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| Product | Description | |
|---|---|---|
| Ikarugamycin | Ikarugamycin is an unsual pentacyclic tetramic acid produced by Streptomyces phaeochromogenes with potent activity against the protozoan, Trichomonas vaginalis, reported in 1972. Ikarugamycin also demonstrated selective Gram positive antibacterial activity and more recently has been shown to exhibit anti-ulcer activity possibly by inhibition of Helicobacter. Investigation of the pharmacology of ikarugamycin has demonstrated a variety of actions including the inhibition of the uptake of oxidized low-density lipoprotein in mouse macrophages, blockade of PMA and Nef-mediated cell surface CD4 down-regulation and inhibition of clathrin-coated pit-mediated endocytosis. Importantly, ikarugamycin is emerging as a useful. Group: Biochemicals. Grades: Highly Purified. CAS No. 36531-78-9. Pack Sizes: 500ug. US Biological Life Sciences. |  Worldwide |
| Ikarugamycin | Ikarugamycin is an antibiotic and a inhibitor of clathrin-mediated endocytosis (CME) [1]. Uses: Scientific research. Group: Natural products. CAS No. 36531-78-9. Pack Sizes: 500 μg; 1 mg. Product ID: HY-119764. |  |
| IkB alpha Control Cell Extracts | The NF-kB/Rel transcription factors are present in the cytosol in an inactive state, complexed with the inhibitory IkB proteins (1-3). Activation occurs via phosphorylation of IkB-a at Ser32 and Ser36, resulting in the release and nuclear translocation of active NF-kB (3-7). IkB-a phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals, including inflammatory cytokines, growth factors and chemokines. Phosphorylation of IkB-a at Ser32 and Ser36 has been shown to stimulate conjugation with ubiquitin followed by proteasome-mediated degradation of IkB, resulting in the release of active NF-kB. Kinases that phosphorylate IkB at these activating sites have been identified (8). Because phosphorylation of IkB-a at Ser32 is essential for release of active NF-kB, phosphorylation at this site is an excellent marker of NF-kB activation (1-3). Nonphosphorylated IkB-a Control Cell Extracts: Total cell extracts from HeLa cells prepared without treatment serve as a negative control. Group: Biologicals. Grades: Lysate. Pack Sizes: 200ul. US Biological Life Sciences. | Worldwide |
| iKIX1 | iKIX1 is an inhibitor of Pdr1-dependent gene activation. It re-sensitizes drug-resistant C. glabrata to azole antifungals in vitro and in amnimal models. Synonyms: 2-Cyano-N-{[ (3, 4-dichlorophenyl) carbamothioyl]amino}acetamide. CAS No. 656222-54-7. Molecular formula: C10H8Cl2N4OS. Mole weight: 303.2. |  |
| IKK 16 | IKK16 is a selective IκB kinase (IKK) inhibitor for IKK-2( IC50=40 nM), IKK complex( IC50=70 nM) and IKK-1(IC50=2000 nM). Synonyms: (4-((4-(benzo[b]thiophen-2-yl)pyrimidin-2-yl)amino)phenyl)(4-(pyrrolidin-1-yl)piperidin-1-yl)methanone; IKK-16; IKK 16; IKK16; IKK-16. Grades: >98%. CAS No. 873225-46-8. Molecular formula: C28H29N5OS. Mole weight: 483.63. | |
| IKK 16 | IKK 16. Group: Biochemicals. Grades: Purified. CAS No. 1186195-62-9. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| IKK-16 HCl | Cas No. 1186195-62-9. | |
| IKK2 Inhibitor VI | IKK2 Inhibitor VI is a cell-permeable and reversible inhibitor of NF-κB kinase 2 (IKK2/IKKβ), phosphorylating inhibitors of NF-κB (IκBs) to initiate signaling. Synonyms: 5-Phenyl-2-ureidothiophene-3-carboxylic acid amide; 5-Phenyl-2-ureidothiophene-3-carboxamide. Grades: ≥95%. CAS No. 354811-10-2. Molecular formula: C12H11N3O2S. Mole weight: 261.3. | |
| IKK-2 inhibitor VIII | IKK-2 inhibitor VIII is a potent and selective IKK-2 inhibitor. Synonyms: IKK-beta inhibitor; IKK beta inhibitor; IKK 2 inhibitor VIII. Grades: >98%. CAS No. 406209-26-5. Molecular formula: C21H25ClN4O2. Mole weight: 400.9. | |
| IKK-3 Inhibitor | IKK-3 Inhibitor is a potent, selective, inhibitor of IKK-epsilon kinase and is inactive at IKK-α and IKK-&beta. Synonyms: CAY10576; CAY 10576; CAY-10576; IKK-3 Inhibitor IX; 2-Thiophenecarbonitrile, 5-(5,6-dimethoxy-1H-benzimidazol-1-yl)-3-[[2-(methylsulfonyl)phenyl]methoxy]-. Grades: >98%. CAS No. 862812-98-4. Molecular formula: C22H19N3O5S2. Mole weight: 469.53. | |
| IKKβ-IN-4 | IKKβ-IN-4 (compound 14) is an IkappaB kinase-β ( IKKβ ) inhibitor with IC 50 value of 1.9 μM. IKKβ is a key enzyme in the NF-κB signaling pathway and is involved in the development of many diseases [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 4815-35-4. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-W028127. | |
| IKKε-IN-1 | IKKε-IN-1 is a potent IKKε inhibitor; inhibit the in-situ &Lota;KΚ ε-mediated phosphorylation of IRF3 with an IC50 value of less than about 100 nM. Synonyms: MDK10496; MDK10496; MDK10496; IKKε-IN-1. Grades: >98%. CAS No. 1292310-49-6. Molecular formula: C26H27N5O3. Mole weight: 457.52. | |
| IKK epsilon/TBK1 Inhibitor II, MRT67307 (TANK Binding Kinase 1/IKKinducible Inhibitor II, N- (3- (5-Cyclopropyl -2- (3- (morpholino methyl ) phenylamino) pyrimidin-4-ylamino) propyl ) cyclobutane carboxamide) | A cell-permeable BX795 analog that acts as a potent, ATP-competitive, and reversible dual kinase inhibitor of TBK1/IKK epsilon (IC50 = 19 and 160nM, respectively) with excellent selectivity over IKKalpha and IKKbeta (IC50 > 10uM). Interacts with the TBK1 kinase dimer interface and stabilizes the inactive DFG-out conformation. Also blocks the activity of MARK (microtubule- associated protein (MAP)-microtubule affinity regulating kinase) 1, 2, 3, and 4 (IC50 = 27, 52, 36, and 41nM, respectively), SIK2 (IC50 = 67nM) and Aurora B, JAK2, and MLK1,3 (> than 90% inhibition at 1uM) in a 108-kinase panel. Increases TNF-alpha-stimulated NF-kB-dependent gene transcription in wild-type macrophages and enhances CREB-dependent gene transcription by promoting dephosphorylation of CREB-regulated transcription coactivator (CRTC3). Shown to aid TLR-stimulated production of anti-Inflammatory cytokines in macrophages while suppressing the secretion of pro-inflammatory cytokines. In response to pro-inflamm Group: Biochemicals. Grades: Highly Purified. CAS No. 495-85-2. Pack Sizes: 5mg. Molecular Formula: C??H??N?O?. US Biological Life Sciences. | Worldwide |
| IL-17-IN-2 | IL-17-IN-2 (Example 51) is a potent inhibitor of IL-17 , with the IC 50 of < 0.4 μM in HTRF and NHK assay [1]. Uses: Scientific research. Group: Signaling pathways. CAS No. 3058278-46-6. Pack Sizes: 1 mg. Product ID: HY-168582. | |
| IL-1R Antagonist | IL-1R antagonist is an interleukin-1 receptor homology and a peptide mimic of the myeloid differentiation primary response gene 88 (MyD88), modulating the interaction of MyD88 and IL-1 receptor type I (IL-1RI). In mice with deep partial-thickness scald wound, IL-1R antagonist decreases the expression of inflammation related factors IL-1β and TNF-α and fibrosis related factors TGF-β1, MMP-1, CTGF, and type ? collagen, promoting wound healing and ruducing fibrosis degree. Synonyms: Hydrocinnamoyl-L-valyl Pyrrolidine; N-[(2S)-3-methyl-1-oxo-1-pyrrolidin-1-ylbutan-2-yl]-3-phenylpropanamide. Grades: ≥98%. CAS No. 566914-00-9. Molecular formula: C18H26N2O2. Mole weight: 302.4. | |
| IL2 | Recombinant human IL - 2; Interleukin-2 is a secreted cytokine, also called IL-2. Aldesleukin (IL-2 made in the laboratory) is being used as a biological response modifier to boost the immune system in cancer therapy. Synonyms: Iloprost R-isomer; 74843-13-3; 16(R)-Iloprost; 16-(R)-Iloprost; UNII-AHG2128QW6; AHG2128QW6; (5E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid; (5E)-5-[(3aS,4R,5R,6aS)-5-hydroxy-4-[(E,3S,4R)-3-hydroxy-4-methyloct-1-en-6-ynyl]-3,3a,4,5,6,6a-hexahydro-1H-pentalen-2-ylidene]pentanoic acid; Pentanoic acid, 5-((3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-((1E,3S,4R)-3-hydroxy-4-methyl-1-octen-6-ynyl)-2(1H)-pentalenylidene)-, (5E)-; (5e)-5-[(3as,4r,5r,6as)-5-Hydroxy-4-[(1e,3s,4r)-3-Hydroxy-4-Methyloct-1-En-6-Yn-1-Yl]hexahydropentalen-2(1h)-Ylidene]pentanoic Acid; IL2; SCHEMBL21509107; AKOS040755122; PD021248; Q27273925; 5-((3AS,4R,5R,6aS,E)-5-hydroxy-4-((3S,4R,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid. Molecular formula: C22H32O4. Mole weight: 360.5. | |
| Il-6(88-121)(human) | Il-6(88-121)(human). Uses: Designed for use in research and industrial production. Additional or Alternative Names: H-ILE-ILE-THR-GLY-LEU-LEU-GLU-PHE-GLU-VAL-TYR-LEU-GLU-TYR-LEU-GLN-ASN-ARG-PHE-GLU-SER-SER-GLU-GLU-GLN-ALA-ARG-ALA-VAL-GLN-MET-SER-THR-LYS-OH;IL-6 (88-121) (HUMAN);INTERLEUKIN-6 (88-121) (HUMAN);interleukin-6 fragment 88-121;IL-6 (88-121);Interleukin-6. Product Category: Heterocyclic Organic Compound. CAS No. 145990-81-4. Molecular formula: C179H281N45O58S. Product ID: ACM145990814. Alfa Chemistry ISO 9001:2015 Certified. |  |
| IL-7, IL-12, IL-21 | | |
| Ilamycin A | Ilamycin A is produced by the strain of Str. islandicus A-165-Z1. It is resistant to mycobacteria, including human mycobacterium tuberculosis, and also to streptomycin resistant bacteria. Grades: >97%. CAS No. 11006-41-0. Molecular formula: C54H75N9O12. Mole weight: 1042.22. | |
| Ilaprazole | Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H+/K+-ATPase in a dose-dependent manner with an IC50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor. Uses: Designed for use in research and industrial production. Additional or Alternative Names: Ilaprazole;2-[[(4-Methoxy-3-methyl-2-pyridinyl)methyl]sulfinyl]-6-(1H-pyrrol-1-yl)-1H-benzimidazole. Product Category: Inhibitors. Appearance: Solid. CAS No. 172152-36-2. Molecular formula: C19H18N4O2S. Mole weight: 366.44. Purity: 0.9926. Canonical SMILES: O=S(C1=NC2=CC=C(N3C=CC=C3)C=C2N1)CC4=NC=CC(OC)=C4C. Product ID: ACM172152362. Alfa Chemistry ISO 9001:2015 Certified. | |
| Ilaprazole | Ilaprazole (IY-81149) is an orally active proton pump inhibitor. Ilaprazole irreversibly inhibits H + /K + -ATPase in a dose-dependent manner with an IC 50 of pump inhibitory activity of 6 μM in rabbit parietal cell preparation. Ilaprazole is used for the research of gastric ulcers. Ilaprazole is also a potent TOPK (T-lymphokine-activated killer cell-originated protein kinase) inhibitor [1] [2]. Uses: Scientific research. Group: Signaling pathways. Alternative Names: IY-81149. CAS No. 172152-36-2. Pack Sizes: 2 mg; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-101664. | |
| Ilaprazole | Ilaprazole is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Group: Biochemicals. Grades: Highly Purified. CAS No. 172152-36-2. Pack Sizes: 10mg, 100mg. Molecular Formula: C19H18N4O2S, Molecular Weight: 366.44. US Biological Life Sciences. | Worldwide |
| Ilaprazole-d3 | Ilaprazole-d3 is labelled Ilaprazole (I266400) which is a proton pump inhibitor (PPI) used in the treatment of dyspepsia, peptic ulcer disease (PUD), gastroesophageal reflux disease (GORD/GERD) and duodenal ulcer. Group: Biochemicals. Grades: Highly Purified. CAS No. 10370969-17-3. Pack Sizes: 1mg. Molecular Formula: C19H15D3N4O2S, Molecular Weight: 369.46. US Biological Life Sciences. | Worldwide |
| Ilaprazole Impurity 1 | Grades: > 95%. Molecular formula: C19H18N4OS. Mole weight: 350.45. | |
| Ilaprazole Impurity 10 | Grades: > 95%. Molecular formula: C19H18N4OS. Mole weight: 350.45. | |
| Ilaprazole Impurity 10 | Ilaprazole Impurity 10. Uses: For analytical and research use. Group: Impurity standards. CAS No. 172152-35-1. Molecular Formula: C19H18N4OS. Mole Weight: 350.44. Catalog: APB172152351. |  |
| Ilaprazole Impurity 11 | Grades: > 95%. Molecular formula: C19H18N4O4S. Mole weight: 398.44. | |
| Ilaprazole Impurity 12 | Grades: > 95%. Molecular formula: C19H17ClN4O2S. Mole weight: 400.89. | |
| Ilaprazole Impurity 12 | Ilaprazole Impurity 12. Uses: For analytical and research use. Group: Impurity standards. CAS No. 228351-50-8. Molecular Formula: C19H19N4O+. Mole Weight: 319.39. Catalog: APB228351508. | |
| Ilaprazole Impurity 13 | Grades: > 95%. Molecular formula: C19H17ClN4O2S. Mole weight: 400.89. | |
| Ilaprazole Impurity 14 | Grades: > 95%. Molecular formula: C20H20N4OS. Mole weight: 364.47. | |
| Ilaprazole Impurity 14 | Ilaprazole Impurity 14. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1018229-53-2. Molecular Formula: C11H9N3O. Mole Weight: 199.21. Catalog: APB1018229532. | |
| Ilaprazole Impurity 15 | Grades: > 95%. Molecular formula: C16H20N2O4. Mole weight: 304.35. | |
| Ilaprazole Impurity 16 | Grades: > 95%. Molecular formula: C15H14N4O4S. Mole weight: 346.37. | |
| Ilaprazole Impurity 17 | Grades: > 95%. Molecular formula: C11H9N3O2S. Mole weight: 247.28. | |
| Ilaprazole Impurity 18 | Grades: > 95%. Molecular formula: C9H9N3OS. Mole weight: 207.26. | |
| Ilaprazole Impurity 19 | Grades: > 95%. Molecular formula: C9H9N3O3S. Mole weight: 239.25. | |
| Ilaprazole Impurity 2 | Grades: > 95%. Molecular formula: C27H27N5O3S. Mole weight: 501.61. | |
| Ilaprazole Impurity 20 | Grades: > 95%. Molecular formula: C8H9Cl2NO. Mole weight: 206.07. | |
| Ilaprazole Impurity 21 | Impurity of Ilaprazole. Synonyms: 2-Chloromethyl-3-methyl-4-nitro-pyridine. Grades: > 95%. Molecular formula: C7H7ClN2O2. Mole weight: 186.60. | |
| Ilaprazole Impurity 21 | Ilaprazole Impurity 21. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2285346-38-3. Molecular Formula: C19H16N4O3. Mole Weight: 348.36. Catalog: APB2285346383. | |
| Ilaprazole Impurity 22 | Ilaprazole Impurity 22. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2285346-39-4. Molecular Formula: C18H16N4O. Mole Weight: 304.35. Catalog: APB2285346394. | |
| Ilaprazole Impurity 22 | Impurity of Ilaprazole. Synonyms: 2-(3-Methyl-pyridin-2-ylmethanesulfinyl)-5-pyrrol-1-yl-1H-benzoimidazole. Grades: > 95%. Molecular formula: C18H16N4OS. Mole weight: 336.42. | |
| Ilaprazole Impurity 23 | Impurity of Ilaprazole. Synonyms: 2-(4-Chloro-3-methyl-pyridin-2-ylmethanesulfinyl)-5-pyrrol-1-yl-1H-benzoimidazole. Grades: > 95%. Molecular formula: C18H15ClN4OS. Mole weight: 370.86. | |
| Ilaprazole Impurity 23 | Ilaprazole Impurity 23. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2285346-40-7. Molecular Formula: C19H18N4OS. Mole Weight: 350.44. Catalog: APB2285346407. | |
| Ilaprazole Impurity 24 | Ilaprazole Impurity 24. Uses: For analytical and research use. Group: Impurity standards. CAS No. 172152-37-3. Molecular Formula: C19H18N4O3S. Mole Weight: 382.44. Catalog: APB172152373. | |
| Ilaprazole Impurity 24 | Impurity of Ilaprazole. Synonyms: 1-Methyl-8-pyrrol-1-yl-10-thioxo-10H-4a,5,9b-triaza-indeno[2,1-a]inden-2-one. Grades: > 95%. Molecular formula: C18H12N4OS. Mole weight: 332.39. | |
| Ilaprazole Impurity 25 | Impurity of Ilaprazole. Synonyms: 1-Methyl-8-pyrrol-1-yl-10-thioxo-10H-4a,5,9b-triaza-indeno[2,1-a]inden-2-one. Grades: > 95%. Molecular formula: C18H12N4OS. Mole weight: 332.39. | |
| Ilaprazole Impurity 27 | Ilaprazole Impurity 27. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1298015-58-3. Molecular Formula: C18H22N4OS. Mole Weight: 342.46. Catalog: APB1298015583. | |
| Ilaprazole Impurity 3 | Grades: > 95%. Molecular formula: C27H27N5O3S. Mole weight: 501.61. | |
| Ilaprazole Impurity 31 | Ilaprazole Impurity 31. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1360824-56-1. Molecular Formula: C27H27N5O2S. Mole Weight: 485.61. Catalog: APB1360824561. | |
| Ilaprazole Impurity 33 | Ilaprazole Impurity 33. Uses: For analytical and research use. Group: Impurity standards. CAS No. 172152-43-1. Molecular Formula: C20H20N4O2S. Mole Weight: 380.47. Catalog: APB172152431. | |
| Ilaprazole Impurity 4 | Grades: > 95%. Molecular formula: C19H17N4O3SNa. Mole weight: 404.43. | |
| Ilaprazole Impurity 40 | Ilaprazole Impurity 40. Uses: For analytical and research use. Group: Impurity standards. CAS No. 22876-21-7. Molecular Formula: C7H4N2O3S. Mole Weight: 196.18. Catalog: APB22876217. | |
| Ilaprazole Impurity 41 | Ilaprazole Impurity 41. Uses: For analytical and research use. Group: Impurity standards. CAS No. 4694-92-2. Molecular Formula: C7H6N2OS. Mole Weight: 166.62. Catalog: APB4694922. | |
| Ilaprazole Impurity 43 | Ilaprazole Impurity 43. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1298015-56-1. Molecular Formula: C19H18N4O2S. Mole Weight: 366.44. Catalog: APB1298015561. | |
| Ilaprazole Impurity 44 (Rabeprazole Impurity 21) | Ilaprazole Impurity 44 (Rabeprazole Impurity 21). Uses: For analytical and research use. Group: Impurity standards. CAS No. 86604-74-2. Molecular Formula: C8H11Cl2NO. Mole Weight: 208.08. Catalog: APB86604742. | |
| Ilaprazole Impurity 49 | Ilaprazole Impurity 49. Uses: For analytical and research use. Group: Impurity standards. CAS No. 910664-00-5. Molecular Formula: C15H16N4OS. Mole Weight: 300.38. Catalog: APB910664005. | |
| Ilaprazole Impurity 5 | Grades: > 95%. Molecular formula: C19H17N4O3SNa. Mole weight: 404.43. | |
| Ilaprazole Impurity 54 | Ilaprazole Impurity 54. Uses: For analytical and research use. Group: Impurity standards. CAS No. 2285346-44-1. Molecular Formula: C19H18N4O3S. Mole Weight: 382.44. Catalog: APB2285346441. | |
| Ilaprazole Impurity 55 | Ilaprazole Impurity 55. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1508282-87-8. Molecular Formula: C18H14N4O3. Mole Weight: 334.34. Catalog: APB1508282878. | |
| Ilaprazole Impurity 6 | Grades: > 95%. Molecular formula: C19H16ClN4O2SNa. Mole weight: 422.87. | |
| Ilaprazole Impurity 7 | Grades: > 95%. Molecular formula: C27H27N5O2S. Mole weight: 485.61. | |
| Ilaprazole Impurity 7 | Ilaprazole Impurity 7. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1360824-57-2. Molecular Formula: C19H17ClN4O2S. Mole Weight: 400.88. Catalog: APB1360824572. | |
| Ilaprazole Impurity 72 | Ilaprazole Impurity 72. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C16H20N2O4. Mole Weight: 304.35. Catalog: APB08162. | |
| Ilaprazole Impurity 73 | Ilaprazole Impurity 73. Uses: For analytical and research use. Group: Impurity standards. CAS No. 1508282-92-5. Molecular Formula: C19H18N4O3S. Mole Weight: 382.44. Catalog: APB1508282925. | |
| Ilaprazole Impurity 74 | Ilaprazole Impurity 74. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H8N6O4S2. Mole Weight: 388.38. Catalog: APB08114. | |
| Ilaprazole Impurity 75 | Ilaprazole Impurity 75. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C14H12N6S2. Mole Weight: 328.41. Catalog: APB08115. | |
| Ilaprazole Impurity 76 | Ilaprazole Impurity 76. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C19H19ClN4O. Mole Weight: 354.84. Catalog: APB08163. | |
| Ilaprazole Impurity 77 | Ilaprazole Impurity 77. Uses: For analytical and research use. Group: Impurity standards. Molecular Formula: C38H36Cl2N8O2S2. Mole Weight: 771.78. Catalog: APB08164. | |
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