A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Dy-560 NHS ester. Uses: Designed for use in research and industrial production. Additional or Alternative Names: 2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-[[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]sulfamoyl]benzenesulfonate. Product Category: Rhodamine Fluorophores. CAS No. 178623-13-7. Molecular formula: C37H44N4O10S2. Mole weight: 768.9. Purity: 0.98. IUPACName: 2-[3-(diethylamino)-6-diethylazaniumylidenexanthen-9-yl]-5-[[6-(2,5-dioxopyrrolidin-1-yl)oxy-6-oxohexyl]sulfamoyl]benzenesulfonate. Canonical SMILES: CCN(CC)C1=CC2=C(C=C1)C(=C3C=CC(=[N+](CC)CC)C=C3O2)C4=C(C=C(C=C4)S(=O)(=O)NCCCCCC(=O)ON5C(=O)CCC5=O)S(=O)(=O)[O-. Product ID: ACM178623137-1. Alfa Chemistry ISO 9001:2015 Certified.
Dy-615 NHS ester
for fluorescence. Group: Fluorescence/luminescence spectroscopy.
Dybowskin-1CDYa
Dybowskin-1CDYa is an antimicrobial peptide produced by Rana dybowskii. It has activity against the Gram-positive bacterium S.aureus (MIC=6 μM) and the Gram-negative bacterium E.coli (MIC=3 μM). Dybowskin-1CDYa lacks hemolytic activity against human erythrocytes.
Dybowskin-2
Dybowskin-2 has antibacterial and antifungal activity. The source of Dybowskin-2 is Rana dybowskii. Grade: >97% by HPLC.
Dybowskin-2CDYa
Dybowskin-2CDYa is an antimicrobial peptide. It has activity against the Gram-positive bacterium S.aureus (MIC=6 μM) and the Gram-negative bacterium E.coli (MIC=3 μM). Dybowskin-2CDYa lacks hemolytic activity against human erythrocytes. Grade: >96% by HPLC.
Dybowskin-2CDYb
Dybowskin-2CDYb is an antimicrobial peptide from Rana dybowskii.
Dybowskin-3
Dybowskin-3 is active against S. aureus, B. cereus, and S. lactis (MIC 37.5 uM), C. albicans (MIC 50 uM), and cancer cells MCF7 cells and Hela cells (IC50 50 uM). Synonyms: Brevinin-2DYc.
Dybowskin-4
Dybowskin-4 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. Grade: >96% by HPLC.
Dybowskin-5
Dybowskin-5 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii. Grade: >96% by HPLC.
Dybowskin-6
Dybowskin-6 has antibacterial and antifungal activity. Dybowskin-4 was found in Rana dybowskii.
Dyclonine hydrochloride
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local anesthetic that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DYCLONINE;DYCLONINE HCL;DYCLONINE HYDROCHLORIDE;LABOTEST-BB LT00771942;1-(4-BUTOXYPHENYL)-3-(1-PIPERIDINYL)-1-PROPANONE HCL;1-(4-BUTOXYPHENYL)-3-(1-PIPERIDINYL)-1-PROPANONE HYDROCHLORIDE;1-(4-butoxyphenyl)-3-(1-piperidinyl)-1-propanonhydrochloride;4'-butoxy-3-piperidinopropiophenonehydrochloride. Product Category: Inhibitors. Appearance: White Crystalline Solid. CAS No. 536-43-6. Molecular formula: C18H28ClNO2. Mole weight: 325.87. Purity: 0.96. IUPACName: dyclonine hydrochloride. Product ID: ACM536436. Alfa Chemistry ISO 9001:2015 Certified.
Dyclonine hydrochloride
Dyclonine (Dyclocaine) hydrochloride is an orally effective ALDH covalent inhibitor (crosses blood-brain barrier), with an IC 50 of 35 μM for ALDH2 and 76 μM for ALDH3A1. Dyclonine hydrochloride has sensitizing activities for targeted cancer cells and antibacterial. Dyclonine hydrochloride is also a local agent that can suppress or relieve pain. that blocks the transmission of various nerve impulses or stimuli and inhibits the sensation of touch and pain [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Dyclocaine hydrochloride. CAS No. 536-43-6. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g; 10 g. Product ID: HY-B0364A.
Dyclonine, hydrochloride
Dyclonine, hydrochloride. Group: Biochemicals. Alternative Names: 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone hydrochloride; 4'-Butoxy-3-piperidinopropiophenon e hydrochloride; Dyclothane. Grades: Highly Purified. CAS No. 536-43-6. Pack Sizes: 10g, 25g, 50g, 100g, 250g. Molecular Formula: C18H28ClNO2. US Biological Life Sciences.
Worldwide
Dyclonine Hydrochloride
Dyclonine HCl is a hydrochloride salt form of dyclonine which is an oral anaesthetic. Grade: >98%. CAS No. 536-43-6. Molecular formula: C18H27NO2.HCl. Mole weight: 325.87.
Used as a local anesthetic. Group: Biochemicals. Alternative Names: 1-(4-Butoxyphenyl)-3-(1-piperidinyl)-1-propanone, Hydrochloride. Grades: Highly Purified. Pack Sizes: 25g. US Biological Life Sciences.
Worldwide
Dyclonine Impurity 3
Dyclonine Impurity 3. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (E)-1,4-bis(4-butoxyphenyl)but-2-ene-1,4-dione. CAS No. 14146-86-2. Molecular formula: C24H28O4. Mole weight: 380.48. Catalog: APB14146862.
Dydrogesteron
Dydrogesteron. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-8,9,10,11,12,13,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3(2H)-one. CAS No. 152-62-5. Molecular formula: C21H28O2. Mole weight: 312.45. Catalog: APB152625.
Dydrogesterone
Dydrogesterone. Uses: Designed for use in research and industrial production. Additional or Alternative Names: (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one; Dydrogesterone. Product Category: Steroidal Compounds. CAS No. 152-62-5. Molecular formula: C21H28O2. Mole weight: 312.45. Purity: 95%+. IUPACName: (8S,9R,10S,13S,14S,17S)-17-acetyl-10,13-dimethyl-1,2,8,9,11,12,14,15,16,17-decahydrocyclopenta[a]phenanthren-3-one. Canonical SMILES: CC(=O)C1CCC2C1(CCC3C2C=CC4=CC(=O)CCC34C)C. Density: 1.1g/cm³. ECNumber: 205-806-8. Product ID: ACM152625. Alfa Chemistry ISO 9001:2015 Certified.
Dydrogesterone
Dydrogesterone is a potent, orally active progestogen indicated in a wide variety of gynaecological conditions related to progesterone deficiency. Uses: Scientific research. Group: Signaling pathways. CAS No. 152-62-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-B0257A.
Dydrogesterone
Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. Uses: Progestational hormones, synthetic. Synonyms: NSC 92336; NSC92336; NSC-92336. Grade: >98%. CAS No. 152-62-5. Molecular formula: C21H28O2. Mole weight: 312.45.
Dydrogesterone
A synthetic progestin largely used in hormone therapy, on the central nervous system by studying two markers of the neuroendocrine function: the neurosteroid allopregnanolone and the opioid beta.-endorphin. Progestogen. Group: Biochemicals. Alternative Names: (9 β,10α)-Pregna-4,6-diene-3,20-dione; 6-Dehydro-9 β,10α-progesterone; 6-De hydroretroprogester one; 6α-Dehydro-retro-4-pregnene-3,20-dione; Diphaston; Dufaston; Gynorest; Hydrogesterone; Prodel; Retrone. Grades: Highly Purified. CAS No. 152-62-5. Pack Sizes: 10mg, 25mg, 50mg, 100mg. Molecular Formula: C21H28O2, Form: Light Yellow. US Biological Life Sciences.
Worldwide
Dydrogesterone EP Impurity A
An impurity of Dydrogesterone. Dydrogesterone is a steroidal progestin of the retroprogesterone group. It can be used as an effective progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. Synonyms: 9β,10α-Pregna-4,6,8(14)-triene-3,20-dione. Grade: 95%. CAS No. 23035-53-2. Molecular formula: C21H26O2. Mole weight: 310.43.
Dydrogesterone EP Impurity C
An impurity of Dydrogesterone. Dydrogesterone is a steroidal progestin of the retroprogesterone group. It can be used as an effective progestogen for gynaecological conditions related to a wide variety of progesterone deficiencies in pregnant women. Synonyms: 9beta,10alpha,17alpha-Pregna-4,6-diene-3,20-dione; 17α-Dydrogesterone; 17alpha-Dydrogesterone. CAS No. 246038-13-1. Molecular formula: C21H28O2. Mole weight: 312.45.
Dydrogesterone Impurity 19
Dydrogesterone Impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 151478-10-3. Molecular formula: C25H36O4. Mole weight: 400.56. Catalog: APB151478103.
DYE 1602
DYE 1602. Group: Biochemicals. Alternative Names: N, N'-Cyclohexa-2, 5-diene-1, 4-diylidenebis[4- (dibutylamino) -N-[4- (dibutylamino) phenyl]anilinium] bis [hexafluoroantimonate (1-) ] (1: 2) . Grades: Highly Purified. CAS No. 5496-71-9. Pack Sizes: 5g, 10g, 25g, 50g, 100g. Molecular Formula: C62H94N6·2F6Sb. US Biological Life Sciences.
Worldwide
dye decolorizing peroxidase
Heme proteins with proximal histidine secreted by basidiomycetous fungi and eubacteria. They are similar to EC 1.11.1.16 versatile peroxidase (oxidation of Reactive Black 5, phenols, veratryl alcohol), but differ from the latter in their ability to efficiently oxidize a number of recalcitrant anthraquinone dyes, and inability to oxidize Mn(II). The model substrate Reactive Blue 5 is converted with high efficiency via a so far unique mechanism that combines oxidative and hydrolytic steps and leads to the formation of phthalic acid. Bacterial TfuDyP catalyses sulfoxidation. Group: Enzymes. Synonyms: DyP; DyP-type peroxidase. Enzyme Commission Number: EC 1.11.1.19. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0500; dye decolorizing peroxidase; EC 1.11.1.19; DyP; DyP-type peroxidase. Cat No: EXWM-0500.
Dyed Polycaprolactone
This product we offer is a degradable polymer. Group: Biodegradable polymers. Alternative Names: PCL. CAS No. 24980-41-4. Pack Sizes: 5 g in glass bottle. Product ID: oxepan-2-one. Molecular formula: 114.14g/mol. Mole weight: (C6H10O2)n. C1CCC(=O)OCC1. 1S/C6H10O2/c7-6-4-2-1-3-5-8-6/h1-5H2. PAPBSGBWRJIAAV-UHFFFAOYSA-N.
It is produced by the strain of Westerdykella multispora F50733. It is an immunologically active substance. It can strongly inhibit LPS-induced B cell proliferation and the production of B cell polyclonal IgM antibody, as well as T cell proliferation. The expression of IL-2 and IL-4 genes in Th cells was inhibited. CAS No. 1097679-78-1. Molecular formula: C14H16O4. Mole weight: 248.27.
DyLight 3.5 CEP
DyLight 3.5 CEP is a fluorescent dye used for oligonucleotide labeling. Synonyms: Cy3.5 Phosphoramidite; 1H-Benz[e]indolium, 2-[3-[3-[3-[[[bis(1-methylethyl)amino](2-cyanoethoxy)phosphino]oxy]propyl]-1,3-dihydro-1,1-dimethyl-2H-benz[e]indol-2-ylidene]-1-propen-1-yl]-3-[3-[(4-methoxyphenyl)diphenylmethoxy]propyl]-1,1-dimethyl-, chloride (1:1); Cy 3.5 Phosphoramidite; Cyanine 3.5 Phosphoramidite; 1-[3-(4-monomethoxy)propyl]-1'-[3 -[(2-cyanoethyl)-(N,N-diisopropyl)-phosphoramidite]propyl]-3,3,3',3'-Tetramethyl-4,5-benzoindolecyanine chloride. Grade: ≥85.0%. CAS No. 916753-57-6. Molecular formula: C66H74ClN4O4P. Mole weight: 1053.74.
DyLight 3 CEP
DyLight 3 CEP is a fluorescent dye used for oligonucleotide labeling. Synonyms: Cy3 MMTr CE Phosphoramidite; 1-[3-(4-monomethoxytrityloxy)propyl]-1'-[3-[(2-cyanoethyl)-(N,N-diisopropyl)phosphoramidityl]propyl]-3,3,3',3'-tetramethylindocarbocyanine chloride; Cyanine 3 Phosphoramidite. Grade: ≥90%. CAS No. 182873-76-3. Molecular formula: C58H70CIN4O4P. Mole weight: 953.64.
DyLight 5 CEP
DyLight 5 CEP is a fluorescent dye used for oligonucleotide labeling. Synonyms: Cy5 MMTr CE Phosphoramidite; 1-[3-(4-monomethoxytrityloxy)propyl]-1'-[3-[(2-cyanoethyl)-(N,N-diisopropylphosphoramidityl]propyl]-3,3,3',3'-tetramethylindodicarbocyanine chloride; Cyanine 5 Phosphoramidite. Grade: 95%. CAS No. 182873-67-2. Molecular formula: C60H72CIN4O4P. Mole weight: 979.68.
DyLight DY547 CEP
DyLight DY547 CEP is a fluorescent dye used for oligonucleotide labeling. Grade: ≥90%. Molecular formula: C38H54IN4O2P. Mole weight: 756.74.
DyLight DY647 CEP
DyLight DY647 CEP is a fluorescent dye used for oligonucleotide labeling. Grade: ≥85%. Molecular formula: C47H63N4O5PS. Mole weight: 827.07.
DyLight DY677 CEP
DyLight DY677 CEP is a fluorescent dye used for oligonucleotide labeling. Grade: ≥85%. Molecular formula: C55H67N4O5PS. Mole weight: 927.18.
Dymanthine
Dymanthine is an anthelminthic. Dymanthine has the potential for the research of multiple intestinal helmintic infestations [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: N,N-Dimethyloctadecan-1-amine. CAS No. 124-28-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 250 mg; 500 mg. Product ID: HY-121429.
Dymron
Dymron. Uses: Designed for use in research and industrial production. Additional or Alternative Names: dimuron;dymrone;k223;n-(4-methylphenyl)-n'-(1-methyl-1-phenylethyl)-ure;n-(4-methylphenyl)-n'-(1-methyl-1-phenylethyl)urea;n-(alpha,alpha-dimethylbenzyl)-n(sup1)-p-tolylurea;shouron;showrone. Product Category: Heterocyclic Organic Compound. CAS No. 42609-52-9. Molecular formula: C17H20N2O. Mole weight: 268.358. Density: 1.108g/cm³. Product ID: ACM42609529. Alfa Chemistry ISO 9001:2015 Certified. Categories: Daimuron, Dymon Asia.
dynamin GTPase
An enzyme with a molecular mass of about 100 kDa that is involved in endocytosis and is instrumental in pinching off membrane vesicles. Group: Enzymes. Enzyme Commission Number: EC 3.6.5.5. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4716; dynamin GTPase; EC 3.6.5.5. Cat No: EXWM-4716.
A cell-permeable, allosteric Dynamin inhibitor (IC50=6.9uM and 14uM for full length Dynamin I and Dynamin II GTPase activity, respectively, in vitro). 10uM of this compound results in cytokinesis failure at the abscission stage in HeLa cultures, with 82% of cells that enter into mitosis becoming multinucleated, and with 97% resulting in cell death. However, it displays a much reduced effect in NIH3T3 cells at the same concentration. It elicits a dose-dependent reduction in cell growth against SMA-560, SJ-G2, SW480, MCF-7 and A2780 cultures, as being the most sensitive among a panel of other cancer cell lines (GI50=4.0 - 37uM). It was further shown to be 6-fold more active (IC50=5.0uM) than dynamin mediated receptor mediated endocytosis (RME) in U2OS cells, and 15-fold more active (IC50=1.3uM) than Dynasore in another Dynamin I GTPase activity assay. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Dynamin inhibitory peptide
Has been found to be a peptide inhibitor of the GTPase dynamin and competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Synonyms: Dynamin inhibitory peptide; 251634-21-6; L-Proline, L-glutaminyl-L-valyl-L-prolyl-L-seryl-L-arginyl-L-prolyl-L-asparaginyl-L-arginyl-L-alanyl-; QVPSRPNRAP; HY-P1083; AKOS024456770; MS-31983; CS-0027626. Grade: >98%. CAS No. 251634-21-6. Molecular formula: C47H80N18O14. Mole weight: 1121.26.
Dynamin inhibitory peptide
Dynamin inhibitory peptide competitively blocks binding of dynamin to amphiphysin, thus preventing endocytosis. Dynamin inhibitory peptide blocks the dopamine D3 effect on GABAA receptors. Uses: Designed for use in research and industrial production. Additional or Alternative Names: DYNAMIN INHIBITORY PEPTIDE;P4. Product Category: Inhibitors. Appearance: Solid. CAS No. 251634-21-6. Molecular formula: C61H107N19O14. Mole weight: 1121.25. Purity: 0.9617. Product ID: ACM251634216. Alfa Chemistry ISO 9001:2015 Certified.
Dynamin inhibitory peptide Acetate
Dynamin inhibitory peptide Acetate has been found to be a peptide inhibitor of the GTPase dynamin and competitively blocks binding of dynamin to amphiphysin thus prevents endocytosis when administered intracellularly. Molecular formula: C49H84N18O16. Mole weight: 1181.30.
Dynamin inhibitory peptide, myristoylated
An inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Synonyms: AKOS024456771; Dynamin inhibitory peptide,myristoylated; PD079118; S-251634-22-7. Grade: >99%. CAS No. 251634-22-7. Molecular formula: C61H107N19O14. Mole weight: 1330.64.
Dynamin inhibitory peptide, myristoylated acetate
An inhibitor of the GTPase dynamin that competitively blocks binding of dynamin to amphiphysin, preventing endocytosis. Molecular formula: C63H111N19O16. Mole weight: 1390.67.
Dynarrestin is a aminothiazole inhibitor of cytoplasmic dyneins 1 and 2. Dynarrestin rapidly and reversibly inhibits dynein 1-driven microtubule gliding in vitro plus a range of dynein 1- and 2-dependent processes in cells without affecting ATP hydrolysis and interfering with ciliogenesis. Dynarrestin suppresses hedgehog (Hh)-dependent proliferation of neuronal precursors and tumor cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2222768-84-3. Pack Sizes: 5 mg; 10 mg; 50 mg. Product ID: HY-121802.
Dynarrestin is a potent and selective reversible inhibitor of dynein 1 and 2. Dynarrestin exhibits reversible inhibition of cytoplasmic dynein 1-dependent microtubule binding and cytoplasmic dynein 2-dependent intraflagellar transport. Synonyms: Ethyl 4-(4-(diethylamino)phenyl)-2-((2,4-difluorophenyl)amino)thiazole-5-carboxylate; 4-(4-Diethylaminophenyl)-2-(2,4-difluoro-phenylamino)-thiazole-5-carboxylic acid ethyl ester. Grade: ≥98% by HPLC. CAS No. 2222768-84-3. Molecular formula: C22H23F2N3O2S. Mole weight: 431.5.
Dynascone®
Dynascone®. CAS No. 56973-85-4. Kosher: Y. VIGON Item # 502771. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers, galbascone.
America & Internationally
Dynascone® 10% DPG
Dynascone® 10% DPG. CAS No. MIXTURE. Kosher: Y. VIGON Item # 502772. Categories: Speciality Ingrdients Suppliers, Fragrances, Perfumers.
America & Internationally
Dynasore
Dynasore is a cell-permeable dynamin inhibitor with an IC50 of 15 ?M. Dynasore blocks cell migration. Uses: Scientific research. Group: Signaling pathways. CAS No. 304448-55-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15304.
Dynasore
Dynamin GTPase inhibitor. Endocytosis inhibitor. Viral infection inhibitor. Destabilizes actin filaments. Inhibits entry of Trypanosoma into macrophages. Group: Biochemicals. Grades: Highly Purified. CAS No. 304448-55-3. Pack Sizes: 5mg, 25mg. Molecular Formula: C18H14N2O4. 0.5H2O. US Biological Life Sciences.
Worldwide
Dynasore
Dynasore is a cell-permeable and noncompetitive inhibitor of the GTPase activity of dynamin with IC50 value of 15 μM. Synonyms: Dynamin Inhibitor I; 3-hydroxy-2-[(3,4-dihydroxyphenyl)methylene]hydrazide-2-naphthalenecarboxylic acid; N'-(3,4-dihydroxybenzylidene)-3-hydroxy-2-naphthohydrazide. Grade: 98%. CAS No. 304448-55-3. Molecular formula: C18H14N2O4. Mole weight: 322.31.
dynein ATPase
A multisubunit protein complex associated with microtubules. Hydrolysis of ATP provides energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome towards the microtubule's minus end. It also functions in the movement of eukaryotic flagella and cilia. It consists of two heavy chains (about 500 kDa), three-four intermediate chains (about 70 kDa) and four light chains (about 50 kDa). Group: Enzymes. Synonyms: dynein adenosine 5'-triphosphatase. Enzyme Commission Number: EC 3.6.4.2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4704; dynein ATPase; EC 3.6.4.2; dynein adenosine 5'-triphosphatase. Cat No: EXWM-4704.
Dynemicin A
It is produced by the strain of Micromonospora chersina sp. M 956-I and M. globosa. Dynemicin A has a strong killing effect on a variety of tumor cells at Pg/mL level. The cyclic enediyne part of enediyne antibiotics is cycled by Bergman to form aromatic diradicals, which quickly seize hydrogen atoms from the DNA skeleton and break the DNA strand, thus killing tumor cells. Synonyms: (1S,4R,4aR,14S,14aS)-1,4,4a,7,12,13,14,14a-Octahydro-6,8,11-trihydroxy-3-methoxy-1-methyl-7,12-dioxo-4a,14a-epoxy-4,14-(3-hexene-1,5-diyne-1,6-diyl)naphtho[2,3-c]phenanthridine-2-carboxylicacid; Dynemicin; BU 3420T. Grade: 95%. CAS No. 124412-57-3. Molecular formula: C30H19NO9. Mole weight: 537.47.
Dynemicin L
It is produced by the strain of Micromonospora chersina sp. M 956-I and M. globosa. The cyclic enediyne part of enediyne antibiotics is cycled by Bergman to form aromatic diradicals, which quickly seize hydrogen atoms from the DNA skeleton and break the DNA strand, thus killing tumor cells. Synonyms: 9,8,14-[1]Buten[1]yl[4]ylideneanthra[1,2-b]benz[f]azocine-19-carboxylic acid, 8-chloro-5,8,9,14,15,16-hexahydro-1,4,6,17-tetrahydroxy-20-methoxy-18-methyl-5,16-dioxo-, (8R,9R,14S,17S,18S)-(9CI). CAS No. 127032-74-0. Molecular formula: C30H22NO9Cl. Mole weight: 575.95.
Dynemicin M
It is produced by the strain of Micromonospora chersina sp. M 956-I and M. globosa. The cyclic enediyne part of enediyne antibiotics is cycled by Bergman to form aromatic diradicals, which quickly seize hydrogen atoms from the DNA skeleton and break the DNA strand, thus killing tumor cells. Synonyms: (1R)-3,4,4a,13,14,14a-Hexahydro-4a,6,8,11,14a-pentahydroxy-3β-methoxy-1β-methyl-4,14-[1,2]benzenonaphtho[2,3-c]phenanthridine-2,7,12(1H)-trione. Grade: ≥98%. CAS No. 127003-54-7. Molecular formula: C29H23NO9. Mole weight: 529.49.
Dynemicin N
It is produced by the strain of Micromonospora chersina sp. M 956-I and M. globosa. The cyclic enediyne part of enediyne antibiotics is cycled by Bergman to form aromatic diradicals, which quickly seize hydrogen atoms from the DNA skeleton and break the DNA strand, thus killing tumor cells. Synonyms: 9,8,14-[1]Buten[1]yl[4]ylideneanthra[1,2-b]benz[f]azocine-19-carboxylicacid,5,8,9,14,15,16-hexahydro-1,4,6,8,17-pentahydroxy-20-methoxy-18-methyl-5,16-dioxo-, (8R,9S,14S,17S,18S)-(9CI). CAS No. 127003-55-8. Molecular formula: C30H23NO10. Mole weight: 557.50.
Dynemicin O
It is produced by the strain of Micromonospora chersina M956-1. Although the activity of this antibiotic is lower than Dynemicin A, it still has strong anti-gram-positive bacterial activity, such as Staphylococcus aureus FDA 209P (MIC is 0.08 μg/mL). Synonyms: (1R)-3,4,4a,13,14,14a-Hexahydro-4a,6,8,11,14a,17-hexahydroxy-3β-methoxy-1β-methyl-4,14-[1,2]benzenonaphtho[2,3-c]phenanthridine-2,7,12(1H)-trione; (8R-(8alpha,9beta,14beta,17S*,18R*))-8,9,14,15-Tetrahydro-1,4,6,8,10,17-hexahydroxy-20-methoxy-18-methyl-9,8,14-(1)butanyl(4)ylideneanthra(1,2-b)benz(f)azocine-5,16,19-trione. CAS No. 138370-12-4. Molecular formula: C29H23NO10. Mole weight: 545.49.
Dynemicin P
It is produced by the strain of Micromonospora chersina M956-1. Although the activity of this antibiotic is lower than Dynemicin A, it still has strong anti-gram-positive bacterial activity, such as Staphylococcus aureus FDA 209P (MIC is 0.08 μg/mL). Synonyms: (1R)-3,4,4a,13,14,14a-Hexahydro-3β,4a,6,8,11,14a-hexahydroxy-1β-methyl-4,14-[1,2]benzenonaphtho[2,3-c]phenanthridine-2,7,12(1H)-trione; 9,8,14-(1)Butanyl(4)ylideneanthra(1,2-b)benz(f)azocine-5,16,19-trione,8,9,14,15-tetrahydro-1,4,6,8,17,20-hexahydroxy-18-methyl-, (8R-(8alpha,9beta,14beta,17S*,18R*))-. CAS No. 138370-13-5. Molecular formula: C28H21NO9. Mole weight: 515.47.
Dynemicin Q
It is produced by the strain of Micromonospora chersina M956-1. Although the activity of this antibiotic is lower than Dynemicin A, it still has strong anti-gram-positive bacterial activity, such as Staphylococcus aureus FDA 209P (MIC is 0.08 μg/mL). Synonyms: 9,8,14-(2)Buten(1)yl(4)ylideneanthra(1,2-b)benz(f)azocine-5,6,20-trione,8,9,14,15-tetrahydro-1,4,6,8,17,19-hexahydroxy-18-methyl-, (8R-(8alpha,9beta,14beta,17S*))-. CAS No. 138370-14-6. Molecular formula: C28H19NO9. Mole weight: 513.45.
Dyngo-4a
Dyngo-4a is a potent dynamin inhibitor with IC50 of 0.38 μM, 1.1?μM, and 2.3 μM for DynI (brain), DynI (rec), and DynII (rec), respectively. Synonyms: Hydroxy-Dynasore; 2-Naphthalenecarboxylic acid, 3-hydroxy-, 2-[(2,4,5-trihydroxyphenyl)Methylene]hydrazide; 3-Hydroxy-N'-(2,4,5-trihydroxybenzylidene)-2-naphthohydrazide; Dyngo 49. Grade: ≥96%. CAS No. 1256493-34-1. Molecular formula: C18H14N2O5. Mole weight: 338.31.
Dynole 2?24
Dynole 2-24 is an active in-cell inhibitor of clathrin-mediated endocytosis (CME) and an indole-based dynamin GTPase inhibitor with an IC50 of 0.56 μM for dynamin I. It is non-toxic and shows enhanced potency against Dynamin I and II in vitro and in cells (IC50(CME) = 1.9 μM), and also shows 4.4-fold selectivity for dynamin I. Synonyms: 1H-Indole-3-methanamine, N-decyl-1-[3-(dimethylamino)propyl]-; N-({1-[3-(Dimethylamino)propyl]-1H-indol-3-yl}methyl)-1-decanamine. CAS No. 1416313-72-8. Molecular formula: C24H41N3. Mole weight: 371.60.
Dynole 34-2
Dynole 34-2 is a dynamin I inhibitor with IC50 value of 1.3 μM. It also inhibits receptor-mediated endocytosis (RME) with IC50 value of 5.0 μM. Synonyms: 2-Cyano-3-[1-[3-(dimethylamino)propyl]-1H-indol-3-yl]-N-octyl-2-propenamide. Grade: ≥99% by HPLC. CAS No. 1128165-88-7. Molecular formula: C25H36N4O. Mole weight: 408.58.
Dynole 34-2
Dynole 34-2. Group: Biochemicals. Grades: Purified. CAS No. 1128165-88-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Dynole 34-2
Dynole 34-2 is a potent dynamin GTPase inhibitor (IC50s=6.9 and 14.2 μM for dynamin1 and dynamin2 GTPase activity, respectively) with antimitotic effect. Dynole 34-2 induces apoptosis, as revealed by cell blebbing, DNA fragmentation, and PARP cleavage. Dynole 34-2 also potently inhibits receptor mediated endocytosis (RME)[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1128165-88-7. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-107545.