A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Trypsin hydrolyzes proteins, peptides, amides and esters specifically at the carboxyl groups of the basic amino acids L-arginine or L-lysine. G3m: 25 ug trypsin per CR-column, immobilized on dextran. 260 ST-units immobilized per CR-column. This CR-column cuts at least 50 ug tubulin per application. Nr. 15 Storage buffer: 50 mM Tris/HCl at pH 8. 0Nr. 67 Reaction buffer: 50 mM phosphate at pH 8. 0 (S?rensen)Nr. 68 Washing buffer: 50 mM phosphate at pH 8. 0, 1 M NaCl. Group: Enzymes. Synonyms: α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin. Enzyme Commission Number: EC 3. 4. 21. 4. Storage: 4 °C. Source: Bovine pancreas. α-trypsin; β-trypsin; cocoonase; parenzyme; parenzymol; tryptar; trypure; pseudotrypsin; tryptase; tripcellim; sperm receptor hydrolase; Alpha-trypsin; Beta-trypsin; EC 3. 4. 21. 4; Trypsin; Immobilized TPCK-Trypsin; Immobilized Trypsin; TPCK-Trypsin. Cat No: NATE-1772.
Immobilized Trypsin, TPCK Treated (Agarose Resin)
Trypsin immobilized on beaded agarose makes it possible to eliminate enzyme contamination of tryptic digests. The trypsin can be easily removed from the digest by separating the trypsin gel from the digestion solution. The Thermo Scientific Immobilized TPCK Trypsin is treated with L-1-tosylamido-2-phenylethyl chloromethyl ketone (TPCK), which is a reagent that has been reported to inhibit chymotrypsin activity without effect on trypsin. Trypsin is a 23,200 molecular weight protein with a pH optimum between 7.5 and 9.0. The isoelectric points of trypsinogen and trypsin are 10.5 and 9.3, respectively. Trypsin has a wide range of applications including amino acid analys...estimated from the number of lysine and arginine residues in the protein. Ionexchange chromatography, paper electrophoresis or peptide mapping can be used to separate digestion fragments. Group: Enzymes. Synonyms: Immobilized Trypsin. Enzyme Commission Number: EC 3.4.21.4. Trypsin. Activity: > 200 TAME units per mL of gel. Storage: Upon receipt store at 4°C. Product is shipped at ambient temperature. Form: 2mL of settled gel supplied as a 50% slurry containing glycerol and 0.05% sodium azide as a preservative. Source: Bovine pancreas. Immobilized Trypsin, TPCK Treated (Agarose Resin); Immobilized Trypsin; Trypsin; Protein Fragmentation Enzymes Kits. Cat No: NATE-1867.
Immunology/Inflammation Compound Library
A unique collection of 3483 anti-inflammation compounds effective for high throughput screening and high content screening. - Bioactivity and safety confirmed by clinical research and trials, some of which are FDA approved; - Detailed compound information with structure, target, activity, IC50 value, and biological activity description; - Structurally diverse, medicinally active, and cell permeable; - NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L4700. Categories: Immunology/Inflammation Compounds Libraries.
Immuno-Oncology Compound Library
A unique collection of 454 compounds acting on immune-oncology therapeutic targets can be used for high throughput and high content screening?- Targets include PD-1/PD-L1, HER2, STAT3, CTLA4, IDO, STING, CCR, CXCR, TLR, etc. - Detailed compound information with structure, target, and biological activity description?- NMR and HPLC validated to ensure high purity and quality. Uses: Scientific use. Product Category: L2170. Categories: Immuno-Oncology Compounds Libraries.
Imofinostat
MPT0E028 is an orally active and selective HDAC inhibitor with IC 50 s of 53.0 nM, 106.2 nM, 29.5 nM for HDAC1, HDAC2 and HDAC6, respectively [1]. MPT0E028 reduces the viability of B-cell lymphomas by inducing apoptosis and possesses potent direct Akt targeting ability and reduces Akt phosphorylation in B-cell lymphoma. MPT0E028 has good anticancer activity [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: MPT0E028. CAS No. 1338320-94-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124295.
Imolamine hydrochloride
Imolamine hydrochloride. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Angolon, Irrigor, Irri-Cor, Imolamine HCl, Imolamine hydrochloride, C14H20N4O.HCl, 318-23-0 (Parent), EINECS 239-920-4, CID27500, LA 1211, LS-99266, Phenyl-3 imino-5 diethylaminoethyl-4 oxadiazol-1,2,4, Phenyl-3 imino-5 diethylaminoethyl-4 oxadiazol-1,2,4 [French], delta(sup 2)-1,2,4-Oxadiazoline, 4-(2-(diethylamino)ethyl)-5-imino-3-phenyl-, monohydrochloride, 1,2,4-Oxadiazole-4(5H)-ethanimine, N,N-diethyl-5-imino-3-phenyl-, monohydrochloride, 1,2,4-Oxadiazole-4(5H)-ethanimine, N,N-diethyl-5-imino-3-phenyl-, monohydrochloride (9CI), 15823-89-9, delta(sup 2)-1,2,4-Oxadiazoline, 4-(2-(diethylamino)ethyl)-5-imino-3-phenyl-,monohydrochloride. Product Category: Heterocyclic Organic Compound. CAS No. 15823-89-9. Molecular formula: C14H20N4O.HCl. Mole weight: 296.796 g/mol. Purity: 0.96. IUPACName: diethyl-[2-(5-imino-3-phenyl-1,2,4-oxadiazol-4-yl)ethyl]azanium chloride. Canonical SMILES: CC[NH+](CC)CCN1C(=NOC1=N)C2=CC=CC=C2.[Cl-]. Density: 1.13g/cm³. ECNumber: 239-920-4. Product ID: ACM15823899. Alfa Chemistry ISO 9001:2015 Certified.
IMP-1088
IMP-1088 is a potent human N-myristoyltransferases NMT1 and NMT2 dual inhibitor with IC50s of <1 nM for HsNMT1 and HsNMT2. IMP-1088 has a Kd of <210 pM for HsNMT1. IMP-1088 efficiently blocks rhinovirus replication by blocking rhinovirus virus-encoded protein (VP0) N-myristoylation. IMP-1088 protects host cells from the cytotoxic effects of viral infection[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2059148-82-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112258.
IMP-1710
IMP-1710 is a potent and selective deubiquitylating enzyme UCHL1 inhibitor with an IC50 value of 38 nM. IMP-1710 has antifibrotic activity. IMP-1710 is a UCHL1 probe to identify and quantify target proteins in intact human cells[1]. IMP-1710 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. IMP-1710 can be used in the research of idiopathic pulmonary fibrosis[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2383117-96-0. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-138995.
IMP2-IN-1
IMP2-IN-1 (compound 4) is a potent IMP2 inhibitor with IC50 value of 81.3~127.5 for IMP2 RNA sequence. IMP2-IN-1 reduces IMP2 in SW480 cells. IMP2-IN-1 significantly reduces the viability of both differentiated and non-differentiated Huh7 cells[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1480482-51-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-146178.
IMP cyclohydrolase
This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in cyclic amidines. The systematic name of this enzyme class is IMP 1,2-hydrolase (decyclizing). Other names in common use include inosinicase, and inosinate cyclohydrolase. This enzyme catalyses the cyclisation of 5-formylamidoimidazole-4-carboxamide ribonucleotide to IMP, a reaction which is important in de novo purine biosynthesis in archaeal species. Group: Enzymes. Synonyms: inosinicase; inosinate cyclohydrolase; IMP 1,2-hydrolase (decyclizing). Enzyme Commission Number: EC 3.5.4.10. CAS No. 9013-81-4. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-4537; IMP cyclohydrolase; EC 3.5.4.10; 9013-81-4; inosinicase; inosinate cyclohydrolase; IMP 1,2-hydrolase (decyclizing). Cat No: EXWM-4537.
IMP dehydrogenase
The enzyme acts on the hydroxy group of the hydrated derivative of the substrate. Group: Enzymes. Synonyms: inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase. Enzyme Commission Number: EC 1.1.1.205. CAS No. 9028-93-7. IMPDH2. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0109; IMP dehydrogenase; EC 1.1.1.205; 9028-93-7; inosine-5'-phosphate dehydrogenase; inosinic acid dehydrogenase; inosinate dehydrogenase; inosine 5'-monophosphate dehydrogenase; inosine monophosphate dehydrogenase; IMP oxidoreductase; inosine monophosphate oxidoreductase. Cat No: EXWM-0109.
Impentamine dihydrobromide
Impentamine dihydrobromide. Group: Biochemicals. Grades: Purified. CAS No. 149629-70-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Imperatorin
Imperatorin is an effective of NO synthesis inhibitor ( IC 50 =9.2 μmol), which also is a BChE inhibitor ( IC 50 =31.4 μmol). Imperatorin is a weak agonist of TRPV1 with EC 50 of 12.6±3.2 μM. Uses: Scientific research. Group: Natural products. Alternative Names: Ammidin. CAS No. 482-44-0. Pack Sizes: 10 mM * 1 mL; 25 mg; 50 mg; 100 mg. Product ID: HY-N0285.
Imperatorin isolated from the root of Angelica dahurica Benth. et Hook. It can suppress multidrug-resistant human liver cancer growth in vivo by inducing Mcl-1 degradation. Imperatorin can be used in health products. Uses: Anti-hiv; anticonvulsant; anti-inflammatory; antimicrobial. Synonyms: 9-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g]chromen-7-one; Imperatorin; Pentosalen; Ammidin; Marmelosin. Grade: 98%. CAS No. 482-44-0. Molecular formula: C16H14O4. Mole weight: 270.3.
Imperatorin
Imperatorin. Group: Biochemicals. Alternative Names: 9-[(3-Methyl-2-buten-1-yl)oxy]-7H-furo[3,2-g][1]benzopyran-7-one; Ammidin. Grades: Highly Purified. CAS No. 482-44-0. Pack Sizes: 25mg, 50mg, 100mg, 250mg, 500mg. Molecular Formula: C16H14O4. US Biological Life Sciences.
A furanocoumarin isolated from Opopanax chironium L. Displays anticancer properties. It induces apoptosis as well as DNA fragmentation at the G1/S phase of the cell cycle. Imperatorin sensitizes anoikis and inhibits anchorage-independent growth of lung cancer cells. Modulator of SMAD1/5/8, p38, ERK pathways. Also acts as a L-type calcium channel blocker. Group: Biochemicals. Alternative Names: 9-(3-methylbut-2-enoxy)furo[3,2-g]chromen-7-one. Grades: Highly Purified. CAS No. 482-44-0. Pack Sizes: 5mg, 25mg. US Biological Life Sciences.
Worldwide
Imperialine
Imperialine is an isosteroidal alkaloid from Fritillaria thunbergii, a short-acting selective M2 muscarinic receptor antagonist. Synonyms: Sipeimine; Raddeamine; (3-beta,5-alpha,17-beta)-3,20-dihydroxycevan-6-one; 3,20-dihydroxy-,(3-beta,5-alpha,17-beta)-cevan-6-on; kashmirine; (5α,17β)-3β,20-Dihydroxycevan-6-one. Grade: 97% (HPLC). CAS No. 61825-98-7. Molecular formula: C27H43NO3. Mole weight: 429.64.
Importazole
Importazole is a small molecule inhibitor of the nuclear transport receptor importin-&beta. Uses: Scientific research. Group: Signaling pathways. CAS No. 662163-81-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg; 200 mg. Product ID: HY-101091.
A cell-permeable diaminoquinazoline compound that selectively blocks importin-b-mediated nuclear import of NLS- (nuclear localization signal) bearing cargos (IC50=15uM against Ca+2-induced NFAT nuclear import in HEK293 cells) in a reversible manner without affecting transportin-dependent nuclear import of M9 signal-containing cargos or CRM1-mediated nuclear export. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
Imported loaded nano-gold particles graphene
Imported loaded nano-gold particles graphene. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-44. Alfa Chemistry ISO 9001:2015 Certified.
Imported loaded nano-Palladium particles graphene
Imported loaded nano-Palladium particles graphene. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-217. Alfa Chemistry ISO 9001:2015 Certified.
Imported Reduced Graphene Oxide@ Fe3O4
Imported Reduced Graphene Oxide@ Fe3O4. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-256. Alfa Chemistry ISO 9001:2015 Certified.
Importin ?1 human
?80% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy.
IMP-specific 5'-nucleotidase
The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+. Group: Enzymes. Synonyms: ISN1 (gene name). Enzyme Commission Number: EC 3.1.3.99. CAS No. 9027-73-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3706; IMP-specific 5'-nucleotidase; EC 3.1.3.99; 9027-73-0; ISN1 (gene name). Cat No: EXWM-3706.
IMR-1
IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC 50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 310456-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431.
IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC 50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331862-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431A.
Imrecoxib
Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 ( COX-2 ) inhibitor with an IC 50 value of 18 nM, it also inhibits COX1- activity with an IC 50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAP-909. CAS No. 395683-14-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-114200.
IMS
IMS. Group: Biochemicals. Alternative Names: Industrial methylated spirits; Denatured ethanol; Methylated spirits. Grades: Highly Purified. CAS No. 64-17-5. Pack Sizes: 5kg, 10kg, 25kg, 50kg, 100kg. US Biological Life Sciences.
IMS2186 is an anti-choroidal neovascularization (CNV) agent that inhibits angiogenesis upstream of VEGF. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031206-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101990.
Imsidolimab
Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti- IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ANB 019. CAS No. 2102543-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99659.
IMT1
IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304621-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134539.
IMT1B
IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDC203974. CAS No. 2304621-06-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-137067.
IN-1130
IN-1130 is a highly selective transforming growth factor-? type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38? mitogen-activated protein kinase (IC50=4.3 ?M). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 868612-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18758.
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy.
Inactivated Escherichia coli
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy.
Inactivated Porphyromonas gingivalis
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/vial. Group: Fluorescence/luminescence spectroscopy.
Inactivated Proteus mirabilis
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy.
Inactivated Proteus vulgaris
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/mL. Group: Fluorescence/luminescence spectroscopy.
Inactivated Pseudomonas aeruginosa
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy.
Inactivated Salmonella enterica
Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy.
Inactive hydroxysteroid dehydrogenase-like protein 1 (20-27)
A peptide fragment of Inactive hydroxysteroid dehydrogenase-like protein 1. Inactive hydroxysteroid dehydrogenase-like protein 1 belongs to the SDR family.
Inactone
Inactone is a bioactive molecule of 3-glutarimidyl group that inhibits large ribosomal subunit. CAS No. 487-34-3. Molecular formula: C15H21NO4. Mole weight: 279.33.
Inakalant
Inakalant. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INAKALANT. Product Category: Heterocyclic Organic Compound. CAS No. 335619-18-6. Molecular formula: C23H34N4O5. Mole weight: 446.545. Purity: 0.96. IUPACName: tert-butyl N-[2-[3-[3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]ethyl]carbamate. Product ID: ACM335619186. Alfa Chemistry ISO 9001:2015 Certified. Categories: Isa Kalantari.
Inarigivir ammonium
Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORI-9020 ammonium; SB-9000 ammonium. CAS No. 2172788-92-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101954A.
Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor ( IC 50 =0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3K&alpha. Inavolisib can be used for the study of breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0077; RG6114. CAS No. 2060571-02-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101562.
Inaxaplin
Inaxaplin (VX-147) is an orally active apolipoprotein L1 ( APOL1 ) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-147. CAS No. 2446816-88-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132820.
Inbakicept
Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2135939-52-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99661.
INCA-6
INCA-6. Group: Biochemicals. Grades: Purified. CAS No. 3519-82-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
Incadronic acid
Incadronic acid inhibits growth of Dictyostelium discoideum with an IC 50 of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase ( FPPS ) in Leishmania major with the K i of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC 50 of 48 to 228.6 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 124351-85-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-149149.
INCB024360
INCB024360. Group: Biochemicals. Alternative Names: (E)-4-amino-N-(3-Chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide. Grades: Highly Purified. CAS No. 914471-09-3. Pack Sizes: 25mg. US Biological Life Sciences.
Worldwide
INCB054329
INCB054329 is a potent BET inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628607-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112504.
INCB-057643
INCB-057643 is a novel, orally bioavailable BET inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820889-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111485.
INCB086550
INCB086550 is A Potent and Novel Small-Molecule PD-L1 Inhibitor. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INCB086550; INCB-086550; INCB 086550; INCB86550; INCB-86550; INCB 86550; PD-1; PD-L1-IN-8. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2230911-59-6. Molecular formula: C41H39N7O4. Mole weight: 693.81. Purity: >98%. IUPACName: 1-((7-cyano-2-(3'-((3-((3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-yl)amino)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid. Canonical SMILES: CC1=C(C=CC=C1C2=NC3=CC(=CC(=C3O2)C#N)CN4CCC(C4)C(=O)O)C5=C(C(=CC=C5)NC6=NC=CC7=CC(=CN=C76)CN8CCC(C8)O)C. Product ID: ACM2230911596. Alfa Chemistry ISO 9001:2015 Certified.
INCB086550
INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC 50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD-1/PD-L1-IN-8. CAS No. 2230911-59-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134884.
INCB 3284 dimesylate
INCB 3284 dimesylate. Group: Biochemicals. Grades: Purified. CAS No. 887401-93-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
INCB3344
INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1262238-11-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50674.
Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression [1]. Uses: Scientific research. Group: Natural products. CAS No. 22419-74-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N4097.
Incensole
Incensole. Group: Biochemicals. Grades: Plant Grade. CAS No. 22419-74-5. Pack Sizes: 50mg. Molecular Formula: C20H34O2, Molecular Weight: 306.48. US Biological Life Sciences.
Worldwide
Incensole acetate
Incensole acetate. Group: Biochemicals. Grades: Plant Grade. CAS No. 34701-53-6. Pack Sizes: 50mg. Molecular Formula: C22H36O3, Molecular Weight: 348.52. US Biological Life Sciences.