A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Crenolanib is a potent and selective inhibitor of wild-type and mutant isoforms of the class III receptor tyrosine kinases FLT3 and PDGFRα/β with K d s of 0.74 nM and 2.1 nM/3.2 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CP-868596. CAS No. 670220-88-9. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-13223.
Crenolanib
Crenolanib is an orally bioavailable small molecule, targeting the platelet-derived growth factor receptor (PDGFR), with potential antineoplastic activity. Crenolanib binds to and inhibits PDGFR, which may result in the inhibition of PDGFR-related signal transduction pathways, and, so, the inhibition of tumor angiogenesis and tumor cell proliferation. PDGFR, up-regulated in many tumor cell types, is a receptor tyrosine kinase essential to cell migration and the development of the microvasculature. Synonyms: CP 868596; CP868596; CP-868596; ARO 002; RO-002; RO002; Crenolanib. CAS No. 670220-88-9. Molecular formula: C26H29N5O2. Mole weight: 443.551.
Crenolanib
Crenolanib is a tyrosine kinase inhibitor that acts by specifically inhibiting the receptor tyrosine kinases PDGFRα and PDGFR β. Crenolanib inhibits the activity of PDGFRα D842V kinase and prevented the phosphorylation of wild type PDGFRα. Crenolanib possesses potential antineoplastic activity. Crenolanib is believed to suppress PDGFR-related signal transduction pathways leading to the inhibition of tumor angiogenesis and tumor cell proliferation. Group: Biochemicals. Alternative Names: 1-[2-[5-[(3-Methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine; ARO 002; CP 868596; [1-[2-[5-(3-Methyloxetan-3-ylmethoxy)benzimidazol-1-yl]quinolin-8-yl]piperidin-4-yl]amine. Grades: Highly Purified. CAS No. 670220-88-9. Pack Sizes: 5mg. US Biological Life Sciences.
Creosol (2-Methoxy-4-methylphenol) is an endogenous metabolite that acts as an important chemical intermediate and potential biofuel mainly derived from lignocellulosic biomass. Creosol is blood brain barrier penetrable [1] [2] [3]. Uses: Scientific research. Group: Natural products. Alternative Names: 2-Methoxy-4-methylphenol. CAS No. 93-51-6. Pack Sizes: 10 mM * 1 mL; 500 mg. Product ID: HY-W040971.
Creosote
Creosote is the name used for a variety of products: wood creosote, coal tar creosote, coal tar, coal tar pitch, and coal tar pitch volatiles. These products are mixtures of many chemicals created by burning of beech and other woods, coal, or from the resin of the creosote bush. Uses: Creosote is used in construction (roofing), railroad and utilities industries, and for wood treatment and waterproofing. Synonyms: BEECHWOOD CREOSOTE; CREOSOTE; CREOSOTE COAL TAR; COAL TAR CREOSOTE; CREOSOTE FROM BEECHWOOD; Creosote(woodtarfraction); Creosote,woodtarfraction; CREOSOTE-IMPREGNATEDWASTEMATERIALS. CAS No. 8021-39-4. Molecular formula: C7H8O2. Mole weight: 124.13722.
Creosote from beechwood tar
25g Pack Size. Group: Aroma Chemicals, Biochemicals, Flavours and Fragrance Materials. Formula: C7H8O2. CAS No. 8021-39-4. Prepack ID 40878500-25g. Molecular Weight 124.13. See USA prepack pricing.
Creosote Oil
Creosote Oil. We stock inventory in warehouses throughout the United States, allowing us to serve customers in all regions in a timely and cost effective manner.
California
Cresol
Cresol. Group: Biochemicals. Alternative Names: Methylphenol tricresol. Grades: Highly Purified. CAS No. 1319-77-3. Pack Sizes: 5kg. US Biological Life Sciences.
Worldwide
Cresol ≥80%
Cresol ≥80%. Group: Biochemicals. Grades: Reagent Grade. CAS No. 1319-77-3. Pack Sizes: 1Kg, 4Kg, 10Kg. US Biological Life Sciences.
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Cresol Para Pure
Cresol Para Pure. CAS No. 106-44-5. FEMA No. 2337. Kosher: Y. VIGON Item # 502603. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Cresol red
Cresol red. Group: Biochemicals. Grades: Reagent Grade. Pack Sizes: 25g, 100g, 250g. US Biological Life Sciences.
Worldwide
Cresol Red
25g Pack Size. Group: Stains & Indicators. Formula: C21H18O5S. CAS No. 1733-12-6. Prepack ID 32608392-25g. Molecular Weight 382.43. See USA prepack pricing.
Cresol Red, Laboratory Grade, 1 g
Storage Code: Green; general chemical storage. Group: chem-category ph-indicators. Alternative Names: o-cresolsulfonephthalein. Grades: chem-grade laboratory. Product ID: 856053. -- SOLD FOR EDUCATIONAL USE ONLY --
Cresol red sodium salt
Cresol red sodium salt. Group: Biochemicals. Grades: Reagent Grade. CAS No. 62625-29-0. Pack Sizes: 25g, 100g, 1Kg. US Biological Life Sciences.
Worldwide
Cresol Red sodium salt
25g Pack Size. Group: Stains & Indicators. Formula: C21H17O5SNa. CAS No. 62625-29-0. Prepack ID 21771676-25g. Molecular Weight 404.41. See USA prepack pricing.
Cresyl Acetate Para
Cresyl Acetate Para (Para Methyl Phenyl Acetate). CAS No. 140-39-6. FEMA No. 3073. Kosher: Y. VIGON Item # 500765. Categories: Speciality Ingrdients Suppliers, Flavors, Fragrances, Perfumers.
America & Internationally
Cresyl blue,brilliant
Cresyl blue,brilliant. Uses: Designed for use in research and industrial production. Additional or Alternative Names: BRILLIANT CRESYL BLUE ALD;BRILLIANT CRESYL BLUE ZINC CHLORIDE DOUBLE SALT;BRILLIANT BLUE C;CI NO 51010;CRESYL BLUE;CRESYL BLUE BBS;CRESYL BLUE, BRILLIANT;3-amino-7-(diethylamino)-2-methylphenoxazin-5-ium tetrachlorozincate (2:1). Product Category: Heterocyclic Organic Compound. CAS No. 51716-96-2. Molecular formula: C34H40Cl4N6O2Zn. Mole weight: 771.92. Density: 0.808 g/mL at20 °C. Product ID: ACM51716962. Alfa Chemistry ISO 9001:2015 Certified.
Cresyl diphenyl phosphate
Cresyl diphenyl phosphate is a phosphorus flame retardant additive. Group: Biochemicals. Grades: Highly Purified. CAS No. 26444-49-5. Pack Sizes: 1ml, 5ml. Molecular Formula: C20H21O4P, Molecular Weight: 356.35. US Biological Life Sciences.
Cresyl violet. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 6625-37-2, AGN-PC-00KY07, CHEMBL260946, NSC51526, NSC-51526, [9-(dimethylamino)benzo[a]phenoxazin-5-ylidene]azanium;chloride. Product Category: Heterocyclic Organic Compound. CAS No. 6625-37-2. Molecular formula: C18H16N3OCl. Mole weight: 325.8. Purity: 0.96. IUPACName: [9-(dimethylamino)benzo[a]phenoxazin-5-ylidene]azanium;chloride. Canonical SMILES: CN(C)C1=CC2=C(C=C1)N=C3C4=CC=CC=C4C(=[NH2+])C=C3O2.[Cl-]. Density: 1.29g/cm³. Product ID: ACM6625372. Alfa Chemistry ISO 9001:2015 Certified.
Cresyl Violet acetate
Cresyl Violet acetate is a dye, which can be used to stain neurons. Uses: Scientific research. Group: Fluorescent dye. CAS No. 10510-54-0. Pack Sizes: 100 mg. Product ID: HY-101888.
Cresyl Violet acetate
1g Pack Size. Group: Analytical Reagents, Biochemicals, Diagnostic Raw Materials, Stains & Indicators. Formula: C18H15N3O3. CAS No. 10510-54-0. Prepack ID 90022819-1g. Molecular Weight 321.33. See USA prepack pricing.
Cresyl Violet Acetate
Cresyl Violet Acetate. Group: Biochemicals. Alternative Names: Cresyl Fast Violet; 9-Amino-5-imino-5H-benzo(a)phenoxazine acetate salt; CI 5118; Purity Limit≥ 65.% (Dye content)Molecular FormulaC18H15N3O3Molec ular Weight321.34CAS No151-54-MDL NoMFCD13151AppearanceD ark green to almost black powderStorage TempStore at RT. Grades: Highly Purified. CAS No. 10510-54-0. Pack Sizes: 10g, 25g, 50g, 100g. US Biological Life Sciences.
CRF (6-33) has been found to be a CRFBP inhibitor peptide and could probably suppress body weight gain. Synonyms: Corticotropin-Releasing Factor (6-33). Grade: >98%. CAS No. 120066-38-8. Molecular formula: C141H231N41O43S. Mole weight: 3220.68.
CRF (6-33) acetate
CRF (6-33) acetate has been found to be a corticotropin-releasing factor binding protein (CRFBP) inhibitor peptide and could probably suppress body weight gain. Synonyms: H-Ile-Ser-Leu-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-Met-Ala-Arg-Ala-Glu-Gln-Leu-Ala-Gln-Gln-Ala-His-Ser-OH.CH3CO2H; L-isoleucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-threonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-alpha-glutamyl-L-valyl-L-leucyl-L-alpha-glutamyl-L-methionyl-L-alanyl-L-arginyl-L-alanyl-L-alpha-glutamyl-L-glutaminyl-L-leucyl-L-alanyl-L-glutaminyl-L-glutaminyl-L-alanyl-L-histidyl-L-serine acetate; 6-33-Human ACTH-releasing factor acetate; Rat corticotropin-releasing factor(6-33) acetate. Grade: ≥95%. Molecular formula: C143H235N41O45S. Mole weight: 3280.76.
CRF, bovine
CRF, bovine is an effective agonist of CRF (Corticotropin-releasing factor) receptor. Synonyms: Corticotropin Releasing Factor bovine; H-Ser-Gln-Glu-D-Pro-D-Pro-Ile-Ser-Leu-Asp-Leu-aThr-Phe-His-Leu-Leu-Arg-Glu-Val-Leu-Glu-DL-Met-Thr-Lys-D-Ala-D-Asp-D-Gln-D-Leu-D-Ala-D-Gln-D-Gln-D-Ala-D-His-D-Asn-D-Asn-D-Arg-D-Lys-D-Leu-D-Leu-D-Asp-aIle-D-Ala-NH2; L-seryl-L-glutaminyl-L-alpha-glutamyl-D-prolyl-D-prolyl-L-isoleucyl-L-seryl-L-leucyl-L-alpha-aspartyl-L-leucyl-L-allothreonyl-L-phenylalanyl-L-histidyl-L-leucyl-L-leucyl-L-arginyl-L-alpha-glutamyl-L-valyl-L-leucyl-L-alpha-glutamyl-DL-methionyl-L-threonyl-L-lysyl-D-alanyl-D-alpha-aspartyl-D-glutaminyl-D-leucyl-D-alanyl-D-glutaminyl-D-glutaminyl-D-alanyl-D-histidyl-D-asparagyl-D-asparagyl-D-arginyl-D-lysyl-D-leucyl-D-leucyl-D-alpha-aspartyl-L-alloisoleucyl-D-alaninamide. Grade: 95%. CAS No. 92307-52-3. Molecular formula: C206H340N60O63S. Mole weight: 4697.33.
CRF, bovine TFA
CRF, bovine TFA is an effective agonist of CRF (Corticotropin-releasing factor) receptor. Synonyms: Corticotropin Releasing Factor bovine (TFA); CRF Bovine Trifluoroacetate. Grade: >98%. Molecular formula: C206H340N60O63S.C2HF3O2. Mole weight: 4811.36.
c(RGDfK)
Cyclo (-RGDfK) is a potent and selective αvβ3 integrin inhibitor. Grade: 98%. CAS No. 161552-03-0. Molecular formula: C27H41N9O7. Mole weight: 603.67.
cRhodamine B octadecyl ester perchlorate
cRhodamine B octadecyl ester perchlorate. Group: Biochemicals. Grades: Highly Purified. CAS No. 142179-00-8. Pack Sizes: 2mg, 5mg, 10mg, 25mg, 50mg. Molecular Formula: C46H67N2O3·ClO4. US Biological Life Sciences.
Worldwide
Crimson glory rose resinoid
Crimson glory rose resinoid. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Crimson glory rose resinoid;Cyclopentolate hydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 5870-29-1. Molecular formula: C17H25NO3.HCl. Mole weight: 327.85. Density: g/cm³. Product ID: ACM5870291. Alfa Chemistry ISO 9001:2015 Certified.
Crinecerfont hydrochloride
Crinecerfont (SSR-125543) hydrochloride is a potent, orally active, non-peptide CRF1 receptor antagonist. Crinecerfont can be used for Classic congenital adrenal hyperplasia (CAH) research [1]. Crinecerfont (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: SSR-125543 hydrochloride. CAS No. 321839-75-2. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-106203A.
Crinipellin A
It is produced by the strain of Crinipellis stipitaria. It has anti-gram-positive bacteria and Aldrin ascites carcinoma activity. Synonyms: (1R,3R,6S,8R,9S,11R,12R,13R)-8-hydroxy-7a,9a-dimethyl-3-methylidene-7-(propan-2-yl)hexahydro-1aH,5H-pentaleno[6a',1':5,6]pentaleno[1,6a-b]oxirene-2,9(3H,9aH)-dione. CAS No. 97294-60-5. Molecular formula: C20H26O4. Mole weight: 330.42.
Crinipellin B
It is produced by the strain of Crinipellis stipitaria. It has anti-gram-positive bacteria and Aldrin ascites carcinoma activity. Synonyms: (1aS,3aR,4aS,7R,7aR,9R,9aR,9bR)-9-hydroxy-7-isopropyl-7a,9a-dimethyl-3-methyleneoctahydro-3H,8H-pentaleno[6a',1':5,6]pentaleno[1,6a-b]oxirene-2,8(1aH)-dione. CAS No. 97294-61-6. Molecular formula: C20H26O4. Mole weight: 330.42.
cRIPGBM
cRIPGBM is a proapoptotic derivative of RIPGBM. It acts as a cell type-selective inducer of apoptosis in GBM cancer stem cells (CSCs) by binding to receptor-interacting protein kinase 2 (RIPK2), with an EC50 of 68 nM in GBM-1 cells. CAS No. 2361988-76-1. Molecular formula: C26H20FN2O2+. Mole weight: 411.45.
Cripto, FRL1, Cryptic Family 1 (CFC1) Recombinant, Human, Unstained Protein Molecular Weight Marker
Cripto, FRL1, Cryptic Family 1 (CFC1) Recombinant, Human, Unstained Protein Molecular Weight Marker. Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 15ul. US Biological Life Sciences.
Worldwide
crisaborole
Crisaborole is a novel PDE-4 inhibitor used as a nonsteroidal topical medication for the treatment of mild-to-moderate atopic dermatitis (eczema). Crisaborole selectively inhibits PDE-4B which mainly leads to inflammation. Tumor necrosis factor alpha (TNFα), interleukin-12 (IL-12), IL-23 and other cytokines are also suppressed while crisaborole functioning. Uses: The treatment of mild-to-moderate atopic dermatitis (eczema). Synonyms: AN2728; AN-2728; AN 2728; Crisaborole; Eucrisa; 4-((1-Hydroxy-1,3-dihydrobenzo[c][1,2]oxaborol-5-yl)oxy)benzonitrile. Grade: 99%. CAS No. 906673-24-3. Molecular formula: C14H10BNO3. Mole weight: 251.048.
Crisaborole
Crisaborole. Alternative Names: 4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrileAN 2728;AN2728, Crisaborole;Crisaborole (AN2728);AN 2728;AN2728/AN-2728;4-((1-Hydroxy-1,3-dihydrobenzo-[c][1,2]oxaborol-5-yl)oxy)benzonitrile;4-[(1,3-Dihydro-1-hydroxy-2,1-benzoxaborol-5-yl)oxy]benzonitrile. CAS No. 906673-24-3. Product ID: API906673243. Molecular formula: C14H10BNO3. EINECS: 250-635-4. SMILES: B1(C2=C(CO1)C=C(C=C2)OC3=CC=C(C=C3)C#N)O. Appearance: White to beige powder. Standard: Facility GMP. Category: Nonsteroidal Anti-inflammatory (NSAID) APIs.
Crisaborole
Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC 50 of 0.49 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AN-2728; PF-06930164. CAS No. 906673-24-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-10978.
Crisaborole Impurity 35. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,4-dibromo-5-methylphenol. CAS No. 13321-76-1. Molecular formula: C7H6Br2O. Mole weight: 265.93. Catalog: APB13321761.
Crisaborole Impurity 36
Crisaborole Impurity 36. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 2,4-dibromo-3-methylphenol. CAS No. 13321-75-0. Molecular formula: C7H6Br2O. Mole weight: 265.93. Catalog: APB13321750.
Crisaborole M-hydroxybenzaldehyde
Crisaborole M-hydroxybenzaldehyde. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: 3-hydroxybenzaldehyde. CAS No. 100-83-4. Molecular formula: C7H6O2. Mole weight: 122.12. Catalog: APB100834.
Crisaborole (Standard)
Crisaborole (Standard) is the analytical standard of Crisaborole. This product is intended for research and analytical applications. Crisaborole (AN-2728) is a potent inhibitor of PDE4 and cytokine release; inhibit PDE4 with an IC 50 of 0.49 μM. Uses: Scientific research. Group: Signaling pathways. CAS No. 906673-24-3. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10978R.
Crisamicin A
It is produced by the strain of Micromonospora purpureochromogenes subsp. lalotolerans. It only has activity against gram-positive bacteria. The activity of samicin C is stronger than Crisamicin A. Synonyms: (3aS)-5β,5'β-Dimethyl-10,10'-dihydroxy-3,3',3aβ,3'aβ,5,5',6,6',11,11',11bβ,11'bβ-dodecahydro-8,8'-bi[2H-furo[3,2-b]naphtho[2,3-d]pyran]-2,2',6,6',11,11'-hexaone; (3aS,3'aS,5S,5'S,11bS,11'bS)-3,3',3a,3'a,5,5',11b,11'b-Octahydro-10,10'-dihydroxy-5,5'-dimethyl-8,8'-bi[2H-furo[3,2-b]naphtho[2,3-d]pyran]-2,2',6,6',11,11'-hexone; CRS-A; (8,8'-Bi-2H-furo(3,2-b)naphtho(2,3-d)pyran)-2,2',6,6'11,11'-hexone,3,3',3a,3'a,5,5',11b,11'b-octahydro-10,10'-dihydroxy-5,5'-dimethyl-, (3aS-(3aalpha,5alpha,8(3aR*,5R*,11bR*),11balpha))-. CAS No. 95828-47-0. Molecular formula: C32H22O12. Mole weight: 598.51.
Crisamicin C
It is produced by the strain of Micromonospora purpureochromogenes subsp. lalotolerans. It only has activity against gram-positive bacteria. The activity of samicin C is stronger than Crisamicin A. Synonyms: CRS-C. CAS No. 100630-79-3. Molecular formula: C32H22O13. Mole weight: 614.51.
Crisdesalazine
Crisdesalazine is a microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor potentially for the treatment of Alzheimer's type dementia, Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS), Arthritis, Depression, Diabetes and Pancreatitis. Synonyms: AAD-2004; Benzoic acid, 2-hydroxy-5-((2-(4-(trifluoromethyl)phenyl)ethyl)amino)-. CAS No. 927685-43-6. Molecular formula: C16H14F3NO3. Mole weight: 325.28.
Crisdesalazine
Crisdesalazine (AAD-2004) is an anti-inflammatory agent that simultaneously blocks inflammation mediated by free radicals and prostaglandin E2 (PGE2). Crisdesalazine (AAD-2004) can be used to study neurodegeneration in amyotrophic lateral sclerosis (ALS) and other neurodegenerative diseases [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AAD-2004. CAS No. 927685-43-6. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-105005.
Crisnatol
Crisnatol (BWA770U) is an orally active and anticancer agent, and a member of the arylmethylaminopropanediol class of DNA intercalators. Crisnatol shows in vitro cytotoxicity against human breast cancer cells, but not normal human skin fibroblasts. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-((6-chrysenylmethyl)amino)-2-methyl-1,3-propanediol; Crisnatol [INN]; UNII-2J71UR51UE; 1,3-Propanediol,2-((6-chrysenylmethyl)amino)-2-methyl; Crisnatolum [Latin]; CRISNATOL; Crisnatolum. Product Category: Inhibitors. Appearance: Solid. CAS No. 96389-68-3. Molecular formula: C23H23NO2. Mole weight: 345.43. Purity: 0.96. IUPACName: 2-(chrysen-6-ylmethylamino)-2-methylpropane-1,3-diol. Canonical SMILES: CC(CO)(CO)NCC1=CC2=C(C=CC3=CC=CC=C32)C4=CC=CC=C41. Density: 1.242g/cm³. Product ID: ACM96389683. Alfa Chemistry ISO 9001:2015 Certified.
Crispine A
Crispine A. Group: Biochemicals. Alternative Names: 1,2,3,5,6,10b-Hexahydro-8,9-dimethoxypyrrolo[2,1-a]isoquinoline. Grades: Highly Purified. CAS No. 15889-93-7. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C14H19NO2. US Biological Life Sciences.
Worldwide
Cristatic acid
It is produced by the strain of Albaterllus cristatus. It can resist bacillus, tumor and hemolysis. Synonyms: NSC338268; NSC 338268; Cristatic acid-1. CAS No. 80557-13-7. Molecular formula: C23H28O5. Mole weight: 384.46.
Crizanlizumab
Crizanlizumab is an anti- P-selectin monoclonal antibody. Crizanlizumab binds to P-selectin and blocks its interaction with P-selectin glycoprotein ligand 1 (PSGL-1). Crizanlizumab prevents vaso-occlusive crises (VOCs) and can be used for research of sickle cell disease [1] [2] [3]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 1690318-25-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P9987.
Crizanlizumab
Crizanlizumab is a monoclonal antibody used for the prevention of vaso-occlusive crises (VOCs) in patients with sickle cell disease (SCD). Crizanlizumab binds to P-selectin, a cell adhesion molecule expressed on the surface of activated endothelial cells and platelets. By inhibiting P-selectin, crizanlizumab helps prevent the adhesion of sickle red blood cells to the endothelium and other blood cells, which is a key step in the initiation of VOCs in patients with SCD. It is indicated for the prevention of VOCs in patients with SCD. Vaso-occlusive crises are episodes of severe pain caused by the blockage of blood flow in small blood vessels, leading to tissue ischemia and organ damage. Crizanlizumab aims to reduce the frequency and severity of these painful episodes. Synonyms: Immunoglobulin G2, anti-(human P-selectin) (human-Mus musculus monoclonal SelG1 heavy chain), disulfide with human-Mus musculus monoclonal SelG1 light chain, dimer; Adakveo; Crizanlizumab-tmca; SEG 101; SelG 1. CAS No. 1690318-25-2.
Crizotinib is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor. Uses: Antineoplastic agents. Synonyms: PF-02341066; PF 02341066; PF02341066. Grade: >98%. CAS No. 877399-52-5. Molecular formula: C21H22Cl2FN5O. Mole weight: 450.343.
Crizotinib
Crizotinib (PF-02341066) is an orally bioavailable, ATP-competitive ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. Crizotinib is also a ROS1 inhibitor. Crizotinib has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066. CAS No. 877399-52-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878.
Crizotinib
Crizotinib is a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Group: Biochemicals. Alternative Names: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]-2-pyridinamine; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-(1-piperidin-4-yl-1H- pyrazol-4-yl)pyridin-2-ylamine; PF 02341066; PF 2341066; [3-[[ (R) -1- (2, 6-Dichloro-3-fluorophenyl) ethyl]oxy]-5-[1- (piperidin-4-yl) -1H-pyrazol-4-yl]pyridin-2-yl]amine. Grades: Highly Purified. CAS No. 877399-52-5. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Crizotinib-[d5]
Crizotinib-d5 is a labelled Crizotinib, a potent and selective dual inhibitor of mesenchymal-epithelial transition factor (c-MET) kinase and anaplastic lymphoma kinase (ALK). Crizotinib is a potential antitumor agent. Synonyms: Crizotinib D5; 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl-d4)-1H-pyrazol-4-yl]-2-pyridinamine-d5; (R)-3-[1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(piperidin-4-yl-d4)-1H-pyrazol-4-yl]pyridin-2-ylamine-d5; PF 02341066-d5; PF 2341066-d5. Grade: 95% by HPLC; 95% atom D. CAS No. 1395950-48-7. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37.
Crizotinib-D5
Crizotinib-D5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1395950-84-1. Molecular formula: C21H17D5Cl2FN5O. Mole weight: 455.37. Catalog: APB1395950841.
Crizotinib hydrochloride
Crizotinib hydrochloride (PF-02341066 hydrochloride) is an orally bioavailable, selective, and ATP-competitive dual ALK and c-Met inhibitor with IC 50 s of 20 and 8 nM, respectively. Crizotinib hydrochloride (PF-02341066 hydrochloride) inhibits tyrosine phosphorylation of NPM-ALK and tyrosine phosphorylation of c-Met with IC 50 s of 24 and 11 nM in cell-based assays, respectively. It is also a ROS proto-oncogene 1 (ROS1) inhibitor. Crizotinib hydrochloride (PF-02341066 hydrochloride) has effective tumor growth inhibition [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PF-02341066 hydrochloride. CAS No. 1415560-69-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-50878A.
Crizotinib hydrochloride
Crizotinib is inhibitor of the c-Met kinase and the NPM-ALK. Crizotinib inhibited cell proliferation in ALK-positive ALCL cells (IC50s=30 nM). Crizotinib is useful in treatment of anaplastic large-cell lymphoma. Synonyms: PF-02341066 hydrochloride; PF 02341066 hydrochloride; PF02341066 hydrochloride. Grade: >98%. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8.
Crizotinib Hydrochloride
Crizotinib Hydrochloride. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1415560-69-8. Molecular formula: C21H23Cl3FN5O. Mole weight: 486.8. Catalog: APB1415560698.
Crizotinib Impurity 26
Crizotinib Impurity 26. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1394346-24-7. Molecular formula: C13H8BrCl2FN2O3. Mole weight: 410.02. Catalog: APB1394346247.
Crizotinib Impurity 4
Crizotinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (S)-3-(1-(2,6-dichloro-3-fluorophenyl)ethoxy)-2-nitropyridine. CAS No. 1233484-06-4. Molecular formula: C13H9Cl2FN2O3. Mole weight: 331.13. Catalog: APB1233484064.