1-oxo-5α-Ergosta-2,24-dien-26-oic Acid δ-Lactone; 6, 7-Epoxy-1H-cyclopenta [a]phenanthrene Ergosta-2,24-dien-26-oic Acid Deriv.; 5,20α-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide; 5α,20αF(R)-Dihydroxy-6α,7α-epoxy-1-oxowitha-2,24-dienolide; Withaniol. Grades: Highly Purified. CAS No. 32911-62-9. Pack Sizes: 10mg. Molecular Formula: C28H38O6, Molecular Weight: 470.6. US Biological Life Sciences.
Worldwide
Withanolide A
Withanolide A is an orally active extract from the Indian herb Ashwagandha. Withanolide A can induce apoptosis. Withanolide A has anti-inflammatory and antitumor activity. Withanolide A can be used in the study of neurodegenerative diseases [1] [2] [3] [4]. Uses: Scientific research. Group: Natural products. CAS No. 32911-62-9. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-N7028.
Withanolide B
Withanolide B is a withanolide that has been found in W. somnifera. Unlike withanolide A, it does not increase glucose uptake in L6 myotubes. In in silico docking studies, withanolide B acts as a neuronal nitric oxide synthase (nNOS) inhibitor (Ki = 5.15 nM). Synonyms: Lycium substance B. Grades: ≥95%. CAS No. 56973-41-2. Molecular formula: C28H38O5. Mole weight: 454.6.
Withanone
Withanone is an active constituent from Withania somnifera roots with multifunctional neuroprotective effect in alleviating cognitive dysfunction. Withanone affords protection against N-methyl-D-aspartate (NMDA) -induced excitotoxicity in Neuron-like cells [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 27570-38-3. Pack Sizes: 1 mg; 5 mg. Product ID: HY-129692.
Withanoside IV
Withanoside IV. Group: Biochemicals. Alternative Names: (1α,3 β,22R)-3-[(6-O- β-D-Glucopyranosyl- β-D-glucopyranosyl)oxy]-1,22,27-trihydroxy-ergosta-5,24-dien-26-oic Acid δ-Lactone. Grades: Highly Purified. CAS No. 362472-81-9. Pack Sizes: 1mg. Molecular Formula: C40H62O15, Molecular Weight: 782.91. US Biological Life Sciences.
Worldwide
WK-643
WK-643 is a novel Lysine (K) inhibitor potentially used as an antihypertensive drug. It showed high activity in preclinical high blood pressure model. Uses: Potential antihypertensive drug. Synonyms: WK 643; WK643.
WK88-1
WK88-1 inhibits Hsp90, resulting in decreased expression of Hsp90 client proteins and potentially leading to decreased tumor cell growth. Synonyms: WK88-1; WK88 1; WK881. Grades: >98%. CAS No. 958888-32-9. Molecular formula: C28H42N2O6. Mole weight: 502.64.
WK-X-34
WK-X-34 is Inhibitor of P-glycoprotein and BCRP. Synonyms: WKX34; WKX-34; WKX 34; WK-X 34; WK-X34. Grades: 98%. CAS No. 908859-10-9. Molecular formula: C35H37N3O6. Mole weight: 595.70.
WKYMVM
WKYMVm is a selective agonist for the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM) and FPR3 (EC50 = 3 nM) that is expressed on immune cells. WKYMVm induces Ca2+ mobilization and superoxide production in, and chemotaxic migration of, monocytes and neutrophils. Synonyms: Trp-Lys-Tyr-Met-Val-D-Met-NH2; Leukocyte chemoattractant peptide; W-Peptide. CAS No. 187986-17-0. Molecular formula: C41H61N9O7S2. Mole weight: 856.11.
WKYMVM
WKYMVM. Group: Biochemicals. Grades: Purified. CAS No. 187986-11-4. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
WKYMVM 2TFA
WKYMVM 2TFA is a selective agonist of the formyl peptide receptors FPR1, FPR2 (EC50 = 75 pM), and FPR3 (EC50 = 3 nM) and is expressed on immune cells. It induces Ca2+ mobilization and superoxide production, as well as chemotactic migration of monocytes and neutrophils. Synonyms: H-Trp-Lys-Tyr-Met-Val-D-Met-NH2.2TFA; L-tryptophyl-L-lysyl-L-tyrosyl-L-methionyl-L-valyl-D-methioninamide trifluoroacetic acid; (2R,5S,8S,11S,14S,17S)-17-Amino-14-(4-aminobutyl)-11-(4-hydroxybenzyl)-18-(1H-indol-3-yl)-5-isopropyl-2,8-bis[2-(methylsulfanyl)ethyl]-4,7,10,13,16-pentaoxo-3,6,9,12,15-pentaazaoctadecan-1-amide trifluoroacetate; W-Peptide TFA salt; WKYMVm TFA salt. Grades: ≥95%. Molecular formula: C41H61N9O7S2.2C2HF3O2. Mole weight: 1084.16.
WL 47 - dimer
WL 47 - dimer acts as a high affinity caveolin-1 (CAV1) ligand (Kd = 23 nM) to disrupt the formation of caveolin-1 oligomers. It has selectivity for CAV1 over BSA, casein and HEWL. Synonyms: WL 47 - dimer; WL47 - dimer; WL-47 - dimer. Molecular formula: C80H130N24O18S4. Mole weight: 1844.3.
WLBU2
WLBU2 is a synthetic cationic antibacterial peptide that can kill Pseudomonas aeruginosa in human serum. Synonyms: Arg-Arg-Trp-Val-Arg-Arg-Val-Arg-Arg-Trp-Val-Arg-Arg-Val-Val-Arg-Val-Val-Arg-Arg-Trp-Val-Arg-Arg. Grades: >96%. Molecular formula: C151H260N66O25. Mole weight: 3400.15.
WM-1119
WM-1119 is a highly potent, selective inhibitor of lysine acetyltransferase KAT6A with IC50 of 0.25 μM. It is 1,100-fold and 250-fold more active against KAT6A than against KAT5 or KAT7, respectively. Synonyms: 2-Fluoro-N'-(3-fluoro-5-(pyridin-2-yl)benzoyl)benzenesulfonohydrazide. CAS No. 2055397-28-7. Molecular formula: C18H13F2N3O3S. Mole weight: 389.38.
WM-662
WM-662 is a WDR5-MYC interaction inhibitor, with an IC 50 of 18 μM. WM-662 has potential for the research of cancer, aging, and neurodegenerative disorders [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1308257-47-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-154847.
WNK463
WNK463 is a pan-WNK-kinase catalytic activity inhibitor. Synonyms: WNK-463; WNK 463; N-Tert-butyl-3-[1-[5-[5-(trifluoromethyl)-1,3,4-oxadiazol-2-yl]pyridin-2-yl]piperidin-4-yl]imidazole-4-carboxamide. CAS No. 2012607-27-9. Molecular formula: C21H24F3N7O2. Mole weight: 463.46.
WNS Apricot Kernel Shells
WNS Apricot Kernel Shells - Apricot Kernel Shells are granules prepared from crushed apricot shells. The shells have a hard fibrous material ideal as a gentle, natural exfoliate which assists with the removal of dead skin cells. Its grit is a soft abrasive that is extremely durable, angular & multi-faceted. Categories: Apricot kernels.
United States and all of its trading partners..
WNS Walnut Shells
Walnut Shell Powder is prepared from finely crushed walnut shells. The shells have a hard fibrous material ideal as a gentle, natural exfoliant which assists with the removal of dead skin cells. Its grit is a soft abrasive that is extremely durable, angular & multi-faceted. Categories: Juglandaceae; Juglans regia.
United States and all of its trading partners..
Wnt Agonist II, SKL2001 (Wnt Pathway Activator VII, 5-(Furan-2-yl)-N-(3-(1H-imidazol-1-yl)propyl)-1,2-oxazole-3-carboxamide)
A cell-permeable imidazolyl-isoxazolamide that upregulates b-catenin-regulated transcription (CRT; 10-40uM) by disrupting beta-catenin and Axin interaction, thereby preventing b-catenin phosphorylation (Ser33 / Ser37 / Thr41 / Ser45) and proteasomal degradation, without affecting the activities of GSK-3alpha/beta or 18 other kinases (<8.5% inhibition by 10uM SKL2001). Shown to effectively promote osteoblastogenesis in both human and murine mesenchymal cultures (10 to 40uM) as well as suppress MDI- (dexamethasone and insulin) stimulated adipogenesis of murine 3T3-L1 preadipocytes (5 to 30uM). Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
Wnt Antagonist, C59
Cell-permeable. A potent Wnt signaling pathway inhibitor (IC50 = <0.11nM using Wnt-Luc reporter assay). Group: Biochemicals. Alternative Names: 2-(4-(2-Methylpyridin-4-yl)phenyl)-N-4-(pyridin-3-yl)phenyl) Acetamide. Grades: Highly Purified. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Wnt-C59
Wnt-C59 is a potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay. It was shown to arrest stemness and suppress growth of nasopharyngeal carcinoma in mice via Wnt pathway inhibition. Synonyms: 2-(4-(2-methylpyridin-4-yl)phenyl)-N-(4-(pyridin-3-yl)phenyl)acetamide. Grades: >98%. CAS No. 1243243-89-1. Molecular formula: C25H21N3O. Mole weight: 379.45.
Wnt-C59
Highly potent inhibitor of Porcupine (PORCN), a membrane-bound O-acyltransferase (MBOAT) (IC50 = 74 pM). Shown to inhibit Wnt signaling pathways. Blocks progression of mammary tumors in MMTV-WNT1 transgenic mice and downregulates Wnt/ β-catenin target genes. Induces cardiomyocyte differentiation from human iPSCs following culture with CHIR 99021. Cell permeable and orally bioavailable. Group: Biochemicals. Grades: Highly Purified. CAS No. 1243243-89-1. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Wnt-C59
Wnt-C59 (C59) is a highly potent and oral porcupine (PORCN) inhibitor with an IC 50 of 74 pM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: C59. CAS No. 1243243-89-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15659.
Wnt/Hedgehog/Notch Compound Library
A unique collection of 240 Wnt/Hedgehog/Notch signaling targeted compounds for high throughput and high content screening; - Bioactivity and safety confirmed by pre-clinical research and clinical trials; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4300. Categories: Wnt/Hedgehog/Notch Compounds Libraries.
Wnt Inhibitor IWP-2
IWP-2 is an inhibitor of Wnt processing and secretion with IC50 of 27 nM. Uses: Differentiation. Synonyms: IWP 2, IWP-2, IWP2. Grades: 0.98. CAS No. 686770-61-6. Molecular formula: C22H18N4O2S3. Mole weight: 466.592.
WNTinib
WNTinib (APS-8-100-2) is a multi-kinase inhibitor that selectively antagonizes β-catenin (CTNNB1) mutated hepatocellular carcinoma (HCC). WNTinib downregulates oncogenic Wnt signaling by inhibiting KIT/MAPK and downstream EZH2 activation [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: APS-8-100-2. CAS No. 2770091-44-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-160765.
Wnt pathway inhibitor 3
Wnt pathway inhibitor 3 is a potent wnt inhibitor with an IC 50 value of 45 nM. Wnt pathway inhibitor 3 shows antiproliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 663213-98-7. Pack Sizes: 5 mg; 10 mg. Product ID: HY-153750.
Wnt pathway inhibitor 4
Wnt pathway inhibitor 4 (compound 16D) is an anticancer agent that has anti-proliferative activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 663214-57-1. Pack Sizes: 10 mg. Product ID: HY-153753.
Wogonin
Anti-inflammatory. Increases nitroc oxide (NO) production. Inhibits PGE2, cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS; NOS II). Antioxidant. Anti-viral. Shows anti-hepatitis B virus activity. MCP-1 inhibitor. Shows anxiolytic effect through modulation of the GABA(A) receptor complex. Antifungal. Neuroprotective. Anticancer compound. Apoptosis and cell cycle arrest inducer. Sensitizes TNFalpha- and TRAIL-induced apoptosis. Antiangiogenic. NF-kappaB inhibitor. Telomerase activity inhibitor. CDK9 inhibitor. PI3K-AKT pathway modulator. Autophagy inducer. Group: Biochemicals. Alternative Names: WOG, 5,7-Dihydroxy-8-methoxyflavone, BRN 0287152. Grades: Highly Purified. CAS No. 632-85-9. Pack Sizes: 5mg, 25mg. Molecular Formula: C16H12O5. US Biological Life Sciences.
Worldwide
Wogonin
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt, and exhibits anti-inflammatory and anti-tumor effects. Uses: Designed for use in research and industrial production. Product Category: Inhibitors. CAS No. 632-85-9. Molecular formula: C16H12O5. Mole weight: 284.26. Purity: 0.9998. Product ID: ACM632859. Alfa Chemistry ISO 9001:2015 Certified.
Wogonin
Wogonin is a naturally occurring mono-flavonoid, can inhibit the activity of CDK8 and Wnt , and exhibits anti-inflammatory and anti-tumor effects. Uses: Scientific research. Group: Natural products. CAS No. 632-85-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-N0400.
Wogonoside
Wogonoside has shown preclinical anticancer efficacy in various cancer models. Wogonoside has been reported to have anti-inflammatory properties. Uses: Anti-inflammatory. Synonyms: Wogonin 7-O-b-D-glucuronide; Oroxindin. Grades: >98%. CAS No. 51059-44-0. Molecular formula: C22H20O11. Mole weight: 460.39.
Wogonoside
Wogonoside, a flavonoid glycoside isolated from Huangqin, possesses anti-inflammatory effects. Wogonoside induces autophagy in breast cancer cells by regulating MAPK-mTOR pathway [1] [2]. Uses: Scientific research. Group: Natural products. CAS No. 51059-44-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 20 mg. Product ID: HY-N0399.
Wogonoside
Wogonoside. Group: Biochemicals. Alternative Names: Oroxindin; Glychionide B. Grades: Plant Grade. CAS No. 51059-44-0. Pack Sizes: 20mg. Molecular Formula: C22H20O11, Molecular Weight: 460.387999999999. US Biological Life Sciences.
Worldwide
Wolfberry Extract
Wolfberry Extract. Applications: Wolfberry extract can be used in functional food, drinks, health care products and pharmaceuticals. Group: Others. Purity: 10:1, 20:1, 50% Polysaccharide or as required. Appearance: Brown powder. Wolfberry Extract. Cat No: EXTC-158.
Wood Betony Herb Powder(Stachys Officinalis (L.) Trevis)s
Wood Betony Herb Powder(Stachys Officinalis (L.) Trevis)s.
CA, FL & NJ
Woods alloy
Woods alloy. Group: Alloys. Alternative Names: BISMUTH LEAD TIN CADMIUM; ALLOY ACCORDING TO WOOD; WOODS METAL; WOODS METAL; WOODS ALLOY; WOODS ALLOY; Alloy Woods ; WOODS METAL, STICK. CAS No. 76093-98-6. Product ID: bismuth; cadmium; lead; tin. Molecular formula: 546.52. Mole weight: BiCdPdSn. CQHDPRBPWAYYKI-UHFFFAOYSA-N. sticks.
Worenine
Botanical Source: Group: Biochemicals. Alternative Names: 5, 6-Dihydro-14-methylbis[1, 3]benzodioxolo[5, 6-a:5?, 6?-g]quinolizinium(1+), 9CI. 13-Methylpseudocoptisine. Grades: Plant Grade. CAS No. 38763-29-0. Pack Sizes: 10mg, 20mg. US Biological Life Sciences.
Worldwide
Wormwood Extract
Wormwood Extract. Applications: Used for health care products, dietary supplements, herb medecine, mainly for antibacterial. Group: Others. Synonyms: Wormwood Extract; 977032-37-3; Artemisia princes orientalis L. CAS No. 977032-37-3. Purity: 4-10:1 by TLC. Appearance: Yellow brown fine powder. Storage: 2 years under well storage situation and stored away from direct sun light. Source: Leaf. Species: Artemisia princes orientalis L. Wormwood Extract; 977032-37-3; Artemisia princes orientalis L.; plant extract. Pack: 25KG/Drum with double plastic bag of foodstuff inside. Cat No: EXTW-130.
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC50s of 5.8 and 48 nM, respectively. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Wartmannin. Product Category: Inhibitors. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43. Purity: 0.98. Product ID: ACM19545267. Alfa Chemistry ISO 9001:2015 Certified.
Wortmannin
Antibiotic. Potent anti-neutrophil agent with cardioprotective effects. mTOR, DNA-PK, phosphatidylinositol 4-kinases, myosin light chain kinase (MLCK) and mitogen-activated protein kinase (MAPK) inhibitor at high concentrations. Potent cell permeable and selective inhibitor of phosphatidyl-inositol 3-kinase (PI3K). Antitumor compound. Radiosensitizing agent. Adipogenesis inhibitor. Angiogenesis inhibitor. Autophagy inhibitor. DNA repair, receptor-mediated endocytosis and cell proliferation inhibitor. Potentiates the LPS-induced nitric oxide (NO) production from macrophages. Induces in vivo Alzheimer-like hyperphosphorylation in tau. Polo-like kinase family inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 19545-26-7. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C23H24O8. US Biological Life Sciences.
Worldwide
Wortmannin
It is an antibiotic produced by the strain of Pen. wortmanni 989. It has strong antifungal effect. It is a specific covalent inhibitor of phosphoinositide 3-kinases (PI3Ks) and Polo-Like kinase 1 (PLK1). It is a commonly used cell biology reagent that has been used previously in research to inhibit DNA repair, receptor-mediated endocytosis and cell proliferation. Uses: Immunosuppressive agents. Synonyms: Antibiotic SL-2052; (1alpha,11alpha)-11-(Acetyloxy)-1-(methoxymethyl)-2-oxaandrosta-5,8-dieno(6,5,4-bc)furan-3,7,17-trione; (1S,6bR,9aS,11R,11bR)-1-(Methoxymethyl)-9a,11b-dimethyl-3,6,9-trioxo-1,6,6b,7,8,9,9a,10,11,11b-decahydro-3H-furo[4,3,2-de]indeno[4,5-h]isochromen-11-yl acetate. Grades: 98%. CAS No. 19545-26-7. Molecular formula: C23H24O8. Mole weight: 428.43.
Wortmannin
Wortmannin (SL-2052; KY-12420) is a potent, selective and irreversible PI3K inhibitor with an IC 50 of 3 nM. Wortmannin also blocks autophagy formation, and potently inhibits Polo-like kinase 1 (PlK1) and Plk3 with IC 50 s of 5.8 and 48 nM, respectively [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: SL-2052; KY-12420. CAS No. 19545-26-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10197.
Wortmannin-Rapamycin Conjugate
Wortmannin is a potent inhibitor of PI3K enzymes, and rapamycin blocks mTOR. The wortmannin-rapamycin conjugate inhibits the growth of HT-29 colon tumors and A498 renal tumors in mice better than rapamycin alone. Synonyms: Wortmannin-Rapamycin Conjugate; 1067892-47-0; AKOS040755180. Grades: ≥98%. CAS No. 1067892-47-0. Molecular formula: C88H131N3O23. Mole weight: 1598.9.
WP-1034
WP-1034 is a novel Jak-Stat inhibitor, which is active against AML blasts. WP-1034 effectively inhibited proliferation of OCIM2 cells and fresh AML samples. WP-1034 caused cell cycle arrest of OCIM2 cells in sub-Go phase. WP-1034 induced apoptosis of OCIM2 cells and that induction of apoptosis involved cleavage of caspase 3 and the DNA repair enzyme poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP). Synonyms: WP1034; WP 1034; (R,E)-2-cyano-3-(4-nitrophenyl)-N-(1-phenylethyl)acrylamide. CAS No. 857064-42-7. Molecular formula: C18H15N3O3. Mole weight: 321.33.
WP1066
WP1066 is a JAK2 and STAT3 inhibitor. It was shown to inhibit proliferation and induce apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Synonyms: (E)-3-(6-bromopyridin-2-yl)-2-cyano-N-[(1S)-1-phenylethyl]prop-2-enamide. Grades: >98%. CAS No. 857064-38-1. Molecular formula: C17H14BrN3O. Mole weight: 356.223.
WP1066
WP1066 is an inhibitor of JAK2 and STAT3 , and also shows effect on STAT5 and ERK1/2, without affecting JAK1 and JAK3. Uses: Scientific research. Group: Signaling pathways. CAS No. 857064-38-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15312.
A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway. Group: Biochemicals. Grades: Purified. CAS No. 857064-38-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
WP1130 (Degrasyn)
A cell-permeable tyrphostin compound that acts as a partially selective deubiquitinase (DUB) inhibitor and suppresses JAK-Stat signaling pathway. Reported to cause accumulation of polyubiquitinated p53, JAK2 and Bcr-Abl, and reduce c-Myc and MCL-1 protein levels in several tumor cells and downregulate Stat3 and NF-kB activities (IC50 < 1uM in MCL cells) leading to tumor cell apoptosis (IC50 ~1.2uM in Z138 cells). Suggested to modify active site cysteine of DUB and inhibit USP5, UCH-L1, USP9x, USP14, and UCH37 activities (≥80% inhibition at 5uM) without affecting 20S proteasome. Reported to exert stronger antiproliferative and antitumor properties than STAT3 Inhibitor III, WP1066 in xenograft mouse models of CML and melanoma. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.