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| Product | Description | |
|---|---|---|
| Importazole | Importazole is a cell-permeable inhibitor of importin-&beta. Importazole specifically inhibits the function of importin-β, likely by altering its interaction with RanGTP. Synonyms: N-(1-phenylethyl)-2-(pyrrolidin-1-yl)quinazolin-4-amine; Importazole, Importazole hydrochloride, Importazole HCl. CAS No. 662163-81-7. Molecular formula: C20H22N4. Mole weight: 318.42. |  |
| Importazole (IPZ, N-(1-Phenylethyl)-2-pyrrolidin-1-ylquinazolin-4-amine, Importin-b Inhibitor) | A cell-permeable diaminoquinazoline compound that selectively blocks importin-b-mediated nuclear import of NLS- (nuclear localization signal) bearing cargos (IC50=15uM against Ca+2-induced NFAT nuclear import in HEK293 cells) in a reversible manner without affecting transportin-dependent nuclear import of M9 signal-containing cargos or CRM1-mediated nuclear export. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 10mg. US Biological Life Sciences. |  Worldwide |
| Imported loaded nano-gold particles graphene | Imported loaded nano-gold particles graphene. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-44. Alfa Chemistry ISO 9001:2015 Certified. |  |
| Imported loaded nano-Palladium particles graphene | Imported loaded nano-Palladium particles graphene. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-217. Alfa Chemistry ISO 9001:2015 Certified. | |
| Imported Reduced Graphene Oxide@ Fe3O4 | Imported Reduced Graphene Oxide@ Fe3O4. Uses: Designed for use in research and industrial production. Product Category: Graphene With High Quality. CAS No. 7440-44-0. Product ID: ACM7440440-256. Alfa Chemistry ISO 9001:2015 Certified. | |
| Importin ?1 human | ?80% (SDS-PAGE), recombinant, expressed in E. coli (N-terminal histidine tagged), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. |  |
| IMP-specific 5'-nucleotidase | The enzyme, isolated from the yeast Saccharomyces cerevisiae, is highly specific for inosine 5'-phosphate, and has no detectable activity with other purine and pyrimidine nucleotides. Requires divalent metals, such as Mg2+, Co2+ or Mn2+. Group: Enzymes. Synonyms: ISN1 (gene name). Enzyme Commission Number: EC 3.1.3.99. CAS No. 9027-73-0. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3706; IMP-specific 5'-nucleotidase; EC 3.1.3.99; 9027-73-0; ISN1 (gene name). Cat No: EXWM-3706. |  |
| Impurity C of Alfacalcidol | Cas No. 82266-85-1. | |
| Impurity of exatecan | It is an impurity of Exatecan, which is a DNA topoisomerase I inhibitor used to study cancer. Synonyms: (1R, 9S)-1-Amino-9-ethyl-5-fluoro-9-hydroxy-4-methyl-1, 2, 3, 9, 12, 15-hexahydro-10H, 13H-benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-10, 13-dione methanesulfonate (1:1); 10H, 13H-Benzo[de]pyrano[3', 4':6, 7]indolizino[1, 2-b]quinoline-10, 13-dione, 1-amino-9-ethyl-5-fluoro-1,2,3,9,12,15-hexahydro-9-hydroxy-4-methyl-, (1R,9S)-, methanesulfonate (1:1) (salt). Grades: ≥95%. CAS No. 2231666-58-1. Molecular formula: C25H26FN3O7S. Mole weight: 531.55. | |
| IMR-1 | IMR-1 is a small-molecule inhibitor of Mastermind Recruitment-1. IMR-1 inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1; IMR 1; IMR1. Inhibitor of Mastermind Recruitment-1; ethyl 2-[2-methoxy-4-[(Z)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetate. Grades: >98%. CAS No. 310456-65-6. Molecular formula: C15H15NO5S2. Mole weight: 353.407. | |
| IMR-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IMR-1 | IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC 50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 310456-65-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431. |  |
| IMR-1A | IMR-1A is a metabolite of IMR-1, and exhibits similar properties as IMR-1. IMR-1A inhibits Notch target gene transcription via disrupting recruitment of Mastermind 1 to the Notch transcriptional activation complex on chromatin, thereby suppressing tumor growth. Synonyms: IMR-1A; IMR 1A; IMR1A; Inhibitor of Mastermind Recruitment-1 Acid; 2-[2-methoxy-4-[(E)-(4-oxo-2-sulfanylidene-1,3-thiazolidin-5-ylidene)methyl]phenoxy]acetic acid. CAS No. 331862-41-0. Molecular formula: C13H11NO5S2. Mole weight: 325.353. | |
| IMR-1A | IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC 50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 331862-41-0. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100431A. | |
| Imraldi | | |
| Imrecoxib | Imrecoxib (BAP-909) is a novel and selective cyclooxygenase 2 ( COX-2 ) inhibitor with an IC 50 value of 18 nM, it also inhibits COX1- activity with an IC 50 value of 115 nM. Imrecoxib (BAP-909) has anti-inflammatory effect [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BAP-909. CAS No. 395683-14-4. Pack Sizes: 10 mM * 1 mL; 50 mg; 100 mg. Product ID: HY-114200. | |
| IMS | IMS. Group: Biochemicals. Alternative Names: Industrial methylated spirits; Denatured ethanol; Methylated spirits. Grades: Highly Purified. CAS No. 64-17-5. Pack Sizes: 5kg, 10kg, 25kg, 50kg, 100kg. US Biological Life Sciences. | Worldwide |
| IMS2186 | IMS2186 is an anti-choroidal neovascularization (CNV) agent that inhibits angiogenesis upstream of VEGF. IMS2186 can arrest cancer cell cycle in G2/M phase, thus exerting anti-proliferation and anti-angiogenesis effects. IMS2186 has no intraocular toxicity and reduces the amount of eye leakage and diseased cells [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1031206-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-101990. | |
| IMS2186 | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| IMS 2186 | IMS 2186 is an anti-proliferative and anti-angiogenic compound developed as an anti-choroidal neovascularization (anti-CNV) drug. It inhibits the cell cycle at G2 and the production of PGE2/TNF-&alpha. Uses: Anti-cnv drug. Synonyms: IMS2186; IMS-2186; 3-[1-(3-Hydroxy-4-methoxyphenyl)-meth-(E)-ylidene]-6-methyl-chroman-4-one. Grades: 99%. CAS No. 1031206-36-6. Molecular formula: C18H16O4. Mole weight: 296.32. | |
| Imsidolimab | Imsidolimab (ANB 019) is a high-affinity, humanized monoclonal antibody of anti- IL-36R. Imsidolimab antagonizes IL-36 cytokine signal transduction. Imsidolimab has potential application in generalized pustular psoriasis (GPP) and other inflammatory skin diseases [1] [2]. Uses: Scientific research. Group: Inhibitory antibodies. Alternative Names: ANB 019. CAS No. 2102543-86-0. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99659. | |
| IMT1 | IMT1 is a first-in-class specific and noncompetitive human mitochondrial RNA polymerase (POLRMT) inhibitor. IMT1 causes a conformational change of POLRMT, which blocks substrate binding and transcription in a dose-dependent way in vitro. IMT1 reduces deoxynucleoside triphosphate levels and citric acid cycle intermediates, resulting in a marked depletion of cellular amino acid levels. IMT1 has the potential for mitochondrial transcription disorders related diseases[1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2304621-31-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134539. | |
| IMT1B | IMT1B (LDC203974) is an orally active, noncompetitive and specific allosteric inhibitor of mitochondrial RNA polymerase (POLRMT) and inhibits mitochondrial DNA (mtDNA) expression. IMT1B has anti-tumour effects[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: LDC203974. CAS No. 2304621-06-3. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-137067. | |
| IN01001 | INO1001 is an isoindolinone derivative and potent inhibitor of the nuclear enzyme poly (ADP-ribose) polymerase (PARP) with chemosensitization and radiosensitization properties. It inhibits PARP and results in inhibition of tumor cell DNA repair mechanisms. It has tumor cell resistance and may be used to chemotherapy and radiation therapy. Uses: Ino1001 has tumor cell resistance and may be used to chemotherapy and radiation therapy. Synonyms: IN01001; IN 01001; IN-01001; N-(3-morpholin-4-ylpropyl)-5-oxo-6,11-dihydroindeno[1,2-c]isoquinoline-9-sulfonamide;INO-1001;5H-Indeno[1,2-c]isoquinoline-9-sulfonaMide, 6,11-dihydro-N-[3-(4-Morpholinyl)propyl]-5-oxo. Grades: 98%. CAS No. 501364-82-5. Molecular formula: C23H25N3O4S. Mole weight: 439.53. | |
| IN-1130 | IN-1130 is a highly selective transforming growth factor-? type I receptor kinase (ALK5) inhibitor with an IC50 of 5.3 nM for ALK5-mediated Smad3 phosphorylation. IN-1130 inhibits ALK5 phosphorylation of casein (IC50=36 nM) and p38? mitogen-activated protein kinase (IC50=4.3 ?M). IN-1130 suppresses renal fibrosis in obstructive nephropathy and blocks breast cancer lung metastasis[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 868612-83-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-18758. | |
| IN-1130 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IN-1130 | IN-1130 is a selective ALK5 inhibitor with >100 fold selectivity over p38α and a panel of 26 other serine/threonine and tyrosine kinases. It also inhibit phosphorylation of Smad-2 with an IC50 value of 36 nM. IN-1130 is a suppressor of fibrogenic process of unilateral ureteral obstruction in rats underscoring the potential clinical benefits in the treatment of renal fibrosis. It can also inhibit cancer metastasis in MMTV/c-Neu breast cancer mice, and enhance CTL response in cancer mice. Preclinical clinical research for Cancer and Fibrosis is on-going. Uses: Cancer; connective tissue disorders; fibrosis. Synonyms: IN-1130; IN1130; IN 1130. 3-((5-(6-Methylpyridin-2-yl)-4-(quinoxalin-6-yl)-1H-imidazol-2-yl) methyl)benzamide. Grades: 98%. CAS No. 868612-83-3. Molecular formula: C25H20N6O. Mole weight: 420.47. | |
| In2Se3 Crystal | In2Se3 Crystal. Uses: Designed for use in research and industrial production. Additional or Alternative Names: indiumselenide(in2se3);INDIUM(III) SELENIDE;INDIUM SELENIDE;diindium triselenide;INDIUM(III) SELENIDE, LUMPS;Indium(III) Selenide, Lump;Indium(III) selenide, 99.99% (metals basis);Indium selenide/ 99.999%. Product Category: Graphene-like Materials Series. CAS No. 12056-07-4. Molecular formula: In2Se3. Mole weight: 466.52. Purity: 0.99995. IUPACName: indium(3+); selenium(2-). Density: 5.67 g/mL at 25ºC(lit.). Product ID: ACM12056074. Alfa Chemistry ISO 9001:2015 Certified. | |
| Inabenfide | analytical standard. Group: Pesticides & metabolites standardspesticides & metabolitespesticides & metabolites. | |
| Inactivated Enterococcus faecalis | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Escherichia coli | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Porphyromonas gingivalis | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/vial. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Proteus mirabilis | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Proteus vulgaris | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/mL. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Pseudomonas aeruginosa | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactivated Salmonella enterica | Suitable for DNA extraction, PCR, sequencing, next generation sequencing, >10^8 bacteria/ml. Group: Fluorescence/luminescence spectroscopy. | |
| Inactone | Inactone is a bioactive molecule of 3-glutarimidyl group that inhibits large ribosomal subunit. CAS No. 487-34-3. Molecular formula: C15H21NO4. Mole weight: 279.33. | |
| Inakalant | Inakalant. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INAKALANT. Product Category: Heterocyclic Organic Compound. CAS No. 335619-18-6. Molecular formula: C23H34N4O5. Mole weight: 446.545. Purity: 0.96. IUPACName: tert-butyl N-[2-[3-[3-(4-cyanophenoxy)-2-hydroxypropyl]-9-oxa-3,7-diazabicyclo[3.3.1]nonan-7-yl]ethyl]carbamate. Product ID: ACM335619186. Alfa Chemistry ISO 9001:2015 Certified. Categories: Isa Kalantari. | |
| Inarigivir | Inarigivir is a dinucleotide prodrug with antiviral and immunomodulatory activity, which has the potential for the treatment of HBV infections. Synonyms: ORI-9020; SB-9000. Grades: 99.20%. CAS No. 475650-36-3. Molecular formula: C20H26N7O10PS. Mole weight: 587.50. | |
| Inarigivir ammonium | Inarigivir (ORI-9020) ammonium is a dinucleotide antiviral drug that can significantly reduce liver HBV DNA in transgenic mice expressing hepatitis B virus. Inarigivir (ORI-9020) ammonium acts as a RIG-I (Retinoic acid-inducible gene-I) agonist to activate cellular innate immune responses [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ORI-9020 ammonium; SB-9000 ammonium. CAS No. 2172788-92-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101954A. | |
| Inauhzin | Inauhzin is a potent SIRT inhibitor, which effectively reactivates p53 by inhibiting SIRT1 activity, promotes p53-dependent apoptosis of human cancer cells without causing apparently genotoxic stress. Moreover, Inauhzin stabilizes p53 by increasing p53 acetylation and preventing MDM2-mediated ubiquitylation of p53 in cells, though not directly in vitro. Remarkably, Inauhzin inhibits cell proliferation, induces senescence and tumour-specific apoptosis, and represses the growth of xenograft tumours derived from p53-harbouring H460 and HCT116 cells without causing apparent toxicity to normal tissues and the tumour-bearing SCID mice. Synonyms: Inauhzin. Grades: 0.98. CAS No. 309271-94-1. Molecular formula: C25H19N5OS2. Mole weight: 469.58. | |
| Inauhzin | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Inavolisib | Inavolisib Inhibitor. Uses: Scientific use. Product Category: T15375. CAS No. 2060571-02-8. |  |
| Inavolisib | Inavolisib (GDC-0077) is a potent, orally active, and selective PI3Kα inhibitor ( IC 50 =0.038 nM). Inavolisib exerts its activity by binding to the ATP binding site of PI3K, thereby inhibiting the phosphorylation of PIP2 to PIP3. Inavolisib is more selective for mutant versus wild-type PI3K&alpha. Inavolisib can be used for the study of breast cancer [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: GDC-0077; RG6114. CAS No. 2060571-02-8. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-101562. | |
| Inaxaplin | Inaxaplin (VX-147) is an orally active apolipoprotein L1 ( APOL1 ) function inhibitor (WO2020131807, compound 2). Inaxaplin can be used for the research of kidney disease [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: VX-147. CAS No. 2446816-88-0. Pack Sizes: 10 mM * 1 mL; 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-132820. | |
| Inaxaplin | Inaxaplin is an apolipoprotein L1 (APOL1) function inhibitor. Synonyms: 3-[5,7-difluoro-2-(4-fluorophenyl)-1H-indol-3-yl]-N-[(3S,4R)-4-hydroxy-2-oxopyrrolidin-3-yl]propanamide; 1H-Indole-3-propanamide, 5,7-difluoro-2-(4-fluorophenyl)-N-[(3S,4R)-4-hydroxy-2-oxo-3-pyrrolidinyl]-. CAS No. 2446816-88-0. Molecular formula: C21H18F3N3O3. Mole weight: 417.38. | |
| Inbakicept | Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells [1]. Uses: Scientific research. Group: Inhibitory antibodies. CAS No. 2135939-52-3. Pack Sizes: 1 mg; 5 mg; 10 mg. Product ID: HY-P99661. | |
| INCA-6 | INCA-6, a cell-permeable quinone compound, is a selective and potent inhibitor of Calcineurin Nuclear Factor of Activated T cells (NFAT) signaling. It binds to calcineurin with high affinity and does not affect calcineurin activity or its downstream signaling. It blocks its dephosphorylation and nuclear import, thus interferes with downstream targets of NFAT including induction of cytokine mRNAs. Synonyms: INCA-6; INCA 6; INCA6; 9,10-Dihydro-9,10-o-benzenoanthracene-1,4-dione; 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione; 1,4-Triptycenoquinone; 12,15-Dihydro-12,15-dioxotriptycene; NSC 25996; Triptycene-1,4-quinone. Grades: ≥98% by HPLC. CAS No. 3519-82-2. Molecular formula: C20H12O2. Mole weight: 284.31. | |
| INCA-6 | INCA-6. Group: Biochemicals. Grades: Purified. CAS No. 3519-82-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| Incadronic acid | Incadronic acid inhibits growth of Dictyostelium discoideum with an IC 50 of 1.6 μM. Incadronic acid binds the farnesyl diphosphate synthase ( FPPS ) in Leishmania major with the K i of 23 nM. Incadronic acid inhibits the bone resorption and reduces bone loss, that can be used in osteoporosis research. Incadronic acid inhibits the proliferation of cells RAW264.7, PC-3 and MCF-7 with IC 50 of 48 to 228.6 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 124351-85-5. Pack Sizes: 1 mg; 5 mg. Product ID: HY-149149. | |
| INCB024360 | INCB024360. Group: Biochemicals. Alternative Names: (E)-4-amino-N-(3-Chloro-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide. Grades: Highly Purified. CAS No. 914471-09-3. Pack Sizes: 25mg. US Biological Life Sciences. | Worldwide |
| INCB024360-analog | Potent competitive inhibitor of IDO1 with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model; This INCB024360-analog decreased kynurenine levels by >50% in plasma and inhibited B16-GM-CSF tumor growth in a dose dependent fashion. Synonyms: INCB-24360; INCB024360; INCB 024360; INCB-024360; indoleamine-2,3-dioxygenase inhibitor INCB024360. Grades: > 98%. CAS No. 914471-09-3. Molecular formula: C9H7ClFN5O2. Mole weight: 271.64. | |
| INCB054329 | INCB054329 is a potent BET inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1628607-64-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-112504. | |
| INCB054329 | INCB054329 is a novel bromodomain and extraterminal domain (BET) inhibitor. It induces vulnerabilities in myeloma cells by inhibition of BET protein. Uses: Antineoplastic agents. Synonyms: INCB-054329; INCB-54329; 7-(3,5-Dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihydroimidazo[1,5,4-de][1,4]benzoxazin-2(1H)-one. CAS No. 1628607-64-6. Molecular formula: C19H16N4O3. Mole weight: 348.36. | |
| INCB057643 | INCB057643 is a bromodomain and extraterminal domain (BET) inhibitor. It binds to the acetylated lysine recognition motifs found in the BRD of BET proteins, thereby preventing the interaction between the BET proteins and acetylated lysines on histones. Synonyms: INCB-057643; 2,2,4-trimethyl-8-(6-methyl-7-oxo-6,7-dihydro-1H-pyrrolo[2,3-c]pyridin-4-yl)-6-(methylsulfonyl)-2H-benzo[b][1,4]oxazin-3(4H)-one. CAS No. 1820889-23-3. Molecular formula: C20H21N3O5S. Mole weight: 415.46. | |
| INCB-057643 | INCB-057643 is a novel, orally bioavailable BET inhibitor. Uses: Scientific research. Group: Signaling pathways. CAS No. 1820889-23-3. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-111485. | |
| INCB086550 | INCB086550 is a potent, oral, small-molecule PD-L1 inhibitor with IC 50s value of 3.1, 4.9 and 1.9 nM for human, cynomolgus, and rat, respectively. INCB086550 promotes the dimerization of cell-surface PD-L1 and induces PD-L1 entry into Golgi vesicles then traffick to the nucleus. INCB086550 can be used for multiple cancers research [1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: PD-1/PD-L1-IN-8. CAS No. 2230911-59-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-134884. | |
| INCB086550 | INCB086550 is A Potent and Novel Small-Molecule PD-L1 Inhibitor. In vitro, INCB086550 selectively and potently blocked the PD-L1/PD-1 interaction, induced PD-L1 dimerization and internalization, and induced stimulation-dependent cytokine production in primary human immune cells. In vivo, INCB086550 reduced tumor growth in CD34+ humanized mice and induced T-cell activation gene signatures, consistent with PD-L1/PD-1 pathway blockade. Preliminary data from an ongoing phase I study confirmed PD-L1/PD-1 blockade in peripheral blood cells, with increased immune activation and tumor growth control. Uses: Designed for use in research and industrial production. Additional or Alternative Names: INCB086550; INCB-086550; INCB 086550; INCB86550; INCB-86550; INCB 86550; PD-1; PD-L1-IN-8. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 2230911-59-6. Molecular formula: C41H39N7O4. Mole weight: 693.81. Purity: >98%. IUPACName: 1-((7-cyano-2-(3'-((3-((3-hydroxypyrrolidin-1-yl)methyl)-1,7-naphthyridin-8-yl)amino)-2,2'-dimethyl-[1,1'-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)pyrrolidine-3-carboxylic acid. Canonical SMILES: CC1=C(C=CC=C1C2=NC3=CC(=CC(=C3O2)C#N)CN4CCC(C4)C(=O)O)C5=C(C(=CC=C5)NC6=NC=CC7=CC(=CN=C76)CN8CCC(C8)O)C. Product ID: ACM2230911596. Alfa Chemistry ISO 9001:2015 Certified. | |
| INCB16562 | INCB16562 is a novel, selective, and orally bioavailable small-molecule inhibitor of JAK1 and JAK2 markedly selective over JAK3. Treatment of myeloma cells with INCB16562 potently inhibited interleukin-6 (IL-6)-induced phosphorylation of STAT3. INCB16562 abrogated the protective effects of recombinant cytokines or bone marrow stromal cells and sensitized myeloma cells to cell death by exposure to dexamethasone, melphalan, or bortezomib. Oral administration of INCB16562 antagonized the growth of myeloma xenografts in mice and enhanced the antitumor activity of relevant agents in combination studies. INCB16562 is a potent JAK1/2 inhibitor and that mitigation of JAK/STAT signaling by targeting JAK1 and JAK2 will be beneficial in the treatment of myeloma patients, particularly in combination with other agents. Synonyms: INCB-16562; INCB 16562; 2-(2,6-dichlorophenyl)-1,8-dihydroimidazo[4,5-d]dipyrido[2,3-b:4',3'-f]azepine. CAS No. 933768-63-9. Molecular formula: C19H11Cl2N5. Mole weight: 380.23. | |
| INCB 3284 | INCB 3284 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM. Synonyms: N-(2-(((R)-1-((1r,4R)-4-hydroxy-4-(6-methoxypyridin-3-yl)cyclohexyl)pyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide dimethanesulfonate; INCB3284; INCB 3284; INCB-3284; INCB3284 mesylate; INCB3284 dimesylate. CAS No. 887401-92-5. Molecular formula: C26H31F3N4O4. Mole weight: 520.54. | |
| INCB 3284 dimesylate | INCB 3284 dimesylate. Group: Biochemicals. Grades: Purified. CAS No. 887401-93-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| INCB 3284 dimesylate | INCB 3284 dimesylate is a potent, selective and orally bioavailable CCR2 antagonist with IC50 of 3.7 nM. Synonyms: INCB 3284 dimesylate; INCB3284 dimesylate; INCB-3284 dimesylate; N-[2-[[(3R)-1-[trans-4-hydroxy-4-(6-methoxy-3-pyridinyl)cyclohexyl]-3-pyrrolidinyl]amino]-2-oxoethyl]-3-(trifluoromethyl)-benzamide, dimethanesulfonate. CAS No. 887401-93-6. Molecular formula: C26H31F3N4O4.2CH4O3S. Mole weight: 712.76. | |
| INCB3344 | INCB3344 is a potent, selective and orally bioavailable CCR2 antagonist with IC50 values of 5.1 nM (hCCR2) and 9.5 nM (mCCR2) in binding antagonism and 3.8 nM (hCCR2) and 7.8 nM (mCCR2) in antagonism of chemotaxis activity. Uses: Scientific research. Group: Signaling pathways. CAS No. 1262238-11-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-50674. | |
| INCB3344 | INCB3344 is a potent CCR2 antagonist with IC50 of 5.1 nM and 9.5 nM for hCCR2 and mCCR2, respectively. Synonyms: INCB3344; INCB 3344; INCB-3344; N-(2-(((3S,4S)-1-(4-(Benzo[d][1,3]dioxol-5-yl)-4-hydroxycyclohexyl)-4-ethoxypyrrolidin-3-yl)amino)-2-oxoethyl)-3-(trifluoromethyl)benzamide. CAS No. 1262238-11-8. Molecular formula: C29H34F3N3O6. Mole weight: 577.59. | |
| INCB-9471 Dihydrochloride | INCB-9471 HCl is an allosteric non-competitive small molecule antagonist of C-C chemokine receptor 5, which has strong inhibitory activity on monocyte migration and HIV-1 infection. Synonyms: Methanone,(4,6-Dimethyl-5-Pyrimidinyl)[4-[(3S)-4-[(1R,2R)-2-Ethoxy-2,3-Dihydro-5-(Trifluoromethyl)-1H-Inden-1-Yl]-3-Methyl-1-Piperazinyl]-4-Methyl-1-Piperidinyl]-,Hydrochloride (1:2). Grades: 98%. CAS No. 869725-27-9. Molecular formula: C30H42Cl2F3N5O2. Mole weight: 632.6. | |
| INCENP, His tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| Incensole | Incensole. Group: Biochemicals. Grades: Plant Grade. CAS No. 22419-74-5. Pack Sizes: 50mg. Molecular Formula: C20H34O2, Molecular Weight: 306.48. US Biological Life Sciences. | Worldwide |
| Incensole | Incensole, a 14-membered diterpenoid, is isolated from both essential oils and resins of frankincense. Incensole has shown anti-inflammatory and anti-depression activities due to their ability to activate ion channels in the brain to alleviate anxiety or depression [1]. Uses: Scientific research. Group: Natural products. CAS No. 22419-74-5. Pack Sizes: 5 mg; 10 mg. Product ID: HY-N4097. | |
| Incensole acetate | Incensole acetate, a Boswellia Resin constituent, is a novel TRPV3 agonist and NF-κB inhibitor. Incensole acetate exhibits anxiolytic and antidepressive properties in wild-type (WT) mice with concomitant changes in c-Fos activation in the brain. Synonyms: GTPL4220; 1,5,9-trimethyl-12-(propan-2-yl)-15-oxabicyclo[10.2.1]pentadeca-5,9-dien-2-yl acetate. CAS No. 34701-53-6. Molecular formula: C22H36O3. Mole weight: 348.52. | |
| Incensole acetate | Incensole acetate. Group: Biochemicals. Grades: Plant Grade. CAS No. 34701-53-6. Pack Sizes: 50mg. Molecular Formula: C22H36O3, Molecular Weight: 348.52. US Biological Life Sciences. | Worldwide |
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