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| Product | Description | |
|---|---|---|
| IgG2, Kappa from human myeloma plasma | purified immunoglobulin, >95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. |  |
| IgG2, Lambda from human myeloma plasma | purified immunoglobulin, >95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| IgG3, Kappa from human myeloma plasma | purified immunoglobulin, >90% (microfluidic capillary gel electrophoresis). Group: Fluorescence/luminescence spectroscopy. | |
| IgG3, Kappa from murine myeloma | clone DX, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| IgG3, Lambda from human myeloma plasma | purified immunoglobulin, >90% (microfluidic capillary gel electrophoresis). Group: Fluorescence/luminescence spectroscopy. | |
| IgG3, Lambda from murine myeloma | clone Y5606, purified immunoglobulin, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| IgG4, Lambda from human myeloma plasma | purified immunoglobulin, >95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy. | |
| IgG?FITC from human serum | ~20 mg/mL, buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| IgG from bovine serum | reagent grade, ?95% (SDS-PAGE), essentially salt-free, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| IgG from goat serum | reagent grade, ?95% (SDS-PAGE), essentially salt-free, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| IgG from rabbit serum | reagent grade, ?95% (SDS-PAGE), essentially salt-free, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| IgG from sheep serum | reagent grade, ?95% (SDS-PAGE), essentially salt-free, lyophilized powder. Group: Fluorescence/luminescence spectroscopy. | |
| IgM from bovine serum | reagent grade, ?95% (SDS-PAGE or HPLC), buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| IgM from human serum | reagent grade, ~95% (HPLC), buffered aqueous solution. Group: Fluorescence/luminescence spectroscopy. | |
| iGOT1-01 | iGOT1-01 is a potent aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1; GOT1) inhibitor. iGOT1-01 has IC50s of 85 ?M and 11.3 ?M in MDH coupled GOT1 enzymatic assay and GOT1/GLOX/HRP assay, respectively. iGOT1-01 has anti-cancer activity[1][2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 882256-55-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-124825. |  |
| iGOT1-01 | iGOT1-01 is an inhibitor of aspartate aminotransferase 1 (glutamate oxaloacetate transaminase 1, GOT1). Uses: Designed for use in research and industrial production. Additional or Alternative Names: iGOT101; iGOT1 01; iGOT1-01; iGOT 101; iGOT-101. Product Category: Inhibitors. Appearance: Solid powder. CAS No. 882256-55-5. Molecular formula: C19H20N4O. Mole weight: 320.4. Purity: >98%. IUPACName: 4-(1H-Indol-4-yl)-N-phenylpiperazine-1-carboxamide. Canonical SMILES: O=C(N1CCN(C2=CC=CC3=C2C=CN3)CC1)NC4=CC=CC=C4. Product ID: ACM882256555. Alfa Chemistry — ISO 9001:2015 Certified. |  |
| Iguratimod | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| Iguratimod | Iguratimod is a selective inhibitor of cyclo-oxygenase-2 (COX-2), and inhibits the production of interleukin-1 (IL-1), IL-6, IL-8 and tumour necrosis factor. Uses: Anti-inflammation agent. Synonyms: T 614; T-614; T614; N-(7-(Methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)formamide; Careram; Kolbet; UNII-4IHY34Y2NV. Grades: 0.98. CAS No. 123663-49-0. Molecular formula: C17H14N2O6S. Mole weight: 374.367. |  |
| Iguratimod | Iguratimod. Group: Biochemicals. Alternative Names: N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-1-benzopyran-7-yl]-methanesulfonamide; 3-Formylamino-7-methylsulfonylamino-6-phenoxy-4H-1-benzopyran-4-one; Careram; Kolbet; N-[3-(Formylamino)-4-oxo-6-phenoxy-4H-chromen-7-yl]methanesulfonamide; T 614; T 614 (antiinflammatory). Grades: Highly Purified. CAS No. 123663-49-0. Pack Sizes: 10mg. Molecular Formula: C17H14N2O6S, Molecular Weight: 374.37. US Biological Life Sciences. |  Worldwide |
| Iguratimod | Iguratimod is an antirheumatic agent, acts as an inhibitor of COX-2 , with an IC 50 of 20 μM (7.7 μg/mL), but shows no effect on COX-1. Iguratimod also inhibits macrophage migration inhibitory factor ( MIF ) with an IC 50 of 6.81 μM. Uses: Scientific research. Group: Signaling pathways. Alternative Names: T614. CAS No. 123663-49-0. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg. Product ID: HY-17009. | |
| Iguratimod Impurity 20 | Iguratimod Impurity 20. Uses: For analytical and research use. Group: Impurity standards. CAS No. 123663-50-3. Molecular formula: C18H16N2O6S. Mole weight: 388.39. Catalog: APB123663503. | |
| Iguratimod Impurity 28 | Iguratimod Impurity 28. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(2-chloro-5-methoxyphenyl)methanesulfonamide. CAS No. 1340086-28-3. Molecular formula: C8H10ClNO3S. Mole weight: 235.69. Catalog: APB1340086283. | |
| Iguratimod Impurity 30 | Iguratimod Impurity 30. Uses: For analytical and research use. Group: Impurity standards. CAS No. 123663-48-9. Molecular formula: C16H14N2O5S. Mole weight: 346.36. Catalog: APB123663489. | |
| Iguratimod Impurity 33 | Iguratimod Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 150831-14-4. Molecular formula: C15H16N2O5S. Mole weight: 336.36. Catalog: APB150831144. | |
| Iguratimod Impurity 35 | Iguratimod Impurity 35. Uses: For analytical and research use. Group: Impurity standards. CAS No. 10298-80-3. Molecular formula: C7H6ClNO3. Mole weight: 187.58. Catalog: APB10298803. | |
| Iguratimod Impurity 4 | Iguratimod Impurity 4. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(5-methoxy-2-phenoxyphenyl)methanesulfonamide. CAS No. 123664-84-6. Molecular formula: C14H15NO4S. Mole weight: 293.34. Catalog: APB123664846. | |
| Iguratimod Impurity E | Iguratimod Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)acetamide. CAS No. 123662-92-0. Molecular formula: C18H16N2O6S. Mole weight: 388.39. Catalog: APB123662920. | |
| iHCK-37 | iHCK-37 (ASN05260065) is a potent and specific Hck inhibitor with a Ki value of 0.22 ?M. iHCK-37 blocks HIV-1 viral replication with an EC50 value of 12.9 ?M. iHCK-37 is used for chronic myeloid leukemia (CML) research[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: ASN05260065. CAS No. 516478-09-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-139147. | |
| IHMT-PI3Kδ-372 S-isomer | An S isomer of IHMT-PI3Kδ-372, a potent and selective PI3Kδ inhibitor used for the treatment of chronic obstructive pulmonary disease. Synonyms: 2-[(1S)-1-[4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro-4(3H)-quinazolinone. CAS No. 2429889-61-0. Molecular formula: C26H23F2N7O2. Mole weight: 503.5. | |
| IHR 1 | IHR 1 is a potent and cell-membrane-impermeable Smo antagonist with IC50 value of 7.6 nM. It blocks hedgehog induced movement of Smo and blocks Smo accumulation into the primary cilium. It selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Synonyms: IHR-1; IHR 1; IHR1; N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]. Grades: ≥99% by HPLC. CAS No. 548779-60-8. Molecular formula: C20H12Cl4N2O2. Mole weight: 454.13. | |
| IHR-1 | IHR-1 is a cell membrane impermeable Smo antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 548779-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110240. | |
| IHR-1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IHR-Cy3 | IHR-Cy3 is a potent fluorescent Smo antagonist with IC50 value of 100 nM. Synonyms: (2-[3-[1- (6-[[7-[[4-Chloro-3-[[4- (2, 5-dichlorobenzamido) phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1, 3-dihydro-3, 3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3, 3-dimethyl-5-sulfo-3H-indolium, inner salt. Grades: ≥95% by HPLC. Molecular formula: C58H63Cl3N6O10S2. Mole weight: 1174.64. | |
| II-B08 | This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 μM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future. Uses: Anticancer and antileukemia treatment. Synonyms: II-B08; II-B 08; II-B-08. CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. Grades: 98%. CAS No. 1143579-78-5. Molecular formula: C33H27N5O4. Mole weight: 557.61. | |
| III-31-C | ?98% (HPLC), solid. Group: Fluorescence/luminescence spectroscopy. | |
| i-Inositol | i-Inositol (myo-Inositol) is a compound of sugar alcohols. i-Inositol is involved in a series of biological processes such as insulin signal transduction and cytoskeletal transduction. i-Inositol mainly exists in glial cells and plays an osmotic role[1][2][3]. Uses: Scientific research. Group: Natural products. Alternative Names: myo-Inositol; meso-Inositol. CAS No. 87-89-8. Pack Sizes: 10 mM * 1 mL; 500 mg; 5 g. Product ID: HY-B1411. | |
| IITZ-01 | IITZ-01 is a potent autophagy inhibitor that is accumulated in lysosomes. IITZ-01 exhibited anticancer effects in MDA-MB-231 breast cancer xenograft model. Synonyms: EX-A2763; HY-112897; AK00792538; 4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine. CAS No. 1807988-47-1. Molecular formula: C26H23FN8O. Mole weight: 482.51. | |
| IK-175 | IK-175 is a selective and orally active aryl hydrocarbon receptor (AHR) inhibitor. IK-175 effectively blocks AHR from translocating from the cytoplasm to the nucleus. IK-175 is highly selective for AHR over other receptors, transporters, and kinases[1]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: AHR antagonist 5 free base. CAS No. 2247950-42-9. Pack Sizes: 1 mg; 5 mg; 10 mg; 25 mg. Product ID: HY-141609. | |
| IK-930 | IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy. CAS No. 2563892-44-2. Molecular formula: C19H19F3N4O2S. Mole weight: 424.44. | |
| IK-930 | IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC 50 value of <0.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153585. | |
| IκB kinase | The enzyme phosphorylates IκB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-κB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. Group: Enzymes. Synonyms: CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Enzyme Commission Number: EC 2.7.11.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3129; IκB kinase; EC 2.7.11.10; CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Cat No: EXWM-3129. |  |
| Ikarisoside F | Ikarisoside F, a flavonol glycoside from Vancouveria hexandra, could bind to AdoHcy hydrolase. Synonyms: Ikarisoside F. Grades: >98%. CAS No. 113558-14-8. Molecular formula: C31H36O14. Mole weight: 632.61. | |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. | |
| Ikarugamycin | An unusual pentacyclic tetramic acid produced by streptomyces phaeochromogenes; potent activity against the protozoan, trichomonas vaginalis; demonstrates selective gram positive antibacterial activity, and anti-ulcer activity possibly via inhibition of H. Pylori; inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis; a useful agent for studying the process of endocytosis. Synonyms: 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. Grades: >99% by HPLC. CAS No. 36531-78-9. Molecular formula: C29H38N2O4. Mole weight: 478.62. | |
| Ikarugamycin | Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful. Group: Biochemicals. Grades: Highly Purified. CAS No. 36531-78-9. Pack Sizes: 500ug. US Biological Life Sciences. | Worldwide |
| Ikarugamycin | ?98% (HPLC), from Streptomyces sp. Group: Fluorescence/luminescence spectroscopy. | |
| IkB alpha Control Cell Extracts | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| iKIX1 | iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[ (3, 4-dichlorophenyl) carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2. | |
| iKIX1 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IKK 16 | IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM). Synonyms: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; IKK-16; IKK 16; IKK16; IKK-16. Grades: >98%. CAS No. 873225-46-8. Molecular formula: C28H29N5OS. Mole weight: 483.63. | |
| IKK 16 | IKK 16 is a selective I?B kinase (IKK) inhibitor for IKK2, IKK complex and IKK1 with IC50s of 40 nM, 70 nM and 200 nM, respectively. IKK16 also inhibits leucine-rich repeat kinase-2 (LRRK2) with an IC50 of 50 nM. Uses: Scientific research. Group: Signaling pathways. CAS No. 873225-46-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687. | |
| IKK 16 | IKK 16. Group: Biochemicals. Grades: Purified. CAS No. 1186195-62-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| IKK-16 dihydrochloride | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IKK-16 HCl | Cas No. 1186195-62-9. | |
| IKK 16 hydrochloride | IKK 16 hydrochloride is an orally active IKK inhibitor. IKK 16 hydrochloride shows IC50s of 40 nM, 70 nM, 200 nM, and 50 nM for IKK2, IKK complex, IKK1, and LRRK 2, respectively. IKK 16 hydrochloride is also a pan-PKD inhibitor, inhibiting PKD1, PKD2, and PKD3 with IC50s of 153.9, 115, and 99.7 nM, respectively. IKK 16 hydrochloride is also an ABCB1 inhibitor, interfering with the binding of ABCB1 to its substrates. IKK 16 hydrochloride protects against LPS (HY-D1056)-induced multiple organ dysfunction by reducing the acute inflammatory response induced by endotoxin exposure. IKK 16 hydrochloride can restore renal function and alleviate fibrosis in acute kidney injury. IKK 16 hydrochloride attenuates cardiac dysfunction associated with polymicrobial sepsis in mice with type 2 diabetes mellitus (T2DM) by inhibiting the NF-?B pathway[1][2][3][4][5][6][7]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1186195-62-9. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13687A. | |
| IKK2 Inhibitor VI | IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grades: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3. | |
| IKK-2 inhibitor VIII | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grades: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9. | |
| IKK-3 Inhibitor | IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-&beta. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grades: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53. | |
| IKK ? , active, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| IKKβ-IN-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC 50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4815-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028127. | |
| IKKε-IN-1 | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grades: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52. | |
| IKK epsilon/TBK1 Inhibitor II, MRT67307 (TANK Binding Kinase 1/IKKinducible Inhibitor II, N- (3- (5-Cyclopropyl -2- (3- (morpholino methyl ) phenylamino) pyrimidin-4-ylamino) propyl ) cyclobutane carboxamide) | A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflammÂ… Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| IKK-?, GST tagged human | recombinant, expressed in baculovirus infected Sf9 cells, ?70% (SDS-PAGE), buffered aqueous glycerol solution. Group: Fluorescence/luminescence spectroscopy. | |
| IL-10 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-11 human | recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 from mouse | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 from rat | recombinant, expressed in baculovirus infected Sf9 cells, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| IL-12 human | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12p40 human | recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
| IL-12p80 human | recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy. | |
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