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| Product | Description | |
|---|---|---|
| CDDO-EA | CDDO-EA is an activator of Nrf2/ARE. It has neuroprotective effect. Synonyms: CDDO ethyl amide; RTA405; TP319; RTA 405; TP 319; RTA-405; TP-319. Grades: >98%. CAS No. 932730-51-3. Molecular formula: C33H46N2O3. Mole weight: 518.73. |  |
| CDDO Im | CDDO Im. Group: Biochemicals. Grades: Purified. CAS No. 443104-02-7. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| CDDO-Im | CDDO-Im (RTA-403) is an activator of Nrf2 and PPAR , with K i s of 232 and 344 nM for PPARα and PPARγ [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RTA-403; TP-235; CDDO-Imidazolide. CAS No. 443104-02-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-15725. |  |
| CDDO Imidazolide | CDDO Imidozolide is a synthetic triterpenoid as a Nrf2 signaling activator with highly active in suppressing cellular proliferation of human leukemia and breast cancer cell. Uses: Nrf2 signaling activator. Synonyms: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; (4aR,6aR,6aS,6bR,8aS,12aS,14bS)-8a-(imidazole-1-carbonyl)-4,4,6a,6b,11,11,14b-heptamethyl-3,13-dioxo-4a,5,6,6a,7,8,9,10,12,12a-decahydropicene-2-carbonitrile. Grades: ≥98 %. CAS No. 443104-02-7. Molecular formula: C34H43N3O3. Mole weight: 541.72. | |
| CDDO Imidazolide | CDDO Imidozolide (CDDO-Im) is a synthetic triterpenoid CDDO-Im inhibits fatty acid synthase expression and has antiproliferative and proapoptotic effects in human liposarcoma cells. Studies show that CDDO-Im is highly active in suppressing cellular proliferation of human leukemia and breast cancer cell lines as well as being an effective therapeutic agent in the treatment of other types of cancers. Group: Biochemicals. Alternative Names: 1-(2-Cyano-3,12,28-trioxooleana-1,9(11)-dien-28-yl)-1H-imidazole; 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid imidazolide; CDDO-Im; RTA 403; TP 235. Grades: Highly Purified. CAS No. 443104-02-7. Pack Sizes: 1mg. US Biological Life Sciences. | Worldwide |
| CDDO-Me (NSC 713200, Bardoxolone Methyl, BARD, Methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate) | A cell-permeable, bioavailable synthetic oleanane triterpenoid compound with anti-inflammatory, anti-tumor and cytoprotective properties. Shown to significantly reduce the expression of several inflammatory mediators, including IL-6, IL-10, IL-12, TNFalpha, Mip1alpha and others. Reverses high fat diet-induced type 2 diabetes in C57BL/6 mice (3mg/kg) and improves glucose homeostasis and insulin sensitivity. Down-regulates lipogenic gene expression in hepatocytes. Exhibits anti-proliferative activity in osteosarcoma cells (IC50 = 800, 150, 330, and 170nM in HOB-c, KHOS, KHOSR2, and U2OS cells, respectively). Enhances the effectiveness of chemotherapeutic agents by inducing intrinsic mitochondrial-dependent apoptotic pathway. Reported to interact with multi cellular targets, namely, Nrf2-Keap1, IKK, JAK-STAT, PPARg, ErbB2, PTEN, mTOR and Arp3 and covalently modify active site Cys residue via Michael addition. Group: Biochemicals. Grades: Highly Purified. CAS No. 218600-53-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDDO Methyl Ester | CDDO Methyl Ester is a synthetic triterpenoid that inhibits IκBα kinase and enhances apoptosis induced by TNF and chemotherapeutic agents through down-regulation of expression of nuclear factor κB-regulated gene products in human leukemic cells. CDDO Methyl Ester is a novel therapeutic agent in the treatment of acute myeloid leukemia and in the treatment of pancreatic cancer as well as other forms of cancer. Group: Biochemicals. Alternative Names: 2-Cyano-3,12-dioxooleana-1,9(11)-dien-28-oic Acid Methyl Ester; Bardoxolone Methyl; CDDO-Me; Methyl 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oate; NSC 713200; RTA 402. Grades: Highly Purified. CAS No. 218600-53-4. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDDO-TFEA | CDDO-TFEA is an Nrf2/ARE pathway activator. CDDO-TFEA inhibits BACH1 via reducing BACH1 nuclear levels while accumulating its cytoplasmic form. Synonyms: 2-cyano-3,12-dioxo-N-(2,2,2-trifluoroethyl)-oleana-1,9(11)-dien-28-amide; CDDO-trifluoroethyl-amide. CAS No. 932730-52-4. Molecular formula: C33H43F3N2O3. Mole weight: 572.7. | |
| CDDU-Me | CDDU-Me is an activator of the Nrf2 pathway, which induces the expression of cytoprotective genes regulated by Nrf-2 in vivo. It has anti-inflammatory, anti-tumor and cell protection properties. Synonyms: AC-31539. CAS No. 1616932-17-2. Molecular formula: C32H43NO4. Mole weight: 505.7. | |
| C-Demethyl clethodim | C-Demethyl clethodim. Group: Biochemicals. Alternative Names: (E) -2-[1-[[ (3-Chloro-2-propenyl) oxy]imino]ethyl]-5-[2- (ethylthio) propyl]-1, 3-cyclohexanedione. Grades: Highly Purified. CAS No. 112301-96-9. Pack Sizes: 5mg, 10mg, 25mg, 50mg, 100mg. Molecular Formula: C16H24ClNO3S. US Biological Life Sciences. | Worldwide |
| C-Desmethyl Metoprolol | C-Desmethyl Metoprolol. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Metoprolol USP Related Compound A, (2RS)-1-(Ethylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol, Metoprolol Tartrate Imp. A (EP),Metoprolol Succinate Imp. A (EP), Metoprolol Imp. A (EP), Metoprolol USP RC A. CAS No. 109632-08-8. IUPAC Name: 1-(ethylamino)-3-[4-(2-methoxyethyl)phenoxy]propan-2-ol. Molecular Formula: C14H23NO3. Mole Weight: 253.34. Catalog: APS109632088. SMILES: CCNCC(O)COc1ccc(CCOC)cc1. Format: Neat. |  |
| C-Desmethyl Metoprolol | A new byproduct detected in Metoprolol tartrate. Group: Biochemicals. Alternative Names: 1-(Ethylamino)-3-[4-(2-methoxyethyl)phenoxy]-2-propanol; H 173/09. Grades: Highly Purified. CAS No. 109632-08-8. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| CDFI | CDFI is an inhibitor of the lipid II flippase MurJ. CDFI potentiates the activity of β-lactams against MRSA [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1199797-92-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-156009. | |
| CDi(1-adamantyl)-n-butylphosphine | CDi(1-adamantyl)-n-butylphosphine. Group: Biochemicals. Alternative Names: Cataxium A. Grades: Highly Purified. CAS No. 321921-71-5. Pack Sizes: 500mg, 1g, 2g, 5g, 10g. Molecular Formula: C24H39P. US Biological Life Sciences. | Worldwide |
| c-di-2'-d-2''-O-Me-AMP | c-di-2'-d-2''-O-Me-AMP is an analogue of c-diAMP, the bacterial second messenger. Synonyms: 2'- Deoxy- 2''- O- methyl- cyclic diadenosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C21H26N10O11P2 (free acid). Mole weight: 656.5 (free acid). | |
| c-di-2'-dAMP | c-di-2'-dAMP is an analogue of c-diAMP, the bacterial second messenger. Synonyms: 2'- Deoxy- cyclic diadenosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. Molecular formula: C20H24N10O11P2 (free acid). Mole weight: 642.4 (free acid). | |
| c-di-2'-dGMP | c-di-2'-dGMP is an analogue of c-diGMP, the bacterial second messenger, which can be used to study ligand-receptor interactions. Synonyms: 2'- Deoxy- cyclic diguanosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 132182-18-4. Molecular formula: C20H24N10O13P2 (free acid). Mole weight: 674.4 (free acid). | |
| c-di-AMP | c-di-AMP is an agonist of stimulator of interferon genes (STING) for treating cancer. It is a second messenger in bacteria and archaea that is involved in the maintenance of osmotic pressure, response to DNA damage, and control of central metabolism, biofilm formation, acid stress resistance, and other functions. Synonyms: Cyclic diadenylate monophosphate; Cyclic diadenylate; Adenylic acid, cyclic ester; 3',5'-Cyclic diadenylic acid; Cyclic di-3',5'-adenylate; Cyclic di-AMP; Cyclic-di-AMP; Cyclic diadenosine monophosphate; (2R, 3R, 3aS, 7aR, 9R, 10R, 10aS, 14aR)-2, 9-bis(6-amino-9H-purin-9-yl)-3, 5, 10, 12-tetrahydroxyoctahydro-2H, 7H-difuro[3, 2-d:3', 2'-j][1, 3, 7, 9]tetraoxa[2, 8]diphosphacyclododecine 5,12-dioxide. Grades: ≥95%. CAS No. 54447-84-6. Molecular formula: C20H24N10O12P2. Mole weight: 658.41. | |
| CDIBA | CDIBA is a potent and selective cytosolic phospholipase A2 (cPLA2) inhibitor. Synonyms: 4-[2-(1-benzhydryl-5-chloro-2-methylindol-3-yl)ethoxy]benzoic acid. Grades: 99%. CAS No. 479422-22-5. Molecular formula: C31H26ClNO3. Mole weight: 496. | |
| c-Di-GMP | c-diGMP is a bacterial second messenger and a STING ligand. Synonyms: 3'-Guanylic acid, guanylyl-(3'?5')-, cyclic nucleotide; 5GP-5GP; Cyclic di-3',5'-guanylate; Cyclic diguanylate; Cyclic diguanylate monophosphate; Cyclic-di-GMP. Grades: ≥95%. CAS No. 61093-23-0. Molecular formula: C20H24N10O14P2. Mole weight: 690.41. | |
| c-di-GMP Fluorinated | A STING agonist. CAS No. 1334145-18-4. Molecular formula: C20H20F2N10O12P2.2Na. Mole weight: 738.36. | |
| c-di-IMP | c-diIMP is an analogue of c-diAMP and c-diGMP, the bacterial second messengers, which is potentially used as an adjuvant for mucosal vaccination. Synonyms: Cyclic diinosine monophosphate, sodium salt. Grades: ≥ 95% by HPLC. CAS No. 79940-41-3. Molecular formula: C20H22N8O14P2 (free acid). Mole weight: 660.4 (free acid). | |
| C-DIM12 | C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. Synonyms: C-DIM12; C-DIM 12; C-DIM-12. Grades: 98%. CAS No. 178946-89-9. Molecular formula: C23H17ClN2. Mole weight: 356.85. | |
| c-di-UMP | A STING agonist negative control. Synonyms: Cyclic di-uridine monophosphate, c-di-UMP sodium salt. CAS No. 73120-97-5. Molecular formula: C18H20N4O16P2.2Na. Mole weight: 656.3. | |
| CDK1/2 Inhibitor III | Cdk1/2 Inhibitor III is a selective inhibitor of Cdk1/2 with an IC50 of 2.1 μM for CDK1/cyclin B. It is a cell-permeable triazolo-diamine compound with anti-proliferative properties in various human cancer cells (IC50 = 20 nM, 35 nM and 92 nM in HCT-116, HeLa and A375 cells, respectively). Synonyms: Cyclin-dependent Kinase 1/2 Inhibitor III; 1H-1,2,4-Triazole-1-carbothioamide, 3-amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-; 3-Amino-5-[[4-(aminosulfonyl)phenyl]amino]-N-(2,6-difluorophenyl)-1H-1,2,4-triazole-1-carbothioamide; 3-amino-N-(2,6-difluorophenyl)-5-((4-sulfamoylphenyl)amino)-1H-1,2,4-triazole-1-carbothioamide. Grades: >95%. CAS No. 443798-55-8. Molecular formula: C15H13F2N7O2S2. Mole weight: 425.44. | |
| CDK1 Inhibitor | Cdk1 inhibitor is a cell-permeable indolylmethylene-2-indolinone derivative that exhibits potent anti-proliferative properties with IC50 of 2 μM. Cdk1 inhibitor acts as a selective and ATP-competitive inhibitor of Cdk1/cyclin B with IC50 of 5.8 μM. It also inhibits Cdk5 with IC50 of 25 μM. Synonyms: Cyclin-dependent Kinase 1 Inhibitor. Grades: ≥95%. CAS No. 220749-41-7. Molecular formula: C17H11ClN2O. Mole weight: 294.7. | |
| cdk1, phosphorylated (Thr14, Tyr15) Negative Control Peptide (Non-Phosphorlyated) | cdk1, phosphorylated (Thr14, Tyr15) Negative Control Peptide (Non-Phosphorlyated). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x100ug. US Biological Life Sciences. | Worldwide |
| cdk1, phosphorylated (Thr14, Tyr15) Positive Control Peptide (Phosphorlyated) | cdk1, phosphorylated (Thr14, Tyr15) Positive Control Peptide (Phosphorlyated). Group: Molecular Biology. Grades: Highly Purified. Pack Sizes: 1x100ug. US Biological Life Sciences. | Worldwide |
| CDK2 | CDK2 is a member of the eukaryotic S/T protein kinase family and its function is to catalyze the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S 0 /T 0 ) in a protein substrate. Uses: Scientific research. Group: Peptides. CAS No. 255064-79-0. Pack Sizes: 5 mg. Product ID: HY-P0235. | |
| CDK2 | CDK2, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Activity of CDK2 is maximal during S phase and G2; activated by interaction with cyclin E during the early stages of DNA synthesis to permit G1-S transition, and subsequently activated by cyclin A2 (cyclin A1 in germ cells) during the late stages of DNA replication to drive the transition from S phase to mitosis, the G2 phase. Synonyms: Cell division protein kinase 2; kinase Cdk2; p33 protein kinase; Anti-Gastric receptor I; Anti-H2R; His-His-Ala-Ser-Pro-Arg-Lys; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine. Grades: ≥95%. CAS No. 255064-79-0. Molecular formula: C35H57N15O9. Mole weight: 831.92. | |
| CDK2 acetate | CDK2 acetate, a member of the eukaryotic S/T protein kinase family, catalyzes the phosphoryl transfer of ATP γ-phosphate to serine or threonine hydroxyl (denoted as S0/T0) in a protein substrate. Synonyms: H-His-His-Ala-Ser-Pro-Arg-Lys-OH.CH3CO2H; L-histidyl-L-histidyl-L-alanyl-L-seryl-L-prolyl-L-arginyl-L-lysine acetic acid. Grades: ≥95%. Molecular formula: C37H61N15O11. Mole weight: 891.99. | |
| CDK2-IN-30 | CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC 50 value ≤20 nM. CDK2-IN-30 can be used in tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2640038-22-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164664. | |
| CDK2 inhibitor II | CDK2 inhibitor II. Group: Biochemicals. Alternative Names: 4- [2- (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazinyl] benzenesulfonamide; 4- [ (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazino] benzenesulfonamide; SC 221409. Grades: Highly Purified. CAS No. 222035-13-4. Pack Sizes: 5mg. Molecular Formula: C14H11BrN4O3S, Molecular Weight: 395.23. US Biological Life Sciences. | Worldwide |
| CDK2 Inhibitor II | The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2. It is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 with IC50 of 60 nM. Synonyms: Cyclin-dependent kinase 2 Inhibitor II; SC-221409. Grades: ≥95%. CAS No. 222035-13-4. Molecular formula: C14H11BrN4O3S. Mole weight: 395.2. | |
| CDK4/6-IN-15 | CDK4/6-IN-15 is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 potently inhibits cancer cells growth. CDK4/6-IN-15 arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2078047-99-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142076. | |
| CDK4/6 Inhibitor IV | Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine inhibitor for Cdk4/cyclin D1 with IC50 values of 1.5 μM and Cdk6/cyclin D1 with IC50 values of 5.6 μM. It exhibits blocking of pRb phosphorylation at Ser780 and Ser795. Cdk4/6 inhibitor IV can suppresses tumor growth in Xenograft mouse model. Synonyms: CINK4; Cyclin-dependent kinase 4/6 Inhibitor IV. Grades: ≥98%. CAS No. 359886-84-3. Molecular formula: C27H32N6O. Mole weight: 456.6. | |
| CDK4-IN-1 | CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer. Synonyms: CDK4 IN 1; LEE011 analog; CDK4-IN-1; CDK4IN-1; CDK4-IN1; CDK4IN1; CDK4 IN 1; 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine. Grades: >98%. CAS No. 1256963-02-6. Molecular formula: C22H29ClN8. Mole weight: 440.97. | |
| CDK4 Inhibitor | Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 of 0.8 μM. It also inhibits the activity of other Cdk's only at much higher concentrations (IC50 = 520 nM and 2.1 μM for Cdk2/E and Cdk1/B, respectively). Cdk4 inhibitor can inhibit tumor cells growth in HCT-116 and NCI-H460 cells (IC50 < 3.0 μM). Synonyms: 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grades: ≥90%. CAS No. 546102-60-7. Molecular formula: C20H10BrN3O2. Mole weight: 404.22. | |
| Cdk4 Inhibitor V (4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione) | A cell-permeable pyridinylmethylamino-isoquinoline dione compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of Cdk4/D1 activity with selectivity over Cdk2/E and Cdk1/B (IC50=0.03, 1.6 and 25.3uM, respectively). Shown to block the phosphorylation of Rb and induce growth arrest in HCT116 and MCF-7 cells (IC50=0.73 and 0.88uM). Displays desirable metabolic stability in rat liver microsomes and in the presence of NADPH and UDPGA cofactors (t1/2 > 30mins). Group: Biochemicals. Grades: Highly Purified. CAS No. 943746-57-4. Pack Sizes: 5mg. Molecular Formula: C??H??IN?O?. US Biological Life Sciences. | Worldwide |
| Cdk5 Substrate | Cdk5 Substrate is a biological active peptide. (substrate for the cdc2 protein kinase). Uses: Scientific research. Group: Peptides. CAS No. 164669-07-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2668. | |
| CDK7-IN-2 | CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2326428-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143587. | |
| CDK8-IN-13 | CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC 50 value of 51.9 nM. CDK8-IN-13 induces Apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 918523-75-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149974. | |
| CDK9-IN-1 | Among CDKs, CDK9 is a validated pathological target in HIV infection, inflammation and cardiac hypertrophy; however selective CDK9 inhibitors are still not available. We present a selective inhibitor family of CDK9 based on the 4-phenylamino-6- phenylpyrimidine nucleus. We show a convenient synthetic method to prepare a useful intermediate and its derivatisation resulting in novel compounds. The CDK9 inhibitory activity of the derivatives was measured in specific kinase assay and the CDK inhibitory profile of the best ones (IC50 > 100nM) was determined. The most selective compounds had high selectivity over CDK1, 2, 3, 5, 6, 7 and showed at least one order of magnitude higher inhibitory activity over CDK4 inhibition. The most selective molecules were examined in cytotoxicity assays and their ability to inhibit HIV-1 replication was determined in cellular assays. Synonyms: CDK9-IN-1; CDK9 IN 1. Grades: >98%. CAS No. 1415559-43-1. Molecular formula: C26H21N5O4S. Mole weight: 499.54. | |
| CDK9-IN-14 | CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC 50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2650640-17-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143585. | |
| CDK9-IN-2 | CDK9-IN-2 is a novel cyclin-dependent kinase 9(CDK9) inhibitor. Synonyms: CDK9 Inhibitor II; CDK9 Inhibitor 2; CDK9-In-2; CDK9-IN2. Grades: >98%. CAS No. 1263369-28-3. Molecular formula: C23H25ClFN5. Mole weight: 425.93. | |
| CDK9-IN-30 | CDK9-IN-30 is a CDK9 inhibitor that inhibits HIV-1 viral replication [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 748146-89-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-147131. | |
| CDK9-IN-34 | CDK9-IN-34 (Compound 1b) is an inhibitor for CDK9 with an IC 50 of 0.25 μM. CDK9-IN-34 exhibits cytotoxicity to cancer cell HCT116, MCF7 and K652 with IC 50 of 1.43, 3.01 and 50.27 μM, respectively. CDK9-IN-34 exhibits antiviral activity against coronavirus 229E with an IC 50 of 145.92 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 252725-86-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164619. | |
| CDK9-IN-6 | CDK9-IN-6, one of the CDK9 inhibitors, probably have potential activity in influencing cell cycle of T-type cells. Uses: Cdk9-in-6 is one of the cdk9 inhibitors that probably have potential activity in influencing cell cycle of t-type cells. Synonyms: CDK9-IN-6; SCHEMBL12466375; SCHEMBL15378321; SCHEMBL15378323; CS-4615; CS 4615; CS4615. Grades: 98%. CAS No. 1391855-95-0. Molecular formula: C27H37ClN6O2. Mole weight: 513.08. | |
| Cdk9 Inhibitor II | Cdk9 Inhibitor II. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cdk9 Inhibitor II, CHEMBL1823556, 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol, 4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol, 140651-18-9, F18, 2clx, 3tn8, SureCN3310182, SureCN12589685, UNII-ZG0O47K626, CAN508, CHEMBL215205, CTK8F0280, CAN-508, MolPort-009-019-369, HMS3229D19, DNC006929, IN1367, NSC741614. Product Category: Heterocyclic Organic Compound. Appearance: crystalline solid. CAS No. 140651-18-9. Molecular formula: C9H10N6O. Mole weight: 218.2. Purity: ≥95%. IUPACName: 4-[(3,5-diamino-1H-pyrazol-4-yl)hydrazinylidene]cyclohexa-2,5-dien-1-one. Canonical SMILES: C1=CC(=O)C=CC1=NNC2=C(NN=C2N)N. Product ID: ACM140651189. Alfa Chemistry ISO 9001:2015 Certified. |  |
| CDK/CRK Inhibitor | CDK/CRK inhibitor is an inhibitor of cyclin-dependent kinases (CDK) and CDK-related kinases (CRK) with IC50 values ranging from 9-839 nM. It is also a potent, selective & ATP-competitive inhibitor of CDKs. CDK/CRK inhibitor exhibits less than 20% inhibition of 60 non-CDK/CRK kinases at 1 μM. Synonyms: Cdk7 Inhibitor IV; Cyclin-dependent kinase 7 Inhibitor IV; Cyclin-dependent kinase/CDK-related kinase Inhibitor; RGB-286147; RGB 286147. Grades: ≥98%. CAS No. 784211-09-2. Molecular formula: C23H22Cl2N4O3. Mole weight: 473.4. | |
| CDKI-73 | CDKI-73 was cytotoxic to all of the CLL samples tested (n = 38) with a mean LD50 value of 0.08μM ± 0.10 μM following exposure to drug for 48h. In contrast, normal B-lymphocytes (n = 10) and CD34+ normal bone marrow cells (n = 5) were significantly less susceptible to the cytotoxic effects of CDKI-73. Treatment of CLL cells with 0.1 μM CDKI-73 for 4h inhibited the phosphorylation of cdk9 and ser2 of RNA polymerase II. CDKI-73 induces a rapid loss of MCL1 protein and this is mediated by significant inhibition at the level of gene transcription. However, this inhibition is not restricted to MCL1 as similar reductions in XIAP and CCND2 were also observed following exposure to CDKI-73 for 4h. CDKI-73 rapidly inhibited cellular CDK9 kinase activity and down-regulated the RNAPII phosphorylation. CDK9 shRNA was also found to down-regulate the Mnk1 expression. Both CDKI-73 and CDK9 shRNA decreased anti-apoptotic proteins Mcl-1 and Bcl-2 and induced apoptosis. CDKI-73 exhibited a favorable pharmacokinetic profile with oral bioavailability of F=56% following a single intravenous bolus dose at 2 mg/kg and an oral dose at 10 mg/kg in mice. Synonyms: CDKI-73; CDKI 73; CDKI73. Grades: >98%. CAS No. 1421693-22-2. Molecular formula: C15H15FN6O2S2. Mole weight: 394.45. | |
| CDKI-83 | CDKI-83 is a potent CDK9 inhibitor. The compound shows effective anti-proliferative activity in human tumour cell lines with GI50 <1 μM, and is capable of inducing apoptosis in A2780 human ovarian cancer cells as determined by the activated caspase-3, Annexin V/PI double staining and accumulated cells at the sub-G1 phase of cellcycle. The research results suggest that combined inhibition of CDK9 and CDK1 may result in the effective induction of apoptosis and CDKI-83 has the potential to be developed as an anti-cancer agent. Synonyms: CDKI83; CDKI 83. CAS No. 1189558-88-0. Molecular formula: C21H23N7O3S2. Mole weight: 485.58. | |
| CDK-IN-2 | CDK-IN-2 is a potent and sepecific CDK inhibitor. Synonyms: CDK inhibitor II. Grades: >98%. CAS No. 1269815-17-9. Molecular formula: C18H19ClFN3O2. Mole weight: 363.81. | |
| CDMT | It is a stable, crystalline compound, with good solubility in organic solvents, and is commercially available in large quantities. Uses: Peptide Synthesis. Group: Coupling Reagents. Alternative Names: 2-Chloro-4,6-dimethoxy-1,3,5-triazine. CAS No. 3140-73-6. |  Luxembourg Bio Technologies |
| CDN 1163 | CDN 1163 is an allosteric activator of sarco/endoplasmic reticulum Ca2+-ATPase (SERCA2), increasing Ca2+-ATPase activity and Ca2+ uptake by ER microsomes from obese mice. It reduces fasting glucose levels and adipose tissue weight, and increases energy expenditure in ob/ob mice. CDN 1163 has the potential to treat type-2 diabetes and metabolic dysfunction. Synonyms: CDN-1163; CDN 1163; CDN1163; 4-(1-Methylethoxy)-N-(2-methyl-8-quinolinyl)benzamide; 4-Isopropoxy-N-(2-methylquinolin-8-yl)benzamide. Grades: ≥98% by HPLC. CAS No. 892711-75-0. Molecular formula: C20H20N2O2. Mole weight: 320.38. | |
| cDNA Library | cDNA Library Construction Service can Include: Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| cDNA Library, Vector Preparation | cDNA Library Construction Service Includes: Group: Molecular Biology. US Biological Life Sciences. | Worldwide |
| CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase | This enzyme catalyses one of the steps in the biosynthesis of polar lipids in archaea, which are characterized by having an sn-glycerol 1-phosphate backbone rather than an sn-glycerol 3-phosphate backbone as is found in bacteria and eukaryotes. The enzyme requires Mg2+ and K+ for maximal activity. Group: Enzymes. Synonyms: carS (gene name); CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase; CTP:2,3-GG-GP ether cytidylyltransferase; CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase; CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase; CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase; CDP-unsaturated archaeol synthase; . Enzyme Commission Number: EC 2.7.7.67. CAS No. 329791-09-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3278; CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol synthase; EC 2.7.7.67; 329791-09-5; carS (gene name); CDP-2,3-di-O-geranylgeranyl-sn-glycerol synthase; CTP:2,3-GG-GP ether cytidylyltransferase; CTP:2,3-di-O-geranylgeranyl-sn-glycero-1-phosphate cytidyltransferase; CDP-2,3-bis-O-(geranylgeranyl)-sn-glycerol synthase; CTP:2,3-bis-O-(geranylgeranyl)-sn-glycero-1-phosphate cytidylyltransferase; CDP-unsaturated archaeol synthase; CDP-archaeol synthase (incorrect). Cat No: EXWM-3278. |  |
| CDP-4-dehydro-6-deoxyglucose reductase | The enzyme consists of two proteins. One forms an enzyme-bound adduct of the CDP-4-dehydro-6-deoxyglucose with pyridoxamine phosphate, in which the 3-hydroxy group has been removed. The second catalyses the reduction of this adduct by NAD(P)H and release of the CDP-4-dehydro-3,6-dideoxy-D-glucose and pyridoxamine phosphate. Group: Enzymes. Synonyms: CDP-4-keto-6-deoxyglucose reductase; cytidine diphospho-4-keto-6-deoxy-D-glucose reductase; cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase; CDP-4-keto-deoxy-glucose reductase; CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system; NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase. Enzyme Commission Number: EC 1.17.1.1. CAS No. 37256-87-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-1080; CDP-4-dehydro-6-deoxyglucose reductase; EC 1.17.1.1; 37256-87-4; CDP-4-keto-6-deoxyglucose reductase; cytidine diphospho-4-keto-6-deoxy-D-glucose reductase; cytidine diphosphate 4-keto-6-deoxy-D-glucose-3-dehydrogenase; CDP-4-keto-deoxy-glucose reductase; CDP-4-keto-6-deoxy-D-glucose-3-dehydrogenase system; NAD(P)H:CDP-4-keto-6-deoxy-D-glucose oxidoreductase. Cat No: EXWM-1080. | |
| CDP 840 hydrochloride | CDP 840 hydrochloride is a potent and selective inhibitor of phosphodiesterase 4 (PDE4) (IC50 = 12 nM). It competitively inhibits all PDE4 isoenzymes. Synonyms: CDP840; CDP-840; CDP 840; CDP840 HCl; CDP840HCl. 4-[(2R)-2-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-phenylethyl]-pyridine hydrochloride. Grades: ≥98% by HPLC. CAS No. 162542-90-7. Molecular formula: C25H27NO2.HCl. Mole weight: 409.95. | |
| CDP 840 hydrochloride | CDP 840 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 162542-90-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| CDP-abequose synthase | Isolated from Yersinia pseudotuberculosis and Salmonella enterica. Group: Enzymes. Synonyms: rfbJ (gene name). Enzyme Commission Number: EC 1.1.1.341. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0256; CDP-abequose synthase; EC 1.1.1.341; rfbJ (gene name). Cat No: EXWM-0256. | |
| CDP-β-S | CDP-β-S is a CDP binding proteins regulator with a higher stability. It is used for characterization of CDP-responsive receptors, determination of their stereospecificity and labelling with thio-reactive reporter groups. Synonyms: Cytidine- 5'- O- (2- thiodiphosphate), sodium salt. Grades: ≥ 95% by HPLC. CAS No. 497064-72-9. Molecular formula: C9H15N3O10P2S (free acid). Mole weight: 419.2 (free acid). | |
| CDP-diacylglycerol diphosphatase | This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides in phosphorus-containing anhydrides. The systematic name of this enzyme class is CDP-diacylglycerol phosphatidylhydrolase. Other names in common use include cytidine diphosphodiacylglycerol pyrophosphatase, and CDP diacylglycerol hydrolase. This enzyme participates in glycerophospholipid metabolism. Group: Enzymes. Synonyms: cytidine diphosphodiacylglycerol pyrophosphatase; CDP diacylglycerol hydrolase. Enzyme Commission Number: EC 3.6.1.26. CAS No. 62213-20-1. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4610; CDP-diacylglycerol diphosphatase; EC 3.6.1.26; 62213-20-1; cytidine diphosphodiacylglycerol pyrophosphatase; CDP diacylglycerol hydrolase. Cat No: EXWM-4610. | |
| CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase | The enzyme catalyses the committed step in the biosynthesis of acidic phospholipids known by the common names phophatidylglycerols and cardiolipins. Group: Enzymes. Synonyms: glycerophosphate phosphatidyltransferase; 3-phosphatidyl-1'-glycerol-3'-phosphate synthase; CDP. Enzyme Commission Number: EC 2.7.8.5. CAS No. 9068-49-9. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3343; CDP-diacylglycerol-glycerol-3-phosphate 1-phosphatidyltransferase; EC 2.7.8.5; 9068-49-9; glycerophosphate phosphatidyltransferase; 3-phosphatidyl-1'-glycerol-3'-phosphate synthase; CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDP-diglyceride):sn-glycerol-3-phosphate phosphatidyltransferase; phosphatidylglycerophosphate synthase; phosphatidylglycerolphosphate synthase; PGP synthase; CDP-diacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase; CDP-diacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase; glycerol phosphate phosphatidyltransferase; glycerol 3-phosphate phosphatidyltransferase; phosphatidylglycerol phosphate synthase; phosphatidylglycerol phosphate synthetase; phosphatidylglycerophosphate synthetase; sn-glycerol-3-phosphate phosphatidyltransferase. Cat No: EXWM-3 | |
| CDP-diacylglycerol-inositol 3-phosphatidyltransferase | This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. This enzyme participates in glycerophospholipid metabolism and phosphatidylinositol signaling system. Group: Enzymes. Synonyms: CDP-diglyceride-inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosph. Enzyme Commission Number: EC 2.7.8.11. CAS No. 9027-1-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3311; CDP-diacylglycerol-inositol 3-phosphatidyltransferase; EC 2.7.8.11; 9027-01-4; CDP-diglyceride-inositol phosphatidyltransferase; phosphatidylinositol synthase; CDP-diacylglycerol-inositol phosphatidyltransferase; CDP-diglyceride:inositol transferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase; CDP-DG:inositol transferase; cytidine diphosphodiglyceride-inositol phosphatidyltransferase; CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase; CDP-diglyceride-inositol transferase; cytidine diphosphoglyceride-inositol phosphatidyltransferase; cytidine diphosphoglyceride-inositol transferase. Cat No: EXWM-3311. | |
| CDP-diacylglycerol-serine O-phosphatidyltransferase | This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. This enzyme participates in glycine, serine and threonine metabolism and glycerophospholipid metabolism. Group: Enzymes. Synonyms: phosphatidylserine synthase; CDPdiglyceride-serine O-phosphatidyltransferase; PS synthase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase; phosphatidylserine synthetase; CDP-di. Enzyme Commission Number: EC 2.7.8.8. CAS No. 9068-48-8. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3346; CDP-diacylglycerol-serine O-phosphatidyltransferase; EC 2.7.8.8; 9068-48-8; phosphatidylserine synthase; CDPdiglyceride-serine O-phosphatidyltransferase; PS synthase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase; phosphatidylserine synthetase; CDP-diacylglycerol-L-serine O-phosphatidyltransferase; cytidine diphosphoglyceride-serine O-phosphatidyltransferase; CDP-diglyceride-L-serine phosphatidyltransferase; CDP-diglyceride:serine phosphatidyltransferase; cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase; CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase. Cat No: EXWM-3346. | |
| CDP-ethanolamine | CDP-ethanolamine, a pivotal intermediary in the biosynthesis of membrane phospholipids, assumes an indispensable function in preserving cellular membrane integrity. Clinical research evince that it ameliorates cognitive development in patients diagnosed with neurodegenerative conditions, notably Alzheimer's disease. Furthermore, it potentially mitigates glaucoma symptoms by diminishing intraocular pressure while enhancing blood flow, thereby ameliorating optic nerve functionality. Synonyms: Cytidine-5'-diphosphate ethanolamine; Cytidine-5'-diphosphateethanolamine. Grades: ≥ 95% by HPLC. CAS No. 3036-18-8. Molecular formula: C11H20N4O11P2. Mole weight: 446.25. | |
| CDP-Gel / CDP-Agarose | CDP-Gel is the CDP coupled to a polymeric gel by the terminal phosphate, which can be used in the affinity purification of sialyltransferases. Synonyms: Cytidine- 5'- O- diphosphate, immobilized on a polymeric matrix. | |
| CDP-glucose 4,6-dehydratase | Requires bound NAD+. Group: Enzymes. Synonyms: cytidine diphosphoglucose oxidoreductase; CDP-glucose 4,6-hydro-lyase. Enzyme Commission Number: EC 4.2.1.45. CAS No. 37259-55-5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-5034; CDP-glucose 4,6-dehydratase; EC 4.2.1.45; 37259-55-5; cytidine diphosphoglucose oxidoreductase; CDP-glucose 4,6-hydro-lyase. Cat No: EXWM-5034. | |
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