American Chemical Suppliers
A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
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Product | Description | |
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GC PestiMix 2 10 μg/mL in Isooctane:Toluene (50:50) Quick inquiry Where to buy Suppliers range | GC PestiMix 2 10 μg/mL in Isooctane:Toluene (50:50). Uses: For analytical and research use. Group: Pesticides & Metabolites; Pesticides & Metabolites. Catalog: APS008379. Format: Mixture. Shipping: Room Temperature. | |
GC PestiMix 3 10 μg/mL in Isooctane:Toluene (50:50) Quick inquiry Where to buy Suppliers range | GC PestiMix 3 10 μg/mL in Isooctane:Toluene (50:50). Uses: For analytical and research use. Group: Pesticides & Metabolites; Pesticides & Metabolites. Catalog: APS008380. Format: Mixture. Shipping: Room Temperature. | |
GC PestiMix 4 10 μg/mL in Isooctane:Toluene (50:50) Quick inquiry Where to buy Suppliers range | GC PestiMix 4 10 μg/mL in Isooctane:Toluene (50:50). Uses: For analytical and research use. Group: Pesticides & Metabolites; Pesticides & Metabolites. Catalog: APS008381. Format: Mixture. Shipping: Room Temperature. | |
GC PestiMix 5 10 μg/mL in Isooctane:Toluene (50:50) Quick inquiry Where to buy Suppliers range | GC PestiMix 5 10 μg/mL in Isooctane:Toluene (50:50). Uses: For analytical and research use. Group: Pesticides & Metabolites; Pesticides & Metabolites. Catalog: APS008382. Format: Mixture. Shipping: Room Temperature. | |
GCr15 Quick inquiry Where to buy Suppliers range | GCr15. Uses: For analytical and research use. Group: Metal alloys. Catalog: APS008384. Shipping: Room Temperature. | |
GCr15SiMn Quick inquiry Where to buy Suppliers range | GCr15SiMn. Uses: For analytical and research use. Group: Metal alloys. Catalog: APS008385. Shipping: Room Temperature. | |
GC Stationary Phase Quick inquiry Where to buy Suppliers range | GC Stationary Phase. Group: Other Ionic Liquids. Grades: phase 1,2,3-tris(2-Cyanoethoxy)propane (TCEP), bottle of 50 g. | |
g-Cyclodextrin,2-hydroxypropylethers Quick inquiry Where to buy Suppliers range | g-Cyclodextrin,2-hydroxypropylethers. Group: Heterocyclic Organic Compound. Alternative Names: 3-Fluoro-4-nitrotoluene, 446-34-4, 2-Fluoro-4-methyl-1-nitrobenzene, 2-Fluoro-4-methylnitrobenzene, Benzene, 2-fluoro-4-methyl-1-nitro-, 3-fluoro-4-nitrobenzene, 2-fluor-4-methyl-1-nitrobenzol, SBB063399, AG-D-58639, 128446-34-4, NSC25756, PubChem1595, ACMC-1ALAQ, AC1Q5ASV, 3-fluoro-4-nitro toluene, SureCN247992, AC1L28QE, KSC237K7F, 283363_ALDRICH, 3-Fluoro-4-nitrotoluene 99%. Grades: 96%. CAS No. 128446-34-4. Product ID: ACM128446344. Molecular formula: C7H6FNO2. Mole weight: 155.13. IUPAC Name: 2-fluoro-4-methyl-1-nitrobenzene. EC Number: 207-166-5. Boiling Point: 97-98ºC3 mm Hg(lit.). Melting Point: 52-55ºC(lit.). Flash Point: >230 °F. | |
GD1a-Oligosaccharide Quick inquiry Where to buy Suppliers range | GD1a-Oligosaccharide is an esteemed compound, demonstrating remarkable potential in studying peripheral neuropathies as well as neurodegenerative disorders. Functioning as an astute modulator of ganglioside metabolism, it exerts an exquisite influence on nerve cell viability while stimulating the process of neuronal regeneration. Synonyms: GD1aSaccharide. CAS No. 1627679-86-0. Molecular formula: C48H79N3O37. Mole weight: 1290.14. | |
GD1b-Ganglioside Quick inquiry Where to buy Suppliers range | GD1b-Ganglioside is a pivotal biomolecule, finding widespread application for the comprehensive investigation and comprehension of diverse neurodegenerative ailments, including Parkinson's disease is alzheimer's disease and Multiple Sclerosis. Synonyms: GD1b-Ganglioside. CAS No. 19553-76-5. Molecular formula: C80H144N4O37. Mole weight: 1754. | |
GD1b-Oligosaccharide Quick inquiry Where to buy Suppliers range | GD1b-Oligosaccharide is a crucial component widely used in the research of neurological diseases, including Alzheimer's and Parkinson's. With its bioactive properties, GD1b-Oligosaccharide holds promise for targeted drug delivery systems, disease diagnostics and advanced research in neurobiology. Synonyms: Galb1-3GalNAcb1-4(Neu5Aca2-8Neu5Aca2-3)Galb1-4Glc. Molecular formula: C48H77N3O37Na2. Mole weight: 1334.10. | |
GD2-Ganglioside Quick inquiry Where to buy Suppliers range | GD2-Ganglioside is a complex lipid molecule extensively present within the neuroblastoma tumours cells. This molecule is the focal point of numerous immunotherapies such as chimeric antigen receptor (CAR) T-cell therapy and monoclonal antibodies and has the ability to specifically recognize and demolish GD2-Ganglioside expressing cancer cells. Synonyms: GD2-Ganglioside; Disialoganglioside-GD2. CAS No. 65988-71-8. Molecular formula: C74H134N4O32. Mole weight: 1591.9. | |
GD2-GANGLIOSIDE Quick inquiry Where to buy Suppliers range | Film (dried in situ). CAS No. 65988-71-8. Molecular Weight: 1591.86. Molecular Formula: C74H134N4O32. | |
Gd2O3 nanopowder Quick inquiry Where to buy Suppliers range | Gd2O3 nanopowder. Grades: 99.9% (REO). Product ID: ACMA00019812. | |
GD2-Oligosaccharide Quick inquiry Where to buy Suppliers range | GD2-Oligosaccharide is a biomedical product used in the research of neuroblastoma. It has been found to target the GD2 antigen present on neuroblastoma cells. Molecular formula: C42H67N3O32Na2. Mole weight: 1171.96. | |
GD2-Oligosaccharide-b-(N-acetyl-propargyl) Quick inquiry Where to buy Suppliers range | GD2-Oligosaccharide-b-(N-acetyl-propargyl) is a remarkable biomedical compound, emerging as a formidable compound in the research of neuroblastoma, an affliction predominantly encountered during early stages of life. Synonyms: GD2-Saccharide-b-NAc-propargyl. Molecular formula: C47H72N4O32Na2. Mole weight: 1251.06. | |
GD2-Oligosaccharide-desthiobiotin Quick inquiry Where to buy Suppliers range | GD2-Oligosaccharide-desthiobiotin is a compound product used in the research of GD2-positive cancers, composed of desthiobiotin and GD2 oligosaccharide. It specifically targets GD2 receptors on cancer cells. Molecular formula: C65H106N10O37 2Na. Mole weight: 1665.56. | |
GD2-Oligosaccharide-sp-biotin Quick inquiry Where to buy Suppliers range | GD2-Oligosaccharide-sp-biotin is a powerful tool used for researching various diseases such as neuroblastoma, melanoma and certain other cancers. It specifically targets GD2 oligosaccharide. The addition of biotin enables efficient detection and purification of GD2 oligosaccharide in experimental settings. Molecular formula: C65H104N10O37SNa2. Mole weight: 1695.61. | |
GD3-Ganglioside Quick inquiry Where to buy Suppliers range | GD3-Ganglioside, a glycosphingolipid, is an intricate modulator of cell growth, differentiation and apoptosis. Anti-cancer therapies utilizing GD3-Ganglioside as a therapeutic target have shown significant promise, making it a distinguished focus of research in the realm of neurodegenerative diseases such as Alzheimer's and Parkinson's disease. In addition to the fascinating roles delineated above, GD3-Ganglioside has been extensively studied for its potential as an antiviral agent owing to its involvement in the immune response. Synonyms: disialoganglioside GD3; 62010-37-1; Ganglioside GD3 Sodium Salt; Ganglioside GD3 disodium salt; PD077037. CAS No. 62010-37-1. Molecular formula: C70H123N3Na2O29. Mole weight: 1516.7. | |
GD3-Ganglioside, biotin labelled Quick inquiry Where to buy Suppliers range | ||
GD3-Oligosaccharide Quick inquiry Where to buy Suppliers range | GD3-Oligosaccharide. Group: Biobased Products. Alternative Names: Neu5Acα2, 8Neu5Acα2, 3Galβ1, 4Glc. CAS No. 38598-36-6. Product ID: BBC38598366. Molecular formula: C34H56N2O27. Mole weight: 924.81. IUPAC Name: (2S,4S,5R,6R)-5-acetamido-6-[(1S,2R)-2-[(2S,4S,5R,6R)-5-acetamido-2-carboxy-4-hydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxan-2-yl]oxy-1,3-dihydroxypropyl]-2-[(2R,3S,4S,5R,6S)-3,5-dihydroxy-2-(hydroxymethyl)-6-[(2R,3R,4R,5R)-1,2,4,5-tetrahydroxy-6-oxohexan-3-yl]oxyoxan-4-yl]oxy-4-hydroxyoxane-2-carboxylic acid. SMILES: CC (=O)N[C@@H]1[C@H] (C[C@@] (O[C@H]1[C@@H] ([C@@H] (CO)O[C@@]2 (C[C@@H] ([C@H] ([C@@H] (O2)[C@@H] ([C@@H] (CO)O)O)NC (=O)C)O)C (=O)O)O) (C (=O)O)O[C@H]3[C@H] ([C@H] (O[C@H] ([C@@H]3O)O[C@H] ([C@@H] (CO)O)[C@@H] ([C@H] (C=O)O)O)CO)O)O. | |
GDC-0068 dihydrochloride Quick inquiry Where to buy Suppliers range | Testing against a broad panel of 230 kinases, GDC-0068 only inhibits 3 kinases by >70% at 1 μM concentration (PRKG1α, PRKG1β, and p70S6K, with IC50 of 98 nM, 69 nM, and 860 nM, respectively). GDC-0068 displays >100-fold selectivity for Akt over PKA with IC50 of 3.1 μM. In LNCaP, PC3 and BT474M1 cells, GDC-0068 treatment inhibits the phosphorylation of the Akt substrate, PRAS40 with IC50 of 157 nM, 197 nM, and 208 nM, respectively. Furthermore, GDC-0068 selectively inhibits cell cycle progression and viability of cancer cell lines driven by Akt signaling, including those with defects in the tumor suppressor PTEN, oncogenic mutations in PIK3CA, and amplification of HER2, with strongest effects in HER2+ and Luminal subtypes. Oral administration of GDC-0068 in PC3 prostate tumor xenografts model induces down-regulation of p-PRAS40. In BT474-Tr xenografts, GDC-0068 treatment reduces pS6 and peIF4G levels, re-localizes FOXO3a to nucleus, and induces feedback upregulation of HER3 and pERK. Administration of GDC-0068 exhibits potent antitumor efficacy in multiple xenograft tumor models, including the PTEN-deficient prostate cancer models LNCaP and PC3, the PIK3CA H1047R mutant breast cancer model KPL-4, and MCF7-neo/HER2 tumor model. Synonyms: Ipatasertib dihydrochloride; RG-7440 dihydrochloride; GDC-0068 dihydrochloride; RG 7440 dihydrochloride; GDC 0068 dihydrochloride; RG7440 dihydrochloride; GDC0068 dihydrochloride. Grades: >98%. CAS No. 1396257-94-5. Molecular formula: C24H34Cl3N5O2. Mole weight: 530.92. | |
GDC-0077 Quick inquiry Where to buy Suppliers range | GDC-0077 is an orally available and selective PI3K inhibitor (IC50 = 0.038 + 0.003 nM) with > 300-fold selective over other Class I PI3K isoforms. GDC-0077 exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Synonyms: GDC-0077; GDC 0077; GDC0077. (2S)-2-[[2-[(4S)-4-(difluoromethyl)-2-oxo-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl]amino]propanamide. CAS No. 2060571-02-8. Molecular formula: C18H19F2N5O4. Mole weight: 407.37. | |
GDC-0084 Quick inquiry Where to buy Suppliers range | GDC-0084, a PI3K inhibitor, has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. It was just licensed to Novogen and start a Phase II trial for Glioma. Uses: Gdc-0084 is a pi3k inhibitor that has been found to have probable antineoplastic effect and could pass blood-brain barrier with favourable penetration. Synonyms: RG7666; RG-7666; RG 7666; GDC-0084; GDC0084; GDC 0084; 5-(6,6-dimethyl-4-morpholin-4-yl-8,9-dihydropurino[8,9-c][1,4]oxazin-2-yl)pyrimidin-2-amine. Grades: 98%. CAS No. 1382979-44-3. Molecular formula: C18H22N8O2. Mole weight: 382.19. | |
GDC 0152 Quick inquiry Where to buy Suppliers range | GDC 0152. Uses: For analytical and research use. Group: Chiral Molecules; Enzyme Activators, Inhibitors & Substrates. CAS No. 873652-48-3. IUPAC Name: (2R)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide. Molecular formula: C25H34N6O3S. Mole weight: 498.64. Catalog: APS873652483. SMILES: CN[C@@H] (C)C (=O)N[C@@H] (C1CCCCC1)C (=O)N2CCC[C@@H]2C (=O)Nc3snnc3c4ccccc4. Format: Neat. | |
GDC-0152 Quick inquiry Where to buy Suppliers range | GDC-0152 is a second mitochondrial activator of caspases (Smac) mimetic inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic GDC-0152 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2, which may inhibit their activities and promote the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Smac, the endogenous IAP antagonist, relies on its N-terminal four amino-acid motif for binding to IAPs. Synonyms: GDC-0152; GDC0152; GDC 0152. CAS No. 873652-48-3. Molecular formula: C25H34N6O3S. Mole weight: 498.646. | |
GDC-0326 Quick inquiry Where to buy Suppliers range | GDC-0326 is a selective PI3Kα (α-Isoform of Phosphoinositide 3-Kinase) inhibitor. GDC-0326 is highly selective over other kinases. It has low plasma CL in human. In PI3 kinase family, there are four class I PI3K isoforms including α, β, δ, and γ and PI3Kα is the most commonly associated with cancers, so GDC-0326 may become a drug candidate for cancer treatment. Uses: Anti-cancer. Synonyms: GDC-0326; GDC 0326; GDC0326; (S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4]oxazepin-9-yl)oxy)propanamide. Grades: 98%. CAS No. 1282514-88-8. Molecular formula: C19H22N6O3. Mole weight: 382.42. | |
GDC-0339 Quick inquiry Where to buy Suppliers range | GDC-0339, also called as SCHEMBL14801965, is a selective inhibitor of BaF3 PIM1 that has the potential for treatment of cancer. BaF3 PIM1: IC50= 43.6 nM; PIM1 LC-3K: IC50= 0.04 nM. Synonyms: 5-amino-N-[5-[(4R,5R)-4-amino-5-fluoroazepan-1-yl]-1-methylpyrazol-4-yl]-2-(2,6-difluorophenyl)-1,3-thiazole-4-carboxamideGDC-0339; GDC 0339; GDC0339;SCHEMBL14801965BDBM110706CS-4775; HY-16976; CS 4775; HY 16976; CS4775; HY16976; US8614206, 139. CAS No. 1428569-85-0. Molecular formula: C20H22F3N7OS. Mole weight: 465.50. | |
GDC-0349 Quick inquiry Where to buy Suppliers range | GDC-0349 is a small molecule anticaner drug candidate, being developed by Genentech. As of July 2012, Genentech has filed phase I trial of GDC-0349 for evaluating the Safety and Tolerability of GDC-0349 in Patients With Locally Advanced or Metastatic Solid Tumors or Non Hodgkin's Lymphoma. Synonyms: GDC-0349; GDC 0349; GDC0349; RG7603. CAS No. 1207360-89-1. Molecular formula: C24H32N6O3. Mole weight: 452.559. | |
GDC-0425 Quick inquiry Where to buy Suppliers range | This active molecular is an selective Checkpoint kinase 1 (Chk1) inhibitors and it enhances gemcitabine efficacy in tumor xenograft models. GDC-0425 was safe and yielded responses in patients with a variety of cancers. In Oct 2013, GDC 0425 was in phase I trials for Solid tumours and Lymphoma (late-stage disease) in USA and France. In May 2014, Genentech completed a phase I trial in Lymphoma and Solid tumours (late-stage disease) in USA and France. Uses: Solid tumours and lymphoma. Synonyms: GDC-0425; GDC 0425; GDC0425; 5-((1-ethylpiperidin-4-yl)oxy)-9H-pyrrolo[2,3-b:5,4-c']dipyridine-6-carbonitrile;RG-7602; RG 7602; RG7602. Grades: 98%. CAS No. 1200129-48-1. Molecular formula: C18H19N5O. Mole weight: 321.38. | |
GDC-0449, SMO Inhibitor (2-Chloro-N- (4-chloro-3- (pyridine-2-yl) phenyl) -4- (methylsulfonyl) benzamide, HhAntag691) Quick inquiry Where to buy Suppliers range | A potent inhibitor of Smoothened (SMO), a key mediator of Hedgehog (Hh) signaling pathway. Inhibition of SMO renders the transcription factor GLI inactive, thus preventing the expression of genes that mediate the role of Hh on tumor growth. Group: Biochemicals. Grades: Highly Purified. CAS No. 879085-55-9. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
GDC-0575 Quick inquiry Where to buy Suppliers range | GDC-0575 is a highly-selective, potent and oral small-molecule Chk1 inhibitor (IC50 = 1.2?nM). Uses: Protein kinase inhibitors. Synonyms: ARRY-575; RG7741; GDC0575. Grades: ≥98%. CAS No. 1196541-47-5. Molecular formula: C16H20BrN5O. Mole weight: 378.27. | |
GDC-0623 Quick inquiry Where to buy Suppliers range | GDC-0623 is an orally active, selective MEK inhibitor with potential antineoplastic activity. MEK inhibitor GDC-0623 specifically inhibits mitogen-activated protein kinase kinase (MEK or MAP/ERK kinase), resulting in inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK is a key component of the RAS/RAF/MEK/ERK signaling pathway that regulates cell growth; constitutive activation of this pathway has been implicated in many cancers. Synonyms: GDC0623; GDC-0632; GDC 0632; G868; G 868; G-868. CAS No. 1168091-68-6. Molecular formula: C16H14FIN4O3. Mole weight: 456.216. | |
GDC-0810 (ARN-810) Quick inquiry Where to buy Suppliers range | GDC-0810, also known as ARN-810 and RG6046, an orally bioavailable Selective Estrogen Receptor Degrader (SERD) that demonstrates robust activity in tamoxifen-resistant breast cancer xenografts. Synonyms: GDC0810; GDC 0810; GDC-0810; ARN810; ARN 810; ARN-810; RG6046; RG-6046; RG 6046. Grades: 98%. CAS No. 1365888-06-7. Molecular formula: C26H20ClFN2O2. Mole weight: 446.91. | |
GDC-0834 Quick inquiry Where to buy Suppliers range | GDC-0834 is a potent and selective inhibitor of Bruton's tyrosine kinase (BTK), investigated as a potential treatment for rheumatoid arthritis. In vitro metabolite identification studies in hepatocytes revealed predominant formation of an inactive metabolite (M1) via amide hydrolysis in human. Synonyms: GDC-0834; GDC0834; GDC 0834. CAS No. 1133432-46-8. Molecular formula: C33H36N6O3S. Mole weight: 596.74. | |
GDC-0837 Quick inquiry Where to buy Suppliers range | GDC-0834 is a small molecule inhibitor of Btk potentially useful in the treatment of RA and lymphoid malignancies. Administration of GDC-0834 (30 -- 100 mg/kg) in a rat CIA model induced a decrease of ankle swelling and reduction of morphologic pathology in a dose-dependent manner. Synonyms: GDC-0837; GDC 0837; GDC0837. CAS No. 1133432-49-1. Molecular formula: C33H36N6O3S. Mole weight: 596.74. | |
GDC-0853 Quick inquiry Where to buy Suppliers range | GDC-0853 is a Bruton's tyrosine kinase (BTK) inhibitor originated by Genentech. GDC-0853 can inhibit the activity of BTK and prevent the activation of the B-cell antigen receptor (BCR) signaling pathway. This leads to the inhibition of the growth of malignant B-cells that overexpress BTK. Phase III clinical trials for the treatment of Multiple sclerosis and Phase II clinical trials for the treatment of Chronic urticaria and Systemic lupus erythematosus are on-going. Uses: Rheumatoid arthritis; autoimmune disorders. Synonyms: Fenebrutinib; RG 7845; RG7845; GDC0853; RG-7845; GDC 0853; (S)-2-(3'-(hydroxymethyl)-1-methyl-5-((5-(2-methyl-4-(oxetan-3-yl)piperazin-1-yl)pyridin-2-yl)amino)-6-oxo-1,6-dihydro-[3,4'-bipyridin]-2'-yl)-7,7-dimethyl-3,4,7,8-tetrahydro-2H-cyclopenta[4,5]pyrrolo[1,2-a]pyrazin-1(6H)-one. Grades: 98%. CAS No. 1434048-34-6. Molecular formula: C37H44N8O4. Mole weight: 664.81. | |
GDC 0879 Quick inquiry Where to buy Suppliers range | GDC 0879. Group: Biochemicals. Grades: Purified. CAS No. 905281-76-7. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
GDC-0879 Quick inquiry Where to buy Suppliers range | GDC-0879, a highly selective, potent, and orally bioavailable RAF small-molecule inhibitor. In GDC-0879-treated mice, both cell line- and patient-derived BRAF(V600E) tumors exhibited stronger and more sustained pharmacodynamic inhibition (>90% for 8 hours) and improved survival compared with mutant KRAS-expressing tumors. Despite the involvement of activated RAF signaling in RAS-induced tumorigenesis, decreased time to progression was observed for some KRAS-mutant tumors following GDC-0879 administration. Moreover, striking differences were noted for RAF and MEK inhibition across a panel of 130 tumor cell lines. Whereas GDC-0879-mediated efficacy was associated strictly with BRAF(V600E) status, MEK inhibition also attenuated proliferation and tumor growth of cell lines expressing wild-type BRAF (81% KRAS mutant, 38% KRAS wild type). The responsiveness of BRAF(V600E) melanoma cells to GDC-0879 could be dramatically altered by pharmacologic and genetic modulation of phosphatidylinositol 3-kinase pathway activity. These data suggest that GDC-0879-induced signaling changes are dependent on the point of oncogenic activation within the RAS network. Taken together, these studies increase our understanding of the molecular determinants for antitumor efficacy resulting from RAF pathway inhibition and have implications for therapeutic intervention in the clinic. Synonyms: GDC0879; GDC-0879; GDC 0879. CAS No. 905281-76-7. Molecular formula: C19H18N4O2. Mole weight: 334.37182. | |
GDC-0879 Quick inquiry Where to buy Suppliers range | GDC-0879. Group: Biochemicals. Alternative Names: 2,3-Dihydro-5-[1-(2-hydroxyethyl)-3-(4-pyridinyl)-1H-pyrazol-4-yl]-1H-Inden-1-one Oxime. Grades: Highly Purified. CAS No. 905281-76-7. Pack Sizes: 2.5mg. Molecular Formula: C19H18N2O4, Molecular Weight: 334.37. US Biological Life Sciences. | Worldwide |
GDC-0917 Quick inquiry Where to buy Suppliers range | CUDC-427, also known as, GDC-0917, is an orally available, monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity. Smac mimetic CUDC-427 binds to the Smac binding groove on IAPs, including the direct caspase inhibitor X chromosome-linked IAP (XIAP) and the cellular IAPs 1 and 2. This inhibits the activities of these IAPs and promotes the induction of apoptosis through apoptotic signaling pathways. IAPs are overexpressed by many cancer cell types and suppress apoptosis by binding to and inhibiting active caspases-3, -7 and -9 via their baculoviral lAP repeat (BIR) domains. Synonyms: GDC-0917; GDC0917; GDC 0917; CUDC-427; CUDC427; CUDC-427. Grades: 0.98. CAS No. 1446182-94-0. Molecular formula: C29H36N6O4S. Mole weight: 564.705. | |
GDC-0927 Quick inquiry Where to buy Suppliers range | GDC-0927 (SRN-927) is a selective oral estrogen receptor degrader (SERD) in a phase I clinical trial for the treatment of postmenopausal women with locally advanced or metastatic estrogen receptor positive breast cancer. Study shows well tolerability and clinical effect. Uses: The potential therapy of breast cancer caused by estrogen disorder. Synonyms: SRN-927; SRN 927; SRN927; GDC-0927; GDC 0927; GDC0927. CAS No. 1642297-01-5. Molecular formula: C28H28FNO4. Mole weight: 461.52. | |
GDC0941 Quick inquiry Where to buy Suppliers range | GDC-0941 is a potent pan inhibitor of class I catalytic subunits of PI3K that inhibits p110α, β, δ, and γ with IC50 values of 3, 33, 3, and 75 nM. Synonyms: 4-(2-(1H-indazol-4-yl)-6-((4-(methylsulfonyl)piperazin-1-yl)methyl)thieno[3,2-d]pyrimidin-4-yl)morpholine; GDC-0941; GDC 0941; GDC0941; RG7321; RG-7321; RG 7321; GNE0941; GNE-0941; GNE 0941; Pictrelisib; Pictilisib. CAS No. 957054-30-7. Molecular formula: C23H27N7O3S2. Mole weight: 513.635. | |
GDC-0941 Bimesylate Quick inquiry Where to buy Suppliers range | Potent inhibitor of Phosphatidylinositol 3-kinase (PI3K). Group: Biochemicals. Alternative Names: 2-(1H-Indazol-4-yl)-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3,2-d]pyrimidine Methanesulfonate. Grades: Highly Purified. CAS No. 957054-33-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
GDC-0941 dimethanesulfonate Quick inquiry Where to buy Suppliers range | GDC-0941 dimethanesulfonate is a potent inhibitor of PI3Kα/δ with modest selectivity against p110β and p110&gamma. It is a novel selective class I phosphatidylinositol-3-kinase (PI3K) inhibitor. It is designed to bind the ATP-binding pocket of PI3K and to prevent formation of phosphatidylinositol-3, 4, 5-triphosphate (PIP3), a second messenger that transmits PI3K downstream signals. It causes growth inhibition in a variety of cancer cell lines, including A2780, MDA-MB-361, PC3, and U87MG. It also inhibits the growth of trastuzumab-sensitive and -resistant HER2-amplied cancer cells which harbor p110( mutations or PTEN loss. It also reduces tumor volume in different xenograft models. Synonyms: GDC-0941 dimethanesulfonate; GDC 0941 dimethanesulfonate; GDC0941 dimethanesulfonate; Pictilisib dimethanesulfonate; GDC-0941 (2 MeSO3H salt). Grades: >98%. CAS No. 957054-33-0. Molecular formula: C25H35N7O9S4. Mole weight: 705.85. | |
GDC-0941, Free Base, PI3K Inhibitor Quick inquiry Where to buy Suppliers range | GDC-0941 is a potent inhibitor of p110a and p110d (IC?? = 3nM). It selectively binds to PI3K isoforms in an ATP-competitive manner, inhibiting the production of the secondary messenger phosphatidylinositol-3,4,5-trisphosphate (PIP3) and activation of the PI3K/Akt signaling pathway.GDC-0941 is a phosphatidylinositol 3-kinase (PI3K) inhibitor. Folkes, A.J., et al. "The identification of 2-(1H-indazol-4-yl)-6-(4-methanesulfonyl-piperazin-1-ylmethyl)-4-morpholin-4-yl-thieno[3,2-d]pyrimidine (GDC-0941) as a potent, selective, orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer." J. Med. Chem. 51: 5522-5532 (2008).GDC-0941 inhibited the growth of >70% of breast cancer cell lines tested, with EC50's <1 µM. GDC-0941 also demonstrated antitumor activity in preclinical models of breast cancer. Yao, E., et al. "Suppression of HER2/HER3-mediated growth of breast cancer cells with combinations of GDC-0941 PI3K inhibitor, trastuzumab, and pertuzumab." Clin. Cancer Res. 15: 4147-4156 (2009).The combination of GDC-0941 with trastuzumab is highly efficacious in the treatment of cancer cells in vitro and tumors in vivo. GDC-0941 also has antitumor activity in the treatment of trastuzumab-resistant cells and tumors. Junttila, T.T., et al. "Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941." Cancer Cell 15: 429-440 (2009).GDC-0941 inhibits the activity of recombinant PI3K in vitro with IC50's of 0.003 µM (P110α), 0.033 µM (P110 β), 0.003 µM (P110δ), 0.075 µM (P110γ), 0.58 µM (mTOR) and 1.23 µM (DNA-PK). GDC-0941 inhibited the growth of tumor cells in vitro with IC50's of 0.95 µM (U87MG), 0.07 µM (IGROV-1), 0.15 µM (DETROIT 562), 0.28 µM (PC3) and 0.54 µM (SKOV-3). GDC-0941 also inhibited the growth of U87 MG glioblastoma xenografts and IGROV-1 ovarian cancer xenografts in mice. Raynaud, F.I., et al. "Biological properties of potent inhibitors of class I phosphatidylinositide 3-kinases: from PI-103 through PI-540, PI-620 to the oral agent GDC-0941." Mol. Cancer Ther. 8: 1725-1738 (2009). Group: Biochemicals. Alternative Names: 2- (1H-indazol-4-yl) -6- ( (4- (methylsulfonyl) piperazin-1-yl) methyl) -4-morpholinothieno[3, 2-d]pyrimidine; 4-[2- (1H-Indazol-4-yl) -6-[[4- (methylsulfonyl) piperazin-1-yl]methyl]thieno[3, 2-d]pyrimidin-4-yl]morpholine; GDC 0941; GDC 941; GNE 0941; Pictilisib; Pictrelisib. Grades: Highly Purified. CAS No. 957054-30-7. Pack Sizes: 25mg, 50mg, 100mg. Molecular Formula: C??H??N?O?S?, Molecular Weight: 513.64. US Biological Life Sciences. | Worldwide |
GDC-0980 Quick inquiry Where to buy Suppliers range | GDC-0980. Group: Biochemicals. Alternative Names: (S)-1-[4-[[2-(2-Aminopyrimidin-5-yl)-7-methyl-4-(morpholin-4-yl)thieno[3,2-d]pyrimidin-6-yl]methyl]piperazin-1-yl]-2-hydroxypropan-1-one; Apitolisib; G 038390; G 038390.1; GDC 0980; GDC 0980.1; GNE 390; RG 7422. Grades: Highly Purified. CAS No. 1032754-93-0. Pack Sizes: 500ug. Molecular Formula: C23H30N8O3S, Molecular Weight: 498.6. US Biological Life Sciences. | Worldwide |
GDC-0980, 99% Quick inquiry Where to buy Suppliers range | GDC-0980, 99%. Group: Pathway Inhibitors. CAS No. 1032754-93-0. Pack Sizes: 10mg. ID EBT1025. | |
GDC-0994 Quick inquiry Where to buy Suppliers range | GDC-0994, also known as RG7842, is an orally available inhibitor of extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon oral administration, GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways. This prevents ERK-dependent tumor cell proliferation and survival. The mitogen-activated protein kinase (MAPK)/ERK pathway is upregulated in a variety of tumor cell types and plays a key role in tumor cell proliferation, differentiation and survival. Uses: Antineoplastic agents. Synonyms: GDC0994; GDC 0994; RG7842; RG-7842; RG 7842; Ravoxertinib. CAS No. 1453848-26-4. Molecular formula: C21H18ClFN6O2. Mole weight: 440.863. | |
GDNF family receptor alpha-1 isoform b preproprotein (117-130) Quick inquiry Where to buy Suppliers range | GDNF family receptor alpha-1. Uses: Tumor Antigen Derived Peptides. CAS No. Product ID: ta-119. | |
GDP-2F-Fuc ammonium salt Quick inquiry Where to buy Suppliers range | A competitive inhibitor of fucosyltransferases FUT3, FUT5, FUT6 and FUT7 with Ki values in low micromolar range. This fluorinated GDP-fucose analog inhibits oligosaccharide core fucosylation of N-linked glycans in animal and plant cells. Synonyms: GDP-2-deoxy-2-fluoro-L-fucose ammonium salt. Molecular formula: C16H30FN7O14P2. Mole weight: 625.39. | |
GDP366 Quick inquiry Where to buy Suppliers range | GDP366 is a novel small molecule compound which potently and selectively inhibited the expression of both survivin and Op18. GDP366 induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Synonyms: 1-[4-(4-aminothieno[2,3-d]pyrimidin-5-yl)phenyl]-3-(3-methylphenyl)urea; GDP 366; GDP-366; GDP366. CAS No. 501698-03-9. Molecular formula: C20H17N5OS. Mole weight: 375.45. | |
GDP-6-deoxy-a-D-talose Quick inquiry Where to buy Suppliers range | ||
Gdp-alpha-D-mannose,disodium salt Quick inquiry Where to buy Suppliers range | Gdp-alpha-D-mannose,disodium salt. Group: Heterocyclic Organic Compound. Alternative Names: GDP-ALPHA-D-MANNOSE, DISODIUM SALT;GDP-MAN, NA2;GUANOSINE-5-DIPHOSPHATE-ALPHA-D-MANNOSE, 2NA;GUANOSINE-5-DIPHOSPHO-ALPHA-D-MANNOSE, DISODIUM;GUANOSINE 5-DIPHOSPHO-D-MANNOSE SODIUM SALT;GUANOSINE 5-DIPHOSPHO-D-MANNOSE*DISODIU M;GUANOSINE 5-DIPHOSPHO-D-MANNOSE*TYPE I SODIUM;guanosine 5-diphospho-d-mannose sodium salt from saccharomyces cerevisiae. CAS No. 103301-73-1. Molecular formula: C16H23N5Na2O16P2. Mole weight: 649.3. Safty Description: 26-36. Hazard statements: Xn. | |
GDPβS Quick inquiry Where to buy Suppliers range | GDPβS has been found to exhibit activities as an inhibitor of G-coupled protein. Synonyms: Guanosine-5'-(β-thio)-diphosphate, Sodium salt. Grades: ≥ 90 % by HPLC. Molecular formula: C10H15N5O10P2S (free acid). Mole weight: 459.26 (free acid). | |
GDP-b-L-glucose ammonium salt Quick inquiry Where to buy Suppliers range | GDP-b-L-glucose ammonium salt is an extensively employed compound, serving as a pivotal tool for examining enzymatic activities and metabolic pathways linked to glucose. This product facilitates profound insights into the intricate mechanisms underlying glucose-related disorders, including diabetes. Synonyms: Guanosine 5'-Diphosphate b-L-glucose ammonium salt; Guanosine 5'-(Trihydrogen Diphosphate) b-L-glucose ammonium salt. Molecular formula: C16H31N7O16P2. Mole weight: 639.40. | |
GDP-D-galactose Quick inquiry Where to buy Suppliers range | GDP-D-galactose, an indispensable biochemical molecule within the biomedical industry, encompasses a pivotal role in enzymatic reactions. As a substrate for glycosylation-involved enzymes, this vital compound becomes essential for the synthesis of diverse glycoproteins and glycolipids. CAS No. 41432-88-6. Molecular formula: C16H25N5O15P2. Mole weight: 589.4. | |
GDP-D-glucose sodium salt Quick inquiry Where to buy Suppliers range | Cas No. 103301-72-0. | |
GDP-D-Man.2Na Quick inquiry Where to buy Suppliers range | Cas No. 103301-73-1. | |
GDP-D-mannose diammonium salt Quick inquiry Where to buy Suppliers range | GDP-D-mannose diammonium salt is a pivotal compound within the biomedical field assuming the fundamental position as a forerunner for the synthesis of GDP-mannose. This molecule is crucially engaged in glycosylation mechanisms. Molecular formula: C16H23N5O16P2 N2H8. Mole weight: 639.4. | |
GDP-D-mannose disodium salt Quick inquiry Where to buy Suppliers range | GDP-D-mannose disodium salt is an invaluable compound, playing a pivotal role in the research of disorders pertaining to compromised glucose metabolism. Functioning as a critical intermediate within biosynthetic pathways, it specifically facilitates the synthesis of sugar nucleotides. Synonyms: Guanosine 5-diphospho-a-D-mannose disodium salt; GDP-Man. CAS No. 103301-73-1. Molecular formula: C16H23N5O16P2Na2. Mole weight: 649.3. | |
GDP-Gel / GDP-Agarose Quick inquiry Where to buy Suppliers range | GDP-Gel is the GDP coupled to a polymeric gel by the terminal phosphate, which can be used in the affinity purification of fucosyltransferases. Synonyms: Guanosine- 5'- O- diphosphate, immobilized on a polymeric matrix. | |
GDP-L-Fuc.2Na Quick inquiry Where to buy Suppliers range | Cas No. 15839-70-0. | |
GDP-L-fucose Quick inquiry Where to buy Suppliers range | GDP-L-fucose is a pivotal biomolecule acting as a precursory compound to facilitate the synthesis of fucose-containing glycoconjugates implicated in diverse cellular phenomena. Its exceptional significance lies in the research of glycosylation patterns, evaluation of protein functioning repercussions and investigation into possible therapeutic approaches targeting conditions like cancer and inflammation. Synonyms: GDP-b-L-fucose; Guanosine 5-diphospho-b-L-fucose; GDP-Fucose; Guanosine diphosphofucose; Guanosine 5'-diphospho-beta-L-fucopyranose; guanosine 5'-[3-(6-deoxy-beta-L-galactopyranosyl) dihydrogen diphosphate]. Grades: ≥90%. CAS No. 15839-70-0. Molecular formula: C16H25N5O15P2. Mole weight: 589.34. | |
GDP-L-fucose diammonium salt Quick inquiry Where to buy Suppliers range | GDP-L-fucose diammonium salt is an indispensable compound, serving as a vital substrate for fucosyltransferase. This compound intricately contributes to the biosynthesis of fucosylated glycans. Molecular formula: C15H23N5O15P2 N2H8. Mole weight: 623.41. | |
GDP-L-fucose disodium salt Quick inquiry Where to buy Suppliers range | Substrate for fucosyltransferase. Synonyms: Guanosine 5'-pyrophosphate, β-L-fucopyranosyl ester Disodium Salt; Guanosine pyrophosphate, L-fucosyl ester Disodium Salt; Guanosine diphosphofucose Disodium Salt; Guanosine diphosphate fucose Disodium Salt; Guanosine 5'-pyrophosphate, L-fucosyl ester Disodium Salt; Guanosine 5'-diphospho-β-L-fucose Disodium Salt; GDP-Fucose Disodium Salt. Grades: ≥95%. CAS No. 148296-47-3. Molecular formula: C16H23N5O15P2Na2. Mole weight: 633.31. | |
GDP-L-fucose disodium salt - low endotoxin grade Quick inquiry Where to buy Suppliers range | GDP-L-fucose disodium salt - low endotoxin grade is a remarkably valuable compound within the biomedical realm, used for studying an array of ailments intertwined with cell surface glycans. By functioning as a precursor in fucosylated carbohydrate synthesis, it assumes an indispensable role in facilitating vital cellular adhesion and signaling mechanisms. Molecular formula: C16H23N5O15P2Na2. Mole weight: 633.31. | |
Gdp-L-galactose Quick inquiry Where to buy Suppliers range | Gdp-L-galactose. Group: Heterocyclic Organic Compound. Alternative Names: GDP-L-Galactose. CAS No. 6815-91-4. Molecular formula: C16H25N5O16P2. Mole weight: 605.341. | |
GDP-L-galactose sodium salt Quick inquiry Where to buy Suppliers range | GDP-L-galactose sodium salt, an indispensable element in the field of biomedicine, assumes a pivotal function in the amalgamation of Vitamin C, thereby facilitating the amelioration of scurvy and associated ailments. This efficacious product showcases its potential in enhancing general well-being and mitigating deficiencies stemming from insufficient levels of Vitamin C. Synonyms: Guanosine 5-diphosphate-L-galactose. CAS No. 6815-91-4. Molecular formula: C16H23N5O16P2Na2. Mole weight: 649.30. | |
GDP - lyophilized Quick inquiry Where to buy Suppliers range | Guanosine 5'-diphosphate could be used to study cell signaling related to G-coupled protein receptors as well as some GTPases. Synonyms: Guanosine-5'-diphosphate, Sodium salt. Grades: ≥ 90 % by HPLC. CAS No. 43139-22-6. Molecular formula: C10H15N5O11P2(free acid). Mole weight: 443.20 (free acid). |