A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Icomethasone 21-Mesylate is a derivative of Icomethasone, used in the preparation of Mometasone. Group: Biochemicals. Alternative Names: (11 β , 16α ) -9-Chloro-11, 17-dihydroxy-16-methyl-21-[ (methylsulfonyl) oxy]pregna-1, 4-diene-3, 20-dione. Grades: Highly Purified. CAS No. 352315-75-4. Pack Sizes: 10mg. Molecular Formula: C23H31ClO7S, Molecular Weight: 487.01. US Biological Life Sciences.
Worldwide
Icomethasone 21-Mesylate
Icomethasone 21-Mesylate. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: Pregna-1,4-diene-3,20-dione, 9-chloro-11,17-dihydroxy-16-methyl-21-[(methylsulfonyl)oxy]-, (11β,16α)-, Icomethasone 21-mesylate, 9-Chloro-11β,17-dihydroxy-16α-methyl-3,20-dioxopregna-1,4-dien-21-yl Methanesulfonate, Mometasone Furoate Imp. N (EP), (11β,16α)-9-Chloro-11,17-dihydroxy-16-methyl-21-[(methylsulfonyl)oxy]pregna-1,4-diene-3,20-dione. CAS No. 352315-75-4. Pack Sizes: 10MG. IUPAC Name: [2-[(8S,9R,10S,11S,13S,14S,16R,17R)-9-chloro-11,17-dihydroxy-10,13,16-trimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] methanesulfonate. Molecular Formula: C23H31ClO7S. Mole Weight: 487.01. Catalog: APS352315754. SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC (=O)C=C[C@]4 (C)[C@@]3 (Cl)[C@@H] (O)C[C@]2 (C)[C@@]1 (O)C (=O)COS (=O) (=O)C. Format: Neat. Shipping: Room Temperature.
Icomidocholic acid
Icomidocholic acid (Aramchol) is a lipid molecule synthesized from cholic acid and arachidic acid. Icomidocholic acid is an orally active SCD1 inhibitor and cholesterol solubilizer with antifibrotic effects. Icomidocholic acid can reduce liver fat content, dissolve cholesterol crystals and prevent gallstone formation. Icomidocholic acid can be used in the study of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis (NASH) [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Aramchol; C20-FABAC. CAS No. 246529-22-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-19796.
Icopezil maleate
The maleate salt form of Icopezil, a benzoxazol derivative, has been found to be an acetylcholinesterase inhibitor and was once studied for the treatment of Alzheimer's disease. It has already been discontinued by Pfizer. Synonyms: CP 118954-11; CP-118,954-11. UNII-1P15W0SPEN; Icopezil maleate [USAN]; Icopezil maleate (USAN); 145815-98-1; CHEMBL329012; CP 118954-11. Grades: 98%. CAS No. 145815-98-1. Molecular formula: C27H29N3O6. Mole weight: 491.54.
Icosabutate
Icosabutate, an orally active ω-3 polyunsaturated fatty acid, is an aeicosapentaenoic acid (EPA) derivative. Icosabutate overcomes the drawbacks of unmodified EPA for liver targeting and improves insulin sensitivity, hepatic inflammation and fibrosis [1]. Icosabutate is well tolerated, and efficacious in lowering non-high-density lipoprotein cholesterol (non-HDL-C) levels in persistent hypertriglyceridemia [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1253909-57-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-121212.
Icosanamide, a derivative of fatty acid, displays promise as a therapeutic agent for diverse inflammatory ailments. With its impressive anti-inflammatory attributes, the compound has garnered attention for handling autoimmune diseases and treating conditions such as rheumatoid arthritis. Its efficacy is well-documented in several clinical studies. Synonyms: Eicosanamide; Arachamide. CAS No. 51360-63-5. Molecular formula: C20H41NO. Mole weight: 311.554.
icosanoyl-CoA 5-desaturase
The enzyme, characterized from the plant Limnanthes douglasii (meadowfoam), is involved in the biosynthesis of (5Z)-icos-5-enoate, an unusual monounsaturated fatty acid that makes up to 60% of the total fatty acids in Limnanthes sp. seed oil. The enzyme only acts on saturated fatty acids. Group: Enzymes. Synonyms: acyl-CoA Δ5-desaturase (ambiguous). Enzyme Commission Number: EC 1.14.19.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-0972; icosanoyl-CoA 5-desaturase; EC 1.14.19.10; acyl-CoA Δ5-desaturase (ambiguous). Cat No: EXWM-0972.
Icotinib Hydrochloride (BPI-2009H), or Icotinib, is a highly selective, first generation epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI). Synonyms: BPI-2009H. Grades: >98%. CAS No. 610798-31-7. Molecular formula: C22H21N3O4. Mole weight: 391.42.
Icotinib
Icotinib (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009. CAS No. 610798-31-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164A.
Icotinib-D4
Icotinib-D4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1567366-82-8. Molecular Formula: C22H17D4N3O4. Mole Weight: 395.45. Catalog: APB1567366828.
Icotinib Hydrochloride
Icotinib Hydrochloride (BPI-2009) is a potent and specific EGFR inhibitor with an IC 50 of 5 nM; also inhibits mutant EGFR L858R , EGFR L858R/T790M , EGFR T790M and EGFR L861Q. Icotinib (Hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups. Uses: Scientific research. Group: Signaling pathways. Alternative Names: BPI-2009H. CAS No. 1204313-51-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-15164.
Icotinib Impurity 1
Icotinib Impurity 1. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1058651-74-3. Molecular Formula: C22H21N3O5. Mole Weight: 407.43. Catalog: APB1058651743.
Icotinib Impurity 10
Icotinib Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2376901-56-1. Molecular Formula: C20H21N3O5. Mole Weight: 383.4. Catalog: APB2376901561.
Icotinib Impurity 11
Icotinib Impurity 11. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2305154-39-4. Molecular Formula: C17H12N4O2. Mole Weight: 304.31. Catalog: APB2305154394.
Icotinib Impurity 12
Icotinib Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 610798-26-0. Molecular Formula: C20H20ClN3O4. Mole Weight: 401.85. Catalog: APB610798260.
Icotinib Impurity 13
Icotinib Impurity 13. Uses: For analytical and research use. Group: Impurity standards. CAS No. 610798-18-0. Molecular Formula: C20H20BrN3O4. Mole Weight: 446.3. Catalog: APB610798180.
Icotinib Impurity 14
Icotinib Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1887066-23-0. Molecular Formula: C22H25N3O5. Mole Weight: 411.46. Catalog: APB1887066230.
Icotinib Impurity 15
Icotinib Impurity 15. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1887066-21-8. Molecular Formula: C20H21N3O4. Mole Weight: 367.41. Catalog: APB1887066218.
Icotinib Impurity 16
Icotinib Impurity 16. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1708935-17-4. Molecular Formula: C19H15N3O3. Mole Weight: 333.35. Catalog: APB1708935174.
Icotinib Impurity 17
Icotinib Impurity 17. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2376901-55-0. Molecular Formula: C20H21N3O5. Mole Weight: 383.4. Catalog: APB2376901550.
Icotinib Impurity 18
Icotinib Impurity 18. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1318600-04-2. Molecular Formula: C22H23N3O6. Mole Weight: 425.44. Catalog: APB1318600042.
Icotinib Impurity 19
Icotinib Impurity 19. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1318600-10-0. Molecular Formula: C22H25N3O6. Mole Weight: 427.46. Catalog: APB1318600100.
Icotinib Impurity 2
Icotinib Impurity 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1643673-64-6. Molecular Formula: C22H20ClN3O4. Mole Weight: 425.87. Catalog: APB1643673646.
Icotinib Impurity 20
Icotinib Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1318600-06-4. Molecular Formula: C22H23N3O6. Mole Weight: 425.44. Catalog: APB1318600064.
Icotinib Impurity 21
Icotinib Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1708935-20-9. Molecular Formula: C21H19N3O4. Mole Weight: 377.4. Catalog: APB1708935209.
Icotinib Impurity 3
Icotinib Impurity 3. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1643673-51-1. Molecular Formula: C22H20FN3O4. Mole Weight: 409.42. Catalog: APB1643673511.
Icotinib Impurity 4
Icotinib Impurity 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1058651-82-3. Molecular Formula: C28H29N3O11. Mole Weight: 583.55. Catalog: APB1058651823.
Icotinib Impurity 5
Icotinib Impurity 5. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2249867-59-0. Molecular Formula: C18H13N3O2. Mole Weight: 303.32. Catalog: APB2249867590.
Icotinib Impurity 6
Icotinib Impurity 6. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1869913-77-8. Molecular Formula: C20H21N3O5. Mole Weight: 383.4. Catalog: APB1869913778.
Icotinib Impurity 7
Icotinib Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2249867-60-3. Molecular Formula: C19H15N3O2. Mole Weight: 317.35. Catalog: APB2249867603.
Icotinib Impurity 8
Icotinib Impurity 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 153437-34-4. Molecular Formula: C17H15N3O2. Mole Weight: 293.33. Catalog: APB153437344.
Icotinib Impurity 9
Icotinib Impurity 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 412930-46-2. Molecular Formula: C18H17N3O2. Mole Weight: 307.35. Catalog: APB412930462.
ICP-MS Internal Standard: Ge @ 100 ug/mL in 2% HNO3
ICP-MS Internal Standard: Ge @ 100 ug/mL in 2% HNO3. Uses: For analytical and research use. Group: Aqueous inorganic; aqueous inorganic. Alternative Names: Ge. CAS No. 7440-56-4. Pack Sizes: 100ML. IUPAC Name: germanium. Molecular Formula: Ge. Mole Weight: 72.64. Catalog: APS7440564E. SMILES: [Ge]. Format: Single Solution. Shipping: Room Temperature.
ICRF-193
ICRF-193 is an TopoII inhibitor. (S,S)- and (R,R)-isomers ICRF-193 make up an racemic mixture, ICRF-196 (HY-118590A). ICRF-196 can be used for the research of cancer [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 21416-88-6. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-118590.
iCRT 14
iCRT 14. Group: Biochemicals. Grades: Purified. CAS No. 677331-12-3. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
iCRT 14
iCRT 14 is a novel potent inhibitor of β-catenin-responsive transcription (CRT) that inhibits Wnt signaling. It is thought to directly influence the interaction between β-catenin and TCF4. It also induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Synonyms: iCRT14; iCRT-14; iCRT 14; Wnt inhibitor; CHEMBL3589010; STK155594; 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione. Grades: >98%. CAS No. 677331-12-3. Molecular formula: C21H17N3O2S. Mole weight: 375.44.
iCRT-14
A potent inhibitor of β-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity). Studies suggest that it may directly influence the interaction between β-catenin and TCF4. It induces marked G0/G1 cell cycle arrest in HCT-116 and HT29 cell lines. Group: Biochemicals. Alternative Names: 5-[[2,5-Dimethyl-1-(3-pyridinyl)-1H-pyrrol-3-yl]methylene]-3-phenyl-2,4-thiazolidinedione; iCRT 14; iCRT14. Grades: Highly Purified. CAS No. 677331-12-3. Pack Sizes: 10mg. US Biological Life Sciences.
Worldwide
iCRT5
iCRT5 is a Potent and cell-permeable β-catenin-responsive transcription (CRT) inhibitor (IC50 value of 18 nM for Wnt responsive STF16 luciferase). iCRT5 disrupts the interaction between β-catenin and TCF4, possibly by direct binding to β-catenin. Synonyms: iCRT5; iCRT-5; iCRT 5; 4-[5-(3,4-Dimethoxy-benzylidene)-4-oxo-2-thioxo-thiazolidin-3-yl]-butyric acid; 4-[(5Z)-5-[(3,4-dimethoxyphenyl)methylidene]-4-oxo-2-sulfanylidene-1,3-thiazolidin-3-yl]butanoic acid; EN300-00774; AC1Q49FJ. Grades: 99%. CAS No. 18623-44-4. Molecular formula: C16H17NO5S2. Mole weight: 367.44.
ID-11014A
ID-11014A is a potent and selective agonist of GPR40 (free fatty acid receptor 1) that can increase insulin secretion and reduce glucose levels. Studies shows that it has a lower liver toxicity than TAK-785 and an improved glucose tolerance. Uses: The potential treatment of diabetes. Synonyms: ID 11014A.
ID 8
ID 8. Group: Biochemicals. Grades: Purified. CAS No. 147591-46-6. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
Worldwide
ID-8
ID-8 is an inhibitor of dual-specificity tyrosine phosphorylation-regulated kinase (DYRK). ID-8 sustains embryonic stem cell (ESC) self-renewal and pluripotency. ID-8 enhances Wnt-mediated hESC survival and proliferation via inhibition of DYRKs [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 147591-46-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15838.
ID-8
ID-8 is a DYRK inhibitor, and sustains embryonic stem cell self-renewal in long-term culture. Synonyms: ID-8; ID 8; ID8. Grades: >98%. CAS No. 147591-46-6. Molecular formula: C16H14N2O4. Mole weight: 298.29.
ID-8
ID-8. Group: Biochemicals. Alternative Names: ID 8, 1-(4-Methoxyphenyl)-2-methyl-3-nitro-1H-indol-6-ol, AC1LGAMV, HY-15838. Grades: Highly Purified. CAS No. 147591-46-6. Pack Sizes: 25mg. Molecular Formula: C16 H14 N2O4, Molecular Weight: 298.3. US Biological Life Sciences.
Worldwide
Idalopirdine hydrochloride
Idalopirdine hydrochloride (Lu AE58054 hydrochloride) is a potent, selective 5-HT6 receptor antagonist with a K i value of 0.83 nM. Idalopirdine hydrochloride may be used in studies of Alzheimer's disease and schizophrenia, among other related disorders [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: Lu AE58054 hydrochloride. CAS No. 467458-02-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-14338A.
Idarubicin
Idarubicin. Uses: For analytical and research use. Group: Impurity standards. CAS No. 58957-92-9. Molecular Formula: C26H27NO9. Mole Weight: 497.5. Catalog: APB58957929.
Idarubicin-d3. Readily exchangeable deuterium labels in protic solvents
Labelled Idarubicin, an orally active anthracycline; analog of Daunorubicin. Antineoplastic. Group: Biochemicals. Grades: Highly Purified. Pack Sizes: 250ug, 1mg. Molecular Formula: C26H24D3NO9. US Biological Life Sciences.
Worldwide
Idarubicin hydrochloride
Idarubicin hydrochloride is an anthracycline antileukemic agent. It inhibits the topoisomerase II interfering with the replication of DNA and RNA transcription. Idarubicin hydrochloride inhibits the growth of bacteria and yeasts. Uses: Scientific research. Group: Signaling pathways. Alternative Names: 4-Demethoxydaunorubicin hydrochloride. CAS No. 57852-57-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-17381.
Idarubicin hydrochloride
10mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C26H27NO9. CAS No. 58957-92-9. Prepack ID 63240268-10mg. Molecular Weight 497.49. See USA prepack pricing.
Idarubicin hydrochloride
25mg Pack Size. Group: Bioactive Small Molecules, Research Organics & Inorganics. Formula: C26H27NO9. CAS No. 58957-92-9. Prepack ID 63240268-25mg. Molecular Weight 497.49. See USA prepack pricing.
Idarubicin Hydrochloride
Idarubicin HCl is a hydrochloride salt form of Idarubicin which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor for MCF-7 cells with IC50 of 3.3 ng/mL. Uses: Antibiotics, antineoplastic. Synonyms: (7S,9S)-9-Acetyl-7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-5,12-naphthacenedione Hydrochloride; 4-DMD HCl; 4-Demethoxydaunorubicin Hydrochloride; Idamycin; NSC 256439; Zavedos; (1S,3S)-3-Acetyl-3,5,12-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydro-1-tetracenyl 3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranoside hydrochloride (1:1). Grades: >98%. CAS No. 57852-57-0. Molecular formula: C26H27NO9.HCl. Mole weight: 533.95.
Idarubicin Hydrochloride
Orally active anthracycline; analog of Daunorubicin. Antineoplastic. Group: Biochemicals. Alternative Names: (7S,9S)-Hydrochloride; Idamycin; NSC 256439; Zavedos. Grades: Highly Purified. CAS No. 57852-57-0. Pack Sizes: 5mg. US Biological Life Sciences.
Worldwide
Idarubicin impurities 2
Idarubicin impurities 2. Uses: For analytical and research use. Group: Impurity standards. CAS No. 84499-12-7. Molecular Formula: C20H12O5. Mole Weight: 332.31. Catalog: APB84499127.
Idarubicin impurities 4
Idarubicin impurities 4. Uses: For analytical and research use. Group: Impurity standards. CAS No. 58957-93-0. Molecular Formula: C26H27NO9. Mole Weight: 497.5. Catalog: APB58957930.
Idarubicin impurities 7
Idarubicin impurities 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 69804-36-0. Molecular Formula: C27H27NO9. Mole Weight: 509.51. Catalog: APB69804360.
Idarubicin impurities 8
Idarubicin impurities 8. Uses: For analytical and research use. Group: Impurity standards. CAS No. 58199-96-5. Molecular Formula: C26H28ClNO11. Mole Weight: 565.96. Catalog: APB58199965.
Idarubicin impurities 9
Idarubicin impurities 9. Uses: For analytical and research use. Group: Impurity standards. CAS No. 749168-24-9. Molecular Formula: C6H13NO3. Mole Weight: 147.17. Catalog: APB749168249.
Idarubicinol
Idarubicinol is the alcohol analog of Idarubicin, which is an anthracycline antibiotic and a DNA topoisomerase II (topo II) inhibitor. It is also an analog of Daunorubicin. Synonyms: 5,12-Naphthacenedione, 7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-[(1S)-1-hydroxyethyl]-, (7S,9S)-; (7S,9S)-7-[(3-Amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-[(1S)-1-hydroxyethyl]-5,12-naphthacenedione; 5,12-Naphthacenedione, 7-[(3-amino-2,3,6-trideoxy-α-L-lyxo-hexopyranosyl)oxy]-7,8,9,10-tetrahydro-6,9,11-trihydroxy-9-(1-hydroxyethyl)-, [7S-[7α,9α,9(R*)]]-; 13-Dihydroidarubicin; 4-Demethoxydaunorubicinol; Antibiotic FCE 22723. Grades: > 95%. CAS No. 86189-66-4. Molecular formula: C26H29NO9. Mole weight: 499.52.
Idarubicinone. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione. CAS No. 60660-75-5. Molecular Formula: C20H16O7. Mole Weight: 368.34. Catalog: APB60660755.
Idarubicinone
Idarubicinone is a derivative of Daunorubicin, which is an anthracycline antibiotic used in the treatment of acute myeloid and lymphocytic leukemia, with adverse reactions such as cardiotoxicity and bone marrow suppression. Synonyms: 4-demethoxy daunomycinone; (7S,9S)-9-acetyl-6,7,9,11-tetrahydroxy-7,8,9,10-tetrahydrotetracene-5,12-dione; 4-Demethoxydaunomycinone; Idarubicin aglycone; (+)-4-Demethoxydaunomycinone; 5,12-Naphthacenedione, 9-acetyl-7,8,9,10-tetrahydro-6,7,9,11-tetrahydroxy-, (7S-cis)-; (+)-Idarubicinone; (8S,10S)-7,8,9,10-Tetrahydro-6,8,10,11-tetrahydroxy-8-acetyl-5,12-naphthacenedione. Grades: ≥95%. CAS No. 60660-75-5. Molecular formula: C20H16O7. Mole weight: 368.34.
Idasanutlin
Idasanutlin; also known as RG7388 and RO5503781, is a highly potent and selective MDM2 antagonist with potential anticancer activity. RG7388 binds to MDM2 blocking the interaction between the MDM2 protein and the transcriptional activation domain of the tumor suppressor protein p53. By preventing the MDM2-p53 interaction, p53 is not enzymatically degraded and the transcriptional activity of p53 is restored. This may lead to p53-mediated induction of tumor cell apoptosis. MDM2, a zinc finger nuclear phosphoprotein and negative regulator of the p53 pathway, is often overexpressed in cancer cells and has been implicated in cancer cell proliferation and survival. Uses: For research used only. Synonyms: RG7388; RG 7388; RG-7388; RO5503781; RO-5503781; RO 5503781. Grades: >98%. CAS No. 1229705-06-9. Molecular formula: C31H29Cl2F2N3O4. Mole weight: 616.487.
Idasanutlin
Idasanutlin (RG7388) is a potent and selective MDM2 antagonist, inhibiting p53-MDM2 binding, with an IC 50 of 6 nM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RG7388. CAS No. 1229705-06-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15676.
Idazoxan hydrochloride
Idazoxan hydrochloride (RX 781094 hydrochloride) is an α 2 -adrenoceptor antagonist and is also a imidazoline receptors (IRs) antagonist competitively antagonized the centrally induced hypotensive effect of imidazoline-like agents (IMs). Idazoxan hydrochloride also improves motor symptoms in Parkinsons disease, L-DOPA-induced dyskinesias, and experimental Parkinsonism [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: RX 781094 hydrochloride. CAS No. 79944-56-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg. Product ID: HY-14561A.
Idazoxan hydrochloride
Idazoxan hydrochloride is the hydrochloride salt of idazoxan, which is an I2 imidazoline receptor agonist, I1 imidazoline receptor antagonist, as well as an alpha2-adrenoceptor antagonist. It is selective for α2- over α1-receptors. It is useful for the treatment of parkinsonian and schizophrenia. Synonyms: 1H-Imidazole, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-, hydrochloride (1:1); 1H-Imidazole, 2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-, monohydrochloride; (±)-Idazoxan monohydrochloride; 2-(2,3-Dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole hydrochloride; RX 781094; RX 781094A. Grades: ≥98%. CAS No. 79944-56-2. Molecular formula: C11H13ClN2O2. Mole weight: 240.69.
Idazoxan hydrochloride
Idazoxan hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 79944-56-2. Pack Sizes: 10mg, 50mg. US Biological Life Sciences.
A non-selective antagonist for alpha-2-adrenoceptors (pKi = 8.01, 7.43, and 7.7 for alpha-2A, alpha-2B, and alpha-2C receptors respectively) and imidazoline receptors. (pKi = 5.90, 7.22 for I1 and I2, receptors respectively). Widely used in studying functions of the nervous systems, such as learning and memory, decision making, reward, attention, addiction, depression, and schizophrenia related to the adrenergic receptors, and blood pressure regulation, pain modulation, and neuroprotection related to the imidazoline receptors. Group: Biochemicals. Grades: Highly Purified. CAS No. 79944-56-2. Pack Sizes: 50mg. US Biological Life Sciences.
Cell-permeable. Directs differentiation of embryonic stem cells (ESCs) into the endodermal lineage (EC??=125nm). Nodal/Smad signaling is activated indicating IDE-1 functions via TGF-b-signaling pathway. Group: Biochemicals. Grades: Highly Purified. CAS No. 1160927-48-9. Pack Sizes: 1mg, 5mg . US Biological Life Sciences.