A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
CD532 is a potent Aurora A kinase inhibitor with an IC 50 of 45 nM. CD532 has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 also can directly interact with AURKA and induces a global conformational shift. CD532 can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1639009-81-6. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-112273.
CD532 hydrochloride
CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC 50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride also can directly interact with AURKA and induces a global conformational shift. CD532 hydrochloride can be used for the research of cancer [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2926498-81-7. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-112273A.
CD532 hydrochloride
CD532 hydrochloride is a potent Aurora A kinase inhibitor with an IC50 of 45 nM. CD532 hydrochloride has the dual effect of blocking Aurora A kinase activity and driving degradation of MYCN. CD532 hydrochloride can also directly interact with AURKA and induces a global conformational shift. Synonyms: CD532 (hydrochloride); CD532 hydrochloride; EX-A8075A; HY-112273A; MS-30172; CS-0202740; 2926498-81-7. Grade: 99%. Molecular formula: C26H26ClF3N8O. Mole weight: 558.99.
CD59 glycoprotein precursor (106-114) is a peptide derived from CD59 glycoprotein precursor which is a potent inhibitor of the complement membrane attack complex (MAC) action. CD59 glycoprotein is involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase. Synonyms: HRF-20 (106-114); Membrane attack complex inhibition factor (106-114).
CD5 human
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
CD73-IN-11 is a CD73 inhibitor with an IC50 of ≤316.23 nM for the human enzyme in a cell-free assay. It can be used in cancer treatment. (Extracted from patent WO 2017153952 A1, example 80). Synonyms: VPS34 inhibitor; 5-[N-(2-Cyclopropyl-6-indolyl)sulfamoyl]-2-hydroxybenzamide; CD73 inhibitor 1; Benzamide, 5-[[(2-cyclopropyl-1H-indol-6-yl)amino]sulfonyl]-2-hydroxy-. Grade: ≥98%. CAS No. 2132396-40-6. Molecular formula: C18H17N3O4S. Mole weight: 371.41.
CD73-IN-2
CD73-IN-2 is a potent CD73 inhibitor with an IC50 of 0.09 nM. Synonyms: ((((2R,3S,4R,5R)-5-((6-chloro-4-(cyclopentylamino)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3,4-dihydroxytetrahydrofuran-2-yl)methoxy)methyl)phosphonic acid. Molecular formula: C17H25ClN5O7P. Mole weight: 477.84.
CD73-IN-4
CD73-IN-4 is a potent and selective methylenephosphonic acid CD73 inhibitor with an IC50 of 2.6 nM for human. It has potential in cancer immunology research. Synonyms: 1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 6-chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-; 6-Chloro-N-cyclopentyl-1-[5-O-(phosphonomethyl)-β-D-ribofuranosyl]-1H-pyrazolo[3,4-d]pyrimidin-4-amine. Grade: ≥97%. CAS No. 2216764-29-1. Molecular formula: C16H23ClN5O7P. Mole weight: 463.81.
CD73-IN-5
CD73-IN-5 is a potent and selective non-nucleotide small molecule CD73 inhibitor with an IC50 of 19 nM. Synonyms: Benzonitrile, 4-[[5-[4-fluoro-1-(1H-indazol-6-yl)-1H-benzotriazol-6-yl]-1H-pyrazol-1-yl]methyl]-. CAS No. 2412019-99-7. Molecular formula: C24H15FN8. Mole weight: 434.43.
recombinant, expressed in E. coli, ?80% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
CDAP
CDAP is an organic cyanylating reagent that can be used for preparation of solid phase affinity reagents, modification of protein thiols and nucleotide delivery. CDAP also activates polysaccharides with a variety of chemical properties. CDAP can be used to prepare conjugate vaccines and other immune reagents [1]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 59016-56-7. Pack Sizes: 100 mg. Product ID: HY-W012184.
CDBP
CDBP. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 4,4'-Bis(carbazol-9-yl)-2,2'-dimethylbiphenyl. Product Category: Organic Light Emitting Diode (OLED). CAS No. 604785-54-8. Molecular formula: C38H28N2. Mole weight: 512.64 g/mol. Product ID: ACM604785548. Alfa Chemistry ISO 9001:2015 Certified. Categories: 4,4'-BIS(9-CARBAZOLYL)-2,2'-DIMETHYLBIPHENYL, CD Projekt.
Cdc25A (80-93) (human)
Cdc25A abundance fluctuates periodically during the cell division cycle and is mainly regulated by the ubiquitin-proteasome system, through the action of two ubiquitin ligase complexes, which later promote complex/cyclosome and Skp1/Cul1/F-box proteins. Due to the presence of the destruction motif (KEN-box) in Cdc25A, ubiquitination and degradation occur at the mitotic outlet and G1, while phosphorylation events modulate the stability of Cdc25A protein in the S phase, both in undisturbed cells and in cells exposed to DNA damage agents or DNA replication inhibitors. Synonyms: H-Thr-Asp-Ser-Gly-Phe-Cys-Leu-Asp-Ser-Pro-Gly-Pro-Leu-Asp-OH. Grade: ≥95%. CAS No. 851538-67-5. Molecular formula: C60H90N14O24S. Mole weight: 1423.52.
Cdc25 Inhibitor IV, NSC 95397 (2,3-Bis(2-hydroxyethylthio)-1,4-naphthalenedione, PTP Inhibitor XXIX)
A cell-permeable, para-naphthoquinone that has been reported to inhibit protein tyrosine phosphatase activity, including Cdc25 dual specificity phosphatase (Ki=32nM, 96nM, and 40nM for Cdc25A, -B, and -C, respectively) and blocks G2M transition in murine carcinoma cells. In addition, it is shown to inhibit S100A4 binding to myosin-IIA via covalent modification of cysteine residues, Cys81 and Cys86, in the target binding cleft (IC50=1.8uM). It demonstrates inhibitory activity against S100A4-mediated depolymerization of myosin-IIA filaments. Group: Biochemicals. Grades: Highly Purified. CAS No. 93718-83-3. Pack Sizes: 10mg. Molecular Formula: C??H??O?S?, Molecular Weight: 310.4. US Biological Life Sciences.
Worldwide
Cdc2-Like Kinase Inhibitor IV, KH-CB19
The Cdc2-Like Kinase Inhibitor IV, KH-CB19 controls the biological activity of Cdc2-Like KInase. This small molecule/inhibitor is primarily used for Cell Structure applications. Group: Fluorescence/luminescence spectroscopy.
Cdc2-Like Kinase Inhibitor IV, KH-CB19 ((E)-Ethyl-3-(2-amino-1-cyanovinyl)-6,7-dichloro-1-methyl-1H-indole-2-carboxylate)
A cell-permeable N-methylindolyl-enaminonitrile compound that acts as a potent, non-ATP mimetic binding and reversible inhibitor of Clk1 and Dyk1A (IC50=19.7 and 55.2nM, respectively) with moderate to excellent selectivity over Clk3 (IC50=530nM) and against 71-kinases. Shown to suppress phosphorylation of Ser/Arg-rich (SR) proteins, regulate alternative splicing and lower both full-length and alternatively spliced human tissue factor isoforms much more efficiently than Cdc2-Like Kinase Inhibitor, TG003 in HMEC-1 cells. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. Molecular Formula: C??H??Cl?N?O?, Molecular Weight: 338.2. US Biological Life Sciences.
Worldwide
CDC42, GST tagged human
recombinant, expressed in E. coli, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy.
Cdc7-IN-1 is a highly potent, selective and ATP competitive Cdc7 kinase inhibitor, with an IC50 of 0.6 nM at 1 mM ATP and a slow deceleration characteristic. It can effectively inhibit the activity of Cdc7 in cancer cells and induce cell death. Synonyms: Ethyl (5Z)-2-[(2-chlorophenyl)amino]-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 2-[(2-chlorophenyl)amino]-4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, ethyl ester, (5Z)-. Grade: ≥99%. CAS No. 1402055-25-7. Molecular formula: C21H16ClN3O4. Mole weight: 409.82.
Cdc7-IN-3
Cdc7-IN-3, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-B). Synonyms: Isopropyl (5Z)-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, 1-methylethyl ester, (5Z)-. Grade: ≥95%. CAS No. 1402057-87-7. Molecular formula: C20H22N4O5. Mole weight: 398.41.
Cdc7-IN-4
Cdc7-IN-4, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-C). Synonyms: Isopropyl (5Z)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-{[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino}-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-[[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino]-, 1-methylethyl ester, (5Z)-. Grade: ≥97%. CAS No. 1402059-21-5. Molecular formula: C22H24F3N5O4. Mole weight: 479.45.
Cdc7-IN-5
Cdc7-IN-5, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-B). Synonyms: Ethyl (5Z)-2-(7-methoxy-3,4-dihydro-2(1H)-isoquinolinyl)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 2-(3,4-dihydro-7-methoxy-2(1H)-isoquinolinyl)-4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, ethyl ester, (5Z)-. Grade: ≥95%. CAS No. 1402057-86-6. Molecular formula: C25H23N3O5. Mole weight: 445.47.
Cdc7-IN-6
Cdc7-IN-6 is a potent Cdc7 kinase inhibitor (IC50 = 4 nM) with antitumor activity. (Extracted from patent WO2019165473A1, compound I-D). Synonyms: AS-0141; Ethyl (5Z)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-{[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino}-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-2-[[4-(2,2,2-trifluoroethyl)-1-piperazinyl]amino]-, ethyl ester, (5Z)-. Grade: ≥97%. CAS No. 1402057-88-8. Molecular formula: C21H22F3N5O4. Mole weight: 465.43.
Cdc7-IN-7
Cdc7-IN-7, a potent inhibitor of Cdc7 kinase, is a serine-threonine protein kinase enzyme that is required for the initiation of DNA replication during the cell cycle. (Extracted from patent WO2019165473A1, compound I-E). Synonyms: Cyclopropylmethyl (5Z)-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-4,5-dihydro-3-furancarboxylate; 3-Furancarboxylic acid, 4,5-dihydro-2-(4-morpholinylamino)-4-oxo-5-(1H-pyrrolo[2,3-b]pyridin-3-ylmethylene)-, cyclopropylmethyl ester, (5Z)-. Grade: ≥97%. CAS No. 1402059-17-9. Molecular formula: C21H22N4O5. Mole weight: 410.42.
CDC801
A potent, orally active and dual inhibitor of phosphodiesterase 4 (PDE4) (IC50= 1.1 μM) and tumor necrosis factor-α (TNF-α) (IC50= 2.5 μM). Synonyms: CDC801; CDC 801; CDC-801; 3-(3-cyclopentyloxy-4-methoxyphenyl)-3-(1,3-dioxoisoindol-2-yl)propanamide. CAS No. 192819-27-5. Molecular formula: C23H24N2O5. Mole weight: 408.45.
CDCFDA
CDCFDA. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(and-6)-Carboxy-2',7'-dichlorofluoresceindiacetate. Product Category: Fluorescein Fluorophores. CAS No. 127770-45-0. Molecular formula: C25H14Cl2O9. Mole weight: 529.28. Purity: 95%+. Product ID: ACM127770450-2. Alfa Chemistry ISO 9001:2015 Certified. Categories: 144489-09-8, CD CF Salmantino.
CDCFDA, SE
CDCFDA, SE. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 5-(and-6)-Carboxy-2',7'-dichlorofluorescein diacetate, succinimidyl ester. Product Category: Fluorescein Fluorophores. Molecular formula: C29H17Cl2NO11. Mole weight: 626.35. Product ID: ACMA00013920. Alfa Chemistry ISO 9001:2015 Certified.
CDD0102
CDD0102 is a selective M1 agonist which stimulated the secretion of APP from CHO-K1 cells expressing M1 receptors and penetrated into the brain following i.p. administration in rodents. Synonyms: CDD0102; CDD 0102; CDD-0102; 3-ethyl-5-(1,4,5,6-tetrahydropyrimidin-5-yl)-1,2,4-oxadiazole; 5-(3-ethyl-1,2,4-oxadiazol-5-yl)-1,4,5,6-tetrahydropyrimidine; CDD-0102A. CAS No. 146422-58-4. Molecular formula: C8H12N4O. Mole weight: 180.21.
CDD-1653
CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3034216-44-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-164145.
CDD3505
CDD3505 is an inducer of hepatic cytochrome P450IIIA (CYP3A) activity that elevates high density lipoprotein cholesterol (HDL). Uses: Cytochrome p-450 enzyme inhibitors. Synonyms: 4-Nitro-1-trityl-1H-imidazole; 1-Trityl-4-nitroimidazole. CAS No. 173865-33-3. Molecular formula: C22H17N3O2. Mole weight: 355.39.
CDDO-2-P-Im is an orally active inhibitor of necroptosis. Synonyms: CDDO-2P-Im. Grade: 98%. CAS No. 1883650-96-1. Molecular formula: C39H46N4O3. Mole weight: 618.8.
CDDO-3-P-Im
CDDO-3-P-Im is an orally active inhibitor of necroptosis. Synonyms: CDDO-3P-Im. Grade: 98%. CAS No. 1883650-95-0. Molecular formula: C39H46N4O3. Mole weight: 618.8.
CDDO-DhTFEA
CDDO-DhTFEA can effectively activate Nrf2 and inhibit the pro-inflammatory transcription factor NF-κB. Synonyms: RTA Dh404; RTA Dh404RTA Dh404. CAS No. 1191265-33-4. Molecular formula: C33H45F3N2O3. Mole weight: 574.7.