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| Product | Description | |
|---|---|---|
| LY-2456302 | LY-2456302, also called as CERC-501, is a potent, highly selective and centrally-penetrant kappa opioid receptor antagonist (Ki = 0.807 nM) with favorable pharmacokinetic and pharmacodynamic properties to evaluate the role of KOR in preclinical models of alcoholism. Synonyms: 4-[4-[[(2S)-2-(3,5-dimethylphenyl)pyrrolidin-1-yl]methyl]phenoxy]-3-fluorobenzamide; 3-fluoro4-(4-((2-(3,5-dimethylphenyl)pyrrolidin-1-yl)methyl)phenoxy)benzamide; LY2456302; CERC-501; LY 2456302; CERC 501; LY-2456302; CERC501. CAS No. 1174130-61-0. Molecular formula: C26H27FN2O2. Mole weight: 418.5. |  |
| LY2457546 | LY2457546 is a potent and orally bioavailable inhibitor of multiple receptor tyrosine kinases involved in angiogenic and tumorigenic signalling. Synonyms: LY 2457546; LY-2457546. CAS No. 908265-94-1. Molecular formula: C28H20F4N4O. Mole weight: 504.48. | |
| LY 245769 | LY 245769 is a leukotriene E4 (LTE4) inhibitor, and it can inhibit the oxidative degradation of LTE4 and N-acetyl-LTE4 in animal model. LY 245769, as one of the omega-trifluoro analogs of leukotrienes, will provide a new tool for interfering with the inactivation of leukotrienes in the omega-oxidation pathway. Synonyms: LY 245769; LY-245769; LY245769; R-(R*,S*-(E,Z)))-3-(1H-tetrazol-5-yl)-alpha-(14,14,14-trifluoro-1-((2-(1H-tetrazol-5-yl)ethyl)thio)-2,4-tetradecadienyl)-3-(1H-tetrazol-5-yl)-alpha-(14,14,14-trifluoro-1-((2-(1H-tetrazol-5-yl)ethyl)thio)-2,4-tetradecadienyl)-. Grades: 98%. CAS No. 127345-02-2. Molecular formula: C25H33F3N8OS. Mole weight: 550.65. | |
| LY 249933 | LY 249933 is a bio-active molecular under the development of Eli Lilly. It has positive inotropic activity as a cardioselective 1,4-dihydropyridine compound. Uses: Positive inotropic activity. Synonyms: LY 249933; LY249933; LY-249933. 1-phenylethyl 2,6-dimethyl-5-nitro-4-thieno[3,2-c]pyridin-3-yl-1,4-dihydropyridine-3-carboxylate. Grades: 98%. CAS No. 123250-77-1. Molecular formula: C23H21N3O4S. Mole weight: 435.50. | |
| LY-2510924 | LY-2510924 is an inhibitor of CXC chemokine receptor 4 (CXCR4). It has potential antineoplastic activity. It binds to the chemokine receptor CXCR4, thereby preventing CXCR4 binding to its ligand, stromal derived factor-1 (SDF-1), and subsequent receptor activation upon subcutaneous administration, which may result in decreased tumor cell proliferation and migration. It plays an important role in chemotaxis and angiogenesis and is upregulated in several tumor cell types. Uses: Ly-2510924 has potential antineoplastic activity. it plays an important role in chemotaxis and angiogenesis. Synonyms: LY2510924; LY 2510924; Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2; Cyclo[Phe-Tyr-Lys(iPr)-D-Arg-2-Nal-Gly-D-Glu]-Lys(iPr)-NH2; L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7?1)-lactam; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2. Grades: 98%. CAS No. 1088715-84-7. Molecular formula: C62H88N14O10. Mole weight: 1189.47. | |
| LY2510924 acetate | Ly2510924 acetate is a potent and selective CXCR4 antagonist that prevents the binding of SDF-1 to CXCR4 with an IC50 of 0.079 nM. It has potential antineoplastic activity. Synonyms: L-Lysinamide, L-phenylalanyl-L-tyrosyl-N6-(1-methylethyl)-L-lysyl-D-arginyl-3-(2-naphthalenyl)-L-alanylglycyl-D-α-glutamyl-N6-(1-methylethyl)-, (7?1)-lactam, acetate (1:1); LY 2510924 acetate; LY-2510924 acetate; N(1)Phe-Tyr-Lys(iPr)-D-Arg-2Nal-Gly-D-Glu(1)-Lys(iPr)-NH2 acetate. Grades: ≥95%. Molecular formula: C62H88N14O10.C2H4O2. Mole weight: 1249.53. | |
| LY 255262 | This bio-active molecular is a antibacterial agent with a pyrazolidinone structure. Uses: Antibacterial. Synonyms: LY 255262; LY255262; LY-255262. 2-[[(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-methoxyiminoacetyl]amino]-6-cyano-3-oxo-2,7-dihydro-1H-pyrazolo[1,2-a]pyrazole-5-carboxylic acid. Grades: 98%. CAS No. 124986-45-4. Molecular formula: C14H13N7O5S. Mole weight: 391.36. | |
| LY255283 | This active molecular is a competitive leukotriene B4 receptor antagonist and IC50 value is about 100 nM. LY 255283 is selective for the BLT2 receptor, since IC50 values at the BLT1 receptor are >10 μM. LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10 μM. It also inhibits the binding of radiolabeled LTB4 to eosinophil membranes and IC50 value is 260 nM. LY255283 reduces airway obstruction in animal models of asthma. However, clinical trials for asthma had been discontinued. Uses: Asthma. Synonyms: LY 255283; LY255283; LY-255283; (1-(5-Ethyl-2-hydroxy-4-(6-methyl-6-(1H-tetrazol-5-yl)heptyloxy)phenyl)ethanone). Grades: 98%. CAS No. 117690-79-6. Molecular formula: C19H28N4O3. Mole weight: 360.45. | |
| LY255283 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. |  |
| LY 255283 | LY255283, a competitive leukotriene B4 receptor antagonist, is used in leukotriene receptor research along with other selective leukotriene receptor agonists and antagonist to identify and differentiate the physiological and cell signaling effects of the leukotriene B4 receptor on processes such as paclitaxel resistance in MCF-7/DOX breast cancer cells, monocyte-derived dendritic cell chemotaxis, and 5-lipoxygenase activity and interleukin-8 production in human neutrophils. LY255283 may be used to help verify that an observed process or cell event is leukotriene B4 receptor-dependent.Antagonists of the chemotactic and inflammatory lipoxygenase product leukotriene B4 (LTB4) have been potential drug development targets for several years.1,2 The tetrazole LY255283 is a competitive antagonist of the BLT2 receptor. It displaces radiolabeled LTB4 from guinea pig lung membrane, with an IC50 of about 100nM.3 LY255283 exhibits IC50 values of ~950nM and >10uM at human recombinant BLT2 and BLT1 receptors, respectively.4 LY255283 inhibits eosinophil chemotaxis by 80% at a concentration of 10uM, and inhibits the binding of radiolabeled LTB4 to eosinophil membranes with an IC50 of 260nM.1. Group: Biochemicals. Alternative Names: 1-[5-ethyl-2-hydroxy-4-[[6-methyl-6-(1H-tetrazol-5-yl)heptyl]oxy]phenyl]-ethanone. Grades: Highly Purified. CAS No. 117690-79-6. Pack Sizes: 10mg, 25mg. Molecular Formula: C19H28N4O3, Molecular Weight: 360.5. US Biological Life Sciences. |  Worldwide |
| LY255582 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY-2562175 | LY2562175 is a potent and selective FXR agonist in vitro. It has robust lipid modulating properties, lowering LDL and triglycerides while raising HDL in preclinical species. It was developed by Eli Lilly and Company and in clinic phase 1 trials with no progress. Uses: Ly2562175 has robust lipid modulating properties, lowering ldl and triglycerides while raising hdl in preclinical species. Synonyms: LY2562175; LY 2562175; LY-2562175;6-(4-((5-Cyclopropyl-3-(2,6-dichlorophenyl)isoxazol-4-yl)methoxy)piperidin-1-yl)-1-methyl-1H-indole-3-carboxylic acid. Grades: >98%. CAS No. 1103500-20-4. Molecular formula: C28H27Cl2N3O4. Mole weight: 540.44. | |
| LY-256548 | LY-25648 is a leukotriene B4 antagonist. Synonyms: LY 25648; LY-25648; LY25648; Dihydro-3-methyl-5-(4-hydroxy-3,5-ditert-butylbenzylidene)thiazol-4(5H)-one;LY25648;5-(3,5-Bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene-N-methyl-4-thiazolidinone;(5Z)-5-[(3,5-ditert-butyl-4-hydroxyphenyl)methylidene]-3-methyl-1,3-thiazolidin-4-one. Grades: >98%. CAS No. 107889-31-6. Molecular formula: C19H27NO2S. Mole weight: 333.49. | |
| LY 257883 | LY 257883, also known as PPPA, is a competitive NMDA receptor antagonist which displays moderate selectivity for NR2A-containing receptors. Ki values are 0.13μM for NR2A, 0.47μM for NR2B, 1.10μM for NR2C and 3.86 μM for NR2D. Related experiments show that the increase in potency on raising of the extracellular pH results largely from an increase in the antagonist association rate constant but also from a small decrease in the dissociation rate constant. These results suggest that the fully ionized forms of the LY 257883 act as the active antagonist species at NMDA receptors. Synonyms: LY 257883; LY-257883; LY257883; 4-(3-phosphonopropyl)piperidine-2-carboxylic acid,PPPA. Grades: 98%. CAS No. 118183-22-5. Molecular formula: C9H18NO5P. Mole weight: 251.22. | |
| LY2584702 | LY2584702 is an orally available inhibitor of p70S6K signaling, with potential antineoplastic activity. Synonyms: LY-2584702; LY 2584702. CAS No. 1082949-67-4. Molecular formula: C21H19F4N7. Mole weight: 445.4256. | |
| LY-2584702 hydrochloride | The hydrochloride salt form of LY2584702 which is a selective ATP competitive inhibitor of p70 S6 kinase. LY2584702 is still under Phase I trial for evaluating its potential anti-tumor effect.IC50: 4 nM (LY2584702). Uses: The hydrochloride salt form of ly2584702 which is a selective atp competitive inhibitor of p70 s6 kinase. Synonyms: LY-2584702 (hydrochloride); LY 2584702 (hydrochloride); LY2584702 (hydrochloride); SCHEMBL312564; CS-3598; CS 3598; CS3598. Grades: 98%. CAS No. 1082948-81-9. Molecular formula: C21H20ClF4N7. Mole weight: 481.88. | |
| LY2584702 Tosylate | LY2584702 Tosylate is a selective, ATP-competitive p70S6K inhibitor with IC50 of 4 nM. Phase 1. Synonyms: 4-(4-(4-(4-fluoro-3-(trifluoromethyl)phenyl)-1-methyl-1H-imidazol-2-yl)piperidin-1-yl)-1H-pyrazolo[3,4-d]pyrimidine 4-methylbenzenesulfonate; LY2584702; LY 2584702; LY-2584702; LYS6K2. Grades: >98%. CAS No. 1082949-68-5. Molecular formula: C28H27F4N7O3S. Mole weight: 617.62. | |
| LY2603618 | LY2603618 is a potent and selective small molecule inhibitor of Chk1 protein kinase activity in vitro (IC50=7 nM) and the first selective Chk1 inhibitor to enter clinical cancer trials. Synonyms: LY-2603618; LY 2603618; Rabusertib. Grades: >98%. CAS No. 911222-45-2. Molecular formula: C18H22BrN5O3. Mole weight: 436.31. | |
| LY2606368 | LY2606368 is a potent and selective ATP competitive inhibitor(IC50=1.5 nM in SW1990 cell) of the Chk1 protein kinase. Synonyms: LY-2606368; LY 2606368. Grades: >98%. CAS No. 1234015-52-1. Molecular formula: C18H19N7O2. Mole weight: 365.397. | |
| LY2606368 dihydrochloride | The dihydrochloride salt form of LY2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. It is still under Phase II clinical trial against breast cancer and some other sorts of cancers. Uses: The dihydrochloride salt form of ly2606368 which also known as prexasertib, is an inhibitor of checkpoint kinase 1 and has potential effect in antineoplastic. Synonyms: UNII-9RFT476U2L; 9RFT476U2L; LY2606368 (dihydrochloride); 1234015-54-3; HY-18174A; CS-3507; CS 3507; CS3507; LY2606368; LY 2606368; LY-2606368. Grades: 98%. CAS No. 1234015-54-3. Molecular formula: C18H21Cl2N7O2. Mole weight: 438.31. | |
| LY2608204 | LY2608204 activates glucokinase (GK) with EC50 of 42 nM at 10 mM glucose with a concentration dependent manner at lower glucose concentrations. Uses: Enzyme activators. Synonyms: LY-2608204; LY 2608204; LY2608204. Grades: >98%. CAS No. 1234703-40-2. Molecular formula: C28H37N3O3S3. Mole weight: 559.81. | |
| LY266097 | ?98% (HPLC), powder. Group: Fluorescence/luminescence spectroscopy. | |
| LY 266097 hydrochloride | LY 266097 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 172895-39-5. Pack Sizes: 10mg, 50mg. US Biological Life Sciences. | Worldwide |
| LY 266097 hydrochloride | LY 266097 hydrochloride is a 5-HT2B receptor antagonist. It can attenuate amphetamine-induced locomotion in the rat. Synonyms: LY 266097 hydrochloride; LY266097 hydrochloride; LY-266097 hydrochloride; 1-[(2-Chloro-3,4-dimethoxyphenyl)methyl]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 172895-39-5. Molecular formula: C21H23ClN2O2.HCl. Mole weight: 407.33. | |
| LY 269415 | LY 269415 is a 5-Lipoxygenase inhibitor originated by Eli Lilly. It is a potent antioxidant with antiinflammatory properties in vitro. But no development was reported for Rheumatic disorders in USA. Uses: Rheumatic disorders. Synonyms: LY 269415; LY269415; LY-269415. 5-((3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl)methylene)-3-(methylamino)-4-Thiazolidinone. Grades: 98%. CAS No. 132392-65-5. Molecular formula: C19H28N2O2S. Mole weight: 348.51. | |
| LY 272015 hydrochloride | LY 272015 hydrochloride is a selective 5-HT2B receptor antagonist. Synonyms: LY 272015 hydrochloride; LY272015 hydrochloride; LY-272015 hydrochloride; 1-[(3,4-Dimethoxyphenyl)methy]-2,3,4,9-tetrahydro-6-methyl-1H-pyrido[3,4-b]indole hydrochloride. Grades: ≥99% by HPLC. CAS No. 172895-15-7. Molecular formula: C21H24N2O2.HCl. Mole weight: 372.89. | |
| LY-272015 hydrochloride | LY-272015 hydrochloride is an orally active, specific 5-HT 2B receptor antagonist. LY-272015 hydrochloride completely inhibits the phosphorylation of ERK2 induced by 5-HT or BW723C86. LY-272015 hydrochloride is antihypertensive in Deoxycorticosterone Acetate (DOCA)-salt-hypertensive rats [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 172895-15-7. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-100851A. |  |
| LY 274614 | LY 274614 is a competitive Glutamate receptor antagonist originated by Eli Lilly. It is a promising therapeutic agent for conditions where glutamate plays a role in the pathology of neuronal degeneration. But no development was reported for the treatment of Alzheimer's disease, Epilepsy, Huntington's disease, Neuroprotection and Parkinson's disease yet. Uses: Alzheimer's disease; epilepsy; huntington's disease; neuroprotection; parkinson's disease. Synonyms: LY 274614; LY 274614; LY 274614. (3alpha,4aalpha,6beta,8aalpha)-decahydro-6-(phosphonomethyl)- 3-Isoquinolinecarboxylic acid. Grades: 98%. CAS No. 136109-04-1. Molecular formula: C11H20NO5P. Mole weight: 277.26. | |
| LY2784544 | LY2784544 is a potent and selective JAK2 inhibitor (IC50 = 3 nM), and exhibits less potency against JAK3 (IC50 =48 nM). LY2784544 effectively inhibits JAK2V617F-driven signaling and cell proliferation in Ba/F3 cells (IC50 = 20 and 55 nM, respectively). It reduces JAK2V617F tumor cell burden with no effect on erythroid progenitor cells. Synonyms: Gandotinib; LY-2784544; 3-[(4-chloro-2-fluorophenyl)methyl]-2-methyl-N-(5-methyl-1H-pyrazol-3-yl)-8-(morpholin-4-ylmethyl)imidazo[1,2-b]pyridazin-6-amine. Grades: >98%. CAS No. 1229236-86-5. Molecular formula: C23H25ClFN7O. Mole weight: 469.949. | |
| LY 278584 | LY 278584 is a 5-HT3-receptor antagonist and no detailed information has been published yet. Synonyms: LY 278584; LY-278584; LY278584. 1-methyl-N-[(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl]indazole-3-carboxamide. Grades: 98%. CAS No. 119193-37-2. Molecular formula: C17H22N4O. Mole weight: 298.39. | |
| LY2795050 | LY2795050 is a short-acting selective κ(kappa)-opioid receptor (KOR) antagonist. LY2795050 has high affinity for the KOR with K i value of 0.72 nM. LY2795050 can be used for the research of central nervous system dysfunction [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1346133-08-1. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg. Product ID: HY-15708. | |
| LY2795050 | LY2795050, a κ-opioid Receptor antagonist, has been found to be effective in imaging KOR behaving as a PET tracer. IC50: 0.72 nM and 25.8 nM for κ-opioid Receptor and κ-opioid. Uses: Ly2795050 is a κ-opioid receptor antagonist that has been found to be effective in imaging kor behaving as a pet tracer. Synonyms: LY2795050; LY 2795050; LY-2795050; (S)-LY2795050; UNII-71PAL357HO; CHEMBL1921842; 71PAL357HO; BDBM50358166. Grades: 98%. CAS No. 1346133-08-1. Molecular formula: C23H22ClN3O2. Mole weight: 407.89. | |
| LY2801653 | LY2801653 is an orally available, small molecule inhibitor of the proto-oncogene c-Met with potential antineoplastic activity. Synonyms: LY-2801653; LY 2801653. Grades: >98%. CAS No. 1206799-15-6. Molecular formula: C30H22F2N6O3. Mole weight: 552.542. | |
| LY2801653 dihydrochloride | LY2801653 is a type-II ATP competitive, slow-off inhibitor of MET tyrosine kinase with a dissociation constant (K(I)) of 2 nM, a pharmacodynamic residence time (K(off)) of 0.00132 min(-1) and t(1/2) of 525 min [1]. LY2801653 was found to have potent activity against several other receptor tyrosine oncokinases including MST1R, FLT3, AXL, MERTK, TEK, ROS1, DDR1/2 and against the serine/threonine kinases MKNK1/2. LY2801653 demonstrated in vitro effects on MET pathway-dependent cell scattering and cell proliferation; in vivo anti-tumor effects in MET amplified (MKN45), MET autocrine (U-87MG, and KP4) and MET over-expressed (H441) xenograft models; and in vivo vessel normalization effects. Synonyms: LY-2801653 dihydrochloride; LY 2801653 dihydrochloride. Grades: >98%. CAS No. 1206801-37-7. Molecular formula: C30H24Cl2F2N6O3. Mole weight: 625.45. | |
| LY-280748 | LY-280748, a tetrazol derivative, could probably be significant in some studies for its biological activities. Synonyms: LY 280748; LY280748; LY-280748. [1,1'-Biphenyl]-2-ol,5-ethyl-4-[[6-methyl-6-(2H-tetrazol-5-yl)heptyl]oxy]-, sodium salt (1:1); 2-Phenyl-4-ethyl-5-(6-(2H-tetrazol-5-yl)-6-methylheptyloxy)phenol sodium salt; LY-280748; ACMC-20d2d5. Grades: 98%. CAS No. 153226-99-4. Molecular formula: C23H29N4NaO2. Mole weight: 416.50. | |
| LY2811376 | LY2811376, under the IUPAC name (4S)-4-(2,4-difluoro-5-pyrimidin-5-ylphenyl)-4-methyl-5,6-dihydro-1,3-thiazin-2-amine, is the first orally available non-peptidi Beta secretase (BACE) inhibitor (IC50 = 239-249 nM) with the potent effect of treating Alzheimer's Disease. In vivo, LY2811376 inhibits BACE1 activity by concomitantly reducing C99 and sAPPb, the two primary APP cleavage products generated by BACE1. In vitro, LY2811376 demonstrates concentration-dependent inhibition of hBACE1 with an IC50 of 239 and 249 nM. Synonyms: 4H-1,3-Thiazin-2-amine, 4-[2,4-difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-, (4S)-; (4S)-4-[2,4-Difluoro-5-(5-pyrimidinyl)phenyl]-5,6-dihydro-4-methyl-4H-1,3-thiazin-2-amine; LY 2811376; LY-2811376; (S)-4-(2,4-Difluoro-5-(pyrimidin-5-yl)phenyl)-4-methyl-5,6-dihydro-4H-1,3-thiazin-2-amine. Grades: ≥95%. CAS No. 1194044-20-6. Molecular formula: C15H14F2N4S. Mole weight: 320.36. | |
| LY-281217 | LY-281217 is an organic opioid agonist. It can produce analgesic effects in mice. Uses: Ly-281217 can produce analgesic effects. Synonyms: LY 281217; LY281217; LY-281217. N,N-Di(2-propenyl)-L-Tyr-2-methyl-Ala-2-methyl-Ala-L-Phe-OH;N-[N-[N-(N,N-Di-2-propenyl-L-tyrosyl)-2-methylalanyl]-2-methylalanyl]-L-phenylalanine;(2S)-2-[[2-[[2-[[(2S)-2-[bis(prop-2-enyl)amino]-3-(4-hydroxyphenyl)propanoyl]amino]-2-methylpropanoyl]amino]-2-methylpropanoyl]amino]-3-phenylpropanoic acid;LY281217;L-Phenylalanine, N-(N-(N-(N,N-di-2-propenyl-L-tyrosyl)-2-methylalanyl)-2-methylalanyl)-. Grades: >99 %. CAS No. 105027-75-6. Molecular formula: C32H42N4O6. Mole weight: 578.71. | |
| LY2828360 | LY2828360 is a selective cannabinoid (CB) receptor 2 agonist (Ki = 40.3 nM). LY2828360 (3 mg/kg per day i.p. × 12 days) suppressed chemotherapy-induced neuropathic pain produced by paclitaxel without producing tolerance in wild-type mice. Synonyms: LY-2828360; LY 2828360; 8-(2-Chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)-9-(tetrahydro-2H-pyran-4-yl)-9H-purine. Grades: ≥98%. CAS No. 1231220-79-3. Molecular formula: C22H27ClN6O. Mole weight: 426.94. | |
| LY285434 | An antagonist of angiotensin II receptor. Synonyms: LY285434; LY 285434; LY-285434; 2-[5-[2-(2H-tetrazol-5-yl)phenyl]indol-1-yl]octanoic acid. CAS No. 159748-08-0. Molecular formula: C23H25N5O2. Mole weight: 403.48. | |
| LY2857785 | LY2857785 is a potent and selective CDK9 inhibitor; significantly reduces RNAP II CTD phosphorylation and dramatically decreases MCL1 protein levels to result in apoptosis in a variety of leukemia and solid tumor cell lines. Synonyms: LY2857785; LY-2857785; LY 2857785. Grades: >98%. CAS No. 1619903-54-6. Molecular formula: C26H36N6O. Mole weight: 448.6. | |
| LY2874455 | LY2874455 is a pan-FGFR inhibitor with IC 50 s of 2.8, 2.6, 6.4, 6 nM for FGFR1 , FGFR2 , FGFR3 , FGFR4 , respectively. Uses: Scientific research. Group: Signaling pathways. CAS No. 1254473-64-7. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-13304. | |
| LY2874455 | LY2874455 exhibits a potent activity against FGF/FGFR-mediated signaling in several cancer cell lines and shows an excellent broad spectrum of antitumor activity in several tumor xenograft models representing the major FGF/FGFR relevant tumor histologies including lung, gastric, and bladder cancers and multiple myeloma, and with a well-defined pharmacokinetic/pharmacodynamic relationship. Synonyms: LY2874455; LY 2874455; LY-2874455. Grades: >98%. CAS No. 1254473-64-7. Molecular formula: C21H19Cl2N5O2. Mole weight: 444.316. | |
| LY2880070 | LY2880070 is an orally active CHK1 inhibitor, IC 50 ? 1 nM. LY2880070 can be used as an anticancer agent for combination with DNA damaging agents [1] [2]. Uses: Scientific research. Group: Signaling pathways. CAS No. 1375637-35-6. Pack Sizes: 5 mg; 10 mg; 25 mg; 50 mg. Product ID: HY-148962. | |
| LY 288513 | LY 288513 is a CCK2 receptor antagonist with IC50 value of 16nM. It shows anxiolytic and antipsychotic properties in vivo. Synonyms: LY 288513; LY288513; LY-288513; (4S,5R)-N-(4-Bromophenyl)-3-oxo-4,5-diphenyl-1-pyrazolidinecarboxamide. Grades: ≥98% by HPLC. CAS No. 147523-65-7. Molecular formula: C22H18BrN3O2. Mole weight: 436.3. | |
| LY2886721 | LY2886721, under the IUPAC name N-(3-(2-amino-4a,5,7,7a-tetrahydro-4H-furo(3,4-d)(1,3)thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide, is the first oral small molecule inhibitting Beta secretase (BACE) to reach Phase 2 clinical research. It was developed by Eli Lilly & Co. with the potention to treat Alzheimer's Disease. Synonyms: N-(3-((4aS,7aS)-2-amino-4a,5,7,7a-tetrahydro-4H-furo[3,4-d][1,3]thiazin-7a-yl)-4-fluorophenyl)-5-fluoropicolinamide; LY2886721; LY-2886721; LY 2886721. CAS No. 1262036-50-9. Molecular formula: C18H16F2N4O2S. Mole weight: 390.41. | |
| LY 2886721 hydrochloride | LY 2886721 hydrochloride is the first oral inhibitor of human β-secretase (BACE-1) with the potential to treat Alzheimer's Disease. Uses: Potential treatment of alzheimer's disease. Synonyms: LY 2886721 hydrochloride; LY2886721 hydrochloride; LY-2886721 hydrochloride; N-[3-[(4aS,7aS)-2-amino-4,4a,5,7-tetrahydrofuro[3,4-d][1,3]thiazin-7a-yl]-4-fluorophenyl]-5-fluoropyridine-2-carboxamide hydrochloride. Grades: 99%. CAS No. 1262036-49-6. Molecular formula: C18H16F2N4O2S.HCl. Mole weight: 426.87. | |
| LY 290324 | LY 290324, a quinoline derivative, has been found to be a Leukotriene D4 receptor antagonist that could be probably effective as antiallergic and antiasthmatic agent. It has no development-reported since 1998. Synonyms: LY290324; LY-290324; 5-(2-(1-(3-(2-(7-Chloroquinolin-2-yl)ethenyl)benzyl)indol-7-yl)ethyl)-1H-tetrazole. Grades: 98%. CAS No. 146554-87-2. Molecular formula: C29H24Cl2N6. Mole weight: 527.45. | |
| LY2922470 | LY2922470 Inhibitor. Uses: Scientific use. Product Category: T15810. CAS No. 1423018-12-5. |  |
| LY 292728 | LY 292728, an oxoxanthene derivative, has been found to be a leukotriene B4 receptor antagonist that has once been studied as an antiasthmatic agent. Synonyms: LY 292728; LY292728; LY-292728; CHEMBL292782; 9h-xanthene-4-propanoic acid, 7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propoxy]-9-oxo-; 9H-Xanthene-4-propanoicacid,7-carboxy-3-[3-[(5-ethyl-4'-fluoro-2-hydroxy[1,1'-biphenyl]-4-yl)oxy]propox. Grades: 98%. CAS No. 153034-77-6. Molecular formula: C34H29FO9. Mole weight: 600.60. | |
| LY 293284 | LY-293284 is a Serotonin 1A receptor agonist developed by Eli Lilly. It is a selective 5-HT1A receptor full agonist. LY-293284 is far more selective for 5-HT1A with over 1000x selectivity over other serotonin receptor subtypes and other targets. No development was reported for the treatment of Anxiety disorders and Major depressive disorder. Uses: Anxiety disorders; major depressive disorder. Synonyms: LY 293284; LY293284; LY-293284. (R)-1-(4-(dipropylamino)-1,3,4,5-tetrahydrobenz(cd)indol-6-yl)-Ethanone. Grades: 98%. CAS No. 141318-62-9. Molecular formula: C19H26N2O. Mole weight: 298.43. | |
| LY-293559 | LY 215490, a decahydroisoquinoline derivative, has been found to be an AMPA receptor antagonist that could be a neuroprotective agent in the study of focal ischaemia. Synonyms: LY-293559; LY 215490; LY-215490; CHEMBL70937; SCHEMBL3678843; ZINC5760; (3R,4aS,6S,8aS)-6-[2-(2H-tetrazol-5-yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinoline-3-carboxylic acid. Grades: 98%. CAS No. 150010-68-7. Molecular formula: C13H21N5O2. Mole weight: 279.34. | |
| LY 293606 | GYKI-53405 is a noncompetitive α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPA receptor) antagonist. It can bind to Xenopus brain membranes with KD and Bmax values of 4.5 mM and 35 pmol mg-1 protein respectively. Synonyms: GYKI-53405; GYKI 53405; GYKI53405; LY 293606; LY-293606; LY293606; 1-(4-Aminophenyl)-3-acetyl-4-methyl-3,4-dihydro-7,8-methylenedioxy-5H-2,3-benzodiazepine. Grades: 98%. CAS No. 143691-37-6. Molecular formula: C19H19N3O3. Mole weight: 337.38. | |
| LY294002 | LY294002 Inhibitor. Uses: Scientific use. Product Category: T2008. CAS No. 154447-36-6. | |
| LY294002 | Potent, cell permeable, highly specific PI(3)K (phosphoinositide 3-kinase) inhibitor. Acts on the ATP-binding site of the enzyme. Antagonizes P-glycoprotein-mediated multidrug resistance. Blocks Akt phosphorylation. Pim-1 kinase inhibitor. Group: Biochemicals. Grades: Highly Purified. CAS No. 154447-36-6. Pack Sizes: 1mg, 5mg, 25mg. Molecular Formula: C19H17NO3. US Biological Life Sciences. | Worldwide |
| LY294002 | LY294002 is a potent inhibitor of phosphoinositide PI3Kα/δ/β with IC50 of 0.5 μM/0.57 μM/0.97 μM, respectively. Synonyms: LY294002; LY-294002; LY 294002; 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; 2-morpholino-8-phenyl-4H-chromen-4-one. Grades: >98%. CAS No. 154447-36-6. Molecular formula: C19H17NO3. Mole weight: 307.349. | |
| LY294002 | LY294002 is a broad-spectrum inhibitor of PI3K with IC 50 s of 0.5, 0.57, and 0.97 μM for PI3Kα , PI3Kδ and PI3Kβ , respectively [1]. LY294002 also inhibits CK2 with an IC 50 of 98 nM [2]. LY294002 is a competitive DNA-PK inhibitor that binds reversibly to the kinase domain of DNA-PK with an IC 50 of 1.4 μM. LY294002 is an apoptosis activator [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 154447-36-6. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 50 mg; 100 mg; 200 mg; 500 mg. Product ID: HY-10108. | |
| LY 294002 | Cas No. 154447-36-6. | |
| LY 294002, 4?-NH? - CAS 942289-87-4 | A cell-permeable LY 294002 4'-amino derivative with enhanced potency against p110?/?/?/?. Group: Fluorescence/luminescence spectroscopy. | |
| LY 294002 - CAS 154447-36-6 | LY294002, CAS 154447-36-6, is a cell-permeable, potent, reversible, and specific inhibitor of PI 3-kinase ((IC?? = 1.4 μM). Acts on the ATP-binding site. Group: Fluorescence/luminescence spectroscopy. | |
| LY 294002 hydrochloride | LY 294002 hydrochloride. Group: Biochemicals. Grades: Purified. CAS No. 934389-88-5. Pack Sizes: 5mg, 25mg. US Biological Life Sciences. | Worldwide |
| LY 294002 hydrochloride | LY 294002 hydrochloride is a PI 3-kinase inhibitor with IC50 values of 0.31μM for PI 3-Kβ, 0.73μM for PI 3-Kα, 1.06μM for PI 3-Kδ and 6.60μM for PI 3-K&gamma. It can inhibit proliferation and induce apoptosis in human colon cancer cells. Synonyms: 2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one hydrochloride. Grades: ≥99% by HPLC. CAS No. 934389-88-5. Molecular formula: C19H17NO3.HCl. Mole weight: 343.81. | |
| LY-294,002 hydrochloride | solid, ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY294002 hydrochloride | LY294002 hydrochloride is a potent and broad-spectrum PI3K inhibitor, with IC 50 values of 0.5, 0.57, and 0.97 μM for P110α , P110δ and P110β , respectively. LY294002 hydrochloride also inhibits CK2 with an IC 50 of 98 nM. LY294002 hydrochloride can be used for pancreatic cancer research [1] [2] [3]. Uses: Scientific research. Group: Signaling pathways. CAS No. 934389-88-5. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-10108A. | |
| LY2955303 | ?98% (HPLC). Group: Fluorescence/luminescence spectroscopy. | |
| LY2955303 | LY 2955303, is a potent and selective retinoic acid receptor gamma (RARγ) antagonist with a Ki of 1.09 nM. Uses: Osteoarthritis pain. Synonyms: 4-[5-[3,5-Bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]benzoic Acid; LY-2955303; LY2955303; 4-(5-[3,5-Bis(2-methyl-2-propanyl)phenyl]-1-{4-[(4-methyl-1-piperazinyl)carbonyl]phenyl}-1H-pyrazol-3-yl)benzoic acid; Benzoic acid, 4-[5-[3,5-bis(1,1-dimethylethyl)phenyl]-1-[4-[(4-methyl-1-piperazinyl)carbonyl]phenyl]-1H-pyrazol-3-yl]-. Grades: 98%. CAS No. 1433497-19-8. Molecular formula: C36H42N4O3. Mole weight: 578.74. | |
| LY 2955303 hydrochloride | LY 2955303 hydrochloride is a potent and selective retinoic acid receptor gamma (RARγ) antagonist (Ki values >1700 nM, >2980 nM, and 1.1 nM for RARα, RARβ, and RARγ, respectively) commonly used for the treatment of osteoarthritis joint pain. Uses: The treatment of osteoarthritis joint pain. Synonyms: LY 2955303 hydrochloride; LY2955303 hydrochloride; LY-2955303 hydrochloride; 4-(5-(3,5-di-tert-butylphenyl)-1-(4-(4-methylpiperazine-1-carbonyl)phenyl)-1H-pyrazol-3-yl)benzoic acid hydrochloride. Grades: 98%. Molecular formula: C36H42N4O3.HCl. Mole weight: 615.2. | |
| LY2979165 | LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants. Synonyms: LY-2979165; LY 2979165. Grades: 0.98. CAS No. 1311385-32-6. Molecular formula: C13H22N6O6S. Mole weight: 390.415. | |
| LY3009120 | LY03009120 is a potent pan-Raf inhibitor with IC50 of 44 nM, 31-47 nM, and 42 nM for A-raf, B-Raf, and C-Raf in A375 cells, respectively. Phase 1. Synonyms: LY3009120; LY-3009120; LY 3009120; DP4978; DP 4978; DP-4978. Grades: 98%. CAS No. 1454682-72-4. Molecular formula: C23H29FN6O. Mole weight: 424.51. | |
| LY3009120 | LY3009120 (DP-4978) is a pan RAF inhibitor which inhibits BRAF V600E , BRAF WT and CRAF WT with IC 50 s of 5.8, 9.1 and 15 nM, respectively. Uses: Scientific research. Group: Signaling pathways. Alternative Names: DP-4978. CAS No. 1454682-72-4. Pack Sizes: 10 mM * 1 mL; 5 mg; 10 mg; 25 mg; 50 mg; 100 mg. Product ID: HY-12558. | |
| LY 302148 | LY 302148 is a 5-HT1F receptor agonist with potential for migraine therapeutics. Synonyms: 5-fluoro-3-[1-[2-(1-methylpyrazol-4-yl)ethyl]piperidin-4-yl]-1H-indole; 5-fluoro-3-(1-(2-(1-methyl-1H-pyrazol-4-yl)ethyl)-4-piperidinyl)-1H-indole; LY 302148; LY 302148, monohydrochloride; LY-302148. Grades: >98%. CAS No. 182564-47-2. Molecular formula: C19H23FN4. Mole weight: 326.42. | |
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