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| Product | Description | |
|---|---|---|
| Immobilized porcine pepsin | Immobilized porcine pepsin is ideal for digestion of IgG to generate F(ab)2 fragments. Pepsin is a non-specific endopeptidase that cleaves peptide bonds preferentially at aromatic residues such as tyrosines and phenylalanine. It generally does not cleave at alanine, glycine or valine residue. Group: Enzymes. Synonyms: EC 3. 4. 23. 1; pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D; Pepsin A. Enzyme Commission Number: EC 3. 4. 23. 1. Purity: >95% by SDS-PAGE analysis. Stability: 12 months from delivery. Storage: 4°C. Form: Resin. Source: Porcine gastric mucosa. Species: Porcine. EC 3. 4. 23. 1; pepsin; lactated pepsin; pepsin fortior; fundus-pepsin; elixir lactate of pepsin; P I; lactated pepsin elixir; P II; pepsin R; pepsin D; Pepsin A; Immobilized pepsin. Cat No: NATE-1761. |  |
| Immobilized Proteinase K on Eupergit(R) C | Proteinase K hydrolyses keratin by cleaving peptide bonds adjacent to the carboxyl group of aliphatic and aromatic amino acids. Group: Enzymes. Synonyms: Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K; EC 3. 4. 21. 64; 39450-01-6. Enzyme Commission Number: EC 3. 4. 21. 64. Activity: >1500 U/g. Storage: 2-8°C. Form: powder (granular). Source: Tritirachium album. Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K; EC 3. 4. 21. 64; 39450-01-6; Immobilized Proteinase K. Cat No: NATE-1776. | |
| Immobilized Proteinase K on G3m | Proteinase K is an unspecific serine protease with strong proteolytic activity on denatured (in SDS) and high molecular weight native proteins. It cleaves peptide bonds mostly after the carboxyl group of N-substituted hydrophobic, aliphatic and aromatic amino acids. G3m: 25 ug proteinase K immobilized on matrix G3m per CR-column. 0.7 mAnson units immobilized per CR-column. This CR-column cuts at least 370 ug BSA per application. Nr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 16 Reaction buffer: 50 mM Tris/HCl, 5 mM NaCl, pH 8. 0Nr. 17 Washing buffer: 50 mM Tris/HCl, 1. 0 M NaCl, pH 8. 0The columns are more active in 0.1% SDS and at 40°C. Also active in PBS buffer (20 mM Na-phosphate, 150 mM NaCl at pH 7. 6). Group: Enzymes. Synonyms: Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K; EC 3. 4. 21. 64; 39450-01-6. Enzyme Commission Number: EC 3. 4. 21. 64. Purity: Chromatographically purified, free of ribo- and deoxyribonucleases. Storage: 4 °C. Source: Tritirachium album. Tritirachium alkaline proteinase; Tritirachium album serine proteinase; proteinase K; Tritirachium album proteinase K; endopeptidase K; EC 3. 4. 21. 64; 39450-01-6; Immobilized Proteinase K. Cat No: NATE-1768. | |
| Immobilized RNase A on G3m | RNase A is an endonuclease that cleaves RNA but not DNA. RNase A specifically cuts pyrimidine ribonucleotides at the 3'-adjacent phosphodiester bond Py/pN, with the intermediary formation of nucleoside-2',3'-cyclophosphate. G3m: 25 ug (2. 5 Kunitz units) RNase A per CR-column immobilized on dextranThis G3m-column digests at least 200 ug RNA per application. Nr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5 (also active with 1% SDS)Nr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5The columns are provided in storage buffer. Group: Enzymes. Synonyms: Pancreatic ribonucleases; EC 3. 1. 27. 5; RNase; RNase I; RNase A; pancreatic RNase; ...lease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4. Enzyme Commission Number: EC 3. 1. 27. 5. Storage: 4 °C. Source: Bovine pancreas. Pancreatic ribonucleases; EC 3. 1. 27. 5; RNase; RNase I; RNase A; pancreatic RNase; ribonuclease I; endoribonuclease I; ribonucleic phosphatase; alkaline ribonuclease; ribonuclease; gene S glycoproteins; Ceratitis capitata alkaline ribonuclease; SLSG glycoproteins; gene S locus-specific glycoproteins; S-genotype-asssocd. glycoproteins; ribonucleate 3'-pyrimidino-oligonucleotidohydrolase; 9001-99-4; Immobilized RNase A. Cat No: NATE-1773. | |
| Immobilized TLCK-Chymotrypsin on F7m | α-chymotrypsin hydrolyzes peptides, amides, and esters preferentially at the carboxyl groups of hydrophobic amino acids (L-tyrosine, L-phenylalanine, and L-tryptophan but also bonds of leucyl, methionyl, asparaginyl, and glutamyl residues). F7m: 1. 0 mg α-chymotrypsin per CR-column immobilized on polyvinyl. 55 units immobilized per CR-columnNr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5; also active in 0.1% SDSNr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5. Group: Enzymes. Synonyms: EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3. 4. 21. 1. Storage: 4 °C. Source: Bovine pancreas. EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; Immobilized TLCK-Chymotrypsin; Immobilized Chymotrypsin; TLCK-Chymotrypsin. Cat No: NATE-1769. | |
| Immobilized TLCK-Chymotrypsin on G3m | α-chymotrypsin hydrolyzes peptides, amides, and esters preferentially at the carboxyl groups of hydrophobic amino acids (L-tyrosine, L-phenylalanine, and L-tryptophan but also bonds of leucyl, methionyl, asparaginyl, and glutamyl residues). G3m: 25 ug α-chymotrypsin per CR-column immobilized on dextran. 1. 4 units immobilized per CR-column. This CR-column cuts at least 100 ug tubulin per application; it cuts 5 ug/minuteBSA without SDS, but at least 45 ug/minute BSA in the presence of 0.1% SDS. Nr. 5 Storage buffer: 50 mM Tris/HCl, pH 7. 5Nr. 5 Reaction buffer: 50 mM Tris/HCl, pH 7. 5; also active in 0.1% SDSNr. 6 Washing buffer: 50 mM Tris/HCl, 1 M NaCl, pH 7. 5. Group: Enzymes. Synonyms: EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin. Enzyme Commission Number: EC 3. 4. 21. 1. Storage: 4 °C. Source: Bovine pancreas. EC 3. 4. 21. 1; α-Chymotrypsin; chymotrypsins A and B; alpha-chymar ophth; avazyme; chymar; chymotest; enzeon; quimar; quimotrase; alpha-chymar; alpha-chymotrypsin A; alpha-chymotrypsin; Chymotrypsin; Immobilized TLCK-Chymotrypsin; Immobilized Chymotrypsin; TLCK-Chymotrypsin. Cat No: NATE-1770. | |
| Immobilized TPCK-Trypsin on F7m | Trypsin hydrolyzes proteins, peptides, amides and esters specifically at the carboxyl groups of the basic amino acids L-arginine or L-lysine. F7m: 1. 0 mg trypsin per CR-column, immobilized on polyvinyl10,200 ST-units immobilized per CR-column. Nr. 15 Storage buffer: 50 mM Tris/HCl at pH 8. 0 at 4°CNr. 67 Reaction buffer: 50 mM phosphate at pH 8. 0Nr. 68 Washing buffer: 50 mM phosphate at pH 8. 0, 1 M NaCl. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin. Enzyme Commission Number: EC 3. 4. 21. 4. Storage: 4 °C. Source: Bovine pancreas. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin; Immobilized TPCK-Trypsin; Immobilized Trypsin; TPCK-Trypsin. Cat No: NATE-1771. | |
| Immobilized TPCK-Trypsin on G3m | Trypsin hydrolyzes proteins, peptides, amides and esters specifically at the carboxyl groups of the basic amino acids L-arginine or L-lysine. G3m: 25 ug trypsin per CR-column, immobilized on dextran. 260 ST-units immobilized per CR-column. This CR-column cuts at least 50 ug tubulin per application. Nr. 15 Storage buffer: 50 mM Tris/HCl at pH 8. 0Nr. 67 Reaction buffer: 50 mM phosphate at pH 8. 0 (S?rensen)Nr. 68 Washing buffer: 50 mM phosphate at pH 8. 0, 1 M NaCl. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin. Enzyme Commission Number: EC 3. 4. 21. 4. Storage: 4 °C. Source: Bovine pancreas. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin; Immobilized TPCK-Trypsin; Immobilized Trypsin; TPCK-Trypsin. Cat No: NATE-1772. | |
| Immobilized Trypsin, TPCK Treated (Agarose Resin) | Trypsin immobilized on beaded agarose makes it possible to eliminate enzyme contamination of tryptic digests. The trypsin can be easily removed from the digest by separating the trypsin gel from the digestion solution. The Thermo Scientific Immobilized TPCK Trypsin is treated with L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK), which is a reagent that has been reported to inhibit chymotrypsin activity without effect on trypsin. Trypsin is a 23,200 molecular weight protein with a pH optimum between 7.5 and 9.0. The isoelectric points of trypsinogen and trypsin are 10.5 and 9.3, respectively. Trypsin has a wide range of applications including amino acid analys...estimated from the number of lysine and arginine residues in the protein. Ionexchange chromatography, paper electrophoresis or peptide mapping can be used to separate digestion fragments. Group: Enzymes. Synonyms: Immobilized Trypsin. Enzyme Commission Number: EC 3.4.21.4. Trypsin. Activity: > 200 TAME units per mL of gel. Storage: Upon receipt store at 4°C. Product is shipped at ambient temperature. Form: 2mL of settled gel supplied as a 50% slurry containing glycerol and 0.05% sodium azide as a preservative. Source: Bovine pancreas. Immobilized Trypsin, TPCK Treated (Agarose Resin); Immobilized Trypsin; Trypsin; Protein Fragmentation Enzymes Kits. Cat No: NATE-1867. | |
| Immunology/Inflammation Compound Library | A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening. - Bioactivity and safety confirmed by clinical research and trials, some of which are FDA approved; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4700. Categories: Immunology/Inflammation Compounds Libraries. |  |
| Immuno-Oncology Compound Library | A unique collection of 454 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening?- Targets include PD-1/PD-L1, HER2, STAT3, CTLA4, IDO, STING, CCR, CXCR, TLR, etc. - Detailed compound information with structure, target, and biological activity description?- NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2170. Categories: Immuno-Oncology Compounds Libraries. | |
| Imofinostat | MPT0E028 is an orally active and selective HDAC inhibitor with IC 50 s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively [1]. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MPT0E028. CAS No. 1338320-94-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124295. |  |
| Imolamine hydrochloride | Imolamine hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Angolon, Irrigor, Irri-Cor, Imolamine HCl, Imolamine hydrochloride, C14H20N4O.HCl, 318-23-0 (Parent), EINECS 239-920-4, CID27500, LA 1211, LS-99266, Phenyl-3 imino-5 diethylaminoethyl-4 oxadiazol-1,2,4, Phenyl-3 imino-5 diethylaminoethyl-4 oxadiazol-1,2,4 [French], delta(sup 2)-1,2,4-Oxadiazoline, 4-(2-(diethylamino)ethyl)-5-imino-3-phenyl-, monohydrochloride, 1,2,4-Oxadiazole-4(5H)-ethanimine, N,N-diethyl-5-imino-3-phenyl-, monohydrochloride, 1,2,4-Oxadiazole-4(5H)-ethanimine, N,N-diethyl-5-imino-3-phenyl-, monohydrochloride (9CI), 15823-89-9, delta(sup 2)-1,2,4-Oxadiazoline, 4-(2-(diethylamino)ethyl)-5-imino-3-phenyl-,monohydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 15823-89-9. Molecular formula: C14H20N4O.HCl. Mole weight: 296.796 g/mol. Purity: 0.96. IUPACName: diethyl-[2-(5-imino-3-phenyl-1,2,4-oxadiazol-4-yl)ethyl]azanium chloride. Canonical SMILES: CC[NH+](CC)CCN1C(=NOC1=N)C2=CC=CC=C2.[Cl-]. Density: 1.13g/cm³. ECNumber: 239-920-4. Product ID: ACM15823899. Alfa Chemistry ISO 9001:2015 Certified. |  |
| IMP | Inosine monophosphate, a versatile nucleotide, plays a pivotal role in the synthesis of RNA and DNA. Its diverse applications span from treating neuropathic pain and viral infection to serving as a therapeutic agent for gout. Beyond its pharmacological benefits, IMP is also found in many nutritional supplements, promising a wealth of health-promoting effects. At a cellular level, IMP exhibits potent anti-tumor and anti-inflammatory properties, opening up new avenues of research in this domain. Synonyms: Inosine-5'-monophosphate, Triethylammonium salt. Grades: ≥ 95 % by HPLC. CAS No. 108250-70-0. Molecular formula: C10H13N4O8P (free acid). Mole weight: 348.20 (free acid). |  |
| IMP-1088 | IMP-1088 is an inhibitor of N-myristoyltransferase 1 (NMT1) and NMT2 (IC50 = <1 nM for both human enzymes). It prevents rhinoviral replication without inducing cytotoxicity, and inhibits co-translational myristoylation of a specific virus-encoded protein (VP0) to block viral capsid assembly. Synonyms: EX-A2075; 1-(5-{3,4-difluoro-2-[2-(1,3,5-trimethyl-1H-pyrazol-4-yl)ethoxy]phenyl}-1-methyl-1H-indazol-3-yl)-N,N-dimethylmethanamine. Grades: ≥98%. CAS No. 2059148-82-0. Molecular formula: C25H29F2N5O. Mole weight: 453.53. | |
| IMP321 | IMP321 is an antagonist mAb which blocks the LAG-3-mediated inhibitory signal given to tumor infiltrating T cells. This allows the CD8 T cell to generate a better cytotoxic response against cancer cells. Synonyms: IMP321; IMP 321; IMP-321; Anti-LAG-3; Anti-LAG-3 monoclonal antibody; Anti-LAG-3 monoclonal antibody - Bristol-Myers Squibb; Anti-lymphocyte activation gene 3 monoclonal antibody. | |
| IMP cyclohydrolase | This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is IMP 1,2-hydrolase (decyclizing). Other names in common use include inosinicase, and inosinate cyclohydrolase. This enzyme catalyses the cyclisation of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP, a reaction which is important in de novo purine biosynthesis in archaeal species. Group: Enzymes. Synonyms: inosinicase; inosinate cyclohydrolase; IMP 1,2-hydrolase (decyclizing). Enzyme Commission Number: EC 3.5.4.10. CAS No. 9013-81-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4537; IMP cyclohydrolase; EC 3.5.4.10; 9013-81-4; inosinicase; inosinate cyclohydrolase; IMP 1,2-hydrolase (decyclizing). Cat No: EXWM-4537. | |
| IMP dehydrogenase | The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. Group: Enzymes. Synonyms: inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase. Enzyme Commission Number: EC 1.1.1.205. CAS No. 9028-93-7. IMPDH2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0109; IMP dehydrogenase; EC 1.1.1.205; 9028-93-7; inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase. Cat No: EXWM-0109. | |
| Impentamine dihydrobromide | Impentamine dihydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 149629-70-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. |  Worldwide |
| Impentamine dihydrobromide | Impentamine dihydrobromide is the dihydrobromide salt of impentamine, which is a highly selective and the most potent histamine H3 antagonist with pA2 value of 8.4. It also acts as a partial agonist in SK-N-MC cells expressing human H3 receptors. It shows > 30000-fold selectivity over histamine H1 and H2 receptors. Synonyms: 1H-Imidazole-5-pentanamine, hydrobromide (1:2); 1H-Imidazole-4-pentanamine, dihydrobromide. Grades: ≥95%. CAS No. 149629-70-9. Molecular formula: C8H17N3Br2. Mole weight: 315.05. | |
| Imperatorin | Imperatorin is an effective of NO synthesis inhibitor ( IC 50 =9.2 μmol), which also is a BChE inhibitor ( IC 50 =31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC 50 of 12.6±3.2 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Ammidin. CAS No. 482-44-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N0285. | |
| Imperatorin | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopyeuropean pharmacopoeia (ph. eur.)pharmacopoeial standards. Alternative Names: 8-Isopent-2-enyloxy-6,7-furanocoumarin,7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-buten-1-yl)oxy]-, 7H-Furo[3,2-g][1]benzopyran-7-one, 9-[(3-methyl-2-butenyl)oxy]- (8CI,9CI), Marmelide, Marmelosin, 8-Isopentenyloxypsoralene, Ammidin, NSC 402949, Imperatorin (6CI). |  |
| Imperatorin | Imperatorin. Group: Biochemicals. Alternative Names: 9-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one; Ammidin. Grades: Highly Purified. CAS No. 482-44-0. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C16H14O4. US Biological Life Sciences. | Worldwide |
| Imperatorin (9-[(3-Methyl-2-butenyl)-oxy]-7H-furo[3,2-g][1][benzopyran-7-one, Enoxypsoralen, Marmelosin, Ammidin, Pentosalen) | Imperatorin (9-[(3-Methyl-2-butenyl)-oxy]-7H-furo[3,2-g][1][benzopyran-7-one, Enoxypsoralen, Marmelosin, Ammidin, Pentosalen). Group: Biochemicals. Alternative Names: 9-[(3-Methyl-2-butenyl)-oxy]-7H-furo[3,2-g][1][benzopyran-7-one; Enoxypsoralen; Marmelosin; Ammidin; Pentosalen. Grades: Highly Purified. CAS No. 482-44-0. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Imperatorin (Pentosalen, Marmelosin, Ammidin, NSC 402949, BAN) | A furanocoumarin isolated from Opopanax chironium L. Displays anticancer properties. It induces apoptosis as well as DNA fragmentation at the G1/S phase of the cell cycle. Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells. Modulator of SMAD1/5/8, p38, ERK pathways. Also acts as a L-type calcium channel blocker. Group: Biochemicals. Alternative Names: 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one. Grades: Highly Purified. CAS No. 482-44-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| Imperialine-D-glucoside | Imperialine-D-glucoside is an alkaloid from Petilium eduardii (Liliaceae). Synonyms: Edpetiline. Grades: >98%. CAS No. 32685-93-1. Molecular formula: C33H53NO8. Mole weight: 591.77582. | |
| Importazole | Importazole is a cell-permeable inhibitor of importin-&beta. Importazole specifically inhibits the function of importin-β, likely by altering its interaction with RanGTP. Synonyms: N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine; Importazole, Importazole hydrochloride, Importazole HCl. CAS No. 662163-81-7. Molecular formula: C20H22N4. Mole weight: 318.42. | |
| Importazole | Importazole is a small molecule inhibitor of the nuclear transport receptor importin-&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 662163-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101091. | |
| Importazole | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Importazole (IPZ, N-(1-Phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine, Importin-b Inhibitor) | A cell-permeable diaminoquinazoline compound that selectively blocks importin-b-mediated nuclear import of NLS- (nuclear localization signal) bearing cargos (IC50=15uM against Ca+2-induced NFAT nuclear import in HEK293 cells) in a reversible manner without affecting transportin-dependent nuclear import of M9 signal-containing cargos or CRM1-mediated nuclear export. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. | Worldwide |
| Imported loaded nano-gold particles graphene | Imported loaded nano-gold particles graphene. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-44. Alfa Chemistry ISO 9001:2015 Certified. | |
| Imported loaded nano-Palladium particles graphene | Imported loaded nano-Palladium particles graphene. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-217. Alfa Chemistry ISO 9001:2015 Certified. | |
| Imported Reduced Graphene Oxide@ Fe3O4 | Imported Reduced Graphene Oxide@ Fe3O4. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-256. Alfa Chemistry ISO 9001:2015 Certified. | |
| Importin ?1 human | ?80% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| IMP-specific 5'-nucleotidase | The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+. Group: Enzymes. Synonyms: ISN1 (gene name). Enzyme Commission Number: EC 3.1.3.99. CAS No. 9027-73-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3706; IMP-specific 5'-nucleotidase; EC 3.1.3.99; 9027-73-0; ISN1 (gene name). Cat No: EXWM-3706. | |
| Impurity C of Alfacalcidol | Cas No. 82266-85-1. | |
| Impurity of exatecan | It is an impurity of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: (1R, 9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1, 2, 3, 9, 12, 15-hexahydro-10H, 13H-benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-10, 13-dione methanesulfonate (1:1); 10H, 13H-Benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-10, 13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1R,9S)-, methanesulfonate (1:1) (salt). Grades: ≥95%. CAS No. 2231666-58-1. Molecular formula: C25H26FN3O7S. Mole weight: 531.55. | |
| IMR-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IMR-1 | IMR-1 is a small-molecule inhibitor of Mastermind Recruitment-1. IMR-1 inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1; IMR 1; IMR1. Inhibitor of Mastermind Recruitment-1; ethyl 2-[2-methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate. Grades: >98%. CAS No. 310456-65-6. Molecular formula: C15H15NO5S2. Mole weight: 353.407. | |
| IMR-1 | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC 50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 310456-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431. | |
| IMR-1A | IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC 50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331862-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431A. | |
| IMR-1A | IMR-1A is a metabolite of IMR-1, and exhibits similar properties as IMR-1. IMR-1A inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1A; IMR 1A; IMR1A; Inhibitor of Mastermind Recruitment-1 Acid; 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid. CAS No. 331862-41-0. Molecular formula: C13H11NO5S2. Mole weight: 325.353. | |
| Imraldi | | |
| Imrecoxib | Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 ( COX-2 ) inhibitor with an IC 50 value of 18 nM, it also inhibits COX1- activity with an IC 50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAP-909. CAS No. 395683-14-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-114200. | |
| IMS | IMS. Group: Biochemicals. Alternative Names: Industrial methylated spirits; Denatured ethanol; Methylated spirits. Grades: Highly Purified. CAS No. 64-17-5. Pack Sizes: 5kg, 10kg, 25kg, 50kg, 100kg. US Biological Life Sciences. | Worldwide |
| IMS2186 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| IMS2186 | IMS2186 is an anti-choroidal neovascularization (CNV) agent that inhibits angiogenesis upstream of VEGF. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031206-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101990. | |
| IMS 2186 | IMS 2186 is an anti-proliferative and anti-angiogenic compound developed as an anti-choroidal neovascularization (anti-CNV) drug. It inhibits the cell cycle at G2 and the production of PGE2/TNF-&alpha. Uses: Anti-cnv drug. Synonyms: IMS2186; IMS-2186; 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one. Grades: 99%. CAS No. 1031206-36-6. Molecular formula: C18H16O4. Mole weight: 296.32. | |
| Imsidolimab | Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti- IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ANB 019. CAS No. 2102543-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99659. | |
| IN01001 | INO1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. It inhibits PARP and results in inhibition of tumor cell DNA repair mechanisms. It has tumor cell resistance and may be used to chemotherapy and radiation therapy. Uses: Ino1001 has tumor cell resistance and may be used to chemotherapy and radiation therapy. Synonyms: IN01001; IN 01001; IN-01001; N-(3-morpholin-4-ylpropyl)-5-oxo-6,11-dihydroindeno[1,2-c]isoquinoline-9-sulfonamide;INO-1001;5H-Indeno[1,2-c]isoquinoline-9-sulfonaMide, 6,11-dihydro-N-[3-(4-Morpholinyl)propyl]-5-oxo. Grades: 98%. CAS No. 501364-82-5. Molecular formula: C23H25N3O4S. Mole weight: 439.53. | |
| IN-1130 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IN-1130 | IN-1130 is a selective ALK5 inhibitor with >100 fold selectivity over p38α and a panel of 26 other serine/threonine and tyrosine kinases. It also inhibit phosphorylation of Smad-2 with an IC50 value of 36 nM. IN-1130 is a suppressor of fibrogenic process of unilateral ureteral obstruction in rats underscoring the potential clinical benefits in the treatment of renal fibrosis. It can also inhibit cancer metastasis in MMTV/c-Neu breast cancer mice, and enhance CTL response in cancer mice. Preclinical clinical research for Cancer and Fibrosis is on-going. Uses: Cancer; connective tissue disorders; fibrosis. Synonyms: IN-1130; IN1130; IN 1130. 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl) methyl)benzamide. Grades: 98%. CAS No. 868612-83-3. Molecular formula: C25H20N6O. Mole weight: 420.47. | |
| In2Se3 Crystal | In2Se3 Crystal. Uses: Designed for use in research and industrial production. Additional or Alternative Names: indiumselenide(in2se3);INDIUM(III) SELENIDE;INDIUM SELENIDE;diindium triselenide;INDIUM(III) SELENIDE, LUMPS;Indium(III) Selenide, Lump;Indium(III) selenide, 99.99% (metals basis);Indium selenide/ 99.999%. Product Category: Graphene-like Materials Series. CAS No. 12056-07-4. Molecular formula: In2Se3. Mole weight: 466.52. Purity: 0.99995. IUPACName: indium(3+); selenium(2-). Density: 5.67 g/mL at 25ºC(lit.). Product ID: ACM12056074. Alfa Chemistry ISO 9001:2015 Certified. | |
| Inabenfide | analytical standard. Group: Pesticides & metabolites standardspesticides & metabolitespesticides & metabolites. | |
| Inactivated Enterococcus faecalis | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Escherichia coli | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Porphyromonas gingivalis | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/vial. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Proteus mirabilis | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Proteus vulgaris | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/mL. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Pseudomonas aeruginosa | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Salmonella enterica | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactone | Inactone is a bioactive molecule of 3-glutarimidyl group that inhibits large ribosomal subunit. CAS No. 487-34-3. Molecular formula: C15H21NO4. Mole weight: 279.33. | |
| Inakalant | Inakalant. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INAKALANT. Product Category: Heterocyclic Organic Compound. CAS No. 335619-18-6. Molecular formula: C23H34N4O5. Mole weight: 446.545. Purity: 0.96. IUPACName: tert-butyl N-[2-[3-[3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]ethyl]carbamate. Product ID: ACM335619186. Alfa Chemistry ISO 9001:2015 Certified. Categories: Isa Kalantari. | |
| Inarigivir | Inarigivir is a dinucleotide prodrug with antiviral and immunomodulatory activity, which has the potential for the treatment of HBV infections. Synonyms: ORI-9020; SB-9000. Grades: 99.20%. CAS No. 475650-36-3. Molecular formula: C20H26N7O10PS. Mole weight: 587.50. | |
| Inarigivir ammonium | Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORI-9020 ammonium; SB-9000 ammonium. CAS No. 2172788-92-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101954A. | |
| Inauhzin | Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice. Synonyms: Inauhzin. Grades: 0.98. CAS No. 309271-94-1. Molecular formula: C25H19N5OS2. Mole weight: 469.58. | |
| Inauhzin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Inavolisib | Inavolisib Inhibitor. Uses: Scientific use. Product Category: T15375. CAS No. 2060571-02-8. | |
| Inavolisib | Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor ( IC 50 =0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3K&alpha. Inavolisib can be used for the study of breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0077; RG6114. CAS No. 2060571-02-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101562. | |
| Inaxaplin | Inaxaplin (VX-147) is an orally active apolipoprotein L1 ( APOL1 ) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-147. CAS No. 2446816-88-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132820. | |
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