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| Product | Description | |
|---|---|---|
| CDK2/CyclinA1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| CDK2/Cyclin A2, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2/CyclinE1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2 degrader 1 | CDK2 degrader 1 (Compound 3) is a selective CDK2 molecular glue degrader with a Dmax (CDK2) of > 80% and a Ki (CRBN) > 1 ?M. CDK2 degrader 1 binds to cereblon to induce ubiquitination and subsequent proteasomal degradation of the CDK2. CDK2 degrader 1 is used in the research of a wide range of cancers[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3036604-59-5. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg. Product ID: HY-163814. |  |
| CDK2, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK2-IN-30 | CDK2-IN-30 (Formula (I)) is a CDK2 inhibitor with an IC 50 value ≤20 nM. CDK2-IN-30 can be used in tumor research [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2640038-22-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-164664. | |
| CDK2-IN-4 | CDK2-IN-4 (compound 73) is a potent and selective CDK2 inhibitor with an IC50 of 44 nM for CDK2/cyclin A, shows 2,000-fold selectivity over CDK1/cyclin B (IC50=86 uM)[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2079895-42-2. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-117535. | |
| CDK2-IN-7 | CDK2-IN-7 is a cyclin-dependent kinases 2 (CDK2) inhibitor (IC50 <50 nM) for the treatment of cancer. Synonyms: Benzenesulfonamide, 4-[[7'-[(1R,2S)-2-hydroxy-2-methylcyclopentyl]-6'-oxospiro[cyclopropane-1,5'-[5H]pyrrolo[2,3-d]pyrimidine]-2'(7'H)-yl]amino]-N-(3-methyl-3-azetidinyl)-, rel-; 4-[[7'-[(1R,2S)-2-hydroxy-2-methylcyclopentyl]-6'-oxospiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-2'-yl]amino]-N-(3-methylazetidin-3-yl)benzenesulfonamide. CAS No. 2498658-13-0. Molecular formula: C24H30N6O4S. Mole weight: 498.60. |  |
| CDK2-IN-73 | CDK2-IN-73 is a potent and selective inhibitor of CDK2 with IC50 of 44 nM for CDK2. Synonyms: CDK2 inhibitor 73; CDK2-IN-4. CAS No. 2079895-42-2. Molecular formula: C23H18N6O2S. Mole weight: 442.49. | |
| CDK2 inhibitor II | CDK2 inhibitor II. Group: Biochemicals. Alternative Names: 4- [2- (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazinyl] benzenesulfonamide; 4- [ (5-Bromo-1, 2-dihydro-2-oxo-3H-indol-3-ylidene) hydrazino] benzenesulfonamide; SC 221409. Grades: Highly Purified. CAS No. 222035-13-4. Pack Sizes: 5mg. Molecular Formula: C14H11BrN4O3S, Molecular Weight: 395.23. US Biological Life Sciences. |  Worldwide |
| CDK2 Inhibitor II | The cyclin-dependent kinase 2 (Cdk2) works with cyclins A or E to regulate S phase and G2-M transition during the cell cycle. Cdk2 Inhibitor II is a potent, cell-permeable, ATP-competitive, and selective inhibitor of Cdk2. It is a 3-(benzylidne)indolin-2-one analog that selectively and potently inhibits Cdk2 with IC50 of 60 nM. Synonyms: Cyclin-dependent kinase 2 Inhibitor II; SC-221409. Grade: ≥95%. CAS No. 222035-13-4. Molecular formula: C14H11BrN4O3S. Mole weight: 395.2. | |
| Cdk2 Inhibitor II - CAS 222035-13-4 | The Cdk2 Inhibitor II, also referenced under CAS 222035-13-4, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk2 Inhibitor III - CAS 199986-75-9 | The Cdk2 Inhibitor III, also referenced under CAS 199986-75-9, controls the biological activity of Cdk2. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK3/CyclinE1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/6/1 Inhibitor | CDK4/6/1 Inhibitor is a CDK4/6 inhibitor with IC50s of 3 and 1 nM, respectively. It is a potent anti-proliferative agent that arrests U87MG cell line exclusively in G1. Synonyms: 5-Fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-indol]-5'-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-2-pyrimidinamine; 2-Pyrimidinamine, 5-fluoro-4-(7'-fluoro-2'-methylspiro[cyclopentane-1,3'-[3H]indol]-5'-yl)-N-[5-(1-methyl-4-piperidinyl)-2-pyridinyl]-. Grade: ≥96%. CAS No. 2099128-41-1. Molecular formula: C28H30F2N6. Mole weight: 488.57. | |
| CDK4/6-IN-15 | CDK4/6-IN-15 is an orally active and selective CDK4/6 inhibitor. CDK4/6-IN-15 potently inhibits cancer cells growth. CDK4/6-IN-15 arrests cell cycle at G1 phase and suppresses retinoblastoma tumour suppressor protein (Rb) phosphorylation at S780 and E2 factor (E2F)-regulated gene expression [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2078047-99-9. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-142076. | |
| CDK4/6-IN-2 | CDK4/6-IN-2 is a potent CDK4 and CDK6 inhibitor with IC50s of 2.7 and 16 nM, respectively. (Extracted from patent US20180000819A1, Compound 1). Synonyms: 5-[(4-Ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzimidazol-6-yl)-2-pyridinyl]-2-pyrimidinamine; 2-Pyrimidinamine, 5-[(4-ethyl-1-piperazinyl)methyl]-N-[5-fluoro-4-[4-fluoro-2-methyl-1-(1-methylethyl)-1H-benzimidazol-6-yl]-2-pyridinyl]-. Grade: ≥97%. CAS No. 1800506-48-2. Molecular formula: C27H32F2N8. Mole weight: 506.59. | |
| CDK4/6-IN-3 | CDK4/6-IN-3 is a brain-penetrant CDK4/CDK6 inhibitor with Kis of <0.3 and 2.2 nM, respectively. It can be used for the treatment of glioblastoma. CDK4/6-IN-3 inhibits CDK1 with a Ki of 110 nM. Synonyms: 2-Pyrimidinamine, N-[5-(6-ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-5,6,7,8-tetrahydro-4-methyl-4H-pyrazolo[1,5-a]azepin-3-yl]-; N-[5-(6-Ethyl-2,6-diazaspiro[3.3]hept-2-yl)-2-pyridinyl]-5-fluoro-4-[(4R)-4-methyl-5,6,7,8-tetrahydro-4H-pyrazolo[1,5-a]azepin-3-yl]-2-pyrimidinamine. Grade: ≥97%. CAS No. 2366237-37-6. Molecular formula: C25H31FN8. Mole weight: 462.57. | |
| CDK4/6-IN-5 | CDK4/6-IN-5 is a potent inhibitor of CDK4 and CDK6 with Kis of 0.2 and 4.4 nM for CDK4/Cyclin D1 and CDK6/Cyclin D3, respectively. (Extracted from patent WO2019207463A1, example A93). Synonyms: 1H-Benzimidazole-2-methanol, 6-[5-chloro-2-[[(3R,4R)-3-hydroxy-1-(methylsulfonyl)-4-piperidinyl]amino]-4-pyrimidinyl]-4-fluoro-α-methyl-1-(1-methylethyl)-, (αR)-. Grade: 96%. CAS No. 2380321-50-4. Molecular formula: C22H28ClFN6O4S. Mole weight: 527.01. | |
| CDK4/6 Inhibitor IV | Cdk4/6 inhibitor IV is a cell-permeable triaminopyrimidine inhibitor for Cdk4/cyclin D1 with IC50 values of 1.5 μM and Cdk6/cyclin D1 with IC50 values of 5.6 μM. It exhibits blocking of pRb phosphorylation at Ser780 and Ser795. Cdk4/6 inhibitor IV can suppresses tumor growth in Xenograft mouse model. Synonyms: CINK4; Cyclin-dependent kinase 4/6 Inhibitor IV. Grade: ≥98%. CAS No. 359886-84-3. Molecular formula: C27H32N6O. Mole weight: 456.6. | |
| Cdk4/6 Inhibitor IV - CAS 359886-84-3 | The Cdk4/6 Inhibitor IV, also referenced under CAS 359886-84-3, controls the biological activity of Cdk4/6. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/Cyclin D1, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/Cyclin D1 active human | recombinant, expressed in baculovirus infected Sf9 cells, ?90% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| CDK4/CyclinD3, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4-IN-1 | CDK 4/6 Inhibitor is a part of a group of compounds that exhibits selective inhibitory properties towards Cyclin-Dependent Kinases 4 & 6. These compounds are most commonly used to treat patients with breast cancer. Synonyms: CDK4 IN 1; LEE011 analog; CDK4-IN-1; CDK4IN-1; CDK4-IN1; CDK4IN1; CDK4 IN 1; 4-[5-Chloro-3-(1-methylethyl)-1H-pyrazol-4-yl]-N-[5-[4-(dimethylamino)-1-piperidinyl]-2-pyridinyl]-2-pyrimidinamine. Grade: >98%. CAS No. 1256963-02-6. Molecular formula: C22H29ClN8. Mole weight: 440.97. | |
| CDK4 Inhibitor | Cdk4 inhibitor is a cell-permeable, asymmetrical indolocarbazole that exhibits antiproliferative activity by blocking cyclin D1/Cdk4 with an IC50 of 0.8 μM. It also inhibits the activity of other Cdk's only at much higher concentrations (IC50 = 520 nM and 2.1 μM for Cdk2/E and Cdk1/B, respectively). Cdk4 inhibitor can inhibit tumor cells growth in HCT-116 and NCI-H460 cells (IC50 < 3.0 μM). Synonyms: 2-Bromo-12,13-dihydro-5H-indolo[2,3-a]pyrrolo[3,4-c]carbazole-5,7(6H)-dione. Grade: ≥90%. CAS No. 546102-60-7. Molecular formula: C20H10BrN3O2. Mole weight: 404.22. | |
| Cdk4 Inhibitor III - CAS 265312-55-8 | The Cdk4 Inhibitor III, also referenced under CAS 265312-55-8, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk4 Inhibitor II, NSC 625987 - CAS 141992-47-4 | The Cdk4 Inhibitor II, NSC 625987, also referenced under CAS 141992-47-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk4 Inhibitor V (4-(((4-Hydroxy-5-propoxy-pyridin-2-ylmethyl)-amino)-methylene)-6-iodo-4H-isoquinoline-1,3-dione) | A cell-permeable pyridinylmethylamino-isoquinoline dione compound that acts as a potent, ATP-binding site targeting and reversible inhibitor of Cdk4/D1 activity with selectivity over Cdk2/E and Cdk1/B (IC50=0.03, 1.6 and 25.3uM, respectively). Shown to block the phosphorylation of Rb and induce growth arrest in HCT116 and MCF-7 cells (IC50=0.73 and 0.88uM). Displays desirable metabolic stability in rat liver microsomes and in the presence of NADPH and UDPGA cofactors (t1/2 > 30mins). Group: Biochemicals. Grades: Highly Purified. CAS No. 943746-57-4. Pack Sizes: 5mg. Molecular Formula: C??H??IN?O?. US Biological Life Sciences. | Worldwide |
| Cdk4 Inhibitor V - CAS 943746-57-4 | The Cdk4 Inhibitor V, also referenced under CAS 943746-57-4, controls the biological activity of Cdk4. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK4-R24C (23-32) | CDK4-R24C (23-32) is a peptide derived from CDK4-R24C. The common mutation in CDK4 (CDK4R24C) in melanoma inhibits the interaction with p16INK4A and thus leads to constitutive activation. | |
| CDK5-IN-1 | CDK5-IN-1 is a potent CDK5 inhibitor with an activity of less than 10 nM against CDK5. It is used in kidney diseases research. Synonyms: 1H-Pyrazole-3-methanol, 1-[3-fluoro-4-[[2-[(1-methyl-4-piperidinyl)sulfonyl]-1,6-naphthyridin-7-yl]amino]phenyl]-. CAS No. 2639540-19-3. Molecular formula: C24H25FN6O3S. Mole weight: 496.56. | |
| CDK5 inhibitor 20-223 | CDK5 inhibitor 20-223, an effective anti-colorectal cancer (CRC) agent, is a potent CDK2 and CDK5 inhibitor with IC50s of 6.0 and 8.8 nM, respectively. Synonyms: 2-Naphthaleneacetamide, N-(5-cyclobutyl-1H-pyrazol-3-yl)-; CDK5-IN-20-223; N-(5-Cyclobutyl-1H-pyrazol-3-yl)-2-(2-naphthyl)acetamide. Grade: ≥99%. CAS No. 865317-30-2. Molecular formula: C19H19N3O. Mole weight: 305.37. | |
| CDK5/p25, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK5/p35., active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk5 Substrate | Cdk5 Substrate is a biological active peptide. (substrate for the cdc2 protein kinase). Uses: Scientific research. Group: Peptides. CAS No. 164669-07-2. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P2668. | |
| CDK6/9-IN-1 | CDK6/9-IN-1 is an orally active dual inhibitor of CDK6 and CDK9, with IC50s of 40.5 and 39.5 nM, respectively. Synonyms: Acetamide, N-[3-[[5-chloro-2-[[5-(4-methyl-1-piperazinyl)-2-pyridinyl]amino]-4-pyrimidinyl]amino]phenyl]-. CAS No. 2414373-55-8. Molecular formula: C22H25ClN8O. Mole weight: 452.94. | |
| CDK6/CyclinD1, active, His/GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK7/9-IN-1 | CDK7/9-IN-1 is a CDK7/9 inhibitor that can be used in cancer research, selectively inhibiting CDK7 over CDK9. CDK7/9-IN-1 inhibits CDK7 with IC50s of 0.0656 μM and 0.00574 μM without pre-incubation and after 3 hours pre-incubation, respectively. CDK7/9-IN-1 inhibits CDK9 with an IC50 of 2.14 μM after 3 hours pre-incubation. Synonyms: 2-Propen-1-one, 1-[(2R)-2-[[4-[[3-(1-methylethyl)-6-(trifluoromethyl)imidazo[1,2-a]pyridin-8-yl]amino]-1-piperidinyl]methyl]-4-morpholinyl]-. CAS No. 2747919-19-1. Molecular formula: C24H32F3N5O2. Mole weight: 479.54. | |
| CDK7/Cyclin H1/MNAT1, active, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK7-IN-1 | CDK7-IN-1 is an analog of YKL-5-124 and a CDK7 inhibitor with an IC50 of less than 100 nM. (Extracted from patent WO 2016105528 A2, Compound 215). Synonyms: Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-6,6-dimethyl-3-[[4-[(1-oxopropyl)amino]benzoyl]amino]-. Grade: ≥98%. CAS No. 1957203-02-9. Molecular formula: C28H35N7O3. Mole weight: 517.62. | |
| CDK7-IN-10 | CDK7-IN-10 is a CDK7 inhibitor with an IC50 of <100 nM, and has the potential to inhibit cell growth and induce apoptosis. (Extracted from patent WO2021016388A1, compound I-1). Synonyms: Pyrrolo[3,4-c]pyrazole-5(1H)-carboxamide, N-[(1S)-2-(dimethylamino)-1-phenylethyl]-4,6-dihydro-1,6,6-trimethyl-3-[[4-[(1-oxo-2-propen-1-yl)amino]benzoyl]amino]-. CAS No. 2588110-62-5. Molecular formula: C29H35N7O3. Mole weight: 529.63. | |
| CDK7-IN-2 | CDK7-IN-2 is a potent inhibitor of CDK7. CDK7 is implicated in both temporal control of the cell cycle and transcriptional activity. CDK7 is implicated in the transcriptional initiation process by phosphorylation of Rbpl subunit of RNA Polymerase II (RNAPII). CDK7 has the potential for the research of cancer disease, in particular aggressive and hard- to-treat cancers (extracted from patent WO2019099298A1, compound 1) [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2326428-19-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-143587. | |
| CDK7-IN-2 hydrochloride hydrate | CDK7-IN-2 hydrochloride hydrate is a potent and selective CDK7 inhibitor with potent anticancer activity. Synonyms: (S,E)-1-(4-(dimethylamino)but-2-enoyl)pyrrolidin-3-yl 4-((3-isopropyl-5-methylpyrazolo[1,5-a]pyrimidin-7-yl)amino)piperidine-1-carboxylate hydrochloride hydrate. CAS No. 2326428-24-2. Molecular formula: C26H42ClN7O4. Mole weight: 552.11. | |
| CDK7-IN-5 | CDK7-IN-5, a CDK7 inhibitor with an IC50 of <100 nM, has anticancer effects. (Extracted from patent WO2015154022A1, Compound 104). Synonyms: 2-Butenamide, 4-(dimethylamino)-N-[4-[[[2-[[[8-(1-methylethyl)-2-[(1-methyl-4-piperidinyl)oxy]pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]methyl]phenyl]amino]methyl]phenyl]-, (2E)-; (E)-4-(dimethylamino)-N-(4-(((2-(((8-isopropyl-2-((1-methylpiperidin-4-yl)oxy)pyrazolo[1,5-a][1,3,5]triazin-4-yl)amino)methyl)phenyl)amino)methyl)phenyl)but-2-enamide. CAS No. 1817006-50-0. Molecular formula: C34H45N9O2. Mole weight: 611.78. | |
| CDK7-IN-6 | CDK7-IN-6 is a potent and selective CDK7 inhibitor (IC50 ≤100 nM) that can be used in cancer research. CDK7-IN-6 shows >200-fold selectivity for CDK7 over CDK1, CDK2, and CDK5. (Extracted from patent WO2019197549 A1, compound 210). Synonyms: 1H-Pyrazole-3-methanol, 1-[2-[[[2-(4-amino-1-piperidinyl)-8-(1-methylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]methyl]-3-chlorophenyl]-α,α-dimethyl-. CAS No. 2378710-04-2. Molecular formula: C26H34ClN9O. Mole weight: 524.06. | |
| CDK7-IN-7 | CDK7-IN-7 is a potent and selective inhibitor of CDK7 kinase with an IC50 of <50 nM. (Patent CN112661745A, compound T-01). Synonyms: methyl (S)-(7-bromo-3-(2-(piperidin-3-ylamino)-5-(trifluoromethyl)pyrimidin-4-yl)-1H-indol-6-yl)carbamate. CAS No. 2640208-01-9. Molecular formula: C20H20BrF3N6O2. Mole weight: 513.31. | |
| CDK8-IN-13 | CDK8-IN-13 is a potent, selective and orally active CDK8 inhibitor with an IC 50 value of 51.9 nM. CDK8-IN-13 induces Apoptosis. CDK8-IN-13 decreases the expression of p-STAT1 S727 and p-STAT5 S726. CDK8-IN-13 shows antitumor activity [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 918523-75-8. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-149974. | |
| CDK8-IN-4 | CDK8-IN-4 is a CDK8 inhibitor with an IC50 of 0.2 nM. (Extracted from patent WO2014090692A1, compound example 16). Synonyms: (2R)-2-{[5-(1H-Indazol-5-yl)-3-pyridinyl]amino}-2-phenylethanol; (R)-2-((5-(1H-indazol-5-yl)pyridin-3-yl)amino)-2-phenylethan-1-ol; Benzeneethanol, β-[[5-(1H-indazol-5-yl)-3-pyridinyl]amino]-, (βR)-. Grade: ≥97%. CAS No. 1613638-82-6. Molecular formula: C20H18N4O. Mole weight: 330.38. | |
| CDK9/CyclinK, active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| CDK9-IN-1 | Among CDKs, CDK9 is a validated pathological target in HIV infection, inflammation and cardiac hypertrophy; however selective CDK9 inhibitors are still not available. We present a selective inhibitor family of CDK9 based on the 4-phenylamino-6- phenylpyrimidine nucleus. We show a convenient synthetic method to prepare a useful intermediate and its derivatisation resulting in novel compounds. The CDK9 inhibitory activity of the derivatives was measured in specific kinase assay and the CDK inhibitory profile of the best ones (IC50 > 100nM) was determined. The most selective compounds had high selectivity over CDK1, 2, 3, 5, 6, 7 and showed at least one order of magnitude higher inhibitory activity over CDK4 inhibition. The most selective molecules were examined in cytotoxicity assays and their ability to inhibit HIV-1 replication was determined in cellular assays. Synonyms: CDK9-IN-1; CDK9 IN 1. Grade: >98%. CAS No. 1415559-43-1. Molecular formula: C26H21N5O4S. Mole weight: 499.54. | |
| CDK9-IN-10 | CDK9-IN-10 is a potent CDK9 inhibitor and the ligand for PROTAC CDK9 degrader-2. Synonyms: 7-benzyloxy-5,8-dihydroxyflavone; 4H-1-Benzopyran-4-one, 5,8-dihydroxy-2-phenyl-7-(phenylmethoxy)-; 7-(Benzyloxy)-5,8-dihydroxy-2-phenyl-4H-chromen-4-one. Grade: ≥95%. CAS No. 3542-63-0. Molecular formula: C22H16O5. Mole weight: 360.36. | |
| CDK9-IN-11 | CDK9-IN-11 is a potent CDK9 inhibitor and ligand of PROTAC CDK9 Degrader-1. Synonyms: 2-Methyl-2-propanyl 5-cyclobutyl-3-{[(4-hydroxyphenyl)acetyl]amino}-1H-pyrazole-1-carboxylate; 1H-Pyrazole-1-carboxylic acid, 5-cyclobutyl-3-[[2-(4-hydroxyphenyl)acetyl]amino]-, 1,1-dimethylethyl ester. Molecular formula: C20H25N3O4. Mole weight: 371.43. | |
| CDK9-IN-12 | CDK9-IN-12 shows the optimal inhibitory activity of CDK9 with an IC50 of 5.41 nM. Synonyms: Benzeneethanol, β-[[6-chloro-5-(3-methyl-1H-indazol-5-yl)-3-pyridinyl]amino]-, (βR)-. CAS No. 1942843-54-0. Molecular formula: C21H19ClN4O. Mole weight: 378.85. | |
| CDK9-IN-14 | CDK9-IN-14 is a potent and selective CDK9 inhibitor with IC 50 of 6.92 nM. CDK9-IN-14 has a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and has a good selectivity and a low toxicity and few side effects [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2650640-17-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-143585. | |
| CDK9-IN-2 | CDK9-IN-2 is a novel cyclin-dependent kinase 9(CDK9) inhibitor. Synonyms: CDK9 Inhibitor II; CDK9 Inhibitor 2; CDK9-In-2; CDK9-IN2. Grade: >98%. CAS No. 1263369-28-3. Molecular formula: C23H25ClFN5. Mole weight: 425.93. | |
| CDK9-IN-28 | CDK9-IN-28 is a CDK9-targeting ATTEC (Autophagosome-tethering compound). CDK9-IN-28, an effective CDK9 inhibitor, can be used as a PROTAC target protein ligand for PROTAC synthesis and has shown strong anti-proliferative activity in solid tumors. This indicates that CDK9-IN-28 has the ability to degrade specific proteins through the autophagy pathway, which is consistent with the characteristics of ATTEC technology. Synonyms: 4-Piperidinecarboxamide, N-[5-[[[5-(1,1-dimethylethyl)-2-oxazolyl]methyl]thio]-2-thiazolyl]-1-[5-[(7-hydroxy-4-methyl-2-oxo-2H-1-benzopyran-5-yl)oxy]pentyl]-; N-(5-(((5-(tert-Butyl)oxazol-2-yl)methyl)thio)thiazol-2-yl)-1-(5-((7-hydroxy-4-methyl-2-oxo-2H-chromen-5-yl)oxy)pentyl)piperidine-4-carboxamide; CDK3-LC3B-10. Grade: ≥95%. CAS No. 3020773-81-0. Molecular formula: C32H40N4O6S2. Mole weight: 640.81. | |
| CDK9-IN-30 | CDK9-IN-30 is a CDK9 inhibitor that inhibits HIV-1 viral replication [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 748146-89-6. Pack Sizes: 5 mg; 10 mg. Product ID: HY-147131. | |
| CDK9-IN-34 | CDK9-IN-34 (Compound 1b) is an inhibitor for CDK9 with an IC 50 of 0.25 μM. CDK9-IN-34 exhibits cytotoxicity to cancer cell HCT116, MCF7 and K652 with IC 50 of 1.43, 3.01 and 50.27 μM, respectively. CDK9-IN-34 exhibits antiviral activity against coronavirus 229E with an IC 50 of 145.92 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 252725-86-3. Pack Sizes: 5 mg; 10 mg; 25 mg. Product ID: HY-164619. | |
| CDK9-IN-6 | CDK9-IN-6, one of the CDK9 inhibitors, probably have potential activity in influencing cell cycle of T-type cells. Uses: Cdk9-in-6 is one of the cdk9 inhibitors that probably have potential activity in influencing cell cycle of t-type cells. Synonyms: CDK9-IN-6; SCHEMBL12466375; SCHEMBL15378321; SCHEMBL15378323; CS-4615; CS 4615; CS4615. Grade: 98%. CAS No. 1391855-95-0. Molecular formula: C27H37ClN6O2. Mole weight: 513.08. | |
| CDK9-IN-7 | CDK9-IN-7 is a highly selective and orally active CDK9/cyclin T inhibitor (IC50 = 11 nM), which exhibits more potent over other CDKs (CDK4/cyclinD: 148 nM; CDK6/cyclinD: 145 nM). CDK9-IN-7 induces NSCLC cell apoptosis, arrests the cell cycle in the G2 phase, and suppresses the stemness properties of NSCLC. Synonyms: CDK9-IN-7; 2369981-71-3; CHEMBL4548580; 7-cyclopentyl-2-[4-(8-isothiocyanatooctanoylamino)anilino]-N,N-dimethylpyrrolo[2,3-d]pyrimidine-6-carboxamideBDBM50519560. Grade: ≥99%. CAS No. 2369981-71-3. Molecular formula: C29H37N7O2S. Mole weight: 547.71. | |
| CDK9-IN-8 | CDK9-IN-8 is a highly potent and selective inhibitor of CDK9 with an IC50 of 12 nM. Synonyms: N-(4-{[7-Cyclopentyl-6-(dimethylcarbamoyl)-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino}phenyl)-N'-(4-fluorophenyl)-1,1-cyclopropanedicarboxamide; 1,1-Cyclopropanedicarboxamide, N-[4-[[7-cyclopentyl-6-[(dimethylamino)carbonyl]-7H-pyrrolo[2,3-d]pyrimidin-2-yl]amino]phenyl]-N'-(4-fluorophenyl)-. Grade: ≥95%. CAS No. 2105956-51-0. Molecular formula: C31H32FN7O3. Mole weight: 569.63. | |
| CDK9-IN-9 | CDK9-IN-9 is a potent and selective CDK9 inhibitor (IC50 = 1.8 nM) with anticancer activity. It is also a CDK2 inhibitor with an IC50 of 155 nM. Synonyms: 3,20-Difluoro-10-[(S-methylsulfonimidoyl)methyl]-13-oxa-5,7,18,25-tetraazatetracyclo[17.3.1.12,6.18,12]pentacosa-1(23),2(25),3,5,8(24),9,11,19,21-nonaene; 13-Oxa-5,7,18,25-tetraazatetracyclo[17.3.1.12,6.18,12]pentacosa-1(23),2,4,6(25),8,10,12(24),19,21-nonaene, 3,20-difluoro-10-[(S-methylsulfonimidoyl)methyl]-. Grade: ≥98%. CAS No. 2246956-84-1. Molecular formula: C22H23F2N5O2S. Mole weight: 459.51. | |
| CDK9 inhibitor HH1 | CDK9 inhibitor HH1 is a novel potent, highly selective CDK9 inhibitor that inhibits the transcription of CDK and can be used in research of cancer. Synonyms: (4-amino-2-(isopropylamino)thiazol-5-yl)(phenyl)methanone. Grade: >95.0%. CAS No. 204188-41-0. Molecular formula: C13H15N3OS. Mole weight: 261.34. | |
| Cdk9 Inhibitor II | Cdk9 Inhibitor II. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Cdk9 Inhibitor II, CHEMBL1823556, 4-(3,5-Diamino-1H-pyrazol-4-ylazo)-phenol, 4-[(E)-(3,5-Diamino-1h-Pyrazol-4-Yl)diazenyl]phenol, 140651-18-9, F18, 2clx, 3tn8, SureCN3310182, SureCN12589685, UNII-ZG0O47K626, CAN508, CHEMBL215205, CTK8F0280, CAN-508, MolPort-009-019-369, HMS3229D19, DNC006929, IN1367, NSC741614. Product Category: Heterocyclic Organic Compound. Appearance: crystalline solid. CAS No. 140651-18-9. Molecular formula: C9H10N6O. Mole weight: 218.2. Purity: ≥95%. IUPACName: 4-[(3,5-diamino-1H-pyrazol-4-yl)hydrazinylidene]cyclohexa-2,5-dien-1-one. Canonical SMILES: C1=CC(=O)C=CC1=NNC2=C(NN=C2N)N. Product ID: ACM140651189. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Cdk9 Inhibitor II - CAS 140651-18-9 | The Cdk9 Inhibitor II, also referenced under CAS 140651-18-9, controls the biological activity of Cdk9. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| Cdk/CKI Inhibitor, (R)-DRF053 - CAS 1186647-87-9 | The Cdk/CKI Inhibitor, (R)-DRF053, also referenced under CAS 1186647-87-9, controls the biological activity of Cdk/CKI. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK/CRK Inhibitor | CDK/CRK inhibitor is an inhibitor of cyclin-dependent kinases (CDK) and CDK-related kinases (CRK) with IC50 values ranging from 9-839 nM. It is also a potent, selective & ATP-competitive inhibitor of CDKs. CDK/CRK inhibitor exhibits less than 20% inhibition of 60 non-CDK/CRK kinases at 1 μM. Synonyms: Cdk7 Inhibitor IV; Cyclin-dependent kinase 7 Inhibitor IV; Cyclin-dependent kinase/CDK-related kinase Inhibitor; RGB-286147; RGB 286147. Grade: ≥98%. CAS No. 784211-09-2. Molecular formula: C23H22Cl2N4O3. Mole weight: 473.4. | |
| Cdk/Crk Inhibitor - CAS 784211-09-2 | The Cdk/Crk Inhibitor, also referenced under CAS 784211-09-2, controls the biological activity of Cdk/Crk. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications. Group: Fluorescence/luminescence spectroscopy. | |
| CDK/HDAC-IN-1 | CDK/HDAC-IN-1 has remarkable inhibitory activity against CDK2/4/6 and HDAC6 with IC50s of 60.9±2.9, 276±22.3, 27.2±4.2, and 128.6±0.4 nM, respectively. Synonyms: (E)-N-hydroxy-4-(((2'-hydroxy-1'H,3H-[2,3'-biindol]-3-ylidene)amino)oxy)butanamide. Molecular formula: C20H18N4O4. Mole weight: 378.38. | |
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