A directory of where to buy chemicals in the USA, including: distributors, industrial manufacturers, bulk supplies and wholesalers of raw ingredients & finished goods.
Iguratimod Impurity E. Uses: For analytical and research use. Group: Impurity standards. Alternative Names: N-(7-(methylsulfonamido)-4-oxo-6-phenoxy-4H-chromen-3-yl)acetamide. CAS No. 123662-92-0. Molecular formula: C18H16N2O6S. Mole weight: 388.39. Catalog: APB123662920.
IHMT-PI3Kδ-372 S-isomer
An S isomer of IHMT-PI3Kδ-372, a potent and selective PI3Kδ inhibitor used for the treatment of chronic obstructive pulmonary disease. Synonyms: 2-[(1S)-1-[4-Amino-3-(3-fluoro-4-methoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]propyl]-3-cyclopropyl-5-fluoro-4(3H)-quinazolinone. CAS No. 2429889-61-0. Molecular formula: C26H23F2N7O2. Mole weight: 503.5.
IHR 1
IHR 1 is a potent and cell-membrane-impermeable Smo antagonist with IC50 value of 7.6 nM. It blocks hedgehog induced movement of Smo and blocks Smo accumulation into the primary cilium. It selectively inhibits Hedgehog signaling over Wnt and Notch signaling pathways. Synonyms: IHR-1; IHR 1; IHR1; N,N'-1,4-Phenylenebis[2,5-dichlorobenzamide]. Grades: ≥99% by HPLC. CAS No. 548779-60-8. Molecular formula: C20H12Cl4N2O2. Mole weight: 454.13.
IHR-1 is a cell membrane impermeable Smo antagonist [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 548779-60-8. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-110240.
IHR-Cy3
IHR-Cy3 is a potent fluorescent Smo antagonist with IC50 value of 100 nM. Synonyms: (2-[3-[1- (6-[[7-[[4-Chloro-3-[[4- (2, 5-dichlorobenzamido) phenyl]carbamoyl]phenyl]amino]-7-oxoheptylamino]-6-oxohexyl]-1, 3-dihydro-3, 3-dimethyl-5-sulfo-2H-indol-2-ylidene]-1-propen-1-yl]-1-ethyl-3, 3-dimethyl-5-sulfo-3H-indolium, inner salt. Grades: ≥95% by HPLC. Molecular formula: C58H63Cl3N6O10S2. Mole weight: 1174.64.
II-B08
This active molecular is a cell-permeable SHP2 inhibitor which blocks growth factor stimulated hematopoietic progenitor proliferation and ERK1/2 activation. IC50 is 5.5 μM. II-B08 may be therapeutically useful for anticancer and antileukemia treatment in the future. Uses: Anticancer and antileukemia treatment. Synonyms: II-B08; II-B 08; II-B-08. CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. 3-(1-(3-(Biphenyl-4-ylamino)-3-oxopropyl)-1H-1,2,3-triazol-4-yl)-6-hydroxy-1-methyl-2-phenyl-1H-indole-5-carboxylic acid,CD45 Inhibitor V, FAP1 Inhibitor, LMWPTP Inhibitor, Lyp Inhibitor III, PTP1B Inhibitor IX, SHP1 Inhibitor IX. Grades: 98%. CAS No. 1143579-78-5. Molecular formula: C33H27N5O4. Mole weight: 557.61.
IITZ-01 is a potent autophagy inhibitor that is accumulated in lysosomes. IITZ-01 exhibited anticancer effects in MDA-MB-231 breast cancer xenograft model. Synonyms: EX-A2763; HY-112897; AK00792538; 4-N-[4-(1H-benzimidazol-2-yl)phenyl]-2-N-(4-fluorophenyl)-6-morpholin-4-yl-1,3,5-triazine-2,4-diamine. CAS No. 1807988-47-1. Molecular formula: C26H23FN8O. Mole weight: 482.51.
IK-930
IK930, a novel TEAD inhibitor, sensitizes KRAS and EGFR mutant tumors to oncogene targeted therapy. CAS No. 2563892-44-2. Molecular formula: C19H19F3N4O2S. Mole weight: 424.44.
IK-930
IK-930 (compound I-32) is a potent and orally active TEAD inhibitor with an EC 50 value of <0.1 μM [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 2563892-44-2. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-153585.
IκB kinase
The enzyme phosphorylates IκB proteins at specific serine residues, which marks them for destruction via the ubiquitination pathway. Subsequent degradation of the IkB complex (IKK) activates NF-κB, a translation factor that plays an important role in inflammation, immunity, cell proliferation and apoptosis. If the serine residues are replaced by threonine residues, the activity of the enzyme is decreased considerably. Group: Enzymes. Synonyms: CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Enzyme Commission Number: EC 2.7.11.10. Storage: Store it at +4 ?C for short term. For long term storage, store it at -20 ?C?-80 ?C. Form: Liquid or lyophilized powder. EXWM-3129; IκB kinase; EC 2.7.11.10; CHUK; IKBKA; IKBKB; IKK; IKK-1; IKK-2; inhibitor of NFκB kinase; inhibitor of NF-κB kinase; STK12; TANK-binding kinase 1; TBK1. Cat No: EXWM-3129.
Ikarisoside F
Ikarisoside F, a flavonol glycoside from Vancouveria hexandra, could bind to AdoHcy hydrolase. Synonyms: Ikarisoside F. Grades: >98%. CAS No. 113558-14-8. Molecular formula: C31H36O14. Mole weight: 632.61.
Ikarugamycin
Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764.
Ikarugamycin
?98% (HPLC), from Streptomyces sp. Group: Fluorescence/luminescence spectroscopy.
Ikarugamycin
An unusual pentacyclic tetramic acid produced by streptomyces phaeochromogenes; potent activity against the protozoan, trichomonas vaginalis; demonstrates selective gram positive antibacterial activity, and anti-ulcer activity possibly via inhibition of H. Pylori; inhibits the uptake of oxidized low-density lipoprotein in mouse macrophages, blocks PMA and nef-mediated cell surface CD4 down-regulation, and inhibits clathrin-coated pit-mediated endocytosis; a useful agent for studying the process of endocytosis. Synonyms: 14,17-Metheno-17H-as-indaceno[3,2-k][1,6]diazacycloheptadecine-9,16,18(1H)-trione. Grades: >99% by HPLC. CAS No. 36531-78-9. Molecular formula: C29H38N2O4. Mole weight: 478.62.
Ikarugamycin
Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful. Group: Biochemicals. Grades: Highly Purified. CAS No. 36531-78-9. Pack Sizes: 500ug. US Biological Life Sciences.
Worldwide
IkB alpha Control Cell Extracts
The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences.
Worldwide
iKIX1
iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[ (3, 4-dichlorophenyl) carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2.
IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grades: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3.
IKK-2 inhibitor VIII
IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grades: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9.
IKK-3 Inhibitor
IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-&beta. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grades: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53.
IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC 50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4815-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028127.
IKKε-IN-1
IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grades: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52.
A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflammÂ… Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences.
recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-12p40 human
recombinant, expressed in CHO cells, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-12p80 human
recombinant, expressed in (BTI-Tn-5B1-4) High-5 Insect Cells, ?95% (SDS-PAGE), ?95% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-13 from rat
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-13 Long Form from rat
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-13 Variant human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-15 from mouse
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-15 from rat
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-15 human
Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-16 (121aa) human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-16 from mouse
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-16 human
Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-17A from rat
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-17B human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-17D human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-17E from rat
recombinant, expressed in E. coli, ?95% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
IL-17E human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-17E murine
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-17F from mouse
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-17F from rat
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-17F human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-17 human
Animal-component free, recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-17-IN-2
IL-17-IN-2 (Example 51) is a potent inhibitor of IL-17 , with the IC 50 of < 0.4 μM in HTRF and NHK assay [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3058278-46-6. Pack Sizes: 1 mg. Product ID: HY-168582.
IL-19 from mouse
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-19 human
recombinant, expressed in E. coli, ?99% (SDS-PAGE), ?99% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-1RA murine
recombinant, expressed in E. coli, ?98% (SDS-PAGE). Group: Fluorescence/luminescence spectroscopy.
IL-1R Antagonist
IL-1R antagonist is an interleukin-1 receptor homology and a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88), modulating the interaction of MyD88 and IL-1 receptor type I (IL-1RI). In mice with deep partial-thickness scald wound, IL-1R antagonist decreases the expression of inflammation related factors IL-1β and TNF-α and fibrosis related factors TGF-β1, MMP-1, CTGF, and type ? collagen, promoting wound healing and ruducing fibrosis degree. Synonyms: Hydrocinnamoyl-L-valyl Pyrrolidine; N-[(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide. Grades: ≥98%. CAS No. 566914-00-9. Molecular formula: C18H26N2O2. Mole weight: 302.4.
IL-1R Antagonist - CAS 566914-00-9
The IL-1R Antagonist, also referenced under CAS 566914-00-9, controls the biological activity of IL-1R. Group: Fluorescence/luminescence spectroscopy.
Recombinant human IL - 2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Synonyms: Iloprost R-isomer; 74843-13-3; 16(R)-Iloprost; 16-(R)-Iloprost; UNII-AHG2128QW6; AHG2128QW6; (5E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid; (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; Pentanoic acid, 5-((3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, (5E)-; (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]hexahydropentalen-2(1h)-Ylidene]pentanoic Acid; IL2; SCHEMBL21509107; AKOS040755122; PD021248; Q27273925; 5-((3AS,4R,5R,6aS,E)-5-hydroxy-4-((3S,4R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid. Molecular formula: C22H32O4. Mole weight: 360.5.
IL-20 from mouse
recombinant, expressed in E. coli, ?95% (SDS-PAGE), ?95% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-20 human
recombinant, expressed in E. coli, ?97% (SDS-PAGE), ?97% (HPLC). Group: Fluorescence/luminescence spectroscopy.
IL-22 from mouse
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.
IL-22 human
recombinant, expressed in E. coli, ?98% (SDS-PAGE), ?98% (HPLC), suitable for cell culture. Group: Fluorescence/luminescence spectroscopy.