A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
ICA 110381 is a KV7.2/7.3 activator with EC50 value of 0.38 μM. It has anticonvulsive properties in amygdala-kindled rat. It selectively activates human KCNQ2 expressed in Chinese hamster ovary and may be used to study the pharmacological activities. It also decreases neuronal excitability in CA1 hippocampal neurons. Synonyms: ICA 110381; ICA110381; ICA-110381; 4-Chloro-N-(6-chloro-3-pyridinyl)benzamide. Grades: ≥98% by HPLC. CAS No. 325457-99-6. Molecular formula: C12H8Cl2N2O. Mole weight: 267.11.
ICA 110381
ICA 110381. Group: Biochemicals. Grades: Purified. CAS No. 325457-99-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ICA 121431
ICA 121431. Group: Biochemicals. Grades: Purified. CAS No. 313254-51-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ICA-121431
ICA-121431 is a potent and selective inhibitor of human NaV1.3 (IC50=13 nM) and NaV1.1 channels (IC50=23 nM) with 1,000 fold selectivity against other resistant sodium channels like human Nav1.5 or Nav1.7 channels. Synonyms: ICA-121431; ICA 121431; ICA121431. 2,2-diphenyl-N-[4-(1,3-thiazol-2-ylsulfamoyl)phenyl]acetamide2,2-diphenyl-N-(4-(N-thiazol-2-ylsulfamoyl)phenyl)acetamideICA-121431; ICA 121431; ICA121431. CAS No. 313254-51-2. Molecular formula: C23H19N3O3S2. Mole weight: 449.54.
ICA-27243
ICA-27243 is a selective, effective and orally active KCNQ2/Q3 potassium channel opener with EC50 of 0.38 μM. Synonyms: Benzamide, N-(6-Chloro-3-Pyridinyl)-3,4-Difluoro-. Grades: 98%. CAS No. 325457-89-4. Molecular formula: C12H7ClF2N2O. Mole weight: 268.64.
Icapamespib
Icapamespib, also known as PU-HZ 151, is a heat shock protein 90 (HSP90) inhibitor. PU-HZ151 showed EC50 of 5 nM in the FP assay as compared to 11 nM for PU-H71 and a logD of 2.37 as compared to 1.21 for PU-H71. PU-HZ151 and radiolabeled PU-HZ151 showed selectivity for epichaperomes over the individual chaperome members. Icapamespib demonstrated the ability to productively engage the target in cells, mice, and humans. Group: Inhibitors. Alternative Names: Icapamespib; PU-HZ 151; PU-HZ-151; PU-HZ151; PUHZ 151; PUHZ-151; PUHZ151. CAS No. 1000999-96-1. Molecular formula: C19H23IN6O2S. Mole weight: 526.4. Appearance: Solid powder. Purity: >98%. IUPACName: 9-{2-[(2,2-dimethylpropyl)amino]ethyl}-8-[(6-iodo-2H-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-6-amine. Canonical SMILES: NC1=C2N=C (SC3=C (I)C=C (OCO4)C4=C3)N (CCNCC (C) (C)C)C2=NC=N1. Catalog: ACM1000999961.
Icariin
Icariin is a flavonol glycoside. Icariin inhibits PDE5 and PDE4 activities with IC50s of 432 nM and 73.50 μM, respectively. Icariin also is a PPARα activator. Group: Inhibitors. Alternative Names: 4-O-methyl-8-γ, γ-dimethylallylkaempferol-3-rhamnoside-7-glucoside. CAS No. 489-32-7. Molecular formula: C33H40O15. Mole weight: 676.66. Appearance: Light-yellow powder. Purity: 0.98. IUPACName: 5-Hydroxy-2-(4-methoxyphenyl)-8-(3-methylbut-2-enyl)-7-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxychromen-4-one. Canonical SMILES: C[C@H]1[C@@H] ([C@H] ([C@H] ([C@@H] (O1)OC2=C (OC3=C (C2=O)C (=CC (=C3CC=C (C)C)O[C@H]4[C@@H] ([C@H] ([C@@H] ([C@H] (O4)CO)O)O)O)O)C5=CC=C (C=C5)OC)O)O)O. Density: 1.55 g/ml. Catalog: ACM489327.
Icariin
Icariin is a flavonol glycoside and a PDE5 inhibitor (IC50 = 5.9 μM) with 67-fold selectivity for PDE5 over PDE4. It exhibits antioxidant and anticancer activity. At a concentration of 1 x 107 mol/L, Icariin induces differentiation of cardiomyocytes and upregulates the expression of cardiac genes. At 20 μg/ml, Icariin increases the proliferation and differentiation of cultured human osteoblasts. Icariin affects the aging mechanism from different aspects, can delay the aging process and prevent the occurrence of senile diseases. Uses: Ingredient of health care products. Synonyms: 3-[(6-Deoxy-a-L-mannopyranosyl)oxy]-7-b-D-glucopyranosyloxy-5-hydroxy-2-(4-methoxyphenyl)-4H-1-benzopyran-4-one. Grades: ≥ 98%. CAS No. 489-32-7. Molecular formula: C33H40O15. Mole weight: 676.66.
Icariside I is extracted from the herbs of Epimedium brevicornum Maxim. Synonyms: Icariin I. Grades: >98%. CAS No. 56725-99-6. Molecular formula: C27H30O11. Mole weight: 530.5.
Icariside I
Icariside I Inhibitor. Uses: Scientific use. Product Category: T3808. CAS No. 56725-99-6.
Icariside I
Icariside I. Group: Biochemicals. Grades: Plant Grade. CAS No. 56725-99-6. Pack Sizes: 10mg. Molecular Formula: C27H30O11, Molecular Weight: 530.52. US Biological Life Sciences.
Worldwide
Icaritin
Icaritin is unable to promote proliferation, migration and tube-like structure formation by human umbilical vein endothelial cells (HUVECs) in vitro. Icaritin potently inhibited proliferation of K562 cells (IC50 was 8 μM) and primary CML cells (IC50 was 13.4 μM for CML-CP and 18 μM for CML-BC), induced CML cells apoptosis and promoted the erythroid differentiation of K562 cells with time-dependent manner. Furthermore, Icaritin was able to suppress the growth of primary CD34+ leukemia cells (CML) and Imatinib-resistant cells, and to induce apoptosis. Icaritin strongly inhibited the growth of breast cancer MDA-MB-453 and MCF7 cells. At concentrations of 2-3 μM, icaritin induced cell cycle arrest at the G(2)/M phase accompanied by a down-regulation of the expression levels of the G(2)/M regulatory proteins such as cyclinB, cdc2 and cdc25C. Icaritin at concentrations of 4-5 μM, however, induced apoptotic cell death characterized by the accumulation of the annexin V- and propidium iodide-positive cells, cleavage of poly ADP-ribose polymerase (PARP) and down-regulation of the Bcl-2 expression. In mouse leukemia model, Icaritin could prolong lifespan of NOD-SCID nude mice inoculated with K562 cells as effective as Imatinib without suppression of bone marrow. Icaritin could up-regulate phospho-JNK or phospho-C-Jun and down-regulate phospho-ERK, phospho-P-38, Jak-2, phospho-Stat3 and phospho-Akt expression with dose- or time-dependent manner. Synonyms: Anhydroicaritin; 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one; 3-hydroxy-7-o-beta-glucose-8-prenyl-4''-methoxy Chrysin. Grades: >98%. CAS No. 118525-40-9. Molecular formula: C21H20O6. Mole weight: 368.38.
Icaritin. Group: Biochemicals. Alternative Names: 3,5,7-Trihydroxy-2-(4-methoxyphenyl)-8-(3-methyl-2-buten-1-yl)-4H-1-benzopyran-4-one. Grades: Highly Purified. CAS No. 118525-40-9. Pack Sizes: 100mg, 250mg, 500mg, 1g, 2g. Molecular Formula: C21H20O6. US Biological Life Sciences.
Worldwide
Icaritin
Icaritin - Product ID: NST-10-167. Category: Flavonoids. Purity: 98%. Test method: HPLC. CAS No. 118525-40-9. Pack Sizes: 0,05g, 0,1g, 0,25g, 0,5g. Appearance: White Powder. Molecular formula: C21H20O6. Mole weight: 368.38. Storage: +2 +8 °C.
Icaritin (Anhydroicaritin)
Icaritin (Anhydroicaritin). Group: Biochemicals. Grades: Plant Grade. CAS No. 118525-40-9. Pack Sizes: 20mg. Molecular Formula: C21H20O6, Molecular Weight: 368.38. US Biological Life Sciences.
Worldwide
Icaritin Liposome (PEGylated)
Icaritin is a natural flavonoid compound that exhibits anticancer effects on various tumors, including hematologic malignancies such as leukemia, lymphoma, and multiple myeloma. This product is a pre-formulated liposome encapsulating Icaritin. It is only for research purposes. Group: Drug-loaded liposome. Categories: Niosomes, ethosomes, and transfersomes.
i-Carradecaitoldecasulfate decasodium salt
i-Carradecaitoldecasulfate decasodium salt is a groundbreaking biomedical compound which can inhibit designated enzymes responsible for exacerbating cancer cell proliferation. It aids in studying lung, breast and prostate malignancies. Molecular formula: C60H84O72S10Na10. Mole weight: 2507.82.
i-Carrahexaitol hexasulfate hexasodium salt
i-Carrahexaitol hexasulfate hexasodium salt is a derivative derived from i-Carrahexaitol, offering unprecedented opportunities for studying a multitude of diseases and conditions such as drug-resistant cancers and inflammatory disorders. Molecular formula: C36H52O44S6Na6. Mole weight: 1519.11.
i-Carrahexaose hexasulfate hexasodium salt
i-Carrahexaose hexasulfate hexasodium salt, an innovative biomedical substance, stands as a formidable solution against an array of ailments. By virtue of its unrivaled chemical configuration, it exhibits an outstanding capacity to impede the replication of notorious infectious agents such as HIV, influenza, and herpes viruses. Moreover, this extraordinary therapeutic treasure finds application in tackling inflammatory disorders and combating cancer. Molecular formula: C36H50O43S6Na6. Mole weight: 1501.09.
i-Carraoctaitol octasulfate octasodium salt
i-Carraoctaitol octasulfate octasodium salt, an eminent biomedicine product, distinguishes itself as a paramount entity employed in the amelioration of diverse maladies. Exhibiting efficacy across ailments such as cancer, cardiovascular disorders, and inflammatory diseases, this multifaceted compound assumes the role of a commendable therapeutic intervention. Molecular formula: C48H68O58S8Na8. Mole weight: 2013.46.
i-Carratetraitol tetrasulfate tetrasodium salt
i-Carratetraitol tetrasulfate tetrasodium salt is an extraordinary pharmaceutical compound extensively employed in the biomedical sphere. This exceptional substance showcases unparalleled efficiency in studying enduring inflammatory ailments, such as arthritand asthma. Molecular formula: C24H36O30S4Na4. Mole weight: 1024.75.
i-Carratetraose tetrasulfate tetrasodium salt
i-Carratetraose tetrasulfate tetrasodium salt is a potent biomedical compound used in the treatment of various inflammatory conditions and autoimmune diseases. It exhibits excellent anti-inflammatory properties by effectively inhibiting the activation of pro-inflammatory cytokines. This product acts as a therapeutic agent to alleviate symptoms associated with conditions such as rheumatoid arthritis and Crohn's disease while promoting immune modulation. Molecular formula: C24H34O29S4Na4. Mole weight: 1006.73.
Icatibant
Icatibant(HOE-140) is a selective and specific antagonist of bradykinin B2 receptor with IC50 and Ki of 1.07 nM and 0.798 nM respectively. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-; H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-D-Tic-Oic-Arg-OH; D-Arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-L-arginine; HOE140; HOE 140; HOE-140. Grades: >98%. CAS No. 130308-48-4. Molecular formula: C59H89N19O13S. Mole weight: 1304.52.
Icatibant Acetate
Icatibant acetate is a selective antagonist of bradykinin B2 receptors. Icatibant is a medication approved for the treatment of acute attacks of hereditary angioedema (HAE) in adults with C1-esterase-inhibitor deficiency. Uses: Anti-inflammatory agents, non-steroidal. Synonyms: HOE 140 Acetate; HOE140 Acetate; HOE-140 Acetate; L-Arginine, D-arginyl-L-arginyl-L-prolyl-(4R)-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-(3R)-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-(2S,3aS,7aS)-octahydro-1H-indole-2-carbonyl-, acetate (1:x); H-D-Arg-Arg-Pro-Hyp-Gly-2Thi-Ser-D-Tic-Oic-Arg-OH.CH3CO2H; L-Arginine, D-arginyl-L-arginyl-L-prolyl-trans-4-hydroxy-L-prolylglycyl-3-(2-thienyl)-L-alanyl-L-seryl-D-1,2,3,4-tetrahydro-3-isoquinolinecarbonyl-L-(2α,3aβ,7aβ)-octahydro-1H-indole-2-carbonyl-, acetate (salt); Firazyr. Grades: ≥95%. CAS No. 138614-30-9. Molecular formula: C59H89N19O13S.xC2H4O2. Mole weight: 1304.52 (free base).
ICBA is a C60 derivative that can be synthesized from C60 and indene. It is an acceptor material with shallow lowest occupied molecular orbital(LUMO) which can be used to enhance the performance of polymeric solar cells(PSCs). Uses: Icba can be used with poly(3-hexylthiophene)(p3ht) as an active layer which can be used in the fabrication of organic solar cells(oscs).icba in combination with thiazolo-thiazolo can be used as a donor. it can be blended with pcbm for photovoltaic based application. Group: 3d printing materials carbon nano materials dye-sensitized solar cell (dssc) materials electronic materials organic field effect transistor (ofet) materials organic solar cell (opv) materials. Alternative Names: 1', 1'', 4', 4''-Tetrahydro-di[1, 4]methanonaphthaleno[1, 2:2', 3', 56, 60:2'', 3''][5, 6]fullerene-C60, C60 derivative, indene-C60 bisadduct. CAS No. 1207461-57-1. Pack Sizes: 250 mg in glass insert. Molecular formula: 952.99. Mole weight: C78H16. C1C2C3= CC= CC= C3C1C45C26C7= C8C9= C1C2= C3C% 10= C9C9= C% 11C% 12= C% 10C% 10= C% 13C% 14= C% 12C% 12= C% 15C% 16= C (C4= C4C% 17= C% 16C% 16= C% 18C% 19= C% 17C% 17= C% 20C% 21= C% 19C% 19= C% 22C% 23= C% 21C% 21= C (C1= C7C (= C% 21% 20) C6= C% 174) C2= C% 23C (= C3% 10) C% 221C% 13 (C2CC1C1= CC= CC= C21) C (= C% 18% 19) C% 14= C% 15% 16) C (= C% 12% 11) C5= C98. InChI=1S/C78H16/c1-2-6-12-11 (5-1) 15-9-16 (12) 76-69-53-37-23-25-41-29 (37) 30-38-24-26-42 (30) 58-57 (41) 73-65-49 (
I-CBP 112
I-CBP112 has been found to be a CBP/p300 bromodomain inhibitor and could reduce the leukemia-initiating potential of MLL-AF9(+) acute myeloid leukemia cells. Synonyms: I-CBP112; I-CBP-112; I-CBP 112. 1-[7-(3,4-Dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-2,3,4,5-tetrahydro-1,4-benzoxazepin-4-yl]propan-1-one. Grades: ≥98% by HPLC. CAS No. 1640282-31-0. Molecular formula: C27H36N2O5. Mole weight: 468.59.
I-CBP112 hydrochloride
I-CBP112 is a selective inhibitor of CBP and EP300 bromodomain (Kds = 0.142 and 0.625 μM, respectively). CBP and EP300 are histone acetyltransferase (HAT) enzymes that serve as transcriptional coactivators and have been found to be dysregulated in cancer and other diseases. Synonyms: 1-[7-(3,4-dimethoxyphenyl)-9-[[(3S)-1-methylpiperidin-3-yl]methoxy]-3,5-dihydro-2H-1,4-benzoxazepin-4-yl]propan-1-one hydrochloride. Grades: ≥90%. CAS No. 2147701-33-3. Molecular formula: C27H36N2O5·HCl. Mole weight: 505.1.
ICE Alginate
Natural thickener combination with sunflower wax and sodium alginate (alginic acid) to make stable all-round lotions. This ICE product is best combined with an emulsifier, such as polysorbate 20 for example, to get a smooth lotion. Alginate is a natural polysaccharide (sugar from brown algae) that has a large capacity of absorbing water. Hydrophile / lipophile balanced to ensure the highest viscosity. Uses: Creams, lotions, gel, hair care products. Group: Rheology modifiers. CAS No. 999999-99-4 / 9005-38-3 / 65381-09-1 / 73398-61-5. Appearance: Off-white powder. Catalog: CI-SC-0538.
ICE Blend
Instant-cold-emulsion powder made of emulsifiers & sodium polyacrylate. Can be added to water forming instant thick creams. No heating required, saves time. Heat sensitive ingredients such as actives are safe and can be added easily. Compatible with many oils. Uses: Creams, lotions, serums, baby products, makeup, hair products & sun care. Group: Surfactants/emulsifiers. CAS No. 57-11-4 / 68439-49-6 / 67762-27-0 / 600-07-7. Appearance: White powder, mild fatty odor. Catalog: CI-SC-0256.
ICEC-0942
ICEC-0942 is a small-molecule cyclin-dependent kinase 7 (CDK7) inhibitor developed for cancer therapy. Preclinical study in Acute Myeloid Leukaemia (AML) models shows that ICEC-0942 effectively inhibits the proliferation of several AML cell lines and patient derived AML cells in vitro (IC50 = 0.15-2.6 μM). Uses: Anticancer drug. Synonyms: CT7001; CT 7001; CT-7001; ICEC0942; ICEC0 942; ICEC0-942. CAS No. 1805833-75-3. Molecular formula: C22H30N6O. Mole weight: 394.52.
ICE Conditioner
Conditioning instant-cold-emulsion powder naturally derived from rapeseed (canola) oil, coconut oil & vegetable oils. Based on the primary lipids found on the hair surface. Hydrophile / lipophile balanced to ensure the highest viscosity & conditioning effect. Uses: Creams, lotions, serums, conditioners. Group: Sensory modifiers. CAS No. 36653-82-4 / 17301-53-0 / 61789-40-0 / 1338-39-2. Appearance: White powder, mild fatty odor. Catalog: CI-SC-0132.
ICE Hair Restore
Ready-to-mix deep hair conditioner consisting of two quaternary conditioners and an emulsifier. Uses: Hair rinses, hair conditioners, hair masks. Group: Cationic surfactants & conditioning agents. CAS No. 67762-27-0/17301-53-0/26161-33-1. Appearance: Off-white powder, typical odor. Catalog: CI-HC-0062.
Iceland Moss Extract
Extract obtained from Cetraria Islandica (Iceland Moss) plants. Contains 20% extract dissolved in water and glycerin. Has Soothing and good moisturizing properties. Uses: Creams and lotions, especially for dry and chaffed skin. Group: Skin actives. CAS No. 7732-18-5 / 56-81-5 / 84776-25-0 / 122-99-6. Appearance: Light to pale yellow liquid, characteristic odor. Catalog: CI-SC-0861.
ICE Olivate
Natural instant-cold-emulsion powder made of Glyceryl stearate (and) cetearyl alcohol (and) sodium olivate (and) inulin. Can be added to room temperature or warm/ hot water forming instant thick creams. (Slightly heated water will help with quicker dissolving). Blend on high for best results. Heat sensitive ingredients such as actives are safe and can be added easily. Can also be used as a viscosity builder/emulsifier in regular hot process emulsions. Uses: Creams, lotions, serums, makeup, hair products & sun care. Group: Rheology modifiers. CAS No. 31566-31-1 / 67762-27-0 / 61789-88-6 / 9005-80-5. Appearance: white to cream powder granular wax-like solid. Catalog: CI-SC-0532.
ICE Silicone
Instant-cold-emulsion powder that contains emulsifiers, thickeners and is enriched with a silicon blend for a nice soft, cushioning elegant after feel. Uses: Creams, lotions, serums, color cosmetics. Group: Sensory modifiers. CAS No. 36653-82-4 / 9003-04-7 / 9005-65-6 / 123-94-4 / 153668-87-2. Appearance: White powder, mild fatty odor. Catalog: CI-SC-0133.
ICE Sunflower
Instant-cold-emulsion powder made of sunflower wax & sodium polyacrylate. Can be added to water forming instant thick creams. No heating required, saves time. Heat sensitive ingredients such as actives are safe and can be added easily. Higher amounts need the addition of a liquid emulsifier. Can also be used as a visco-sity builder in regular hot process emulsions. Uses: Creams, lotions, serums, makeup, hair products & sun care. Group: Surfactants/emulsifiers. CAS No. 1286686-34-7/9003-04-7. Appearance: White powder, mild fatty odor. Catalog: CI-SC-0229.
ICG-001 is an antagonist of Wnt/β-catenin/TCF-mediated transcription and binds to cyclic AMP responsive element binding-binding protein (CBP)-mediated transcription with IC50 value of 3 μM. ICG-001 has been demonstrated to inhibit gastric cancer cell growth and reduce chemoresistance of cancer stem cell-like population. Synonyms: ICG 001; (6S,9aS)-N-benzyl-6-[(4-hydroxyphenyl)methyl]-8-(naphthalen-1-ylmethyl)-4,7-dioxo-3,6,9,9a-tetrahydro-2H-pyrazino[1,2-a]pyrimidine-1-carboxamide. Grades: >98%. CAS No. 780757-88-2. Molecular formula: C33H32N4O4. Mole weight: 548.63.
Ichthammol is an antibacterial, fungicidal, antiinflammatory agent. Group: Biochemicals. Grades: Highly Purified. CAS No. 8029-68-3. Pack Sizes: 100g, 250g. Molecular Formula: N/A, Molecular Weight: US Biological Life Sciences.
Worldwide
Ichthammol
Antimicrobial agent. Group: Non-ionic surfactants. Alternative Names: Ichthammonium. CAS No. 8029-68-3. IUPACName: hydroxyurea. Canonical SMILES: C(=O)(N)NO. Catalog: ACM8029683.
Ichthammol USP
Ichthammol USP.
CA, FL & NJ
ICI-118551 HCl
A highly selective antagonist for the β2 adrenergic receptors. Binds to the β2 subtype with at least 100 times greater affinity than β1 or β3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively). Synonyms: ICI-118551; ICI118551; ICI 118551; ICI-118,551; ICI118,551; ICI 118,551. Grades: 98%. CAS No. 72795-19-8. Molecular formula: C17H28ClNO2. Mole weight: 313.866.
ICI 118551 hydrochloride
ICI 118551 hydrochloride is a highly selective β2 adrenergic antagonist (Ki values are 1.2, 120 and 257 nM for β2, β1 and β3 receptors respectively), inhibited cAMP accumulation by 50% (IC50 = 1.5 microM and 1.7 microM, respectively). Uses: A highly selective β2 adrenergic receptor antagonist. Synonyms: ICI 118551 hydrochloride; ICI118551 hydrochloride; ICI-118551 hydrochloride; (±)-erythro-(S*,S*)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride;(2R,3S)-1-[(7-methyl-2,3-dihydro-1H-inden-4-yl)oxy]-3-(propan-2-ylamino)butan-2-ol;hydrochloride. Grades: ≥98%. CAS No. 72795-01-8. Molecular formula: C17H27NO2.HCl. Mole weight: 313.86.
A highly selective antagonist for the beta-2 adrenergic receptors. Binds to the beta-2 subtype with at least 100 times greater affinity than beta-1 or beta-3, the two other known subtypes of the beta adrenoceptor. (Ki values are 1.2, 120 and 257nM for beta-2, beta-1 and beta-3 receptors respectively). Group: Biochemicals. Grades: Highly Purified. CAS No. 72795-19-8. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
ICI141292
ICI141292, also known as Epanolol, is a adrenergic β-antagonist with a greater affinity for β1- than β2-adrenoceptors, which is used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches, and anxiety. Synonyms: N-[2-[[3-(2-cyanophenoxy)-2-hydroxypropyl]amino]ethyl]-2-(4-hydroxyphenyl)acetamide; epanolol; ICI 141,292; ICI 141292; ICI-141,292; N-(2-((3-(2-cyanophenoxy)-2-hydroxypropyl)amino)ethyl)-4-hydroxyphenylacetamide; Visacor. CAS No. 86880-51-5. Molecular formula: C20H23N3O4. Mole weight: 369.41.
ICI 154,129
ICI 154,129 is a selective δ opioid antagonist. It is a peptide analog that antagonized the effects of Leu-enkephalin. Uses: Narcotic antagonists. Synonyms: N,N-Di(2-propenyl)-L-Tyr-N-[2-[[(S)-2-[[(S)-1-carboxy-3-methylbutyl]amino]-2-oxo-1-benzylethyl]thio]ethyl]-Gly-NH2; M-154129. Grades: >98%. CAS No. 83420-94-4. Molecular formula: C34H46N4O6S. Mole weight: 638.83.
ICI 162,846
ICI 162,846 is a potent histamine H2 receptor antagonist. Synonyms: ICI 162,846; ICI162,846; ICI-162,846; N-[1-(4-Carboxamidobutyl)-1H-pyrazol-3-yl)]-N'-(2,2,2-trifluoroethyl)guanidine; 3-[[Imino[(2,2,2-trifluoroethyl)amino]methyl]amino]-1H-pyrazole-1-pentanamide. CAS No. 84545-30-2. Molecular formula: C11H17F3N6O. Mole weight: 306.29.
ICI 174,864
ICI 174,864 is a potent and highly selective δ opioid antagonist. It shows partial agonist in vitro activity at δ receptors at high concentrations. Synonyms: ICI 174,864; ICI174,864; ICI-174,864; N,N-Di-2-propen-1-yl-L-tyrosyl-2-methylalanyl-L-phenylalanyl-L-leucine; NIH 10893; N,N-diallyl-tyrosyl-alpha-aminoisobutyric acid-phenylalanyl-leucine; L-Leucine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-L-phenylalanyl)-; N,N-Diallyl-Tyr-aib-Phe-Leu. Grades: >98%. CAS No. 89352-67-0. Molecular formula: C38H53N5O7. Mole weight: 691.87.
ICI 185,282
ICI 185,282 is a potent thromboxane receptor antagonist. Synonyms: ICI-185282; ICI 185282; ICI185282; 5-(Z)-7-(4-o-Hydroxyphenyl-2-trifluoromethyl-1,3 dioxan-cis-5-yl)heptenoic acid. CAS No. 106393-80-0. Molecular formula: C18H21F3O5. Mole weight: 374.36.
ICI 192,605
ICI 192,605 is a potent thromboxane A2 receptor antagonist. It can reverse vasoconstriction induced by inhibition of NO production and inhibits platelet aggregation, which leads to an increase in TXA2 release. It also inhibits contractile responses to U 46619. Synonyms: ICI 192605 ; ICI192605; ICI-192605. (4Z)-rel-, 4(Z)-6-(2-o-chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl) hexenoic acid; 4-Hexenoic acid, 6-[(2R,4R,5S)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-; 4-(Z)-6-(2-o-Chlorophenyl-4-o-hydroxyphenyl-1,3-dioxan-cis-5-yl)hexenoic acid; (E)-6-[(2S,4S,5R)-2-(2-chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]hex-4-enoic acid; rel-(4Z)-6-[(2R,4R,5S)-2-(2-Chlorophenyl)-4-(2-hydroxyphenyl)-1,3-dioxan-5-yl]-4-hexenoic Acid. Grades: ≥98% by HPLC. CAS No. 117621-64-4. Molecular formula: C22H23ClO5. Mole weight: 402.87.
ICI-198615
ICI-198615 is a novel, potent and selective peptide leukotriene antagonist. It may be useful for the the treatment of allergic diseases. Uses: Ici-198615 may be useful for the the treatment of allergic diseases. Synonyms: [1-[[2-Methoxy-4-[[ (phenylsulfonyl) amino]carbonyl]phenyl]methyl]-1H-indazol-6-yl]carbamic acid cyclopentyl ester;Cyclopentyl N-[1-[[4-(benzenesulfonylcarbamoyl)-2-methoxyphenyl]methyl]indazol-6-yl]carbamate;ICI 198615; ICI-198615; ICI198615; ICI-198,615; ZM 198615; ZM-198615. Grades: >98 %. CAS No. 104448-53-5. Molecular formula: C28H28N4O6S. Mole weight: 548.61.
ICI 199,441 hydrochloride
ICI 199,441 hydrochloride is the hydrochloride salt of ICI 199,441, which is a selective and highly potent κ agonist. It is 146-fold more active than U-50488 in vitro. It has a broad range of effects on the immune system ranging from inflammatory response modulation to opioid and chemokine receptor expression. It has analgesic properties. Synonyms: ICI 199,441 hydrochloride; ICI199,441 hydrochloride; ICI-199,441 hydrochloride; 3,4-Dichloro-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]-benzeneacetamide Monohydrochloride; (S)-3,4-Dichloro-N-methyl-N-[1-phenyl-2-(1-pyrrolidinyl)ethyl]-benzeneacetamide Monohydrochloride; 2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamide hydrochloride. Grades: ≥99% by HPLC. CAS No. 115199-84-3. Molecular formula: C21H25Cl3N2O. Mole weight: 427.80.
ICI 204,448 hydrochloride
ICI 204,448 hydrochloride is the hydrochloride salt of ICI 204,448, which is a peripherally acting κ opioid receptor agonist. It does not cross the blood-brain barrier. Synonyms: ICI 204,448 hydrochloride; ICI204,448 hydrochloride; ICI-204,448 hydrochloride; (±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride; (RS)-[3-[1-[[(3,4-Dichlorophenyl)acetyl]methylamino]-2-(1-pyrrolidinyl)ethyl]phenoxy]acetic acid hydrochloride. Grades: ≥98% by HPLC. CAS No. 121264-04-8. Molecular formula: C23H27Cl3N2O4. Mole weight: 501.84.
ICI 211965
ICI 211965 is a selective 5-lipoxygenase inhibitor and it may be useful in regulating production of those interleukins involved in joint cartilage destruction. Synonyms: ICI 211965; ICI-211965; ICI211965; 1-(3-(Naphth-2-ylmethoxy)phenyl)-1-(thiazol-2-yl)propyl methyl ether. Grades: 98%. CAS No. 129424-08-4. Molecular formula: C24H23NO2S. Mole weight: 389.52.
ICI 216140 is a GRP/bombesin receptor 2 antagonist (IC50 = 2 nM in vitro). Grades: ≥95%. CAS No. 124001-41-8. Molecular formula: C45H65N13O8. Mole weight: 916.1.
ICI 63197
ICI 63197. Group: Biochemicals. Grades: Purified. CAS No. 27277-00-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ICI 63197
ICI 63197 is a specific and potent cAMP phosphodiesterase IV (PDE 4) inhibitor. Its IC50 value is 35 nM for inhibition of [3H]-rolipram binding to rat brain. It is potent in anatagonizing reserpine-induced hypothermia. It has an antidepressant effect following systemic administration in vivo. Synonyms: ICI 63197; ICI63197; ICI-63197; 2-Amino-6-methyl-4-propyl-[1,2,4]triazolo[1,5-a]pyrimidin-5(4H)-one; 2-Amino-4,5-dihydro-6-methyl-4-propyl-s-triazolo[1,5-a]pyrimidin-5-one. Grades: ≥99% by HPLC. CAS No. 27277-00-5. Molecular formula: C9H13N5O. Mole weight: 207.23.
ICI 89406
ICI 89406 is a selective β-adrenergic antagonist. It is a low efficacy partial agonist and does not affect resting cardiac parameters. Synonyms: ICI 89406; ICI89406; ICI-89406; N-[2-[3-(2-Cyanophenoxy)-2-hydroxypropylamino]ethyl]-N'-phenylurea. Grades: ≥99% by HPLC. CAS No. 53671-71-9. Molecular formula: C19H22N4O3. Mole weight: 354.41.
Icilin
Icilin. Group: Biochemicals. Grades: Purified. CAS No. 36945-98-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.