A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Coumarin suberoylanilide hydroxamic acid. Group: Biochemicals. Alternative Names: N1-Hydroxy-N8-(4-methyl-2-oxo-2H-1-benzopyran-7-yl)octanediamide; Coumarin-SAHA. Grades: Highly Purified. CAS No. 1260635-77-5. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C18H22N2O5. US Biological Life Sciences.
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Coumatetralyl
Coumatetralyl. Group: Biochemicals. Alternative Names: 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthalenyl)-2H-1-benzopyran-2-one; 4-Hydroxy-3-(1,2,3,4-tetrahydro-1-naphthyl)coumarin; 3-(1,2,3,4-Tetrahydro-1-naphthyl)-4-hydroxycoumarin. Grades: Highly Purified. CAS No. 5836-29-3. Pack Sizes: 100mg, 250mg, 500mg, 1g. Molecular Formula: C19H16O3. US Biological Life Sciences.
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Coumermycin a1
Coumermycin A1 is a JAK2 signal activator. Coumermycin A1 inhibits DNA Gyrase which thereby inhibits cell division in bacteria. Coumermycin A1 shows anti-orthopoxvirus activity. Group: Inhibitors. CAS No. 4434-5-3. Molecular formula: C55H59N5O20. Mole weight: 1110.08. Appearance: Solid. Purity: ≥97.0%. Canonical SMILES: OC (C1=CC=C (O[C@@H] ([C@H] (O)[C@H] (OC (C2=CC=C (C)N2)=O)[C@H]3OC)OC3 (C)C)C (C)=C1O4)=C (NC (C5=CNC (C (NC6=C (O)C7=CC=C (O[C@@H] ([C@H] (O)[C@H] (OC (C8=CC=C (C)N8)=O)[C@H]9OC)OC9 (C)C)C (C)=C7OC6=O)=O)=C5C)=O)C4=O. Catalog: ACM4434053.
Coumermycin A1
Coumemycin A1 is found to bind at a second ATP-binding site in the C-terminal domain of Hsp90, IC50 70 μmol/L. It is produced by the strain of Streptomyces rishirensis, Str. spinichromogene and Str. Spinicoumarensis. It has anti-gram positive bacteria, negative bacteria, mycobacterium (weak) activity, cross-resistance with Novobiocin. Uses: Topoisomerase ii inhibitors. Synonyms: coumermycin a1; Coumamycine; Coumamycinum; Cumamicina; Notomycin; Coumamycin; Notomycin A1; Sugordomycin D-1a; Sugordomycin; Antibiotic Bu-620. Grades: >98%. CAS No. 4434-5-3. Molecular formula: C55H59N5O20. Mole weight: 1110.09.
Coumestrol
Coumestrol, a phytoestrogen present in soybean products, exhibits activities against cancers, neurological disorders, and autoimmune diseases. It suppresses proliferation of ES2 cells with an IC 50 of 50 μM. Uses: Scientific research. Group: Natural products. CAS No. 479-13-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-N2335.
Coumestrol
Coumestrol. Group: Biochemicals. Alternative Names: 3,9-Dihydroxy-6H-benzofuro[3,2-c]-[1]benzopyran-6-one; 2-(2,4-Dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic acid δ-lactone. Grades: Highly Purified. CAS No. 479-13-0. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C15H8O5. US Biological Life Sciences.
This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution. Group: Biochemicals. Alternative Names: 3,9-Dihydroxy-6H-benzofuro[3,2-c]-[1]benzopyran-6-one. Grades: Highly Purified. Pack Sizes: 5mg. US Biological Life Sciences.
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Covalent Inhibitor Library
A unique collection of 941 covalent Inhibitors and other molecules with common warheads like chloroacetyl?2-Chloropropionyl?Acryloyl?sulfonyl fluoride, alkyne?acrylamide, ketocarbonyl?disulfide bond, etc. - Structurally diverse with some covalent inhibitors approved by the FDA- Detailed compound information with structure, target, IC50, and biological activity description- NMR and HPLC/LCMS validated to ensure high purity. Uses: Scientific use. Product Category: L9410. Categories: Covalent Inhibitor Libraries.
Covalent Natural Product Library
Detialed biological information and pharmacological information of the products, providing theoretical direction and research basis for screening. - Clear source: a selection of known active natural products from animals, plants and microorganisms; specific to plant species, and labeled with accurate English and Latin names that facilitates later verification in your research. - Comprehensive information: Detailed descriptions from compound structure to solubility, from signaling pathways and targets to biological activity information. - Cost-effective: eliminates expensive natural products with poor drug-forming properties, allowing you to get more high-quality natural products at a lower cost. - Highly customizable with free combination according to natural product source, natural product category, research area, drug market status, etc. Uses: Scientific use. Product Category: L6150. Categories: Covalent Natural Product Libraries.
CovidyteTM ED450
CovidyteTM ED450, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) at the N-terminus and Edans (donor) at the C-terminus, respectively, and the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When it is hydrolyzed by the coronavirus protease, the fluorescence of the Edans fragment is significantly enhanced because its fluorescence is no longer quenched by Dabcyl. Edans fluorescence intensity can effectively monitor the activity of coronavirus protease. It is a handy tool for screening coronavirus protease inhibitors. (excitation at 336, emission at 455 nm). Synonyms: EDANS-Val-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys(DABCYL)-Met-OH. Molecular formula: C82H125N23O22S2. Mole weight: 1849.14.
CovidyteTM EN450
CovidyteTM EN450, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Dabcyl (quencher) at the N-terminus and Edans (donor) at the C-terminus, respectively, and the fluorescence of Edans is effectively quenched by Dabcyl when the peptide is intact. When it is hydrolyzed by the coronavirus protease, the fluorescence of the Edans fragment is significantly enhanced because its fluorescence is no longer quenched by Dabcyl. Edans fluorescence intensity can effectively monitor the activity of coronavirus protease. It is a handy tool for screening coronavirus protease inhibitors. (excitation at 350, emission at 460 nm). Synonyms: H-Lys(DABCYL)-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-EDANS. Molecular formula: C95H141N25O24S2. Mole weight: 2081.42.
CovidyteTM IF670
CovidyteTM IF670, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide QuencherTM 5 (TQ5) as a quencher at the N-terminal and iFluorTM 670 as a fluorescent donor at the C-terminal, respectively. When the peptide is intact, the fluorescence of iFluorTM 670 is effectively quenched by TQ5. When the peptide is hydrolyzed by the coronavirus proteases, the fluorescence of the iFluorTM 670 fragment is no longer quenched by TQ5, and the fluorescence is significantly enhanced. The fluorescence intensity of iFluorTM 670 can be used to effectively monitor the activity of coronavirus proteases. It is a powerful high-throughput screening tool for searching inhibitors of coronavirus protease. Compared to commonly used EDANS substrates, such as CovidyteTM ED450, the iFluorTM 670 substrate has stronger and longer fluorescence and is less disturbed by colored compounds that often cause false positive hits. (excitation at 656, emission at 670 nm). Synonyms: H-Cys(iFluor 647)-Val-Asn-Ser-Thr-Leu-Gln-Ser-Gly-Leu-Arg-Lys(TQ5)-Met-OH. Molecular formula: C58H105N19O19S2 + dye. Mole weight: 3068.
CovidyteTM TF670
CovidyteTM TF670, a peptide substrate, can be cleaved by coronavirus proteases. The dark-FRET peptide contains Tide QuencherTM 5 (TQ5) as a quencher at the N-terminal and Tide FluorTM 5 (TF5) as a fluorescence donor at the C-terminal, respectively. When the peptide is intact, the fluorescence of TF5 is effectively quenched by TQ5. When the peptide is hydrolyzed by the coronavirus proteases, the fluorescence of the TF5 fragment is no longer quenched by TQ5, and the fluorescence is significantly enhanced. The fluorescence intensity of TF5 can be used to effectively monitor the activity of coronavirus proteases. It is a powerful high-throughput screening tool for searching inhibitors of coronavirus protease. TQ5-TF5 pair has proved to be an extremely effective FRET pair for the development of FRET protease substrates. Compared to commonly used EDANS substrates, such as CovidyteTM EN450, the TF670 substrate has stronger, longer fluorescence and is less disturbed by colored compounds that often cause false positive hits. (excitation at 640, emission at 680 nm). Synonyms: H-Lys(TQ5)-Thr-Ser-Ala-Val-Leu-Gln-Ser-Gly-Phe-Arg-Lys-Met-Glu-Cys(TF5)-OH. Molecular formula: C71H121N21O22S2 + dye. Mole weight: 3620.
Coviracil (Emtricitabine)
A reverse transcriptase inhibitor. It is an effective antiviral agent against HIV, HBV, and other viruses replicating in a similar manner. A nucleoside analog structurally related to Lamivudine. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-1-[(2R,5S)-2-hydroxymethyl)-1,3-oxathiolan-5-yl]-2-(1H-pyrimidinone; (-)-2,3-Dideoxy-5-fluoro-3-thiacytidine; (-)-2-Deoxy-5-fluoro-3-thiacytidine; BW 1592; BW 524W91; Coviracil; Emtriva; (-)-FTC. Grades: Highly Purified. CAS No. 143491-57-0,143491-54-7. Pack Sizes: 1g, 5g, 10g. Molecular Formula: C?H??FN?O?S, Molecular Weight: 247.25. US Biological Life Sciences.
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Cowaxanthone B
Cowaxanthone B. Group: Biochemicals. Alternative Names: 1,3-Dihydroxy-6,7-dimethoxy-2,8-diprenylxanthone. Grades: Plant Grade. CAS No. 212842-64-3. Pack Sizes: 10mg. Molecular Formula: C25H28O6, Molecular Weight: 424.486. US Biological Life Sciences.
Worldwide
Cowaxanthone B
Cowaxanthone B is a xanthone isolated from the fruits of Garcinia cowa. Cowaxanthone B has weak antibacterial activity. Group: Inhibitors. CAS No. 212842-64-3. Molecular formula: C25H28O6. Mole weight: 424.49. Canonical SMILES: C/C (C)=C\CC1=C (OC)C (OC)=CC (OC2=CC (O)=C (C/C=C (C)/C)C (O)=C23)=C1C3=O. Catalog: ACM212842643.
COX 2 Downstream Primer, 724bp amplimer (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2). Group: Molecular Biology. Pack Sizes: 50uM. US Biological Life Sciences.
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COX-2-IN-1
A potent and slective COX-2 inhibitor(IC50= 3.9 μM). Synonyms: 1-(4-Sulfamylphenyl)-3-trifluoromethyl-5-(7-chloroindol-3-yl)-2-pyrazoline; 4-[3-(7-chloro-1H-indol-3-yl)-5-(trifluoromethyl)-3,4-dihydropyrazol-2-yl]benzenesulfonamide. CAS No. 787623-48-7. Molecular formula: C18H14ClF3N4O2S. Mole weight: 442.84.
COX-2-IN-18
COX-2-IN-18 (Compound 3) is a potent inhibitor of COX-2. COX-2-IN-18 possesses good COX-2 inhibitory activity ( IC 50 = 0.775 μM) compared to the reference agent, Celecoxib ( IC 50 = 0.153 μM). COX-2-IN-18 has the potential for the research of cancer diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1038061-96-9. Pack Sizes: 5 mg. Product ID: HY-147794.
COX-2-IN-2
COX2-IN-1 is a selective and inducible COX2 inhibitor (IC50= 0.24 μM) with anti-inflammatory and analgesic activities. Synonyms: 1-(4-fluorophenyl)-5-(4-methylsulfonylphenyl)pyrazole-3-carbonitrile. CAS No. 134729-13-8. Molecular formula: C17H12FN3O2S. Mole weight: 341.36.
COX-2 Inhibitor I
An inhibitor of COX-2. Synonyms: Methyl [5-methylsulfonyl-1-(4-chlorobenzyl)-1H-2-indolyl]carboxylate; LM-1685; LM 1685; LM1685. CAS No. 416901-58-1. Molecular formula: C18H16ClNO4S. Mole weight: 377.8.
COX-2 Inhibitor I - CAS 416901-58-1
The COX-2 Inhibitor I, also referenced under CAS 416901-58-1, controls the biological activity of COX-2. This small molecule/inhibitor is primarily used for Cell Signaling applications. Uses: For analytical and research use. Group: Fluorescence/luminescence spectroscopy. CAS No. 416901-58-1. Pack Sizes: 5MG. Mole Weight: 377.84. Catalog: AP416901581. Assay: ≥97% (HPLC).
COX-2 Inhibitor II
A selective inhibitor of COX-2. Synonyms: SC-791; IN1371; 181696-33-3; 4-[(5-Difluoromethyl-3-phenyl)-4-isoxazolyl]benzenesulfonamide; SCHEMBL214781. CAS No. 181696-33-3. Molecular formula: C16H12F2N2O3S. Mole weight: 350.34.
COX-2 Inhibitor V, FK3311
COX-2 Inhibitor V, FK3311 is a selective Cox-2 inhibitor and NSAID. Group: Biochemicals. Grades: Highly Purified. CAS No. 116686-15-8. Pack Sizes: 5mg, 10mg. Molecular Formula: C15H13F2NO4S, Molecular Weight: 341.33. US Biological Life Sciences.
COX 2 Upstream Primer, 724bp amplimer (Cyclooxygenase 2, PGHS 2, Prostaglandin Endoperoxide Synthase 2, PHS 2). Group: Molecular Biology. Pack Sizes: 50uM. US Biological Life Sciences.
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COX/5-LO-IN-1
A dual inhibitor of cylooxygenase and 5-lipoxygenase. Synonyms: Urea, N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propyn-1-yl]-N-hydroxy-; 1-[4-[5-[(4-fluorophenyl)methyl]thiophen-2-yl]but-3-yn-2-yl]-1-hydroxyurea. CAS No. 154355-75-6. Molecular formula: C16H15FN2O2S. Mole weight: 318.37.
CP-060 is a novel type of Ca(2+) antagonist possessing both Ca(2+) overload inhibition, with antioxidant and cardioprotective activities. Synonyms: CP-060; CP060; CP 060; 3-[3-[2-(1,3-benzodioxol-5-yloxy)ethyl-methylamino]propyl]-2-(3,5-ditert-butyl-4-hydroxyphenyl)-1,3-thiazolidin-4-one. CAS No. 180090-15-7. Molecular formula: C30H42N2O5S. Mole weight: 542.73.
CP-10
CP-10 is a PROTAC connected by ligands for Cereblon and CDK , with highly selective, specific, and remarkable CDK6 degradation ( DC 50 =2.1 nM). It inhibits proliferation of several haematopoietic cancer cells with impressive potency including multiple myeloma, and can still degrades mutated and overexpressed CDK6 [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2366268-80-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 50 mg. Product ID: HY-125835.
CP-100263 Dihydrochloride Hydrate
CP-100263 is an NK-1 neurokinin receptor antagonist as testosterone replacement therapy. Group: Biochemicals. Alternative Names: (2R,3R)-N-[(2-methoxyphenyl)methyl]-2-phenyl-3-piperidinamine Dihydrochloride Hydrate; (2R-cis)-N-[(2-methoxyphenyl)methyl]-2-phenyl-3-piperidinamine Dihydrochloride Hydrate; (-)-CP 99994 Dihydrochloride Hydrate; CP 100263 Dihydrochloride Hydrate. Grades: Highly Purified. CAS No. 872726-33-5. Pack Sizes: 10mg. US Biological Life Sciences.
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CP 100356
CP 100356 is a high affinity P-glycoprotein inhibitor.Ki value is 58 nM for mouse Pgp1a and 94nMfor Pgp1b isoforms. It can Inhibit calcein-AM uptake in MDR1-transfected MDCKII cells with IC50 value of 0.5 μM and prazosin transport in BCRP-transfected MDCKII cells with IC50 value of 1.5 μM. Preclinical development for Cancer in USA was discontinued. Uses: Cancer. Synonyms: CP 100356; CP100356; CP-100356; 4-(3,4-dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-(2-(3,4-dimethoxyphenyl)ethyl)-6,7-dimethoxy-2-Quinazolinamine; 142715-48-8(hydrochloride). Grades: >98 %. CAS No. 142716-85-6. Molecular formula: C31H36N4O6. Mole weight: 560.64.
CP 100356 hydrochloride
The hydrochloride salt form of CP-100356, which has been found to be an inhibitor of MDR1 (P-Gp) and show inactive in inhibiting multidrug resistance-associated protein 2 (MPR2). Synonyms: CP 100356 hydrochloride; CP100356 hydrochloride; CP-100356 hydrochloride; 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-2[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine hydrochloride. Grades: ≥98% by HPLC. CAS No. 142715-48-8. Molecular formula: C31H36N4O6.HCl. Mole weight: 597.10.
CP-100356 Hydrochloride
CP-100356 is a specific inhibitor of MDR1 (P-Gp), the protypical ABC transporter. CP-100356 also inhibits prazosin transport in human breast cancer resistance protein (BCRP)-transfected MDCKII cells, suggesting that it acts as a dual inhibitor. CP-100356 does not inhibit multidrug resistance-associated protein 2 (MPR2 IC50 >15 mM). Group: Biochemicals. Alternative Names: 4-(3,4-Dihydro-6,7-dimethoxy-2(1H)-isoquinolinyl)-N-[2-(3,4-dimethoxyphenyl)ethyl]-6,7-dimethoxy-2-quinazolinamine Monohydrochloride. Grades: Highly Purified. CAS No. 142715-48-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
CP-100829
CP-100829, an indole derivative, could probably be useful in some biological studies. Synonyms: CP-100829; CP100829; CP 100829; UNII-X7Y3B8B649. X7Y3B8B649; 1H-Indole-1-carboxamide, 6-chloro-3-((4-chloro-2-thienyl)carbonyl)-5-fluoro-2,3-dihydro-2-oxo-; 1H-Indole-1-carboxamide, 6-chloro-3-((4-chloro-2-thienyl)hydroxymethylene)-5-fluoro-2,3-dihydro-2-oxo-, (Z)-. Grades: 98%. CAS No. 172618-05-2. Molecular formula: C14H7Cl2FN2O3S. Mole weight: 373.18.
CP 101606
CP 101606 is a potent and selective NR2B antagonist of N-Methyl-D-Aspartate (NMDA) glutamate receptors. It decreases pentylenetetrazol-induced seizures. Synonyms: CP-101606; CP 101606; CP101606; Traxoprodil; 1-((1S,2S)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl)-4-phenylpiperidin-4-ol. Grades: 99%. CAS No. 134234-12-1. Molecular formula: C20H25NO3. Mole weight: 327.42.