A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Antimigraine. Group: Biochemicals. Alternative Names: 1-(Diphenylmethyl)-4-[3-(2-phenyl-1,3-dioxolan-2-yl)propyl]piperazine; FI-6026. Grades: Highly Purified. CAS No. 84625-59-2. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
DOTATATE
DOTATATE is a DOTA-conjugated peptide. DOTATATE can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-88-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-106244.
DOTATATE
DOTATATE is a radiolabeled somatostatin analog used in medical imaging and therapy for neuroendocrine tumors (NETs). DOTATATE is a peptide derivative that binds selectively to somatostatin receptors (mainly subtype 2), which are overexpressed on the surface of neuroendocrine tumor cells. This allows for specific targeting of these tumors. Synonyms: L-Threonine, N-[2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide; L-Threonine, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide; DOTA-octreotate; DOTA-TATE; DOTA-[Tyr3]-Octreotide Acid; DOTA-(Tyr3)-octreotate. Grade: ≥95%. CAS No. 177943-88-3. Molecular formula: C65H90N14O19S2. Mole weight: 1435.63.
DOTATATE acetate
DOTATATE acetate is a DOTA-conjugated peptide. DOTATATE acetate can be labelled with radionuclides for positron emission tomography (PET) imaging and peptide receptor radionuclide research (PRRT) [1] [2] [3] [4]. DOTATATE (acetate) can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs). Uses: Scientific research. Group: Peptides. CAS No. 177943-89-4. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-106244A.
DOTATATE acetate
DOTATATE acetate is a radiolabeled somatostatin analog used in medical imaging and therapy for neuroendocrine tumors (NETs). DOTATATE acetate is a peptide derivative that binds selectively to somatostatin receptors (mainly subtype 2), which are overexpressed on the surface of neuroendocrine tumor cells. This allows for specific targeting of these tumors. Synonyms: L-Threonine, N-[[4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododec-1-yl]acetyl]-D-phenylalanyl-L-cysteinyl-L-tyrosyl-D-tryptophyl-L-lysyl-L-threonyl-L-cysteinyl-, cyclic (2→7)-disulfide, acetate (salt) (1:x); DOTA-(Tyr3,Thr8)-Octreotide acetate; DOTA-[Tyr3] Octreotide Acid (Octreotate) acetate; DOTA-octreotate acetate; DOTA-[Tyr3]-Octreotide Acid acetate. Grade: 98%. CAS No. 177943-89-4. Molecular formula: C65H90N14O19S2.xC2H4O2. Mole weight: 1435.63 (free base).
DOTA (TETRAXETAN)
Tetraxetan is a biochemical reagent that can be used as a biological material or organic compound for life science related research. CAS No. 60239-18-1. Product ID: API60239181. SMILES: C1CN(CCN(CCN(CCN1CC(=O)O)CC(=O)O)CC(=O)O)CC(=O)O. Appearance: white powder. Category: Active Pharmaceutical Ingredients.
DOTA-tris(tBu)ester NHS ester
DOTA-tris(tBu)ester NHS ester is a derivative of DOTA for the labeling of peptides and antibodies [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 819869-77-7. Pack Sizes: 25 mg; 50 mg; 100 mg; 250 mg. Product ID: HY-131326.
DOTA-tris(tert-butyl ester)
It is the PDC linker targeting moietie of peptide drug conjugates (PDCs). Synonyms: Tri-tert-butyl 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetate; DOTA tri(tert-butyl) ester; DOTA(OBu-t)3; Tri-tert-Bu-DOTA; 2-(4,7,10-Tris(2-(tert-butoxy)-2-oxoethyl)-1,4,7,10-tetraazacyclododecan-1-yl)acetic acid; DOTA(OtBu); 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7-tris(1,1-dimethylethyl) ester; 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, tris(1,1-dimethylethyl) ester; 1,4,7,10-Tetraazacyclododecane-1,4,7-tris-tert-butyl acetate-10-acetic acid. Grade: 95%. CAS No. 137076-54-1. Molecular formula: C28H52N4O8. Mole weight: 572.73.
DOTA-tri(t-butyl ester)
DOTA-tri(t-butyl ester) can be used in the synthesis of generations 3 (G3) nanoglobular magnetic resonance imaging (MRI) contrast agents for MR angiography and tumor angiogenesis imaging [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 137076-54-1. Pack Sizes: 10 mM * 1 mL; 100 mg; 500 mg. Product ID: HY-W034551.
Dotetracontane
analytical standard. Group: Fuels and hydrocarbons.
Dothiepin
A tricyclic antidepressant. Group: Biochemicals. Alternative Names: 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-. Grades: Highly Purified. CAS No. 113-53-1. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Dothiepin
Dothiepin (Dosulepin; Dothep) is an antidepressant agent with sedative/anxiolytic activity. Dothiepin is an inhibitor preferring of noradrenaline uptake than serotonin uptake. Dothiepin facilitates noradrenergic neurotransmission via inhibiting the neuronal uptake. Dothiepin is also an antagonist of histamine H1-receptor without cardiotoxicity. Dothiepin exhibits significant analgesic activity in psychogenic facial pain, idiopathic fibromyalgia syndrome or rheumatoid arthritis [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dosulepin; Dothep. CAS No. 113-53-1. Pack Sizes: 1 mg. Product ID: HY-12394.
Dothiepin-d3
Labeled Dothiepin. A tricyclic antidepressant. Group: Biochemicals. Alternative Names: 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N-methyl-N-(methyl-d3)-. Grades: Highly Purified. CAS No. 136765-31-6. Pack Sizes: 1mg. US Biological Life Sciences.
Worldwide
Dothiepin-[d3]
Dothiepin-[d3] is the labelled analogue of Dothiepin, which is a tricyclic antidepressant. Synonyms: Dothiepin D3; 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N-methyl-N-(methyl-d3)-1-propanamine; N,N-(Dimethyl-d3)-dibenzo[b,e]thiepin-11(6H), γ-propylamine-d3; Dosulepin-d3; Dosulepine-d3; Dothep-d3; Prothiaden-d3; Prothiadene-d3; cis-dothiepin-d3; Z-dothiepin-d3. Grade: ≥95%; ≥98% atom D. CAS No. 136765-31-6. Molecular formula: C19H18D3NS. Mole weight: 298.46.
Dothiepin-[d3] Maleate
Dothiepin-[d3] Maleate is the labelled analogue of dothiepin. Dothiepin is a tricyclic antidepressant which is used in the treatment of depression. Synonyms: Dothiepin-d3 Maleate. Grade: 95% by HPLC; 98% atom D. Molecular formula: C23H22D3NO4S. Mole weight: 414.53.
Dothiepin-[d6] HCl is an isotope labelled form of Dothiepin hydrochloride. Dosulepin is a tricyclic antidepressant which is used in the treatment of depression. Synonyms: Dosulepin HCl; 3-Dibenzo[b,e]thiepin-11(6H)-ylidene-N,N-dimethyl-1-propanamine HCl. Grade: 95%+ by HPLC; 99% atom D. CAS No. 1276545-35-7. Molecular formula: C19H16D6ClNS. Mole weight: 337.94.
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Synonyms: 1,2-Di-O-Octadecenyl-3-Trimethylammonium Propane; Trimethyl[2,3-(dioleyloxy)propyl]ammonium Chloride; N-(1-(2,3-dioleyloxy)propyl)-N,N,N-trimethylammonium. Grade: >98%. CAS No. 104872-42-6. Molecular formula: C42H84ClNO2. Mole weight: 670.57.
DOTMA
DOTMA is a cationic lipid that has been used as a non-viral vector for gene therapy. DOTMA is used as a component of liposomes to encapsulate siRNA, microRNA, and oligonucleotides and for in vitro gene transfection. DOTMA promotes effective interaction between liposomes and cell membranes by inducing positive charge on the liposomes. DOTMA showed good gene transfection effect both in vitro and in vivo [1] [2] [3] [4] [5]. Uses: Scientific research. Group: Biochemical assay reagents. CAS No. 104872-42-6. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-139200.
DOTMA
DOTMA is one of the first cationic lipid used for gene transfection. DOTMA is an effective transfection agent in vitro and in vivo. DOTMA carries a positive charge on the surface of liposomes which condenses anionic nucleic acids and promotes efficient interactions between the cell membrane and the liposome. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DOTMA; 1,2-di-O-octadecenyl-3-trimethylammonium propane. Product Category: Others. Appearance: Solid powder. CAS No. 104872-42-6. Molecular formula: C42H84ClNO2. Mole weight: 670.59. Purity: >98%. IUPACName: N,N,N-trimethyl-2,3-bis(((Z)-octadec-9-en-1-yl)oxy)propan-1-aminium chloride. Canonical SMILES: CCCCCCCC/C=C\CCCCCCCCOCC(OCCCCCCCC/C=C\CCCCCCCC)C[N+](C)(C)C.[Cl-]. Product ID: ACM104872426. Alfa Chemistry ISO 9001:2015 Certified.
Dotriacolide
It is produced by the strain of Micromonosporaechinospora MG199-fF35. It has inhibitory effects on β-lactamase, DNA enzyme and Topoisomerase I. Synonyms: Oxacyclodotriacont-3-en-2-one,16,18,30-tris(sulfooxy)-32-(8-(sulfooxy)nonyl)-; (Z)-32-oxo-2-(8-(sulfooxy)nonyl)oxacyclodotriacont-30-ene-4,16,18-triyl tris(hydrogen sulfate). CAS No. 80994-06-5. Molecular formula: C40H76O18S4. Mole weight: 973.28.
Dotriacontane
5g Pack Size. Group: Building Blocks, Organics. Formula: C32H66. CAS No. 544-85-4. Prepack ID 68080396-5g. Molecular Weight 450.87. See USA prepack pricing.
Dotriacontane
Dotriacontane is an alkane substance that can be absorbed and metabolized by photosynthetic organisms. It can be labeled with 14 C and used for carbon tracing [1]. Uses: Scientific research. Group: Natural products. CAS No. 544-85-4. Pack Sizes: 5 g; 10 g. Product ID: HY-N9600.
Dotriacontane
analytical standard. Group: Fuels and hydrocarbons.
Dotriacontane-[d66]
Dotriacontane-[d66] is the labelled analogue of Dotriacontane. Dotriacontane, also known as N-dotriacontane or bicetyl, belongs to the class of organic compounds known as alkanes. Outside of the human body, can be found in coconut, garden tomato (var. ), papaya, and tea. This makes a potential biomarker for the consumption of these food products. Synonyms: N-Dotriacontane-d66; Dotriacontane-d66; Bicetyl-d66; NSC 6361-d66; Lacceran-d66. Grade: 98%; 98% atom D. CAS No. 62369-68-0. Molecular formula: C32D66. Mole weight: 517.27.
Double-pass AAO Template 1.2 cm(D: 100nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-29. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D: 200nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-24. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D: 300nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-21. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D:40-60nm,hole depth: 40-70 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-20. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(D: 50nm,hole depth: 50 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-53. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 1.2 cm(HD:400nm)
Double-pass AAO Template 1.2 cm(HD:400nm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-50. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template 2.5 cm(D: 100nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-61. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 200nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-6. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 300nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-25. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 400nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-9. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template 2.5 cm(D: 50nm,hole depth: 60 μm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-32. Alfa Chemistry ISO 9001:2015 Certified.
Double-pass AAO Template(HD:20-40nm D:1.2cm)
Double-pass AAO Template(HD:20-40nm D:1.2cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-47. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template(HD:20-40nm D:2.5cm)
Double-pass AAO Template(HD:20-40nm D:2.5cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-15. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template(HD:60-80nm D:1.2cm)
Double-pass AAO Template(HD:60-80nm D:1.2cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323-14. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
Double-pass AAO Template(HD:60-80nm D:2.5cm)
Double-pass AAO Template(HD:60-80nm D:2.5cm). Uses: Designed for use in research and industrial production. Product Category: Inorganic Nanomaterials. CAS No. 11092-32-3. Product ID: ACM11092323. Alfa Chemistry ISO 9001:2015 Certified. Categories: ALUMINUM OXIDE.
double-stranded RNA adenine deaminase
This eukaryotic enzyme is involved in RNA editing. It destabilizes double-stranded RNA through conversion of adenosine to inosine. Inositol hexakisphosphate is required for activity. Group: Enzymes. Synonyms: ADAR; double-stranded RNA adenosine deaminase; dsRAD; dsRNA adenosine deaminase; DRADA1; double-stranded RNA-specific adenosine deaminase. Enzyme Commission Number: EC 3.5.4.37. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4565; double-stranded RNA adenine deaminase; EC 3.5.4.37; ADAR; double-stranded RNA adenosine deaminase; dsRAD; dsRNA adenosine deaminase; DRADA1; double-stranded RNA-specific adenosine deaminase. Cat No: EXWM-4565.
double-stranded uracil-DNA glycosylase
No activity on DNA containing a T/G mispair or single-stranded DNA containing either a site-specific uracil or 3,N4-ethenocytosine residue, significant role for double-stranded uracil-DNA glycosylase in mutation avoidance in non-dividing E. coli. Uracil-DNA glycosylases are widespread enzymes that are found in all living organisms. Uracil-DNA glycosylase (EC 3.2.2.27) and EC 3.2.2.28 form a central part of the DNA-repair machinery since they initiate the DNA base-excision repair pathway by hydrolysing the N-glycosidic bond between uracil and the deoxyribose sugar thereby catalysing the removal of mis-incorporated uracil from DNA. Group: Enzymes. Synonyms: Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous). Enzyme Commission Number: EC 3.2.2.28. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3982; double-stranded uracil-DNA glycosylase; EC 3.2.2.28; Mug; double-strand uracil-DNA glycosylase; Dug; dsUDG; double-stranded DNA specific UDG; dsDNA specific UDG; UdgB (ambiguous); G:T/U mismatch-specific DNA glycosylase; UDG (ambiguous). Cat No: EXWM-3982.
Double-wall carbon nanotubes
Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSol
Carbon black oil appears as a dark colored liquid with a petroleum-like odor. Less dense than water and insoluble in water. Vapors heavier than air.;Carbon, activated is a black grains that have been treated to improve absorptive ability. May heat spontaneously if not properly cooled after manufacture.;Carbon, animal or vegetable origin appears as a black powder or granular mixed with a tar or starch and water binder pressed into regular lumps or briquettes. Heats slowly and ignites in air especially if wet.;Graphite (natural) appears as a mineral form of the element carbon. Hexagonal crystals or thin leaf-like layers. Steel-gray to black with a metallic luster and a greasy feel. An electrical conductor. Used for high-temperature crucibles, as a lubricant and in "lead" pencils.;DryPowder; DryPowder, Liquid; DryPowder, PelletsLargeCrystals; DryPowder, PelletsLargeCrystals, WetSolid, OtherSolid, Liquid; DryPowder, WetSolid, Liquid; Liquid; OtherSolid; OtherSolid, GasVapor, Liquid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid, Liquid; WetSolid; WetSolid, Liquid;OtherSolid; PelletsLargeCrystals;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSolid;DryPowder; DryPowder, OtherSolid; DryPowder, PelletsLargeCrystals; DryPowder, WetSolid; Liquid; OtherSolid; PelletsLargeCrystals; PelletsLargeCrystals, OtherSolid; WetSo
Double-walled Carbon Nanotubes
Double-walled Carbon Nanotubes. Group: Nanotubes other nano materials double wall cnt. CAS No. 308068-56-6. Product ID: Carbon. Molecular formula: 12.01. C. > 98wt%.
Double-Walled Carbon Nanotubes (DWNTs) 2-4nm. Uses: Double-walled carbon nanotubes (cnts) can be used in various fields including additives in polymers, catalysts, electron field emitters for cathode ray lighting elements, flat panel display, gas-discharge tubes in telecom networks, electromagnetic-wave absorption and shielding, energy conversion, lithium-battery anodes, hydrogen storage, nanotube composites (by filling or coating); nanoprobes for stm, afm, and efm tips, nanolithography, nanoelectrodes, drug delivery sensors, reinforcements in composites, supercapacitor. Additional or Alternative Names: Double-Walled Carbon Nanotubes, Double Wall Carbon Nanotube, Carbon Nanotube, DWNT, DWCNT, CNT. Product Category: Carbon Nanotubes. Appearance: Color: Black. CAS No. 1333-86-4. Purity: >60%. Density: True density: ~2.1 g/cm³. Product ID: ACM1333864-32. Alfa Chemistry ISO 9001:2015 Certified.
DOV-216,303 (Free Base) is a potent triple serotonin , norepinephrine , and dopamine reuptake inhibitor, with IC 50 values of 14 nM, 20 nM and 78 nM for hSERT, hNET and hDAT, respectively [1]. Has antidepressant-like effects and increases monoamine release in the prefrontal cortex of olfactory bulbectomized (OBX) rats [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 66504-40-3. Pack Sizes: 5 mg; 10 mg. Product ID: HY-18332C.
DOV-216,303 Free Base
DOV-216,303 is a reuptake inhibitor, inhibiting the reuptake of norepinephrine (NE), serotonin (5-HT), and dopamine (DA), the three neurotransmitters most closely linked to major depressive disorder. Synonyms: 1-(3,4-Dichloro-phenyl)-3-aza-bicyclo[3.1.0]hexane; DOV-216,303. Grade: 98%. CAS No. 66504-40-3. Molecular formula: C11H11Cl2N. Mole weight: 228.12.
Dovitinib
Dovitinib (TKI258) potently inhibited FLT3, c-KIT, FGFR, VEGFR1/2/3, PDGFRß and CSF-1R with IC50 values of 1, 2, 5, 10, 8, 27, 36 nM respectively. Dovitinib selectively blocked the growth of wild-type (WT) or activated mutant FGFR3-transformed B9 cells and human myeloma cell lines. Dovitinib was an effective treatment in a xenograft mouse model of FGFR3 multiple myeloma. Synonyms: Dovitinib, TKI258; TKI 258; TKI-258; CHIR 265; CHIR265; CHIR-265; RAF-265; RAF 265; RAF265. Grade: > 95%. CAS No. 405169-16-6. Molecular formula: C21H21FN6O. Mole weight: 392.429.
Dovitinib
Dovitinib (CHIR-258) is an orally active, potent multi-targeted tyrosine kinase (RTK) inhibitor with IC 50 s of 1, 2, 36, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , CSF-1R , FGFR1/FGFR3 , VEGFR1/VEGFR2/VEGFR3 and PDGFRα/PDGFRβ , respectively. Dovitinib has potent antitumor activity [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258; TKI258. CAS No. 405169-16-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50905.
Dovitinib-[d8]
Dovitinib-[d8] is the labelled analogue of Dovitinib. Dovitinib is a receptor tyrosine kinase (RTK) inhibitor that exhibits an suppressive effect of tumor growth. Synonyms: Dovitinib-D8; 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone-d8; 4-Amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]quinolin-2(1H)-one-d8; GFKI 258-d8; TKI 258-d8. Grade: >95%. CAS No. 1246819-84-0. Molecular formula: C21H13D8FN6O. Mole weight: 400.48.
Dovitinib Dilactic Acid
Dovitinib is a multitargeted RTK inhibitor, mostly for class III (FLT3/c-Kit) with IC50 of 1 nM/2 nM, also potent to class IV (FGFR1/3) and class V (VEGFR1-4) RTKs with IC50 of 8-13 nM, less potent to InsR, EGFR, c-Met, EphA2, Tie2, IGF-1R and HER2 in cell-free assays. Synonyms: Dovitinib Dilactic acid; TKI258 Dilactic acid; CHIR-258; CHIR 258; CHIR258; TKI258; TKI 258; TKI-258. Grade: >98%. CAS No. 852433-84-2. Molecular formula: C27H33FN6O7. Mole weight: 572.59.
Dovitinib lactate
Dovitinib, also referred as CHIR-258 or TKI258, is a potent receptor tyrosine kinase inhibitor (TKI) that selectively targets VEGFR, PDGFR, FGFR, CSF1R, c-KIT, RET, TrKA, and FLT3, and additionally targets FGFR (IC50 = 5 nM). Synonyms: 4-amino-5-fluoro-3-[5-(4-methylpiperazin-1-yl)-1,3-dihydrobenzimidazol-2-ylidene]quinolin-2-one; 2-hydroxypropanoic acid; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate; Dovitinib(lactate); 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxy; CTK8B6779. CAS No. 692737-80-7. Molecular formula: C24H27FN6O4. Mole weight: 482.51.
Dovitinib lactate
Dovitinib lactate (TKI258 lactate) is a multi-targeted tyrosine kinase inhibitor with IC 50 s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3 , c-Kit , FGFR1/3 , VEGFR1/2/3 and PDGFRα/β , respectively [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: CHIR-258 lactate; TKI-258 lactate. CAS No. 692737-80-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10207.
Dovitinib Lactate
Dovitinib is used in treating melanoma. Group: Biochemicals. Alternative Names: 4-Amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone 2-Hydroxypropanoic Acid; CHIR 258; TKI 258. Grades: Highly Purified. CAS No. 692737-80-7. Pack Sizes: 10mg. US Biological Life Sciences.
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Dovitinib Lactate Hydrate
Dovitinib lactate hydrate is a multi-targeted tyrosine kinase inhibitor with IC50s of 1, 2, 8/9, 10/13/8, 27/210 nM for FLT3, c-Kit, FGFR1/3, VEGFR1/2/3 and PDGFRα/β, respectively. Synonyms: TKI258 lactate hydrate; CHIR-258 lactate hydrate; 4-Amino-5-fluoro-3-(6-(4-methylpiperazin-1-yl)-1H-benzo[d]imidazol-2-yl)quinolin-2(1H)-one 2-hydroxypropanoate hydrate; Propanoic acid, 2-hydroxy-, compd. with 4-amino-5-fluoro-3-[6-(4-methyl-1-piperazinyl)-1H-benzimidazol-2-yl]-2(1H)-quinolinone, hydrate (1:1:1). Grade: >98%. CAS No. 915769-50-5. Molecular formula: C24H29FN6O5. Mole weight: 500.52.
Dov-Val-Dil-OH
Dov-Val-Dil-OH is an intermediate of dolastoxin, a cytotoxic liner peptide produced by Dolabbella auriclaria which exhibits potent antitumor activity. Synonyms: (3R,4S,5S)-4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoic acid; (3R,4S,5S)-3-Methoxy-4-[methyl(N,N-dimethyl-L-Val-L-Val-)amino]-5-methylheptanoic acid. CAS No. 133120-89-5. Molecular formula: C22H43N3O5. Mole weight: 429.59.
Dov-Val-Dil-OH TFA
Dov-Val-Dil-OH is a useful chemical intermediate for synthesis of auristatin-related compounds, such as Monomethyl auristatin E (MMAE), Auristatins are antimitotic agents which inhibits cell division by blocking the polymerisation of tubulin. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Dov-Val-Dil-OH TFA; Dov-Val-Dil-OH; Dov-Val-Dil-OH; dimethylVal-Val-Dil-COOH. Product Category: Others. Appearance: Solid powder. CAS No. 133120-90-8. Molecular formula: C24H44F3N3O7. Mole weight: 543.63. Purity: >98%. IUPACName: (3R,4S,5S)-4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoic acid trifluoroacetic acid. Canonical SMILES: CC[C@H](C)[C@H](N(C)C([C@@H](NC([C@@H](N(C)C)C(C)C)=O)C(C)C)=O)[C@H](OC)CC(O)=O.O=C(O)C(F)(F)F. Product ID: ACM133120908. Alfa Chemistry ISO 9001:2015 Certified.